Motif 676 (n=122)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
O00418 | EEF2K | S491 | psp | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
O15126 | SCAMP1 | S112 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
O15372 | EIF3H | S236 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
O43491 | EPB41L2 | S392 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O43524 | FOXO3 | S321 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
O43822 | CFAP410 | S165 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
O60763 | USO1 | S851 | ochoa | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
O60934 | NBN | S278 | psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
O75150 | RNF40 | S853 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
O75665 | OFD1 | S899 | ochoa|psp | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
O75943 | RAD17 | S646 | psp | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
O94818 | NOL4 | S239 | ochoa | Nucleolar protein 4 (Nucleolar-localized protein) | None |
O95235 | KIF20A | S635 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95260 | ATE1 | S169 | ochoa | Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) | Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250|UniProtKB:Q9Z2A5, ECO:0000269|PubMed:34893540}. |
O95490 | ADGRL2 | S1353 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
O95613 | PCNT | S1814 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
P06753 | TPM3 | S62 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
P07951 | TPM2 | S61 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
P09493 | TPM1 | S61 | psp | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
P10645 | CHGA | S126 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
P12882 | MYH1 | S1144 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | S1140 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | S1142 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | S1143 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P23327 | HRC | S221 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
P26232 | CTNNA2 | S654 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
P27105 | STOM | S231 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
P28290 | ITPRID2 | S33 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
P29144 | TPP2 | S1039 | ochoa | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
P33993 | MCM7 | S314 | ochoa | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
P35241 | RDX | S532 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
P35269 | GTF2F1 | S345 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
P35580 | MYH10 | S1145 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
P35749 | MYH11 | S1314 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P35749 | MYH11 | S1770 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P38398 | BRCA1 | S1217 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P43121 | MCAM | S614 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
P46100 | ATRX | S1418 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46939 | UTRN | S784 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P55010 | EIF5 | S229 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
P55081 | MFAP1 | S94 | ochoa | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
P57768 | SNX16 | S298 | ochoa | Sorting nexin-16 | May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}. |
P61278 | SST | S74 | ochoa | Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] | [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}. |
P61981 | YWHAG | S155 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
P78347 | GTF2I | S103 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
Q02224 | CENPE | S611 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
Q03188 | CENPC | S615 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
Q06265 | EXOSC9 | S306 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
Q12929 | EPS8 | S790 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
Q13136 | PPFIA1 | S448 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
Q13796 | SHROOM2 | S1337 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Q14690 | PDCD11 | S1498 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
Q14789 | GOLGB1 | S869 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
Q1MSJ5 | CSPP1 | S77 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
Q5T9A4 | ATAD3B | S120 | ochoa | ATPase family AAA domain-containing protein 3B (AAA-TOB3) | May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. {ECO:0000269|PubMed:22664726}. |
Q5VUB5 | FAM171A1 | S494 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
Q5VZ18 | SHE | S341 | ochoa | SH2 domain-containing adapter protein E | None |
Q5VZ89 | DENND4C | S1802 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q66K14 | TBC1D9B | S547 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
Q6WKZ4 | RAB11FIP1 | S935 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q7Z406 | MYH14 | S1324 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Q86SQ0 | PHLDB2 | S896 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86W56 | PARG | S316 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
Q8N4C6 | NIN | S1193 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
Q8N4N8 | KIF2B | S616 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
Q8NDI1 | EHBP1 | S307 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
Q8NEJ9 | NGDN | S204 | ochoa | Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}. |
Q8WUM9 | SLC20A1 | S288 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
Q8WXW3 | PIBF1 | S703 | ochoa | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) | Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}. |
Q8WYP5 | AHCTF1 | S1847 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
Q92610 | ZNF592 | S1227 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
Q92625 | ANKS1A | S666 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
Q93074 | MED12 | S665 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
Q96EV2 | RBM33 | S233 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
Q9BQF6 | SENP7 | S25 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
Q9BV73 | CEP250 | S1991 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
Q9BVJ6 | UTP14A | S51 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
Q9BVS4 | RIOK2 | S370 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
Q9BVS4 | RIOK2 | S380 | ochoa|psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
Q9BX40 | LSM14B | S323 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
Q9BXL6 | CARD14 | S241 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
Q9BZI7 | UPF3B | S415 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
Q9H0A0 | NAT10 | S934 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
Q9H7D0 | DOCK5 | S1742 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
Q9H8G2 | CAAP1 | S203 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
Q9HAW4 | CLSPN | S958 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
Q9HC44 | GPBP1L1 | S382 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
Q9NRY4 | ARHGAP35 | S1006 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
Q9NRY5 | FAM114A2 | S209 | ochoa | Protein FAM114A2 | None |
Q9NS23 | RASSF1 | S135 | psp | Ras association domain-containing protein 1 | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}. |
Q9NVF7 | FBXO28 | S338 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
Q9NVI7 | ATAD3A | S168 | ochoa | ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}. |
Q9NW68 | BSDC1 | S79 | ochoa | BSD domain-containing protein 1 | None |
Q9P0K7 | RAI14 | S482 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
Q9P219 | CCDC88C | S486 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
Q9P246 | STIM2 | S343 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
Q9UEU0 | VTI1B | S185 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}. |
Q9UJX4 | ANAPC5 | S195 | ochoa | Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
Q9UKI8 | TLK1 | S357 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Q9UKX2 | MYH2 | S1146 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9ULD2 | MTUS1 | S1224 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9UNE0 | EDAR | S273 | ochoa | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
Q9UPV0 | CEP164 | S383 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
Q9UPV7 | PHF24 | S241 | ochoa | PHD finger protein 24 | None |
Q9UQ35 | SRRM2 | S1257 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y426 | C2CD2 | S581 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
Q9Y623 | MYH4 | S1144 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
P33176 | KIF5B | S527 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
Q14444 | CAPRIN1 | S200 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
O43293 | DAPK3 | S371 | Sugiyama | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
P09497 | CLTB | S144 | Sugiyama | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
Q02878 | RPL6 | S255 | Sugiyama | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}. |
Q12906 | ILF3 | S46 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
Q8NE71 | ABCF1 | S285 | Sugiyama | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}. |
Q99816 | TSG101 | S299 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
O95259 | KCNH1 | S952 | Sugiyama | Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25420144, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:25915598, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:30149017, ECO:0000269|PubMed:9738473}. |
P16949 | STMN1 | S94 | Sugiyama | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
O75496 | GMNN | Y111 | Sugiyama | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
Q9UH65 | SWAP70 | S409 | Sugiyama | Switch-associated protein 70 (SWAP-70) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
Q9BQS8 | FYCO1 | S425 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
Q7KZI7 | MARK2 | S704 | Sugiyama | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q9UK32 | RPS6KA6 | S318 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1640170 | Cell Cycle | 0.000001 | 5.914 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.000002 | 5.619 |
R-HSA-390522 | Striated Muscle Contraction | 0.000019 | 4.728 |
R-HSA-68877 | Mitotic Prometaphase | 0.000052 | 4.283 |
R-HSA-68886 | M Phase | 0.000090 | 4.043 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.000186 | 3.730 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.000271 | 3.567 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.000271 | 3.567 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.000280 | 3.552 |
R-HSA-983189 | Kinesins | 0.000223 | 3.652 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.000280 | 3.552 |
R-HSA-69481 | G2/M Checkpoints | 0.000147 | 3.832 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.000118 | 3.930 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.000236 | 3.627 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.000327 | 3.485 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.000338 | 3.471 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.000338 | 3.471 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.000370 | 3.431 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.000492 | 3.308 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.000479 | 3.319 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.000520 | 3.284 |
R-HSA-380287 | Centrosome maturation | 0.000549 | 3.260 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.000750 | 3.125 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.000869 | 3.061 |
R-HSA-9675135 | Diseases of DNA repair | 0.000941 | 3.026 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.001080 | 2.966 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.001097 | 2.960 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.001200 | 2.921 |
R-HSA-445355 | Smooth Muscle Contraction | 0.001469 | 2.833 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.001684 | 2.774 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.001974 | 2.705 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.002374 | 2.625 |
R-HSA-373755 | Semaphorin interactions | 0.002539 | 2.595 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.003086 | 2.511 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.003389 | 2.470 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003528 | 2.453 |
R-HSA-5693538 | Homology Directed Repair | 0.004121 | 2.385 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.004582 | 2.339 |
R-HSA-2132295 | MHC class II antigen presentation | 0.004811 | 2.318 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.004877 | 2.312 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.004995 | 2.301 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.005627 | 2.250 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.006230 | 2.206 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.006614 | 2.180 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.006796 | 2.168 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.006796 | 2.168 |
R-HSA-199991 | Membrane Trafficking | 0.006832 | 2.165 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.007047 | 2.152 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.008100 | 2.092 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.008982 | 2.047 |
R-HSA-397014 | Muscle contraction | 0.010549 | 1.977 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.011819 | 1.927 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.015651 | 1.805 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.015651 | 1.805 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.015651 | 1.805 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015651 | 1.805 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.015651 | 1.805 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.015651 | 1.805 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015651 | 1.805 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.015711 | 1.804 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.016961 | 1.771 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.016961 | 1.771 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.016961 | 1.771 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.016961 | 1.771 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.015087 | 1.821 |
R-HSA-72312 | rRNA processing | 0.015282 | 1.816 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.015884 | 1.799 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.017454 | 1.758 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.019060 | 1.720 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.025295 | 1.597 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.022651 | 1.645 |
R-HSA-5617833 | Cilium Assembly | 0.025539 | 1.593 |
R-HSA-69275 | G2/M Transition | 0.023760 | 1.624 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.024639 | 1.608 |
R-HSA-9675108 | Nervous system development | 0.021470 | 1.668 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.026754 | 1.573 |
R-HSA-5653656 | Vesicle-mediated transport | 0.031248 | 1.505 |
R-HSA-9615710 | Late endosomal microautophagy | 0.031597 | 1.500 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.033259 | 1.478 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.040239 | 1.395 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.036685 | 1.436 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.038446 | 1.415 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.038672 | 1.413 |
R-HSA-68882 | Mitotic Anaphase | 0.039777 | 1.400 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.040381 | 1.394 |
R-HSA-422475 | Axon guidance | 0.035790 | 1.446 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.039290 | 1.406 |
R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.046227 | 1.335 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.048653 | 1.313 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.051632 | 1.287 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.053153 | 1.274 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.053631 | 1.271 |
R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.061159 | 1.214 |
R-HSA-444257 | RSK activation | 0.083125 | 1.080 |
R-HSA-196025 | Formation of annular gap junctions | 0.083125 | 1.080 |
R-HSA-190873 | Gap junction degradation | 0.090332 | 1.044 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.070026 | 1.155 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.088903 | 1.051 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.084261 | 1.074 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.071396 | 1.146 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.084261 | 1.074 |
R-HSA-176974 | Unwinding of DNA | 0.090332 | 1.044 |
R-HSA-912446 | Meiotic recombination | 0.079587 | 1.099 |
R-HSA-437239 | Recycling pathway of L1 | 0.070556 | 1.151 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.072781 | 1.138 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.090332 | 1.044 |
R-HSA-73894 | DNA Repair | 0.081199 | 1.090 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.090332 | 1.044 |
R-HSA-69239 | Synthesis of DNA | 0.068667 | 1.163 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.090332 | 1.044 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.091347 | 1.039 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.091347 | 1.039 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.104580 | 0.981 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.125537 | 0.901 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.146007 | 0.836 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.146007 | 0.836 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.172563 | 0.763 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.172563 | 0.763 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.185532 | 0.732 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.198300 | 0.703 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.204609 | 0.689 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.204609 | 0.689 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.229356 | 0.639 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.229356 | 0.639 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.235423 | 0.628 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.235423 | 0.628 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.235423 | 0.628 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.235423 | 0.628 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.204002 | 0.690 |
R-HSA-72172 | mRNA Splicing | 0.102044 | 0.991 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.166002 | 0.780 |
R-HSA-72086 | mRNA Capping | 0.241442 | 0.617 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.098632 | 1.006 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.118798 | 0.925 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.206869 | 0.684 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.256098 | 0.592 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.191941 | 0.717 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.256098 | 0.592 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.111620 | 0.952 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.265052 | 0.577 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.211316 | 0.675 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.159389 | 0.798 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.244460 | 0.612 |
R-HSA-9614085 | FOXO-mediated transcription | 0.215497 | 0.667 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.223242 | 0.651 |
R-HSA-525793 | Myogenesis | 0.223242 | 0.651 |
R-HSA-9930044 | Nuclear RNA decay | 0.265052 | 0.577 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.097484 | 1.011 |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.125537 | 0.901 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.152725 | 0.816 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.166002 | 0.780 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.172563 | 0.763 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.241442 | 0.617 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.241442 | 0.617 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.253340 | 0.596 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.166002 | 0.780 |
R-HSA-1500620 | Meiosis | 0.167244 | 0.777 |
R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.132414 | 0.878 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.139237 | 0.856 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.146007 | 0.836 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.198300 | 0.703 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.223242 | 0.651 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.253340 | 0.596 |
R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.111620 | 0.952 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.152725 | 0.816 |
R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.172563 | 0.763 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.185532 | 0.732 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.210869 | 0.676 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.247414 | 0.607 |
R-HSA-69306 | DNA Replication | 0.153403 | 0.814 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.210869 | 0.676 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.210869 | 0.676 |
R-HSA-8953854 | Metabolism of RNA | 0.139356 | 0.856 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.111620 | 0.952 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.139237 | 0.856 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.223242 | 0.651 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.229356 | 0.639 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.118606 | 0.926 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.111620 | 0.952 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.125537 | 0.901 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.139237 | 0.856 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.146007 | 0.836 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.229356 | 0.639 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.125537 | 0.901 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.139237 | 0.856 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.146007 | 0.836 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.204609 | 0.689 |
R-HSA-5689901 | Metalloprotease DUBs | 0.223242 | 0.651 |
R-HSA-5669034 | TNFs bind their physiological receptors | 0.210869 | 0.676 |
R-HSA-9659379 | Sensory processing of sound | 0.150708 | 0.822 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.139237 | 0.856 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.235423 | 0.628 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.241442 | 0.617 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.121388 | 0.916 |
R-HSA-69190 | DNA strand elongation | 0.259219 | 0.586 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.241553 | 0.617 |
R-HSA-175474 | Assembly Of The HIV Virion | 0.191941 | 0.717 |
R-HSA-166208 | mTORC1-mediated signalling | 0.198300 | 0.703 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.265052 | 0.577 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.241553 | 0.617 |
R-HSA-69242 | S Phase | 0.144178 | 0.841 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.223242 | 0.651 |
R-HSA-114452 | Activation of BH3-only proteins | 0.247414 | 0.607 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.131880 | 0.880 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.132261 | 0.879 |
R-HSA-373760 | L1CAM interactions | 0.273574 | 0.563 |
R-HSA-381042 | PERK regulates gene expression | 0.282280 | 0.549 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.167244 | 0.777 |
R-HSA-1181150 | Signaling by NODAL | 0.179073 | 0.747 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.223242 | 0.651 |
R-HSA-264876 | Insulin processing | 0.229356 | 0.639 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.204609 | 0.689 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.249143 | 0.604 |
R-HSA-1236394 | Signaling by ERBB4 | 0.137203 | 0.863 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.270840 | 0.567 |
R-HSA-109581 | Apoptosis | 0.170461 | 0.768 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.259219 | 0.586 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.186904 | 0.728 |
R-HSA-5357801 | Programmed Cell Death | 0.262134 | 0.581 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.279145 | 0.554 |
R-HSA-9682385 | FLT3 signaling in disease | 0.287933 | 0.541 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.287933 | 0.541 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 0.287933 | 0.541 |
R-HSA-73886 | Chromosome Maintenance | 0.288128 | 0.540 |
R-HSA-1296072 | Voltage gated Potassium channels | 0.293542 | 0.532 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.299107 | 0.524 |
R-HSA-69206 | G1/S Transition | 0.302652 | 0.519 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.304628 | 0.516 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.310107 | 0.508 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.310107 | 0.508 |
R-HSA-167169 | HIV Transcription Elongation | 0.310107 | 0.508 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.310107 | 0.508 |
R-HSA-9646399 | Aggrephagy | 0.310107 | 0.508 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.310107 | 0.508 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.315542 | 0.501 |
R-HSA-9607240 | FLT3 Signaling | 0.315542 | 0.501 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.315542 | 0.501 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.315542 | 0.501 |
R-HSA-1474165 | Reproduction | 0.320013 | 0.495 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.320935 | 0.494 |
R-HSA-167161 | HIV Transcription Initiation | 0.320935 | 0.494 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.320935 | 0.494 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.320935 | 0.494 |
R-HSA-165159 | MTOR signalling | 0.326286 | 0.486 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.331595 | 0.479 |
R-HSA-190828 | Gap junction trafficking | 0.336863 | 0.473 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.342089 | 0.466 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.342089 | 0.466 |
R-HSA-774815 | Nucleosome assembly | 0.342089 | 0.466 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.347275 | 0.459 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.347275 | 0.459 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.347275 | 0.459 |
R-HSA-75153 | Apoptotic execution phase | 0.347275 | 0.459 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.352420 | 0.453 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.352420 | 0.453 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.352420 | 0.453 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.360078 | 0.444 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.362589 | 0.441 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.367614 | 0.435 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.371377 | 0.430 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.374189 | 0.427 |
R-HSA-72187 | mRNA 3'-end processing | 0.377547 | 0.423 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.377547 | 0.423 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.377547 | 0.423 |
R-HSA-68949 | Orc1 removal from chromatin | 0.377547 | 0.423 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.377547 | 0.423 |
R-HSA-6794361 | Neurexins and neuroligins | 0.377547 | 0.423 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.382455 | 0.417 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.382455 | 0.417 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.382455 | 0.417 |
R-HSA-1221632 | Meiotic synapsis | 0.382455 | 0.417 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.382455 | 0.417 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.382597 | 0.417 |
R-HSA-72649 | Translation initiation complex formation | 0.387325 | 0.412 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.387325 | 0.412 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.388175 | 0.411 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.392157 | 0.407 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.396502 | 0.402 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.396951 | 0.401 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.396951 | 0.401 |
R-HSA-9612973 | Autophagy | 0.399266 | 0.399 |
R-HSA-162587 | HIV Life Cycle | 0.402025 | 0.396 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.406426 | 0.391 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.411108 | 0.386 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.420363 | 0.376 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.420363 | 0.376 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.424936 | 0.372 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.424936 | 0.372 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.429474 | 0.367 |
R-HSA-8848021 | Signaling by PTK6 | 0.429474 | 0.367 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.438442 | 0.358 |
R-HSA-162582 | Signal Transduction | 0.449905 | 0.347 |
R-HSA-109582 | Hemostasis | 0.450949 | 0.346 |
R-HSA-167172 | Transcription of the HIV genome | 0.451633 | 0.345 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.460256 | 0.337 |
R-HSA-168255 | Influenza Infection | 0.463705 | 0.334 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.464516 | 0.333 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.464516 | 0.333 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.464516 | 0.333 |
R-HSA-2559583 | Cellular Senescence | 0.466304 | 0.331 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.468744 | 0.329 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.468744 | 0.329 |
R-HSA-212436 | Generic Transcription Pathway | 0.472677 | 0.325 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.472938 | 0.325 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.472938 | 0.325 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.477099 | 0.321 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.477099 | 0.321 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.481228 | 0.318 |
R-HSA-8852135 | Protein ubiquitination | 0.481228 | 0.318 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.487755 | 0.312 |
R-HSA-1266738 | Developmental Biology | 0.488551 | 0.311 |
R-HSA-4086400 | PCP/CE pathway | 0.493422 | 0.307 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.496903 | 0.304 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.501392 | 0.300 |
R-HSA-5654738 | Signaling by FGFR2 | 0.501392 | 0.300 |
R-HSA-9833482 | PKR-mediated signaling | 0.501392 | 0.300 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.509238 | 0.293 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.509238 | 0.293 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.513115 | 0.290 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.520778 | 0.283 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.520778 | 0.283 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.521546 | 0.283 |
R-HSA-376176 | Signaling by ROBO receptors | 0.523966 | 0.281 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.524565 | 0.280 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.524565 | 0.280 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.528322 | 0.277 |
R-HSA-438064 | Post NMDA receptor activation events | 0.532049 | 0.274 |
R-HSA-156902 | Peptide chain elongation | 0.535747 | 0.271 |
R-HSA-9663891 | Selective autophagy | 0.535747 | 0.271 |
R-HSA-9645723 | Diseases of programmed cell death | 0.535747 | 0.271 |
R-HSA-112316 | Neuronal System | 0.540699 | 0.267 |
R-HSA-112310 | Neurotransmitter release cycle | 0.543057 | 0.265 |
R-HSA-73884 | Base Excision Repair | 0.543057 | 0.265 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.546669 | 0.262 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.550252 | 0.259 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.553808 | 0.257 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.564307 | 0.248 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.567753 | 0.246 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.567753 | 0.246 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.571171 | 0.243 |
R-HSA-1296071 | Potassium Channels | 0.571171 | 0.243 |
R-HSA-157579 | Telomere Maintenance | 0.574562 | 0.241 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.574562 | 0.241 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.577927 | 0.238 |
R-HSA-190236 | Signaling by FGFR | 0.577927 | 0.238 |
R-HSA-162906 | HIV Infection | 0.581777 | 0.235 |
R-HSA-5610787 | Hedgehog 'off' state | 0.584577 | 0.233 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.584577 | 0.233 |
R-HSA-2408557 | Selenocysteine synthesis | 0.587863 | 0.231 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.587863 | 0.231 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.591123 | 0.228 |
R-HSA-192823 | Viral mRNA Translation | 0.594358 | 0.226 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.597568 | 0.224 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.597568 | 0.224 |
R-HSA-9833110 | RSV-host interactions | 0.600752 | 0.221 |
R-HSA-8939211 | ESR-mediated signaling | 0.603429 | 0.219 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.607045 | 0.217 |
R-HSA-1280218 | Adaptive Immune System | 0.609744 | 0.215 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.610155 | 0.215 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.613240 | 0.212 |
R-HSA-2672351 | Stimuli-sensing channels | 0.613240 | 0.212 |
R-HSA-6803157 | Antimicrobial peptides | 0.622352 | 0.206 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.634170 | 0.198 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.637066 | 0.196 |
R-HSA-5688426 | Deubiquitination | 0.640267 | 0.194 |
R-HSA-9007101 | Rab regulation of trafficking | 0.645620 | 0.190 |
R-HSA-2980736 | Peptide hormone metabolism | 0.645620 | 0.190 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.648427 | 0.188 |
R-HSA-68875 | Mitotic Prophase | 0.653975 | 0.184 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.670101 | 0.174 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.670101 | 0.174 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.670101 | 0.174 |
R-HSA-114608 | Platelet degranulation | 0.675309 | 0.170 |
R-HSA-9843745 | Adipogenesis | 0.687975 | 0.162 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.690449 | 0.161 |
R-HSA-72766 | Translation | 0.692099 | 0.160 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.692903 | 0.159 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.702529 | 0.153 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.702529 | 0.153 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.704888 | 0.152 |
R-HSA-9948299 | Ribosome-associated quality control | 0.707229 | 0.150 |
R-HSA-5358351 | Signaling by Hedgehog | 0.707229 | 0.150 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.709551 | 0.149 |
R-HSA-9664407 | Parasite infection | 0.711855 | 0.148 |
R-HSA-9664417 | Leishmania phagocytosis | 0.711855 | 0.148 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.711855 | 0.148 |
R-HSA-1632852 | Macroautophagy | 0.714141 | 0.146 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.714141 | 0.146 |
R-HSA-74160 | Gene expression (Transcription) | 0.715341 | 0.145 |
R-HSA-195721 | Signaling by WNT | 0.717403 | 0.144 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.720891 | 0.142 |
R-HSA-6798695 | Neutrophil degranulation | 0.730562 | 0.136 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.738128 | 0.132 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.744316 | 0.128 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.744316 | 0.128 |
R-HSA-1989781 | PPARA activates gene expression | 0.746347 | 0.127 |
R-HSA-9610379 | HCMV Late Events | 0.750359 | 0.125 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.750359 | 0.125 |
R-HSA-9711097 | Cellular response to starvation | 0.752342 | 0.124 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.755585 | 0.122 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.763914 | 0.117 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.780273 | 0.108 |
R-HSA-5689880 | Ub-specific processing proteases | 0.782020 | 0.107 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.783753 | 0.106 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.785472 | 0.105 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.798748 | 0.098 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.803513 | 0.095 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.807478 | 0.093 |
R-HSA-983712 | Ion channel transport | 0.808166 | 0.092 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.818603 | 0.087 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.824312 | 0.084 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.830633 | 0.081 |
R-HSA-2262752 | Cellular responses to stress | 0.834903 | 0.078 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.841663 | 0.075 |
R-HSA-418990 | Adherens junctions interactions | 0.849087 | 0.071 |
R-HSA-8951664 | Neddylation | 0.852668 | 0.069 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.860700 | 0.065 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.867122 | 0.062 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.880382 | 0.055 |
R-HSA-9609646 | HCMV Infection | 0.883221 | 0.054 |
R-HSA-421270 | Cell-cell junction organization | 0.884154 | 0.053 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.888709 | 0.051 |
R-HSA-9734767 | Developmental Cell Lineages | 0.894789 | 0.048 |
R-HSA-9711123 | Cellular response to chemical stress | 0.898929 | 0.046 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.903685 | 0.044 |
R-HSA-8953897 | Cellular responses to stimuli | 0.904274 | 0.044 |
R-HSA-168256 | Immune System | 0.905980 | 0.043 |
R-HSA-446728 | Cell junction organization | 0.906731 | 0.043 |
R-HSA-9658195 | Leishmania infection | 0.908952 | 0.041 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.908952 | 0.041 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.918646 | 0.037 |
R-HSA-1643685 | Disease | 0.922903 | 0.035 |
R-HSA-1500931 | Cell-Cell communication | 0.931298 | 0.031 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.935065 | 0.029 |
R-HSA-1474244 | Extracellular matrix organization | 0.939120 | 0.027 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.944289 | 0.025 |
R-HSA-5683057 | MAPK family signaling cascades | 0.946492 | 0.024 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.947349 | 0.023 |
R-HSA-9824446 | Viral Infection Pathways | 0.952716 | 0.021 |
R-HSA-913531 | Interferon Signaling | 0.960319 | 0.018 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.963699 | 0.016 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.964570 | 0.016 |
R-HSA-449147 | Signaling by Interleukins | 0.965197 | 0.015 |
R-HSA-418594 | G alpha (i) signalling events | 0.967326 | 0.014 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.976192 | 0.010 |
R-HSA-168249 | Innate Immune System | 0.984303 | 0.007 |
R-HSA-382551 | Transport of small molecules | 0.987223 | 0.006 |
R-HSA-9679506 | SARS-CoV Infections | 0.990206 | 0.004 |
R-HSA-500792 | GPCR ligand binding | 0.992586 | 0.003 |
R-HSA-597592 | Post-translational protein modification | 0.993297 | 0.003 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994156 | 0.003 |
R-HSA-5663205 | Infectious disease | 0.994431 | 0.002 |
R-HSA-392499 | Metabolism of proteins | 0.995072 | 0.002 |
R-HSA-388396 | GPCR downstream signalling | 0.998388 | 0.001 |
R-HSA-372790 | Signaling by GPCR | 0.999192 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999616 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999996 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.797 | 0.137 | 2 | 0.818 |
CDC7 |
0.794 | 0.115 | 1 | 0.848 |
FAM20C |
0.793 | 0.235 | 2 | 0.765 |
ATM |
0.788 | 0.206 | 1 | 0.787 |
SKMLCK |
0.786 | 0.186 | -2 | 0.814 |
RSK2 |
0.784 | 0.094 | -3 | 0.737 |
DSTYK |
0.783 | 0.073 | 2 | 0.848 |
MOS |
0.783 | 0.067 | 1 | 0.830 |
GCN2 |
0.783 | -0.051 | 2 | 0.762 |
TGFBR2 |
0.783 | 0.076 | -2 | 0.807 |
PRKD2 |
0.783 | 0.076 | -3 | 0.738 |
PIM3 |
0.783 | 0.037 | -3 | 0.769 |
CAMK1B |
0.782 | 0.056 | -3 | 0.804 |
PRKD1 |
0.781 | 0.045 | -3 | 0.749 |
NDR2 |
0.781 | 0.023 | -3 | 0.762 |
ATR |
0.780 | 0.103 | 1 | 0.797 |
RIPK3 |
0.780 | 0.123 | 3 | 0.691 |
RAF1 |
0.779 | -0.009 | 1 | 0.739 |
PRPK |
0.779 | -0.041 | -1 | 0.744 |
NDR1 |
0.779 | 0.038 | -3 | 0.771 |
CAMLCK |
0.778 | 0.118 | -2 | 0.830 |
CLK3 |
0.778 | 0.052 | 1 | 0.680 |
P90RSK |
0.778 | 0.063 | -3 | 0.738 |
BMPR2 |
0.777 | 0.066 | -2 | 0.842 |
PIM1 |
0.777 | 0.079 | -3 | 0.753 |
MAPKAPK2 |
0.777 | 0.068 | -3 | 0.699 |
CAMK2G |
0.776 | 0.037 | 2 | 0.804 |
PKN3 |
0.776 | 0.019 | -3 | 0.762 |
MAPKAPK3 |
0.776 | 0.042 | -3 | 0.720 |
ULK2 |
0.776 | -0.103 | 2 | 0.757 |
TSSK2 |
0.776 | 0.043 | -5 | 0.810 |
DAPK2 |
0.775 | 0.112 | -3 | 0.790 |
CAMK2B |
0.775 | 0.115 | 2 | 0.798 |
BMPR1B |
0.775 | 0.150 | 1 | 0.772 |
LATS2 |
0.775 | 0.038 | -5 | 0.747 |
GRK6 |
0.774 | 0.081 | 1 | 0.758 |
NEK7 |
0.774 | -0.013 | -3 | 0.729 |
TBK1 |
0.774 | -0.054 | 1 | 0.605 |
RSK3 |
0.773 | 0.051 | -3 | 0.727 |
CDKL1 |
0.773 | 0.027 | -3 | 0.750 |
NEK6 |
0.772 | -0.034 | -2 | 0.840 |
IKKB |
0.772 | -0.048 | -2 | 0.678 |
MSK2 |
0.772 | 0.067 | -3 | 0.698 |
P70S6KB |
0.772 | 0.054 | -3 | 0.754 |
NIM1 |
0.772 | 0.010 | 3 | 0.659 |
WNK1 |
0.771 | -0.007 | -2 | 0.787 |
NUAK2 |
0.771 | -0.001 | -3 | 0.794 |
WNK3 |
0.771 | -0.031 | 1 | 0.717 |
PRKD3 |
0.771 | 0.061 | -3 | 0.721 |
AMPKA1 |
0.771 | -0.009 | -3 | 0.786 |
PKACG |
0.771 | 0.052 | -2 | 0.753 |
NLK |
0.770 | -0.017 | 1 | 0.640 |
MARK4 |
0.770 | -0.038 | 4 | 0.611 |
NIK |
0.770 | -0.007 | -3 | 0.800 |
PAK6 |
0.770 | 0.102 | -2 | 0.710 |
PDHK4 |
0.770 | -0.156 | 1 | 0.736 |
IKKE |
0.770 | -0.068 | 1 | 0.598 |
CAMK4 |
0.770 | 0.032 | -3 | 0.771 |
MYLK4 |
0.770 | 0.112 | -2 | 0.773 |
TSSK1 |
0.770 | 0.008 | -3 | 0.794 |
AURC |
0.770 | 0.069 | -2 | 0.695 |
ACVR2A |
0.770 | 0.149 | -2 | 0.801 |
PKCD |
0.769 | 0.012 | 2 | 0.744 |
ACVR2B |
0.769 | 0.161 | -2 | 0.806 |
CAMK2D |
0.769 | 0.024 | -3 | 0.756 |
AURB |
0.768 | 0.089 | -2 | 0.694 |
HUNK |
0.768 | -0.082 | 2 | 0.758 |
PKACB |
0.768 | 0.097 | -2 | 0.716 |
MSK1 |
0.768 | 0.096 | -3 | 0.699 |
ALK2 |
0.768 | 0.155 | -2 | 0.761 |
PAK1 |
0.767 | 0.054 | -2 | 0.771 |
PLK1 |
0.767 | 0.079 | -2 | 0.846 |
MLK1 |
0.767 | -0.032 | 2 | 0.760 |
AMPKA2 |
0.767 | -0.003 | -3 | 0.768 |
GRK4 |
0.767 | 0.012 | -2 | 0.768 |
PAK3 |
0.767 | 0.038 | -2 | 0.773 |
MNK2 |
0.767 | 0.038 | -2 | 0.790 |
RSK4 |
0.767 | 0.078 | -3 | 0.716 |
SMG1 |
0.767 | 0.178 | 1 | 0.777 |
ULK1 |
0.767 | -0.103 | -3 | 0.724 |
MELK |
0.766 | 0.020 | -3 | 0.752 |
SRPK1 |
0.766 | 0.022 | -3 | 0.719 |
NUAK1 |
0.766 | 0.001 | -3 | 0.753 |
PKN2 |
0.766 | -0.016 | -3 | 0.778 |
GRK5 |
0.766 | -0.053 | -3 | 0.751 |
TGFBR1 |
0.766 | 0.082 | -2 | 0.751 |
NEK9 |
0.766 | -0.039 | 2 | 0.783 |
MST4 |
0.765 | -0.032 | 2 | 0.753 |
BMPR1A |
0.765 | 0.149 | 1 | 0.773 |
GRK1 |
0.765 | 0.048 | -2 | 0.698 |
SIK |
0.765 | 0.014 | -3 | 0.726 |
LATS1 |
0.764 | 0.077 | -3 | 0.756 |
CDKL5 |
0.764 | -0.003 | -3 | 0.741 |
SRPK2 |
0.764 | 0.031 | -3 | 0.660 |
IRE2 |
0.764 | -0.016 | 2 | 0.714 |
ERK5 |
0.764 | -0.024 | 1 | 0.598 |
PRKX |
0.763 | 0.104 | -3 | 0.675 |
AURA |
0.763 | 0.081 | -2 | 0.675 |
DNAPK |
0.763 | 0.126 | 1 | 0.688 |
CAMK2A |
0.763 | 0.043 | 2 | 0.781 |
ALK4 |
0.763 | 0.057 | -2 | 0.775 |
PKG2 |
0.762 | 0.071 | -2 | 0.713 |
BCKDK |
0.762 | -0.106 | -1 | 0.703 |
PDHK1 |
0.762 | -0.203 | 1 | 0.711 |
HIPK4 |
0.762 | -0.031 | 1 | 0.646 |
MTOR |
0.762 | -0.182 | 1 | 0.641 |
IKKA |
0.761 | -0.032 | -2 | 0.667 |
PLK3 |
0.761 | 0.049 | 2 | 0.745 |
PAK2 |
0.761 | 0.044 | -2 | 0.754 |
MNK1 |
0.760 | 0.040 | -2 | 0.807 |
RIPK1 |
0.760 | -0.072 | 1 | 0.723 |
ANKRD3 |
0.760 | -0.035 | 1 | 0.729 |
TTBK2 |
0.760 | -0.072 | 2 | 0.677 |
IRE1 |
0.759 | -0.087 | 1 | 0.719 |
QSK |
0.759 | -0.026 | 4 | 0.590 |
KIS |
0.759 | -0.018 | 1 | 0.484 |
CHK1 |
0.759 | 0.011 | -3 | 0.748 |
SRPK3 |
0.759 | 0.020 | -3 | 0.695 |
QIK |
0.759 | -0.055 | -3 | 0.756 |
PKACA |
0.758 | 0.096 | -2 | 0.679 |
ICK |
0.758 | -0.019 | -3 | 0.774 |
BRSK1 |
0.758 | -0.018 | -3 | 0.741 |
CHAK2 |
0.758 | -0.090 | -1 | 0.714 |
PIM2 |
0.758 | 0.052 | -3 | 0.720 |
PKCB |
0.757 | -0.016 | 2 | 0.695 |
CLK4 |
0.757 | 0.051 | -3 | 0.752 |
PKR |
0.757 | -0.007 | 1 | 0.749 |
MARK2 |
0.757 | -0.026 | 4 | 0.521 |
AKT2 |
0.757 | 0.059 | -3 | 0.683 |
MLK3 |
0.757 | -0.033 | 2 | 0.697 |
PHKG1 |
0.756 | -0.047 | -3 | 0.766 |
MLK4 |
0.756 | -0.009 | 2 | 0.703 |
DAPK3 |
0.756 | 0.143 | -3 | 0.763 |
MASTL |
0.755 | -0.155 | -2 | 0.743 |
MLK2 |
0.755 | -0.119 | 2 | 0.781 |
DLK |
0.755 | -0.120 | 1 | 0.722 |
MAPKAPK5 |
0.755 | -0.004 | -3 | 0.663 |
CLK1 |
0.755 | 0.041 | -3 | 0.739 |
CAMK1D |
0.755 | 0.070 | -3 | 0.668 |
SNRK |
0.754 | -0.070 | 2 | 0.656 |
SGK3 |
0.754 | 0.046 | -3 | 0.710 |
SMMLCK |
0.754 | 0.096 | -3 | 0.764 |
PKCG |
0.754 | -0.032 | 2 | 0.680 |
PKCH |
0.753 | -0.027 | 2 | 0.684 |
MEK1 |
0.753 | -0.028 | 2 | 0.791 |
CK2A2 |
0.753 | 0.101 | 1 | 0.730 |
PKCA |
0.752 | -0.032 | 2 | 0.682 |
BRAF |
0.752 | 0.019 | -4 | 0.791 |
DCAMKL1 |
0.752 | 0.015 | -3 | 0.753 |
CAMK1G |
0.752 | 0.006 | -3 | 0.735 |
NEK2 |
0.752 | -0.072 | 2 | 0.754 |
MARK1 |
0.752 | -0.038 | 4 | 0.571 |
PAK5 |
0.751 | 0.066 | -2 | 0.657 |
AKT1 |
0.751 | 0.065 | -3 | 0.691 |
SSTK |
0.751 | -0.021 | 4 | 0.583 |
PERK |
0.751 | -0.018 | -2 | 0.812 |
HRI |
0.751 | -0.043 | -2 | 0.838 |
MARK3 |
0.751 | -0.050 | 4 | 0.549 |
PAK4 |
0.750 | 0.076 | -2 | 0.669 |
PLK4 |
0.750 | -0.033 | 2 | 0.604 |
BRSK2 |
0.750 | -0.076 | -3 | 0.752 |
DYRK2 |
0.750 | -0.022 | 1 | 0.520 |
GRK7 |
0.750 | 0.011 | 1 | 0.675 |
PHKG2 |
0.750 | -0.024 | -3 | 0.770 |
TLK2 |
0.749 | -0.048 | 1 | 0.745 |
IRAK4 |
0.748 | -0.043 | 1 | 0.722 |
PKCZ |
0.748 | -0.063 | 2 | 0.732 |
DRAK1 |
0.748 | -0.026 | 1 | 0.680 |
CLK2 |
0.748 | 0.059 | -3 | 0.733 |
TLK1 |
0.748 | -0.035 | -2 | 0.808 |
CHAK1 |
0.747 | -0.115 | 2 | 0.718 |
P70S6K |
0.747 | 0.024 | -3 | 0.676 |
PKCT |
0.747 | -0.018 | 2 | 0.698 |
YSK4 |
0.746 | -0.108 | 1 | 0.665 |
GRK2 |
0.746 | -0.011 | -2 | 0.650 |
WNK4 |
0.745 | -0.067 | -2 | 0.765 |
DAPK1 |
0.745 | 0.102 | -3 | 0.752 |
CK1E |
0.744 | 0.021 | -3 | 0.586 |
MEKK2 |
0.744 | -0.024 | 2 | 0.770 |
DCAMKL2 |
0.744 | -0.008 | -3 | 0.778 |
CDK8 |
0.744 | -0.080 | 1 | 0.461 |
VRK2 |
0.743 | -0.188 | 1 | 0.749 |
CAMK1A |
0.743 | 0.054 | -3 | 0.663 |
NEK5 |
0.743 | -0.016 | 1 | 0.733 |
MEKK3 |
0.743 | -0.048 | 1 | 0.685 |
CDK7 |
0.742 | -0.078 | 1 | 0.475 |
HIPK1 |
0.742 | -0.005 | 1 | 0.529 |
DYRK1A |
0.741 | -0.004 | 1 | 0.547 |
IRAK1 |
0.741 | -0.091 | -1 | 0.681 |
CK2A1 |
0.741 | 0.073 | 1 | 0.710 |
MEKK1 |
0.741 | -0.084 | 1 | 0.693 |
AKT3 |
0.740 | 0.058 | -3 | 0.628 |
MEK5 |
0.739 | -0.143 | 2 | 0.780 |
CDK18 |
0.739 | -0.032 | 1 | 0.398 |
CHK2 |
0.739 | 0.044 | -3 | 0.648 |
DYRK3 |
0.739 | 0.025 | 1 | 0.544 |
ZAK |
0.738 | -0.113 | 1 | 0.661 |
MRCKB |
0.738 | 0.075 | -3 | 0.713 |
NEK8 |
0.738 | -0.053 | 2 | 0.760 |
PKG1 |
0.738 | 0.063 | -2 | 0.653 |
PKN1 |
0.737 | 0.002 | -3 | 0.697 |
CDK19 |
0.737 | -0.081 | 1 | 0.420 |
PLK2 |
0.737 | 0.047 | -3 | 0.738 |
HIPK2 |
0.736 | -0.028 | 1 | 0.431 |
TTK |
0.736 | 0.190 | -2 | 0.843 |
SGK1 |
0.736 | 0.066 | -3 | 0.611 |
TTBK1 |
0.736 | -0.084 | 2 | 0.593 |
JNK2 |
0.736 | -0.031 | 1 | 0.401 |
P38A |
0.735 | -0.061 | 1 | 0.481 |
HIPK3 |
0.735 | -0.033 | 1 | 0.515 |
ROCK2 |
0.735 | 0.074 | -3 | 0.742 |
MRCKA |
0.735 | 0.064 | -3 | 0.721 |
PASK |
0.735 | -0.023 | -3 | 0.774 |
CDK5 |
0.734 | -0.085 | 1 | 0.497 |
PRP4 |
0.734 | -0.046 | -3 | 0.665 |
PINK1 |
0.734 | -0.144 | 1 | 0.675 |
JNK3 |
0.733 | -0.051 | 1 | 0.445 |
PKCI |
0.733 | -0.049 | 2 | 0.689 |
DYRK4 |
0.733 | -0.012 | 1 | 0.434 |
CDK14 |
0.733 | -0.014 | 1 | 0.434 |
SBK |
0.733 | 0.050 | -3 | 0.593 |
CDK17 |
0.733 | -0.049 | 1 | 0.345 |
GRK3 |
0.733 | -0.017 | -2 | 0.603 |
MST3 |
0.733 | -0.065 | 2 | 0.747 |
CAMKK1 |
0.733 | -0.092 | -2 | 0.704 |
DYRK1B |
0.733 | -0.023 | 1 | 0.462 |
CK1D |
0.733 | 0.022 | -3 | 0.538 |
ERK2 |
0.732 | -0.064 | 1 | 0.458 |
CDK16 |
0.732 | -0.014 | 1 | 0.367 |
CK1A2 |
0.732 | 0.020 | -3 | 0.545 |
PKCE |
0.732 | -0.009 | 2 | 0.663 |
TAO3 |
0.731 | -0.084 | 1 | 0.674 |
TAO2 |
0.731 | -0.077 | 2 | 0.794 |
CK1G1 |
0.731 | -0.021 | -3 | 0.568 |
NEK4 |
0.730 | -0.065 | 1 | 0.686 |
DMPK1 |
0.730 | 0.090 | -3 | 0.747 |
CDK13 |
0.729 | -0.105 | 1 | 0.445 |
P38B |
0.728 | -0.053 | 1 | 0.404 |
GAK |
0.728 | -0.038 | 1 | 0.702 |
ERK1 |
0.727 | -0.065 | 1 | 0.394 |
ROCK1 |
0.727 | 0.075 | -3 | 0.724 |
CDK2 |
0.727 | -0.111 | 1 | 0.509 |
GSK3B |
0.726 | -0.083 | 4 | 0.257 |
P38G |
0.726 | -0.061 | 1 | 0.335 |
MPSK1 |
0.725 | -0.101 | 1 | 0.653 |
LKB1 |
0.725 | -0.123 | -3 | 0.712 |
CDK1 |
0.724 | -0.094 | 1 | 0.430 |
NEK1 |
0.724 | -0.055 | 1 | 0.702 |
NEK11 |
0.724 | -0.149 | 1 | 0.649 |
BUB1 |
0.724 | 0.003 | -5 | 0.754 |
TAK1 |
0.724 | -0.042 | 1 | 0.721 |
CDK9 |
0.724 | -0.112 | 1 | 0.448 |
MEKK6 |
0.723 | -0.119 | 1 | 0.681 |
CAMKK2 |
0.723 | -0.140 | -2 | 0.701 |
RIPK2 |
0.723 | -0.112 | 1 | 0.624 |
PDK1 |
0.723 | -0.090 | 1 | 0.654 |
TNIK |
0.723 | -0.067 | 3 | 0.630 |
GSK3A |
0.722 | -0.079 | 4 | 0.273 |
EEF2K |
0.722 | -0.092 | 3 | 0.582 |
CDK12 |
0.722 | -0.104 | 1 | 0.414 |
LOK |
0.722 | -0.071 | -2 | 0.748 |
MST2 |
0.721 | -0.094 | 1 | 0.692 |
CRIK |
0.721 | 0.057 | -3 | 0.681 |
VRK1 |
0.721 | -0.101 | 2 | 0.784 |
ERK7 |
0.720 | -0.036 | 2 | 0.498 |
HGK |
0.720 | -0.115 | 3 | 0.630 |
MEK2 |
0.720 | -0.098 | 2 | 0.773 |
MINK |
0.719 | -0.107 | 1 | 0.664 |
MAP3K15 |
0.718 | -0.141 | 1 | 0.642 |
MOK |
0.718 | -0.002 | 1 | 0.559 |
GCK |
0.718 | -0.104 | 1 | 0.665 |
P38D |
0.718 | -0.050 | 1 | 0.383 |
CDK3 |
0.718 | -0.076 | 1 | 0.365 |
CDK10 |
0.716 | -0.071 | 1 | 0.421 |
PDHK3_TYR |
0.716 | 0.109 | 4 | 0.701 |
LRRK2 |
0.715 | -0.169 | 2 | 0.783 |
EPHA6 |
0.715 | 0.131 | -1 | 0.761 |
YSK1 |
0.714 | -0.113 | 2 | 0.748 |
MAK |
0.714 | -0.006 | -2 | 0.668 |
HPK1 |
0.713 | -0.098 | 1 | 0.642 |
ALPHAK3 |
0.712 | 0.046 | -1 | 0.662 |
KHS1 |
0.712 | -0.090 | 1 | 0.646 |
EPHB4 |
0.711 | 0.150 | -1 | 0.778 |
STK33 |
0.711 | -0.136 | 2 | 0.566 |
NEK3 |
0.711 | -0.141 | 1 | 0.643 |
MST1 |
0.711 | -0.137 | 1 | 0.671 |
PBK |
0.710 | -0.076 | 1 | 0.627 |
SLK |
0.710 | -0.109 | -2 | 0.679 |
TXK |
0.709 | 0.178 | 1 | 0.771 |
KHS2 |
0.709 | -0.077 | 1 | 0.650 |
JNK1 |
0.709 | -0.065 | 1 | 0.397 |
CDK4 |
0.709 | -0.085 | 1 | 0.405 |
BIKE |
0.709 | -0.011 | 1 | 0.572 |
MERTK |
0.708 | 0.232 | 3 | 0.712 |
HASPIN |
0.708 | -0.051 | -1 | 0.568 |
TNK2 |
0.708 | 0.166 | 3 | 0.729 |
FER |
0.707 | 0.123 | 1 | 0.795 |
ABL2 |
0.707 | 0.094 | -1 | 0.732 |
TESK1_TYR |
0.707 | -0.087 | 3 | 0.679 |
SRMS |
0.707 | 0.192 | 1 | 0.785 |
TYRO3 |
0.706 | 0.078 | 3 | 0.660 |
AXL |
0.706 | 0.194 | 3 | 0.728 |
INSRR |
0.706 | 0.121 | 3 | 0.662 |
PDHK4_TYR |
0.705 | 0.006 | 2 | 0.822 |
MAP2K6_TYR |
0.705 | -0.009 | -1 | 0.750 |
EPHB2 |
0.704 | 0.139 | -1 | 0.768 |
EPHB3 |
0.704 | 0.135 | -1 | 0.774 |
BLK |
0.704 | 0.182 | -1 | 0.746 |
MAP2K4_TYR |
0.704 | -0.065 | -1 | 0.763 |
YES1 |
0.704 | 0.103 | -1 | 0.755 |
OSR1 |
0.704 | -0.099 | 2 | 0.738 |
CDK6 |
0.703 | -0.103 | 1 | 0.413 |
PINK1_TYR |
0.703 | -0.082 | 1 | 0.731 |
ROS1 |
0.703 | 0.043 | 3 | 0.657 |
EPHB1 |
0.703 | 0.123 | 1 | 0.770 |
MYO3B |
0.703 | -0.085 | 2 | 0.756 |
RET |
0.703 | -0.012 | 1 | 0.687 |
TEC |
0.703 | 0.148 | -1 | 0.741 |
EPHA4 |
0.702 | 0.103 | 2 | 0.730 |
LCK |
0.702 | 0.114 | -1 | 0.746 |
CSF1R |
0.702 | 0.076 | 3 | 0.699 |
MAP2K7_TYR |
0.702 | -0.156 | 2 | 0.817 |
YANK3 |
0.701 | -0.048 | 2 | 0.358 |
EPHA1 |
0.701 | 0.166 | 3 | 0.713 |
MYO3A |
0.701 | -0.081 | 1 | 0.679 |
ABL1 |
0.701 | 0.052 | -1 | 0.730 |
PDHK1_TYR |
0.700 | -0.047 | -1 | 0.760 |
TYK2 |
0.700 | -0.031 | 1 | 0.684 |
HCK |
0.700 | 0.101 | -1 | 0.760 |
MST1R |
0.700 | 0.013 | 3 | 0.704 |
TAO1 |
0.700 | -0.104 | 1 | 0.613 |
LIMK2_TYR |
0.700 | -0.079 | -3 | 0.779 |
ASK1 |
0.699 | -0.117 | 1 | 0.633 |
EPHA7 |
0.699 | 0.130 | 2 | 0.739 |
BMPR2_TYR |
0.698 | -0.063 | -1 | 0.740 |
EPHA5 |
0.698 | 0.157 | 2 | 0.740 |
JAK3 |
0.698 | 0.004 | 1 | 0.685 |
PKMYT1_TYR |
0.697 | -0.163 | 3 | 0.677 |
DDR1 |
0.697 | -0.004 | 4 | 0.615 |
LTK |
0.697 | 0.065 | 3 | 0.644 |
JAK2 |
0.696 | -0.024 | 1 | 0.664 |
FGFR2 |
0.696 | 0.057 | 3 | 0.706 |
FLT3 |
0.696 | 0.011 | 3 | 0.660 |
ITK |
0.695 | 0.046 | -1 | 0.754 |
BMX |
0.695 | 0.085 | -1 | 0.704 |
KDR |
0.695 | 0.061 | 3 | 0.700 |
PDGFRB |
0.695 | 0.001 | 3 | 0.689 |
TEK |
0.694 | 0.052 | 3 | 0.648 |
LIMK1_TYR |
0.694 | -0.179 | 2 | 0.814 |
ALK |
0.693 | 0.026 | 3 | 0.624 |
KIT |
0.693 | 0.025 | 3 | 0.696 |
EPHA3 |
0.692 | 0.051 | 2 | 0.717 |
AAK1 |
0.692 | -0.002 | 1 | 0.463 |
BTK |
0.692 | 0.046 | -1 | 0.759 |
CK1A |
0.691 | -0.024 | -3 | 0.467 |
STLK3 |
0.691 | -0.113 | 1 | 0.643 |
FGR |
0.691 | -0.058 | 1 | 0.728 |
FRK |
0.691 | 0.071 | -1 | 0.791 |
JAK1 |
0.690 | 0.034 | 1 | 0.622 |
MET |
0.690 | 0.021 | 3 | 0.709 |
FGFR1 |
0.689 | -0.013 | 3 | 0.694 |
PTK2B |
0.689 | 0.082 | -1 | 0.739 |
LYN |
0.689 | 0.065 | 3 | 0.619 |
NTRK1 |
0.689 | 0.049 | -1 | 0.725 |
FYN |
0.689 | 0.069 | -1 | 0.709 |
TNK1 |
0.688 | -0.057 | 3 | 0.647 |
NTRK2 |
0.688 | 0.040 | 3 | 0.690 |
FGFR3 |
0.686 | 0.049 | 3 | 0.700 |
PDGFRA |
0.686 | -0.062 | 3 | 0.678 |
DDR2 |
0.685 | 0.064 | 3 | 0.673 |
INSR |
0.685 | -0.000 | 3 | 0.643 |
EPHA8 |
0.685 | 0.056 | -1 | 0.727 |
FLT4 |
0.683 | -0.016 | 3 | 0.668 |
CK1G3 |
0.683 | -0.005 | -3 | 0.426 |
ERBB2 |
0.682 | -0.038 | 1 | 0.650 |
NEK10_TYR |
0.682 | -0.108 | 1 | 0.577 |
PTK6 |
0.681 | -0.075 | -1 | 0.681 |
NTRK3 |
0.681 | 0.023 | -1 | 0.686 |
FLT1 |
0.680 | -0.035 | -1 | 0.712 |
WEE1_TYR |
0.680 | -0.066 | -1 | 0.689 |
TNNI3K_TYR |
0.679 | -0.132 | 1 | 0.683 |
EPHA2 |
0.678 | 0.066 | -1 | 0.710 |
MATK |
0.677 | -0.024 | -1 | 0.642 |
EGFR |
0.677 | 0.004 | 1 | 0.563 |
SRC |
0.676 | 0.005 | -1 | 0.711 |
FGFR4 |
0.675 | 0.028 | -1 | 0.684 |
IGF1R |
0.675 | 0.010 | 3 | 0.593 |
CSK |
0.675 | -0.035 | 2 | 0.740 |
PTK2 |
0.674 | 0.028 | -1 | 0.666 |
SYK |
0.670 | 0.023 | -1 | 0.661 |
ERBB4 |
0.670 | 0.024 | 1 | 0.594 |
YANK2 |
0.667 | -0.067 | 2 | 0.384 |
FES |
0.664 | 0.009 | -1 | 0.668 |
MUSK |
0.660 | -0.107 | 1 | 0.562 |
CK1G2 |
0.655 | -0.040 | -3 | 0.503 |
ZAP70 |
0.644 | -0.046 | -1 | 0.589 |