Motif 671 (n=137)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NDB9 | PALM3 | S544 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
E9PCH4 | None | S690 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
O15061 | SYNM | S1432 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15063 | GARRE1 | S665 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
O43491 | EPB41L2 | S87 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O60271 | SPAG9 | S314 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
O75334 | PPFIA2 | S260 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
O95613 | PCNT | S2479 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
P02545 | LMNA | S571 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P02686 | MBP | S112 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
P06213 | INSR | S1333 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
P08238 | HSP90AB1 | S460 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
P0DP23 | CALM1 | Y100 | ochoa|psp | Calmodulin-1 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:23893133, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. {ECO:0000269|PubMed:31330532}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
P0DP24 | CALM2 | Y100 | ochoa | Calmodulin-2 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
P0DP25 | CALM3 | Y100 | ochoa | Calmodulin-3 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
P10451 | SPP1 | S81 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
P13861 | PRKAR2A | S99 | ochoa|psp | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
P17948 | FLT1 | S1001 | ochoa | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
P30566 | ADSL | S434 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
P31321 | PRKAR1B | S75 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
P31751 | AKT2 | S34 | ochoa | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) | Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (PubMed:31204173). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (PubMed:23444369). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:31204173, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.; FUNCTION: Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes CCND1 cyclin mRNA, ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity). {ECO:0000250|UniProtKB:Q60823}. |
P33981 | TTK | S393 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
P34910 | EVI2B | S278 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
P35226 | BMI1 | S110 | psp | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332). {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:27827373}. |
P41236 | PPP1R2 | S87 | ochoa|psp | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
P41250 | GARS1 | S653 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
P43243 | MATR3 | S766 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
P46100 | ATRX | S1153 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P48634 | PRRC2A | S1110 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
P48681 | NES | S743 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
P52565 | ARHGDIA | S174 | psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
P53004 | BLVRA | S21 | psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
P54296 | MYOM2 | S1042 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P56182 | RRP1 | S272 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
P78332 | RBM6 | S370 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
P78527 | PRKDC | S3215 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
P98088 | MUC5AC | S5628 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
Q01664 | TFAP4 | S139 | ochoa|psp | Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) | Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. |
Q01970 | PLCB3 | S1105 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
Q02410 | APBA1 | S285 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
Q02818 | NUCB1 | S224 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
Q03188 | CENPC | S290 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
Q04206 | RELA | S42 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
Q04726 | TLE3 | S245 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
Q12888 | TP53BP1 | S103 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12888 | TP53BP1 | S566 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q13127 | REST | S1024 | psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
Q13501 | SQSTM1 | S318 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
Q13554 | CAMK2B | S395 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
Q13573 | SNW1 | S446 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
Q14126 | DSG2 | S999 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
Q14134 | TRIM29 | S164 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
Q14432 | PDE3A | S657 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
Q14562 | DHX8 | S377 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
Q14692 | BMS1 | S625 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
Q147X3 | NAA30 | S199 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
Q14D04 | VEPH1 | S420 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
Q15047 | SETDB1 | S917 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
Q15058 | KIF14 | S607 | psp | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
Q15652 | JMJD1C | S376 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
Q16630 | CPSF6 | S38 | ochoa | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}. |
Q16658 | FSCN1 | S274 | psp | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
Q63HQ0 | AP1AR | S226 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
Q68DQ2 | CRYBG3 | S445 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
Q69YH5 | CDCA2 | S666 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
Q6UXG2 | ELAPOR1 | S987 | ochoa | Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) | May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}. |
Q6WKZ4 | RAB11FIP1 | S496 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q6ZVF9 | GPRIN3 | S517 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7KZI7 | MARK2 | S675 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q7Z2Y5 | NRK | S1031 | ochoa | Nik-related protein kinase (EC 2.7.11.1) | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}. |
Q7Z4V5 | HDGFL2 | S366 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
Q7Z4V5 | HDGFL2 | S652 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
Q7Z569 | BRAP | S286 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
Q7Z5K2 | WAPL | Y452 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
Q7Z6Z7 | HUWE1 | S2339 | psp | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
Q86W50 | METTL16 | S484 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
Q8IU57 | IFNLR1 | S498 | ochoa | Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2) | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}. |
Q8IZE3 | SCYL3 | S568 | ochoa | Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) | May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}. |
Q8N392 | ARHGAP18 | S66 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
Q8N554 | ZNF276 | S357 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
Q8N7H5 | PAF1 | S456 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
Q8N8R7 | ARL14EP | S183 | ochoa | ARL14 effector protein (ARF7 effector protein) | Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}. |
Q8NI08 | NCOA7 | S505 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
Q8TD26 | CHD6 | S1673 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
Q8TDJ6 | DMXL2 | S451 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
Q8TEU7 | RAPGEF6 | S640 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
Q8WYP5 | AHCTF1 | S1371 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
Q92769 | HDAC2 | S407 | ochoa | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
Q96DT7 | ZBTB10 | S565 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
Q96DX4 | RSPRY1 | S521 | ochoa | RING finger and SPRY domain-containing protein 1 | None |
Q96HU1 | SGSM3 | S59 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
Q96LB3 | IFT74 | S300 | ochoa | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) | Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}. |
Q96Q15 | SMG1 | S1917 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
Q96RL1 | UIMC1 | S27 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
Q99590 | SCAF11 | S530 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
Q9BTC0 | DIDO1 | S352 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BUR4 | WRAP53 | S112 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
Q9BV36 | MLPH | S481 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BX63 | BRIP1 | S1162 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
Q9BXL5 | HEMGN | S188 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
Q9BYB0 | SHANK3 | S558 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9C0C2 | TNKS1BP1 | S966 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H0G5 | NSRP1 | S446 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
Q9H0H5 | RACGAP1 | S114 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
Q9H0X9 | OSBPL5 | S327 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
Q9H2G2 | SLK | S667 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
Q9H334 | FOXP1 | S658 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
Q9H4A3 | WNK1 | S2002 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Q9H5J8 | TAF1D | S204 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
Q9H5J8 | TAF1D | S206 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
Q9H9A7 | RMI1 | S400 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
Q9NV56 | MRGBP | S149 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
Q9NYM9 | BET1L | S37 | ochoa | BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) | Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}. |
Q9NZL9 | MAT2B | S210 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
Q9P0L2 | MARK1 | S468 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Q9P2G1 | ANKIB1 | S782 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9P2R7 | SUCLA2 | S279 | ochoa | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) | ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282, PubMed:34492704). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282, ECO:0000269|PubMed:34492704}. |
Q9UBL3 | ASH2L | S92 | ochoa | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
Q9UDY2 | TJP2 | S913 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
Q9UGP8 | SEC63 | S597 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
Q9UHI6 | DDX20 | S703 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
Q9UIS9 | MBD1 | S557 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
Q9UNE7 | STUB1 | S191 | ochoa | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
Q9UPN4 | CEP131 | S534 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
Q9UPQ0 | LIMCH1 | S325 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9Y243 | AKT3 | S34 | ochoa | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}. |
Q9Y266 | NUDC | S100 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
Q9Y2W1 | THRAP3 | S508 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
Q9Y4F1 | FARP1 | S833 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
P07900 | HSP90AA1 | S468 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
Q7Z4H3 | HDDC2 | S170 | Sugiyama | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}. |
Q8IZ69 | TRMT2A | S480 | Sugiyama | tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}. |
Q9UBR2 | CTSZ | S195 | Sugiyama | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}. |
Q92769 | HDAC2 | S89 | Sugiyama | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
P32969 | RPL9 | S137 | Sugiyama | Large ribosomal subunit protein uL6 (60S ribosomal protein L9) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
Q96KB5 | PBK | S110 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
Q9NP61 | ARFGAP3 | S429 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 0.000589 | 3.230 |
R-HSA-111997 | CaM pathway | 0.000774 | 3.111 |
R-HSA-111933 | Calmodulin induced events | 0.000774 | 3.111 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.000589 | 3.230 |
R-HSA-112043 | PLC beta mediated events | 0.000526 | 3.279 |
R-HSA-112040 | G-protein mediated events | 0.000764 | 3.117 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.000667 | 3.176 |
R-HSA-9948001 | CASP4 inflammasome assembly | 0.000271 | 3.568 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.000400 | 3.398 |
R-HSA-1640170 | Cell Cycle | 0.000058 | 4.234 |
R-HSA-9686114 | Non-canonical inflammasome activation | 0.000694 | 3.158 |
R-HSA-163615 | PKA activation | 0.001400 | 2.854 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.001400 | 2.854 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.001160 | 2.936 |
R-HSA-111996 | Ca-dependent events | 0.001346 | 2.871 |
R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.001515 | 2.820 |
R-HSA-1489509 | DAG and IP3 signaling | 0.001663 | 2.779 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.001981 | 2.703 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.002961 | 2.528 |
R-HSA-68877 | Mitotic Prometaphase | 0.004085 | 2.389 |
R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.004107 | 2.386 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.004107 | 2.386 |
R-HSA-1227986 | Signaling by ERBB2 | 0.004046 | 2.393 |
R-HSA-6807070 | PTEN Regulation | 0.003734 | 2.428 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.005842 | 2.233 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.004939 | 2.306 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.006815 | 2.167 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.004471 | 2.350 |
R-HSA-111885 | Opioid Signalling | 0.004810 | 2.318 |
R-HSA-180024 | DARPP-32 events | 0.004545 | 2.342 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.006120 | 2.213 |
R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.006815 | 2.167 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.006120 | 2.213 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.004939 | 2.306 |
R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.005842 | 2.233 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.006120 | 2.213 |
R-HSA-5673000 | RAF activation | 0.007015 | 2.154 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.005472 | 2.262 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.007002 | 2.155 |
R-HSA-8953897 | Cellular responses to stimuli | 0.006527 | 2.185 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005700 | 2.244 |
R-HSA-5357801 | Programmed Cell Death | 0.005608 | 2.251 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.007740 | 2.111 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.007855 | 2.105 |
R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.007855 | 2.105 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.008497 | 2.071 |
R-HSA-209560 | NF-kB is activated and signals survival | 0.008963 | 2.048 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.010136 | 1.994 |
R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.010136 | 1.994 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.009642 | 2.016 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.010217 | 1.991 |
R-HSA-194138 | Signaling by VEGF | 0.010696 | 1.971 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.010737 | 1.969 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.011373 | 1.944 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.011840 | 1.927 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.011840 | 1.927 |
R-HSA-438064 | Post NMDA receptor activation events | 0.013160 | 1.881 |
R-HSA-193639 | p75NTR signals via NF-kB | 0.014034 | 1.853 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.014034 | 1.853 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.014681 | 1.833 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.014681 | 1.833 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.014681 | 1.833 |
R-HSA-68886 | M Phase | 0.014247 | 1.846 |
R-HSA-6802949 | Signaling by RAS mutants | 0.014681 | 1.833 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.014034 | 1.853 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.014034 | 1.853 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.012653 | 1.898 |
R-HSA-75153 | Apoptotic execution phase | 0.014681 | 1.833 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.018581 | 1.731 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.018581 | 1.731 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.018581 | 1.731 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.018581 | 1.731 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.018581 | 1.731 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.016155 | 1.792 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.016921 | 1.772 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.016937 | 1.771 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.020072 | 1.697 |
R-HSA-6794361 | Neurexins and neuroligins | 0.019343 | 1.713 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.018515 | 1.732 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.019343 | 1.713 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.016937 | 1.771 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.020072 | 1.697 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.020190 | 1.695 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.016450 | 1.784 |
R-HSA-9711123 | Cellular response to chemical stress | 0.019525 | 1.709 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.019343 | 1.713 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.021723 | 1.663 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.023428 | 1.630 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.023428 | 1.630 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.023428 | 1.630 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.023428 | 1.630 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.023169 | 1.635 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.022823 | 1.642 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.020541 | 1.687 |
R-HSA-844456 | The NLRP3 inflammasome | 0.021723 | 1.663 |
R-HSA-389513 | Co-inhibition by CTLA4 | 0.023428 | 1.630 |
R-HSA-73887 | Death Receptor Signaling | 0.023681 | 1.626 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.023686 | 1.626 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.021766 | 1.662 |
R-HSA-68882 | Mitotic Anaphase | 0.024544 | 1.610 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.036818 | 1.434 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.036818 | 1.434 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.036818 | 1.434 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.036818 | 1.434 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.036818 | 1.434 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.036818 | 1.434 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.036818 | 1.434 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.036818 | 1.434 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.036818 | 1.434 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.036818 | 1.434 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.036818 | 1.434 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.026998 | 1.569 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.026998 | 1.569 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.026998 | 1.569 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.028860 | 1.540 |
R-HSA-9620244 | Long-term potentiation | 0.034741 | 1.459 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.034741 | 1.459 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.027696 | 1.558 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.029775 | 1.526 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.029775 | 1.526 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.031933 | 1.496 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.033043 | 1.481 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.028860 | 1.540 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.031586 | 1.501 |
R-HSA-5693538 | Homology Directed Repair | 0.036475 | 1.438 |
R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.036818 | 1.434 |
R-HSA-1482801 | Acyl chain remodelling of PS | 0.034741 | 1.459 |
R-HSA-352238 | Breakdown of the nuclear lamina | 0.027742 | 1.557 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.029796 | 1.526 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.033979 | 1.469 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.026687 | 1.574 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.030772 | 1.512 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.024988 | 1.602 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.030772 | 1.512 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.026998 | 1.569 |
R-HSA-2262752 | Cellular responses to stress | 0.035186 | 1.454 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.033364 | 1.477 |
R-HSA-8939211 | ESR-mediated signaling | 0.035010 | 1.456 |
R-HSA-186712 | Regulation of beta-cell development | 0.025699 | 1.590 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.026906 | 1.570 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.030772 | 1.512 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.030225 | 1.520 |
R-HSA-109581 | Apoptosis | 0.028041 | 1.552 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.036832 | 1.434 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.038897 | 1.410 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.039074 | 1.408 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.039074 | 1.408 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.041043 | 1.387 |
R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.041043 | 1.387 |
R-HSA-622312 | Inflammasomes | 0.041043 | 1.387 |
R-HSA-209563 | Axonal growth stimulation | 0.045810 | 1.339 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.045810 | 1.339 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.045810 | 1.339 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.054719 | 1.262 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.043232 | 1.364 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.041361 | 1.383 |
R-HSA-380287 | Centrosome maturation | 0.043914 | 1.357 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.054799 | 1.261 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.052406 | 1.281 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.052406 | 1.281 |
R-HSA-5617833 | Cilium Assembly | 0.047947 | 1.319 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.054719 | 1.262 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.045219 | 1.345 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.043780 | 1.359 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.052406 | 1.281 |
R-HSA-112316 | Neuronal System | 0.041764 | 1.379 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.050631 | 1.296 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.052406 | 1.281 |
R-HSA-8852135 | Protein ubiquitination | 0.043914 | 1.357 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.052406 | 1.281 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.054799 | 1.261 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.050631 | 1.296 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.045464 | 1.342 |
R-HSA-69481 | G2/M Checkpoints | 0.045541 | 1.342 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.054799 | 1.261 |
R-HSA-162582 | Signal Transduction | 0.053540 | 1.271 |
R-HSA-4839726 | Chromatin organization | 0.042116 | 1.376 |
R-HSA-210745 | Regulation of gene expression in beta cells | 0.043232 | 1.364 |
R-HSA-114452 | Activation of BH3-only proteins | 0.045464 | 1.342 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.056343 | 1.249 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.057229 | 1.242 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.057229 | 1.242 |
R-HSA-203615 | eNOS activation | 0.057229 | 1.242 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.059310 | 1.227 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.059310 | 1.227 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.059697 | 1.224 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.059697 | 1.224 |
R-HSA-8953854 | Metabolism of RNA | 0.059847 | 1.223 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.060820 | 1.216 |
R-HSA-74713 | IRS activation | 0.063545 | 1.197 |
R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.063545 | 1.197 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.072290 | 1.141 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.089536 | 1.048 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.089536 | 1.048 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.063894 | 1.195 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.067039 | 1.174 |
R-HSA-9646399 | Aggrephagy | 0.072561 | 1.139 |
R-HSA-165158 | Activation of AKT2 | 0.063545 | 1.197 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.080668 | 1.093 |
R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.072290 | 1.141 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.087332 | 1.059 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.063638 | 1.196 |
R-HSA-111957 | Cam-PDE 1 activation | 0.072290 | 1.141 |
R-HSA-109703 | PKB-mediated events | 0.072290 | 1.141 |
R-HSA-165160 | PDE3B signalling | 0.072290 | 1.141 |
R-HSA-3371511 | HSF1 activation | 0.062201 | 1.206 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.067314 | 1.172 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.067314 | 1.172 |
R-HSA-9663891 | Selective autophagy | 0.063894 | 1.195 |
R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.072290 | 1.141 |
R-HSA-9612973 | Autophagy | 0.082176 | 1.085 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.080953 | 1.092 |
R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.072290 | 1.141 |
R-HSA-194313 | VEGF ligand-receptor interactions | 0.072290 | 1.141 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.091887 | 1.037 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.091887 | 1.037 |
R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.063545 | 1.197 |
R-HSA-3371568 | Attenuation phase | 0.072561 | 1.139 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.067314 | 1.172 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.089041 | 1.050 |
R-HSA-9675135 | Diseases of DNA repair | 0.091887 | 1.037 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.077935 | 1.108 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.089041 | 1.050 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.077935 | 1.108 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.082037 | 1.086 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.068638 | 1.163 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.089041 | 1.050 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.080668 | 1.093 |
R-HSA-422356 | Regulation of insulin secretion | 0.083786 | 1.077 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.076887 | 1.114 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.076093 | 1.119 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.074444 | 1.128 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.070254 | 1.153 |
R-HSA-9614085 | FOXO-mediated transcription | 0.085552 | 1.068 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.062201 | 1.206 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.069921 | 1.155 |
R-HSA-9607240 | FLT3 Signaling | 0.075232 | 1.124 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.069921 | 1.155 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.093076 | 1.031 |
R-HSA-9679506 | SARS-CoV Infections | 0.093604 | 1.029 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.114809 | 0.940 |
R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.114809 | 0.940 |
R-HSA-3000484 | Scavenging by Class F Receptors | 0.139386 | 0.856 |
R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.171103 | 0.767 |
R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.171103 | 0.767 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.186523 | 0.729 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.186523 | 0.729 |
R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.186523 | 0.729 |
R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.194126 | 0.712 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.141185 | 0.850 |
R-HSA-72172 | mRNA Splicing | 0.160249 | 0.795 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.159980 | 0.796 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.106463 | 0.973 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.131034 | 0.883 |
R-HSA-191859 | snRNP Assembly | 0.131034 | 0.883 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.111854 | 0.951 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.111854 | 0.951 |
R-HSA-4641265 | Repression of WNT target genes | 0.139386 | 0.856 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.139386 | 0.856 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.169876 | 0.770 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.103149 | 0.987 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.098039 | 1.009 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.106463 | 0.973 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.155392 | 0.809 |
R-HSA-72187 | mRNA 3'-end processing | 0.109493 | 0.961 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.193334 | 0.714 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.186586 | 0.729 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.156705 | 0.805 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.134187 | 0.872 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.134187 | 0.872 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.134187 | 0.872 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.134187 | 0.872 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.169876 | 0.770 |
R-HSA-193697 | p75NTR regulates axonogenesis | 0.106463 | 0.973 |
R-HSA-451306 | Ionotropic activity of kainate receptors | 0.123078 | 0.910 |
R-HSA-192905 | vRNP Assembly | 0.123078 | 0.910 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.131270 | 0.882 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.139386 | 0.856 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.163284 | 0.787 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.171103 | 0.767 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.194126 | 0.712 |
R-HSA-500657 | Presynaptic function of Kainate receptors | 0.194126 | 0.712 |
R-HSA-9843745 | Adipogenesis | 0.160630 | 0.794 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.166565 | 0.778 |
R-HSA-209543 | p75NTR recruits signalling complexes | 0.139386 | 0.856 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.194126 | 0.712 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.166565 | 0.778 |
R-HSA-3214815 | HDACs deacetylate histones | 0.118605 | 0.926 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.146965 | 0.833 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.105978 | 0.975 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.176530 | 0.753 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.131197 | 0.882 |
R-HSA-73886 | Chromosome Maintenance | 0.134410 | 0.872 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.098039 | 1.009 |
R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.131270 | 0.882 |
R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.171103 | 0.767 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.194126 | 0.712 |
R-HSA-1221632 | Meiotic synapsis | 0.112509 | 0.949 |
R-HSA-9664873 | Pexophagy | 0.114809 | 0.940 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.134187 | 0.872 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.156155 | 0.806 |
R-HSA-4086398 | Ca2+ pathway | 0.176530 | 0.753 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 0.155392 | 0.809 |
R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.178849 | 0.748 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.194126 | 0.712 |
R-HSA-389356 | Co-stimulation by CD28 | 0.097657 | 1.010 |
R-HSA-425561 | Sodium/Calcium exchangers | 0.131270 | 0.882 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.171103 | 0.767 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.124781 | 0.904 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.127898 | 0.893 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.131034 | 0.883 |
R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.106463 | 0.973 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.153445 | 0.814 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.101873 | 0.992 |
R-HSA-1632852 | Macroautophagy | 0.185904 | 0.731 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.151467 | 0.820 |
R-HSA-3371556 | Cellular response to heat stress | 0.134410 | 0.872 |
R-HSA-448706 | Interleukin-1 processing | 0.106463 | 0.973 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 0.106463 | 0.973 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.139386 | 0.856 |
R-HSA-9005895 | Pervasive developmental disorders | 0.139386 | 0.856 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.139386 | 0.856 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.163284 | 0.787 |
R-HSA-9634597 | GPER1 signaling | 0.097657 | 1.010 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.147327 | 0.832 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.156705 | 0.805 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.186523 | 0.729 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.194126 | 0.712 |
R-HSA-5578775 | Ion homeostasis | 0.121683 | 0.915 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.171103 | 0.767 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.115546 | 0.937 |
R-HSA-69275 | G2/M Transition | 0.127936 | 0.893 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.131197 | 0.882 |
R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.098039 | 1.009 |
R-HSA-74749 | Signal attenuation | 0.114809 | 0.940 |
R-HSA-195721 | Signaling by WNT | 0.180000 | 0.745 |
R-HSA-74160 | Gene expression (Transcription) | 0.117763 | 0.929 |
R-HSA-8876725 | Protein methylation | 0.163284 | 0.787 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.146965 | 0.833 |
R-HSA-2028269 | Signaling by Hippo | 0.186523 | 0.729 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.140544 | 0.852 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.154089 | 0.812 |
R-HSA-9658195 | Leishmania infection | 0.154089 | 0.812 |
R-HSA-5218859 | Regulated Necrosis | 0.159980 | 0.796 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.163284 | 0.787 |
R-HSA-445717 | Aquaporin-mediated transport | 0.137357 | 0.862 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.166565 | 0.778 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.181595 | 0.741 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.146965 | 0.833 |
R-HSA-8978934 | Metabolism of cofactors | 0.169876 | 0.770 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.152362 | 0.817 |
R-HSA-163685 | Integration of energy metabolism | 0.174284 | 0.759 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.173197 | 0.761 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 0.186523 | 0.729 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.166565 | 0.778 |
R-HSA-373755 | Semaphorin interactions | 0.143746 | 0.842 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.130196 | 0.885 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.174284 | 0.759 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.137823 | 0.861 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.181231 | 0.742 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.121683 | 0.915 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.134834 | 0.870 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.200115 | 0.699 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.201659 | 0.695 |
R-HSA-449836 | Other interleukin signaling | 0.201659 | 0.695 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.201659 | 0.695 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.202500 | 0.694 |
R-HSA-69242 | S Phase | 0.204899 | 0.688 |
R-HSA-9675108 | Nervous system development | 0.206626 | 0.685 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.209121 | 0.680 |
R-HSA-72312 | rRNA processing | 0.212539 | 0.673 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.216514 | 0.665 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.216514 | 0.665 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.216514 | 0.665 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.216514 | 0.665 |
R-HSA-1500620 | Meiosis | 0.217180 | 0.663 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.220610 | 0.656 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.220782 | 0.656 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.221871 | 0.654 |
R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.223839 | 0.650 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.224044 | 0.650 |
R-HSA-156902 | Peptide chain elongation | 0.230924 | 0.637 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.231095 | 0.636 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.231095 | 0.636 |
R-HSA-877300 | Interferon gamma signaling | 0.231695 | 0.635 |
R-HSA-112310 | Neurotransmitter release cycle | 0.237818 | 0.624 |
R-HSA-977068 | Termination of O-glycan biosynthesis | 0.238284 | 0.623 |
R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.238284 | 0.623 |
R-HSA-8854691 | Interleukin-20 family signaling | 0.238284 | 0.623 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.241270 | 0.617 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.244724 | 0.611 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.245407 | 0.610 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.245407 | 0.610 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.245407 | 0.610 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.245407 | 0.610 |
R-HSA-429947 | Deadenylation of mRNA | 0.245407 | 0.610 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.245407 | 0.610 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.245407 | 0.610 |
R-HSA-74752 | Signaling by Insulin receptor | 0.248179 | 0.605 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.248179 | 0.605 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.252463 | 0.598 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.252463 | 0.598 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.252463 | 0.598 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.258556 | 0.587 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.259454 | 0.586 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.259454 | 0.586 |
R-HSA-525793 | Myogenesis | 0.259454 | 0.586 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.259454 | 0.586 |
R-HSA-5689901 | Metalloprotease DUBs | 0.259454 | 0.586 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.259454 | 0.586 |
R-HSA-9845614 | Sphingolipid catabolism | 0.259454 | 0.586 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.260626 | 0.584 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.262016 | 0.582 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.262016 | 0.582 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.262016 | 0.582 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.264121 | 0.578 |
R-HSA-418555 | G alpha (s) signalling events | 0.264121 | 0.578 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.265478 | 0.576 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.265478 | 0.576 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.265478 | 0.576 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.265478 | 0.576 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.266379 | 0.574 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.266379 | 0.574 |
R-HSA-157579 | Telomere Maintenance | 0.268939 | 0.570 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.268939 | 0.570 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.269164 | 0.570 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.269164 | 0.570 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.272400 | 0.565 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.273240 | 0.563 |
R-HSA-77387 | Insulin receptor recycling | 0.273240 | 0.563 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.273240 | 0.563 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.273240 | 0.563 |
R-HSA-5610787 | Hedgehog 'off' state | 0.279320 | 0.554 |
R-HSA-9615710 | Late endosomal microautophagy | 0.280038 | 0.553 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.280038 | 0.553 |
R-HSA-418360 | Platelet calcium homeostasis | 0.280038 | 0.553 |
R-HSA-2408557 | Selenocysteine synthesis | 0.282779 | 0.549 |
R-HSA-9020702 | Interleukin-1 signaling | 0.282779 | 0.549 |
R-HSA-168255 | Influenza Infection | 0.284355 | 0.546 |
R-HSA-73894 | DNA Repair | 0.285552 | 0.544 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.286236 | 0.543 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.286772 | 0.542 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.286772 | 0.542 |
R-HSA-192823 | Viral mRNA Translation | 0.289692 | 0.538 |
R-HSA-199991 | Membrane Trafficking | 0.292173 | 0.534 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.293145 | 0.533 |
R-HSA-399719 | Trafficking of AMPA receptors | 0.293444 | 0.532 |
R-HSA-5694530 | Cargo concentration in the ER | 0.293444 | 0.532 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.294524 | 0.531 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.300054 | 0.523 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.300054 | 0.523 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.305696 | 0.515 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.306602 | 0.513 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.306602 | 0.513 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.306602 | 0.513 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.306936 | 0.513 |
R-HSA-983712 | Ion channel transport | 0.309822 | 0.509 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.310377 | 0.508 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.310377 | 0.508 |
R-HSA-2672351 | Stimuli-sensing channels | 0.310377 | 0.508 |
R-HSA-597592 | Post-translational protein modification | 0.311273 | 0.507 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.313090 | 0.504 |
R-HSA-1482788 | Acyl chain remodelling of PC | 0.313090 | 0.504 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.313090 | 0.504 |
R-HSA-189483 | Heme degradation | 0.313090 | 0.504 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.319517 | 0.496 |
R-HSA-5205647 | Mitophagy | 0.319517 | 0.496 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.324103 | 0.489 |
R-HSA-1482839 | Acyl chain remodelling of PE | 0.325885 | 0.487 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.325885 | 0.487 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.330970 | 0.480 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.332193 | 0.479 |
R-HSA-8853659 | RET signaling | 0.332193 | 0.479 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.334352 | 0.476 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.337759 | 0.471 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.338443 | 0.471 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.342284 | 0.466 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.343029 | 0.465 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.344557 | 0.463 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.344557 | 0.463 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.344634 | 0.463 |
R-HSA-376176 | Signaling by ROBO receptors | 0.345581 | 0.461 |
R-HSA-9640148 | Infection with Enterobacteria | 0.345581 | 0.461 |
R-HSA-9007101 | Rab regulation of trafficking | 0.347948 | 0.458 |
R-HSA-9648002 | RAS processing | 0.350768 | 0.455 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.350768 | 0.455 |
R-HSA-201556 | Signaling by ALK | 0.350768 | 0.455 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.351334 | 0.454 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.356845 | 0.448 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.356845 | 0.448 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.356845 | 0.448 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.356845 | 0.448 |
R-HSA-5260271 | Diseases of Immune System | 0.356845 | 0.448 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.356845 | 0.448 |
R-HSA-8982491 | Glycogen metabolism | 0.356845 | 0.448 |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.356845 | 0.448 |
R-HSA-68875 | Mitotic Prophase | 0.358086 | 0.446 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.362866 | 0.440 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.362866 | 0.440 |
R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.362866 | 0.440 |
R-HSA-6811438 | Intra-Golgi traffic | 0.368830 | 0.433 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.368830 | 0.433 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.368830 | 0.433 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.368830 | 0.433 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.373586 | 0.428 |
R-HSA-418594 | G alpha (i) signalling events | 0.373807 | 0.427 |
R-HSA-165159 | MTOR signalling | 0.374739 | 0.426 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.374739 | 0.426 |
R-HSA-5653656 | Vesicle-mediated transport | 0.375014 | 0.426 |
R-HSA-69206 | G1/S Transition | 0.378186 | 0.422 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.380593 | 0.420 |
R-HSA-156581 | Methylation | 0.386393 | 0.413 |
R-HSA-774815 | Nucleosome assembly | 0.392138 | 0.407 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.392138 | 0.407 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.392138 | 0.407 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.397830 | 0.400 |
R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.397830 | 0.400 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.397830 | 0.400 |
R-HSA-1474165 | Reproduction | 0.398024 | 0.400 |
R-HSA-5576891 | Cardiac conduction | 0.401303 | 0.397 |
R-HSA-449147 | Signaling by Interleukins | 0.403122 | 0.395 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.403470 | 0.394 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.403470 | 0.394 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.404573 | 0.393 |
R-HSA-212436 | Generic Transcription Pathway | 0.404905 | 0.393 |
R-HSA-5620924 | Intraflagellar transport | 0.409056 | 0.388 |
R-HSA-9031628 | NGF-stimulated transcription | 0.409056 | 0.388 |
R-HSA-425410 | Metal ion SLC transporters | 0.409056 | 0.388 |
R-HSA-109704 | PI3K Cascade | 0.420075 | 0.377 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.420796 | 0.376 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.424014 | 0.373 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.425507 | 0.371 |
R-HSA-2514856 | The phototransduction cascade | 0.425507 | 0.371 |
R-HSA-9948299 | Ribosome-associated quality control | 0.427222 | 0.369 |
R-HSA-5358351 | Signaling by Hedgehog | 0.427222 | 0.369 |
R-HSA-1643685 | Disease | 0.428766 | 0.368 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.430888 | 0.366 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.430888 | 0.366 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.430888 | 0.366 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.430888 | 0.366 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.436220 | 0.360 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.436220 | 0.360 |
R-HSA-445355 | Smooth Muscle Contraction | 0.436220 | 0.360 |
R-HSA-8956320 | Nucleotide biosynthesis | 0.436220 | 0.360 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.436792 | 0.360 |
R-HSA-422475 | Axon guidance | 0.438771 | 0.358 |
R-HSA-157118 | Signaling by NOTCH | 0.441125 | 0.355 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.443125 | 0.353 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.446735 | 0.350 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.451919 | 0.345 |
R-HSA-75893 | TNF signaling | 0.451919 | 0.345 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.455671 | 0.341 |
R-HSA-112399 | IRS-mediated signalling | 0.457055 | 0.340 |
R-HSA-5621480 | Dectin-2 family | 0.457055 | 0.340 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.457055 | 0.340 |
R-HSA-6798695 | Neutrophil degranulation | 0.465907 | 0.332 |
R-HSA-9033241 | Peroxisomal protein import | 0.467184 | 0.331 |
R-HSA-180786 | Extension of Telomeres | 0.467184 | 0.331 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.467184 | 0.331 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.468056 | 0.330 |
R-HSA-388396 | GPCR downstream signalling | 0.470417 | 0.328 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.472178 | 0.326 |
R-HSA-983189 | Kinesins | 0.472178 | 0.326 |
R-HSA-379724 | tRNA Aminoacylation | 0.472178 | 0.326 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.472178 | 0.326 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.474186 | 0.324 |
R-HSA-446652 | Interleukin-1 family signaling | 0.474186 | 0.324 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.477125 | 0.321 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.477125 | 0.321 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.477125 | 0.321 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.480273 | 0.319 |
R-HSA-186797 | Signaling by PDGF | 0.482026 | 0.317 |
R-HSA-1266738 | Developmental Biology | 0.482904 | 0.316 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.486882 | 0.313 |
R-HSA-2428924 | IGF1R signaling cascade | 0.491692 | 0.308 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.492319 | 0.308 |
R-HSA-9711097 | Cellular response to starvation | 0.492319 | 0.308 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.496457 | 0.304 |
R-HSA-9006936 | Signaling by TGFB family members | 0.498276 | 0.303 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.510057 | 0.292 |
R-HSA-913709 | O-linked glycosylation of mucins | 0.510489 | 0.292 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.510489 | 0.292 |
R-HSA-9824446 | Viral Infection Pathways | 0.515221 | 0.288 |
R-HSA-392499 | Metabolism of proteins | 0.515370 | 0.288 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.519628 | 0.284 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.519628 | 0.284 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.519628 | 0.284 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.524133 | 0.281 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.524133 | 0.281 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.524133 | 0.281 |
R-HSA-189445 | Metabolism of porphyrins | 0.524133 | 0.281 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.528596 | 0.277 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.528596 | 0.277 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.533018 | 0.273 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.535900 | 0.271 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.537399 | 0.270 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.537399 | 0.270 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.537399 | 0.270 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.539975 | 0.268 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.541515 | 0.266 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.541738 | 0.266 |
R-HSA-5663205 | Infectious disease | 0.544480 | 0.264 |
R-HSA-216083 | Integrin cell surface interactions | 0.554516 | 0.256 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.555481 | 0.255 |
R-HSA-2559583 | Cellular Senescence | 0.558080 | 0.253 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.566940 | 0.246 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.570675 | 0.244 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.571005 | 0.243 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.575031 | 0.240 |
R-HSA-372790 | Signaling by GPCR | 0.583773 | 0.234 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.594607 | 0.226 |
R-HSA-9645723 | Diseases of programmed cell death | 0.598414 | 0.223 |
R-HSA-202424 | Downstream TCR signaling | 0.605920 | 0.218 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.609621 | 0.215 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.610206 | 0.215 |
R-HSA-72766 | Translation | 0.611422 | 0.214 |
R-HSA-391251 | Protein folding | 0.616919 | 0.210 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.617612 | 0.209 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.617612 | 0.209 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.620518 | 0.207 |
R-HSA-168256 | Immune System | 0.634029 | 0.198 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.634578 | 0.198 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.641413 | 0.193 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.641413 | 0.193 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.641413 | 0.193 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.641413 | 0.193 |
R-HSA-397014 | Muscle contraction | 0.641523 | 0.193 |
R-HSA-3214847 | HATs acetylate histones | 0.644782 | 0.191 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.654703 | 0.184 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.657949 | 0.182 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.664349 | 0.178 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.664349 | 0.178 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.667505 | 0.176 |
R-HSA-418346 | Platelet homeostasis | 0.670631 | 0.174 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.670631 | 0.174 |
R-HSA-5683057 | MAPK family signaling cascades | 0.671330 | 0.173 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.673014 | 0.172 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.673728 | 0.172 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.673728 | 0.172 |
R-HSA-211000 | Gene Silencing by RNA | 0.673728 | 0.172 |
R-HSA-1280218 | Adaptive Immune System | 0.675555 | 0.170 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.676795 | 0.170 |
R-HSA-5419276 | Mitochondrial translation termination | 0.679835 | 0.168 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.679835 | 0.168 |
R-HSA-202403 | TCR signaling | 0.682845 | 0.166 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.682845 | 0.166 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.682845 | 0.166 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.691710 | 0.160 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.691710 | 0.160 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.700329 | 0.155 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.703148 | 0.153 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.708708 | 0.150 |
R-HSA-2980736 | Peptide hormone metabolism | 0.708708 | 0.150 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.714164 | 0.146 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.714164 | 0.146 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.722159 | 0.141 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.722159 | 0.141 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.724774 | 0.140 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.724774 | 0.140 |
R-HSA-2132295 | MHC class II antigen presentation | 0.724774 | 0.140 |
R-HSA-6809371 | Formation of the cornified envelope | 0.727365 | 0.138 |
R-HSA-168249 | Innate Immune System | 0.728717 | 0.137 |
R-HSA-5688426 | Deubiquitination | 0.731134 | 0.136 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.732474 | 0.135 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.732904 | 0.135 |
R-HSA-913531 | Interferon Signaling | 0.732904 | 0.135 |
R-HSA-114608 | Platelet degranulation | 0.737488 | 0.132 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.739960 | 0.131 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.751977 | 0.124 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.754313 | 0.122 |
R-HSA-5173105 | O-linked glycosylation | 0.765671 | 0.116 |
R-HSA-5368287 | Mitochondrial translation | 0.767879 | 0.115 |
R-HSA-109582 | Hemostasis | 0.770854 | 0.113 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.782768 | 0.106 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.787671 | 0.104 |
R-HSA-2187338 | Visual phototransduction | 0.788855 | 0.103 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.790846 | 0.102 |
R-HSA-166520 | Signaling by NTRKs | 0.790846 | 0.102 |
R-HSA-9758941 | Gastrulation | 0.792818 | 0.101 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.794772 | 0.100 |
R-HSA-1483257 | Phospholipid metabolism | 0.796807 | 0.099 |
R-HSA-9609507 | Protein localization | 0.800525 | 0.097 |
R-HSA-1989781 | PPARA activates gene expression | 0.804270 | 0.095 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.807946 | 0.093 |
R-HSA-5689880 | Ub-specific processing proteases | 0.836547 | 0.078 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.836547 | 0.078 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.836547 | 0.078 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.839620 | 0.076 |
R-HSA-3781865 | Diseases of glycosylation | 0.852755 | 0.069 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.862227 | 0.064 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.868620 | 0.061 |
R-HSA-428157 | Sphingolipid metabolism | 0.874718 | 0.058 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.877455 | 0.057 |
R-HSA-6805567 | Keratinization | 0.881666 | 0.055 |
R-HSA-418990 | Adherens junctions interactions | 0.894434 | 0.048 |
R-HSA-8951664 | Neddylation | 0.897406 | 0.047 |
R-HSA-15869 | Metabolism of nucleotides | 0.911064 | 0.040 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.913570 | 0.039 |
R-HSA-421270 | Cell-cell junction organization | 0.922914 | 0.035 |
R-HSA-416476 | G alpha (q) signalling events | 0.931906 | 0.031 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.938107 | 0.028 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.940428 | 0.027 |
R-HSA-446728 | Cell junction organization | 0.940428 | 0.027 |
R-HSA-1500931 | Cell-Cell communication | 0.958583 | 0.018 |
R-HSA-382551 | Transport of small molecules | 0.961512 | 0.017 |
R-HSA-1474244 | Extracellular matrix organization | 0.964127 | 0.016 |
R-HSA-211859 | Biological oxidations | 0.964987 | 0.015 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.967407 | 0.014 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.981153 | 0.008 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.983990 | 0.007 |
R-HSA-5668914 | Diseases of metabolism | 0.985885 | 0.006 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.989228 | 0.005 |
R-HSA-556833 | Metabolism of lipids | 0.999732 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999952 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999995 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.864 | 0.213 | 2 | 0.846 |
CLK3 |
0.855 | 0.205 | 1 | 0.818 |
CDC7 |
0.849 | 0.089 | 1 | 0.827 |
MOS |
0.849 | 0.143 | 1 | 0.875 |
NDR2 |
0.848 | 0.100 | -3 | 0.838 |
MTOR |
0.848 | 0.156 | 1 | 0.769 |
PIM3 |
0.846 | 0.071 | -3 | 0.843 |
GCN2 |
0.845 | -0.030 | 2 | 0.790 |
PRPK |
0.845 | -0.038 | -1 | 0.774 |
RAF1 |
0.845 | 0.038 | 1 | 0.826 |
TBK1 |
0.843 | -0.001 | 1 | 0.744 |
IKKB |
0.842 | -0.039 | -2 | 0.795 |
CAMK2G |
0.842 | 0.022 | 2 | 0.797 |
CAMK1B |
0.841 | 0.029 | -3 | 0.849 |
DSTYK |
0.841 | 0.045 | 2 | 0.852 |
CDKL1 |
0.840 | 0.069 | -3 | 0.796 |
BMPR2 |
0.839 | -0.026 | -2 | 0.919 |
PKN3 |
0.839 | 0.057 | -3 | 0.816 |
NDR1 |
0.839 | 0.057 | -3 | 0.827 |
IKKE |
0.839 | -0.021 | 1 | 0.739 |
PRKD1 |
0.839 | 0.060 | -3 | 0.803 |
RSK2 |
0.838 | 0.080 | -3 | 0.762 |
NLK |
0.838 | 0.010 | 1 | 0.809 |
PIM1 |
0.838 | 0.105 | -3 | 0.783 |
MST4 |
0.838 | 0.109 | 2 | 0.806 |
PDHK4 |
0.837 | -0.153 | 1 | 0.838 |
KIS |
0.837 | 0.091 | 1 | 0.696 |
LATS2 |
0.837 | 0.044 | -5 | 0.760 |
ULK2 |
0.836 | -0.090 | 2 | 0.751 |
SRPK1 |
0.836 | 0.079 | -3 | 0.756 |
NUAK2 |
0.836 | 0.063 | -3 | 0.819 |
IKKA |
0.835 | 0.044 | -2 | 0.787 |
WNK1 |
0.835 | 0.023 | -2 | 0.881 |
P90RSK |
0.834 | 0.048 | -3 | 0.771 |
FAM20C |
0.834 | 0.072 | 2 | 0.575 |
PKCD |
0.834 | 0.104 | 2 | 0.743 |
NEK6 |
0.834 | -0.002 | -2 | 0.917 |
ATR |
0.834 | -0.027 | 1 | 0.807 |
MARK4 |
0.834 | 0.070 | 4 | 0.797 |
PRKD2 |
0.833 | 0.050 | -3 | 0.750 |
NIK |
0.833 | 0.004 | -3 | 0.869 |
TGFBR2 |
0.832 | -0.007 | -2 | 0.851 |
PDHK1 |
0.832 | -0.143 | 1 | 0.849 |
RSK3 |
0.832 | 0.047 | -3 | 0.764 |
SKMLCK |
0.832 | 0.030 | -2 | 0.877 |
PKN2 |
0.831 | 0.043 | -3 | 0.819 |
CAMLCK |
0.831 | 0.005 | -2 | 0.875 |
CAMK2B |
0.831 | 0.087 | 2 | 0.775 |
GRK6 |
0.830 | 0.021 | 1 | 0.790 |
ERK5 |
0.830 | -0.025 | 1 | 0.750 |
AMPKA1 |
0.830 | 0.019 | -3 | 0.832 |
P70S6KB |
0.830 | 0.032 | -3 | 0.784 |
RIPK3 |
0.830 | -0.080 | 3 | 0.744 |
TSSK1 |
0.830 | 0.053 | -3 | 0.849 |
NEK7 |
0.830 | -0.087 | -3 | 0.794 |
LATS1 |
0.829 | 0.122 | -3 | 0.854 |
TSSK2 |
0.829 | 0.022 | -5 | 0.846 |
MLK1 |
0.829 | -0.071 | 2 | 0.778 |
DAPK2 |
0.829 | -0.004 | -3 | 0.847 |
GRK5 |
0.829 | -0.101 | -3 | 0.867 |
NIM1 |
0.828 | 0.101 | 3 | 0.749 |
BMPR1B |
0.828 | 0.131 | 1 | 0.716 |
CAMK2D |
0.828 | 0.002 | -3 | 0.811 |
CDKL5 |
0.828 | 0.017 | -3 | 0.782 |
HIPK4 |
0.828 | 0.013 | 1 | 0.776 |
SRPK2 |
0.828 | 0.066 | -3 | 0.681 |
PKACG |
0.828 | 0.036 | -2 | 0.760 |
GRK1 |
0.827 | 0.024 | -2 | 0.792 |
MAPKAPK2 |
0.827 | 0.034 | -3 | 0.729 |
CHAK2 |
0.827 | -0.041 | -1 | 0.771 |
MAPKAPK3 |
0.827 | -0.021 | -3 | 0.758 |
ICK |
0.826 | 0.026 | -3 | 0.825 |
ATM |
0.826 | 0.008 | 1 | 0.746 |
HUNK |
0.826 | -0.108 | 2 | 0.801 |
GRK4 |
0.825 | -0.050 | -2 | 0.848 |
PLK1 |
0.825 | 0.038 | -2 | 0.907 |
AMPKA2 |
0.824 | 0.017 | -3 | 0.800 |
WNK3 |
0.824 | -0.200 | 1 | 0.807 |
CLK2 |
0.824 | 0.173 | -3 | 0.763 |
ULK1 |
0.824 | -0.153 | -3 | 0.786 |
TGFBR1 |
0.824 | 0.068 | -2 | 0.835 |
BCKDK |
0.824 | -0.131 | -1 | 0.728 |
JNK2 |
0.824 | 0.117 | 1 | 0.602 |
ALK4 |
0.824 | 0.035 | -2 | 0.860 |
AURC |
0.824 | 0.054 | -2 | 0.670 |
MASTL |
0.823 | -0.164 | -2 | 0.853 |
DLK |
0.823 | -0.085 | 1 | 0.793 |
NUAK1 |
0.823 | 0.030 | -3 | 0.777 |
ANKRD3 |
0.823 | -0.067 | 1 | 0.827 |
CDK8 |
0.823 | 0.035 | 1 | 0.646 |
PKR |
0.823 | 0.047 | 1 | 0.824 |
CLK4 |
0.823 | 0.081 | -3 | 0.763 |
GRK7 |
0.823 | 0.118 | 1 | 0.719 |
PAK1 |
0.823 | 0.008 | -2 | 0.809 |
PKACB |
0.823 | 0.092 | -2 | 0.701 |
MSK2 |
0.822 | 0.016 | -3 | 0.739 |
NEK9 |
0.822 | -0.103 | 2 | 0.795 |
RSK4 |
0.822 | 0.071 | -3 | 0.739 |
TTBK2 |
0.822 | -0.115 | 2 | 0.684 |
MNK2 |
0.822 | 0.027 | -2 | 0.823 |
PLK3 |
0.822 | 0.041 | 2 | 0.775 |
SRPK3 |
0.822 | 0.041 | -3 | 0.734 |
CAMK2A |
0.821 | 0.038 | 2 | 0.794 |
CAMK4 |
0.821 | -0.062 | -3 | 0.800 |
DNAPK |
0.821 | 0.083 | 1 | 0.695 |
ACVR2B |
0.820 | 0.079 | -2 | 0.860 |
JNK3 |
0.820 | 0.092 | 1 | 0.640 |
CLK1 |
0.820 | 0.085 | -3 | 0.733 |
ALK2 |
0.820 | 0.092 | -2 | 0.837 |
PRKD3 |
0.820 | 0.008 | -3 | 0.729 |
MSK1 |
0.820 | 0.051 | -3 | 0.743 |
DYRK2 |
0.819 | 0.052 | 1 | 0.663 |
PLK4 |
0.819 | 0.049 | 2 | 0.637 |
PAK3 |
0.819 | -0.042 | -2 | 0.814 |
SIK |
0.819 | 0.054 | -3 | 0.750 |
QSK |
0.819 | 0.048 | 4 | 0.767 |
IRE1 |
0.819 | -0.091 | 1 | 0.769 |
PKCB |
0.818 | 0.047 | 2 | 0.698 |
MEK1 |
0.818 | -0.016 | 2 | 0.809 |
RIPK1 |
0.818 | -0.177 | 1 | 0.781 |
CHK1 |
0.818 | 0.020 | -3 | 0.809 |
SGK3 |
0.818 | 0.082 | -3 | 0.745 |
PKCG |
0.818 | 0.033 | 2 | 0.706 |
ACVR2A |
0.818 | 0.050 | -2 | 0.846 |
MLK2 |
0.817 | -0.136 | 2 | 0.769 |
MELK |
0.817 | -0.045 | -3 | 0.782 |
YSK4 |
0.817 | -0.021 | 1 | 0.759 |
CDK18 |
0.816 | 0.081 | 1 | 0.583 |
MNK1 |
0.816 | 0.025 | -2 | 0.831 |
PRKX |
0.816 | 0.101 | -3 | 0.673 |
PKCA |
0.816 | 0.055 | 2 | 0.688 |
TLK2 |
0.816 | 0.004 | 1 | 0.775 |
QIK |
0.816 | -0.018 | -3 | 0.798 |
AURB |
0.816 | 0.026 | -2 | 0.673 |
CDK5 |
0.816 | 0.069 | 1 | 0.670 |
MLK3 |
0.816 | -0.054 | 2 | 0.704 |
BMPR1A |
0.815 | 0.127 | 1 | 0.711 |
CDK19 |
0.815 | 0.030 | 1 | 0.603 |
IRE2 |
0.815 | -0.071 | 2 | 0.719 |
CDK1 |
0.814 | 0.064 | 1 | 0.595 |
AURA |
0.814 | 0.039 | -2 | 0.645 |
MLK4 |
0.814 | -0.035 | 2 | 0.699 |
MARK3 |
0.814 | 0.039 | 4 | 0.730 |
CDK7 |
0.813 | -0.006 | 1 | 0.661 |
PAK6 |
0.813 | 0.004 | -2 | 0.734 |
PIM2 |
0.813 | 0.042 | -3 | 0.733 |
P38A |
0.813 | 0.050 | 1 | 0.674 |
DCAMKL1 |
0.813 | 0.041 | -3 | 0.776 |
PKCZ |
0.812 | -0.005 | 2 | 0.748 |
MARK2 |
0.812 | 0.019 | 4 | 0.695 |
PKCH |
0.812 | 0.004 | 2 | 0.687 |
AKT2 |
0.812 | 0.044 | -3 | 0.679 |
VRK2 |
0.812 | -0.193 | 1 | 0.848 |
PAK2 |
0.812 | -0.053 | -2 | 0.798 |
P38G |
0.811 | 0.072 | 1 | 0.516 |
MYLK4 |
0.811 | -0.012 | -2 | 0.797 |
BRAF |
0.811 | 0.005 | -4 | 0.801 |
PHKG1 |
0.811 | -0.065 | -3 | 0.813 |
NEK2 |
0.811 | -0.080 | 2 | 0.777 |
CDK13 |
0.810 | 0.014 | 1 | 0.635 |
SMG1 |
0.810 | -0.087 | 1 | 0.761 |
PRP4 |
0.809 | 0.043 | -3 | 0.789 |
CDK17 |
0.809 | 0.058 | 1 | 0.526 |
P38B |
0.809 | 0.058 | 1 | 0.604 |
DYRK4 |
0.809 | 0.083 | 1 | 0.596 |
PERK |
0.808 | -0.082 | -2 | 0.869 |
HIPK1 |
0.808 | 0.051 | 1 | 0.686 |
MEKK1 |
0.808 | -0.034 | 1 | 0.807 |
CAMK1G |
0.808 | -0.019 | -3 | 0.745 |
DYRK1A |
0.807 | 0.026 | 1 | 0.732 |
PKG2 |
0.807 | -0.008 | -2 | 0.688 |
TLK1 |
0.807 | -0.054 | -2 | 0.881 |
HIPK2 |
0.807 | 0.057 | 1 | 0.587 |
CHAK1 |
0.806 | -0.159 | 2 | 0.725 |
MEKK3 |
0.806 | -0.057 | 1 | 0.764 |
DCAMKL2 |
0.806 | -0.002 | -3 | 0.792 |
MARK1 |
0.806 | -0.009 | 4 | 0.754 |
BRSK1 |
0.806 | -0.076 | -3 | 0.782 |
HRI |
0.806 | -0.142 | -2 | 0.900 |
MEKK2 |
0.806 | -0.003 | 2 | 0.762 |
CDK16 |
0.806 | 0.089 | 1 | 0.551 |
CK2A2 |
0.806 | 0.135 | 1 | 0.694 |
ERK1 |
0.805 | 0.027 | 1 | 0.599 |
DRAK1 |
0.805 | -0.060 | 1 | 0.665 |
TAO3 |
0.805 | 0.063 | 1 | 0.777 |
ERK2 |
0.805 | -0.001 | 1 | 0.646 |
WNK4 |
0.805 | -0.083 | -2 | 0.872 |
ZAK |
0.805 | -0.052 | 1 | 0.769 |
MST3 |
0.804 | 0.056 | 2 | 0.807 |
CDK2 |
0.804 | -0.008 | 1 | 0.667 |
PKACA |
0.804 | 0.053 | -2 | 0.639 |
CDK12 |
0.804 | 0.020 | 1 | 0.608 |
CDK14 |
0.804 | 0.064 | 1 | 0.623 |
BRSK2 |
0.804 | -0.109 | -3 | 0.792 |
AKT1 |
0.803 | 0.048 | -3 | 0.691 |
PKCT |
0.803 | 0.007 | 2 | 0.689 |
CDK3 |
0.803 | 0.059 | 1 | 0.544 |
CDK9 |
0.802 | -0.002 | 1 | 0.639 |
GSK3A |
0.802 | 0.051 | 4 | 0.421 |
PASK |
0.802 | 0.018 | -3 | 0.843 |
MEK5 |
0.802 | -0.181 | 2 | 0.786 |
GAK |
0.802 | 0.060 | 1 | 0.793 |
DYRK1B |
0.802 | 0.049 | 1 | 0.611 |
SMMLCK |
0.802 | -0.019 | -3 | 0.799 |
P38D |
0.802 | 0.062 | 1 | 0.556 |
SNRK |
0.801 | -0.200 | 2 | 0.666 |
DYRK3 |
0.801 | 0.043 | 1 | 0.687 |
NEK5 |
0.801 | -0.089 | 1 | 0.800 |
GRK2 |
0.800 | -0.090 | -2 | 0.728 |
MAPKAPK5 |
0.800 | -0.129 | -3 | 0.698 |
IRAK4 |
0.800 | -0.120 | 1 | 0.783 |
PHKG2 |
0.800 | -0.049 | -3 | 0.775 |
P70S6K |
0.800 | -0.026 | -3 | 0.688 |
CAMK1D |
0.800 | 0.001 | -3 | 0.677 |
PLK2 |
0.800 | 0.061 | -3 | 0.846 |
MPSK1 |
0.799 | 0.029 | 1 | 0.770 |
HIPK3 |
0.799 | 0.002 | 1 | 0.698 |
SSTK |
0.799 | -0.063 | 4 | 0.760 |
CK1G1 |
0.799 | -0.006 | -3 | 0.604 |
CK1E |
0.799 | -0.026 | -3 | 0.577 |
GSK3B |
0.798 | -0.004 | 4 | 0.409 |
DAPK3 |
0.798 | 0.035 | -3 | 0.794 |
PINK1 |
0.798 | -0.168 | 1 | 0.820 |
ERK7 |
0.797 | 0.068 | 2 | 0.580 |
JNK1 |
0.797 | 0.059 | 1 | 0.585 |
PAK5 |
0.796 | -0.021 | -2 | 0.682 |
CDK10 |
0.796 | 0.056 | 1 | 0.607 |
PKCI |
0.796 | 0.003 | 2 | 0.725 |
SGK1 |
0.796 | 0.073 | -3 | 0.607 |
TAO2 |
0.795 | -0.033 | 2 | 0.796 |
TTBK1 |
0.795 | -0.152 | 2 | 0.605 |
MRCKA |
0.794 | 0.063 | -3 | 0.743 |
CK2A1 |
0.794 | 0.105 | 1 | 0.666 |
GCK |
0.793 | 0.051 | 1 | 0.757 |
MRCKB |
0.793 | 0.049 | -3 | 0.725 |
MST2 |
0.793 | 0.006 | 1 | 0.776 |
TNIK |
0.792 | 0.053 | 3 | 0.808 |
NEK8 |
0.792 | -0.131 | 2 | 0.782 |
PAK4 |
0.792 | -0.025 | -2 | 0.680 |
NEK11 |
0.792 | -0.095 | 1 | 0.773 |
CAMKK1 |
0.792 | -0.147 | -2 | 0.791 |
ROCK2 |
0.792 | 0.070 | -3 | 0.776 |
PDK1 |
0.791 | -0.056 | 1 | 0.789 |
PKCE |
0.791 | 0.022 | 2 | 0.690 |
HGK |
0.790 | 0.004 | 3 | 0.816 |
PDHK3_TYR |
0.790 | 0.211 | 4 | 0.873 |
MINK |
0.790 | 0.021 | 1 | 0.775 |
AKT3 |
0.790 | 0.040 | -3 | 0.621 |
LKB1 |
0.790 | -0.108 | -3 | 0.796 |
CHK2 |
0.790 | -0.003 | -3 | 0.625 |
CK1D |
0.790 | -0.031 | -3 | 0.527 |
DAPK1 |
0.790 | 0.009 | -3 | 0.773 |
EEF2K |
0.789 | -0.023 | 3 | 0.794 |
IRAK1 |
0.789 | -0.251 | -1 | 0.677 |
TAK1 |
0.789 | -0.033 | 1 | 0.819 |
PKN1 |
0.789 | -0.009 | -3 | 0.697 |
MAP3K15 |
0.789 | -0.006 | 1 | 0.756 |
MEKK6 |
0.787 | -0.050 | 1 | 0.762 |
GRK3 |
0.787 | -0.079 | -2 | 0.679 |
NEK4 |
0.787 | -0.104 | 1 | 0.781 |
CAMK1A |
0.787 | -0.004 | -3 | 0.652 |
CK1A2 |
0.786 | -0.034 | -3 | 0.525 |
LRRK2 |
0.786 | -0.091 | 2 | 0.818 |
HPK1 |
0.786 | 0.021 | 1 | 0.748 |
LOK |
0.785 | -0.053 | -2 | 0.812 |
MST1 |
0.785 | -0.026 | 1 | 0.767 |
VRK1 |
0.785 | -0.127 | 2 | 0.817 |
DMPK1 |
0.785 | 0.073 | -3 | 0.748 |
CDK6 |
0.784 | 0.019 | 1 | 0.611 |
CAMKK2 |
0.784 | -0.176 | -2 | 0.777 |
MAK |
0.784 | 0.067 | -2 | 0.724 |
KHS2 |
0.784 | 0.071 | 1 | 0.768 |
SBK |
0.783 | 0.022 | -3 | 0.563 |
SLK |
0.783 | -0.043 | -2 | 0.762 |
KHS1 |
0.783 | 0.042 | 1 | 0.766 |
PDHK4_TYR |
0.782 | 0.119 | 2 | 0.854 |
NEK1 |
0.782 | -0.086 | 1 | 0.787 |
TTK |
0.781 | 0.058 | -2 | 0.894 |
YSK1 |
0.781 | 0.005 | 2 | 0.766 |
CDK4 |
0.781 | 0.006 | 1 | 0.599 |
MEK2 |
0.780 | -0.138 | 2 | 0.773 |
BUB1 |
0.779 | -0.003 | -5 | 0.812 |
MAP2K4_TYR |
0.778 | 0.040 | -1 | 0.801 |
MAP2K6_TYR |
0.778 | 0.066 | -1 | 0.789 |
ROCK1 |
0.778 | 0.042 | -3 | 0.742 |
TESK1_TYR |
0.777 | -0.077 | 3 | 0.847 |
MAP2K7_TYR |
0.777 | -0.071 | 2 | 0.823 |
CRIK |
0.776 | 0.036 | -3 | 0.688 |
MOK |
0.776 | 0.017 | 1 | 0.679 |
BMPR2_TYR |
0.776 | 0.027 | -1 | 0.785 |
PDHK1_TYR |
0.776 | 0.005 | -1 | 0.795 |
STK33 |
0.776 | -0.158 | 2 | 0.604 |
OSR1 |
0.776 | -0.015 | 2 | 0.764 |
PKMYT1_TYR |
0.775 | 0.008 | 3 | 0.820 |
ALPHAK3 |
0.775 | 0.028 | -1 | 0.694 |
RIPK2 |
0.773 | -0.239 | 1 | 0.746 |
PINK1_TYR |
0.773 | -0.112 | 1 | 0.821 |
PBK |
0.772 | -0.069 | 1 | 0.720 |
LIMK2_TYR |
0.771 | -0.053 | -3 | 0.865 |
HASPIN |
0.771 | -0.025 | -1 | 0.653 |
RET |
0.770 | -0.097 | 1 | 0.795 |
TXK |
0.769 | 0.096 | 1 | 0.770 |
NEK3 |
0.769 | -0.150 | 1 | 0.759 |
EPHA6 |
0.769 | -0.038 | -1 | 0.744 |
PKG1 |
0.768 | -0.050 | -2 | 0.606 |
CSF1R |
0.767 | -0.048 | 3 | 0.761 |
YANK3 |
0.767 | -0.052 | 2 | 0.415 |
ASK1 |
0.767 | -0.072 | 1 | 0.754 |
MST1R |
0.766 | -0.130 | 3 | 0.784 |
BIKE |
0.766 | -0.029 | 1 | 0.668 |
MYO3B |
0.766 | -0.024 | 2 | 0.777 |
YES1 |
0.766 | -0.012 | -1 | 0.756 |
MYO3A |
0.766 | -0.019 | 1 | 0.771 |
TYK2 |
0.765 | -0.134 | 1 | 0.803 |
EPHB4 |
0.765 | -0.061 | -1 | 0.718 |
LIMK1_TYR |
0.765 | -0.155 | 2 | 0.801 |
TYRO3 |
0.764 | -0.145 | 3 | 0.767 |
DDR1 |
0.763 | -0.145 | 4 | 0.799 |
ABL2 |
0.763 | -0.061 | -1 | 0.730 |
ROS1 |
0.762 | -0.127 | 3 | 0.749 |
JAK2 |
0.762 | -0.134 | 1 | 0.803 |
FER |
0.762 | -0.084 | 1 | 0.821 |
TAO1 |
0.762 | -0.076 | 1 | 0.727 |
SRMS |
0.761 | -0.022 | 1 | 0.796 |
BLK |
0.761 | 0.041 | -1 | 0.740 |
JAK3 |
0.761 | -0.106 | 1 | 0.765 |
INSRR |
0.761 | -0.064 | 3 | 0.742 |
EPHA4 |
0.761 | -0.019 | 2 | 0.775 |
FGR |
0.760 | -0.098 | 1 | 0.784 |
FGFR2 |
0.760 | -0.106 | 3 | 0.787 |
ITK |
0.760 | -0.029 | -1 | 0.707 |
LCK |
0.759 | -0.018 | -1 | 0.729 |
KIT |
0.759 | -0.078 | 3 | 0.762 |
HCK |
0.758 | -0.089 | -1 | 0.730 |
ABL1 |
0.757 | -0.094 | -1 | 0.729 |
FLT3 |
0.757 | -0.107 | 3 | 0.751 |
BMX |
0.756 | -0.025 | -1 | 0.638 |
EPHB1 |
0.755 | -0.090 | 1 | 0.789 |
EPHB2 |
0.755 | -0.046 | -1 | 0.695 |
NEK10_TYR |
0.755 | -0.085 | 1 | 0.698 |
TNK2 |
0.755 | -0.107 | 3 | 0.721 |
TEC |
0.755 | -0.036 | -1 | 0.669 |
TNK1 |
0.755 | -0.099 | 3 | 0.747 |
STLK3 |
0.755 | -0.133 | 1 | 0.747 |
FYN |
0.754 | 0.022 | -1 | 0.711 |
TEK |
0.754 | -0.138 | 3 | 0.708 |
EPHB3 |
0.754 | -0.094 | -1 | 0.697 |
PDGFRB |
0.754 | -0.163 | 3 | 0.772 |
KDR |
0.754 | -0.117 | 3 | 0.735 |
FGFR1 |
0.753 | -0.146 | 3 | 0.752 |
AXL |
0.753 | -0.131 | 3 | 0.757 |
AAK1 |
0.753 | 0.020 | 1 | 0.564 |
TNNI3K_TYR |
0.752 | -0.070 | 1 | 0.817 |
MERTK |
0.752 | -0.110 | 3 | 0.748 |
JAK1 |
0.751 | -0.070 | 1 | 0.742 |
MET |
0.750 | -0.113 | 3 | 0.753 |
FGFR3 |
0.750 | -0.105 | 3 | 0.764 |
FLT1 |
0.749 | -0.093 | -1 | 0.725 |
BTK |
0.748 | -0.173 | -1 | 0.683 |
FRK |
0.747 | -0.083 | -1 | 0.738 |
PTK6 |
0.747 | -0.172 | -1 | 0.644 |
CK1A |
0.747 | -0.080 | -3 | 0.448 |
EPHA7 |
0.746 | -0.091 | 2 | 0.769 |
LYN |
0.746 | -0.078 | 3 | 0.682 |
LTK |
0.745 | -0.159 | 3 | 0.725 |
DDR2 |
0.745 | -0.065 | 3 | 0.733 |
NTRK1 |
0.745 | -0.182 | -1 | 0.711 |
PDGFRA |
0.745 | -0.246 | 3 | 0.762 |
ALK |
0.745 | -0.174 | 3 | 0.702 |
FLT4 |
0.744 | -0.161 | 3 | 0.736 |
EPHA3 |
0.743 | -0.147 | 2 | 0.746 |
ERBB2 |
0.743 | -0.170 | 1 | 0.730 |
EPHA1 |
0.743 | -0.149 | 3 | 0.738 |
EPHA5 |
0.742 | -0.066 | 2 | 0.762 |
WEE1_TYR |
0.742 | -0.159 | -1 | 0.670 |
EGFR |
0.742 | -0.067 | 1 | 0.642 |
PTK2B |
0.741 | -0.083 | -1 | 0.690 |
MATK |
0.741 | -0.120 | -1 | 0.670 |
SRC |
0.741 | -0.071 | -1 | 0.720 |
INSR |
0.740 | -0.171 | 3 | 0.719 |
EPHA8 |
0.740 | -0.078 | -1 | 0.692 |
FGFR4 |
0.739 | -0.079 | -1 | 0.673 |
PTK2 |
0.737 | -0.023 | -1 | 0.683 |
NTRK2 |
0.737 | -0.239 | 3 | 0.725 |
CSK |
0.736 | -0.138 | 2 | 0.764 |
NTRK3 |
0.735 | -0.177 | -1 | 0.658 |
SYK |
0.735 | -0.022 | -1 | 0.660 |
CK1G3 |
0.732 | -0.069 | -3 | 0.406 |
EPHA2 |
0.731 | -0.084 | -1 | 0.659 |
YANK2 |
0.730 | -0.087 | 2 | 0.419 |
IGF1R |
0.727 | -0.150 | 3 | 0.658 |
ERBB4 |
0.726 | -0.076 | 1 | 0.636 |
MUSK |
0.719 | -0.202 | 1 | 0.616 |
FES |
0.714 | -0.164 | -1 | 0.623 |
ZAP70 |
0.711 | -0.075 | -1 | 0.606 |
CK1G2 |
0.710 | -0.089 | -3 | 0.509 |