Motif 676 (n=122)

Position-wise Probabilities

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uniprot genes site source protein function
O00418 EEF2K S491 psp Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.
O15126 SCAMP1 S112 ochoa Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
O15372 EIF3H S236 ochoa Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
O43491 EPB41L2 S392 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O43524 FOXO3 S321 psp Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O43822 CFAP410 S165 ochoa Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}.
O60763 USO1 S851 ochoa General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.
O60934 NBN S278 psp Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}.
O75150 RNF40 S853 psp E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
O75665 OFD1 S899 ochoa|psp Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O75943 RAD17 S646 psp Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}.
O94818 NOL4 S239 ochoa Nucleolar protein 4 (Nucleolar-localized protein) None
O95235 KIF20A S635 ochoa Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95260 ATE1 S169 ochoa Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250|UniProtKB:Q9Z2A5, ECO:0000269|PubMed:34893540}.
O95490 ADGRL2 S1353 ochoa Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}.
O95613 PCNT S1814 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
P06753 TPM3 S62 ochoa Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.
P07951 TPM2 S61 ochoa Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.
P09493 TPM1 S61 psp Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
P10645 CHGA S126 ochoa Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.
P12882 MYH1 S1144 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S1140 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S1142 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S1143 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P23327 HRC S221 ochoa Sarcoplasmic reticulum histidine-rich calcium-binding protein May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
P26232 CTNNA2 S654 ochoa Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.
P27105 STOM S231 ochoa Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
P28290 ITPRID2 S33 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P29144 TPP2 S1039 ochoa Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}.
P33993 MCM7 S314 ochoa DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
P35241 RDX S532 ochoa Radixin Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
P35269 GTF2F1 S345 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P35580 MYH10 S1145 ochoa Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}.
P35749 MYH11 S1314 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P35749 MYH11 S1770 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P38398 BRCA1 S1217 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P43121 MCAM S614 ochoa Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.
P46100 ATRX S1418 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46939 UTRN S784 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P55010 EIF5 S229 ochoa Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
P55081 MFAP1 S94 ochoa Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}.
P57768 SNX16 S298 ochoa Sorting nexin-16 May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}.
P61278 SST S74 ochoa Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}.
P61981 YWHAG S155 ochoa 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}.
P78347 GTF2I S103 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
Q02224 CENPE S611 ochoa Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}.
Q03188 CENPC S615 ochoa Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.
Q06265 EXOSC9 S306 ochoa Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}.
Q12929 EPS8 S790 psp Epidermal growth factor receptor kinase substrate 8 Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.
Q13136 PPFIA1 S448 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13796 SHROOM2 S1337 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14690 PDCD11 S1498 ochoa Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}.
Q14789 GOLGB1 S869 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q1MSJ5 CSPP1 S77 ochoa Centrosome and spindle pole-associated protein 1 May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}.
Q5T9A4 ATAD3B S120 ochoa ATPase family AAA domain-containing protein 3B (AAA-TOB3) May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. {ECO:0000269|PubMed:22664726}.
Q5VUB5 FAM171A1 S494 ochoa Protein FAM171A1 (Astroprincin) (APCN) Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.
Q5VZ18 SHE S341 ochoa SH2 domain-containing adapter protein E None
Q5VZ89 DENND4C S1802 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q66K14 TBC1D9B S547 ochoa TBC1 domain family member 9B May act as a GTPase-activating protein for Rab family protein(s).
Q6WKZ4 RAB11FIP1 S935 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q7Z406 MYH14 S1324 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q86SQ0 PHLDB2 S896 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86W56 PARG S316 ochoa Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}.
Q8N4C6 NIN S1193 ochoa Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.
Q8N4N8 KIF2B S616 psp Kinesin-like protein KIF2B Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}.
Q8NDI1 EHBP1 S307 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q8NEJ9 NGDN S204 ochoa Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}.
Q8WUM9 SLC20A1 S288 ochoa Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.
Q8WXW3 PIBF1 S703 ochoa Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.
Q8WYP5 AHCTF1 S1847 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92610 ZNF592 S1227 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92625 ANKS1A S666 ochoa Ankyrin repeat and SAM domain-containing protein 1A (Odin) Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}.
Q93074 MED12 S665 ochoa Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}.
Q96EV2 RBM33 S233 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q9BQF6 SENP7 S25 ochoa Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}.
Q9BV73 CEP250 S1991 ochoa Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}.
Q9BVJ6 UTP14A S51 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9BVS4 RIOK2 S370 ochoa Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
Q9BVS4 RIOK2 S380 ochoa|psp Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
Q9BX40 LSM14B S323 ochoa Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}.
Q9BXL6 CARD14 S241 ochoa Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}.
Q9BZI7 UPF3B S415 ochoa Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Q9H0A0 NAT10 S934 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H7D0 DOCK5 S1742 ochoa Dedicator of cytokinesis protein 5 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.
Q9H8G2 CAAP1 S203 ochoa Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}.
Q9HAW4 CLSPN S958 ochoa Claspin (hClaspin) Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
Q9HC44 GPBP1L1 S382 ochoa Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) Possible transcription factor. {ECO:0000305}.
Q9NRY4 ARHGAP35 S1006 ochoa Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.
Q9NRY5 FAM114A2 S209 ochoa Protein FAM114A2 None
Q9NS23 RASSF1 S135 psp Ras association domain-containing protein 1 Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}.
Q9NVF7 FBXO28 S338 ochoa F-box only protein 28 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}.
Q9NVI7 ATAD3A S168 ochoa ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}.
Q9NW68 BSDC1 S79 ochoa BSD domain-containing protein 1 None
Q9P0K7 RAI14 S482 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P219 CCDC88C S486 ochoa Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}.
Q9P246 STIM2 S343 ochoa Stromal interaction molecule 2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Q9UEU0 VTI1B S185 ochoa Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}.
Q9UJX4 ANAPC5 S195 ochoa Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9UKI8 TLK1 S357 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9UKX2 MYH2 S1146 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULD2 MTUS1 S1224 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9UNE0 EDAR S273 ochoa Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Q9UPV0 CEP164 S383 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UPV7 PHF24 S241 ochoa PHD finger protein 24 None
Q9UQ35 SRRM2 S1257 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y426 C2CD2 S581 ochoa C2 domain-containing protein 2 (Transmembrane protein 24-like) None
Q9Y623 MYH4 S1144 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
P33176 KIF5B S527 Sugiyama Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.
Q14444 CAPRIN1 S200 Sugiyama Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}.
O43293 DAPK3 S371 Sugiyama Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}.
P09497 CLTB S144 Sugiyama Clathrin light chain B (Lcb) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Q02878 RPL6 S255 Sugiyama Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}.
Q12906 ILF3 S46 Sugiyama Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
Q8NE71 ABCF1 S285 Sugiyama ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.
Q99816 TSG101 S299 Sugiyama Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.
O95259 KCNH1 S952 Sugiyama Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25420144, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:25915598, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:30149017, ECO:0000269|PubMed:9738473}.
P16949 STMN1 S94 Sugiyama Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
O75496 GMNN Y111 Sugiyama Geminin Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}.
Q9UH65 SWAP70 S409 Sugiyama Switch-associated protein 70 (SWAP-70) Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
Q9BQS8 FYCO1 S425 Sugiyama FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}.
Q7KZI7 MARK2 S704 Sugiyama Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q9UK32 RPS6KA6 S318 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
Download
reactome_id name p -log10_p
R-HSA-1640170 Cell Cycle 0.000001 5.914
R-HSA-69620 Cell Cycle Checkpoints 0.000002 5.619
R-HSA-390522 Striated Muscle Contraction 0.000019 4.728
R-HSA-68877 Mitotic Prometaphase 0.000052 4.283
R-HSA-68886 M Phase 0.000090 4.043
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.000186 3.730
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.000271 3.567
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.000271 3.567
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.000280 3.552
R-HSA-983189 Kinesins 0.000223 3.652
R-HSA-176187 Activation of ATR in response to replication stress 0.000280 3.552
R-HSA-69481 G2/M Checkpoints 0.000147 3.832
R-HSA-400685 Sema4D in semaphorin signaling 0.000118 3.930
R-HSA-69278 Cell Cycle, Mitotic 0.000236 3.627
R-HSA-8854518 AURKA Activation by TPX2 0.000327 3.485
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.000338 3.471
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.000338 3.471
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.000370 3.431
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.000492 3.308
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.000479 3.319
R-HSA-69473 G2/M DNA damage checkpoint 0.000520 3.284
R-HSA-380287 Centrosome maturation 0.000549 3.260
R-HSA-5693607 Processing of DNA double-strand break ends 0.000750 3.125
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.000869 3.061
R-HSA-9675135 Diseases of DNA repair 0.000941 3.026
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.001080 2.966
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.001097 2.960
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.001200 2.921
R-HSA-445355 Smooth Muscle Contraction 0.001469 2.833
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.001684 2.774
R-HSA-69618 Mitotic Spindle Checkpoint 0.001974 2.705
R-HSA-3928663 EPHA-mediated growth cone collapse 0.002374 2.625
R-HSA-373755 Semaphorin interactions 0.002539 2.595
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.003086 2.511
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.003389 2.470
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.003528 2.453
R-HSA-5693538 Homology Directed Repair 0.004121 2.385
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.004582 2.339
R-HSA-2132295 MHC class II antigen presentation 0.004811 2.318
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.004877 2.312
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.004995 2.301
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.005627 2.250
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.006230 2.206
R-HSA-8856688 Golgi-to-ER retrograde transport 0.006614 2.180
R-HSA-141424 Amplification of signal from the kinetochores 0.006796 2.168
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.006796 2.168
R-HSA-199991 Membrane Trafficking 0.006832 2.165
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.007047 2.152
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.008100 2.092
R-HSA-2682334 EPH-Ephrin signaling 0.008982 2.047
R-HSA-397014 Muscle contraction 0.010549 1.977
R-HSA-5693532 DNA Double-Strand Break Repair 0.011819 1.927
R-HSA-9673013 Diseases of Telomere Maintenance 0.015651 1.805
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.015651 1.805
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.015651 1.805
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.015651 1.805
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.015651 1.805
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.015651 1.805
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.015651 1.805
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.015711 1.804
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.016961 1.771
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.016961 1.771
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.016961 1.771
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.016961 1.771
R-HSA-2467813 Separation of Sister Chromatids 0.015087 1.821
R-HSA-72312 rRNA processing 0.015282 1.816
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.015884 1.799
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.017454 1.758
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.019060 1.720
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.025295 1.597
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.022651 1.645
R-HSA-5617833 Cilium Assembly 0.025539 1.593
R-HSA-69275 G2/M Transition 0.023760 1.624
R-HSA-453274 Mitotic G2-G2/M phases 0.024639 1.608
R-HSA-9675108 Nervous system development 0.021470 1.668
R-HSA-69052 Switching of origins to a post-replicative state 0.026754 1.573
R-HSA-5653656 Vesicle-mediated transport 0.031248 1.505
R-HSA-9615710 Late endosomal microautophagy 0.031597 1.500
R-HSA-68962 Activation of the pre-replicative complex 0.033259 1.478
R-HSA-5693537 Resolution of D-Loop Structures 0.040239 1.395
R-HSA-9675126 Diseases of mitotic cell cycle 0.036685 1.436
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.038446 1.415
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.038672 1.413
R-HSA-68882 Mitotic Anaphase 0.039777 1.400
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.040381 1.394
R-HSA-422475 Axon guidance 0.035790 1.446
R-HSA-3700989 Transcriptional Regulation by TP53 0.039290 1.406
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.046227 1.335
R-HSA-68867 Assembly of the pre-replicative complex 0.048653 1.313
R-HSA-8953750 Transcriptional Regulation by E2F6 0.051632 1.287
R-HSA-5633007 Regulation of TP53 Activity 0.053153 1.274
R-HSA-1251985 Nuclear signaling by ERBB4 0.053631 1.271
R-HSA-427652 Sodium-coupled phosphate cotransporters 0.061159 1.214
R-HSA-444257 RSK activation 0.083125 1.080
R-HSA-196025 Formation of annular gap junctions 0.083125 1.080
R-HSA-190873 Gap junction degradation 0.090332 1.044
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.070026 1.155
R-HSA-72163 mRNA Splicing - Major Pathway 0.088903 1.051
R-HSA-72613 Eukaryotic Translation Initiation 0.084261 1.074
R-HSA-69002 DNA Replication Pre-Initiation 0.071396 1.146
R-HSA-72737 Cap-dependent Translation Initiation 0.084261 1.074
R-HSA-176974 Unwinding of DNA 0.090332 1.044
R-HSA-912446 Meiotic recombination 0.079587 1.099
R-HSA-437239 Recycling pathway of L1 0.070556 1.151
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.072781 1.138
R-HSA-9762293 Regulation of CDH11 gene transcription 0.090332 1.044
R-HSA-73894 DNA Repair 0.081199 1.090
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.090332 1.044
R-HSA-69239 Synthesis of DNA 0.068667 1.163
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.090332 1.044
R-HSA-72702 Ribosomal scanning and start codon recognition 0.091347 1.039
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.091347 1.039
R-HSA-9706019 RHOBTB3 ATPase cycle 0.104580 0.981
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.125537 0.901
R-HSA-176412 Phosphorylation of the APC/C 0.146007 0.836
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.146007 0.836
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.172563 0.763
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.172563 0.763
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.185532 0.732
R-HSA-6803529 FGFR2 alternative splicing 0.198300 0.703
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.204609 0.689
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.204609 0.689
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.229356 0.639
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.229356 0.639
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.235423 0.628
R-HSA-167287 HIV elongation arrest and recovery 0.235423 0.628
R-HSA-113418 Formation of the Early Elongation Complex 0.235423 0.628
R-HSA-167290 Pausing and recovery of HIV elongation 0.235423 0.628
R-HSA-72689 Formation of a pool of free 40S subunits 0.204002 0.690
R-HSA-72172 mRNA Splicing 0.102044 0.991
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.166002 0.780
R-HSA-72086 mRNA Capping 0.241442 0.617
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.098632 1.006
R-HSA-5693606 DNA Double Strand Break Response 0.118798 0.925
R-HSA-6807878 COPI-mediated anterograde transport 0.206869 0.684
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.256098 0.592
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.191941 0.717
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.256098 0.592
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.111620 0.952
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.265052 0.577
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.211316 0.675
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.159389 0.798
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.244460 0.612
R-HSA-9614085 FOXO-mediated transcription 0.215497 0.667
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.223242 0.651
R-HSA-525793 Myogenesis 0.223242 0.651
R-HSA-9930044 Nuclear RNA decay 0.265052 0.577
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.097484 1.011
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.125537 0.901
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.152725 0.816
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.166002 0.780
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.172563 0.763
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.241442 0.617
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.241442 0.617
R-HSA-162588 Budding and maturation of HIV virion 0.253340 0.596
R-HSA-9613829 Chaperone Mediated Autophagy 0.166002 0.780
R-HSA-1500620 Meiosis 0.167244 0.777
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.132414 0.878
R-HSA-111447 Activation of BAD and translocation to mitochondria 0.139237 0.856
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.146007 0.836
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.198300 0.703
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.223242 0.651
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.253340 0.596
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 0.111620 0.952
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.152725 0.816
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 0.172563 0.763
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.185532 0.732
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.210869 0.676
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.247414 0.607
R-HSA-69306 DNA Replication 0.153403 0.814
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.210869 0.676
R-HSA-8863678 Neurodegenerative Diseases 0.210869 0.676
R-HSA-8953854 Metabolism of RNA 0.139356 0.856
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.111620 0.952
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.139237 0.856
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.223242 0.651
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.229356 0.639
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.118606 0.926
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.111620 0.952
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.125537 0.901
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 0.139237 0.856
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.146007 0.836
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.229356 0.639
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.125537 0.901
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.139237 0.856
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.146007 0.836
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.204609 0.689
R-HSA-5689901 Metalloprotease DUBs 0.223242 0.651
R-HSA-5669034 TNFs bind their physiological receptors 0.210869 0.676
R-HSA-9659379 Sensory processing of sound 0.150708 0.822
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.139237 0.856
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.235423 0.628
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.241442 0.617
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.121388 0.916
R-HSA-69190 DNA strand elongation 0.259219 0.586
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.241553 0.617
R-HSA-175474 Assembly Of The HIV Virion 0.191941 0.717
R-HSA-166208 mTORC1-mediated signalling 0.198300 0.703
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.265052 0.577
R-HSA-9700206 Signaling by ALK in cancer 0.241553 0.617
R-HSA-69242 S Phase 0.144178 0.841
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.223242 0.651
R-HSA-114452 Activation of BH3-only proteins 0.247414 0.607
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.131880 0.880
R-HSA-1852241 Organelle biogenesis and maintenance 0.132261 0.879
R-HSA-373760 L1CAM interactions 0.273574 0.563
R-HSA-381042 PERK regulates gene expression 0.282280 0.549
R-HSA-6794362 Protein-protein interactions at synapses 0.167244 0.777
R-HSA-1181150 Signaling by NODAL 0.179073 0.747
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.223242 0.651
R-HSA-264876 Insulin processing 0.229356 0.639
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.204609 0.689
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.249143 0.604
R-HSA-1236394 Signaling by ERBB4 0.137203 0.863
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.270840 0.567
R-HSA-109581 Apoptosis 0.170461 0.768
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.259219 0.586
R-HSA-8986944 Transcriptional Regulation by MECP2 0.186904 0.728
R-HSA-5357801 Programmed Cell Death 0.262134 0.581
R-HSA-9730414 MITF-M-regulated melanocyte development 0.279145 0.554
R-HSA-9682385 FLT3 signaling in disease 0.287933 0.541
R-HSA-432720 Lysosome Vesicle Biogenesis 0.287933 0.541
R-HSA-1839126 FGFR2 mutant receptor activation 0.287933 0.541
R-HSA-73886 Chromosome Maintenance 0.288128 0.540
R-HSA-1296072 Voltage gated Potassium channels 0.293542 0.532
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.299107 0.524
R-HSA-69206 G1/S Transition 0.302652 0.519
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.304628 0.516
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.310107 0.508
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.310107 0.508
R-HSA-167169 HIV Transcription Elongation 0.310107 0.508
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.310107 0.508
R-HSA-9646399 Aggrephagy 0.310107 0.508
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.310107 0.508
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.315542 0.501
R-HSA-9607240 FLT3 Signaling 0.315542 0.501
R-HSA-8853884 Transcriptional Regulation by VENTX 0.315542 0.501
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.315542 0.501
R-HSA-1474165 Reproduction 0.320013 0.495
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.320935 0.494
R-HSA-167161 HIV Transcription Initiation 0.320935 0.494
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.320935 0.494
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.320935 0.494
R-HSA-165159 MTOR signalling 0.326286 0.486
R-HSA-73776 RNA Polymerase II Promoter Escape 0.331595 0.479
R-HSA-190828 Gap junction trafficking 0.336863 0.473
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.342089 0.466
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.342089 0.466
R-HSA-774815 Nucleosome assembly 0.342089 0.466
R-HSA-72165 mRNA Splicing - Minor Pathway 0.347275 0.459
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.347275 0.459
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.347275 0.459
R-HSA-75153 Apoptotic execution phase 0.347275 0.459
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.352420 0.453
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.352420 0.453
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.352420 0.453
R-HSA-162599 Late Phase of HIV Life Cycle 0.360078 0.444
R-HSA-157858 Gap junction trafficking and regulation 0.362589 0.441
R-HSA-5655253 Signaling by FGFR2 in disease 0.367614 0.435
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.371377 0.430
R-HSA-199977 ER to Golgi Anterograde Transport 0.374189 0.427
R-HSA-72187 mRNA 3'-end processing 0.377547 0.423
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.377547 0.423
R-HSA-112382 Formation of RNA Pol II elongation complex 0.377547 0.423
R-HSA-68949 Orc1 removal from chromatin 0.377547 0.423
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.377547 0.423
R-HSA-6794361 Neurexins and neuroligins 0.377547 0.423
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.382455 0.417
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.382455 0.417
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.382455 0.417
R-HSA-1221632 Meiotic synapsis 0.382455 0.417
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.382455 0.417
R-HSA-9856651 MITF-M-dependent gene expression 0.382597 0.417
R-HSA-72649 Translation initiation complex formation 0.387325 0.412
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.387325 0.412
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.388175 0.411
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.392157 0.407
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.396502 0.402
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.396951 0.401
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.396951 0.401
R-HSA-9612973 Autophagy 0.399266 0.399
R-HSA-162587 HIV Life Cycle 0.402025 0.396
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.406426 0.391
R-HSA-429914 Deadenylation-dependent mRNA decay 0.411108 0.386
R-HSA-73856 RNA Polymerase II Transcription Termination 0.420363 0.376
R-HSA-168325 Viral Messenger RNA Synthesis 0.420363 0.376
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.424936 0.372
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.424936 0.372
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.429474 0.367
R-HSA-8848021 Signaling by PTK6 0.429474 0.367
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.438442 0.358
R-HSA-162582 Signal Transduction 0.449905 0.347
R-HSA-109582 Hemostasis 0.450949 0.346
R-HSA-167172 Transcription of the HIV genome 0.451633 0.345
R-HSA-204005 COPII-mediated vesicle transport 0.460256 0.337
R-HSA-168255 Influenza Infection 0.463705 0.334
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.464516 0.333
R-HSA-453276 Regulation of mitotic cell cycle 0.464516 0.333
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.464516 0.333
R-HSA-2559583 Cellular Senescence 0.466304 0.331
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.468744 0.329
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.468744 0.329
R-HSA-212436 Generic Transcription Pathway 0.472677 0.325
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.472938 0.325
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.472938 0.325
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.477099 0.321
R-HSA-1226099 Signaling by FGFR in disease 0.477099 0.321
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.481228 0.318
R-HSA-8852135 Protein ubiquitination 0.481228 0.318
R-HSA-73857 RNA Polymerase II Transcription 0.487755 0.312
R-HSA-1266738 Developmental Biology 0.488551 0.311
R-HSA-4086400 PCP/CE pathway 0.493422 0.307
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.496903 0.304
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.501392 0.300
R-HSA-5654738 Signaling by FGFR2 0.501392 0.300
R-HSA-9833482 PKR-mediated signaling 0.501392 0.300
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.509238 0.293
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.509238 0.293
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.513115 0.290
R-HSA-6802957 Oncogenic MAPK signaling 0.520778 0.283
R-HSA-5687128 MAPK6/MAPK4 signaling 0.520778 0.283
R-HSA-948021 Transport to the Golgi and subsequent modification 0.521546 0.283
R-HSA-376176 Signaling by ROBO receptors 0.523966 0.281
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.524565 0.280
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.524565 0.280
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.528322 0.277
R-HSA-438064 Post NMDA receptor activation events 0.532049 0.274
R-HSA-156902 Peptide chain elongation 0.535747 0.271
R-HSA-9663891 Selective autophagy 0.535747 0.271
R-HSA-9645723 Diseases of programmed cell death 0.535747 0.271
R-HSA-112316 Neuronal System 0.540699 0.267
R-HSA-112310 Neurotransmitter release cycle 0.543057 0.265
R-HSA-73884 Base Excision Repair 0.543057 0.265
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.546669 0.262
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.550252 0.259
R-HSA-156842 Eukaryotic Translation Elongation 0.553808 0.257
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.564307 0.248
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.567753 0.246
R-HSA-72764 Eukaryotic Translation Termination 0.567753 0.246
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.571171 0.243
R-HSA-1296071 Potassium Channels 0.571171 0.243
R-HSA-157579 Telomere Maintenance 0.574562 0.241
R-HSA-8878159 Transcriptional regulation by RUNX3 0.574562 0.241
R-HSA-8957275 Post-translational protein phosphorylation 0.577927 0.238
R-HSA-190236 Signaling by FGFR 0.577927 0.238
R-HSA-162906 HIV Infection 0.581777 0.235
R-HSA-5610787 Hedgehog 'off' state 0.584577 0.233
R-HSA-382556 ABC-family proteins mediated transport 0.584577 0.233
R-HSA-2408557 Selenocysteine synthesis 0.587863 0.231
R-HSA-9009391 Extra-nuclear estrogen signaling 0.587863 0.231
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.591123 0.228
R-HSA-192823 Viral mRNA Translation 0.594358 0.226
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.597568 0.224
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.597568 0.224
R-HSA-9833110 RSV-host interactions 0.600752 0.221
R-HSA-8939211 ESR-mediated signaling 0.603429 0.219
R-HSA-9692914 SARS-CoV-1-host interactions 0.607045 0.217
R-HSA-1280218 Adaptive Immune System 0.609744 0.215
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.610155 0.215
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.613240 0.212
R-HSA-2672351 Stimuli-sensing channels 0.613240 0.212
R-HSA-6803157 Antimicrobial peptides 0.622352 0.206
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.634170 0.198
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.637066 0.196
R-HSA-5688426 Deubiquitination 0.640267 0.194
R-HSA-9007101 Rab regulation of trafficking 0.645620 0.190
R-HSA-2980736 Peptide hormone metabolism 0.645620 0.190
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.648427 0.188
R-HSA-68875 Mitotic Prophase 0.653975 0.184
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.670101 0.174
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.670101 0.174
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.670101 0.174
R-HSA-114608 Platelet degranulation 0.675309 0.170
R-HSA-9843745 Adipogenesis 0.687975 0.162
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.690449 0.161
R-HSA-72766 Translation 0.692099 0.160
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.692903 0.159
R-HSA-3858494 Beta-catenin independent WNT signaling 0.702529 0.153
R-HSA-9018519 Estrogen-dependent gene expression 0.702529 0.153
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.704888 0.152
R-HSA-9948299 Ribosome-associated quality control 0.707229 0.150
R-HSA-5358351 Signaling by Hedgehog 0.707229 0.150
R-HSA-381119 Unfolded Protein Response (UPR) 0.709551 0.149
R-HSA-9664407 Parasite infection 0.711855 0.148
R-HSA-9664417 Leishmania phagocytosis 0.711855 0.148
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.711855 0.148
R-HSA-1632852 Macroautophagy 0.714141 0.146
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.714141 0.146
R-HSA-74160 Gene expression (Transcription) 0.715341 0.145
R-HSA-195721 Signaling by WNT 0.717403 0.144
R-HSA-8856828 Clathrin-mediated endocytosis 0.720891 0.142
R-HSA-6798695 Neutrophil degranulation 0.730562 0.136
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.738128 0.132
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.744316 0.128
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.744316 0.128
R-HSA-1989781 PPARA activates gene expression 0.746347 0.127
R-HSA-9610379 HCMV Late Events 0.750359 0.125
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.750359 0.125
R-HSA-9711097 Cellular response to starvation 0.752342 0.124
R-HSA-112315 Transmission across Chemical Synapses 0.755585 0.122
R-HSA-2408522 Selenoamino acid metabolism 0.763914 0.117
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.780273 0.108
R-HSA-5689880 Ub-specific processing proteases 0.782020 0.107
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.783753 0.106
R-HSA-9678108 SARS-CoV-1 Infection 0.785472 0.105
R-HSA-201681 TCF dependent signaling in response to WNT 0.798748 0.098
R-HSA-375276 Peptide ligand-binding receptors 0.803513 0.095
R-HSA-9006931 Signaling by Nuclear Receptors 0.807478 0.093
R-HSA-983712 Ion channel transport 0.808166 0.092
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.818603 0.087
R-HSA-389948 Co-inhibition by PD-1 0.824312 0.084
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.830633 0.081
R-HSA-2262752 Cellular responses to stress 0.834903 0.078
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.841663 0.075
R-HSA-418990 Adherens junctions interactions 0.849087 0.071
R-HSA-8951664 Neddylation 0.852668 0.069
R-HSA-9705683 SARS-CoV-2-host interactions 0.860700 0.065
R-HSA-446203 Asparagine N-linked glycosylation 0.867122 0.062
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.880382 0.055
R-HSA-9609646 HCMV Infection 0.883221 0.054
R-HSA-421270 Cell-cell junction organization 0.884154 0.053
R-HSA-388841 Regulation of T cell activation by CD28 family 0.888709 0.051
R-HSA-9734767 Developmental Cell Lineages 0.894789 0.048
R-HSA-9711123 Cellular response to chemical stress 0.898929 0.046
R-HSA-76002 Platelet activation, signaling and aggregation 0.903685 0.044
R-HSA-8953897 Cellular responses to stimuli 0.904274 0.044
R-HSA-168256 Immune System 0.905980 0.043
R-HSA-446728 Cell junction organization 0.906731 0.043
R-HSA-9658195 Leishmania infection 0.908952 0.041
R-HSA-9824443 Parasitic Infection Pathways 0.908952 0.041
R-HSA-1257604 PIP3 activates AKT signaling 0.918646 0.037
R-HSA-1643685 Disease 0.922903 0.035
R-HSA-1500931 Cell-Cell communication 0.931298 0.031
R-HSA-212165 Epigenetic regulation of gene expression 0.935065 0.029
R-HSA-1474244 Extracellular matrix organization 0.939120 0.027
R-HSA-9006925 Intracellular signaling by second messengers 0.944289 0.025
R-HSA-5683057 MAPK family signaling cascades 0.946492 0.024
R-HSA-9694516 SARS-CoV-2 Infection 0.947349 0.023
R-HSA-9824446 Viral Infection Pathways 0.952716 0.021
R-HSA-913531 Interferon Signaling 0.960319 0.018
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.963699 0.016
R-HSA-425407 SLC-mediated transmembrane transport 0.964570 0.016
R-HSA-449147 Signaling by Interleukins 0.965197 0.015
R-HSA-418594 G alpha (i) signalling events 0.967326 0.014
R-HSA-1280215 Cytokine Signaling in Immune system 0.976192 0.010
R-HSA-168249 Innate Immune System 0.984303 0.007
R-HSA-382551 Transport of small molecules 0.987223 0.006
R-HSA-9679506 SARS-CoV Infections 0.990206 0.004
R-HSA-500792 GPCR ligand binding 0.992586 0.003
R-HSA-597592 Post-translational protein modification 0.993297 0.003
R-HSA-71291 Metabolism of amino acids and derivatives 0.994156 0.003
R-HSA-5663205 Infectious disease 0.994431 0.002
R-HSA-392499 Metabolism of proteins 0.995072 0.002
R-HSA-388396 GPCR downstream signalling 0.998388 0.001
R-HSA-372790 Signaling by GPCR 0.999192 0.000
R-HSA-9709957 Sensory Perception 0.999616 0.000
R-HSA-556833 Metabolism of lipids 0.999996 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.797 0.137 2 0.818
CDC7CDC7 0.794 0.115 1 0.848
FAM20CFAM20C 0.793 0.235 2 0.765
ATMATM 0.788 0.206 1 0.787
SKMLCKSKMLCK 0.786 0.186 -2 0.814
RSK2RSK2 0.784 0.094 -3 0.737
DSTYKDSTYK 0.783 0.073 2 0.848
MOSMOS 0.783 0.067 1 0.830
GCN2GCN2 0.783 -0.051 2 0.762
TGFBR2TGFBR2 0.783 0.076 -2 0.807
PRKD2PRKD2 0.783 0.076 -3 0.738
PIM3PIM3 0.783 0.037 -3 0.769
CAMK1BCAMK1B 0.782 0.056 -3 0.804
PRKD1PRKD1 0.781 0.045 -3 0.749
NDR2NDR2 0.781 0.023 -3 0.762
ATRATR 0.780 0.103 1 0.797
RIPK3RIPK3 0.780 0.123 3 0.691
RAF1RAF1 0.779 -0.009 1 0.739
PRPKPRPK 0.779 -0.041 -1 0.744
NDR1NDR1 0.779 0.038 -3 0.771
CAMLCKCAMLCK 0.778 0.118 -2 0.830
CLK3CLK3 0.778 0.052 1 0.680
P90RSKP90RSK 0.778 0.063 -3 0.738
BMPR2BMPR2 0.777 0.066 -2 0.842
PIM1PIM1 0.777 0.079 -3 0.753
MAPKAPK2MAPKAPK2 0.777 0.068 -3 0.699
CAMK2GCAMK2G 0.776 0.037 2 0.804
PKN3PKN3 0.776 0.019 -3 0.762
MAPKAPK3MAPKAPK3 0.776 0.042 -3 0.720
ULK2ULK2 0.776 -0.103 2 0.757
TSSK2TSSK2 0.776 0.043 -5 0.810
DAPK2DAPK2 0.775 0.112 -3 0.790
CAMK2BCAMK2B 0.775 0.115 2 0.798
BMPR1BBMPR1B 0.775 0.150 1 0.772
LATS2LATS2 0.775 0.038 -5 0.747
GRK6GRK6 0.774 0.081 1 0.758
NEK7NEK7 0.774 -0.013 -3 0.729
TBK1TBK1 0.774 -0.054 1 0.605
RSK3RSK3 0.773 0.051 -3 0.727
CDKL1CDKL1 0.773 0.027 -3 0.750
NEK6NEK6 0.772 -0.034 -2 0.840
IKKBIKKB 0.772 -0.048 -2 0.678
MSK2MSK2 0.772 0.067 -3 0.698
P70S6KBP70S6KB 0.772 0.054 -3 0.754
NIM1NIM1 0.772 0.010 3 0.659
WNK1WNK1 0.771 -0.007 -2 0.787
NUAK2NUAK2 0.771 -0.001 -3 0.794
WNK3WNK3 0.771 -0.031 1 0.717
PRKD3PRKD3 0.771 0.061 -3 0.721
AMPKA1AMPKA1 0.771 -0.009 -3 0.786
PKACGPKACG 0.771 0.052 -2 0.753
NLKNLK 0.770 -0.017 1 0.640
MARK4MARK4 0.770 -0.038 4 0.611
NIKNIK 0.770 -0.007 -3 0.800
PAK6PAK6 0.770 0.102 -2 0.710
PDHK4PDHK4 0.770 -0.156 1 0.736
IKKEIKKE 0.770 -0.068 1 0.598
CAMK4CAMK4 0.770 0.032 -3 0.771
MYLK4MYLK4 0.770 0.112 -2 0.773
TSSK1TSSK1 0.770 0.008 -3 0.794
AURCAURC 0.770 0.069 -2 0.695
ACVR2AACVR2A 0.770 0.149 -2 0.801
PKCDPKCD 0.769 0.012 2 0.744
ACVR2BACVR2B 0.769 0.161 -2 0.806
CAMK2DCAMK2D 0.769 0.024 -3 0.756
AURBAURB 0.768 0.089 -2 0.694
HUNKHUNK 0.768 -0.082 2 0.758
PKACBPKACB 0.768 0.097 -2 0.716
MSK1MSK1 0.768 0.096 -3 0.699
ALK2ALK2 0.768 0.155 -2 0.761
PAK1PAK1 0.767 0.054 -2 0.771
PLK1PLK1 0.767 0.079 -2 0.846
MLK1MLK1 0.767 -0.032 2 0.760
AMPKA2AMPKA2 0.767 -0.003 -3 0.768
GRK4GRK4 0.767 0.012 -2 0.768
PAK3PAK3 0.767 0.038 -2 0.773
MNK2MNK2 0.767 0.038 -2 0.790
RSK4RSK4 0.767 0.078 -3 0.716
SMG1SMG1 0.767 0.178 1 0.777
ULK1ULK1 0.767 -0.103 -3 0.724
MELKMELK 0.766 0.020 -3 0.752
SRPK1SRPK1 0.766 0.022 -3 0.719
NUAK1NUAK1 0.766 0.001 -3 0.753
PKN2PKN2 0.766 -0.016 -3 0.778
GRK5GRK5 0.766 -0.053 -3 0.751
TGFBR1TGFBR1 0.766 0.082 -2 0.751
NEK9NEK9 0.766 -0.039 2 0.783
MST4MST4 0.765 -0.032 2 0.753
BMPR1ABMPR1A 0.765 0.149 1 0.773
GRK1GRK1 0.765 0.048 -2 0.698
SIKSIK 0.765 0.014 -3 0.726
LATS1LATS1 0.764 0.077 -3 0.756
CDKL5CDKL5 0.764 -0.003 -3 0.741
SRPK2SRPK2 0.764 0.031 -3 0.660
IRE2IRE2 0.764 -0.016 2 0.714
ERK5ERK5 0.764 -0.024 1 0.598
PRKXPRKX 0.763 0.104 -3 0.675
AURAAURA 0.763 0.081 -2 0.675
DNAPKDNAPK 0.763 0.126 1 0.688
CAMK2ACAMK2A 0.763 0.043 2 0.781
ALK4ALK4 0.763 0.057 -2 0.775
PKG2PKG2 0.762 0.071 -2 0.713
BCKDKBCKDK 0.762 -0.106 -1 0.703
PDHK1PDHK1 0.762 -0.203 1 0.711
HIPK4HIPK4 0.762 -0.031 1 0.646
MTORMTOR 0.762 -0.182 1 0.641
IKKAIKKA 0.761 -0.032 -2 0.667
PLK3PLK3 0.761 0.049 2 0.745
PAK2PAK2 0.761 0.044 -2 0.754
MNK1MNK1 0.760 0.040 -2 0.807
RIPK1RIPK1 0.760 -0.072 1 0.723
ANKRD3ANKRD3 0.760 -0.035 1 0.729
TTBK2TTBK2 0.760 -0.072 2 0.677
IRE1IRE1 0.759 -0.087 1 0.719
QSKQSK 0.759 -0.026 4 0.590
KISKIS 0.759 -0.018 1 0.484
CHK1CHK1 0.759 0.011 -3 0.748
SRPK3SRPK3 0.759 0.020 -3 0.695
QIKQIK 0.759 -0.055 -3 0.756
PKACAPKACA 0.758 0.096 -2 0.679
ICKICK 0.758 -0.019 -3 0.774
BRSK1BRSK1 0.758 -0.018 -3 0.741
CHAK2CHAK2 0.758 -0.090 -1 0.714
PIM2PIM2 0.758 0.052 -3 0.720
PKCBPKCB 0.757 -0.016 2 0.695
CLK4CLK4 0.757 0.051 -3 0.752
PKRPKR 0.757 -0.007 1 0.749
MARK2MARK2 0.757 -0.026 4 0.521
AKT2AKT2 0.757 0.059 -3 0.683
MLK3MLK3 0.757 -0.033 2 0.697
PHKG1PHKG1 0.756 -0.047 -3 0.766
MLK4MLK4 0.756 -0.009 2 0.703
DAPK3DAPK3 0.756 0.143 -3 0.763
MASTLMASTL 0.755 -0.155 -2 0.743
MLK2MLK2 0.755 -0.119 2 0.781
DLKDLK 0.755 -0.120 1 0.722
MAPKAPK5MAPKAPK5 0.755 -0.004 -3 0.663
CLK1CLK1 0.755 0.041 -3 0.739
CAMK1DCAMK1D 0.755 0.070 -3 0.668
SNRKSNRK 0.754 -0.070 2 0.656
SGK3SGK3 0.754 0.046 -3 0.710
SMMLCKSMMLCK 0.754 0.096 -3 0.764
PKCGPKCG 0.754 -0.032 2 0.680
PKCHPKCH 0.753 -0.027 2 0.684
MEK1MEK1 0.753 -0.028 2 0.791
CK2A2CK2A2 0.753 0.101 1 0.730
PKCAPKCA 0.752 -0.032 2 0.682
BRAFBRAF 0.752 0.019 -4 0.791
DCAMKL1DCAMKL1 0.752 0.015 -3 0.753
CAMK1GCAMK1G 0.752 0.006 -3 0.735
NEK2NEK2 0.752 -0.072 2 0.754
MARK1MARK1 0.752 -0.038 4 0.571
PAK5PAK5 0.751 0.066 -2 0.657
AKT1AKT1 0.751 0.065 -3 0.691
SSTKSSTK 0.751 -0.021 4 0.583
PERKPERK 0.751 -0.018 -2 0.812
HRIHRI 0.751 -0.043 -2 0.838
MARK3MARK3 0.751 -0.050 4 0.549
PAK4PAK4 0.750 0.076 -2 0.669
PLK4PLK4 0.750 -0.033 2 0.604
BRSK2BRSK2 0.750 -0.076 -3 0.752
DYRK2DYRK2 0.750 -0.022 1 0.520
GRK7GRK7 0.750 0.011 1 0.675
PHKG2PHKG2 0.750 -0.024 -3 0.770
TLK2TLK2 0.749 -0.048 1 0.745
IRAK4IRAK4 0.748 -0.043 1 0.722
PKCZPKCZ 0.748 -0.063 2 0.732
DRAK1DRAK1 0.748 -0.026 1 0.680
CLK2CLK2 0.748 0.059 -3 0.733
TLK1TLK1 0.748 -0.035 -2 0.808
CHAK1CHAK1 0.747 -0.115 2 0.718
P70S6KP70S6K 0.747 0.024 -3 0.676
PKCTPKCT 0.747 -0.018 2 0.698
YSK4YSK4 0.746 -0.108 1 0.665
GRK2GRK2 0.746 -0.011 -2 0.650
WNK4WNK4 0.745 -0.067 -2 0.765
DAPK1DAPK1 0.745 0.102 -3 0.752
CK1ECK1E 0.744 0.021 -3 0.586
MEKK2MEKK2 0.744 -0.024 2 0.770
DCAMKL2DCAMKL2 0.744 -0.008 -3 0.778
CDK8CDK8 0.744 -0.080 1 0.461
VRK2VRK2 0.743 -0.188 1 0.749
CAMK1ACAMK1A 0.743 0.054 -3 0.663
NEK5NEK5 0.743 -0.016 1 0.733
MEKK3MEKK3 0.743 -0.048 1 0.685
CDK7CDK7 0.742 -0.078 1 0.475
HIPK1HIPK1 0.742 -0.005 1 0.529
DYRK1ADYRK1A 0.741 -0.004 1 0.547
IRAK1IRAK1 0.741 -0.091 -1 0.681
CK2A1CK2A1 0.741 0.073 1 0.710
MEKK1MEKK1 0.741 -0.084 1 0.693
AKT3AKT3 0.740 0.058 -3 0.628
MEK5MEK5 0.739 -0.143 2 0.780
CDK18CDK18 0.739 -0.032 1 0.398
CHK2CHK2 0.739 0.044 -3 0.648
DYRK3DYRK3 0.739 0.025 1 0.544
ZAKZAK 0.738 -0.113 1 0.661
MRCKBMRCKB 0.738 0.075 -3 0.713
NEK8NEK8 0.738 -0.053 2 0.760
PKG1PKG1 0.738 0.063 -2 0.653
PKN1PKN1 0.737 0.002 -3 0.697
CDK19CDK19 0.737 -0.081 1 0.420
PLK2PLK2 0.737 0.047 -3 0.738
HIPK2HIPK2 0.736 -0.028 1 0.431
TTKTTK 0.736 0.190 -2 0.843
SGK1SGK1 0.736 0.066 -3 0.611
TTBK1TTBK1 0.736 -0.084 2 0.593
JNK2JNK2 0.736 -0.031 1 0.401
P38AP38A 0.735 -0.061 1 0.481
HIPK3HIPK3 0.735 -0.033 1 0.515
ROCK2ROCK2 0.735 0.074 -3 0.742
MRCKAMRCKA 0.735 0.064 -3 0.721
PASKPASK 0.735 -0.023 -3 0.774
CDK5CDK5 0.734 -0.085 1 0.497
PRP4PRP4 0.734 -0.046 -3 0.665
PINK1PINK1 0.734 -0.144 1 0.675
JNK3JNK3 0.733 -0.051 1 0.445
PKCIPKCI 0.733 -0.049 2 0.689
DYRK4DYRK4 0.733 -0.012 1 0.434
CDK14CDK14 0.733 -0.014 1 0.434
SBKSBK 0.733 0.050 -3 0.593
CDK17CDK17 0.733 -0.049 1 0.345
GRK3GRK3 0.733 -0.017 -2 0.603
MST3MST3 0.733 -0.065 2 0.747
CAMKK1CAMKK1 0.733 -0.092 -2 0.704
DYRK1BDYRK1B 0.733 -0.023 1 0.462
CK1DCK1D 0.733 0.022 -3 0.538
ERK2ERK2 0.732 -0.064 1 0.458
CDK16CDK16 0.732 -0.014 1 0.367
CK1A2CK1A2 0.732 0.020 -3 0.545
PKCEPKCE 0.732 -0.009 2 0.663
TAO3TAO3 0.731 -0.084 1 0.674
TAO2TAO2 0.731 -0.077 2 0.794
CK1G1CK1G1 0.731 -0.021 -3 0.568
NEK4NEK4 0.730 -0.065 1 0.686
DMPK1DMPK1 0.730 0.090 -3 0.747
CDK13CDK13 0.729 -0.105 1 0.445
P38BP38B 0.728 -0.053 1 0.404
GAKGAK 0.728 -0.038 1 0.702
ERK1ERK1 0.727 -0.065 1 0.394
ROCK1ROCK1 0.727 0.075 -3 0.724
CDK2CDK2 0.727 -0.111 1 0.509
GSK3BGSK3B 0.726 -0.083 4 0.257
P38GP38G 0.726 -0.061 1 0.335
MPSK1MPSK1 0.725 -0.101 1 0.653
LKB1LKB1 0.725 -0.123 -3 0.712
CDK1CDK1 0.724 -0.094 1 0.430
NEK1NEK1 0.724 -0.055 1 0.702
NEK11NEK11 0.724 -0.149 1 0.649
BUB1BUB1 0.724 0.003 -5 0.754
TAK1TAK1 0.724 -0.042 1 0.721
CDK9CDK9 0.724 -0.112 1 0.448
MEKK6MEKK6 0.723 -0.119 1 0.681
CAMKK2CAMKK2 0.723 -0.140 -2 0.701
RIPK2RIPK2 0.723 -0.112 1 0.624
PDK1PDK1 0.723 -0.090 1 0.654
TNIKTNIK 0.723 -0.067 3 0.630
GSK3AGSK3A 0.722 -0.079 4 0.273
EEF2KEEF2K 0.722 -0.092 3 0.582
CDK12CDK12 0.722 -0.104 1 0.414
LOKLOK 0.722 -0.071 -2 0.748
MST2MST2 0.721 -0.094 1 0.692
CRIKCRIK 0.721 0.057 -3 0.681
VRK1VRK1 0.721 -0.101 2 0.784
ERK7ERK7 0.720 -0.036 2 0.498
HGKHGK 0.720 -0.115 3 0.630
MEK2MEK2 0.720 -0.098 2 0.773
MINKMINK 0.719 -0.107 1 0.664
MAP3K15MAP3K15 0.718 -0.141 1 0.642
MOKMOK 0.718 -0.002 1 0.559
GCKGCK 0.718 -0.104 1 0.665
P38DP38D 0.718 -0.050 1 0.383
CDK3CDK3 0.718 -0.076 1 0.365
CDK10CDK10 0.716 -0.071 1 0.421
PDHK3_TYRPDHK3_TYR 0.716 0.109 4 0.701
LRRK2LRRK2 0.715 -0.169 2 0.783
EPHA6EPHA6 0.715 0.131 -1 0.761
YSK1YSK1 0.714 -0.113 2 0.748
MAKMAK 0.714 -0.006 -2 0.668
HPK1HPK1 0.713 -0.098 1 0.642
ALPHAK3ALPHAK3 0.712 0.046 -1 0.662
KHS1KHS1 0.712 -0.090 1 0.646
EPHB4EPHB4 0.711 0.150 -1 0.778
STK33STK33 0.711 -0.136 2 0.566
NEK3NEK3 0.711 -0.141 1 0.643
MST1MST1 0.711 -0.137 1 0.671
PBKPBK 0.710 -0.076 1 0.627
SLKSLK 0.710 -0.109 -2 0.679
TXKTXK 0.709 0.178 1 0.771
KHS2KHS2 0.709 -0.077 1 0.650
JNK1JNK1 0.709 -0.065 1 0.397
CDK4CDK4 0.709 -0.085 1 0.405
BIKEBIKE 0.709 -0.011 1 0.572
MERTKMERTK 0.708 0.232 3 0.712
HASPINHASPIN 0.708 -0.051 -1 0.568
TNK2TNK2 0.708 0.166 3 0.729
FERFER 0.707 0.123 1 0.795
ABL2ABL2 0.707 0.094 -1 0.732
TESK1_TYRTESK1_TYR 0.707 -0.087 3 0.679
SRMSSRMS 0.707 0.192 1 0.785
TYRO3TYRO3 0.706 0.078 3 0.660
AXLAXL 0.706 0.194 3 0.728
INSRRINSRR 0.706 0.121 3 0.662
PDHK4_TYRPDHK4_TYR 0.705 0.006 2 0.822
MAP2K6_TYRMAP2K6_TYR 0.705 -0.009 -1 0.750
EPHB2EPHB2 0.704 0.139 -1 0.768
EPHB3EPHB3 0.704 0.135 -1 0.774
BLKBLK 0.704 0.182 -1 0.746
MAP2K4_TYRMAP2K4_TYR 0.704 -0.065 -1 0.763
YES1YES1 0.704 0.103 -1 0.755
OSR1OSR1 0.704 -0.099 2 0.738
CDK6CDK6 0.703 -0.103 1 0.413
PINK1_TYRPINK1_TYR 0.703 -0.082 1 0.731
ROS1ROS1 0.703 0.043 3 0.657
EPHB1EPHB1 0.703 0.123 1 0.770
MYO3BMYO3B 0.703 -0.085 2 0.756
RETRET 0.703 -0.012 1 0.687
TECTEC 0.703 0.148 -1 0.741
EPHA4EPHA4 0.702 0.103 2 0.730
LCKLCK 0.702 0.114 -1 0.746
CSF1RCSF1R 0.702 0.076 3 0.699
MAP2K7_TYRMAP2K7_TYR 0.702 -0.156 2 0.817
YANK3YANK3 0.701 -0.048 2 0.358
EPHA1EPHA1 0.701 0.166 3 0.713
MYO3AMYO3A 0.701 -0.081 1 0.679
ABL1ABL1 0.701 0.052 -1 0.730
PDHK1_TYRPDHK1_TYR 0.700 -0.047 -1 0.760
TYK2TYK2 0.700 -0.031 1 0.684
HCKHCK 0.700 0.101 -1 0.760
MST1RMST1R 0.700 0.013 3 0.704
TAO1TAO1 0.700 -0.104 1 0.613
LIMK2_TYRLIMK2_TYR 0.700 -0.079 -3 0.779
ASK1ASK1 0.699 -0.117 1 0.633
EPHA7EPHA7 0.699 0.130 2 0.739
BMPR2_TYRBMPR2_TYR 0.698 -0.063 -1 0.740
EPHA5EPHA5 0.698 0.157 2 0.740
JAK3JAK3 0.698 0.004 1 0.685
PKMYT1_TYRPKMYT1_TYR 0.697 -0.163 3 0.677
DDR1DDR1 0.697 -0.004 4 0.615
LTKLTK 0.697 0.065 3 0.644
JAK2JAK2 0.696 -0.024 1 0.664
FGFR2FGFR2 0.696 0.057 3 0.706
FLT3FLT3 0.696 0.011 3 0.660
ITKITK 0.695 0.046 -1 0.754
BMXBMX 0.695 0.085 -1 0.704
KDRKDR 0.695 0.061 3 0.700
PDGFRBPDGFRB 0.695 0.001 3 0.689
TEKTEK 0.694 0.052 3 0.648
LIMK1_TYRLIMK1_TYR 0.694 -0.179 2 0.814
ALKALK 0.693 0.026 3 0.624
KITKIT 0.693 0.025 3 0.696
EPHA3EPHA3 0.692 0.051 2 0.717
AAK1AAK1 0.692 -0.002 1 0.463
BTKBTK 0.692 0.046 -1 0.759
CK1ACK1A 0.691 -0.024 -3 0.467
STLK3STLK3 0.691 -0.113 1 0.643
FGRFGR 0.691 -0.058 1 0.728
FRKFRK 0.691 0.071 -1 0.791
JAK1JAK1 0.690 0.034 1 0.622
METMET 0.690 0.021 3 0.709
FGFR1FGFR1 0.689 -0.013 3 0.694
PTK2BPTK2B 0.689 0.082 -1 0.739
LYNLYN 0.689 0.065 3 0.619
NTRK1NTRK1 0.689 0.049 -1 0.725
FYNFYN 0.689 0.069 -1 0.709
TNK1TNK1 0.688 -0.057 3 0.647
NTRK2NTRK2 0.688 0.040 3 0.690
FGFR3FGFR3 0.686 0.049 3 0.700
PDGFRAPDGFRA 0.686 -0.062 3 0.678
DDR2DDR2 0.685 0.064 3 0.673
INSRINSR 0.685 -0.000 3 0.643
EPHA8EPHA8 0.685 0.056 -1 0.727
FLT4FLT4 0.683 -0.016 3 0.668
CK1G3CK1G3 0.683 -0.005 -3 0.426
ERBB2ERBB2 0.682 -0.038 1 0.650
NEK10_TYRNEK10_TYR 0.682 -0.108 1 0.577
PTK6PTK6 0.681 -0.075 -1 0.681
NTRK3NTRK3 0.681 0.023 -1 0.686
FLT1FLT1 0.680 -0.035 -1 0.712
WEE1_TYRWEE1_TYR 0.680 -0.066 -1 0.689
TNNI3K_TYRTNNI3K_TYR 0.679 -0.132 1 0.683
EPHA2EPHA2 0.678 0.066 -1 0.710
MATKMATK 0.677 -0.024 -1 0.642
EGFREGFR 0.677 0.004 1 0.563
SRCSRC 0.676 0.005 -1 0.711
FGFR4FGFR4 0.675 0.028 -1 0.684
IGF1RIGF1R 0.675 0.010 3 0.593
CSKCSK 0.675 -0.035 2 0.740
PTK2PTK2 0.674 0.028 -1 0.666
SYKSYK 0.670 0.023 -1 0.661
ERBB4ERBB4 0.670 0.024 1 0.594
YANK2YANK2 0.667 -0.067 2 0.384
FESFES 0.664 0.009 -1 0.668
MUSKMUSK 0.660 -0.107 1 0.562
CK1G2CK1G2 0.655 -0.040 -3 0.503
ZAP70ZAP70 0.644 -0.046 -1 0.589