Motif 672 (n=126)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKD9 | CCDC85C | S372 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| O00151 | PDLIM1 | S186 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14646 | CHD1 | S215 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14776 | TCERG1 | S638 | ochoa | Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}. |
| O14929 | HAT1 | S190 | psp | Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) | Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}. |
| O15355 | PPM1G | S517 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43164 | PJA2 | S428 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43493 | TGOLN2 | S351 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43719 | HTATSF1 | S557 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43896 | KIF1C | S676 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60296 | TRAK2 | S460 | ochoa | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}. |
| O60841 | EIF5B | S295 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75157 | TSC22D2 | S45 | ochoa | TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) | Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. {ECO:0000269|PubMed:27573352}. |
| O75264 | SMIM24 | S108 | ochoa | Small integral membrane protein 24 | None |
| O75362 | ZNF217 | S328 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75391 | SPAG7 | S94 | ochoa | Sperm-associated antigen 7 | None |
| O75691 | UTP20 | S783 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95400 | CD2BP2 | S60 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| O95714 | HERC2 | S1938 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P08670 | VIM | S214 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P10451 | SPP1 | S81 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S270 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12259 | F5 | S1533 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P16157 | ANK1 | S1607 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P18583 | SON | S278 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P21127 | CDK11B | S47 | ochoa|psp | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P22314 | UBA1 | S820 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P29466 | CASP1 | S376 | psp | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] | Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:26375003, PubMed:32051255, PubMed:37993714, PubMed:7876192, PubMed:9334240). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:32051255, PubMed:7876192). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:15498465, PubMed:1574116, PubMed:7876192). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32051255, PubMed:32109412, PubMed:32553275). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:22464733). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547). {ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7876192, ECO:0000269|PubMed:9334240}.; FUNCTION: [Isoform Delta]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.; FUNCTION: [Isoform Epsilon]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}. |
| P31629 | HIVEP2 | S950 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33981 | TTK | S362 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35269 | GTF2F1 | S341 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P45973 | CBX5 | S45 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46013 | MKI67 | S264 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S634 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46199 | MTIF2 | S426 | ochoa | Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt)) | One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. |
| P49588 | AARS1 | S554 | ochoa | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P50502 | ST13 | S75 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P54132 | BLM | S349 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54252 | ATXN3 | S236 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P58317 | ZNF121 | S87 | ochoa | Zinc finger protein 121 (Zinc finger protein 20) | May be involved in transcriptional regulation. |
| Q01082 | SPTBN1 | S2128 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01105 | SET | S63 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01484 | ANK2 | S3764 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02952 | AKAP12 | S1674 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03135 | CAV1 | S37 | ochoa | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q05682 | CALD1 | S234 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q08211 | DHX9 | S1025 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12872 | SFSWAP | S279 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13007 | IL24 | S88 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13873 | BMPR2 | S680 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14151 | SAFB2 | S283 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14191 | WRN | S440 | ochoa|psp | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q15003 | NCAPH | S233 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15057 | ACAP2 | S517 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15121 | PEA15 | S61 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q15185 | PTGES3 | S118 | ochoa|psp | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15424 | SAFB | S284 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q2LD37 | BLTP1 | S3562 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q32MZ4 | LRRFIP1 | S300 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q6P0N0 | MIS18BP1 | S131 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PCB5 | RSBN1L | S41 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6UWZ7 | ABRAXAS1 | S386 | ochoa | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}. |
| Q6UX04 | CWC27 | S299 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6UX73 | C16orf89 | S173 | ochoa | UPF0764 protein C16orf89 | None |
| Q6UXH1 | CRELD2 | S70 | ochoa | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q6ZS30 | NBEAL1 | S1841 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q7Z3B3 | KANSL1 | S901 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z3K6 | MIER3 | S52 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q8IZP2 | ST13P4 | S71 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8N392 | ARHGAP18 | S74 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N554 | ZNF276 | S378 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8NEL9 | DDHD1 | S240 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NEZ4 | KMT2C | S1225 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NF91 | SYNE1 | S8325 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S2862 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TBA6 | GOLGA5 | S189 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TBA6 | GOLGA5 | S460 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TD26 | CHD6 | S1359 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TDJ6 | DMXL2 | S2123 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEQ6 | GEMIN5 | S1322 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WVC0 | LEO1 | S273 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WWK9 | CKAP2 | S650 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q92539 | LPIN2 | S303 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92558 | WASF1 | S104 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
| Q96DT7 | ZBTB10 | S628 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96IQ7 | VSIG2 | S293 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96JZ2 | HSH2D | S318 | psp | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96K76 | USP47 | S899 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96RL1 | UIMC1 | S452 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RT1 | ERBIN | S598 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99590 | SCAF11 | S449 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BTC0 | DIDO1 | S898 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BW71 | HIRIP3 | S359 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXL6 | CARD14 | S241 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9C0D6 | FHDC1 | S498 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H1E3 | NUCKS1 | S75 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H246 | C1orf21 | S95 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
| Q9H4L7 | SMARCAD1 | S124 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H9B1 | EHMT1 | S649 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9HC77 | CPAP | S764 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCY8 | S100A14 | S83 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9P0V9 | SEPTIN10 | S24 | ochoa | Septin-10 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}. |
| Q9P2D1 | CHD7 | T2952 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBW5 | BIN2 | S90 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UDY2 | TJP2 | S394 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHB7 | AFF4 | S388 | psp | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJC3 | HOOK1 | S450 | ochoa | Protein Hook homolog 1 (h-hook1) (hHK1) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9ULW0 | TPX2 | S101 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULW0 | TPX2 | S209 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UQ88 | CDK11A | S47 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y282 | ERGIC3 | S116 | ochoa | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) | Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}. |
| Q9Y2L1 | DIS3 | S215 | ochoa | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}. |
| Q9Y3B9 | RRP15 | S258 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y3T9 | NOC2L | S672 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4C8 | RBM19 | S180 | ochoa | Probable RNA-binding protein 19 (RNA-binding motif protein 19) | Plays a role in embryo pre-implantation development. {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S371 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5B6 | PAXBP1 | S154 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5T5 | USP16 | S524 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y6W5 | WASF2 | S103 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q9NTJ3 | SMC4 | S964 | Sugiyama | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| O60566 | BUB1B | S411 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P23443 | RPS6KB1 | S375 | Sugiyama | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P18754 | RCC1 | S125 | Sugiyama | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| Q6ULP2 | AFTPH | S508 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| P49917 | LIG4 | S672 | SIGNOR | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:12517771, PubMed:17290226, PubMed:23523427, PubMed:29980672, PubMed:33586762, PubMed:8798671, PubMed:9242410, PubMed:9809069). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226). Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069). Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421). LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242). {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:23523427, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:29980672, ECO:0000269|PubMed:33586762, ECO:0000269|PubMed:8798671, ECO:0000269|PubMed:9242410, ECO:0000269|PubMed:9809069}. |
| Q8N4X5 | AFAP1L2 | S711 | Sugiyama | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000013 | 4.876 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000480 | 3.319 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.000709 | 3.149 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.001019 | 2.992 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.001384 | 2.859 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.001669 | 2.778 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.002022 | 2.694 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.002880 | 2.541 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.003488 | 2.457 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.003350 | 2.475 |
| R-HSA-5689877 | Josephin domain DUBs | 0.005568 | 2.254 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.004531 | 2.344 |
| R-HSA-5693538 | Homology Directed Repair | 0.005494 | 2.260 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.007332 | 2.135 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.007206 | 2.142 |
| R-HSA-8939211 | ESR-mediated signaling | 0.006459 | 2.190 |
| R-HSA-69481 | G2/M Checkpoints | 0.007408 | 2.130 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.016750 | 1.776 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.016750 | 1.776 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.016750 | 1.776 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.016750 | 1.776 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.016750 | 1.776 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.033222 | 1.479 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.033222 | 1.479 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.033222 | 1.479 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.033222 | 1.479 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.033222 | 1.479 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.033222 | 1.479 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.033222 | 1.479 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.033222 | 1.479 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.033222 | 1.479 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.033222 | 1.479 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.033222 | 1.479 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.017868 | 1.748 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.019283 | 1.715 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.019283 | 1.715 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.019283 | 1.715 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.019283 | 1.715 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.028696 | 1.542 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.014688 | 1.833 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.015342 | 1.814 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.031843 | 1.497 |
| R-HSA-380287 | Centrosome maturation | 0.033852 | 1.470 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.032840 | 1.484 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.019605 | 1.708 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.026206 | 1.582 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.032167 | 1.493 |
| R-HSA-73886 | Chromosome Maintenance | 0.028193 | 1.550 |
| R-HSA-844615 | The AIM2 inflammasome | 0.033222 | 1.479 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.008920 | 2.050 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.030412 | 1.517 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.028951 | 1.538 |
| R-HSA-69275 | G2/M Transition | 0.030690 | 1.513 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.031798 | 1.498 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.031318 | 1.504 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.011369 | 1.944 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.012683 | 1.897 |
| R-HSA-5688426 | Deubiquitination | 0.029938 | 1.524 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.022247 | 1.653 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.018080 | 1.743 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.022706 | 1.644 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.035273 | 1.453 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.035794 | 1.446 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.035794 | 1.446 |
| R-HSA-72172 | mRNA Splicing | 0.042233 | 1.374 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.043491 | 1.362 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.043491 | 1.362 |
| R-HSA-844623 | The IPAF inflammasome | 0.041355 | 1.383 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.041513 | 1.382 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.044683 | 1.350 |
| R-HSA-1500620 | Meiosis | 0.044857 | 1.348 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.045504 | 1.342 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.057418 | 1.241 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.057418 | 1.241 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.047550 | 1.323 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.047550 | 1.323 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.052071 | 1.283 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.056059 | 1.251 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.049629 | 1.304 |
| R-HSA-68886 | M Phase | 0.055753 | 1.254 |
| R-HSA-447038 | NrCAM interactions | 0.057418 | 1.241 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.058846 | 1.230 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.062763 | 1.202 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.062859 | 1.202 |
| R-HSA-157579 | Telomere Maintenance | 0.064256 | 1.192 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.065055 | 1.187 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.065349 | 1.185 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.065667 | 1.183 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.067092 | 1.173 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.081012 | 1.091 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.076921 | 1.114 |
| R-HSA-447043 | Neurofascin interactions | 0.073213 | 1.135 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.071751 | 1.144 |
| R-HSA-447041 | CHL1 interactions | 0.081012 | 1.091 |
| R-HSA-9675135 | Diseases of DNA repair | 0.076921 | 1.114 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.088746 | 1.052 |
| R-HSA-597592 | Post-translational protein modification | 0.073039 | 1.136 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.093402 | 1.030 |
| R-HSA-75153 | Apoptotic execution phase | 0.076921 | 1.114 |
| R-HSA-1221632 | Meiotic synapsis | 0.094559 | 1.024 |
| R-HSA-448706 | Interleukin-1 processing | 0.096415 | 1.016 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.096415 | 1.016 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.096415 | 1.016 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.096742 | 1.014 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.162617 | 0.789 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.183596 | 0.736 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.197292 | 0.705 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.210759 | 0.676 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.217408 | 0.663 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.217408 | 0.663 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.243454 | 0.614 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.243454 | 0.614 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.249830 | 0.602 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.249830 | 0.602 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.249830 | 0.602 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.249830 | 0.602 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.256152 | 0.592 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.129902 | 0.886 |
| R-HSA-390522 | Striated Muscle Contraction | 0.286980 | 0.542 |
| R-HSA-72086 | mRNA Capping | 0.256152 | 0.592 |
| R-HSA-164843 | 2-LTR circle formation | 0.104020 | 0.983 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.162617 | 0.789 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.252359 | 0.598 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.210759 | 0.676 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.237024 | 0.625 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.132736 | 0.877 |
| R-HSA-209968 | Thyroxine biosynthesis | 0.256152 | 0.592 |
| R-HSA-9930044 | Nuclear RNA decay | 0.280917 | 0.551 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.126456 | 0.898 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.176662 | 0.753 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.183596 | 0.736 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.243454 | 0.614 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.110337 | 0.957 |
| R-HSA-68877 | Mitotic Prometaphase | 0.105898 | 0.975 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.176662 | 0.753 |
| R-HSA-201451 | Signaling by BMP | 0.243454 | 0.614 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.176662 | 0.753 |
| R-HSA-162587 | HIV Life Cycle | 0.184932 | 0.733 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.262422 | 0.581 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.274804 | 0.561 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.183596 | 0.736 |
| R-HSA-8852135 | Protein ubiquitination | 0.155878 | 0.807 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.224002 | 0.650 |
| R-HSA-68875 | Mitotic Prophase | 0.105300 | 0.978 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.118304 | 0.927 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.176662 | 0.753 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.148335 | 0.829 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.148335 | 0.829 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.169669 | 0.770 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.147108 | 0.832 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.190473 | 0.720 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.280917 | 0.551 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.256152 | 0.592 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.262422 | 0.581 |
| R-HSA-203615 | eNOS activation | 0.292991 | 0.533 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.148335 | 0.829 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.155506 | 0.808 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.147108 | 0.832 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.217408 | 0.663 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.148335 | 0.829 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.210759 | 0.676 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.268639 | 0.571 |
| R-HSA-373760 | L1CAM interactions | 0.098430 | 1.007 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.269215 | 0.570 |
| R-HSA-73894 | DNA Repair | 0.104015 | 0.983 |
| R-HSA-162592 | Integration of provirus | 0.119040 | 0.924 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.148335 | 0.829 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.243454 | 0.614 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.243454 | 0.614 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.249830 | 0.602 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.262422 | 0.581 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.292991 | 0.533 |
| R-HSA-3214847 | HATs acetylate histones | 0.238061 | 0.623 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.292991 | 0.533 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.282410 | 0.549 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.247395 | 0.607 |
| R-HSA-1483213 | Synthesis of PE | 0.243454 | 0.614 |
| R-HSA-622312 | Inflammasomes | 0.249830 | 0.602 |
| R-HSA-74160 | Gene expression (Transcription) | 0.113103 | 0.947 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.152943 | 0.815 |
| R-HSA-2028269 | Signaling by Hippo | 0.169669 | 0.770 |
| R-HSA-210991 | Basigin interactions | 0.197292 | 0.705 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.237024 | 0.625 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.237024 | 0.625 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.176662 | 0.753 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.183596 | 0.736 |
| R-HSA-1474165 | Reproduction | 0.126983 | 0.896 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.133426 | 0.875 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.176662 | 0.753 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.204054 | 0.690 |
| R-HSA-8979227 | Triglyceride metabolism | 0.110500 | 0.957 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.168661 | 0.773 |
| R-HSA-373753 | Nephrin family interactions | 0.190473 | 0.720 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.210759 | 0.676 |
| R-HSA-180786 | Extension of Telomeres | 0.110500 | 0.957 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.286980 | 0.542 |
| R-HSA-4839726 | Chromatin organization | 0.193713 | 0.713 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.183596 | 0.736 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.292991 | 0.533 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.197292 | 0.705 |
| R-HSA-194138 | Signaling by VEGF | 0.115948 | 0.936 |
| R-HSA-212436 | Generic Transcription Pathway | 0.174765 | 0.758 |
| R-HSA-5620971 | Pyroptosis | 0.249830 | 0.602 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.262978 | 0.580 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.155878 | 0.807 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.280917 | 0.551 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.231848 | 0.635 |
| R-HSA-5357801 | Programmed Cell Death | 0.296157 | 0.528 |
| R-HSA-8953854 | Metabolism of RNA | 0.298380 | 0.525 |
| R-HSA-381042 | PERK regulates gene expression | 0.298953 | 0.524 |
| R-HSA-3371511 | HSF1 activation | 0.304864 | 0.516 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.304864 | 0.516 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.304864 | 0.516 |
| R-HSA-163560 | Triglyceride catabolism | 0.304864 | 0.516 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.304864 | 0.516 |
| R-HSA-392499 | Metabolism of proteins | 0.310289 | 0.508 |
| R-HSA-3371556 | Cellular response to heat stress | 0.315859 | 0.501 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.316539 | 0.500 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.316539 | 0.500 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.322303 | 0.492 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.328019 | 0.484 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.328019 | 0.484 |
| R-HSA-167169 | HIV Transcription Elongation | 0.328019 | 0.484 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.328019 | 0.484 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.328019 | 0.484 |
| R-HSA-3371568 | Attenuation phase | 0.328019 | 0.484 |
| R-HSA-9646399 | Aggrephagy | 0.328019 | 0.484 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.328019 | 0.484 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.333687 | 0.477 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.333687 | 0.477 |
| R-HSA-199991 | Membrane Trafficking | 0.336478 | 0.473 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.339308 | 0.469 |
| R-HSA-167161 | HIV Transcription Initiation | 0.339308 | 0.469 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.339308 | 0.469 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.339308 | 0.469 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.339308 | 0.469 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.339308 | 0.469 |
| R-HSA-165159 | MTOR signalling | 0.344881 | 0.462 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.344881 | 0.462 |
| R-HSA-162906 | HIV Infection | 0.346782 | 0.460 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.350408 | 0.455 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.361323 | 0.442 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.361323 | 0.442 |
| R-HSA-774815 | Nucleosome assembly | 0.361323 | 0.442 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.366712 | 0.436 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.366712 | 0.436 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.366712 | 0.436 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.372056 | 0.429 |
| R-HSA-1483191 | Synthesis of PC | 0.372056 | 0.429 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.379915 | 0.420 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.382909 | 0.417 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.382909 | 0.417 |
| R-HSA-9664407 | Parasite infection | 0.382909 | 0.417 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.385897 | 0.414 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.387821 | 0.411 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.387821 | 0.411 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.391853 | 0.407 |
| R-HSA-912446 | Meiotic recombination | 0.392988 | 0.406 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.392988 | 0.406 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.398112 | 0.400 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.398112 | 0.400 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.398112 | 0.400 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.403193 | 0.394 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.403193 | 0.394 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.403193 | 0.394 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.408232 | 0.389 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.413228 | 0.384 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.418182 | 0.379 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.418182 | 0.379 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.418182 | 0.379 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.423095 | 0.374 |
| R-HSA-1483166 | Synthesis of PA | 0.423095 | 0.374 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.423095 | 0.374 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.427966 | 0.369 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.432797 | 0.364 |
| R-HSA-191859 | snRNP Assembly | 0.432797 | 0.364 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.432797 | 0.364 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.437587 | 0.359 |
| R-HSA-983189 | Kinesins | 0.437587 | 0.359 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.437587 | 0.359 |
| R-HSA-379724 | tRNA Aminoacylation | 0.437587 | 0.359 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.442337 | 0.354 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.445411 | 0.351 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.447047 | 0.350 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.447047 | 0.350 |
| R-HSA-186797 | Signaling by PDGF | 0.447047 | 0.350 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.447222 | 0.349 |
| R-HSA-109581 | Apoptosis | 0.449889 | 0.347 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.451718 | 0.345 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.451718 | 0.345 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.451718 | 0.345 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.456350 | 0.341 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.465497 | 0.332 |
| R-HSA-9658195 | Leishmania infection | 0.468248 | 0.330 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.468248 | 0.330 |
| R-HSA-167172 | Transcription of the HIV genome | 0.474491 | 0.324 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.474491 | 0.324 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.474491 | 0.324 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.474491 | 0.324 |
| R-HSA-5218859 | Regulated Necrosis | 0.474491 | 0.324 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.474671 | 0.324 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.474987 | 0.323 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.483200 | 0.316 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.483335 | 0.316 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.483335 | 0.316 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.483335 | 0.316 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.485920 | 0.313 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.487701 | 0.312 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.487701 | 0.312 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.488632 | 0.311 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.488632 | 0.311 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.492031 | 0.308 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.510002 | 0.292 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.516599 | 0.287 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.517257 | 0.286 |
| R-HSA-216083 | Integrin cell surface interactions | 0.517257 | 0.286 |
| R-HSA-9659379 | Sensory processing of sound | 0.521339 | 0.283 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.523061 | 0.281 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.525386 | 0.280 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.525386 | 0.280 |
| R-HSA-9833482 | PKR-mediated signaling | 0.525386 | 0.280 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.533341 | 0.273 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.533379 | 0.273 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.541239 | 0.267 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.548967 | 0.260 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.548967 | 0.260 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.552783 | 0.257 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.552783 | 0.257 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.554457 | 0.256 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.560318 | 0.252 |
| R-HSA-9663891 | Selective autophagy | 0.560318 | 0.252 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.560831 | 0.251 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.567727 | 0.246 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.575012 | 0.240 |
| R-HSA-397014 | Muscle contraction | 0.584812 | 0.233 |
| R-HSA-68882 | Mitotic Anaphase | 0.594133 | 0.226 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.596145 | 0.225 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.596439 | 0.224 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.602954 | 0.220 |
| R-HSA-190236 | Signaling by FGFR | 0.602954 | 0.220 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.609650 | 0.215 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.612955 | 0.213 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.616233 | 0.210 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.621163 | 0.207 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.622707 | 0.206 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.625903 | 0.203 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.625903 | 0.203 |
| R-HSA-72312 | rRNA processing | 0.629862 | 0.201 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.638420 | 0.195 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.641483 | 0.193 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.656420 | 0.183 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.667923 | 0.175 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.667923 | 0.175 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.681765 | 0.166 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.681765 | 0.166 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.689794 | 0.161 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.692096 | 0.160 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.695035 | 0.158 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.695035 | 0.158 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.695035 | 0.158 |
| R-HSA-114608 | Platelet degranulation | 0.700188 | 0.155 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.715133 | 0.146 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.715133 | 0.146 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.717551 | 0.144 |
| R-HSA-9679506 | SARS-CoV Infections | 0.720487 | 0.142 |
| R-HSA-5368287 | Mitochondrial translation | 0.731637 | 0.136 |
| R-HSA-72766 | Translation | 0.735304 | 0.134 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.737471 | 0.132 |
| R-HSA-1632852 | Macroautophagy | 0.738416 | 0.132 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.745025 | 0.128 |
| R-HSA-1483257 | Phospholipid metabolism | 0.747104 | 0.127 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.748680 | 0.126 |
| R-HSA-195721 | Signaling by WNT | 0.751807 | 0.124 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.759809 | 0.119 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.761850 | 0.118 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.763874 | 0.117 |
| R-HSA-2142753 | Arachidonate metabolism | 0.763874 | 0.117 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.767871 | 0.115 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.769844 | 0.114 |
| R-HSA-9612973 | Autophagy | 0.771801 | 0.112 |
| R-HSA-1500931 | Cell-Cell communication | 0.778479 | 0.109 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.779464 | 0.108 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.786871 | 0.104 |
| R-HSA-449147 | Signaling by Interleukins | 0.799038 | 0.097 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.802646 | 0.095 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.804326 | 0.095 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.804326 | 0.095 |
| R-HSA-168255 | Influenza Infection | 0.814110 | 0.089 |
| R-HSA-2559583 | Cellular Senescence | 0.815693 | 0.088 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.818601 | 0.087 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.820954 | 0.086 |
| R-HSA-162582 | Signal Transduction | 0.823222 | 0.084 |
| R-HSA-5617833 | Cilium Assembly | 0.830803 | 0.081 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.839272 | 0.076 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.844683 | 0.073 |
| R-HSA-428157 | Sphingolipid metabolism | 0.846007 | 0.073 |
| R-HSA-9824446 | Viral Infection Pathways | 0.859052 | 0.066 |
| R-HSA-422475 | Axon guidance | 0.860307 | 0.065 |
| R-HSA-418990 | Adherens junctions interactions | 0.868014 | 0.061 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.869499 | 0.061 |
| R-HSA-8951664 | Neddylation | 0.871366 | 0.060 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.876765 | 0.057 |
| R-HSA-2262752 | Cellular responses to stress | 0.878259 | 0.056 |
| R-HSA-9675108 | Nervous system development | 0.887590 | 0.052 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.887863 | 0.052 |
| R-HSA-421270 | Cell-cell junction organization | 0.900564 | 0.045 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.904745 | 0.043 |
| R-HSA-109582 | Hemostasis | 0.912708 | 0.040 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.914081 | 0.039 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.918403 | 0.037 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.921163 | 0.036 |
| R-HSA-446728 | Cell junction organization | 0.921163 | 0.036 |
| R-HSA-168249 | Innate Immune System | 0.944201 | 0.025 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.945101 | 0.025 |
| R-HSA-1474244 | Extracellular matrix organization | 0.950073 | 0.022 |
| R-HSA-1280218 | Adaptive Immune System | 0.950982 | 0.022 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.958061 | 0.019 |
| R-HSA-5663205 | Infectious disease | 0.959116 | 0.018 |
| R-HSA-913531 | Interferon Signaling | 0.968431 | 0.014 |
| R-HSA-8978868 | Fatty acid metabolism | 0.974361 | 0.011 |
| R-HSA-1643685 | Disease | 0.977985 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 0.983396 | 0.007 |
| R-HSA-168256 | Immune System | 0.984562 | 0.007 |
| R-HSA-211859 | Biological oxidations | 0.990663 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995941 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.996721 | 0.001 |
| R-HSA-1266738 | Developmental Biology | 0.999495 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999984 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.851 | 0.554 | 2 | 0.841 |
CDC7 |
0.830 | 0.195 | 1 | 0.866 |
COT |
0.829 | 0.150 | 2 | 0.697 |
CAMK2B |
0.825 | 0.306 | 2 | 0.750 |
CAMK2G |
0.823 | 0.211 | 2 | 0.717 |
BMPR1B |
0.819 | 0.312 | 1 | 0.889 |
PIM3 |
0.819 | 0.094 | -3 | 0.702 |
GRK6 |
0.819 | 0.310 | 1 | 0.845 |
CK2A2 |
0.818 | 0.420 | 1 | 0.764 |
DSTYK |
0.817 | 0.100 | 2 | 0.728 |
NDR2 |
0.817 | 0.064 | -3 | 0.706 |
TGFBR1 |
0.817 | 0.270 | -2 | 0.819 |
CLK3 |
0.817 | 0.132 | 1 | 0.735 |
MOS |
0.816 | 0.137 | 1 | 0.837 |
RSK2 |
0.816 | 0.098 | -3 | 0.653 |
CAMK2A |
0.816 | 0.218 | 2 | 0.712 |
GRK1 |
0.816 | 0.212 | -2 | 0.746 |
CAMK2D |
0.814 | 0.148 | -3 | 0.722 |
MAPKAPK2 |
0.813 | 0.119 | -3 | 0.598 |
IKKA |
0.812 | 0.116 | -2 | 0.703 |
PRPK |
0.812 | -0.015 | -1 | 0.819 |
LATS2 |
0.811 | 0.078 | -5 | 0.735 |
ALK2 |
0.811 | 0.295 | -2 | 0.817 |
BMPR1A |
0.810 | 0.298 | 1 | 0.872 |
IKKB |
0.810 | 0.007 | -2 | 0.715 |
CAMK1B |
0.809 | 0.022 | -3 | 0.753 |
PLK3 |
0.808 | 0.193 | 2 | 0.627 |
GCN2 |
0.808 | -0.134 | 2 | 0.620 |
CK2A1 |
0.808 | 0.398 | 1 | 0.750 |
PIM1 |
0.808 | 0.087 | -3 | 0.639 |
PRKD1 |
0.807 | 0.011 | -3 | 0.702 |
PDHK4 |
0.807 | -0.050 | 1 | 0.774 |
P90RSK |
0.807 | 0.038 | -3 | 0.662 |
TBK1 |
0.807 | -0.059 | 1 | 0.677 |
GRK5 |
0.807 | 0.094 | -3 | 0.742 |
MARK4 |
0.806 | 0.043 | 4 | 0.834 |
LATS1 |
0.806 | 0.208 | -3 | 0.737 |
RAF1 |
0.806 | -0.076 | 1 | 0.796 |
ULK2 |
0.806 | -0.125 | 2 | 0.601 |
GRK7 |
0.805 | 0.237 | 1 | 0.770 |
BMPR2 |
0.805 | -0.029 | -2 | 0.860 |
ALK4 |
0.805 | 0.171 | -2 | 0.838 |
TGFBR2 |
0.804 | -0.013 | -2 | 0.806 |
SKMLCK |
0.804 | 0.073 | -2 | 0.825 |
PLK1 |
0.804 | 0.151 | -2 | 0.804 |
RSK4 |
0.804 | 0.100 | -3 | 0.613 |
PKN3 |
0.803 | -0.022 | -3 | 0.712 |
HUNK |
0.803 | -0.030 | 2 | 0.600 |
IKKE |
0.802 | -0.076 | 1 | 0.670 |
NDR1 |
0.802 | -0.015 | -3 | 0.706 |
AMPKA1 |
0.802 | 0.004 | -3 | 0.725 |
NEK6 |
0.801 | -0.077 | -2 | 0.832 |
MTOR |
0.801 | -0.128 | 1 | 0.708 |
TSSK2 |
0.801 | 0.037 | -5 | 0.763 |
ERK5 |
0.801 | -0.023 | 1 | 0.724 |
ACVR2A |
0.801 | 0.190 | -2 | 0.795 |
MAPKAPK3 |
0.800 | 0.009 | -3 | 0.648 |
ACVR2B |
0.800 | 0.195 | -2 | 0.799 |
ULK1 |
0.800 | -0.097 | -3 | 0.762 |
GRK4 |
0.800 | 0.044 | -2 | 0.783 |
ATR |
0.800 | -0.041 | 1 | 0.734 |
PDHK1 |
0.800 | -0.140 | 1 | 0.748 |
PRKD2 |
0.799 | -0.006 | -3 | 0.655 |
RSK3 |
0.799 | -0.007 | -3 | 0.654 |
ATM |
0.799 | 0.053 | 1 | 0.694 |
AMPKA2 |
0.797 | -0.005 | -3 | 0.689 |
NLK |
0.797 | -0.107 | 1 | 0.714 |
WNK1 |
0.797 | -0.060 | -2 | 0.840 |
TSSK1 |
0.796 | -0.002 | -3 | 0.752 |
NEK7 |
0.796 | -0.156 | -3 | 0.744 |
CAMLCK |
0.796 | -0.021 | -2 | 0.819 |
NIK |
0.796 | -0.086 | -3 | 0.773 |
NUAK2 |
0.796 | -0.047 | -3 | 0.712 |
P70S6KB |
0.796 | 0.001 | -3 | 0.674 |
CDKL1 |
0.796 | -0.058 | -3 | 0.678 |
DAPK2 |
0.795 | -0.015 | -3 | 0.754 |
MST4 |
0.795 | -0.048 | 2 | 0.680 |
BCKDK |
0.795 | -0.079 | -1 | 0.747 |
PKCD |
0.794 | -0.038 | 2 | 0.614 |
RIPK3 |
0.794 | -0.123 | 3 | 0.593 |
BRSK1 |
0.794 | 0.020 | -3 | 0.668 |
MSK1 |
0.794 | 0.054 | -3 | 0.604 |
AURC |
0.793 | 0.025 | -2 | 0.653 |
PKACG |
0.793 | 0.002 | -2 | 0.722 |
DNAPK |
0.791 | 0.075 | 1 | 0.613 |
MLK1 |
0.791 | -0.155 | 2 | 0.630 |
MSK2 |
0.790 | -0.012 | -3 | 0.596 |
SRPK1 |
0.790 | -0.024 | -3 | 0.624 |
PRKX |
0.789 | 0.091 | -3 | 0.535 |
CDKL5 |
0.789 | -0.059 | -3 | 0.670 |
MARK2 |
0.789 | 0.041 | 4 | 0.750 |
MARK3 |
0.789 | 0.043 | 4 | 0.783 |
DLK |
0.789 | -0.082 | 1 | 0.788 |
ICK |
0.788 | -0.058 | -3 | 0.714 |
CHK1 |
0.788 | 0.002 | -3 | 0.720 |
PKACB |
0.788 | 0.043 | -2 | 0.669 |
NEK9 |
0.787 | -0.197 | 2 | 0.639 |
PLK2 |
0.787 | 0.156 | -3 | 0.780 |
PAK1 |
0.787 | -0.024 | -2 | 0.748 |
CLK2 |
0.787 | 0.078 | -3 | 0.629 |
WNK3 |
0.787 | -0.227 | 1 | 0.741 |
CHAK2 |
0.787 | -0.114 | -1 | 0.841 |
NIM1 |
0.787 | -0.111 | 3 | 0.669 |
MASTL |
0.786 | -0.221 | -2 | 0.770 |
CAMK4 |
0.786 | -0.081 | -3 | 0.690 |
QSK |
0.786 | -0.025 | 4 | 0.808 |
HIPK4 |
0.786 | -0.085 | 1 | 0.655 |
PKN2 |
0.785 | -0.103 | -3 | 0.703 |
MARK1 |
0.785 | 0.033 | 4 | 0.799 |
NUAK1 |
0.785 | -0.070 | -3 | 0.676 |
GRK2 |
0.785 | 0.079 | -2 | 0.675 |
ANKRD3 |
0.785 | -0.166 | 1 | 0.785 |
TTBK2 |
0.785 | -0.146 | 2 | 0.514 |
MELK |
0.785 | -0.080 | -3 | 0.684 |
PKR |
0.784 | -0.062 | 1 | 0.754 |
DRAK1 |
0.784 | 0.058 | 1 | 0.826 |
CDK8 |
0.784 | -0.067 | 1 | 0.530 |
GSK3A |
0.784 | 0.167 | 4 | 0.615 |
MLK2 |
0.783 | -0.193 | 2 | 0.639 |
SRPK2 |
0.783 | -0.030 | -3 | 0.547 |
AURB |
0.783 | -0.006 | -2 | 0.645 |
MLK3 |
0.783 | -0.096 | 2 | 0.571 |
AURA |
0.783 | 0.022 | -2 | 0.615 |
TLK2 |
0.782 | -0.027 | 1 | 0.711 |
MNK2 |
0.782 | -0.048 | -2 | 0.773 |
BRAF |
0.782 | 0.022 | -4 | 0.828 |
BRSK2 |
0.782 | -0.075 | -3 | 0.698 |
KIS |
0.782 | -0.062 | 1 | 0.559 |
MYLK4 |
0.781 | -0.005 | -2 | 0.748 |
PAK3 |
0.781 | -0.088 | -2 | 0.747 |
RIPK1 |
0.781 | -0.200 | 1 | 0.750 |
SIK |
0.780 | -0.057 | -3 | 0.634 |
MEK1 |
0.780 | -0.113 | 2 | 0.658 |
CLK4 |
0.780 | -0.015 | -3 | 0.643 |
PRKD3 |
0.780 | -0.066 | -3 | 0.627 |
PASK |
0.779 | 0.098 | -3 | 0.706 |
YSK4 |
0.779 | -0.122 | 1 | 0.719 |
JNK2 |
0.779 | -0.005 | 1 | 0.501 |
PAK6 |
0.779 | -0.020 | -2 | 0.681 |
IRE2 |
0.779 | -0.144 | 2 | 0.566 |
PKCB |
0.779 | -0.079 | 2 | 0.560 |
JNK3 |
0.779 | -0.014 | 1 | 0.532 |
MLK4 |
0.778 | -0.102 | 2 | 0.563 |
SMG1 |
0.778 | -0.062 | 1 | 0.672 |
PIM2 |
0.778 | 0.004 | -3 | 0.623 |
PKG2 |
0.778 | -0.012 | -2 | 0.671 |
NEK2 |
0.778 | -0.150 | 2 | 0.606 |
GSK3B |
0.778 | 0.126 | 4 | 0.608 |
MNK1 |
0.777 | -0.044 | -2 | 0.783 |
QIK |
0.777 | -0.128 | -3 | 0.708 |
CLK1 |
0.776 | -0.033 | -3 | 0.633 |
PAK2 |
0.776 | -0.078 | -2 | 0.733 |
GRK3 |
0.776 | 0.082 | -2 | 0.631 |
IRE1 |
0.775 | -0.202 | 1 | 0.708 |
CAMK1D |
0.775 | 0.012 | -3 | 0.568 |
DYRK2 |
0.775 | -0.059 | 1 | 0.570 |
PKCA |
0.775 | -0.099 | 2 | 0.554 |
PKCG |
0.775 | -0.101 | 2 | 0.547 |
DCAMKL1 |
0.775 | -0.040 | -3 | 0.662 |
PERK |
0.774 | -0.141 | -2 | 0.817 |
SSTK |
0.774 | -0.016 | 4 | 0.797 |
VRK2 |
0.774 | -0.295 | 1 | 0.769 |
CDK19 |
0.774 | -0.084 | 1 | 0.493 |
CDK7 |
0.774 | -0.093 | 1 | 0.549 |
PKCH |
0.774 | -0.109 | 2 | 0.538 |
SRPK3 |
0.773 | -0.066 | -3 | 0.590 |
PKACA |
0.773 | 0.016 | -2 | 0.624 |
SGK3 |
0.773 | -0.040 | -3 | 0.620 |
CDK1 |
0.772 | -0.051 | 1 | 0.526 |
CAMK1G |
0.772 | -0.066 | -3 | 0.640 |
PLK4 |
0.772 | -0.127 | 2 | 0.460 |
MAPKAPK5 |
0.772 | -0.102 | -3 | 0.583 |
P38B |
0.771 | -0.035 | 1 | 0.523 |
AKT2 |
0.771 | -0.039 | -3 | 0.562 |
PHKG1 |
0.770 | -0.161 | -3 | 0.694 |
P38A |
0.770 | -0.065 | 1 | 0.590 |
CDK5 |
0.770 | -0.076 | 1 | 0.571 |
TLK1 |
0.770 | -0.080 | -2 | 0.811 |
P70S6K |
0.769 | -0.052 | -3 | 0.579 |
PKCZ |
0.768 | -0.147 | 2 | 0.581 |
DCAMKL2 |
0.768 | -0.067 | -3 | 0.701 |
HRI |
0.768 | -0.212 | -2 | 0.827 |
CHAK1 |
0.767 | -0.236 | 2 | 0.553 |
CDK2 |
0.767 | -0.086 | 1 | 0.614 |
PRP4 |
0.767 | -0.018 | -3 | 0.732 |
SNRK |
0.767 | -0.218 | 2 | 0.499 |
CDK13 |
0.766 | -0.100 | 1 | 0.522 |
ERK2 |
0.766 | -0.090 | 1 | 0.551 |
P38G |
0.764 | -0.052 | 1 | 0.434 |
MEKK3 |
0.764 | -0.168 | 1 | 0.751 |
ERK1 |
0.764 | -0.080 | 1 | 0.509 |
GAK |
0.764 | 0.009 | 1 | 0.772 |
SMMLCK |
0.764 | -0.062 | -3 | 0.697 |
NEK5 |
0.764 | -0.201 | 1 | 0.754 |
DAPK3 |
0.764 | 0.010 | -3 | 0.669 |
CDK18 |
0.764 | -0.079 | 1 | 0.481 |
MEKK1 |
0.763 | -0.237 | 1 | 0.724 |
ZAK |
0.763 | -0.198 | 1 | 0.719 |
WNK4 |
0.763 | -0.189 | -2 | 0.820 |
DYRK4 |
0.763 | -0.036 | 1 | 0.499 |
TTBK1 |
0.763 | -0.145 | 2 | 0.443 |
CDK9 |
0.762 | -0.108 | 1 | 0.531 |
CAMKK1 |
0.762 | -0.113 | -2 | 0.735 |
CDK3 |
0.762 | -0.045 | 1 | 0.457 |
HIPK2 |
0.762 | -0.063 | 1 | 0.480 |
LKB1 |
0.761 | -0.092 | -3 | 0.744 |
MEKK2 |
0.761 | -0.199 | 2 | 0.618 |
P38D |
0.761 | -0.037 | 1 | 0.428 |
HIPK1 |
0.761 | -0.079 | 1 | 0.581 |
CAMKK2 |
0.761 | -0.088 | -2 | 0.726 |
TAO3 |
0.761 | -0.119 | 1 | 0.730 |
MEK5 |
0.760 | -0.309 | 2 | 0.634 |
DYRK1A |
0.760 | -0.091 | 1 | 0.606 |
DAPK1 |
0.760 | 0.024 | -3 | 0.643 |
CDK17 |
0.760 | -0.084 | 1 | 0.438 |
AKT1 |
0.760 | -0.054 | -3 | 0.572 |
IRAK4 |
0.759 | -0.215 | 1 | 0.717 |
PKCT |
0.759 | -0.133 | 2 | 0.553 |
DYRK1B |
0.759 | -0.057 | 1 | 0.532 |
JNK1 |
0.758 | -0.023 | 1 | 0.494 |
MST3 |
0.758 | -0.130 | 2 | 0.622 |
PHKG2 |
0.758 | -0.136 | -3 | 0.685 |
CDK12 |
0.758 | -0.104 | 1 | 0.496 |
ERK7 |
0.758 | -0.064 | 2 | 0.400 |
EEF2K |
0.757 | -0.080 | 3 | 0.683 |
PAK5 |
0.757 | -0.067 | -2 | 0.606 |
PINK1 |
0.757 | -0.226 | 1 | 0.691 |
CDK16 |
0.756 | -0.052 | 1 | 0.450 |
MST2 |
0.756 | -0.093 | 1 | 0.758 |
CK1E |
0.756 | -0.092 | -3 | 0.378 |
MRCKA |
0.756 | 0.006 | -3 | 0.628 |
PAK4 |
0.755 | -0.058 | -2 | 0.616 |
NEK8 |
0.755 | -0.214 | 2 | 0.611 |
MPSK1 |
0.755 | -0.119 | 1 | 0.674 |
SGK1 |
0.754 | -0.010 | -3 | 0.473 |
TAO2 |
0.754 | -0.164 | 2 | 0.662 |
IRAK1 |
0.754 | -0.235 | -1 | 0.728 |
CAMK1A |
0.753 | -0.050 | -3 | 0.535 |
PKCI |
0.753 | -0.129 | 2 | 0.551 |
GCK |
0.753 | -0.093 | 1 | 0.760 |
CK1G1 |
0.751 | -0.119 | -3 | 0.398 |
DYRK3 |
0.751 | -0.079 | 1 | 0.580 |
HIPK3 |
0.751 | -0.134 | 1 | 0.584 |
AKT3 |
0.751 | -0.040 | -3 | 0.491 |
SBK |
0.750 | -0.020 | -3 | 0.458 |
TAK1 |
0.750 | -0.136 | 1 | 0.769 |
CDK14 |
0.749 | -0.103 | 1 | 0.524 |
PDK1 |
0.748 | -0.170 | 1 | 0.734 |
PKCE |
0.748 | -0.092 | 2 | 0.532 |
CDK10 |
0.748 | -0.078 | 1 | 0.511 |
NEK4 |
0.748 | -0.234 | 1 | 0.713 |
ROCK2 |
0.748 | -0.020 | -3 | 0.650 |
MRCKB |
0.748 | -0.036 | -3 | 0.610 |
NEK1 |
0.748 | -0.196 | 1 | 0.732 |
CK1D |
0.747 | -0.086 | -3 | 0.325 |
MST1 |
0.747 | -0.124 | 1 | 0.731 |
NEK11 |
0.747 | -0.276 | 1 | 0.737 |
MINK |
0.747 | -0.159 | 1 | 0.728 |
TNIK |
0.747 | -0.136 | 3 | 0.677 |
HGK |
0.747 | -0.169 | 3 | 0.665 |
PDHK3_TYR |
0.746 | 0.268 | 4 | 0.892 |
VRK1 |
0.746 | -0.216 | 2 | 0.630 |
PKN1 |
0.744 | -0.123 | -3 | 0.599 |
LOK |
0.743 | -0.160 | -2 | 0.732 |
CHK2 |
0.743 | -0.099 | -3 | 0.514 |
DMPK1 |
0.742 | 0.003 | -3 | 0.636 |
MEK2 |
0.742 | -0.236 | 2 | 0.627 |
CK1A2 |
0.742 | -0.100 | -3 | 0.319 |
BUB1 |
0.742 | -0.071 | -5 | 0.722 |
HPK1 |
0.742 | -0.129 | 1 | 0.739 |
LRRK2 |
0.742 | -0.249 | 2 | 0.640 |
MEKK6 |
0.742 | -0.268 | 1 | 0.734 |
ALPHAK3 |
0.741 | 0.071 | -1 | 0.745 |
MAP3K15 |
0.741 | -0.255 | 1 | 0.701 |
MAK |
0.740 | -0.048 | -2 | 0.705 |
SLK |
0.740 | -0.131 | -2 | 0.672 |
PBK |
0.740 | -0.082 | 1 | 0.694 |
KHS1 |
0.740 | -0.131 | 1 | 0.711 |
KHS2 |
0.739 | -0.096 | 1 | 0.728 |
TTK |
0.739 | -0.078 | -2 | 0.817 |
STK33 |
0.738 | -0.184 | 2 | 0.436 |
CRIK |
0.738 | -0.029 | -3 | 0.572 |
CDK6 |
0.737 | -0.113 | 1 | 0.499 |
CDK4 |
0.737 | -0.106 | 1 | 0.477 |
RIPK2 |
0.737 | -0.270 | 1 | 0.677 |
PKG1 |
0.737 | -0.075 | -2 | 0.592 |
MOK |
0.737 | -0.075 | 1 | 0.608 |
PDHK4_TYR |
0.737 | 0.147 | 2 | 0.707 |
YSK1 |
0.736 | -0.202 | 2 | 0.614 |
BIKE |
0.734 | -0.024 | 1 | 0.646 |
MAP2K6_TYR |
0.733 | 0.109 | -1 | 0.836 |
TESK1_TYR |
0.732 | -0.038 | 3 | 0.739 |
ROCK1 |
0.732 | -0.054 | -3 | 0.622 |
PDHK1_TYR |
0.730 | 0.064 | -1 | 0.850 |
EPHA6 |
0.730 | 0.060 | -1 | 0.818 |
NEK3 |
0.730 | -0.254 | 1 | 0.677 |
BMPR2_TYR |
0.730 | 0.079 | -1 | 0.806 |
MAP2K4_TYR |
0.729 | -0.027 | -1 | 0.835 |
OSR1 |
0.729 | -0.153 | 2 | 0.608 |
MAP2K7_TYR |
0.728 | -0.101 | 2 | 0.682 |
EPHA4 |
0.725 | 0.081 | 2 | 0.632 |
ASK1 |
0.724 | -0.207 | 1 | 0.686 |
EPHB4 |
0.724 | 0.008 | -1 | 0.811 |
SRMS |
0.723 | 0.090 | 1 | 0.859 |
TXK |
0.723 | 0.099 | 1 | 0.863 |
YANK3 |
0.723 | -0.103 | 2 | 0.288 |
PKMYT1_TYR |
0.722 | -0.185 | 3 | 0.699 |
PINK1_TYR |
0.721 | -0.183 | 1 | 0.768 |
DDR1 |
0.721 | -0.063 | 4 | 0.822 |
FER |
0.721 | -0.009 | 1 | 0.853 |
INSRR |
0.721 | 0.019 | 3 | 0.599 |
LIMK2_TYR |
0.719 | -0.135 | -3 | 0.796 |
YES1 |
0.719 | -0.003 | -1 | 0.812 |
RET |
0.719 | -0.139 | 1 | 0.725 |
TAO1 |
0.719 | -0.199 | 1 | 0.652 |
EPHB1 |
0.719 | 0.016 | 1 | 0.845 |
EPHB2 |
0.718 | 0.051 | -1 | 0.795 |
MYO3B |
0.718 | -0.212 | 2 | 0.626 |
TYRO3 |
0.718 | -0.146 | 3 | 0.622 |
CK1A |
0.717 | -0.078 | -3 | 0.241 |
AAK1 |
0.717 | -0.008 | 1 | 0.545 |
EPHB3 |
0.716 | -0.010 | -1 | 0.798 |
HASPIN |
0.715 | -0.141 | -1 | 0.628 |
MYO3A |
0.715 | -0.224 | 1 | 0.698 |
FGR |
0.715 | -0.079 | 1 | 0.816 |
STLK3 |
0.714 | -0.201 | 1 | 0.681 |
TYK2 |
0.714 | -0.252 | 1 | 0.724 |
ROS1 |
0.714 | -0.200 | 3 | 0.593 |
MERTK |
0.713 | -0.030 | 3 | 0.617 |
LIMK1_TYR |
0.712 | -0.253 | 2 | 0.673 |
ITK |
0.712 | -0.043 | -1 | 0.770 |
ABL2 |
0.712 | -0.088 | -1 | 0.778 |
HCK |
0.712 | -0.076 | -1 | 0.792 |
FGFR2 |
0.712 | -0.075 | 3 | 0.651 |
EPHA7 |
0.711 | 0.011 | 2 | 0.623 |
MST1R |
0.711 | -0.235 | 3 | 0.631 |
EPHA5 |
0.710 | 0.067 | 2 | 0.633 |
TEC |
0.710 | -0.034 | -1 | 0.716 |
CSF1R |
0.710 | -0.171 | 3 | 0.603 |
JAK2 |
0.710 | -0.248 | 1 | 0.718 |
FYN |
0.709 | 0.038 | -1 | 0.754 |
BLK |
0.709 | -0.019 | -1 | 0.792 |
AXL |
0.709 | -0.106 | 3 | 0.614 |
LCK |
0.709 | -0.057 | -1 | 0.790 |
JAK3 |
0.708 | -0.148 | 1 | 0.721 |
PDGFRB |
0.708 | -0.179 | 3 | 0.620 |
TNK2 |
0.707 | -0.136 | 3 | 0.578 |
EPHA3 |
0.707 | -0.040 | 2 | 0.605 |
ABL1 |
0.707 | -0.120 | -1 | 0.773 |
FGFR1 |
0.706 | -0.136 | 3 | 0.616 |
LTK |
0.706 | -0.097 | 3 | 0.579 |
BMX |
0.706 | -0.034 | -1 | 0.678 |
PTK2B |
0.705 | 0.010 | -1 | 0.750 |
DDR2 |
0.704 | -0.017 | 3 | 0.583 |
NTRK1 |
0.704 | -0.099 | -1 | 0.784 |
NEK10_TYR |
0.704 | -0.148 | 1 | 0.606 |
TEK |
0.704 | -0.155 | 3 | 0.575 |
ALK |
0.703 | -0.135 | 3 | 0.555 |
PTK6 |
0.703 | -0.151 | -1 | 0.713 |
FLT3 |
0.702 | -0.192 | 3 | 0.604 |
KIT |
0.702 | -0.159 | 3 | 0.613 |
INSR |
0.701 | -0.093 | 3 | 0.573 |
EGFR |
0.701 | -0.000 | 1 | 0.645 |
BTK |
0.701 | -0.149 | -1 | 0.746 |
TNNI3K_TYR |
0.700 | -0.168 | 1 | 0.705 |
FGFR3 |
0.700 | -0.095 | 3 | 0.627 |
PTK2 |
0.700 | 0.060 | -1 | 0.736 |
TNK1 |
0.699 | -0.210 | 3 | 0.607 |
EPHA1 |
0.699 | -0.117 | 3 | 0.574 |
LYN |
0.699 | -0.065 | 3 | 0.559 |
EPHA8 |
0.699 | -0.025 | -1 | 0.757 |
ERBB2 |
0.698 | -0.129 | 1 | 0.721 |
CK1G3 |
0.698 | -0.098 | -3 | 0.195 |
NTRK2 |
0.698 | -0.168 | 3 | 0.597 |
FRK |
0.697 | -0.113 | -1 | 0.810 |
JAK1 |
0.697 | -0.213 | 1 | 0.676 |
PDGFRA |
0.697 | -0.275 | 3 | 0.618 |
KDR |
0.696 | -0.201 | 3 | 0.579 |
SYK |
0.696 | 0.059 | -1 | 0.731 |
FLT1 |
0.695 | -0.117 | -1 | 0.805 |
MET |
0.695 | -0.162 | 3 | 0.603 |
SRC |
0.694 | -0.055 | -1 | 0.756 |
NTRK3 |
0.694 | -0.117 | -1 | 0.736 |
EPHA2 |
0.694 | -0.003 | -1 | 0.733 |
FLT4 |
0.693 | -0.179 | 3 | 0.598 |
FGFR4 |
0.692 | -0.060 | -1 | 0.749 |
CSK |
0.691 | -0.111 | 2 | 0.618 |
IGF1R |
0.690 | -0.069 | 3 | 0.538 |
YANK2 |
0.690 | -0.121 | 2 | 0.314 |
WEE1_TYR |
0.689 | -0.191 | -1 | 0.715 |
ERBB4 |
0.684 | -0.030 | 1 | 0.684 |
MATK |
0.684 | -0.149 | -1 | 0.704 |
MUSK |
0.676 | -0.187 | 1 | 0.637 |
FES |
0.675 | -0.084 | -1 | 0.660 |
CK1G2 |
0.674 | -0.100 | -3 | 0.299 |
ZAP70 |
0.651 | -0.115 | -1 | 0.630 |