Motif 669 (n=118)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| M0QYT0 | None | S103 | ochoa | RRM domain-containing protein | None |
| O15014 | ZNF609 | S467 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15085 | ARHGEF11 | S547 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43318 | MAP3K7 | S367 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43399 | TPD52L2 | S186 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O60673 | REV3L | S1724 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75069 | TMCC2 | S75 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75151 | PHF2 | S899 | ochoa|psp | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75152 | ZC3H11A | S543 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O94986 | CEP152 | S1618 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95810 | CAVIN2 | S247 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P02545 | LMNA | S212 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P07814 | EPRS1 | S1336 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P09429 | HMGB1 | S53 | psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P10636 | MAPT | S318 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P13010 | XRCC5 | S577 | ochoa|psp | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13489 | RNH1 | S178 | ochoa | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
| P14618 | PKM | S77 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P14618 | PKM | S100 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P14866 | HNRNPL | S486 | ochoa | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| P26045 | PTPN3 | S335 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P29374 | ARID4A | S455 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30519 | HMOX2 | Y268 | ochoa | Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form] | [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}. |
| P33176 | KIF5B | S175 | psp | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P35348 | ADRA1A | S401 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P36578 | RPL4 | S55 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P40926 | MDH2 | S250 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P45973 | CBX5 | S95 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46100 | ATRX | S1236 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P51608 | MECP2 | S116 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P52179 | MYOM1 | S992 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P62280 | RPS11 | S67 | ochoa | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62714 | PPP2CB | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| Q01082 | SPTBN1 | S903 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q05209 | PTPN12 | S449 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08945 | SSRP1 | S688 | psp | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q08J23 | NSUN2 | S721 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q12840 | KIF5A | S176 | ochoa | Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {ECO:0000250|UniProtKB:P33175, ECO:0000250|UniProtKB:Q6QLM7}. |
| Q12982 | BNIP2 | S114 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 | Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. |
| Q13206 | DDX10 | S831 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13247 | SRSF6 | S301 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13480 | GAB1 | S439 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13547 | HDAC1 | S85 | ochoa | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q14686 | NCOA6 | T2020 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14766 | LTBP1 | S1414 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14980 | NUMA1 | S1789 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q4AC94 | C2CD3 | S466 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q52LW3 | ARHGAP29 | S519 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53EL6 | PDCD4 | S46 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5T0F9 | CC2D1B | S751 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
| Q6P995 | FAM171B | S504 | ochoa | Protein FAM171B | None |
| Q6PJF5 | RHBDF2 | S90 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6PJT7 | ZC3H14 | S475 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6PKG0 | LARP1 | S824 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PL18 | ATAD2 | S141 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZV73 | FGD6 | S1164 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7L2Z9 | CENPQ | S50 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q86T65 | DAAM2 | S656 | ochoa | Disheveled-associated activator of morphogenesis 2 | Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676). {ECO:0000250|UniProtKB:Q80U19, ECO:0000269|PubMed:33232676}. |
| Q8IVL1 | NAV2 | S1059 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWT6 | LRRC8A | S198 | ochoa | Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) | Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:30095067). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). Acts as a key factor in NLRP3 inflammasome activation by modulating itaconate efflux and mitochondria function (PubMed:39909992). {ECO:0000250|UniProtKB:Q80WG5, ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:29371604, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122, ECO:0000269|PubMed:39909992}. |
| Q8N3K9 | CMYA5 | S2479 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8NCE0 | TSEN2 | S21 | ochoa | tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. {ECO:0000269|PubMed:15109492}. |
| Q8NG31 | KNL1 | S402 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NI27 | THOC2 | S1448 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8WUB8 | PHF10 | S323 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WXI7 | MUC16 | S6973 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WYH8 | ING5 | S123 | ochoa | Inhibitor of growth protein 5 (p28ING5) | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}. |
| Q8WYP5 | AHCTF1 | S1914 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92769 | HDAC2 | S86 | ochoa | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
| Q92994 | BRF1 | S548 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96RT1 | ERBIN | S826 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96T58 | SPEN | S1824 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99490 | AGAP2 | S929 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99541 | PLIN2 | S224 | ochoa | Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. {ECO:0000269|PubMed:34077757}. |
| Q99590 | SCAF11 | S1058 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99700 | ATXN2 | S479 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BSQ5 | CCM2 | S384 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S152 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BXB5 | OSBPL10 | S510 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BXL7 | CARD11 | S652 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BYW2 | SETD2 | S1885 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZL4 | PPP1R12C | S327 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0C2 | TNKS1BP1 | S1666 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY6 | LAT2 | S106 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H4L7 | SMARCAD1 | S239 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H5J8 | TAF1D | S138 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9HCG8 | CWC22 | S831 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9NRZ9 | HELLS | S119 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NUM4 | TMEM106B | S33 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NUQ6 | SPATS2L | S369 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NUQ6 | SPATS2L | S493 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NUQ6 | SPATS2L | S518 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVH1 | DNAJC11 | S27 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NVI1 | FANCI | S1116 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NYF8 | BCLAF1 | S450 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYZ1 | TVP23B | S184 | ochoa | Golgi apparatus membrane protein TVP23 homolog B | None |
| Q9UDY2 | TJP2 | S461 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UJ78 | ZMYM5 | S158 | ochoa | Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) | Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}. |
| Q9UPQ0 | LIMCH1 | S657 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPQ3 | AGAP1 | S607 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) | GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
| Q9UPQ7 | PDZRN3 | S584 | ochoa | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}. |
| Q9Y297 | BTRC | S82 | psp | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}. |
| Q9Y4G8 | RAPGEF2 | S935 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y520 | PRRC2C | S21 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| O15111 | CHUK | S579 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P26373 | RPL13 | S97 | Sugiyama | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| O15020 | SPTBN2 | S442 | Sugiyama | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| P11277 | SPTB | S439 | Sugiyama | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| Q01082 | SPTBN1 | S439 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| P35222 | CTNNB1 | S179 | PSP | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P17948 | FLT1 | S1125 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| Q9BRX5 | GINS3 | S85 | Sugiyama | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| O60282 | KIF5C | S176 | SIGNOR | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}. |
| P51813 | BMX | S381 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P62913 | RPL11 | S59 | Sugiyama | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| Q9H2M9 | RAB3GAP2 | S455 | Sugiyama | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
| Q7KZF4 | SND1 | S720 | Sugiyama | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000001 | 5.935 |
| R-HSA-75153 | Apoptotic execution phase | 0.000007 | 5.132 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.000012 | 4.934 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000020 | 4.706 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000048 | 4.316 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000138 | 3.860 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.000195 | 3.710 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.000296 | 3.529 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.000357 | 3.448 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.000357 | 3.448 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.000357 | 3.448 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.000357 | 3.448 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.000357 | 3.448 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.000357 | 3.448 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.000357 | 3.448 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.000357 | 3.448 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000168 | 3.775 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000218 | 3.662 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.000343 | 3.464 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.000343 | 3.464 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.000343 | 3.464 |
| R-HSA-450294 | MAP kinase activation | 0.000316 | 3.501 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.000586 | 3.232 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.000549 | 3.261 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.000567 | 3.246 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.000618 | 3.209 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.000618 | 3.209 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.000592 | 3.228 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.000497 | 3.303 |
| R-HSA-448424 | Interleukin-17 signaling | 0.000549 | 3.261 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.000672 | 3.173 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.000672 | 3.173 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.000700 | 3.155 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.000782 | 3.107 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.000791 | 3.102 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.000938 | 3.028 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.000963 | 3.017 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.000963 | 3.017 |
| R-HSA-68882 | Mitotic Anaphase | 0.000909 | 3.042 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000933 | 3.030 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000848 | 3.072 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.001078 | 2.967 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.001078 | 2.967 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.001215 | 2.915 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.001215 | 2.915 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001254 | 2.902 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001254 | 2.902 |
| R-HSA-1640170 | Cell Cycle | 0.001242 | 2.906 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.001334 | 2.875 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001390 | 2.857 |
| R-HSA-156902 | Peptide chain elongation | 0.001439 | 2.842 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.001642 | 2.785 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.001629 | 2.788 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.001602 | 2.795 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.001645 | 2.784 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.001715 | 2.766 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.001789 | 2.747 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.002136 | 2.670 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.002028 | 2.693 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.002112 | 2.675 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.002112 | 2.675 |
| R-HSA-68877 | Mitotic Prometaphase | 0.002195 | 2.659 |
| R-HSA-68886 | M Phase | 0.002225 | 2.653 |
| R-HSA-8953854 | Metabolism of RNA | 0.002271 | 2.644 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.002573 | 2.590 |
| R-HSA-983189 | Kinesins | 0.002712 | 2.567 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.002673 | 2.573 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.002748 | 2.561 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.002821 | 2.550 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.002821 | 2.550 |
| R-HSA-264876 | Insulin processing | 0.002821 | 2.550 |
| R-HSA-192823 | Viral mRNA Translation | 0.002882 | 2.540 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.002911 | 2.536 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.002991 | 2.524 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.003302 | 2.481 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.003302 | 2.481 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.003456 | 2.461 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.003269 | 2.486 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.003580 | 2.446 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.003580 | 2.446 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.003596 | 2.444 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.003707 | 2.431 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.004178 | 2.379 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.004405 | 2.356 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.004490 | 2.348 |
| R-HSA-390696 | Adrenoceptors | 0.003973 | 2.401 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.003973 | 2.401 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.004082 | 2.389 |
| R-HSA-109581 | Apoptosis | 0.004307 | 2.366 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.004540 | 2.343 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.004703 | 2.328 |
| R-HSA-9675108 | Nervous system development | 0.004976 | 2.303 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.005001 | 2.301 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.005001 | 2.301 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.006332 | 2.198 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.006332 | 2.198 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.006332 | 2.198 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.006255 | 2.204 |
| R-HSA-4839744 | Signaling by APC mutants | 0.006332 | 2.198 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.005844 | 2.233 |
| R-HSA-68875 | Mitotic Prophase | 0.005668 | 2.247 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.006208 | 2.207 |
| R-HSA-9833482 | PKR-mediated signaling | 0.006695 | 2.174 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.008180 | 2.087 |
| R-HSA-202670 | ERKs are inactivated | 0.007229 | 2.141 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.007229 | 2.141 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.007229 | 2.141 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.007229 | 2.141 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.008382 | 2.077 |
| R-HSA-74160 | Gene expression (Transcription) | 0.007695 | 2.114 |
| R-HSA-4839726 | Chromatin organization | 0.007877 | 2.104 |
| R-HSA-422475 | Axon guidance | 0.008377 | 2.077 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.008497 | 2.071 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.008853 | 2.053 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.008878 | 2.052 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.010225 | 1.990 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.011433 | 1.942 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.011349 | 1.945 |
| R-HSA-202424 | Downstream TCR signaling | 0.010000 | 2.000 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.010241 | 1.990 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.009338 | 2.030 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.010355 | 1.985 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.011349 | 1.945 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.011996 | 1.921 |
| R-HSA-5357801 | Programmed Cell Death | 0.012147 | 1.916 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.012507 | 1.903 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.012572 | 1.901 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.012970 | 1.887 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.012970 | 1.887 |
| R-HSA-72187 | mRNA 3'-end processing | 0.014403 | 1.842 |
| R-HSA-70171 | Glycolysis | 0.014645 | 1.834 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.014710 | 1.832 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.016628 | 1.779 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.016628 | 1.779 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.016628 | 1.779 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.016628 | 1.779 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.016628 | 1.779 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.019019 | 1.721 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.016273 | 1.789 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.016376 | 1.786 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.015084 | 1.821 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.016273 | 1.789 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.017066 | 1.768 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.019985 | 1.699 |
| R-HSA-202403 | TCR signaling | 0.019936 | 1.700 |
| R-HSA-177929 | Signaling by EGFR | 0.017066 | 1.768 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.017623 | 1.754 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.019130 | 1.718 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.018392 | 1.735 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.018392 | 1.735 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.015743 | 1.803 |
| R-HSA-9711097 | Cellular response to starvation | 0.016823 | 1.774 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.016273 | 1.789 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.019985 | 1.699 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.015843 | 1.800 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.017675 | 1.753 |
| R-HSA-73887 | Death Receptor Signaling | 0.015394 | 1.813 |
| R-HSA-198753 | ERK/MAPK targets | 0.020459 | 1.689 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.020718 | 1.684 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.020755 | 1.683 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.021541 | 1.667 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.021944 | 1.659 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.022072 | 1.656 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.022516 | 1.648 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.023473 | 1.629 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.024839 | 1.605 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.024839 | 1.605 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.032982 | 1.482 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.032982 | 1.482 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.032982 | 1.482 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.032982 | 1.482 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.032982 | 1.482 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.032982 | 1.482 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.032982 | 1.482 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.032982 | 1.482 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.032982 | 1.482 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.032982 | 1.482 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.032982 | 1.482 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.031736 | 1.498 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.031736 | 1.498 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.033508 | 1.475 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.033508 | 1.475 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.026656 | 1.574 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.029344 | 1.532 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.034241 | 1.465 |
| R-HSA-525793 | Myogenesis | 0.030003 | 1.523 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.029344 | 1.532 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.032982 | 1.482 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.033508 | 1.475 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.035318 | 1.452 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.031255 | 1.505 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.026144 | 1.583 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.035318 | 1.452 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.031736 | 1.498 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.028287 | 1.548 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.024839 | 1.605 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.028412 | 1.546 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.030945 | 1.509 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.028412 | 1.546 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.028668 | 1.543 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.029344 | 1.532 |
| R-HSA-180024 | DARPP-32 events | 0.035318 | 1.452 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.030364 | 1.518 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.028412 | 1.546 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.035318 | 1.452 |
| R-HSA-70326 | Glucose metabolism | 0.025041 | 1.601 |
| R-HSA-168255 | Influenza Infection | 0.026269 | 1.581 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.025041 | 1.601 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.035708 | 1.447 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.036311 | 1.440 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.036311 | 1.440 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.037164 | 1.430 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.037164 | 1.430 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.037950 | 1.421 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.038444 | 1.415 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.038444 | 1.415 |
| R-HSA-182971 | EGFR downregulation | 0.039047 | 1.408 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.039841 | 1.400 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.039841 | 1.400 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.040640 | 1.391 |
| R-HSA-8865999 | MET activates PTPN11 | 0.041057 | 1.387 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.041389 | 1.383 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.042919 | 1.367 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.042919 | 1.367 |
| R-HSA-449147 | Signaling by Interleukins | 0.045954 | 1.338 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.046928 | 1.329 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.046928 | 1.329 |
| R-HSA-5673000 | RAF activation | 0.046928 | 1.329 |
| R-HSA-1643685 | Disease | 0.047693 | 1.322 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.048225 | 1.317 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.048982 | 1.310 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.050319 | 1.298 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.051068 | 1.292 |
| R-HSA-195721 | Signaling by WNT | 0.052222 | 1.282 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.057008 | 1.244 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.057513 | 1.240 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.057513 | 1.240 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.057513 | 1.240 |
| R-HSA-201556 | Signaling by ALK | 0.057513 | 1.240 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.057581 | 1.240 |
| R-HSA-9824446 | Viral Infection Pathways | 0.058262 | 1.235 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.059721 | 1.224 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.059721 | 1.224 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.059721 | 1.224 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.059721 | 1.224 |
| R-HSA-5260271 | Diseases of Immune System | 0.059721 | 1.224 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.059721 | 1.224 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.059721 | 1.224 |
| R-HSA-167169 | HIV Transcription Elongation | 0.059721 | 1.224 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.061578 | 1.211 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.061765 | 1.209 |
| R-HSA-72312 | rRNA processing | 0.061893 | 1.208 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.061959 | 1.208 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.064884 | 1.188 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.080441 | 1.095 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.080441 | 1.095 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.080441 | 1.095 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.088123 | 1.055 |
| R-HSA-8875656 | MET receptor recycling | 0.088123 | 1.055 |
| R-HSA-9613354 | Lipophagy | 0.095741 | 1.019 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.103296 | 0.986 |
| R-HSA-164843 | 2-LTR circle formation | 0.103296 | 0.986 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.110789 | 0.956 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.073555 | 1.133 |
| R-HSA-774815 | Nucleosome assembly | 0.073555 | 1.133 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.106488 | 0.973 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.111857 | 0.951 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.125574 | 0.901 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.114087 | 0.943 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.114087 | 0.943 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.114087 | 0.943 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.103296 | 0.986 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.108786 | 0.963 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.107830 | 0.967 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.125588 | 0.901 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.073555 | 1.133 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.064884 | 1.188 |
| R-HSA-176974 | Unwinding of DNA | 0.095741 | 1.019 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.103296 | 0.986 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.125588 | 0.901 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.090836 | 1.042 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.093394 | 1.030 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.123135 | 0.910 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.095741 | 1.019 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.064884 | 1.188 |
| R-HSA-1221632 | Meiotic synapsis | 0.093394 | 1.030 |
| R-HSA-4641265 | Repression of WNT target genes | 0.125588 | 0.901 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.064884 | 1.188 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.125588 | 0.901 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.125588 | 0.901 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.070228 | 1.153 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.103830 | 0.984 |
| R-HSA-190236 | Signaling by FGFR | 0.064530 | 1.190 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.110789 | 0.956 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.107803 | 0.967 |
| R-HSA-162592 | Integration of provirus | 0.118219 | 0.927 |
| R-HSA-9843745 | Adipogenesis | 0.126826 | 0.897 |
| R-HSA-73886 | Chromosome Maintenance | 0.105307 | 0.978 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.064884 | 1.188 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.110789 | 0.956 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.110789 | 0.956 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.111857 | 0.951 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.073159 | 1.136 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.078985 | 1.102 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.078985 | 1.102 |
| R-HSA-69275 | G2/M Transition | 0.094745 | 1.023 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.097293 | 1.012 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.064884 | 1.188 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.103296 | 0.986 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.090226 | 1.045 |
| R-HSA-212436 | Generic Transcription Pathway | 0.067145 | 1.173 |
| R-HSA-1280218 | Adaptive Immune System | 0.112755 | 0.948 |
| R-HSA-69236 | G1 Phase | 0.071183 | 1.148 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.071183 | 1.148 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.125588 | 0.901 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.080821 | 1.092 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.095741 | 1.019 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.122799 | 0.911 |
| R-HSA-75893 | TNF signaling | 0.101192 | 0.995 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.071183 | 1.148 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.085160 | 1.070 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.064224 | 1.192 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.083291 | 1.079 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.111857 | 0.951 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.111857 | 0.951 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.111857 | 0.951 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.111857 | 0.951 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.065934 | 1.181 |
| R-HSA-373760 | L1CAM interactions | 0.096811 | 1.014 |
| R-HSA-69206 | G1/S Transition | 0.114087 | 0.943 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.125574 | 0.901 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.111857 | 0.951 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.128364 | 0.892 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.132895 | 0.876 |
| R-HSA-167172 | Transcription of the HIV genome | 0.133988 | 0.873 |
| R-HSA-109582 | Hemostasis | 0.139498 | 0.855 |
| R-HSA-162582 | Signal Transduction | 0.139617 | 0.855 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.140142 | 0.853 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.140142 | 0.853 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.140142 | 0.853 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.140142 | 0.853 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.140142 | 0.853 |
| R-HSA-418990 | Adherens junctions interactions | 0.140671 | 0.852 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.145398 | 0.837 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.147329 | 0.832 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.147329 | 0.832 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.147329 | 0.832 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.147329 | 0.832 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.147329 | 0.832 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.147329 | 0.832 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.147329 | 0.832 |
| R-HSA-4086398 | Ca2+ pathway | 0.148282 | 0.829 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.151177 | 0.821 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.151739 | 0.819 |
| R-HSA-1500931 | Cell-Cell communication | 0.152989 | 0.815 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.154456 | 0.811 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.154456 | 0.811 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.154456 | 0.811 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.154456 | 0.811 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.154456 | 0.811 |
| R-HSA-162906 | HIV Infection | 0.154511 | 0.811 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.156080 | 0.807 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.157001 | 0.804 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.157001 | 0.804 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.159700 | 0.797 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.161524 | 0.792 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.161524 | 0.792 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.161710 | 0.791 |
| R-HSA-166520 | Signaling by NTRKs | 0.163728 | 0.786 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.167787 | 0.775 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.168533 | 0.773 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.168533 | 0.773 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.168533 | 0.773 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.168533 | 0.773 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.168533 | 0.773 |
| R-HSA-2028269 | Signaling by Hippo | 0.168533 | 0.773 |
| R-HSA-180292 | GAB1 signalosome | 0.175484 | 0.756 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.175484 | 0.756 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.175484 | 0.756 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.175991 | 0.755 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.177698 | 0.750 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.177698 | 0.750 |
| R-HSA-72766 | Translation | 0.177840 | 0.750 |
| R-HSA-1989781 | PPARA activates gene expression | 0.178060 | 0.749 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.179945 | 0.745 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.180690 | 0.743 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.182218 | 0.739 |
| R-HSA-162587 | HIV Life Cycle | 0.182218 | 0.739 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.182378 | 0.739 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.182378 | 0.739 |
| R-HSA-9834899 | Specification of the neural plate border | 0.182378 | 0.739 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.182378 | 0.739 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.182378 | 0.739 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.182378 | 0.739 |
| R-HSA-1500620 | Meiosis | 0.183689 | 0.736 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.183689 | 0.736 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.188503 | 0.725 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.189214 | 0.723 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.189214 | 0.723 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.189214 | 0.723 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.189214 | 0.723 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.189214 | 0.723 |
| R-HSA-373753 | Nephrin family interactions | 0.189214 | 0.723 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.189709 | 0.722 |
| R-HSA-70268 | Pyruvate metabolism | 0.192729 | 0.715 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.192729 | 0.715 |
| R-HSA-421270 | Cell-cell junction organization | 0.193716 | 0.713 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.195756 | 0.708 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.195994 | 0.708 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.195994 | 0.708 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.195994 | 0.708 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.195994 | 0.708 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.195994 | 0.708 |
| R-HSA-210991 | Basigin interactions | 0.195994 | 0.708 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.195994 | 0.708 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.198789 | 0.702 |
| R-HSA-199991 | Membrane Trafficking | 0.200311 | 0.698 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.201827 | 0.695 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.202253 | 0.694 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.202717 | 0.693 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.202717 | 0.693 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.202717 | 0.693 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.202717 | 0.693 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.207920 | 0.682 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.209384 | 0.679 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.209384 | 0.679 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.209384 | 0.679 |
| R-HSA-9679506 | SARS-CoV Infections | 0.210208 | 0.677 |
| R-HSA-72306 | tRNA processing | 0.212004 | 0.674 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.215996 | 0.666 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.215996 | 0.666 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.220162 | 0.657 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.222554 | 0.653 |
| R-HSA-429947 | Deadenylation of mRNA | 0.222554 | 0.653 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.222554 | 0.653 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.222554 | 0.653 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.229056 | 0.640 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.229056 | 0.640 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.229056 | 0.640 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.229056 | 0.640 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.229056 | 0.640 |
| R-HSA-9839394 | TGFBR3 expression | 0.229056 | 0.640 |
| R-HSA-3214842 | HDMs demethylate histones | 0.229056 | 0.640 |
| R-HSA-9830364 | Formation of the nephric duct | 0.229056 | 0.640 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.229384 | 0.639 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.235505 | 0.628 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.235505 | 0.628 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.235505 | 0.628 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.235546 | 0.628 |
| R-HSA-446728 | Cell junction organization | 0.241046 | 0.618 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.241900 | 0.616 |
| R-HSA-8949613 | Cristae formation | 0.241900 | 0.616 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.241900 | 0.616 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.241900 | 0.616 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.241900 | 0.616 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.248242 | 0.605 |
| R-HSA-5620971 | Pyroptosis | 0.248242 | 0.605 |
| R-HSA-111885 | Opioid Signalling | 0.250990 | 0.600 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.254532 | 0.594 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.254532 | 0.594 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.254532 | 0.594 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.254532 | 0.594 |
| R-HSA-418346 | Platelet homeostasis | 0.260273 | 0.585 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.260769 | 0.584 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.260769 | 0.584 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.260769 | 0.584 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.260769 | 0.584 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.265163 | 0.576 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.266464 | 0.574 |
| R-HSA-5663205 | Infectious disease | 0.266638 | 0.574 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.266955 | 0.574 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.273089 | 0.564 |
| R-HSA-1538133 | G0 and Early G1 | 0.273089 | 0.564 |
| R-HSA-69190 | DNA strand elongation | 0.273089 | 0.564 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.273089 | 0.564 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.279172 | 0.554 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.279172 | 0.554 |
| R-HSA-9733709 | Cardiogenesis | 0.279172 | 0.554 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.283265 | 0.548 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.285204 | 0.545 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.285204 | 0.545 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.285204 | 0.545 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.285204 | 0.545 |
| R-HSA-189483 | Heme degradation | 0.285204 | 0.545 |
| R-HSA-72172 | mRNA Splicing | 0.290084 | 0.537 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.291187 | 0.536 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.291187 | 0.536 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.291187 | 0.536 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.297119 | 0.527 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.297119 | 0.527 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.297119 | 0.527 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.297119 | 0.527 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.300473 | 0.522 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.303003 | 0.519 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.303003 | 0.519 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.303003 | 0.519 |
| R-HSA-8853659 | RET signaling | 0.303003 | 0.519 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.303003 | 0.519 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.303555 | 0.518 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.308837 | 0.510 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.308837 | 0.510 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.308837 | 0.510 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.310605 | 0.508 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.311953 | 0.506 |
| R-HSA-8875878 | MET promotes cell motility | 0.314624 | 0.502 |
| R-HSA-1566948 | Elastic fibre formation | 0.314624 | 0.502 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.318927 | 0.496 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.320362 | 0.494 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.320362 | 0.494 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.320362 | 0.494 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.326052 | 0.487 |
| R-HSA-194138 | Signaling by VEGF | 0.328119 | 0.484 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.331695 | 0.479 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.331695 | 0.479 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.331695 | 0.479 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.331695 | 0.479 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.331695 | 0.479 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.337274 | 0.472 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.337291 | 0.472 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.337291 | 0.472 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.337291 | 0.472 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.337291 | 0.472 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.337291 | 0.472 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.342841 | 0.465 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.342841 | 0.465 |
| R-HSA-168249 | Innate Immune System | 0.343029 | 0.465 |
| R-HSA-1474165 | Reproduction | 0.346393 | 0.460 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.348344 | 0.458 |
| R-HSA-9909396 | Circadian clock | 0.352451 | 0.453 |
| R-HSA-373752 | Netrin-1 signaling | 0.353802 | 0.451 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.353802 | 0.451 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.359214 | 0.445 |
| R-HSA-9824272 | Somitogenesis | 0.359214 | 0.445 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.359214 | 0.445 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.359214 | 0.445 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.359214 | 0.445 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.364581 | 0.438 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.364581 | 0.438 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.364581 | 0.438 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.364581 | 0.438 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.364581 | 0.438 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.367507 | 0.435 |
| R-HSA-163685 | Integration of energy metabolism | 0.367507 | 0.435 |
| R-HSA-2262752 | Cellular responses to stress | 0.373169 | 0.428 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.373945 | 0.427 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.375183 | 0.426 |
| R-HSA-6807070 | PTEN Regulation | 0.376478 | 0.424 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.376478 | 0.424 |
| R-HSA-73893 | DNA Damage Bypass | 0.380417 | 0.420 |
| R-HSA-9766229 | Degradation of CDH1 | 0.380417 | 0.420 |
| R-HSA-1266738 | Developmental Biology | 0.384474 | 0.415 |
| R-HSA-109704 | PI3K Cascade | 0.385608 | 0.414 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.385608 | 0.414 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.388357 | 0.411 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.393594 | 0.405 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.395861 | 0.402 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.400924 | 0.397 |
| R-HSA-72649 | Translation initiation complex formation | 0.405944 | 0.392 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.405944 | 0.392 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.410923 | 0.386 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.411812 | 0.385 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.415860 | 0.381 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.415860 | 0.381 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.415860 | 0.381 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.415860 | 0.381 |
| R-HSA-69306 | DNA Replication | 0.420496 | 0.376 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.420756 | 0.376 |
| R-HSA-112399 | IRS-mediated signalling | 0.420756 | 0.376 |
| R-HSA-5621480 | Dectin-2 family | 0.420756 | 0.376 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.420756 | 0.376 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.425612 | 0.371 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.430427 | 0.366 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.430427 | 0.366 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.435036 | 0.361 |
| R-HSA-379724 | tRNA Aminoacylation | 0.435202 | 0.361 |
| R-HSA-913531 | Interferon Signaling | 0.439859 | 0.357 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.439937 | 0.357 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.439937 | 0.357 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.444633 | 0.352 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.444633 | 0.352 |
| R-HSA-9707616 | Heme signaling | 0.444633 | 0.352 |
| R-HSA-186797 | Signaling by PDGF | 0.444633 | 0.352 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.444633 | 0.352 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.447682 | 0.349 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.449290 | 0.347 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.449290 | 0.347 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.449290 | 0.347 |
| R-HSA-373755 | Semaphorin interactions | 0.449290 | 0.347 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.449290 | 0.347 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.453908 | 0.343 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.453908 | 0.343 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.458488 | 0.339 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.463029 | 0.334 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.463029 | 0.334 |
| R-HSA-9830369 | Kidney development | 0.467533 | 0.330 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.467533 | 0.330 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.471999 | 0.326 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.471999 | 0.326 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.471999 | 0.326 |
| R-HSA-5218859 | Regulated Necrosis | 0.471999 | 0.326 |
| R-HSA-392499 | Metabolism of proteins | 0.476526 | 0.322 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.476632 | 0.322 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.485175 | 0.314 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.485175 | 0.314 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.485175 | 0.314 |
| R-HSA-189445 | Metabolism of porphyrins | 0.485175 | 0.314 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.489495 | 0.310 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.493778 | 0.306 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.493778 | 0.306 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.498025 | 0.303 |
| R-HSA-380287 | Centrosome maturation | 0.502238 | 0.299 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.502238 | 0.299 |
| R-HSA-917937 | Iron uptake and transport | 0.502238 | 0.299 |
| R-HSA-9659379 | Sensory processing of sound | 0.518739 | 0.285 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.518739 | 0.285 |
| R-HSA-6806834 | Signaling by MET | 0.522778 | 0.282 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.522778 | 0.282 |
| R-HSA-5617833 | Cilium Assembly | 0.524270 | 0.280 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.526784 | 0.278 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.546319 | 0.263 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.546319 | 0.263 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.549462 | 0.260 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.550129 | 0.260 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.553907 | 0.257 |
| R-HSA-9663891 | Selective autophagy | 0.557653 | 0.254 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.557653 | 0.254 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.567597 | 0.246 |
| R-HSA-6798695 | Neutrophil degranulation | 0.570924 | 0.243 |
| R-HSA-168256 | Immune System | 0.572980 | 0.242 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.575923 | 0.240 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.583019 | 0.234 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.583019 | 0.234 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.585296 | 0.233 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.593443 | 0.227 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.593443 | 0.227 |
| R-HSA-157579 | Telomere Maintenance | 0.596860 | 0.224 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.596860 | 0.224 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.600248 | 0.222 |
| R-HSA-3214847 | HATs acetylate histones | 0.603608 | 0.219 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.606940 | 0.217 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.613521 | 0.212 |
| R-HSA-1483255 | PI Metabolism | 0.613521 | 0.212 |
| R-HSA-73894 | DNA Repair | 0.620085 | 0.208 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.623188 | 0.205 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.623188 | 0.205 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.629499 | 0.201 |
| R-HSA-69239 | Synthesis of DNA | 0.632615 | 0.199 |
| R-HSA-157118 | Signaling by NOTCH | 0.642824 | 0.192 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.656624 | 0.183 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.661153 | 0.180 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.662379 | 0.179 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.668038 | 0.175 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.679075 | 0.168 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.684456 | 0.165 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.687113 | 0.163 |
| R-HSA-416476 | G alpha (q) signalling events | 0.690085 | 0.161 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.720928 | 0.142 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.724402 | 0.140 |
| R-HSA-5173105 | O-linked glycosylation | 0.726725 | 0.139 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.729029 | 0.137 |
| R-HSA-1632852 | Macroautophagy | 0.735824 | 0.133 |
| R-HSA-1483257 | Phospholipid metabolism | 0.743444 | 0.129 |
| R-HSA-69242 | S Phase | 0.753129 | 0.123 |
| R-HSA-9758941 | Gastrulation | 0.755211 | 0.122 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.759324 | 0.120 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.763368 | 0.117 |
| R-HSA-9612973 | Autophagy | 0.769308 | 0.114 |
| R-HSA-388396 | GPCR downstream signalling | 0.801227 | 0.096 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.801965 | 0.096 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.801965 | 0.096 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.801965 | 0.096 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.805297 | 0.094 |
| R-HSA-611105 | Respiratory electron transport | 0.810192 | 0.091 |
| R-HSA-3781865 | Diseases of glycosylation | 0.819617 | 0.086 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.846506 | 0.072 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.859018 | 0.066 |
| R-HSA-372790 | Signaling by GPCR | 0.864692 | 0.063 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.865341 | 0.063 |
| R-HSA-8951664 | Neddylation | 0.869411 | 0.061 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.874853 | 0.058 |
| R-HSA-418594 | G alpha (i) signalling events | 0.876571 | 0.057 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.886044 | 0.053 |
| R-HSA-8939211 | ESR-mediated signaling | 0.886044 | 0.053 |
| R-HSA-5688426 | Deubiquitination | 0.902254 | 0.045 |
| R-HSA-597592 | Post-translational protein modification | 0.907020 | 0.042 |
| R-HSA-9658195 | Leishmania infection | 0.921709 | 0.035 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.921709 | 0.035 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.922375 | 0.035 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.945340 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 0.945806 | 0.024 |
| R-HSA-1474244 | Extracellular matrix organization | 0.948961 | 0.023 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.961214 | 0.017 |
| R-HSA-500792 | GPCR ligand binding | 0.965623 | 0.015 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.969510 | 0.013 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.971293 | 0.013 |
| R-HSA-5668914 | Diseases of metabolism | 0.977831 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.984440 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.991481 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.996480 | 0.002 |
| R-HSA-1430728 | Metabolism | 0.999454 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999983 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.854 | 0.079 | 2 | 0.780 |
CLK3 |
0.854 | 0.225 | 1 | 0.823 |
CDC7 |
0.853 | 0.260 | 1 | 0.913 |
PIM3 |
0.850 | 0.195 | -3 | 0.829 |
FAM20C |
0.849 | 0.305 | 2 | 0.739 |
MOS |
0.847 | 0.232 | 1 | 0.907 |
NDR2 |
0.847 | 0.129 | -3 | 0.834 |
RSK2 |
0.845 | 0.202 | -3 | 0.777 |
PIM1 |
0.842 | 0.210 | -3 | 0.785 |
P70S6KB |
0.841 | 0.229 | -3 | 0.798 |
NDR1 |
0.840 | 0.137 | -3 | 0.830 |
CAMK2G |
0.840 | 0.038 | 2 | 0.746 |
CAMK1B |
0.840 | 0.099 | -3 | 0.843 |
PRPK |
0.840 | -0.023 | -1 | 0.828 |
RAF1 |
0.838 | -0.019 | 1 | 0.827 |
IKKB |
0.837 | -0.048 | -2 | 0.795 |
DSTYK |
0.837 | -0.008 | 2 | 0.802 |
MST4 |
0.836 | 0.081 | 2 | 0.768 |
RSK3 |
0.835 | 0.164 | -3 | 0.769 |
SRPK1 |
0.835 | 0.109 | -3 | 0.756 |
PRKD2 |
0.835 | 0.134 | -3 | 0.783 |
CDKL1 |
0.835 | 0.086 | -3 | 0.792 |
PDHK4 |
0.835 | -0.146 | 1 | 0.823 |
MTOR |
0.834 | -0.098 | 1 | 0.755 |
P90RSK |
0.834 | 0.139 | -3 | 0.782 |
RSK4 |
0.834 | 0.227 | -3 | 0.757 |
BMPR2 |
0.834 | -0.020 | -2 | 0.923 |
BMPR1B |
0.834 | 0.238 | 1 | 0.856 |
GRK1 |
0.834 | 0.136 | -2 | 0.863 |
GCN2 |
0.833 | -0.117 | 2 | 0.674 |
CAMK2B |
0.833 | 0.150 | 2 | 0.778 |
NLK |
0.833 | 0.023 | 1 | 0.786 |
SRPK2 |
0.832 | 0.137 | -3 | 0.689 |
NUAK2 |
0.832 | 0.081 | -3 | 0.823 |
AMPKA1 |
0.832 | 0.112 | -3 | 0.838 |
MAPKAPK2 |
0.832 | 0.129 | -3 | 0.750 |
PKACG |
0.832 | 0.117 | -2 | 0.780 |
LATS2 |
0.832 | 0.065 | -5 | 0.717 |
ATR |
0.831 | -0.033 | 1 | 0.774 |
PKN3 |
0.830 | 0.037 | -3 | 0.814 |
CAMLCK |
0.830 | 0.086 | -2 | 0.873 |
NIK |
0.830 | 0.040 | -3 | 0.856 |
PRKD1 |
0.830 | 0.057 | -3 | 0.813 |
GRK6 |
0.830 | 0.089 | 1 | 0.838 |
TBK1 |
0.830 | -0.101 | 1 | 0.705 |
CAMK2D |
0.829 | 0.041 | -3 | 0.829 |
MARK4 |
0.829 | 0.035 | 4 | 0.872 |
WNK1 |
0.828 | 0.013 | -2 | 0.882 |
DAPK2 |
0.828 | 0.084 | -3 | 0.844 |
TGFBR2 |
0.828 | 0.016 | -2 | 0.851 |
SKMLCK |
0.828 | 0.029 | -2 | 0.872 |
MAPKAPK3 |
0.828 | 0.072 | -3 | 0.785 |
HIPK4 |
0.828 | 0.077 | 1 | 0.758 |
AMPKA2 |
0.828 | 0.113 | -3 | 0.818 |
AURC |
0.828 | 0.101 | -2 | 0.673 |
PIM2 |
0.828 | 0.230 | -3 | 0.752 |
SRPK3 |
0.828 | 0.112 | -3 | 0.724 |
CDKL5 |
0.827 | 0.072 | -3 | 0.787 |
GRK5 |
0.827 | -0.035 | -3 | 0.781 |
PKN2 |
0.826 | 0.031 | -3 | 0.818 |
IKKE |
0.826 | -0.122 | 1 | 0.703 |
CLK2 |
0.826 | 0.188 | -3 | 0.768 |
PDHK1 |
0.826 | -0.180 | 1 | 0.808 |
KIS |
0.826 | 0.048 | 1 | 0.662 |
CAMK2A |
0.825 | 0.101 | 2 | 0.757 |
ALK2 |
0.825 | 0.230 | -2 | 0.861 |
ERK5 |
0.825 | -0.009 | 1 | 0.772 |
PKACB |
0.825 | 0.134 | -2 | 0.698 |
IKKA |
0.824 | -0.027 | -2 | 0.776 |
ULK2 |
0.824 | -0.193 | 2 | 0.642 |
TGFBR1 |
0.824 | 0.120 | -2 | 0.852 |
NEK6 |
0.823 | -0.092 | -2 | 0.886 |
NEK7 |
0.823 | -0.150 | -3 | 0.794 |
PRKX |
0.823 | 0.156 | -3 | 0.702 |
BCKDK |
0.823 | -0.094 | -1 | 0.791 |
PAK1 |
0.822 | 0.057 | -2 | 0.798 |
PKCD |
0.822 | 0.027 | 2 | 0.653 |
ATM |
0.822 | 0.003 | 1 | 0.727 |
ALK4 |
0.822 | 0.081 | -2 | 0.882 |
MSK2 |
0.822 | 0.063 | -3 | 0.743 |
MLK1 |
0.822 | -0.127 | 2 | 0.681 |
RIPK3 |
0.822 | -0.102 | 3 | 0.679 |
BMPR1A |
0.821 | 0.237 | 1 | 0.861 |
HUNK |
0.821 | -0.110 | 2 | 0.692 |
GRK7 |
0.821 | 0.127 | 1 | 0.762 |
WNK3 |
0.821 | -0.110 | 1 | 0.778 |
MSK1 |
0.821 | 0.108 | -3 | 0.749 |
ICK |
0.820 | 0.027 | -3 | 0.822 |
LATS1 |
0.820 | 0.101 | -3 | 0.843 |
CLK4 |
0.820 | 0.106 | -3 | 0.768 |
PKR |
0.819 | 0.059 | 1 | 0.799 |
DLK |
0.819 | -0.102 | 1 | 0.805 |
CHAK2 |
0.819 | -0.084 | -1 | 0.798 |
ACVR2B |
0.819 | 0.131 | -2 | 0.856 |
GRK4 |
0.818 | -0.068 | -2 | 0.883 |
AKT2 |
0.818 | 0.126 | -3 | 0.701 |
P70S6K |
0.818 | 0.211 | -3 | 0.713 |
PAK3 |
0.817 | 0.026 | -2 | 0.803 |
TSSK2 |
0.817 | 0.008 | -5 | 0.731 |
MYLK4 |
0.817 | 0.079 | -2 | 0.795 |
QSK |
0.817 | 0.051 | 4 | 0.852 |
AURB |
0.817 | 0.080 | -2 | 0.674 |
BRSK1 |
0.817 | 0.056 | -3 | 0.795 |
CAMK4 |
0.817 | -0.010 | -3 | 0.809 |
SIK |
0.817 | 0.062 | -3 | 0.762 |
CLK1 |
0.817 | 0.108 | -3 | 0.754 |
PAK6 |
0.817 | 0.068 | -2 | 0.722 |
PRKD3 |
0.816 | 0.069 | -3 | 0.749 |
TSSK1 |
0.816 | 0.025 | -3 | 0.855 |
DYRK2 |
0.816 | 0.059 | 1 | 0.660 |
ACVR2A |
0.815 | 0.086 | -2 | 0.843 |
MELK |
0.815 | 0.028 | -3 | 0.810 |
MASTL |
0.815 | -0.243 | -2 | 0.876 |
PLK1 |
0.815 | -0.037 | -2 | 0.871 |
NEK9 |
0.815 | -0.162 | 2 | 0.706 |
NIM1 |
0.814 | -0.063 | 3 | 0.718 |
AURA |
0.814 | 0.058 | -2 | 0.639 |
TTBK2 |
0.814 | -0.102 | 2 | 0.582 |
SGK3 |
0.814 | 0.116 | -3 | 0.758 |
NUAK1 |
0.814 | 0.019 | -3 | 0.801 |
QIK |
0.814 | -0.022 | -3 | 0.812 |
PAK2 |
0.813 | 0.029 | -2 | 0.792 |
ULK1 |
0.813 | -0.214 | -3 | 0.767 |
PKG2 |
0.813 | 0.084 | -2 | 0.702 |
ANKRD3 |
0.812 | -0.182 | 1 | 0.804 |
MARK3 |
0.812 | 0.052 | 4 | 0.819 |
RIPK1 |
0.812 | -0.158 | 1 | 0.761 |
MLK2 |
0.812 | -0.150 | 2 | 0.695 |
MNK2 |
0.812 | -0.004 | -2 | 0.810 |
PLK3 |
0.812 | -0.006 | 2 | 0.692 |
CK2A2 |
0.812 | 0.214 | 1 | 0.753 |
DNAPK |
0.811 | 0.005 | 1 | 0.636 |
BRSK2 |
0.811 | 0.002 | -3 | 0.817 |
MARK2 |
0.811 | 0.044 | 4 | 0.784 |
YSK4 |
0.811 | -0.095 | 1 | 0.752 |
PKCB |
0.810 | -0.013 | 2 | 0.602 |
PKCA |
0.810 | -0.000 | 2 | 0.592 |
CDK8 |
0.810 | -0.026 | 1 | 0.633 |
PKCG |
0.810 | -0.017 | 2 | 0.593 |
CHK1 |
0.809 | 0.010 | -3 | 0.818 |
SMG1 |
0.809 | -0.021 | 1 | 0.715 |
MNK1 |
0.809 | 0.017 | -2 | 0.831 |
MEK1 |
0.808 | -0.145 | 2 | 0.720 |
HIPK1 |
0.808 | 0.094 | 1 | 0.671 |
CDK7 |
0.808 | -0.009 | 1 | 0.644 |
PHKG1 |
0.808 | -0.036 | -3 | 0.824 |
IRE1 |
0.808 | -0.124 | 1 | 0.749 |
PKACA |
0.808 | 0.104 | -2 | 0.643 |
HIPK2 |
0.808 | 0.078 | 1 | 0.576 |
MLK3 |
0.808 | -0.107 | 2 | 0.611 |
CAMK1G |
0.808 | 0.039 | -3 | 0.766 |
PASK |
0.807 | 0.078 | -3 | 0.824 |
PKCH |
0.807 | -0.021 | 2 | 0.567 |
JNK2 |
0.807 | 0.037 | 1 | 0.584 |
MARK1 |
0.807 | 0.026 | 4 | 0.831 |
BRAF |
0.807 | -0.007 | -4 | 0.810 |
DRAK1 |
0.806 | -0.035 | 1 | 0.714 |
NEK2 |
0.806 | -0.110 | 2 | 0.669 |
PRP4 |
0.806 | 0.065 | -3 | 0.751 |
TLK2 |
0.805 | -0.078 | 1 | 0.772 |
MAPKAPK5 |
0.805 | -0.031 | -3 | 0.720 |
JNK3 |
0.804 | 0.013 | 1 | 0.622 |
CDK1 |
0.804 | -0.000 | 1 | 0.593 |
DCAMKL1 |
0.804 | 0.038 | -3 | 0.788 |
CAMK1D |
0.804 | 0.095 | -3 | 0.722 |
AKT1 |
0.804 | 0.106 | -3 | 0.720 |
CDK19 |
0.804 | -0.026 | 1 | 0.592 |
MST3 |
0.804 | 0.008 | 2 | 0.713 |
IRE2 |
0.804 | -0.076 | 2 | 0.570 |
DYRK4 |
0.803 | 0.070 | 1 | 0.591 |
VRK2 |
0.803 | -0.261 | 1 | 0.830 |
DAPK3 |
0.802 | 0.135 | -3 | 0.802 |
SMMLCK |
0.802 | 0.048 | -3 | 0.808 |
CK2A1 |
0.802 | 0.183 | 1 | 0.722 |
MLK4 |
0.802 | -0.127 | 2 | 0.588 |
PKCZ |
0.802 | -0.080 | 2 | 0.634 |
CDK5 |
0.801 | -0.007 | 1 | 0.657 |
TAO3 |
0.801 | -0.020 | 1 | 0.766 |
P38A |
0.801 | -0.004 | 1 | 0.666 |
CDK18 |
0.800 | -0.001 | 1 | 0.561 |
SGK1 |
0.800 | 0.157 | -3 | 0.632 |
DYRK1A |
0.800 | 0.038 | 1 | 0.706 |
CDK13 |
0.800 | -0.040 | 1 | 0.613 |
PERK |
0.800 | -0.100 | -2 | 0.887 |
PAK5 |
0.799 | 0.035 | -2 | 0.671 |
GRK2 |
0.799 | -0.070 | -2 | 0.748 |
SNRK |
0.799 | -0.129 | 2 | 0.522 |
MRCKB |
0.798 | 0.150 | -3 | 0.750 |
DYRK1B |
0.798 | 0.064 | 1 | 0.612 |
CHAK1 |
0.798 | -0.163 | 2 | 0.609 |
DYRK3 |
0.798 | 0.079 | 1 | 0.674 |
P38B |
0.798 | 0.008 | 1 | 0.598 |
CDK9 |
0.798 | -0.028 | 1 | 0.617 |
MEK5 |
0.798 | -0.206 | 2 | 0.693 |
MRCKA |
0.797 | 0.157 | -3 | 0.768 |
WNK4 |
0.797 | -0.075 | -2 | 0.876 |
HIPK3 |
0.797 | 0.035 | 1 | 0.677 |
MEKK3 |
0.797 | -0.165 | 1 | 0.768 |
HRI |
0.797 | -0.153 | -2 | 0.889 |
PLK4 |
0.797 | -0.136 | 2 | 0.481 |
SSTK |
0.797 | 0.035 | 4 | 0.835 |
CDK10 |
0.796 | 0.062 | 1 | 0.582 |
DAPK1 |
0.796 | 0.106 | -3 | 0.781 |
ZAK |
0.796 | -0.150 | 1 | 0.749 |
DCAMKL2 |
0.796 | -0.018 | -3 | 0.813 |
AKT3 |
0.796 | 0.122 | -3 | 0.646 |
PINK1 |
0.795 | -0.165 | 1 | 0.781 |
PKCT |
0.795 | -0.014 | 2 | 0.582 |
CDK17 |
0.795 | -0.009 | 1 | 0.511 |
GAK |
0.795 | 0.011 | 1 | 0.780 |
ERK2 |
0.794 | -0.033 | 1 | 0.629 |
MEKK1 |
0.794 | -0.180 | 1 | 0.771 |
TLK1 |
0.794 | -0.106 | -2 | 0.868 |
PHKG2 |
0.794 | -0.015 | -3 | 0.791 |
CDK2 |
0.794 | -0.057 | 1 | 0.663 |
PAK4 |
0.794 | 0.024 | -2 | 0.667 |
ERK1 |
0.794 | -0.022 | 1 | 0.587 |
ROCK2 |
0.793 | 0.151 | -3 | 0.790 |
P38G |
0.793 | -0.002 | 1 | 0.509 |
NEK5 |
0.793 | -0.152 | 1 | 0.779 |
TAO2 |
0.793 | -0.035 | 2 | 0.719 |
CDK12 |
0.793 | -0.034 | 1 | 0.586 |
CK1E |
0.793 | -0.056 | -3 | 0.444 |
GCK |
0.793 | -0.004 | 1 | 0.764 |
GSK3A |
0.793 | 0.023 | 4 | 0.456 |
CDK14 |
0.792 | 0.005 | 1 | 0.597 |
MEKK2 |
0.792 | -0.177 | 2 | 0.667 |
CDK16 |
0.792 | 0.027 | 1 | 0.528 |
LKB1 |
0.792 | -0.045 | -3 | 0.814 |
CRIK |
0.792 | 0.252 | -3 | 0.714 |
IRAK4 |
0.791 | -0.110 | 1 | 0.751 |
GSK3B |
0.791 | -0.014 | 4 | 0.445 |
CDK3 |
0.790 | 0.005 | 1 | 0.531 |
TTBK1 |
0.789 | -0.125 | 2 | 0.505 |
PKCE |
0.789 | 0.014 | 2 | 0.574 |
LOK |
0.789 | 0.013 | -2 | 0.827 |
CAMKK1 |
0.789 | -0.135 | -2 | 0.793 |
PKCI |
0.788 | -0.038 | 2 | 0.593 |
HPK1 |
0.788 | -0.006 | 1 | 0.742 |
CK1D |
0.788 | -0.045 | -3 | 0.396 |
TNIK |
0.788 | -0.014 | 3 | 0.789 |
TAK1 |
0.787 | -0.039 | 1 | 0.815 |
CAMKK2 |
0.786 | -0.104 | -2 | 0.784 |
GRK3 |
0.786 | -0.059 | -2 | 0.706 |
MPSK1 |
0.786 | -0.054 | 1 | 0.736 |
CHK2 |
0.786 | 0.040 | -3 | 0.653 |
IRAK1 |
0.786 | -0.192 | -1 | 0.765 |
NEK11 |
0.785 | -0.193 | 1 | 0.750 |
NEK8 |
0.785 | -0.193 | 2 | 0.666 |
DMPK1 |
0.785 | 0.149 | -3 | 0.764 |
ERK7 |
0.785 | -0.028 | 2 | 0.433 |
HGK |
0.785 | -0.068 | 3 | 0.791 |
MINK |
0.785 | -0.063 | 1 | 0.756 |
PDK1 |
0.783 | -0.115 | 1 | 0.757 |
MST2 |
0.783 | -0.122 | 1 | 0.780 |
CAMK1A |
0.783 | 0.049 | -3 | 0.677 |
PLK2 |
0.783 | -0.031 | -3 | 0.727 |
SBK |
0.783 | 0.074 | -3 | 0.601 |
ROCK1 |
0.783 | 0.138 | -3 | 0.763 |
EEF2K |
0.782 | -0.044 | 3 | 0.762 |
KHS2 |
0.782 | 0.016 | 1 | 0.748 |
MOK |
0.782 | 0.097 | 1 | 0.679 |
CK1A2 |
0.782 | -0.065 | -3 | 0.396 |
SLK |
0.781 | -0.054 | -2 | 0.782 |
P38D |
0.781 | -0.004 | 1 | 0.524 |
NEK4 |
0.781 | -0.156 | 1 | 0.745 |
PKN1 |
0.780 | -0.012 | -3 | 0.728 |
MEKK6 |
0.780 | -0.118 | 1 | 0.769 |
LRRK2 |
0.780 | -0.123 | 2 | 0.708 |
CK1G1 |
0.780 | -0.112 | -3 | 0.455 |
KHS1 |
0.779 | -0.027 | 1 | 0.742 |
JNK1 |
0.779 | -0.017 | 1 | 0.569 |
MAK |
0.778 | 0.060 | -2 | 0.699 |
PBK |
0.778 | -0.000 | 1 | 0.705 |
STK33 |
0.778 | -0.130 | 2 | 0.510 |
NEK1 |
0.778 | -0.124 | 1 | 0.754 |
BUB1 |
0.777 | 0.037 | -5 | 0.716 |
CDK4 |
0.777 | 0.005 | 1 | 0.570 |
MST1 |
0.776 | -0.124 | 1 | 0.755 |
YSK1 |
0.776 | -0.068 | 2 | 0.679 |
MAP3K15 |
0.775 | -0.174 | 1 | 0.734 |
PKG1 |
0.775 | 0.035 | -2 | 0.628 |
CDK6 |
0.774 | -0.021 | 1 | 0.580 |
VRK1 |
0.773 | -0.181 | 2 | 0.678 |
PDHK3_TYR |
0.773 | 0.117 | 4 | 0.887 |
ALPHAK3 |
0.771 | 0.101 | -1 | 0.733 |
MEK2 |
0.770 | -0.206 | 2 | 0.672 |
NEK3 |
0.768 | -0.116 | 1 | 0.726 |
OSR1 |
0.768 | -0.074 | 2 | 0.686 |
TTK |
0.767 | -0.025 | -2 | 0.871 |
PDHK4_TYR |
0.767 | 0.065 | 2 | 0.782 |
TESK1_TYR |
0.767 | 0.035 | 3 | 0.833 |
RIPK2 |
0.766 | -0.254 | 1 | 0.715 |
MAP2K4_TYR |
0.765 | 0.003 | -1 | 0.835 |
MAP2K6_TYR |
0.764 | 0.007 | -1 | 0.830 |
MAP2K7_TYR |
0.763 | -0.096 | 2 | 0.740 |
EPHA6 |
0.762 | 0.136 | -1 | 0.837 |
BMPR2_TYR |
0.762 | -0.007 | -1 | 0.825 |
HASPIN |
0.762 | -0.035 | -1 | 0.667 |
LIMK2_TYR |
0.761 | 0.043 | -3 | 0.867 |
PINK1_TYR |
0.760 | -0.066 | 1 | 0.812 |
PDHK1_TYR |
0.760 | -0.031 | -1 | 0.842 |
YANK3 |
0.760 | -0.061 | 2 | 0.366 |
MYO3B |
0.760 | -0.087 | 2 | 0.683 |
TAO1 |
0.759 | -0.087 | 1 | 0.702 |
BIKE |
0.758 | -0.030 | 1 | 0.640 |
PKMYT1_TYR |
0.758 | -0.095 | 3 | 0.799 |
EPHB4 |
0.758 | 0.090 | -1 | 0.838 |
EPHA4 |
0.757 | 0.121 | 2 | 0.710 |
MYO3A |
0.757 | -0.110 | 1 | 0.739 |
TXK |
0.756 | 0.124 | 1 | 0.837 |
RET |
0.754 | -0.063 | 1 | 0.767 |
SRMS |
0.753 | 0.100 | 1 | 0.864 |
ASK1 |
0.752 | -0.202 | 1 | 0.726 |
DDR1 |
0.752 | -0.049 | 4 | 0.815 |
FER |
0.751 | 0.025 | 1 | 0.874 |
LIMK1_TYR |
0.751 | -0.125 | 2 | 0.717 |
TYRO3 |
0.751 | -0.046 | 3 | 0.728 |
ITK |
0.751 | 0.048 | -1 | 0.820 |
ABL2 |
0.750 | 0.011 | -1 | 0.808 |
MST1R |
0.749 | -0.126 | 3 | 0.745 |
EPHB3 |
0.749 | 0.078 | -1 | 0.836 |
EPHB1 |
0.749 | 0.043 | 1 | 0.858 |
YES1 |
0.749 | -0.001 | -1 | 0.820 |
EPHB2 |
0.748 | 0.087 | -1 | 0.826 |
TYK2 |
0.747 | -0.193 | 1 | 0.771 |
TNK2 |
0.747 | -0.012 | 3 | 0.695 |
STLK3 |
0.747 | -0.176 | 1 | 0.724 |
TEC |
0.746 | 0.065 | -1 | 0.783 |
INSRR |
0.746 | -0.050 | 3 | 0.688 |
CK1A |
0.746 | -0.090 | -3 | 0.311 |
LCK |
0.746 | 0.049 | -1 | 0.823 |
BLK |
0.745 | 0.075 | -1 | 0.822 |
ROS1 |
0.745 | -0.129 | 3 | 0.694 |
EPHA7 |
0.745 | 0.076 | 2 | 0.695 |
HCK |
0.744 | -0.019 | -1 | 0.827 |
ABL1 |
0.744 | -0.026 | -1 | 0.801 |
FGFR2 |
0.744 | -0.082 | 3 | 0.747 |
BMX |
0.744 | 0.033 | -1 | 0.758 |
CSF1R |
0.743 | -0.146 | 3 | 0.729 |
NEK10_TYR |
0.743 | -0.061 | 1 | 0.662 |
MERTK |
0.743 | 0.012 | 3 | 0.717 |
FGR |
0.742 | -0.113 | 1 | 0.803 |
AXL |
0.742 | -0.033 | 3 | 0.719 |
JAK3 |
0.742 | -0.141 | 1 | 0.759 |
TEK |
0.742 | -0.025 | 3 | 0.670 |
JAK2 |
0.741 | -0.224 | 1 | 0.767 |
EPHA5 |
0.741 | 0.092 | 2 | 0.695 |
AAK1 |
0.739 | -0.012 | 1 | 0.532 |
BTK |
0.739 | -0.043 | -1 | 0.812 |
PDGFRB |
0.739 | -0.151 | 3 | 0.734 |
EPHA3 |
0.738 | -0.032 | 2 | 0.669 |
LTK |
0.737 | -0.041 | 3 | 0.679 |
FLT3 |
0.737 | -0.121 | 3 | 0.720 |
EPHA1 |
0.737 | 0.017 | 3 | 0.701 |
KIT |
0.737 | -0.153 | 3 | 0.736 |
PTK2B |
0.736 | 0.018 | -1 | 0.797 |
KDR |
0.736 | -0.124 | 3 | 0.692 |
MET |
0.735 | -0.099 | 3 | 0.724 |
FYN |
0.735 | 0.014 | -1 | 0.788 |
FGFR1 |
0.734 | -0.146 | 3 | 0.709 |
ALK |
0.734 | -0.089 | 3 | 0.651 |
DDR2 |
0.734 | 0.007 | 3 | 0.680 |
TNK1 |
0.734 | -0.130 | 3 | 0.711 |
PTK6 |
0.733 | -0.119 | -1 | 0.745 |
TNNI3K_TYR |
0.732 | -0.111 | 1 | 0.781 |
FRK |
0.732 | -0.032 | -1 | 0.852 |
FGFR3 |
0.731 | -0.122 | 3 | 0.719 |
WEE1_TYR |
0.731 | -0.113 | -1 | 0.772 |
EPHA8 |
0.731 | -0.009 | -1 | 0.806 |
CK1G3 |
0.731 | -0.086 | -3 | 0.270 |
LYN |
0.730 | -0.042 | 3 | 0.648 |
YANK2 |
0.730 | -0.081 | 2 | 0.384 |
FLT1 |
0.730 | -0.145 | -1 | 0.786 |
JAK1 |
0.729 | -0.170 | 1 | 0.713 |
NTRK1 |
0.729 | -0.179 | -1 | 0.799 |
ERBB2 |
0.729 | -0.155 | 1 | 0.732 |
PDGFRA |
0.728 | -0.238 | 3 | 0.724 |
SYK |
0.726 | 0.048 | -1 | 0.734 |
PTK2 |
0.726 | -0.002 | -1 | 0.729 |
NTRK2 |
0.724 | -0.202 | 3 | 0.686 |
INSR |
0.724 | -0.164 | 3 | 0.662 |
MATK |
0.724 | -0.122 | -1 | 0.728 |
FLT4 |
0.724 | -0.199 | 3 | 0.691 |
EPHA2 |
0.723 | -0.007 | -1 | 0.774 |
EGFR |
0.722 | -0.092 | 1 | 0.647 |
NTRK3 |
0.722 | -0.159 | -1 | 0.758 |
SRC |
0.721 | -0.089 | -1 | 0.783 |
FGFR4 |
0.718 | -0.122 | -1 | 0.747 |
CSK |
0.718 | -0.168 | 2 | 0.691 |
CK1G2 |
0.712 | -0.082 | -3 | 0.368 |
IGF1R |
0.711 | -0.153 | 3 | 0.606 |
ERBB4 |
0.708 | -0.082 | 1 | 0.671 |
MUSK |
0.706 | -0.182 | 1 | 0.630 |
FES |
0.699 | -0.122 | -1 | 0.723 |
ZAP70 |
0.697 | -0.068 | -1 | 0.670 |