Motif 675 (n=126)

Position-wise Probabilities
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uniprot genes site source protein function
O00299 CLIC1 S221 ochoa Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}.
O14686 KMT2D S1722 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O75396 SEC22B S174 ochoa Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.
O75496 GMNN S34 ochoa Geminin Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}.
O94804 STK10 S514 ochoa Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
O94916 NFAT5 S238 ochoa Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
P02545 LMNA S282 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P06753 TPM3 S62 ochoa Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.
P06753 TPM3 S216 ochoa Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.
P07197 NEFM S783 ochoa Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}.
P07919 UQCRH S58 ochoa Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}.
P07942 LAMB1 S1222 ochoa Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.
P07951 TPM2 S61 ochoa Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.
P07951 TPM2 S215 ochoa Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.
P09493 TPM1 S61 psp Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
P09960 LTA4H S81 ochoa Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.
P17677 GAP43 S130 ochoa Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
P18583 SON S154 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P25205 MCM3 S734 ochoa DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}.
P27348 YWHAQ S92 ochoa 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
P30101 PDIA3 S163 ochoa Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
P30740 SERPINB1 S299 ochoa Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}.
P31629 HIVEP2 S1616 ochoa Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
P35367 HRH1 S318 ochoa Histamine H1 receptor (H1-R) (H1R) (HH1R) G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}.
P49902 NT5C2 S511 ochoa Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}.
P54278 PMS2 S403 ochoa Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}.
P60709 ACTB S234 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62495 ETF1 S123 ochoa Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}.
P62736 ACTA2 S236 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63261 ACTG1 S234 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 S235 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P67936 TPM4 S179 ochoa Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}.
P68032 ACTC1 S236 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68133 ACTA1 S236 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P78316 NOP14 S239 ochoa Nucleolar protein 14 (Nucleolar complex protein 14) Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.
Q01082 SPTBN1 S769 ochoa Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
Q01484 ANK2 S2248 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q01484 ANK2 S3910 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q02880 TOP2B S1413 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q02952 AKAP12 S1251 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164 KMT2A S1058 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q13315 ATM S1270 psp Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13416 ORC2 S219 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q13442 PDAP1 S57 ochoa 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.
Q13523 PRP4K S285 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q14126 DSG2 S553 ochoa Desmoglein-2 (Cadherin family member 5) (HDGC) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}.
Q14676 MDC1 S402 ochoa|psp Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14839 CHD4 S1245 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q15003 NCAPH S408 ochoa Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15293 RCN1 S158 ochoa Reticulocalbin-1 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q15643 TRIP11 S755 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q16513 PKN2 S167 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q16625 OCLN S490 psp Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q4KMP7 TBC1D10B S288 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q4LE39 ARID4B S772 ochoa AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.
Q53EZ4 CEP55 S162 ochoa Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}.
Q562R1 ACTBL2 S235 ochoa Beta-actin-like protein 2 (Kappa-actin) Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.
Q5JTJ3 COA6 S84 ochoa Cytochrome c oxidase assembly factor 6 homolog Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}.
Q5T5P2 KIAA1217 S1628 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T7W0 ZNF618 S429 ochoa Zinc finger protein 618 Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}.
Q5T9S5 CCDC18 S719 ochoa Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) None
Q5UIP0 RIF1 S1394 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5UIP0 RIF1 S1613 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q6S8J3 POTEE S934 ochoa POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) None
Q6UB98 ANKRD12 S1144 ochoa Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Q6ZNB6 NFXL1 S107 ochoa NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) None
Q7L7V1 DHX32 S561 ochoa Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) None
Q86U86 PBRM1 S605 ochoa Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q86UP2 KTN1 S1180 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86V21 AACS S84 ochoa Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}.
Q86VH2 KIF27 S911 ochoa Kinesin-like protein KIF27 Plays an essential role in motile ciliogenesis. {ECO:0000250}.
Q8IWT6 LRRC8A S199 ochoa Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:30095067). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). Acts as a key factor in NLRP3 inflammasome activation by modulating itaconate efflux and mitochondria function (PubMed:39909992). {ECO:0000250|UniProtKB:Q80WG5, ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:29371604, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122, ECO:0000269|PubMed:39909992}.
Q8IYS0 GRAMD1C S224 ochoa Protein Aster-C (GRAM domain-containing protein 1C) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}.
Q8NFG4 FLCN S537 psp Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}.
Q8TD26 CHD6 S1673 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8TDY2 RB1CC1 S1221 ochoa RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.
Q8WXW3 PIBF1 S703 ochoa Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.
Q8WZ42 TTN S4092 psp Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}.
Q92614 MYO18A S1527 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92622 RUBCN S473 ochoa Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}.
Q92833 JARID2 S821 ochoa Protein Jumonji (Jumonji/ARID domain-containing protein 2) Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q96HH9 GRAMD2B S29 ochoa GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) None
Q96NB3 ZNF830 S100 ochoa Zinc finger protein 830 (Coiled-coil domain-containing protein 16) May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}.
Q96RT1 ERBIN S603 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q99575 POP1 S371 ochoa Ribonucleases P/MRP protein subunit POP1 (hPOP1) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}.
Q99615 DNAJC7 S393 ochoa DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.
Q99816 TSG101 S309 ochoa Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.
Q9BW91 NUDT9 S118 ochoa ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}.
Q9BYW2 SETD2 S939 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BZ29 DOCK9 S927 ochoa Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.
Q9BZI7 UPF3B S416 ochoa Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Q9C0B0 UNK S447 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0B9 ZCCHC2 S490 ochoa Zinc finger CCHC domain-containing protein 2 None
Q9HAW4 CLSPN S958 ochoa Claspin (hClaspin) Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
Q9NP61 ARFGAP3 S212 ochoa ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}.
Q9NQ92 COPRS S138 ochoa Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}.
Q9NSV4 DIAPH3 S1127 ochoa Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}.
Q9NY72 SCN3B S196 ochoa Sodium channel regulatory subunit beta-3 Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:20558140, PubMed:21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed:20558140, PubMed:21051419, PubMed:24567321, PubMed:31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed:35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed:14975698). {ECO:0000250|UniProtKB:Q9JK00, ECO:0000269|PubMed:14975698, ECO:0000269|PubMed:20558140, ECO:0000269|PubMed:21051419, ECO:0000269|PubMed:24567321, ECO:0000269|PubMed:31950564, ECO:0000269|PubMed:35301303}.
Q9UGI8 TES S105 ochoa Testin (TESS) Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}.
Q9UHP3 USP25 S85 ochoa Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Q9UIG0 BAZ1B S508 ochoa Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}.
Q9UKF6 CPSF3 S659 ochoa Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). {ECO:0000250|UniProtKB:Q9QXK7, ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:15037765, ECO:0000269|PubMed:17128255, ECO:0000269|PubMed:18688255, ECO:0000269|PubMed:30507380}.
Q9UKL3 CASP8AP2 S928 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9ULW0 TPX2 S634 ochoa Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UPN3 MACF1 S4521 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPQ0 LIMCH1 S379 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UQR1 ZNF148 S438 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y2F5 ICE1 S393 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y2H5 PLEKHA6 S962 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y2K6 USP20 S265 ochoa Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}.
Q9Y3R5 DOP1B S580 ochoa Protein DOP1B May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q9Y496 KIF3A S388 ochoa Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}.
Q9Y4G2 PLEKHM1 S305 ochoa Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}.
P57721 PCBP3 S59 Sugiyama Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
P57723 PCBP4 S31 Sugiyama Poly(rC)-binding protein 4 (Alpha-CP4) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
Q15365 PCBP1 S27 Sugiyama Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15366 PCBP2 S27 Sugiyama Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
P14868 DARS1 S32 Sugiyama Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}.
Q7L5Y9 MAEA S226 Sugiyama E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}.
P17948 FLT1 S1031 Sugiyama Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}.
P35916 FLT4 S1046 Sugiyama Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.
Q86U86 PBRM1 S267 Sugiyama Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P10809 HSPD1 S159 Sugiyama 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.
Q01082 SPTBN1 S1666 Sugiyama Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
P63151 PPP2R2A S113 Sugiyama Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}.
P17987 TCP1 S119 Sugiyama T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
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reactome_id name p -log10_p
R-HSA-390522 Striated Muscle Contraction 6.768140e-08 7.170
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 4.005379e-08 7.397
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 8.974556e-07 6.047
R-HSA-3000171 Non-integrin membrane-ECM interactions 8.282964e-06 5.082
R-HSA-445095 Interaction between L1 and Ankyrins 1.078298e-05 4.967
R-HSA-445355 Smooth Muscle Contraction 1.589060e-05 4.799
R-HSA-9764561 Regulation of CDH1 Function 2.262576e-05 4.645
R-HSA-397014 Muscle contraction 3.353775e-05 4.474
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 8.042008e-05 4.095
R-HSA-373760 L1CAM interactions 1.377441e-04 3.861
R-HSA-3700989 Transcriptional Regulation by TP53 2.818076e-04 3.550
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.391760e-04 3.470
R-HSA-75153 Apoptotic execution phase 1.245797e-03 2.905
R-HSA-69481 G2/M Checkpoints 1.446027e-03 2.840
R-HSA-3247509 Chromatin modifying enzymes 1.585516e-03 2.800
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.671084e-03 2.777
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 2.199016e-03 2.658
R-HSA-194313 VEGF ligand-receptor interactions 2.199016e-03 2.658
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 2.199016e-03 2.658
R-HSA-4839726 Chromatin organization 2.258160e-03 2.646
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.697461e-03 2.569
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 2.767705e-03 2.558
R-HSA-68962 Activation of the pre-replicative complex 3.747229e-03 2.426
R-HSA-196025 Formation of annular gap junctions 4.088815e-03 2.388
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 4.088815e-03 2.388
R-HSA-190873 Gap junction degradation 4.839111e-03 2.315
R-HSA-176187 Activation of ATR in response to replication stress 4.677144e-03 2.330
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.291598e-03 2.276
R-HSA-9013694 Signaling by NOTCH4 5.521910e-03 2.258
R-HSA-390450 Folding of actin by CCT/TriC 5.647842e-03 2.248
R-HSA-9682385 FLT3 signaling in disease 6.116733e-03 2.213
R-HSA-9764265 Regulation of CDH1 Expression and Function 6.275605e-03 2.202
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 6.275605e-03 2.202
R-HSA-3214841 PKMTs methylate histone lysines 8.251274e-03 2.083
R-HSA-1640170 Cell Cycle 9.588553e-03 2.018
R-HSA-74160 Gene expression (Transcription) 9.361192e-03 2.029
R-HSA-69620 Cell Cycle Checkpoints 1.006528e-02 1.997
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.053243e-02 1.977
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.057973e-02 1.976
R-HSA-446353 Cell-extracellular matrix interactions 1.167060e-02 1.933
R-HSA-199991 Membrane Trafficking 1.213175e-02 1.916
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.247702e-02 1.904
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1.286026e-02 1.891
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.362378e-02 1.866
R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 1.687256e-02 1.773
R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 1.687256e-02 1.773
R-HSA-5693532 DNA Double-Strand Break Repair 1.594034e-02 1.798
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.672890e-02 1.777
R-HSA-73894 DNA Repair 1.648436e-02 1.783
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.773806e-02 1.751
R-HSA-418990 Adherens junctions interactions 1.665471e-02 1.778
R-HSA-73857 RNA Polymerase II Transcription 1.871290e-02 1.728
R-HSA-109581 Apoptosis 1.940820e-02 1.712
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.998326e-02 1.699
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 3.346247e-02 1.475
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 3.346247e-02 1.475
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 3.346247e-02 1.475
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 3.346247e-02 1.475
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 3.346247e-02 1.475
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 3.346247e-02 1.475
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 3.346247e-02 1.475
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 3.346247e-02 1.475
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 3.346247e-02 1.475
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 3.346247e-02 1.475
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 3.346247e-02 1.475
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 2.573329e-02 1.590
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 2.492252e-02 1.603
R-HSA-5693606 DNA Double Strand Break Response 2.670198e-02 1.573
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 3.045978e-02 1.516
R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 3.346247e-02 1.475
R-HSA-212165 Epigenetic regulation of gene expression 2.802469e-02 1.552
R-HSA-352238 Breakdown of the nuclear lamina 2.520255e-02 1.599
R-HSA-69473 G2/M DNA damage checkpoint 3.345134e-02 1.476
R-HSA-9932444 ATP-dependent chromatin remodelers 2.908474e-02 1.536
R-HSA-9932451 SWI/SNF chromatin remodelers 2.908474e-02 1.536
R-HSA-69052 Switching of origins to a post-replicative state 3.243773e-02 1.489
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 3.260008e-02 1.487
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.761660e-02 1.559
R-HSA-1474244 Extracellular matrix organization 3.117905e-02 1.506
R-HSA-194138 Signaling by VEGF 3.232515e-02 1.490
R-HSA-1500931 Cell-Cell communication 2.544929e-02 1.594
R-HSA-421270 Cell-cell junction organization 2.904645e-02 1.537
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 4.165291e-02 1.380
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 4.165291e-02 1.380
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 3.627292e-02 1.440
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 4.009702e-02 1.397
R-HSA-72163 mRNA Splicing - Major Pathway 3.622468e-02 1.441
R-HSA-5693607 Processing of DNA double-strand break ends 4.100251e-02 1.387
R-HSA-8856688 Golgi-to-ER retrograde transport 3.836827e-02 1.416
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 4.165291e-02 1.380
R-HSA-390650 Histamine receptors 4.165291e-02 1.380
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 4.001447e-02 1.398
R-HSA-9659379 Sensory processing of sound 3.876413e-02 1.412
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.030947e-02 1.395
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 3.987528e-02 1.399
R-HSA-446728 Cell junction organization 4.283308e-02 1.368
R-HSA-72172 mRNA Splicing 4.335073e-02 1.363
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 4.341080e-02 1.362
R-HSA-5357801 Programmed Cell Death 4.403752e-02 1.356
R-HSA-212436 Generic Transcription Pathway 4.499370e-02 1.347
R-HSA-6802957 Oncogenic MAPK signaling 4.567090e-02 1.340
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 5.458641e-02 1.263
R-HSA-5674135 MAP2K and MAPK activation 6.588929e-02 1.181
R-HSA-68867 Assembly of the pre-replicative complex 5.843323e-02 1.233
R-HSA-9656223 Signaling by RAF1 mutants 6.588929e-02 1.181
R-HSA-68689 CDC6 association with the ORC:origin complex 6.581311e-02 1.182
R-HSA-6807878 COPI-mediated anterograde transport 6.396106e-02 1.194
R-HSA-199977 ER to Golgi Anterograde Transport 5.321987e-02 1.274
R-HSA-69560 Transcriptional activation of p53 responsive genes 4.977445e-02 1.303
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 4.977445e-02 1.303
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 5.027963e-02 1.299
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 6.581311e-02 1.182
R-HSA-5653656 Vesicle-mediated transport 5.097268e-02 1.293
R-HSA-8878171 Transcriptional regulation by RUNX1 5.997550e-02 1.222
R-HSA-453279 Mitotic G1 phase and G1/S transition 5.227075e-02 1.282
R-HSA-422475 Axon guidance 5.341205e-02 1.272
R-HSA-8957275 Post-translational protein phosphorylation 6.681269e-02 1.175
R-HSA-3214858 RMTs methylate histone arginines 7.301225e-02 1.137
R-HSA-190828 Gap junction trafficking 7.301225e-02 1.137
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 7.301225e-02 1.137
R-HSA-3928662 EPHB-mediated forward signaling 7.301225e-02 1.137
R-HSA-9675108 Nervous system development 7.307102e-02 1.136
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 7.373137e-02 1.132
R-HSA-9860931 Response of endothelial cells to shear stress 7.570896e-02 1.121
R-HSA-72187 mRNA 3'-end processing 9.311290e-02 1.031
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 9.572812e-02 1.019
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.145917e-01 0.941
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.997291e-02 1.046
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.997291e-02 1.046
R-HSA-9664873 Pexophagy 1.047437e-01 0.980
R-HSA-69002 DNA Replication Pre-Initiation 8.509961e-02 1.070
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 9.328560e-02 1.030
R-HSA-5620924 Intraflagellar transport 8.287254e-02 1.082
R-HSA-5693538 Homology Directed Repair 1.035197e-01 0.985
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 7.789255e-02 1.109
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 7.789255e-02 1.109
R-HSA-9649948 Signaling downstream of RAS mutants 7.789255e-02 1.109
R-HSA-176974 Unwinding of DNA 9.708859e-02 1.013
R-HSA-6802949 Signaling by RAS mutants 7.789255e-02 1.109
R-HSA-9948001 CASP4 inflammasome assembly 1.047437e-01 0.980
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.123343e-01 0.949
R-HSA-3214815 HDACs deacetylate histones 1.010209e-01 0.996
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 1.047437e-01 0.980
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 8.539844e-02 1.069
R-HSA-69563 p53-Dependent G1 DNA Damage Response 8.539844e-02 1.069
R-HSA-983189 Kinesins 1.145917e-01 0.941
R-HSA-68949 Orc1 removal from chromatin 9.311290e-02 1.031
R-HSA-2980766 Nuclear Envelope Breakdown 1.063931e-01 0.973
R-HSA-437239 Recycling pathway of L1 8.037038e-02 1.095
R-HSA-9675135 Diseases of DNA repair 7.789255e-02 1.109
R-HSA-9855142 Cellular responses to mechanical stimuli 9.328560e-02 1.030
R-HSA-69239 Synthesis of DNA 8.191591e-02 1.087
R-HSA-8953854 Metabolism of RNA 1.138556e-01 0.944
R-HSA-157858 Gap junction trafficking and regulation 8.539844e-02 1.069
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 8.474613e-02 1.072
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 8.037038e-02 1.095
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.063931e-01 0.973
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 9.496075e-02 1.022
R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.198610e-01 0.921
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.198610e-01 0.921
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.637093e-01 0.786
R-HSA-9709603 Impaired BRCA2 binding to PALB2 1.848131e-01 0.733
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 1.917296e-01 0.717
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.917296e-01 0.717
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.917296e-01 0.717
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.917296e-01 0.717
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 1.917296e-01 0.717
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 2.254476e-01 0.647
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 2.320217e-01 0.634
R-HSA-390466 Chaperonin-mediated protein folding 1.970389e-01 0.705
R-HSA-3000157 Laminin interactions 2.320217e-01 0.634
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.637093e-01 0.786
R-HSA-391251 Protein folding 2.156000e-01 0.666
R-HSA-5358508 Mismatch Repair 1.778379e-01 0.750
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.273244e-01 0.895
R-HSA-174490 Membrane binding and targetting of GAG proteins 1.347249e-01 0.871
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.347249e-01 0.871
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1.708035e-01 0.768
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.254476e-01 0.647
R-HSA-9865881 Complex III assembly 2.254476e-01 0.647
R-HSA-73856 RNA Polymerase II Transcription Termination 1.173599e-01 0.930
R-HSA-1236974 ER-Phagosome pathway 2.032049e-01 0.692
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1.708035e-01 0.768
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.778379e-01 0.750
R-HSA-1268020 Mitochondrial protein import 1.201449e-01 0.920
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 1.420632e-01 0.848
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.493396e-01 0.826
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 1.786980e-01 0.748
R-HSA-69306 DNA Replication 1.791770e-01 0.747
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.371832e-01 0.863
R-HSA-5693548 Sensing of DNA Double Strand Breaks 1.198610e-01 0.921
R-HSA-9018681 Biosynthesis of protectins 1.420632e-01 0.848
R-HSA-1500620 Meiosis 1.878365e-01 0.726
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 2.254476e-01 0.647
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.778379e-01 0.750
R-HSA-948021 Transport to the Golgi and subsequent modification 1.206190e-01 0.919
R-HSA-113510 E2F mediated regulation of DNA replication 1.848131e-01 0.733
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.488211e-01 0.827
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.726458e-01 0.763
R-HSA-5635838 Activation of SMO 1.565548e-01 0.805
R-HSA-69615 G1/S DNA Damage Checkpoints 1.229464e-01 0.910
R-HSA-9612973 Autophagy 1.855269e-01 0.732
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.347249e-01 0.871
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.420632e-01 0.848
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 1.493396e-01 0.826
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.493396e-01 0.826
R-HSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins 1.708035e-01 0.768
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 1.917296e-01 0.717
R-HSA-9018676 Biosynthesis of D-series resolvins 2.121313e-01 0.673
R-HSA-9686114 Non-canonical inflammasome activation 1.420632e-01 0.848
R-HSA-9675151 Disorders of Developmental Biology 1.637093e-01 0.786
R-HSA-9755088 Ribavirin ADME 2.053882e-01 0.687
R-HSA-69206 G1/S Transition 1.178201e-01 0.929
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.939649e-01 0.712
R-HSA-9023661 Biosynthesis of E-series 18(R)-resolvins 1.420632e-01 0.848
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.493396e-01 0.826
R-HSA-2161541 Abacavir metabolism 1.985877e-01 0.702
R-HSA-77111 Synthesis of Ketone Bodies 1.917296e-01 0.717
R-HSA-175474 Assembly Of The HIV Virion 2.053882e-01 0.687
R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins 1.985877e-01 0.702
R-HSA-9629569 Protein hydroxylation 1.917296e-01 0.717
R-HSA-5633007 Regulation of TP53 Activity 1.940845e-01 0.712
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 2.053882e-01 0.687
R-HSA-74182 Ketone body metabolism 2.188176e-01 0.660
R-HSA-69242 S Phase 1.687340e-01 0.773
R-HSA-69278 Cell Cycle, Mitotic 1.288408e-01 0.890
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.778379e-01 0.750
R-HSA-373753 Nephrin family interactions 1.917296e-01 0.717
R-HSA-5689880 Ub-specific processing proteases 2.247517e-01 0.648
R-HSA-74259 Purine catabolism 1.488211e-01 0.827
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.565548e-01 0.805
R-HSA-5688426 Deubiquitination 2.075759e-01 0.683
R-HSA-8863678 Neurodegenerative Diseases 2.254476e-01 0.647
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.254476e-01 0.647
R-HSA-2682334 EPH-Ephrin signaling 2.156000e-01 0.666
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 1.285966e-01 0.891
R-HSA-381038 XBP1(S) activates chaperone genes 1.939649e-01 0.712
R-HSA-381070 IRE1alpha activates chaperones 2.124941e-01 0.673
R-HSA-157118 Signaling by NOTCH 1.817375e-01 0.741
R-HSA-9020591 Interleukin-12 signaling 1.606505e-01 0.794
R-HSA-447115 Interleukin-12 family signaling 1.970389e-01 0.705
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.385405e-01 0.622
R-HSA-8874081 MET activates PTK2 signaling 2.385405e-01 0.622
R-HSA-9638630 Attachment of bacteria to epithelial cells 2.385405e-01 0.622
R-HSA-70635 Urea cycle 2.385405e-01 0.622
R-HSA-2161522 Abacavir ADME 2.385405e-01 0.622
R-HSA-9614085 FOXO-mediated transcription 2.405762e-01 0.619
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.450043e-01 0.611
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.450043e-01 0.611
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 2.499832e-01 0.602
R-HSA-9842860 Regulation of endogenous retroelements 2.499832e-01 0.602
R-HSA-5576892 Phase 0 - rapid depolarisation 2.514136e-01 0.600
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.577689e-01 0.589
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 2.577689e-01 0.589
R-HSA-9615710 Late endosomal microautophagy 2.577689e-01 0.589
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.577689e-01 0.589
R-HSA-9018679 Biosynthesis of EPA-derived SPMs 2.577689e-01 0.589
R-HSA-597592 Post-translational protein modification 2.611942e-01 0.583
R-HSA-5696398 Nucleotide Excision Repair 2.625428e-01 0.581
R-HSA-5617833 Cilium Assembly 2.631334e-01 0.580
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.640707e-01 0.578
R-HSA-8863795 Downregulation of ERBB2 signaling 2.640707e-01 0.578
R-HSA-114452 Activation of BH3-only proteins 2.640707e-01 0.578
R-HSA-9692914 SARS-CoV-1-host interactions 2.656840e-01 0.576
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.688254e-01 0.571
R-HSA-9700206 Signaling by ALK in cancer 2.688254e-01 0.571
R-HSA-162588 Budding and maturation of HIV virion 2.703193e-01 0.568
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 2.703193e-01 0.568
R-HSA-5694530 Cargo concentration in the ER 2.703193e-01 0.568
R-HSA-1236975 Antigen processing-Cross presentation 2.719666e-01 0.565
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.719666e-01 0.565
R-HSA-69190 DNA strand elongation 2.765153e-01 0.558
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 2.826590e-01 0.549
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.826590e-01 0.549
R-HSA-68616 Assembly of the ORC complex at the origin of replication 2.826590e-01 0.549
R-HSA-1839124 FGFR1 mutant receptor activation 2.826590e-01 0.549
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 2.826590e-01 0.549
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.826590e-01 0.549
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.826590e-01 0.549
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 2.887509e-01 0.539
R-HSA-5693537 Resolution of D-Loop Structures 2.887509e-01 0.539
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.887509e-01 0.539
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 2.887509e-01 0.539
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 2.887509e-01 0.539
R-HSA-5223345 Miscellaneous transport and binding events 2.887509e-01 0.539
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2.947915e-01 0.530
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 2.947915e-01 0.530
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 2.947915e-01 0.530
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.947915e-01 0.530
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 2.947915e-01 0.530
R-HSA-901042 Calnexin/calreticulin cycle 2.947915e-01 0.530
R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 2.947915e-01 0.530
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.954466e-01 0.530
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.001963e-01 0.523
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 3.007812e-01 0.522
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 3.007812e-01 0.522
R-HSA-212300 PRC2 methylates histones and DNA 3.067203e-01 0.513
R-HSA-6804757 Regulation of TP53 Degradation 3.067203e-01 0.513
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.126094e-01 0.505
R-HSA-68875 Mitotic Prophase 3.158123e-01 0.501
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 3.184488e-01 0.497
R-HSA-9931953 Biofilm formation 3.184488e-01 0.497
R-HSA-8875878 MET promotes cell motility 3.184488e-01 0.497
R-HSA-3371556 Cellular response to heat stress 3.189269e-01 0.496
R-HSA-69541 Stabilization of p53 3.242389e-01 0.489
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.242389e-01 0.489
R-HSA-6806003 Regulation of TP53 Expression and Degradation 3.242389e-01 0.489
R-HSA-68882 Mitotic Anaphase 3.254523e-01 0.488
R-HSA-446203 Asparagine N-linked glycosylation 3.254788e-01 0.487
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.277721e-01 0.484
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.299802e-01 0.482
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.299802e-01 0.482
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.299802e-01 0.482
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.299802e-01 0.482
R-HSA-5655302 Signaling by FGFR1 in disease 3.413180e-01 0.467
R-HSA-6811438 Intra-Golgi traffic 3.413180e-01 0.467
R-HSA-8956319 Nucleotide catabolism 3.467925e-01 0.460
R-HSA-379716 Cytosolic tRNA aminoacylation 3.469152e-01 0.460
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.469152e-01 0.460
R-HSA-8854214 TBC/RABGAPs 3.524653e-01 0.453
R-HSA-1474165 Reproduction 3.529374e-01 0.452
R-HSA-69236 G1 Phase 3.579685e-01 0.446
R-HSA-69231 Cyclin D associated events in G1 3.579685e-01 0.446
R-HSA-375280 Amine ligand-binding receptors 3.579685e-01 0.446
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 3.579685e-01 0.446
R-HSA-5683826 Surfactant metabolism 3.579685e-01 0.446
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.634253e-01 0.440
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 3.688360e-01 0.433
R-HSA-9861718 Regulation of pyruvate metabolism 3.688360e-01 0.433
R-HSA-9031628 NGF-stimulated transcription 3.795209e-01 0.421
R-HSA-381119 Unfolded Protein Response (UPR) 3.833445e-01 0.416
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.847958e-01 0.415
R-HSA-9664422 FCGR3A-mediated phagocytosis 3.863532e-01 0.413
R-HSA-9664417 Leishmania phagocytosis 3.863532e-01 0.413
R-HSA-9664407 Parasite infection 3.863532e-01 0.413
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.893555e-01 0.410
R-HSA-1632852 Macroautophagy 3.893555e-01 0.410
R-HSA-912446 Meiotic recombination 3.952124e-01 0.403
R-HSA-8856828 Clathrin-mediated endocytosis 3.983236e-01 0.400
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 4.003549e-01 0.398
R-HSA-1221632 Meiotic synapsis 4.054539e-01 0.392
R-HSA-9639288 Amino acids regulate mTORC1 4.054539e-01 0.392
R-HSA-8953897 Cellular responses to stimuli 4.065119e-01 0.391
R-HSA-9679191 Potential therapeutics for SARS 4.190093e-01 0.378
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 4.204943e-01 0.376
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.204943e-01 0.376
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.248544e-01 0.372
R-HSA-9609507 Protein localization 4.277657e-01 0.369
R-HSA-6782135 Dual incision in TC-NER 4.303107e-01 0.366
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 4.303107e-01 0.366
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.306693e-01 0.366
R-HSA-9734767 Developmental Cell Lineages 4.332397e-01 0.363
R-HSA-379724 tRNA Aminoacylation 4.399620e-01 0.357
R-HSA-1227986 Signaling by ERBB2 4.399620e-01 0.357
R-HSA-8943724 Regulation of PTEN gene transcription 4.399620e-01 0.357
R-HSA-162582 Signal Transduction 4.426181e-01 0.354
R-HSA-68886 M Phase 4.490681e-01 0.348
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.494510e-01 0.347
R-HSA-375165 NCAM signaling for neurite out-growth 4.494510e-01 0.347
R-HSA-6784531 tRNA processing in the nucleus 4.494510e-01 0.347
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.494510e-01 0.347
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.494510e-01 0.347
R-HSA-983169 Class I MHC mediated antigen processing & presentation 4.509459e-01 0.346
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.541355e-01 0.343
R-HSA-8854518 AURKA Activation by TPX2 4.679528e-01 0.330
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.679528e-01 0.330
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.724810e-01 0.326
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 4.814229e-01 0.317
R-HSA-204005 COPII-mediated vesicle transport 4.858373e-01 0.314
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 4.858373e-01 0.314
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 4.897565e-01 0.310
R-HSA-427413 NoRC negatively regulates rRNA expression 4.902143e-01 0.310
R-HSA-5632684 Hedgehog 'on' state 4.902143e-01 0.310
R-HSA-3000178 ECM proteoglycans 4.902143e-01 0.310
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.902143e-01 0.310
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 4.902143e-01 0.310
R-HSA-5673001 RAF/MAP kinase cascade 4.903173e-01 0.310
R-HSA-9678108 SARS-CoV-1 Infection 4.924751e-01 0.308
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.945544e-01 0.306
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 4.988577e-01 0.302
R-HSA-1226099 Signaling by FGFR in disease 5.031247e-01 0.298
R-HSA-5684996 MAPK1/MAPK3 signaling 5.052166e-01 0.297
R-HSA-392499 Metabolism of proteins 5.053906e-01 0.296
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 5.073557e-01 0.295
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 5.073557e-01 0.295
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.115509e-01 0.291
R-HSA-5689603 UCH proteinases 5.115509e-01 0.291
R-HSA-1266738 Developmental Biology 5.121092e-01 0.291
R-HSA-73864 RNA Polymerase I Transcription 5.198351e-01 0.284
R-HSA-69275 G2/M Transition 5.217740e-01 0.283
R-HSA-453274 Mitotic G2-G2/M phases 5.269796e-01 0.278
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 5.279798e-01 0.277
R-HSA-6806834 Signaling by MET 5.279798e-01 0.277
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 5.320006e-01 0.274
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 5.438601e-01 0.265
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.438601e-01 0.265
R-HSA-1852241 Organelle biogenesis and maintenance 5.545393e-01 0.256
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 5.554212e-01 0.255
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 5.554212e-01 0.255
R-HSA-70268 Pyruvate metabolism 5.592099e-01 0.252
R-HSA-9663891 Selective autophagy 5.629665e-01 0.250
R-HSA-9645723 Diseases of programmed cell death 5.629665e-01 0.250
R-HSA-376176 Signaling by ROBO receptors 5.647984e-01 0.248
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 5.776779e-01 0.238
R-HSA-6798695 Neutrophil degranulation 5.825409e-01 0.235
R-HSA-9837999 Mitochondrial protein degradation 5.883878e-01 0.230
R-HSA-9730414 MITF-M-regulated melanocyte development 5.911373e-01 0.228
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.918975e-01 0.228
R-HSA-72764 Eukaryotic Translation Termination 5.953775e-01 0.225
R-HSA-5683057 MAPK family signaling cascades 6.064326e-01 0.217
R-HSA-3214847 HATs acetylate histones 6.090054e-01 0.215
R-HSA-5610787 Hedgehog 'off' state 6.123405e-01 0.213
R-HSA-1483255 PI Metabolism 6.189264e-01 0.208
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 6.285974e-01 0.202
R-HSA-5619507 Activation of HOX genes during differentiation 6.285974e-01 0.202
R-HSA-15869 Metabolism of nucleotides 6.423575e-01 0.192
R-HSA-2262752 Cellular responses to stress 6.644472e-01 0.178
R-HSA-5628897 TP53 Regulates Metabolic Genes 6.649049e-01 0.177
R-HSA-9007101 Rab regulation of trafficking 6.734169e-01 0.172
R-HSA-9759194 Nuclear events mediated by NFE2L2 6.844333e-01 0.165
R-HSA-2132295 MHC class II antigen presentation 6.898024e-01 0.161
R-HSA-6809371 Formation of the cornified envelope 6.924528e-01 0.160
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 6.976864e-01 0.156
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 6.976864e-01 0.156
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 6.976864e-01 0.156
R-HSA-114608 Platelet degranulation 7.028315e-01 0.153
R-HSA-187037 Signaling by NTRK1 (TRKA) 7.053714e-01 0.152
R-HSA-9843745 Adipogenesis 7.153172e-01 0.146
R-HSA-5576891 Cardiac conduction 7.153172e-01 0.146
R-HSA-9909396 Circadian clock 7.177512e-01 0.144
R-HSA-1474228 Degradation of the extracellular matrix 7.177512e-01 0.144
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.201645e-01 0.143
R-HSA-9679506 SARS-CoV Infections 7.257703e-01 0.139
R-HSA-9658195 Leishmania infection 7.278671e-01 0.138
R-HSA-9824443 Parasitic Infection Pathways 7.278671e-01 0.138
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.295559e-01 0.137
R-HSA-5358351 Signaling by Hedgehog 7.342199e-01 0.134
R-HSA-6807070 PTEN Regulation 7.364934e-01 0.133
R-HSA-162599 Late Phase of HIV Life Cycle 7.453957e-01 0.128
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 7.475743e-01 0.126
R-HSA-166520 Signaling by NTRKs 7.581925e-01 0.120
R-HSA-9758941 Gastrulation 7.602623e-01 0.119
R-HSA-9856651 MITF-M-dependent gene expression 7.623145e-01 0.118
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.643493e-01 0.117
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 7.663668e-01 0.116
R-HSA-2142753 Arachidonate metabolism 7.663668e-01 0.116
R-HSA-9610379 HCMV Late Events 7.761999e-01 0.110
R-HSA-162587 HIV Life Cycle 7.761999e-01 0.110
R-HSA-9711097 Cellular response to starvation 7.781167e-01 0.109
R-HSA-2408522 Selenoamino acid metabolism 7.892798e-01 0.103
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 8.016004e-01 0.096
R-HSA-72306 tRNA processing 8.016004e-01 0.096
R-HSA-9909648 Regulation of PD-L1(CD274) expression 8.049873e-01 0.094
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.145795e-01 0.089
R-HSA-611105 Respiratory electron transport 8.148075e-01 0.089
R-HSA-2559583 Cellular Senescence 8.179706e-01 0.087
R-HSA-109582 Hemostasis 8.198158e-01 0.086
R-HSA-201681 TCF dependent signaling in response to WNT 8.226148e-01 0.085
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.300953e-01 0.081
R-HSA-68877 Mitotic Prometaphase 8.372625e-01 0.077
R-HSA-389948 Co-inhibition by PD-1 8.467951e-01 0.072
R-HSA-9640148 Infection with Enterobacteria 8.507088e-01 0.070
R-HSA-6805567 Keratinization 8.557731e-01 0.068
R-HSA-9748784 Drug ADME 8.699651e-01 0.060
R-HSA-8951664 Neddylation 8.732909e-01 0.059
R-HSA-162906 HIV Infection 8.796911e-01 0.056
R-HSA-9705683 SARS-CoV-2-host interactions 8.807262e-01 0.055
R-HSA-72312 rRNA processing 8.847787e-01 0.053
R-HSA-1280218 Adaptive Immune System 8.969959e-01 0.047
R-HSA-72766 Translation 8.983196e-01 0.047
R-HSA-9609646 HCMV Infection 9.013881e-01 0.045
R-HSA-1643685 Disease 9.053818e-01 0.043
R-HSA-388841 Regulation of T cell activation by CD28 family 9.063780e-01 0.043
R-HSA-416476 G alpha (q) signalling events 9.126434e-01 0.040
R-HSA-9711123 Cellular response to chemical stress 9.156181e-01 0.038
R-HSA-76002 Platelet activation, signaling and aggregation 9.198927e-01 0.036
R-HSA-1257604 PIP3 activates AKT signaling 9.332295e-01 0.030
R-HSA-1483257 Phospholipid metabolism 9.332295e-01 0.030
R-HSA-195721 Signaling by WNT 9.349454e-01 0.029
R-HSA-168249 Innate Immune System 9.468069e-01 0.024
R-HSA-9006925 Intracellular signaling by second messengers 9.556190e-01 0.020
R-HSA-9694516 SARS-CoV-2 Infection 9.582427e-01 0.019
R-HSA-9824446 Viral Infection Pathways 9.704265e-01 0.013
R-HSA-9824439 Bacterial Infection Pathways 9.710468e-01 0.013
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.720406e-01 0.012
R-HSA-71291 Metabolism of amino acids and derivatives 9.740339e-01 0.011
R-HSA-8978868 Fatty acid metabolism 9.750424e-01 0.011
R-HSA-449147 Signaling by Interleukins 9.753589e-01 0.011
R-HSA-5663205 Infectious disease 9.819962e-01 0.008
R-HSA-168256 Immune System 9.858893e-01 0.006
R-HSA-500792 GPCR ligand binding 9.949611e-01 0.002
R-HSA-9709957 Sensory Perception 9.988500e-01 0.000
R-HSA-388396 GPCR downstream signalling 9.990282e-01 0.000
R-HSA-1280215 Cytokine Signaling in Immune system 9.992901e-01 0.000
R-HSA-372790 Signaling by GPCR 9.995386e-01 0.000
R-HSA-556833 Metabolism of lipids 9.998395e-01 0.000
R-HSA-382551 Transport of small molecules 9.998495e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.833 0.178 2 0.816
CDC7CDC7 0.829 0.191 1 0.854
MOSMOS 0.822 0.202 1 0.811
CLK3CLK3 0.816 0.110 1 0.727
BMPR1BBMPR1B 0.816 0.276 1 0.833
DSTYKDSTYK 0.813 0.017 2 0.826
PRPKPRPK 0.813 -0.041 -1 0.800
GRK6GRK6 0.813 0.174 1 0.809
RAF1RAF1 0.813 -0.024 1 0.773
GRK1GRK1 0.813 0.146 -2 0.702
PIM3PIM3 0.813 0.028 -3 0.713
CAMK2GCAMK2G 0.813 0.040 2 0.798
RSK2RSK2 0.813 0.059 -3 0.664
GCN2GCN2 0.812 -0.069 2 0.760
IKKBIKKB 0.811 -0.052 -2 0.666
TBK1TBK1 0.811 -0.054 1 0.665
MTORMTOR 0.810 -0.069 1 0.676
CAMK1BCAMK1B 0.809 -0.010 -3 0.763
NDR2NDR2 0.809 -0.012 -3 0.712
ATRATR 0.809 0.030 1 0.769
BMPR2BMPR2 0.808 -0.027 -2 0.799
FAM20CFAM20C 0.807 0.133 2 0.615
IKKEIKKE 0.806 -0.080 1 0.663
ULK2ULK2 0.806 -0.123 2 0.747
MST4MST4 0.805 0.042 2 0.800
NLKNLK 0.805 -0.032 1 0.706
TGFBR2TGFBR2 0.805 -0.001 -2 0.723
CDKL1CDKL1 0.805 -0.004 -3 0.698
IKKAIKKA 0.805 0.028 -2 0.653
GRK5GRK5 0.805 -0.000 -3 0.765
PRKD1PRKD1 0.804 -0.011 -3 0.687
PDHK4PDHK4 0.804 -0.246 1 0.752
PIM1PIM1 0.804 0.044 -3 0.670
PRKD2PRKD2 0.804 0.020 -3 0.648
PKN3PKN3 0.804 -0.011 -3 0.700
BMPR1ABMPR1A 0.803 0.257 1 0.833
TGFBR1TGFBR1 0.802 0.131 -2 0.710
P90RSKP90RSK 0.802 -0.002 -3 0.655
SKMLCKSKMLCK 0.802 -0.002 -2 0.760
RIPK3RIPK3 0.802 -0.064 3 0.697
PKCDPKCD 0.801 0.039 2 0.759
RSK3RSK3 0.801 0.001 -3 0.667
ATMATM 0.801 0.075 1 0.752
KISKIS 0.801 0.013 1 0.572
NEK6NEK6 0.801 -0.064 -2 0.779
NDR1NDR1 0.801 -0.035 -3 0.709
ACVR2BACVR2B 0.801 0.184 -2 0.727
P70S6KBP70S6KB 0.801 0.017 -3 0.687
MLK1MLK1 0.801 -0.031 2 0.768
NIKNIK 0.801 -0.052 -3 0.772
WNK1WNK1 0.801 -0.049 -2 0.790
PDHK1PDHK1 0.800 -0.205 1 0.745
DAPK2DAPK2 0.800 -0.011 -3 0.751
ERK5ERK5 0.800 -0.051 1 0.648
CAMLCKCAMLCK 0.799 -0.036 -2 0.765
AMPKA1AMPKA1 0.799 -0.011 -3 0.725
GRK4GRK4 0.799 -0.009 -2 0.732
PKN2PKN2 0.799 -0.010 -3 0.717
PLK1PLK1 0.799 0.068 -2 0.748
MARK4MARK4 0.798 -0.050 4 0.785
MAPKAPK2MAPKAPK2 0.798 0.021 -3 0.613
CAMK2BCAMK2B 0.798 0.060 2 0.770
ACVR2AACVR2A 0.798 0.156 -2 0.713
GRK7GRK7 0.798 0.144 1 0.715
ALK4ALK4 0.798 0.082 -2 0.736
NUAK2NUAK2 0.798 -0.037 -3 0.720
NEK7NEK7 0.797 -0.156 -3 0.724
TSSK2TSSK2 0.797 0.015 -5 0.801
RSK4RSK4 0.797 0.056 -3 0.627
CDKL5CDKL5 0.797 -0.024 -3 0.680
SRPK1SRPK1 0.797 -0.000 -3 0.646
ALK2ALK2 0.797 0.163 -2 0.723
ULK1ULK1 0.797 -0.146 -3 0.705
LATS2LATS2 0.797 -0.037 -5 0.734
PKACGPKACG 0.797 -0.004 -2 0.695
WNK3WNK3 0.796 -0.157 1 0.704
BCKDKBCKDK 0.796 -0.125 -1 0.787
CAMK2DCAMK2D 0.796 -0.057 -3 0.711
HUNKHUNK 0.795 -0.110 2 0.740
PLK3PLK3 0.795 0.116 2 0.731
MAPKAPK3MAPKAPK3 0.795 -0.048 -3 0.645
CHAK2CHAK2 0.795 -0.085 -1 0.783
NIM1NIM1 0.794 -0.050 3 0.721
TSSK1TSSK1 0.793 -0.009 -3 0.738
SRPK2SRPK2 0.793 0.005 -3 0.580
CAMK2ACAMK2A 0.793 0.036 2 0.775
ICKICK 0.792 -0.040 -3 0.717
ANKRD3ANKRD3 0.792 -0.100 1 0.762
AMPKA2AMPKA2 0.792 -0.023 -3 0.695
HIPK4HIPK4 0.792 -0.064 1 0.647
MLK3MLK3 0.792 0.030 2 0.710
DLKDLK 0.792 -0.110 1 0.757
AURCAURC 0.791 0.004 -2 0.598
PAK1PAK1 0.791 -0.032 -2 0.697
PRKXPRKX 0.791 0.073 -3 0.564
DNAPKDNAPK 0.790 0.063 1 0.683
CK2A2CK2A2 0.790 0.238 1 0.721
PRKD3PRKD3 0.790 -0.020 -3 0.652
TTBK2TTBK2 0.789 -0.121 2 0.642
IRE2IRE2 0.789 -0.024 2 0.751
PKACBPKACB 0.789 0.023 -2 0.623
MLK4MLK4 0.789 0.020 2 0.681
LATS1LATS1 0.788 0.006 -3 0.714
CDK8CDK8 0.788 -0.040 1 0.550
MSK2MSK2 0.788 -0.054 -3 0.633
MASTLMASTL 0.788 -0.266 -2 0.731
PKCBPKCB 0.788 0.011 2 0.703
PKRPKR 0.788 -0.014 1 0.721
PKCGPKCG 0.788 0.004 2 0.704
PKCAPKCA 0.787 0.003 2 0.702
CAMK4CAMK4 0.787 -0.094 -3 0.707
NEK9NEK9 0.787 -0.206 2 0.782
MLK2MLK2 0.787 -0.141 2 0.767
JNK2JNK2 0.787 0.025 1 0.518
MSK1MSK1 0.786 -0.015 -3 0.633
RIPK1RIPK1 0.786 -0.204 1 0.710
SIKSIK 0.786 -0.046 -3 0.657
PAK3PAK3 0.786 -0.083 -2 0.698
QSKQSK 0.786 -0.050 4 0.761
MELKMELK 0.786 -0.066 -3 0.679
IRE1IRE1 0.785 -0.099 1 0.657
AURBAURB 0.785 -0.016 -2 0.591
GRK2GRK2 0.785 0.033 -2 0.618
SRPK3SRPK3 0.785 -0.020 -3 0.636
MNK2MNK2 0.785 -0.044 -2 0.717
NUAK1NUAK1 0.785 -0.073 -3 0.683
SGK3SGK3 0.785 0.011 -3 0.638
QIKQIK 0.784 -0.104 -3 0.713
BRAFBRAF 0.784 0.031 -4 0.769
BRSK1BRSK1 0.784 -0.046 -3 0.678
MEK1MEK1 0.784 -0.128 2 0.777
PKG2PKG2 0.784 0.001 -2 0.642
PKCHPKCH 0.784 -0.021 2 0.699
SMG1SMG1 0.783 -0.021 1 0.721
CDK1CDK1 0.783 -0.000 1 0.530
MARK2MARK2 0.783 -0.040 4 0.688
PAK6PAK6 0.783 -0.030 -2 0.622
AKT2AKT2 0.783 0.007 -3 0.593
MYLK4MYLK4 0.783 -0.039 -2 0.684
JNK3JNK3 0.783 0.007 1 0.541
YSK4YSK4 0.783 -0.101 1 0.689
DRAK1DRAK1 0.783 0.008 1 0.762
MARK3MARK3 0.783 -0.036 4 0.721
DYRK2DYRK2 0.782 -0.040 1 0.570
AURAAURA 0.781 -0.017 -2 0.544
CDK5CDK5 0.781 -0.003 1 0.570
CDK19CDK19 0.781 -0.045 1 0.516
CLK4CLK4 0.781 -0.035 -3 0.661
PIM2PIM2 0.781 0.002 -3 0.642
CLK2CLK2 0.781 0.035 -3 0.645
PLK2PLK2 0.781 0.217 -3 0.883
P38AP38A 0.781 -0.009 1 0.561
CDK7CDK7 0.780 -0.065 1 0.558
PLK4PLK4 0.780 -0.072 2 0.620
PAK2PAK2 0.780 -0.089 -2 0.680
VRK2VRK2 0.779 -0.228 1 0.753
CLK1CLK1 0.779 -0.028 -3 0.652
TLK2TLK2 0.779 -0.071 1 0.702
MNK1MNK1 0.779 -0.040 -2 0.731
CK2A1CK2A1 0.778 0.201 1 0.702
MARK1MARK1 0.778 -0.060 4 0.746
CDK18CDK18 0.778 -0.017 1 0.486
NEK2NEK2 0.778 -0.150 2 0.754
BRSK2BRSK2 0.777 -0.115 -3 0.692
P38BP38B 0.777 -0.006 1 0.507
CHK1CHK1 0.777 -0.068 -3 0.710
ERK1ERK1 0.777 -0.014 1 0.498
PHKG1PHKG1 0.777 -0.113 -3 0.698
CHAK1CHAK1 0.777 -0.138 2 0.710
P38GP38G 0.776 -0.004 1 0.443
PERKPERK 0.776 -0.105 -2 0.768
PKCZPKCZ 0.776 -0.095 2 0.731
MEKK3MEKK3 0.776 -0.074 1 0.713
ERK2ERK2 0.775 -0.031 1 0.534
CK1ECK1E 0.774 -0.032 -3 0.496
SMMLCKSMMLCK 0.774 -0.037 -3 0.714
GRK3GRK3 0.774 0.030 -2 0.572
SSTKSSTK 0.774 -0.011 4 0.766
ZAKZAK 0.774 -0.076 1 0.709
CDK17CDK17 0.774 -0.025 1 0.448
CDK2CDK2 0.774 -0.054 1 0.605
DCAMKL1DCAMKL1 0.773 -0.055 -3 0.667
HIPK1HIPK1 0.773 -0.024 1 0.580
HIPK2HIPK2 0.773 -0.018 1 0.486
MST3MST3 0.773 0.003 2 0.772
AKT1AKT1 0.773 -0.003 -3 0.595
PKACAPKACA 0.773 -0.003 -2 0.584
CDK13CDK13 0.772 -0.076 1 0.531
CAMK1GCAMK1G 0.772 -0.083 -3 0.659
MEKK1MEKK1 0.772 -0.136 1 0.716
MEKK2MEKK2 0.771 -0.057 2 0.757
TAO3TAO3 0.771 -0.029 1 0.699
WNK4WNK4 0.771 -0.125 -2 0.784
CDK16CDK16 0.771 0.021 1 0.459
IRAK4IRAK4 0.771 -0.104 1 0.677
HRIHRI 0.771 -0.174 -2 0.770
P70S6KP70S6K 0.771 -0.037 -3 0.605
SNRKSNRK 0.771 -0.195 2 0.670
DAPK3DAPK3 0.771 0.017 -3 0.686
PKCTPKCT 0.771 -0.042 2 0.707
P38DP38D 0.770 0.001 1 0.463
DYRK1ADYRK1A 0.770 -0.049 1 0.604
MEK5MEK5 0.769 -0.218 2 0.770
CDK3CDK3 0.769 -0.010 1 0.466
PASKPASK 0.769 -0.019 -3 0.728
PHKG2PHKG2 0.769 -0.083 -3 0.697
CAMK1DCAMK1D 0.768 -0.034 -3 0.592
DCAMKL2DCAMKL2 0.768 -0.074 -3 0.701
NEK5NEK5 0.768 -0.162 1 0.710
PRP4PRP4 0.768 -0.086 -3 0.602
TLK1TLK1 0.767 -0.119 -2 0.734
CDK14CDK14 0.766 -0.032 1 0.531
DYRK4DYRK4 0.766 -0.034 1 0.508
PINK1PINK1 0.766 -0.197 1 0.669
DYRK1BDYRK1B 0.765 -0.041 1 0.526
CDK12CDK12 0.765 -0.078 1 0.508
DAPK1DAPK1 0.765 0.004 -3 0.674
MAPKAPK5MAPKAPK5 0.765 -0.176 -3 0.593
HIPK3HIPK3 0.765 -0.067 1 0.570
PKCEPKCE 0.765 0.006 2 0.693
CAMKK1CAMKK1 0.764 -0.137 -2 0.703
GAKGAK 0.764 -0.021 1 0.715
NEK11NEK11 0.764 -0.125 1 0.717
SGK1SGK1 0.764 0.014 -3 0.515
TTBK1TTBK1 0.764 -0.147 2 0.568
TAO2TAO2 0.764 -0.072 2 0.810
CDK10CDK10 0.763 -0.015 1 0.520
CK1DCK1D 0.763 -0.049 -3 0.442
MST2MST2 0.763 -0.025 1 0.731
CK1A2CK1A2 0.762 -0.048 -3 0.447
JNK1JNK1 0.762 -0.009 1 0.505
MPSK1MPSK1 0.762 -0.077 1 0.622
AKT3AKT3 0.762 -0.001 -3 0.526
IRAK1IRAK1 0.761 -0.211 -1 0.727
CK1G1CK1G1 0.761 -0.093 -3 0.499
DYRK3DYRK3 0.760 -0.059 1 0.583
CDK9CDK9 0.760 -0.113 1 0.538
NEK8NEK8 0.760 -0.156 2 0.775
PKCIPKCI 0.760 -0.081 2 0.699
PAK5PAK5 0.760 -0.085 -2 0.554
CAMKK2CAMKK2 0.760 -0.145 -2 0.702
GCKGCK 0.760 -0.037 1 0.721
TAK1TAK1 0.760 -0.049 1 0.746
EEF2KEEF2K 0.759 -0.016 3 0.757
GSK3AGSK3A 0.759 -0.032 4 0.372
MINKMINK 0.759 -0.040 1 0.701
MRCKBMRCKB 0.759 -0.007 -3 0.635
GSK3BGSK3B 0.759 -0.066 4 0.361
MAP3K15MAP3K15 0.758 -0.076 1 0.678
ROCK2ROCK2 0.758 0.010 -3 0.660
TNIKTNIK 0.758 -0.016 3 0.766
PDK1PDK1 0.757 -0.135 1 0.702
MRCKAMRCKA 0.757 -0.019 -3 0.644
PAK4PAK4 0.757 -0.081 -2 0.553
HGKHGK 0.757 -0.066 3 0.765
PKN1PKN1 0.756 -0.063 -3 0.615
MEKK6MEKK6 0.756 -0.105 1 0.677
CAMK1ACAMK1A 0.755 -0.048 -3 0.574
NEK4NEK4 0.755 -0.165 1 0.686
HPK1HPK1 0.754 -0.054 1 0.714
MAKMAK 0.753 0.005 -2 0.686
LKB1LKB1 0.753 -0.174 -3 0.684
BUB1BUB1 0.753 0.012 -5 0.789
CHK2CHK2 0.753 -0.064 -3 0.546
LOKLOK 0.753 -0.091 -2 0.720
ERK7ERK7 0.753 -0.052 2 0.478
TTKTTK 0.752 0.069 -2 0.748
KHS2KHS2 0.751 -0.005 1 0.708
KHS1KHS1 0.751 -0.035 1 0.691
DMPK1DMPK1 0.751 0.021 -3 0.662
CDK6CDK6 0.751 -0.048 1 0.507
VRK1VRK1 0.751 -0.163 2 0.801
MST1MST1 0.750 -0.086 1 0.700
SBKSBK 0.750 -0.029 -3 0.490
LRRK2LRRK2 0.750 -0.191 2 0.795
CDK4CDK4 0.749 -0.054 1 0.493
MEK2MEK2 0.747 -0.212 2 0.760
NEK1NEK1 0.747 -0.182 1 0.685
PKG1PKG1 0.747 -0.042 -2 0.590
MOKMOK 0.747 -0.024 1 0.571
SLKSLK 0.747 -0.118 -2 0.655
PDHK3_TYRPDHK3_TYR 0.746 0.117 4 0.847
YSK1YSK1 0.746 -0.096 2 0.755
ALPHAK3ALPHAK3 0.745 0.066 -1 0.711
RIPK2RIPK2 0.744 -0.244 1 0.675
PBKPBK 0.744 -0.076 1 0.617
ROCK1ROCK1 0.744 -0.013 -3 0.638
STK33STK33 0.743 -0.191 2 0.565
CRIKCRIK 0.742 -0.001 -3 0.590
EPHA6EPHA6 0.741 0.163 -1 0.838
OSR1OSR1 0.740 -0.067 2 0.727
HASPINHASPIN 0.739 -0.020 -1 0.673
BMPR2_TYRBMPR2_TYR 0.738 0.082 -1 0.831
TXKTXK 0.738 0.216 1 0.802
ASK1ASK1 0.737 -0.092 1 0.674
PDHK4_TYRPDHK4_TYR 0.736 0.016 2 0.830
MAP2K6_TYRMAP2K6_TYR 0.736 0.009 -1 0.811
EPHB4EPHB4 0.736 0.099 -1 0.818
MAP2K4_TYRMAP2K4_TYR 0.735 -0.069 -1 0.813
NEK3NEK3 0.735 -0.217 1 0.645
BIKEBIKE 0.735 -0.041 1 0.590
TESK1_TYRTESK1_TYR 0.735 -0.083 3 0.810
PDHK1_TYRPDHK1_TYR 0.734 0.007 -1 0.826
MAP2K7_TYRMAP2K7_TYR 0.734 -0.153 2 0.817
MYO3AMYO3A 0.733 -0.059 1 0.679
PKMYT1_TYRPKMYT1_TYR 0.733 -0.092 3 0.785
MYO3BMYO3B 0.731 -0.098 2 0.777
PINK1_TYRPINK1_TYR 0.731 -0.121 1 0.724
SRMSSRMS 0.731 0.136 1 0.814
YES1YES1 0.730 0.075 -1 0.814
EPHB2EPHB2 0.729 0.122 -1 0.808
YANK3YANK3 0.729 -0.095 2 0.357
TAO1TAO1 0.729 -0.128 1 0.630
EPHA4EPHA4 0.729 0.078 2 0.727
RETRET 0.729 -0.065 1 0.693
FERFER 0.728 0.049 1 0.808
EPHB1EPHB1 0.728 0.073 1 0.808
CK1ACK1A 0.728 -0.072 -3 0.368
LIMK2_TYRLIMK2_TYR 0.727 -0.091 -3 0.761
TYRO3TYRO3 0.727 -0.037 3 0.717
LCKLCK 0.727 0.120 -1 0.819
BLKBLK 0.726 0.134 -1 0.819
INSRRINSRR 0.725 0.024 3 0.691
ABL2ABL2 0.725 0.020 -1 0.776
CSF1RCSF1R 0.725 -0.022 3 0.726
ROS1ROS1 0.725 -0.062 3 0.692
FYNFYN 0.724 0.149 -1 0.802
ITKITK 0.724 0.056 -1 0.784
EPHB3EPHB3 0.724 0.044 -1 0.811
DDR1DDR1 0.724 -0.117 4 0.785
HCKHCK 0.724 0.045 -1 0.811
TYK2TYK2 0.723 -0.150 1 0.694
MST1RMST1R 0.723 -0.124 3 0.740
TECTEC 0.723 0.081 -1 0.736
EPHA7EPHA7 0.722 0.074 2 0.726
MERTKMERTK 0.722 0.031 3 0.719
LIMK1_TYRLIMK1_TYR 0.722 -0.195 2 0.813
JAK2JAK2 0.721 -0.133 1 0.694
JAK3JAK3 0.721 -0.062 1 0.684
ABL1ABL1 0.721 -0.002 -1 0.774
STLK3STLK3 0.720 -0.179 1 0.673
FLT3FLT3 0.719 -0.039 3 0.715
BMXBMX 0.719 0.032 -1 0.711
TNK2TNK2 0.718 -0.069 3 0.717
AXLAXL 0.718 -0.037 3 0.721
KITKIT 0.718 -0.053 3 0.734
FGRFGR 0.717 -0.092 1 0.733
FGFR2FGFR2 0.717 -0.079 3 0.746
PDGFRBPDGFRB 0.717 -0.097 3 0.733
FRKFRK 0.716 0.054 -1 0.816
EPHA5EPHA5 0.715 0.076 2 0.720
KDRKDR 0.715 -0.061 3 0.696
AAK1AAK1 0.715 -0.026 1 0.486
TEKTEK 0.715 -0.078 3 0.674
PTK2BPTK2B 0.715 0.061 -1 0.777
ALKALK 0.715 -0.031 3 0.661
PTK6PTK6 0.715 -0.052 -1 0.711
EPHA3EPHA3 0.714 -0.034 2 0.710
BTKBTK 0.714 -0.049 -1 0.748
LTKLTK 0.714 -0.036 3 0.682
EPHA1EPHA1 0.713 -0.012 3 0.697
LYNLYN 0.713 0.051 3 0.661
EPHA8EPHA8 0.712 0.056 -1 0.799
FGFR1FGFR1 0.712 -0.112 3 0.712
METMET 0.712 -0.045 3 0.720
JAK1JAK1 0.712 -0.082 1 0.653
PTK2PTK2 0.710 0.101 -1 0.778
NEK10_TYRNEK10_TYR 0.709 -0.152 1 0.573
SYKSYK 0.709 0.115 -1 0.742
TNK1TNK1 0.709 -0.148 3 0.697
CK1G3CK1G3 0.709 -0.083 -3 0.327
NTRK1NTRK1 0.709 -0.109 -1 0.772
SRCSRC 0.709 0.043 -1 0.796
FLT1FLT1 0.708 -0.061 -1 0.788
PDGFRAPDGFRA 0.708 -0.172 3 0.731
ERBB2ERBB2 0.708 -0.090 1 0.677
FGFR3FGFR3 0.708 -0.078 3 0.720
WEE1_TYRWEE1_TYR 0.706 -0.102 -1 0.714
NTRK2NTRK2 0.706 -0.119 3 0.711
EGFREGFR 0.706 -0.014 1 0.603
TNNI3K_TYRTNNI3K_TYR 0.706 -0.132 1 0.694
INSRINSR 0.705 -0.096 3 0.661
FLT4FLT4 0.703 -0.132 3 0.700
CSKCSK 0.703 -0.030 2 0.732
DDR2DDR2 0.702 -0.086 3 0.693
EPHA2EPHA2 0.701 0.021 -1 0.760
MATKMATK 0.701 -0.073 -1 0.698
NTRK3NTRK3 0.700 -0.109 -1 0.725
FGFR4FGFR4 0.699 -0.047 -1 0.731
YANK2YANK2 0.697 -0.113 2 0.373
ERBB4ERBB4 0.697 -0.001 1 0.655
IGF1RIGF1R 0.693 -0.082 3 0.610
FESFES 0.688 -0.027 -1 0.694
CK1G2CK1G2 0.686 -0.092 -3 0.419
MUSKMUSK 0.685 -0.144 1 0.566
ZAP70ZAP70 0.672 -0.050 -1 0.670