Motif 668 (n=225)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2193 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NI28 | ARHGAP42 | S587 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NKT7 | RGPD3 | S1545 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H7BY64 | ZNF511-PRAP1 | S151 | ochoa | ZNF511-PRAP1 readthrough | None |
| H7C1D1 | None | S33 | ochoa | DUF4657 domain-containing protein | None |
| O00151 | PDLIM1 | S213 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00186 | STXBP3 | S512 | ochoa | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
| O00213 | APBB1 | S205 | ochoa | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00443 | PIK3C2A | S329 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O14920 | IKBKB | S258 | psp | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15061 | SYNM | S1090 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15226 | NKRF | S91 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15541 | RNF113A | S268 | ochoa | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| O43166 | SIPA1L1 | S288 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43379 | WDR62 | S1270 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43768 | ENSA | S43 | ochoa | Alpha-endosulfine (ARPP-19e) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| O60784 | TOM1 | S405 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O60884 | DNAJA2 | S378 | ochoa | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| O75348 | ATP6V1G1 | S70 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75410 | TACC1 | S228 | psp | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75937 | DNAJC8 | S35 | ochoa | DnaJ homolog subfamily C member 8 (Splicing protein spf31) | Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. |
| O95149 | SNUPN | S329 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95235 | KIF20A | S668 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95436 | SLC34A2 | S671 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| O95613 | PCNT | S2477 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P01275 | GCG | S152 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P02730 | SLC4A1 | S50 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P03372 | ESR1 | S341 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04004 | VTN | S312 | ochoa|psp | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P07195 | LDHB | S303 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P08172 | CHRM2 | S290 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08183 | ABCB1 | S654 | ochoa | ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) | Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}. |
| P08708 | RPS17 | S115 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P09960 | LTA4H | S81 | ochoa | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
| P0DJD0 | RGPD1 | S1529 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1537 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11142 | HSPA8 | S541 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P13674 | P4HA1 | S366 | ochoa | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
| P14314 | PRKCSH | S230 | ochoa | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P15822 | HIVEP1 | S1143 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16615 | ATP2A2 | S170 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P18583 | SON | S353 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19801 | AOC1 | S275 | ochoa | Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) (KDAO) | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses (PubMed:12072962). Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism (PubMed:12072962). It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes (PubMed:12072962, PubMed:239684). {ECO:0000269|PubMed:12072962, ECO:0000269|PubMed:19764817, ECO:0000269|PubMed:239684, ECO:0000269|PubMed:8144586}. |
| P19838 | NFKB1 | S80 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P20810 | CAST | S411 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S1921 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22314 | UBA1 | S276 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23497 | SP100 | S350 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P29558 | RBMS1 | S213 | ochoa | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. |
| P30203 | CD6 | S505 | psp | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}. |
| P31270 | HOXA11 | S220 | ochoa | Homeobox protein Hox-A11 (Homeobox protein Hox-1I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P35221 | CTNNA1 | S655 | ochoa|psp | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35269 | GTF2F1 | S391 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35568 | IRS1 | S24 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S1070 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35579 | MYH9 | S1243 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P40425 | PBX2 | S330 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P41235 | HNF4A | S303 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P45378 | TNNT3 | S160 | ochoa | Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P45974 | USP5 | S787 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46013 | MKI67 | S3042 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48163 | ME1 | S336 | psp | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| P48444 | ARCN1 | S252 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48634 | PRRC2A | S363 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49321 | NASP | S244 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49792 | RANBP2 | S2520 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P54274 | TERF1 | S114 | psp | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}. |
| P54920 | NAPA | S157 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P61964 | WDR5 | S22 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| P62280 | RPS11 | S67 | ochoa | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62993 | GRB2 | S90 | ochoa | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis (PubMed:35831301, PubMed:37626338, PubMed:38182563). Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 (PubMed:9489702). In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation (PubMed:12171928, PubMed:25870599). Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232, PubMed:29523808). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 (PubMed:35831301, PubMed:38182563). Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 (PubMed:37328606). Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks (PubMed:38459011). Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process (PubMed:34348893). {ECO:0000269|PubMed:11726515, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:25413232, ECO:0000269|PubMed:25870599, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:34348893, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:36864087, ECO:0000269|PubMed:37328606, ECO:0000269|PubMed:37626338, ECO:0000269|PubMed:38182563, ECO:0000269|PubMed:38459011, ECO:0000269|PubMed:9489702}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment (PubMed:36171279). {ECO:0000269|PubMed:36171279, ECO:0000269|PubMed:8178156}. |
| P78312 | FAM193A | S858 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78559 | MAP1A | S771 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S878 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98175 | RBM10 | S207 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00536 | CDK16 | S64 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00653 | NFKB2 | S277 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01082 | SPTBN1 | S903 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01082 | SPTBN1 | S2122 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02487 | DSC2 | S796 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q03468 | ERCC6 | S1379 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q05209 | PTPN12 | S449 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08378 | GOLGA3 | S389 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q09666 | AHNAK | S20 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12815 | TROAP | S417 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12888 | TP53BP1 | S831 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S898 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12979 | ABR | S632 | ochoa | Active breakpoint cluster region-related protein | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}. |
| Q13129 | RLF | S1228 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13263 | TRIM28 | S816 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13370 | PDE3B | S554 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13428 | TCOF1 | S369 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13501 | SQSTM1 | S407 | psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13561 | DCTN2 | S127 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13905 | RAPGEF1 | S251 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14669 | TRIP12 | S1113 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14674 | ESPL1 | S1501 | ochoa|psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14789 | GOLGB1 | S1792 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15043 | SLC39A14 | S311 | ochoa | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}. |
| Q15059 | BRD3 | S359 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15276 | RABEP1 | S491 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15424 | SAFB | S794 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15772 | SPEG | S2343 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15911 | ZFHX3 | S1179 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16143 | SNCB | S64 | ochoa | Beta-synuclein | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Q16637 | SMN1 | S180 | psp | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q27J81 | INF2 | S23 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2KHR3 | QSER1 | S607 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q3L8U1 | CHD9 | S550 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q3L8U1 | CHD9 | S2009 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q4G0J3 | LARP7 | S249 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q5JTH9 | RRP12 | S91 | ochoa | RRP12-like protein | None |
| Q5JTV8 | TOR1AIP1 | S179 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5QJE6 | DNTTIP2 | S37 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S1133 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T200 | ZC3H13 | S1455 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TAP6 | UTP14C | S536 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
| Q5VT06 | CEP350 | S2174 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VWN6 | TASOR2 | S601 | ochoa | Protein TASOR 2 | None |
| Q6BDS2 | BLTP3A | S957 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6P9B6 | MEAK7 | S425 | ochoa | MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) | Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q6PGN9 | PSRC1 | S98 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6PJT7 | ZC3H14 | S475 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6ZRS2 | SRCAP | S2370 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZT07 | TBC1D9 | S1192 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZU35 | CRACD | S132 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUJ8 | PIK3AP1 | S642 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q6ZVM7 | TOM1L2 | S423 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q71F23 | CENPU | S190 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7LBC6 | KDM3B | S278 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z3J3 | RGPD4 | S1545 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z417 | NUFIP2 | S586 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z6I6 | ARHGAP30 | S384 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86TC9 | MYPN | T250 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86U44 | METTL3 | S358 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86VS8 | HOOK3 | S230 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86XD5 | FAM131B | S105 | ochoa | Protein FAM131B | None |
| Q86XP3 | DDX42 | S45 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IUD2 | ERC1 | S374 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IYF3 | TEX11 | S190 | ochoa | Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) | Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}. |
| Q8N4N8 | KIF2B | S204 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N8A6 | DDX51 | S103 | ochoa | ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) | ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. {ECO:0000250}. |
| Q8N960 | CEP120 | S345 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
| Q8N9B5 | JMY | S856 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NDX1 | PSD4 | S763 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEV8 | EXPH5 | S320 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NF91 | SYNE1 | S1361 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S2124 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFQ8 | TOR1AIP2 | S93 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NHV4 | NEDD1 | S493 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TBC5 | ZSCAN18 | S345 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TD55 | PLEKHO2 | S433 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TF72 | SHROOM3 | S921 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WU90 | ZC3H15 | S326 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q8WUM9 | SLC20A1 | S455 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WWI1 | LMO7 | S1187 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92793 | CREBBP | S1072 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969R5 | L3MBTL2 | S335 | psp | Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}. |
| Q96CC6 | RHBDF1 | S191 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96IY1 | NSL1 | S24 | ochoa | Kinetochore-associated protein NSL1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}. |
| Q96JY6 | PDLIM2 | S239 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96PV7 | FAM193B | S709 | ochoa | Protein FAM193B | None |
| Q9BVJ6 | UTP14A | S538 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW71 | HIRIP3 | S500 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXF6 | RAB11FIP5 | S174 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BZL6 | PRKD2 | S374 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C073 | FAM117A | S305 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0C2 | TNKS1BP1 | S1261 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C9 | UBE2O | S904 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9GZP1 | NRSN2 | S178 | ochoa | Neurensin-2 | May play a role in maintenance and/or transport of vesicles. |
| Q9H115 | NAPB | S157 | ochoa | Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}. |
| Q9H2P0 | ADNP | S805 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4A6 | GOLPH3 | S35 | ochoa | Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) | Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}. |
| Q9H4L7 | SMARCAD1 | S79 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H788 | SH2D4A | S118 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9H992 | MARCHF7 | S389 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9NP98 | MYOZ1 | S39 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NR33 | POLE4 | S32 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
| Q9NRF2 | SH2B1 | S88 | ochoa | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
| Q9NVF7 | FBXO28 | S330 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9NVN8 | GNL3L | S87 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NWQ8 | PAG1 | S150 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NX63 | CHCHD3 | S179 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NZI8 | IGF2BP1 | S73 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9P0J7 | KCMF1 | S212 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9UDT6 | CLIP2 | S170 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UEY8 | ADD3 | S414 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9ULD9 | ZNF608 | S1453 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9UNY4 | TTF2 | S364 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPT8 | ZC3H4 | S807 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQC2 | GAB2 | S425 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2L6 | FRMD4B | S915 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y4B5 | MTCL1 | S618 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F1 | FARP1 | S899 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4F9 | RIPOR2 | S593 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y4G8 | RAPGEF2 | S498 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y5P3 | RAI2 | S333 | ochoa | Retinoic acid-induced protein 2 | None |
| Q9Y6J0 | CABIN1 | S447 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P07814 | EPRS1 | S335 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08174 | CD55 | S68 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| P27824 | CANX | S362 | Sugiyama | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Q02952 | AKAP12 | S1367 | Sugiyama | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q15648 | MED1 | S935 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q9Y696 | CLIC4 | S31 | Sugiyama | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
| O15067 | PFAS | S227 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O75821 | EIF3G | T210 | Sugiyama | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q8N3D4 | EHBP1L1 | S1360 | Sugiyama | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| P02786 | TFRC | S361 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P27635 | RPL10 | S168 | SIGNOR|EPSD | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| Q9H2G2 | SLK | S1210 | Sugiyama | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| P54105 | CLNS1A | S42 | Sugiyama | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| Q9Y5K3 | PCYT1B | S174 | Sugiyama | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q9H6Z4 | RANBP3 | S57 | SIGNOR | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| P36894 | BMPR1A | S215 | Sugiyama | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}. |
| O14545 | TRAFD1 | S191 | Sugiyama | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| Q15569 | TESK1 | S79 | Sugiyama | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| P61586 | RHOA | S160 | Sugiyama | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed:23871831). Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:31570889, PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:12900402, PubMed:16236794). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:19403695, PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis. {ECO:0000250|UniProtKB:P61589, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:31570889, ECO:0000269|PubMed:31888991, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}.; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. |
| O15372 | EIF3H | S302 | Sugiyama | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P50502 | ST13 | S218 | Sugiyama | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| Q8NFI4 | ST13P5 | S218 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
| Q86TU7 | SETD3 | S505 | Sugiyama | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q7LBC6 | KDM3B | S810 | Sugiyama | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| P30622 | CLIP1 | S383 | Sugiyama | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| Q9UHD2 | TBK1 | S243 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| P49736 | MCM2 | S187 | Sugiyama | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.000281 | 3.551 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.000485 | 3.314 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.000596 | 3.225 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000738 | 3.132 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.001712 | 2.766 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.001500 | 2.824 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.001632 | 2.787 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.001277 | 2.894 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.002254 | 2.647 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.002740 | 2.562 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.003326 | 2.478 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.003326 | 2.478 |
| R-HSA-5660489 | MTF1 activates gene expression | 0.004001 | 2.398 |
| R-HSA-186712 | Regulation of beta-cell development | 0.004068 | 2.391 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.005363 | 2.271 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.005391 | 2.268 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.005391 | 2.268 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.005764 | 2.239 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.004736 | 2.325 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.006425 | 2.192 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.006971 | 2.157 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.006832 | 2.165 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.007602 | 2.119 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.007745 | 2.111 |
| R-HSA-9645135 | STAT5 Activation | 0.008734 | 2.059 |
| R-HSA-112412 | SOS-mediated signalling | 0.010675 | 1.972 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.017505 | 1.757 |
| R-HSA-198203 | PI3K/AKT activation | 0.017505 | 1.757 |
| R-HSA-72649 | Translation initiation complex formation | 0.016124 | 1.793 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.017883 | 1.748 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.015899 | 1.799 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.015899 | 1.799 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.011353 | 1.945 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.018710 | 1.728 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.011575 | 1.936 |
| R-HSA-74749 | Signal attenuation | 0.017505 | 1.757 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.019096 | 1.719 |
| R-HSA-112399 | IRS-mediated signalling | 0.018805 | 1.726 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.011353 | 1.945 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.008734 | 2.059 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.016202 | 1.790 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.016202 | 1.790 |
| R-HSA-176974 | Unwinding of DNA | 0.015066 | 1.822 |
| R-HSA-109704 | PI3K Cascade | 0.012943 | 1.888 |
| R-HSA-9683686 | Maturation of spike protein | 0.017505 | 1.757 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.008420 | 2.075 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.010195 | 1.992 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.019756 | 1.704 |
| R-HSA-68877 | Mitotic Prometaphase | 0.017971 | 1.745 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.017174 | 1.765 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.014845 | 1.828 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.012787 | 1.893 |
| R-HSA-448706 | Interleukin-1 processing | 0.015066 | 1.822 |
| R-HSA-2586552 | Signaling by Leptin | 0.017505 | 1.757 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.018710 | 1.728 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.018710 | 1.728 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.010932 | 1.961 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.010932 | 1.961 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.020737 | 1.683 |
| R-HSA-191859 | snRNP Assembly | 0.020737 | 1.683 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.035218 | 1.453 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.031925 | 1.496 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.027801 | 1.556 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.027801 | 1.556 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.025955 | 1.586 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.026084 | 1.584 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.022786 | 1.642 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.026084 | 1.584 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.029713 | 1.527 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.028220 | 1.549 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.027243 | 1.565 |
| R-HSA-9842663 | Signaling by LTK | 0.025732 | 1.590 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.024197 | 1.616 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.025732 | 1.590 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.025732 | 1.590 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.028743 | 1.541 |
| R-HSA-8953854 | Metabolism of RNA | 0.024898 | 1.604 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.028433 | 1.546 |
| R-HSA-199991 | Membrane Trafficking | 0.031175 | 1.506 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.025732 | 1.590 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.035218 | 1.453 |
| R-HSA-168255 | Influenza Infection | 0.035096 | 1.455 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.033080 | 1.480 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.034948 | 1.457 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.026149 | 1.583 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 0.045156 | 1.345 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 0.045156 | 1.345 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.045156 | 1.345 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.045156 | 1.345 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.045156 | 1.345 |
| R-HSA-209563 | Axonal growth stimulation | 0.074125 | 1.130 |
| R-HSA-8865999 | MET activates PTPN11 | 0.074125 | 1.130 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.074125 | 1.130 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.074125 | 1.130 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.088280 | 1.054 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.102219 | 0.990 |
| R-HSA-74713 | IRS activation | 0.102219 | 0.990 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.115946 | 0.936 |
| R-HSA-109703 | PKB-mediated events | 0.115946 | 0.936 |
| R-HSA-165160 | PDE3B signalling | 0.115946 | 0.936 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.129464 | 0.888 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.142776 | 0.845 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.155886 | 0.807 |
| R-HSA-8875656 | MET receptor recycling | 0.155886 | 0.807 |
| R-HSA-180292 | GAB1 signalosome | 0.049601 | 1.305 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.168795 | 0.773 |
| R-HSA-9613354 | Lipophagy | 0.168795 | 0.773 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.206356 | 0.685 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.218497 | 0.661 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.230453 | 0.637 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.102105 | 0.991 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.253820 | 0.595 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.265238 | 0.576 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.276481 | 0.558 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.287554 | 0.541 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.097868 | 1.009 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.097868 | 1.009 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.107286 | 0.969 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.070180 | 1.154 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.180354 | 0.744 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.072196 | 1.141 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.080553 | 1.094 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.130541 | 0.884 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.202523 | 0.694 |
| R-HSA-380287 | Centrosome maturation | 0.137488 | 0.862 |
| R-HSA-192823 | Viral mRNA Translation | 0.101006 | 0.996 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.148137 | 0.829 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.113307 | 0.946 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.241938 | 0.616 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.258953 | 0.587 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.189235 | 0.723 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.270307 | 0.568 |
| R-HSA-1989781 | PPARA activates gene expression | 0.130774 | 0.883 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.113408 | 0.945 |
| R-HSA-72172 | mRNA Splicing | 0.134413 | 0.872 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.230453 | 0.637 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.135309 | 0.869 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.197002 | 0.706 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.158598 | 0.800 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.074020 | 1.131 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.093515 | 1.029 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.211563 | 0.675 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.074330 | 1.129 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.230453 | 0.637 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.126235 | 0.899 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.142776 | 0.845 |
| R-HSA-156902 | Peptide chain elongation | 0.064309 | 1.192 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.126235 | 0.899 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.217971 | 0.662 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.128533 | 0.891 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.253820 | 0.595 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.276481 | 0.558 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.042177 | 1.375 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.218497 | 0.661 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.054120 | 1.267 |
| R-HSA-8939211 | ESR-mediated signaling | 0.207039 | 0.684 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.230623 | 0.637 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.147918 | 0.830 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.102219 | 0.990 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.155886 | 0.807 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.206356 | 0.685 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.106977 | 0.971 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.180354 | 0.744 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.241938 | 0.616 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.049601 | 1.305 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.168795 | 0.773 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.092555 | 1.034 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.253820 | 0.595 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.253820 | 0.595 |
| R-HSA-3371568 | Attenuation phase | 0.163991 | 0.785 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.082714 | 1.082 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.048308 | 1.316 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.084903 | 1.071 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.053477 | 1.272 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.057456 | 1.241 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.206356 | 0.685 |
| R-HSA-177929 | Signaling by EGFR | 0.077315 | 1.112 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.162341 | 0.790 |
| R-HSA-182971 | EGFR downregulation | 0.111911 | 0.951 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.265238 | 0.576 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.105095 | 0.978 |
| R-HSA-9663891 | Selective autophagy | 0.064309 | 1.192 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.074125 | 1.130 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 0.074125 | 1.130 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.115946 | 0.936 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.129464 | 0.888 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.142776 | 0.845 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.155886 | 0.807 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.168795 | 0.773 |
| R-HSA-68952 | DNA replication initiation | 0.181508 | 0.741 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.194028 | 0.712 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.078769 | 1.104 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.206356 | 0.685 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.206356 | 0.685 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.092555 | 1.034 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.097296 | 1.012 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.253820 | 0.595 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.253820 | 0.595 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.132199 | 0.879 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.276481 | 0.558 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.230623 | 0.637 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.064277 | 1.192 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.287326 | 0.542 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.253206 | 0.597 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.282137 | 0.550 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.272134 | 0.565 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.286297 | 0.543 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.180354 | 0.744 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.102712 | 0.988 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.218497 | 0.661 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.276481 | 0.558 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.074242 | 1.129 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.096269 | 1.017 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.249107 | 0.604 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.155886 | 0.807 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.132199 | 0.879 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.287554 | 0.541 |
| R-HSA-9711097 | Cellular response to starvation | 0.056564 | 1.247 |
| R-HSA-8875878 | MET promotes cell motility | 0.153239 | 0.815 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.113754 | 0.944 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.102219 | 0.990 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.142776 | 0.845 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.181508 | 0.741 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.206356 | 0.685 |
| R-HSA-8851805 | MET activates RAS signaling | 0.218497 | 0.661 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.218497 | 0.661 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.276481 | 0.558 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.079527 | 1.099 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.287554 | 0.541 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.287554 | 0.541 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.083288 | 1.079 |
| R-HSA-3371556 | Cellular response to heat stress | 0.156699 | 0.805 |
| R-HSA-9612973 | Autophagy | 0.281062 | 0.551 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.049601 | 1.305 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.052928 | 1.276 |
| R-HSA-5205647 | Mitophagy | 0.132199 | 0.879 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.120991 | 0.917 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.106977 | 0.971 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.115946 | 0.936 |
| R-HSA-2161517 | Abacavir transmembrane transport | 0.129464 | 0.888 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.168795 | 0.773 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.181508 | 0.741 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.181508 | 0.741 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.206356 | 0.685 |
| R-HSA-77387 | Insulin receptor recycling | 0.097296 | 1.012 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.242226 | 0.616 |
| R-HSA-9018681 | Biosynthesis of protectins | 0.242226 | 0.616 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.253820 | 0.595 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.132199 | 0.879 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.071833 | 1.144 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.120991 | 0.917 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.170188 | 0.769 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.124647 | 0.904 |
| R-HSA-9843745 | Adipogenesis | 0.192678 | 0.715 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.282137 | 0.550 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.108309 | 0.965 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.102105 | 0.991 |
| R-HSA-72312 | rRNA processing | 0.195217 | 0.709 |
| R-HSA-1632852 | Macroautophagy | 0.227681 | 0.643 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.228780 | 0.641 |
| R-HSA-9664873 | Pexophagy | 0.181508 | 0.741 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.059286 | 1.227 |
| R-HSA-8853659 | RET signaling | 0.142636 | 0.846 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.042177 | 1.375 |
| R-HSA-5260271 | Diseases of Immune System | 0.036869 | 1.433 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.036869 | 1.433 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.218497 | 0.661 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.242226 | 0.616 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.253820 | 0.595 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.253820 | 0.595 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.174871 | 0.757 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.096269 | 1.017 |
| R-HSA-983189 | Kinesins | 0.281656 | 0.550 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.236875 | 0.625 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.088808 | 1.052 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.236875 | 0.625 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.236875 | 0.625 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.078769 | 1.104 |
| R-HSA-917937 | Iron uptake and transport | 0.040527 | 1.392 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.261432 | 0.583 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.286297 | 0.543 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.042950 | 1.367 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.133999 | 0.873 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.275983 | 0.559 |
| R-HSA-9607240 | FLT3 Signaling | 0.169416 | 0.771 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.234215 | 0.630 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.067757 | 1.169 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.102219 | 0.990 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.115946 | 0.936 |
| R-HSA-444821 | Relaxin receptors | 0.115946 | 0.936 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.168795 | 0.773 |
| R-HSA-425381 | Bicarbonate transporters | 0.194028 | 0.712 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.206356 | 0.685 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.218497 | 0.661 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.218497 | 0.661 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.218497 | 0.661 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.265238 | 0.576 |
| R-HSA-9694548 | Maturation of spike protein | 0.169416 | 0.771 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.103414 | 0.985 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.236277 | 0.627 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.254076 | 0.595 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.132199 | 0.879 |
| R-HSA-2262752 | Cellular responses to stress | 0.082223 | 1.085 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.121950 | 0.914 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.219344 | 0.659 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.142391 | 0.847 |
| R-HSA-450294 | MAP kinase activation | 0.287326 | 0.542 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.127050 | 0.896 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.224978 | 0.648 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.065710 | 1.182 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.091115 | 1.040 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.185863 | 0.731 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.102219 | 0.990 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.115946 | 0.936 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.115946 | 0.936 |
| R-HSA-447041 | CHL1 interactions | 0.142776 | 0.845 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.168795 | 0.773 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.194028 | 0.712 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.121950 | 0.914 |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 0.287554 | 0.541 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.040549 | 1.392 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.174871 | 0.757 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.208114 | 0.682 |
| R-HSA-3214847 | HATs acetylate histones | 0.240940 | 0.618 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.059631 | 1.225 |
| R-HSA-73887 | Death Receptor Signaling | 0.051748 | 1.286 |
| R-HSA-186763 | Downstream signal transduction | 0.111911 | 0.951 |
| R-HSA-69239 | Synthesis of DNA | 0.277983 | 0.556 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.056824 | 1.245 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.253820 | 0.595 |
| R-HSA-68886 | M Phase | 0.049496 | 1.305 |
| R-HSA-1640170 | Cell Cycle | 0.060251 | 1.220 |
| R-HSA-162582 | Signal Transduction | 0.228444 | 0.641 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.115946 | 0.936 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.042177 | 1.375 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.206356 | 0.685 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.218497 | 0.661 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.276481 | 0.558 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.287554 | 0.541 |
| R-HSA-1221632 | Meiotic synapsis | 0.241938 | 0.616 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.169416 | 0.771 |
| R-HSA-73884 | Base Excision Repair | 0.197002 | 0.706 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.247606 | 0.606 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.069976 | 1.155 |
| R-HSA-170968 | Frs2-mediated activation | 0.230453 | 0.637 |
| R-HSA-435354 | Zinc transporters | 0.242226 | 0.616 |
| R-HSA-9659379 | Sensory processing of sound | 0.151745 | 0.819 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.162511 | 0.789 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.036869 | 1.433 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.181508 | 0.741 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.180354 | 0.744 |
| R-HSA-73928 | Depyrimidination | 0.180354 | 0.744 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.218497 | 0.661 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.242226 | 0.616 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.242226 | 0.616 |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 0.242226 | 0.616 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.132199 | 0.879 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.147918 | 0.830 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.287554 | 0.541 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.113754 | 0.944 |
| R-HSA-69190 | DNA strand elongation | 0.116903 | 0.932 |
| R-HSA-186797 | Signaling by PDGF | 0.094807 | 1.023 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.067970 | 1.168 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.142776 | 0.845 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.242226 | 0.616 |
| R-HSA-187687 | Signalling to ERKs | 0.137395 | 0.862 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.077315 | 1.112 |
| R-HSA-68882 | Mitotic Anaphase | 0.159264 | 0.798 |
| R-HSA-1266738 | Developmental Biology | 0.205787 | 0.687 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.202523 | 0.694 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.161421 | 0.792 |
| R-HSA-75893 | TNF signaling | 0.258953 | 0.587 |
| R-HSA-9830369 | Kidney development | 0.110502 | 0.957 |
| R-HSA-9831926 | Nephron development | 0.049601 | 1.305 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.100034 | 1.000 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.271865 | 0.566 |
| R-HSA-166520 | Signaling by NTRKs | 0.254076 | 0.595 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.072142 | 1.142 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.168795 | 0.773 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.194028 | 0.712 |
| R-HSA-8876725 | Protein methylation | 0.253820 | 0.595 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.246560 | 0.608 |
| R-HSA-1500931 | Cell-Cell communication | 0.262454 | 0.581 |
| R-HSA-169893 | Prolonged ERK activation events | 0.265238 | 0.576 |
| R-HSA-5683826 | Surfactant metabolism | 0.191395 | 0.718 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.245983 | 0.609 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.242226 | 0.616 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.267506 | 0.573 |
| R-HSA-449147 | Signaling by Interleukins | 0.076610 | 1.116 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.102105 | 0.991 |
| R-HSA-4839726 | Chromatin organization | 0.124331 | 0.905 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.047265 | 1.325 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.151719 | 0.819 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.180401 | 0.744 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.137395 | 0.862 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.202523 | 0.694 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.202523 | 0.694 |
| R-HSA-9754706 | Atorvastatin ADME | 0.265238 | 0.576 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.174871 | 0.757 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.119333 | 0.923 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.218497 | 0.661 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.074330 | 1.129 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.097868 | 1.009 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.274270 | 0.562 |
| R-HSA-8983711 | OAS antiviral response | 0.218497 | 0.661 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.236277 | 0.627 |
| R-HSA-5660526 | Response to metal ions | 0.042177 | 1.375 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.110796 | 0.955 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.152872 | 0.816 |
| R-HSA-9679506 | SARS-CoV Infections | 0.276381 | 0.558 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.102219 | 0.990 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.151745 | 0.819 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.053477 | 1.272 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.145317 | 0.838 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.258595 | 0.587 |
| R-HSA-168268 | Virus Assembly and Release | 0.265238 | 0.576 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.166448 | 0.779 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.100969 | 0.996 |
| R-HSA-9707616 | Heme signaling | 0.094807 | 1.023 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.081469 | 1.089 |
| R-HSA-622312 | Inflammasomes | 0.097296 | 1.012 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.260774 | 0.584 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.159044 | 0.798 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.214790 | 0.668 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.287881 | 0.541 |
| R-HSA-202403 | TCR signaling | 0.290462 | 0.537 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.292992 | 0.533 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.292992 | 0.533 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.298457 | 0.525 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.298457 | 0.525 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.298457 | 0.525 |
| R-HSA-210993 | Tie2 Signaling | 0.298457 | 0.525 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.298457 | 0.525 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.298651 | 0.525 |
| R-HSA-373755 | Semaphorin interactions | 0.298651 | 0.525 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.302981 | 0.519 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.309194 | 0.510 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.309194 | 0.510 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.309194 | 0.510 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.309194 | 0.510 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.309194 | 0.510 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.309194 | 0.510 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.309194 | 0.510 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.309194 | 0.510 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.309194 | 0.510 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.315526 | 0.501 |
| R-HSA-6798695 | Neutrophil degranulation | 0.317796 | 0.498 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.319711 | 0.495 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.319767 | 0.495 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.319767 | 0.495 |
| R-HSA-9629569 | Protein hydroxylation | 0.319767 | 0.495 |
| R-HSA-373753 | Nephrin family interactions | 0.319767 | 0.495 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.321206 | 0.493 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.325028 | 0.488 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.330180 | 0.481 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.330180 | 0.481 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.330180 | 0.481 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.330180 | 0.481 |
| R-HSA-167044 | Signalling to RAS | 0.330180 | 0.481 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.330180 | 0.481 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.330180 | 0.481 |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 0.330180 | 0.481 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.330180 | 0.481 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.336129 | 0.473 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.336451 | 0.473 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.336451 | 0.473 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.338007 | 0.471 |
| R-HSA-448424 | Interleukin-17 signaling | 0.338007 | 0.471 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.338007 | 0.471 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.339597 | 0.469 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.340433 | 0.468 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.340433 | 0.468 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.340433 | 0.468 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.340433 | 0.468 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.340433 | 0.468 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.343580 | 0.464 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.343580 | 0.464 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.348995 | 0.457 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.348995 | 0.457 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.349138 | 0.457 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.350530 | 0.455 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.350530 | 0.455 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.350530 | 0.455 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.350530 | 0.455 |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | 0.350530 | 0.455 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.350530 | 0.455 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.350530 | 0.455 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.350530 | 0.455 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.354681 | 0.450 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.354681 | 0.450 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.354681 | 0.450 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.360207 | 0.443 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.360207 | 0.443 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.360474 | 0.443 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.360474 | 0.443 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.360474 | 0.443 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.360474 | 0.443 |
| R-HSA-3000170 | Syndecan interactions | 0.360474 | 0.443 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.365680 | 0.437 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.365680 | 0.437 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.365680 | 0.437 |
| R-HSA-69206 | G1/S Transition | 0.365680 | 0.437 |
| R-HSA-194138 | Signaling by VEGF | 0.365680 | 0.437 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.365715 | 0.437 |
| R-HSA-8852135 | Protein ubiquitination | 0.365715 | 0.437 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.370265 | 0.431 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.370265 | 0.431 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.370265 | 0.431 |
| R-HSA-429947 | Deadenylation of mRNA | 0.370265 | 0.431 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.370265 | 0.431 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.370265 | 0.431 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.371205 | 0.430 |
| R-HSA-69481 | G2/M Checkpoints | 0.373998 | 0.427 |
| R-HSA-422475 | Axon guidance | 0.374661 | 0.426 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.376677 | 0.424 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.379908 | 0.420 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.379908 | 0.420 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.379908 | 0.420 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.379908 | 0.420 |
| R-HSA-3214842 | HDMs demethylate histones | 0.379908 | 0.420 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.379908 | 0.420 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.382128 | 0.418 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.382128 | 0.418 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.389403 | 0.410 |
| R-HSA-525793 | Myogenesis | 0.389403 | 0.410 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.389403 | 0.410 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.389403 | 0.410 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.389403 | 0.410 |
| R-HSA-2161522 | Abacavir ADME | 0.389403 | 0.410 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.392970 | 0.406 |
| R-HSA-6806834 | Signaling by MET | 0.392970 | 0.406 |
| R-HSA-9833482 | PKR-mediated signaling | 0.392970 | 0.406 |
| R-HSA-168256 | Immune System | 0.395063 | 0.403 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.398753 | 0.399 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.398753 | 0.399 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.398753 | 0.399 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.398753 | 0.399 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.398753 | 0.399 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.398753 | 0.399 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.398753 | 0.399 |
| R-HSA-8949613 | Cristae formation | 0.398753 | 0.399 |
| R-HSA-201451 | Signaling by BMP | 0.398753 | 0.399 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.398753 | 0.399 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.398753 | 0.399 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.398753 | 0.399 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.398753 | 0.399 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.398753 | 0.399 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.398753 | 0.399 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.398753 | 0.399 |
| R-HSA-9909396 | Circadian clock | 0.398814 | 0.399 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.405420 | 0.392 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.407961 | 0.389 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.407961 | 0.389 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.407961 | 0.389 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.407961 | 0.389 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.407961 | 0.389 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.407961 | 0.389 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.407961 | 0.389 |
| R-HSA-9757110 | Prednisone ADME | 0.407961 | 0.389 |
| R-HSA-72086 | mRNA Capping | 0.417028 | 0.380 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.417028 | 0.380 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.417028 | 0.380 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.417028 | 0.380 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.417028 | 0.380 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.417028 | 0.380 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.417028 | 0.380 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.417028 | 0.380 |
| R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 0.417028 | 0.380 |
| R-HSA-1500620 | Meiosis | 0.419687 | 0.377 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.420422 | 0.376 |
| R-HSA-9609690 | HCMV Early Events | 0.422591 | 0.374 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.423357 | 0.373 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.425957 | 0.371 |
| R-HSA-2424491 | DAP12 signaling | 0.425957 | 0.371 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.425957 | 0.371 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.425957 | 0.371 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.425957 | 0.371 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.425957 | 0.371 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.429745 | 0.367 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.434750 | 0.362 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.434750 | 0.362 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.434750 | 0.362 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.434750 | 0.362 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.434750 | 0.362 |
| R-HSA-70268 | Pyruvate metabolism | 0.435429 | 0.361 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.435503 | 0.361 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.435503 | 0.361 |
| R-HSA-9664407 | Parasite infection | 0.435503 | 0.361 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.436243 | 0.360 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.439530 | 0.357 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.443409 | 0.353 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.443409 | 0.353 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.446423 | 0.350 |
| R-HSA-202424 | Downstream TCR signaling | 0.450939 | 0.346 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.450939 | 0.346 |
| R-HSA-9675108 | Nervous system development | 0.451021 | 0.346 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.451935 | 0.345 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.451935 | 0.345 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.451935 | 0.345 |
| R-HSA-9930044 | Nuclear RNA decay | 0.451935 | 0.345 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.451935 | 0.345 |
| R-HSA-354192 | Integrin signaling | 0.451935 | 0.345 |
| R-HSA-9733709 | Cardiogenesis | 0.451935 | 0.345 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.451935 | 0.345 |
| R-HSA-390522 | Striated Muscle Contraction | 0.460332 | 0.337 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.460332 | 0.337 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.460332 | 0.337 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.460332 | 0.337 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.460332 | 0.337 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.460332 | 0.337 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.463459 | 0.334 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.466206 | 0.331 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.466206 | 0.331 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.468600 | 0.329 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.468600 | 0.329 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.468600 | 0.329 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.468600 | 0.329 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.468600 | 0.329 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.468600 | 0.329 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.471239 | 0.327 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.471239 | 0.327 |
| R-HSA-69242 | S Phase | 0.471337 | 0.327 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.476742 | 0.322 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.476742 | 0.322 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.476742 | 0.322 |
| R-HSA-1280218 | Adaptive Immune System | 0.478338 | 0.320 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.484760 | 0.314 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.484760 | 0.314 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.484760 | 0.314 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.484760 | 0.314 |
| R-HSA-446728 | Cell junction organization | 0.485821 | 0.314 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.486167 | 0.313 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.486936 | 0.313 |
| R-HSA-69306 | DNA Replication | 0.490801 | 0.309 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.490801 | 0.309 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.491084 | 0.309 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.492656 | 0.307 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.492656 | 0.307 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.492656 | 0.307 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.494556 | 0.306 |
| R-HSA-9658195 | Leishmania infection | 0.494556 | 0.306 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.495972 | 0.305 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.497456 | 0.303 |
| R-HSA-73927 | Depurination | 0.500431 | 0.301 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.500431 | 0.301 |
| R-HSA-1566948 | Elastic fibre formation | 0.500431 | 0.301 |
| R-HSA-190236 | Signaling by FGFR | 0.500831 | 0.300 |
| R-HSA-9824446 | Viral Infection Pathways | 0.503570 | 0.298 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.508087 | 0.294 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.508087 | 0.294 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.508087 | 0.294 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.508087 | 0.294 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.508087 | 0.294 |
| R-HSA-201556 | Signaling by ALK | 0.508087 | 0.294 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.508087 | 0.294 |
| R-HSA-168249 | Innate Immune System | 0.513873 | 0.289 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.515626 | 0.288 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.515626 | 0.288 |
| R-HSA-167169 | HIV Transcription Elongation | 0.515626 | 0.288 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.515626 | 0.288 |
| R-HSA-9646399 | Aggrephagy | 0.515626 | 0.288 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.515626 | 0.288 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.515626 | 0.288 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.515626 | 0.288 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.515626 | 0.288 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.515626 | 0.288 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.515626 | 0.288 |
| R-HSA-597592 | Post-translational protein modification | 0.519986 | 0.284 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.523051 | 0.281 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.523051 | 0.281 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.523051 | 0.281 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.523051 | 0.281 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.523051 | 0.281 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.523051 | 0.281 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.523051 | 0.281 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.529341 | 0.276 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.530362 | 0.275 |
| R-HSA-167161 | HIV Transcription Initiation | 0.530362 | 0.275 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.530362 | 0.275 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.530362 | 0.275 |
| R-HSA-73894 | DNA Repair | 0.531993 | 0.274 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.533985 | 0.272 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.533985 | 0.272 |
| R-HSA-9833110 | RSV-host interactions | 0.533985 | 0.272 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.537561 | 0.270 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.537561 | 0.270 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.538598 | 0.269 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.539654 | 0.268 |
| R-HSA-72766 | Translation | 0.541852 | 0.266 |
| R-HSA-5619102 | SLC transporter disorders | 0.543335 | 0.265 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.544651 | 0.264 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.544651 | 0.264 |
| R-HSA-8854214 | TBC/RABGAPs | 0.544651 | 0.264 |
| R-HSA-2172127 | DAP12 interactions | 0.551632 | 0.258 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.551632 | 0.258 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.551632 | 0.258 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.551632 | 0.258 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.551632 | 0.258 |
| R-HSA-392499 | Metabolism of proteins | 0.557109 | 0.254 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.558506 | 0.253 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.558506 | 0.253 |
| R-HSA-774815 | Nucleosome assembly | 0.558506 | 0.253 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.558506 | 0.253 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.558506 | 0.253 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.558506 | 0.253 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.558506 | 0.253 |
| R-HSA-418555 | G alpha (s) signalling events | 0.561327 | 0.251 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.565276 | 0.248 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.565276 | 0.248 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.565276 | 0.248 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.568404 | 0.245 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.568404 | 0.245 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.571916 | 0.243 |
| R-HSA-1483191 | Synthesis of PC | 0.571942 | 0.243 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.574356 | 0.241 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.575411 | 0.240 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.578507 | 0.238 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.578507 | 0.238 |
| R-HSA-425410 | Metal ion SLC transporters | 0.578507 | 0.238 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.578682 | 0.238 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.578682 | 0.238 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.584971 | 0.233 |
| R-HSA-73893 | DNA Damage Bypass | 0.584971 | 0.233 |
| R-HSA-9766229 | Degradation of CDH1 | 0.584971 | 0.233 |
| R-HSA-913531 | Interferon Signaling | 0.591679 | 0.228 |
| R-HSA-2559583 | Cellular Senescence | 0.592615 | 0.227 |
| R-HSA-373760 | L1CAM interactions | 0.595663 | 0.225 |
| R-HSA-9609646 | HCMV Infection | 0.598653 | 0.223 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.599828 | 0.222 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.603777 | 0.219 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.603777 | 0.219 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.603777 | 0.219 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.603777 | 0.219 |
| R-HSA-5693538 | Homology Directed Repair | 0.603961 | 0.219 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.609855 | 0.215 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.609855 | 0.215 |
| R-HSA-68875 | Mitotic Prophase | 0.612130 | 0.213 |
| R-HSA-69275 | G2/M Transition | 0.612659 | 0.213 |
| R-HSA-73886 | Chromosome Maintenance | 0.616166 | 0.210 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.619193 | 0.208 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.621734 | 0.206 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.621734 | 0.206 |
| R-HSA-983712 | Ion channel transport | 0.622432 | 0.206 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.624142 | 0.205 |
| R-HSA-5617833 | Cilium Assembly | 0.625652 | 0.204 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.627537 | 0.202 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.627537 | 0.202 |
| R-HSA-5578775 | Ion homeostasis | 0.627537 | 0.202 |
| R-HSA-977606 | Regulation of Complement cascade | 0.631989 | 0.199 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.633252 | 0.198 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.633252 | 0.198 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.633252 | 0.198 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.638880 | 0.195 |
| R-HSA-180786 | Extension of Telomeres | 0.644422 | 0.191 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.644422 | 0.191 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.644577 | 0.191 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.649879 | 0.187 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.649879 | 0.187 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.649879 | 0.187 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.649879 | 0.187 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.649879 | 0.187 |
| R-HSA-379724 | tRNA Aminoacylation | 0.649879 | 0.187 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.649879 | 0.187 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.655252 | 0.184 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.655252 | 0.184 |
| R-HSA-1474165 | Reproduction | 0.658452 | 0.181 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.660544 | 0.180 |
| R-HSA-1268020 | Mitochondrial protein import | 0.660544 | 0.180 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.660544 | 0.180 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.664735 | 0.177 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.665754 | 0.177 |
| R-HSA-8848021 | Signaling by PTK6 | 0.665754 | 0.177 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.668533 | 0.175 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.669320 | 0.174 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.670885 | 0.173 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.675937 | 0.170 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.675937 | 0.170 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.680913 | 0.167 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.685812 | 0.164 |
| R-HSA-167172 | Transcription of the HIV genome | 0.690636 | 0.161 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.690636 | 0.161 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.690636 | 0.161 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.695386 | 0.158 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.700064 | 0.155 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.702107 | 0.154 |
| R-HSA-3000178 | ECM proteoglycans | 0.704670 | 0.152 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.704670 | 0.152 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.706795 | 0.151 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.709206 | 0.149 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.709206 | 0.149 |
| R-HSA-418990 | Adherens junctions interactions | 0.710796 | 0.148 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.713217 | 0.147 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.713672 | 0.147 |
| R-HSA-166658 | Complement cascade | 0.716384 | 0.145 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.718070 | 0.144 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.718070 | 0.144 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.718070 | 0.144 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.718492 | 0.144 |
| R-HSA-8951664 | Neddylation | 0.718697 | 0.143 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.722401 | 0.141 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.722401 | 0.141 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.722401 | 0.141 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.726665 | 0.139 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.731493 | 0.136 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.731780 | 0.136 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.734999 | 0.134 |
| R-HSA-4086400 | PCP/CE pathway | 0.734999 | 0.134 |
| R-HSA-216083 | Integrin cell surface interactions | 0.734999 | 0.134 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.739071 | 0.131 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.743080 | 0.129 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.747028 | 0.127 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.747028 | 0.127 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.750916 | 0.124 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.750916 | 0.124 |
| R-HSA-162587 | HIV Life Cycle | 0.752142 | 0.124 |
| R-HSA-9610379 | HCMV Late Events | 0.752142 | 0.124 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.754744 | 0.122 |
| R-HSA-877300 | Interferon gamma signaling | 0.757711 | 0.120 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.758514 | 0.120 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.760455 | 0.119 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.762225 | 0.118 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.762225 | 0.118 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.762225 | 0.118 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.769479 | 0.114 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.769479 | 0.114 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.772927 | 0.112 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.773023 | 0.112 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.776513 | 0.110 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.779949 | 0.108 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.780296 | 0.108 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.783332 | 0.106 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.786664 | 0.104 |
| R-HSA-421270 | Cell-cell junction organization | 0.788719 | 0.103 |
| R-HSA-72306 | tRNA processing | 0.788905 | 0.103 |
| R-HSA-5688426 | Deubiquitination | 0.796874 | 0.099 |
| R-HSA-1474290 | Collagen formation | 0.799489 | 0.097 |
| R-HSA-157579 | Telomere Maintenance | 0.811545 | 0.091 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.811545 | 0.091 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.814444 | 0.089 |
| R-HSA-422356 | Regulation of insulin secretion | 0.814444 | 0.089 |
| R-HSA-1643685 | Disease | 0.816999 | 0.088 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.817299 | 0.088 |
| R-HSA-70171 | Glycolysis | 0.820111 | 0.086 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.820111 | 0.086 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.825605 | 0.083 |
| R-HSA-1483255 | PI Metabolism | 0.825605 | 0.083 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.837021 | 0.077 |
| R-HSA-418346 | Platelet homeostasis | 0.838620 | 0.076 |
| R-HSA-211000 | Gene Silencing by RNA | 0.841104 | 0.075 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.843551 | 0.074 |
| R-HSA-382551 | Transport of small molecules | 0.850543 | 0.070 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.852967 | 0.069 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.852967 | 0.069 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.859657 | 0.066 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.863947 | 0.064 |
| R-HSA-70326 | Glucose metabolism | 0.868107 | 0.061 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.868107 | 0.061 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.872140 | 0.059 |
| R-HSA-397014 | Muscle contraction | 0.873493 | 0.059 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.881694 | 0.055 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.881694 | 0.055 |
| R-HSA-114608 | Platelet degranulation | 0.888822 | 0.051 |
| R-HSA-5663205 | Infectious disease | 0.889468 | 0.051 |
| R-HSA-162906 | HIV Infection | 0.894788 | 0.048 |
| R-HSA-5576891 | Cardiac conduction | 0.897133 | 0.047 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.898720 | 0.046 |
| R-HSA-8957322 | Metabolism of steroids | 0.900780 | 0.045 |
| R-HSA-163685 | Integration of energy metabolism | 0.906294 | 0.043 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.906294 | 0.043 |
| R-HSA-1474244 | Extracellular matrix organization | 0.908060 | 0.042 |
| R-HSA-157118 | Signaling by NOTCH | 0.910505 | 0.041 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.917257 | 0.038 |
| R-HSA-9758941 | Gastrulation | 0.924632 | 0.034 |
| R-HSA-388396 | GPCR downstream signalling | 0.925747 | 0.034 |
| R-HSA-372790 | Signaling by GPCR | 0.927461 | 0.033 |
| R-HSA-2142753 | Arachidonate metabolism | 0.928070 | 0.032 |
| R-HSA-9609507 | Protein localization | 0.929181 | 0.032 |
| R-HSA-109582 | Hemostasis | 0.931486 | 0.031 |
| R-HSA-416476 | G alpha (q) signalling events | 0.933916 | 0.030 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.936494 | 0.028 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.942918 | 0.026 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.948939 | 0.023 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.948939 | 0.023 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.948939 | 0.023 |
| R-HSA-1483257 | Phospholipid metabolism | 0.955678 | 0.020 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.956311 | 0.019 |
| R-HSA-195721 | Signaling by WNT | 0.957377 | 0.019 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.958308 | 0.018 |
| R-HSA-428157 | Sphingolipid metabolism | 0.967010 | 0.015 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.968024 | 0.014 |
| R-HSA-6805567 | Keratinization | 0.969961 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.969988 | 0.013 |
| R-HSA-9748784 | Drug ADME | 0.975097 | 0.011 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.975833 | 0.011 |
| R-HSA-15869 | Metabolism of nucleotides | 0.981207 | 0.008 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.981499 | 0.008 |
| R-HSA-500792 | GPCR ligand binding | 0.985341 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.988347 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 0.990248 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.990269 | 0.004 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.995202 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.995817 | 0.002 |
| R-HSA-74160 | Gene expression (Transcription) | 0.996579 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 0.996618 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998358 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998745 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.999086 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.999118 | 0.000 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.999414 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999801 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999850 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.895 | 0.206 | 2 | 0.860 |
PIM3 |
0.883 | 0.154 | -3 | 0.847 |
CDC7 |
0.883 | 0.125 | 1 | 0.867 |
CLK3 |
0.882 | 0.208 | 1 | 0.821 |
MOS |
0.882 | 0.209 | 1 | 0.884 |
NDR2 |
0.876 | 0.088 | -3 | 0.849 |
SKMLCK |
0.876 | 0.193 | -2 | 0.923 |
PRPK |
0.875 | -0.065 | -1 | 0.844 |
DSTYK |
0.875 | 0.055 | 2 | 0.869 |
RAF1 |
0.874 | 0.001 | 1 | 0.860 |
CAMK1B |
0.874 | 0.078 | -3 | 0.864 |
PKN3 |
0.873 | 0.091 | -3 | 0.851 |
MST4 |
0.873 | 0.136 | 2 | 0.859 |
PRKD1 |
0.873 | 0.166 | -3 | 0.833 |
RSK2 |
0.873 | 0.130 | -3 | 0.780 |
RIPK3 |
0.872 | 0.054 | 3 | 0.761 |
PRKD2 |
0.872 | 0.167 | -3 | 0.789 |
ULK2 |
0.872 | -0.022 | 2 | 0.776 |
IKKB |
0.872 | -0.044 | -2 | 0.762 |
GCN2 |
0.871 | -0.073 | 2 | 0.776 |
NDR1 |
0.871 | 0.078 | -3 | 0.847 |
PIM1 |
0.871 | 0.142 | -3 | 0.800 |
NEK6 |
0.871 | 0.092 | -2 | 0.890 |
NLK |
0.871 | 0.047 | 1 | 0.815 |
TGFBR2 |
0.871 | 0.057 | -2 | 0.839 |
TBK1 |
0.870 | -0.036 | 1 | 0.761 |
NUAK2 |
0.870 | 0.087 | -3 | 0.854 |
BMPR2 |
0.870 | -0.006 | -2 | 0.914 |
AMPKA1 |
0.870 | 0.126 | -3 | 0.869 |
CDKL1 |
0.870 | 0.068 | -3 | 0.808 |
PKN2 |
0.870 | 0.105 | -3 | 0.854 |
AURC |
0.870 | 0.185 | -2 | 0.746 |
WNK1 |
0.870 | 0.065 | -2 | 0.917 |
CDKL5 |
0.869 | 0.121 | -3 | 0.803 |
MLK1 |
0.869 | 0.022 | 2 | 0.804 |
MTOR |
0.869 | -0.081 | 1 | 0.784 |
CAMLCK |
0.869 | 0.108 | -2 | 0.909 |
PDHK4 |
0.869 | -0.218 | 1 | 0.861 |
PKCD |
0.869 | 0.132 | 2 | 0.788 |
SRPK1 |
0.869 | 0.116 | -3 | 0.764 |
CAMK2G |
0.868 | -0.055 | 2 | 0.781 |
NIK |
0.867 | 0.061 | -3 | 0.886 |
PKACG |
0.867 | 0.126 | -2 | 0.834 |
ERK5 |
0.867 | 0.073 | 1 | 0.822 |
ATR |
0.867 | -0.030 | 1 | 0.825 |
NEK7 |
0.867 | -0.037 | -3 | 0.818 |
IKKE |
0.866 | -0.065 | 1 | 0.760 |
RSK3 |
0.866 | 0.091 | -3 | 0.779 |
TSSK2 |
0.866 | 0.145 | -5 | 0.883 |
CHAK2 |
0.865 | 0.050 | -1 | 0.830 |
P70S6KB |
0.865 | 0.095 | -3 | 0.808 |
GRK1 |
0.865 | 0.123 | -2 | 0.838 |
P90RSK |
0.865 | 0.075 | -3 | 0.790 |
BMPR1B |
0.865 | 0.195 | 1 | 0.835 |
MARK4 |
0.865 | 0.028 | 4 | 0.877 |
PDHK1 |
0.865 | -0.167 | 1 | 0.854 |
DAPK2 |
0.865 | 0.085 | -3 | 0.869 |
TSSK1 |
0.864 | 0.137 | -3 | 0.885 |
HIPK4 |
0.864 | 0.092 | 1 | 0.787 |
MAPKAPK3 |
0.864 | 0.072 | -3 | 0.794 |
GRK5 |
0.864 | -0.075 | -3 | 0.847 |
AMPKA2 |
0.863 | 0.099 | -3 | 0.838 |
FAM20C |
0.862 | 0.124 | 2 | 0.623 |
MNK2 |
0.862 | 0.147 | -2 | 0.859 |
CAMK2D |
0.862 | 0.027 | -3 | 0.850 |
ICK |
0.862 | 0.080 | -3 | 0.842 |
MLK3 |
0.861 | 0.068 | 2 | 0.747 |
LATS2 |
0.860 | 0.019 | -5 | 0.734 |
PAK1 |
0.860 | 0.088 | -2 | 0.853 |
MAPKAPK2 |
0.860 | 0.085 | -3 | 0.749 |
SRPK2 |
0.860 | 0.096 | -3 | 0.688 |
NEK9 |
0.859 | -0.040 | 2 | 0.825 |
CAMK2B |
0.859 | 0.087 | 2 | 0.756 |
IRE1 |
0.859 | 0.023 | 1 | 0.827 |
WNK3 |
0.859 | -0.153 | 1 | 0.835 |
ANKRD3 |
0.859 | -0.028 | 1 | 0.880 |
AURB |
0.859 | 0.140 | -2 | 0.743 |
IKKA |
0.859 | -0.001 | -2 | 0.747 |
MLK2 |
0.859 | 0.008 | 2 | 0.818 |
GRK6 |
0.859 | -0.015 | 1 | 0.857 |
PKCB |
0.859 | 0.094 | 2 | 0.744 |
PKG2 |
0.858 | 0.155 | -2 | 0.768 |
KIS |
0.858 | 0.025 | 1 | 0.670 |
ULK1 |
0.858 | -0.130 | -3 | 0.819 |
HUNK |
0.858 | -0.097 | 2 | 0.765 |
PRKD3 |
0.858 | 0.102 | -3 | 0.751 |
IRE2 |
0.857 | 0.045 | 2 | 0.751 |
PKCA |
0.857 | 0.103 | 2 | 0.734 |
PKR |
0.857 | 0.135 | 1 | 0.865 |
RSK4 |
0.857 | 0.117 | -3 | 0.756 |
RIPK1 |
0.857 | -0.090 | 1 | 0.845 |
CAMK4 |
0.856 | 0.006 | -3 | 0.835 |
PKCG |
0.856 | 0.072 | 2 | 0.743 |
PKACB |
0.856 | 0.149 | -2 | 0.767 |
BCKDK |
0.856 | -0.150 | -1 | 0.772 |
LATS1 |
0.856 | 0.100 | -3 | 0.850 |
PAK3 |
0.855 | 0.037 | -2 | 0.848 |
MELK |
0.855 | 0.045 | -3 | 0.821 |
TGFBR1 |
0.855 | 0.101 | -2 | 0.829 |
CAMK2A |
0.855 | 0.064 | 2 | 0.769 |
ALK4 |
0.855 | 0.052 | -2 | 0.858 |
PLK1 |
0.855 | 0.019 | -2 | 0.847 |
MASTL |
0.855 | -0.207 | -2 | 0.855 |
GRK4 |
0.855 | -0.070 | -2 | 0.872 |
PRKX |
0.855 | 0.177 | -3 | 0.709 |
AURA |
0.854 | 0.133 | -2 | 0.712 |
MNK1 |
0.854 | 0.112 | -2 | 0.872 |
MYLK4 |
0.854 | 0.082 | -2 | 0.848 |
ATM |
0.853 | -0.018 | 1 | 0.763 |
CLK4 |
0.853 | 0.102 | -3 | 0.782 |
DLK |
0.853 | -0.128 | 1 | 0.855 |
SRPK3 |
0.853 | 0.063 | -3 | 0.732 |
TTBK2 |
0.853 | -0.124 | 2 | 0.693 |
MSK2 |
0.853 | 0.029 | -3 | 0.752 |
PKCH |
0.853 | 0.057 | 2 | 0.723 |
PKCZ |
0.852 | 0.053 | 2 | 0.785 |
SGK3 |
0.852 | 0.116 | -3 | 0.786 |
PHKG1 |
0.852 | 0.016 | -3 | 0.841 |
QSK |
0.852 | 0.030 | 4 | 0.857 |
MLK4 |
0.852 | 0.004 | 2 | 0.716 |
NUAK1 |
0.851 | 0.003 | -3 | 0.805 |
NIM1 |
0.851 | -0.089 | 3 | 0.767 |
DYRK2 |
0.851 | 0.064 | 1 | 0.687 |
CLK1 |
0.851 | 0.102 | -3 | 0.760 |
GRK7 |
0.851 | 0.090 | 1 | 0.769 |
NEK2 |
0.851 | -0.004 | 2 | 0.814 |
MSK1 |
0.851 | 0.083 | -3 | 0.763 |
PAK6 |
0.850 | 0.087 | -2 | 0.766 |
QIK |
0.850 | -0.047 | -3 | 0.839 |
ALK2 |
0.850 | 0.093 | -2 | 0.840 |
AKT2 |
0.850 | 0.110 | -3 | 0.705 |
ACVR2A |
0.850 | 0.061 | -2 | 0.821 |
PIM2 |
0.849 | 0.101 | -3 | 0.761 |
CLK2 |
0.849 | 0.156 | -3 | 0.770 |
PAK2 |
0.849 | 0.023 | -2 | 0.837 |
SIK |
0.849 | 0.014 | -3 | 0.772 |
PRP4 |
0.849 | 0.270 | -3 | 0.907 |
ACVR2B |
0.848 | 0.065 | -2 | 0.833 |
BRSK1 |
0.848 | 0.009 | -3 | 0.808 |
CDK8 |
0.848 | -0.019 | 1 | 0.641 |
CHAK1 |
0.848 | -0.056 | 2 | 0.794 |
BMPR1A |
0.847 | 0.143 | 1 | 0.816 |
YSK4 |
0.847 | -0.066 | 1 | 0.797 |
VRK2 |
0.846 | -0.092 | 1 | 0.887 |
BRSK2 |
0.846 | -0.022 | -3 | 0.832 |
MARK3 |
0.845 | 0.021 | 4 | 0.818 |
CHK1 |
0.845 | 0.036 | -3 | 0.841 |
TLK2 |
0.845 | -0.018 | 1 | 0.817 |
MEK1 |
0.844 | -0.159 | 2 | 0.823 |
MARK2 |
0.844 | 0.008 | 4 | 0.783 |
CDK7 |
0.844 | -0.018 | 1 | 0.641 |
MST3 |
0.843 | 0.102 | 2 | 0.836 |
DRAK1 |
0.843 | -0.017 | 1 | 0.781 |
CDK5 |
0.843 | 0.023 | 1 | 0.658 |
DCAMKL1 |
0.843 | 0.041 | -3 | 0.805 |
HIPK1 |
0.842 | 0.075 | 1 | 0.703 |
PKACA |
0.842 | 0.124 | -2 | 0.718 |
PERK |
0.842 | -0.030 | -2 | 0.866 |
CDK1 |
0.842 | 0.018 | 1 | 0.593 |
CAMK1G |
0.842 | 0.010 | -3 | 0.772 |
SMG1 |
0.842 | -0.070 | 1 | 0.771 |
P38A |
0.842 | 0.032 | 1 | 0.686 |
HIPK2 |
0.842 | 0.073 | 1 | 0.589 |
HRI |
0.841 | -0.070 | -2 | 0.885 |
PKCT |
0.841 | 0.052 | 2 | 0.735 |
AKT1 |
0.841 | 0.113 | -3 | 0.727 |
MEKK2 |
0.841 | 0.010 | 2 | 0.797 |
PLK3 |
0.841 | -0.065 | 2 | 0.738 |
SSTK |
0.841 | 0.066 | 4 | 0.845 |
MEKK1 |
0.841 | -0.040 | 1 | 0.841 |
DNAPK |
0.841 | -0.022 | 1 | 0.688 |
CDK19 |
0.841 | -0.024 | 1 | 0.598 |
IRAK4 |
0.841 | -0.014 | 1 | 0.838 |
JNK2 |
0.841 | 0.032 | 1 | 0.581 |
BRAF |
0.840 | -0.032 | -4 | 0.851 |
WNK4 |
0.840 | -0.042 | -2 | 0.902 |
SMMLCK |
0.840 | 0.051 | -3 | 0.826 |
JNK3 |
0.840 | 0.006 | 1 | 0.620 |
CDK18 |
0.840 | 0.025 | 1 | 0.563 |
NEK5 |
0.840 | 0.008 | 1 | 0.854 |
ZAK |
0.839 | -0.051 | 1 | 0.819 |
MEKK3 |
0.839 | -0.092 | 1 | 0.829 |
SNRK |
0.838 | -0.149 | 2 | 0.652 |
MAPKAPK5 |
0.838 | -0.076 | -3 | 0.733 |
CDK13 |
0.838 | -0.029 | 1 | 0.611 |
MARK1 |
0.838 | -0.038 | 4 | 0.835 |
MEK5 |
0.837 | -0.157 | 2 | 0.813 |
PKCI |
0.837 | 0.051 | 2 | 0.756 |
TAO3 |
0.837 | 0.037 | 1 | 0.811 |
P70S6K |
0.836 | 0.029 | -3 | 0.720 |
P38B |
0.836 | 0.025 | 1 | 0.610 |
TLK1 |
0.836 | -0.053 | -2 | 0.865 |
HIPK3 |
0.836 | 0.032 | 1 | 0.704 |
GRK2 |
0.836 | -0.059 | -2 | 0.747 |
PKCE |
0.836 | 0.100 | 2 | 0.730 |
PLK4 |
0.836 | -0.113 | 2 | 0.602 |
DYRK1A |
0.835 | 0.025 | 1 | 0.714 |
CK1E |
0.835 | -0.007 | -3 | 0.536 |
PAK5 |
0.835 | 0.060 | -2 | 0.714 |
DYRK3 |
0.835 | 0.085 | 1 | 0.715 |
CAMK1D |
0.835 | 0.056 | -3 | 0.707 |
DAPK3 |
0.834 | 0.098 | -3 | 0.814 |
ERK1 |
0.834 | -0.006 | 1 | 0.597 |
MPSK1 |
0.834 | 0.063 | 1 | 0.802 |
PASK |
0.834 | 0.017 | -3 | 0.855 |
PINK1 |
0.834 | -0.135 | 1 | 0.826 |
PHKG2 |
0.833 | -0.015 | -3 | 0.814 |
P38G |
0.833 | 0.012 | 1 | 0.503 |
CDK2 |
0.833 | -0.043 | 1 | 0.677 |
CDK12 |
0.832 | -0.015 | 1 | 0.584 |
GSK3A |
0.832 | 0.093 | 4 | 0.516 |
NEK8 |
0.832 | -0.061 | 2 | 0.807 |
GAK |
0.831 | 0.059 | 1 | 0.849 |
LKB1 |
0.831 | 0.075 | -3 | 0.864 |
DCAMKL2 |
0.831 | -0.033 | -3 | 0.821 |
CDK17 |
0.831 | -0.015 | 1 | 0.505 |
ERK2 |
0.831 | -0.056 | 1 | 0.641 |
ROCK2 |
0.831 | 0.158 | -3 | 0.811 |
PAK4 |
0.830 | 0.054 | -2 | 0.721 |
CDK9 |
0.830 | -0.053 | 1 | 0.620 |
AKT3 |
0.830 | 0.110 | -3 | 0.646 |
GSK3B |
0.830 | 0.036 | 4 | 0.508 |
MRCKB |
0.830 | 0.123 | -3 | 0.759 |
CDK3 |
0.830 | 0.027 | 1 | 0.526 |
TAO2 |
0.829 | -0.009 | 2 | 0.842 |
EEF2K |
0.829 | 0.059 | 3 | 0.808 |
PKN1 |
0.829 | 0.043 | -3 | 0.739 |
DYRK4 |
0.828 | 0.026 | 1 | 0.599 |
SGK1 |
0.828 | 0.102 | -3 | 0.631 |
CK2A2 |
0.828 | 0.093 | 1 | 0.725 |
CDK14 |
0.828 | -0.000 | 1 | 0.609 |
CDK10 |
0.828 | 0.034 | 1 | 0.595 |
CK1D |
0.827 | -0.009 | -3 | 0.487 |
DYRK1B |
0.827 | 0.013 | 1 | 0.630 |
GCK |
0.827 | 0.038 | 1 | 0.817 |
PDK1 |
0.827 | -0.039 | 1 | 0.819 |
DAPK1 |
0.827 | 0.074 | -3 | 0.798 |
TNIK |
0.827 | 0.069 | 3 | 0.822 |
CAMKK1 |
0.826 | -0.123 | -2 | 0.761 |
MRCKA |
0.826 | 0.104 | -3 | 0.773 |
TTBK1 |
0.826 | -0.169 | 2 | 0.612 |
HGK |
0.825 | 0.010 | 3 | 0.826 |
NEK4 |
0.825 | -0.067 | 1 | 0.817 |
BUB1 |
0.825 | 0.146 | -5 | 0.815 |
MINK |
0.825 | 0.015 | 1 | 0.820 |
ERK7 |
0.825 | 0.026 | 2 | 0.553 |
NEK11 |
0.825 | -0.160 | 1 | 0.815 |
MST2 |
0.824 | -0.026 | 1 | 0.830 |
CHK2 |
0.824 | 0.043 | -3 | 0.656 |
IRAK1 |
0.824 | -0.227 | -1 | 0.757 |
CAMKK2 |
0.824 | -0.076 | -2 | 0.760 |
GRK3 |
0.824 | -0.043 | -2 | 0.706 |
CK1G1 |
0.824 | -0.065 | -3 | 0.523 |
CDK16 |
0.823 | 0.021 | 1 | 0.521 |
MAK |
0.823 | 0.118 | -2 | 0.784 |
HPK1 |
0.823 | 0.017 | 1 | 0.802 |
CK1A2 |
0.823 | -0.029 | -3 | 0.486 |
VRK1 |
0.823 | 0.009 | 2 | 0.828 |
LOK |
0.822 | 0.000 | -2 | 0.819 |
NEK1 |
0.822 | -0.000 | 1 | 0.830 |
MEKK6 |
0.821 | -0.059 | 1 | 0.830 |
TAK1 |
0.821 | -0.051 | 1 | 0.842 |
MOK |
0.821 | 0.108 | 1 | 0.737 |
CAMK1A |
0.821 | 0.048 | -3 | 0.672 |
P38D |
0.820 | 0.002 | 1 | 0.523 |
KHS1 |
0.820 | 0.053 | 1 | 0.801 |
KHS2 |
0.820 | 0.077 | 1 | 0.806 |
LRRK2 |
0.819 | -0.103 | 2 | 0.835 |
DMPK1 |
0.818 | 0.134 | -3 | 0.775 |
MAP3K15 |
0.818 | -0.091 | 1 | 0.796 |
CK2A1 |
0.817 | 0.070 | 1 | 0.702 |
YSK1 |
0.817 | -0.001 | 2 | 0.809 |
ROCK1 |
0.816 | 0.117 | -3 | 0.777 |
MST1 |
0.816 | -0.054 | 1 | 0.814 |
PKG1 |
0.816 | 0.076 | -2 | 0.684 |
PBK |
0.815 | 0.038 | 1 | 0.778 |
PLK2 |
0.814 | -0.042 | -3 | 0.777 |
TTK |
0.814 | 0.057 | -2 | 0.868 |
SLK |
0.814 | -0.071 | -2 | 0.762 |
CDK6 |
0.813 | -0.016 | 1 | 0.589 |
STK33 |
0.813 | -0.144 | 2 | 0.601 |
CDK4 |
0.813 | -0.013 | 1 | 0.566 |
JNK1 |
0.811 | -0.044 | 1 | 0.561 |
SBK |
0.811 | 0.040 | -3 | 0.587 |
RIPK2 |
0.811 | -0.231 | 1 | 0.774 |
OSR1 |
0.809 | 0.011 | 2 | 0.800 |
CRIK |
0.809 | 0.083 | -3 | 0.721 |
MEK2 |
0.809 | -0.221 | 2 | 0.798 |
NEK3 |
0.808 | -0.070 | 1 | 0.798 |
MYO3B |
0.807 | 0.058 | 2 | 0.833 |
HASPIN |
0.806 | 0.006 | -1 | 0.655 |
PDHK3_TYR |
0.805 | 0.186 | 4 | 0.923 |
MYO3A |
0.800 | -0.025 | 1 | 0.810 |
BIKE |
0.800 | 0.031 | 1 | 0.723 |
TAO1 |
0.799 | -0.031 | 1 | 0.753 |
TESK1_TYR |
0.797 | 0.003 | 3 | 0.848 |
ALPHAK3 |
0.797 | -0.061 | -1 | 0.789 |
MAP2K4_TYR |
0.797 | 0.003 | -1 | 0.871 |
LIMK2_TYR |
0.795 | 0.086 | -3 | 0.896 |
PKMYT1_TYR |
0.795 | -0.012 | 3 | 0.837 |
MAP2K6_TYR |
0.795 | -0.006 | -1 | 0.876 |
PDHK4_TYR |
0.794 | 0.012 | 2 | 0.860 |
ASK1 |
0.794 | -0.157 | 1 | 0.782 |
BMPR2_TYR |
0.793 | 0.005 | -1 | 0.850 |
PDHK1_TYR |
0.792 | -0.006 | -1 | 0.895 |
MAP2K7_TYR |
0.792 | -0.174 | 2 | 0.835 |
PINK1_TYR |
0.791 | -0.125 | 1 | 0.848 |
CK1A |
0.791 | -0.032 | -3 | 0.394 |
RET |
0.790 | -0.005 | 1 | 0.823 |
EPHA6 |
0.790 | 0.069 | -1 | 0.857 |
YANK3 |
0.789 | -0.099 | 2 | 0.392 |
ABL2 |
0.788 | 0.081 | -1 | 0.825 |
EPHB4 |
0.787 | 0.044 | -1 | 0.839 |
ROS1 |
0.787 | -0.004 | 3 | 0.763 |
TXK |
0.786 | 0.115 | 1 | 0.857 |
TYK2 |
0.786 | -0.087 | 1 | 0.827 |
TYRO3 |
0.785 | -0.058 | 3 | 0.779 |
FGR |
0.785 | 0.026 | 1 | 0.866 |
LIMK1_TYR |
0.784 | -0.137 | 2 | 0.842 |
MST1R |
0.784 | -0.074 | 3 | 0.784 |
STLK3 |
0.784 | -0.171 | 1 | 0.778 |
TNNI3K_TYR |
0.784 | 0.121 | 1 | 0.861 |
BLK |
0.783 | 0.121 | -1 | 0.831 |
JAK2 |
0.783 | -0.070 | 1 | 0.824 |
YES1 |
0.783 | -0.006 | -1 | 0.828 |
DDR1 |
0.783 | -0.088 | 4 | 0.843 |
CSF1R |
0.783 | -0.045 | 3 | 0.775 |
TNK2 |
0.782 | 0.017 | 3 | 0.737 |
ABL1 |
0.782 | 0.044 | -1 | 0.817 |
LCK |
0.782 | 0.080 | -1 | 0.817 |
AAK1 |
0.782 | 0.062 | 1 | 0.616 |
JAK3 |
0.781 | -0.034 | 1 | 0.809 |
HCK |
0.780 | -0.002 | -1 | 0.821 |
INSRR |
0.780 | -0.045 | 3 | 0.735 |
ITK |
0.780 | 0.021 | -1 | 0.801 |
PDGFRB |
0.778 | -0.075 | 3 | 0.784 |
FER |
0.778 | -0.089 | 1 | 0.880 |
SRMS |
0.777 | -0.023 | 1 | 0.873 |
JAK1 |
0.777 | 0.010 | 1 | 0.774 |
EPHB1 |
0.776 | -0.027 | 1 | 0.878 |
KDR |
0.776 | -0.048 | 3 | 0.744 |
TNK1 |
0.775 | -0.035 | 3 | 0.766 |
NEK10_TYR |
0.775 | -0.061 | 1 | 0.694 |
FGFR2 |
0.774 | -0.108 | 3 | 0.770 |
EPHA4 |
0.774 | -0.044 | 2 | 0.735 |
KIT |
0.774 | -0.105 | 3 | 0.774 |
EPHB3 |
0.773 | -0.031 | -1 | 0.826 |
EPHB2 |
0.773 | -0.011 | -1 | 0.825 |
TEC |
0.773 | -0.027 | -1 | 0.750 |
FLT3 |
0.772 | -0.125 | 3 | 0.776 |
BMX |
0.771 | -0.023 | -1 | 0.715 |
DDR2 |
0.771 | 0.038 | 3 | 0.722 |
AXL |
0.771 | -0.098 | 3 | 0.752 |
FYN |
0.771 | 0.021 | -1 | 0.783 |
ALK |
0.770 | -0.085 | 3 | 0.708 |
MERTK |
0.770 | -0.060 | 3 | 0.750 |
MET |
0.770 | -0.074 | 3 | 0.750 |
FGFR1 |
0.769 | -0.135 | 3 | 0.749 |
WEE1_TYR |
0.769 | -0.079 | -1 | 0.737 |
LTK |
0.768 | -0.083 | 3 | 0.733 |
BTK |
0.768 | -0.142 | -1 | 0.770 |
PDGFRA |
0.768 | -0.160 | 3 | 0.785 |
FLT1 |
0.768 | -0.063 | -1 | 0.854 |
TEK |
0.768 | -0.159 | 3 | 0.723 |
CK1G3 |
0.767 | -0.075 | -3 | 0.348 |
EPHA7 |
0.767 | -0.039 | 2 | 0.740 |
LYN |
0.766 | -0.041 | 3 | 0.728 |
PTK6 |
0.765 | -0.158 | -1 | 0.731 |
FRK |
0.765 | -0.060 | -1 | 0.857 |
NTRK1 |
0.764 | -0.169 | -1 | 0.817 |
FLT4 |
0.763 | -0.134 | 3 | 0.755 |
NTRK2 |
0.762 | -0.180 | 3 | 0.744 |
EPHA1 |
0.762 | -0.098 | 3 | 0.726 |
INSR |
0.762 | -0.141 | 3 | 0.716 |
ERBB2 |
0.761 | -0.161 | 1 | 0.772 |
FGFR3 |
0.761 | -0.158 | 3 | 0.743 |
SRC |
0.759 | -0.058 | -1 | 0.784 |
EPHA3 |
0.759 | -0.147 | 2 | 0.706 |
MATK |
0.759 | -0.113 | -1 | 0.755 |
PTK2B |
0.759 | -0.059 | -1 | 0.775 |
NTRK3 |
0.758 | -0.133 | -1 | 0.766 |
EPHA5 |
0.757 | -0.072 | 2 | 0.716 |
EPHA8 |
0.755 | -0.079 | -1 | 0.802 |
YANK2 |
0.755 | -0.136 | 2 | 0.408 |
EGFR |
0.754 | -0.086 | 1 | 0.684 |
PTK2 |
0.753 | -0.012 | -1 | 0.771 |
SYK |
0.752 | 0.005 | -1 | 0.782 |
CSK |
0.752 | -0.153 | 2 | 0.736 |
FGFR4 |
0.749 | -0.123 | -1 | 0.787 |
CK1G2 |
0.748 | -0.066 | -3 | 0.443 |
IGF1R |
0.746 | -0.147 | 3 | 0.661 |
MUSK |
0.745 | -0.144 | 1 | 0.675 |
EPHA2 |
0.744 | -0.098 | -1 | 0.774 |
ERBB4 |
0.742 | -0.081 | 1 | 0.703 |
FES |
0.729 | -0.178 | -1 | 0.692 |
ZAP70 |
0.725 | -0.090 | -1 | 0.679 |