Motif 666 (n=464)

Position-wise Probabilities

Download

uniprot	genes	site	source	protein	function
A0A0A6YYC7	ZFP91-CNTF	S146	ochoa	E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog)	Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256\|ARBA:ARBA00054990}.
A0JNW5	BLTP3B	S1009	ochoa	Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like)	Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269\|PubMed:20163565, ECO:0000269\|PubMed:35499567}.
A0MZ66	SHTN1	S492	ochoa	Shootin-1 (Shootin1)	Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250\|UniProtKB:A0MZ67, ECO:0000250\|UniProtKB:Q8K2Q9}.
D6RIA3	C4orf54	S889	ochoa	Uncharacterized protein C4orf54 (Familial obliterative portal venopathy)	None
E9PAV3	NACA	S2054	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
H0YHG0	None	S146	ochoa	DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein)	Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256\|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256\|ARBA:ARBA00055510}.
H7C1W4	None	S242	ochoa	Uncharacterized protein	None
H7C1W4	None	S396	ochoa	Uncharacterized protein	None
M0QZ92	None	S40	ochoa	SEC7 domain-containing protein	None
O00472	ELL2	S502	ochoa	RNA polymerase II elongation factor ELL2	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:22195968, ECO:0000269\|PubMed:23251033}.
O00515	LAD1	S39	ochoa\|psp	Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA)	Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.
O00629	KPNA4	S72	ochoa	Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Mediates nuclear import of AARS1, MRTFA and RANBP3 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:38512451). {ECO:0000269\|PubMed:10567565, ECO:0000269\|PubMed:20818336, ECO:0000269\|PubMed:28760339, ECO:0000269\|PubMed:29042532, ECO:0000269\|PubMed:38512451}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269\|PubMed:12610148}.
O14974	PPP1R12A	S445	ochoa\|psp	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269\|PubMed:18477460, ECO:0000269\|PubMed:19245366, ECO:0000269\|PubMed:20354225}.
O15014	ZNF609	S252	ochoa	Zinc finger protein 609	Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250\|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269\|PubMed:28344082}.
O15061	SYNM	S765	ochoa	Synemin (Desmuslin)	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269\|PubMed:11353857, ECO:0000269\|PubMed:16777071, ECO:0000269\|PubMed:18028034}.
O15234	CASC3	S148	ochoa	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269\|PubMed:17375189, ECO:0000269\|PubMed:17652158, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961}.
O15355	PPM1G	S325	ochoa	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	None
O15400	STX7	S131	ochoa	Syntaxin-7	May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
O15516	CLOCK	S406	ochoa	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK\|NPAS2-BMAL1\|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250\|UniProtKB:O08785, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:18587630, ECO:0000269\|PubMed:21659603, ECO:0000269\|PubMed:21980503, ECO:0000269\|PubMed:22284746, ECO:0000269\|PubMed:23229515, ECO:0000269\|PubMed:23785138, ECO:0000269\|PubMed:24005054, ECO:0000269\|PubMed:28985504}.
O43829	ZBTB14	S222	ochoa	Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5)	Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269\|PubMed:17714511}.
O60237	PPP1R12B	S393	ochoa	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)	Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269\|PubMed:11067852, ECO:0000269\|PubMed:9570949}.
O60237	PPP1R12B	S842	ochoa	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)	Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269\|PubMed:11067852, ECO:0000269\|PubMed:9570949}.
O60264	SMARCA5	S171	ochoa	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)	ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250\|UniProtKB:Q91ZW3, ECO:0000269\|PubMed:10880450, ECO:0000269\|PubMed:11980720, ECO:0000269\|PubMed:12198550, ECO:0000269\|PubMed:12434153, ECO:0000269\|PubMed:12972596, ECO:0000269\|PubMed:14759371, ECO:0000269\|PubMed:15543136, ECO:0000269\|PubMed:16603771, ECO:0000269\|PubMed:23911928, ECO:0000269\|PubMed:28801535}.
O60271	SPAG9	S364	ochoa	C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250\|UniProtKB:Q58A65, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:29146937}.
O60934	NBN	S397	ochoa\|psp	Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1)	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269\|PubMed:10888888, ECO:0000269\|PubMed:12419185, ECO:0000269\|PubMed:15064416, ECO:0000269\|PubMed:15616588, ECO:0000269\|PubMed:15790808, ECO:0000269\|PubMed:16622404, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:19759395, ECO:0000269\|PubMed:19804756, ECO:0000269\|PubMed:22464731, ECO:0000269\|PubMed:23115235, ECO:0000269\|PubMed:23762398, ECO:0000269\|PubMed:24534091, ECO:0000269\|PubMed:26438602, ECO:0000269\|PubMed:27814491, ECO:0000269\|PubMed:27889449, ECO:0000269\|PubMed:28216226, ECO:0000269\|PubMed:28867292, ECO:0000269\|PubMed:30787182, ECO:0000269\|PubMed:30952868, ECO:0000269\|PubMed:31537797, ECO:0000269\|PubMed:33836577, ECO:0000269\|PubMed:35076389, ECO:0000269\|PubMed:9705271}.
O75123	ZNF623	S67	ochoa	Zinc finger protein 623	May be involved in transcriptional regulation.
O75153	CLUH	S669	ochoa	Clustered mitochondria protein homolog	mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255\|HAMAP-Rule:MF_03013, ECO:0000269\|PubMed:25349259}.
O75167	PHACTR2	S560	ochoa	Phosphatase and actin regulator 2	None
O75369	FLNB	S1384	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75459	PAGE1	S63	ochoa	P antigen family member 1 (PAGE-1) (AL5) (G antigen 9) (GAGE-9) (G antigen family B member 1) (Prostate-associated gene 1 protein)	None
O75554	WBP4	S323	ochoa	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)	Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269\|PubMed:19592703, ECO:0000269\|PubMed:28781166, ECO:0000269\|PubMed:9724750}.
O75665	OFD1	S973	ochoa	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250\|UniProtKB:Q80Z25, ECO:0000269\|PubMed:33934390}.
O75821	EIF3G	S266	ochoa	Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255\|HAMAP-Rule:MF_03006, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
O75976	CPD	S1361	ochoa	Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)	None
O94763	URI1	S378	ochoa	Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)	Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
O94769	ECM2	S304	ochoa	Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2)	Promotes matrix assembly and cell adhesiveness. {ECO:0000250\|UniProtKB:Q5FW85}.
O94887	FARP2	S1033	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)	Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O95049	TJP3	S368	ochoa	Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250\|UniProtKB:O62683, ECO:0000250\|UniProtKB:Q9QXY1, ECO:0000269\|PubMed:16129888, ECO:0000269\|PubMed:21411630}.
O95260	ATE1	S179	ochoa	Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1)	Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250\|UniProtKB:Q9Z2A5, ECO:0000269\|PubMed:34893540}.
O95613	PCNT	S2326	ochoa	Pericentrin (Kendrin) (Pericentrin-B)	Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269\|PubMed:10823944, ECO:0000269\|PubMed:11171385, ECO:0000269\|PubMed:18955030, ECO:0000269\|PubMed:20599736, ECO:0000269\|PubMed:30420784}.
O95810	CAVIN2	S203	ochoa	Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein)	Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250\|UniProtKB:Q66H98, ECO:0000269\|PubMed:19525939}.
P04920	SLC4A2	S144	ochoa	Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)	Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250\|UniProtKB:P13808, ECO:0000269\|PubMed:15184086, ECO:0000269\|PubMed:34668226}.
P05107	ITGB2	S349	ochoa	Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269\|PubMed:11812992, ECO:0000269\|PubMed:15356110, ECO:0000269\|PubMed:18587400, ECO:0000269\|PubMed:21193407, ECO:0000269\|PubMed:23775590, ECO:0000269\|PubMed:28807980, ECO:0000269\|PubMed:29100055}.
P05455	SSB	S325	ochoa	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269\|PubMed:12384597, ECO:0000269\|PubMed:2470590, ECO:0000269\|PubMed:3192525}.
P05976	MYL1	S68	ochoa	Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2)	Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269\|PubMed:30215711}.
P08183	ABCB1	S661	ochoa\|psp	ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243)	Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). {ECO:0000269\|PubMed:2897240, ECO:0000269\|PubMed:35507548, ECO:0000269\|PubMed:35970996, ECO:0000269\|PubMed:8898203, ECO:0000269\|PubMed:9038218}.
P09874	PARP1	S277	ochoa	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250\|UniProtKB:P11103, ECO:0000269\|PubMed:15607977, ECO:0000269\|PubMed:17177976, ECO:0000269\|PubMed:17396150, ECO:0000269\|PubMed:18055453, ECO:0000269\|PubMed:18172500, ECO:0000269\|PubMed:19344625, ECO:0000269\|PubMed:19661379, ECO:0000269\|PubMed:19764761, ECO:0000269\|PubMed:20388712, ECO:0000269\|PubMed:21680843, ECO:0000269\|PubMed:22464733, ECO:0000269\|PubMed:22582261, ECO:0000269\|PubMed:23230272, ECO:0000269\|PubMed:24906880, ECO:0000269\|PubMed:25043379, ECO:0000269\|PubMed:26344098, ECO:0000269\|PubMed:26626479, ECO:0000269\|PubMed:26626480, ECO:0000269\|PubMed:27067600, ECO:0000269\|PubMed:27256882, ECO:0000269\|PubMed:27257257, ECO:0000269\|PubMed:27471034, ECO:0000269\|PubMed:28190768, ECO:0000269\|PubMed:29954836, ECO:0000269\|PubMed:30104678, ECO:0000269\|PubMed:30257210, ECO:0000269\|PubMed:30356214, ECO:0000269\|PubMed:31796734, ECO:0000269\|PubMed:32028527, ECO:0000269\|PubMed:32241924, ECO:0000269\|PubMed:32315358, ECO:0000269\|PubMed:32358582, ECO:0000269\|PubMed:32844745, ECO:0000269\|PubMed:33186521, ECO:0000269\|PubMed:33412112, ECO:0000269\|PubMed:33589610, ECO:0000269\|PubMed:33683197, ECO:0000269\|PubMed:34049076, ECO:0000269\|PubMed:34465625, ECO:0000269\|PubMed:34625544, ECO:0000269\|PubMed:34732825, ECO:0000269\|PubMed:34737271, ECO:0000269\|PubMed:34795260, ECO:0000269\|PubMed:34874266, ECO:0000269\|PubMed:35124853, ECO:0000269\|PubMed:35393539, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:7852410, ECO:0000269\|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269\|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269\|PubMed:35104452}.
P12882	MYH1	S1600	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12883	MYH7	S1596	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P12956	XRCC6	S33	ochoa\|psp	X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269\|PubMed:11493912, ECO:0000269\|PubMed:12145306, ECO:0000269\|PubMed:15023334, ECO:0000269\|PubMed:18362350, ECO:0000269\|PubMed:20383123, ECO:0000269\|PubMed:20493174, ECO:0000269\|PubMed:2466842, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:7957065, ECO:0000269\|PubMed:8621488, ECO:0000269\|PubMed:9742108}.
P13533	MYH6	S1598	ochoa	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	Muscle contraction.
P14618	PKM	S77	ochoa	Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)	Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269\|PubMed:15996096, ECO:0000269\|PubMed:1854723, ECO:0000269\|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250\|UniProtKB:P52480, ECO:0000269\|PubMed:17308100, ECO:0000269\|PubMed:18191611, ECO:0000269\|PubMed:18337823, ECO:0000269\|PubMed:20847263, ECO:0000269\|PubMed:21620138, ECO:0000269\|PubMed:22056988, ECO:0000269\|PubMed:22306293, ECO:0000269\|PubMed:22901803, ECO:0000269\|PubMed:24120661, ECO:0000269\|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269\|PubMed:18337823, ECO:0000269\|PubMed:20847263}.
P14618	PKM	S100	ochoa\|psp	Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)	Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269\|PubMed:15996096, ECO:0000269\|PubMed:1854723, ECO:0000269\|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250\|UniProtKB:P52480, ECO:0000269\|PubMed:17308100, ECO:0000269\|PubMed:18191611, ECO:0000269\|PubMed:18337823, ECO:0000269\|PubMed:20847263, ECO:0000269\|PubMed:21620138, ECO:0000269\|PubMed:22056988, ECO:0000269\|PubMed:22306293, ECO:0000269\|PubMed:22901803, ECO:0000269\|PubMed:24120661, ECO:0000269\|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269\|PubMed:18337823, ECO:0000269\|PubMed:20847263}.
P15336	ATF2	S367	psp	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269\|PubMed:10821277, ECO:0000269\|PubMed:15916964, ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:22304920}.
P15924	DSP	S1361	ochoa	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)	Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250\|UniProtKB:F1LMV6}.
P16157	ANK1	S1617	ochoa	Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269\|PubMed:12456646, ECO:0000269\|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269\|PubMed:12527750}.
P16435	POR	S67	ochoa	NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)	This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255\|HAMAP-Rule:MF_03212}.
P17029	ZKSCAN1	S287	ochoa	Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18)	May be involved in transcriptional regulation.
P20309	CHRM3	S292	ochoa	Muscarinic acetylcholine receptor M3	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269\|PubMed:7565628}.
P20700	LMNB1	S232	ochoa	Lamin-B1	Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269\|PubMed:28716252, ECO:0000269\|PubMed:32910914}.
P21333	FLNA	S1411	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21796	VDAC1	S102	ochoa\|psp	Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1)	Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250\|UniProtKB:Q60932, ECO:0000269\|PubMed:10661876, ECO:0000269\|PubMed:11845315, ECO:0000269\|PubMed:15033708, ECO:0000269\|PubMed:18755977, ECO:0000269\|PubMed:20230784, ECO:0000269\|PubMed:25296756, ECO:0000269\|PubMed:30061676, ECO:0000269\|PubMed:31015432, ECO:0000269\|PubMed:32047033, ECO:0000269\|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269\|PubMed:38065946}.
P26639	TARS1	S110	ochoa	Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250\|UniProtKB:Q9D0R2, ECO:0000269\|PubMed:25824639, ECO:0000269\|PubMed:31374204}.
P26639	TARS1	S534	ochoa	Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250\|UniProtKB:Q9D0R2, ECO:0000269\|PubMed:25824639, ECO:0000269\|PubMed:31374204}.
P27695	APEX1	S54	ochoa	DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]	Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250\|UniProtKB:P28352, ECO:0000269\|PubMed:10023679, ECO:0000269\|PubMed:11118054, ECO:0000269\|PubMed:11452037, ECO:0000269\|PubMed:11809897, ECO:0000269\|PubMed:11832948, ECO:0000269\|PubMed:12524539, ECO:0000269\|PubMed:14633989, ECO:0000269\|PubMed:15380100, ECO:0000269\|PubMed:15831793, ECO:0000269\|PubMed:16617147, ECO:0000269\|PubMed:1719477, ECO:0000269\|PubMed:18179823, ECO:0000269\|PubMed:18439621, ECO:0000269\|PubMed:18579163, ECO:0000269\|PubMed:18809583, ECO:0000269\|PubMed:19123919, ECO:0000269\|PubMed:19188445, ECO:0000269\|PubMed:19401441, ECO:0000269\|PubMed:19934257, ECO:0000269\|PubMed:20699270, ECO:0000269\|PubMed:21496894, ECO:0000269\|PubMed:21762700, ECO:0000269\|PubMed:24079850, ECO:0000269\|PubMed:7516064, ECO:0000269\|PubMed:8355688, ECO:0000269\|PubMed:8621488, ECO:0000269\|PubMed:8932375, ECO:0000269\|PubMed:8995436, ECO:0000269\|PubMed:9108029, ECO:0000269\|PubMed:9207062, ECO:0000269\|PubMed:9560228, ECO:0000269\|PubMed:9804799}.
P28715	ERCC5	S562	ochoa	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein)	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269\|PubMed:16246722, ECO:0000269\|PubMed:26833090, ECO:0000269\|PubMed:31253769, ECO:0000269\|PubMed:32522879, ECO:0000269\|PubMed:32821917, ECO:0000269\|PubMed:7651464, ECO:0000269\|PubMed:8078765, ECO:0000269\|PubMed:8090225, ECO:0000269\|PubMed:8206890, ECO:0000269\|PubMed:9927729}.
P28715	ERCC5	S697	ochoa	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein)	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269\|PubMed:16246722, ECO:0000269\|PubMed:26833090, ECO:0000269\|PubMed:31253769, ECO:0000269\|PubMed:32522879, ECO:0000269\|PubMed:32821917, ECO:0000269\|PubMed:7651464, ECO:0000269\|PubMed:8078765, ECO:0000269\|PubMed:8090225, ECO:0000269\|PubMed:8206890, ECO:0000269\|PubMed:9927729}.
P30622	CLIP1	S973	ochoa	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269\|PubMed:12433698, ECO:0000269\|PubMed:17563362, ECO:0000269\|PubMed:17889670}.
P35221	CTNNA1	S44	ochoa	Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)	Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250\|UniProtKB:P26231, ECO:0000269\|PubMed:25653389}.
P36915	GNL1	S344	ochoa	Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1)	Possible regulatory or functional link with the histocompatibility cluster.
P37275	ZEB1	S1018	ochoa	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250\|UniProtKB:Q64318, ECO:0000269\|PubMed:19935649, ECO:0000269\|PubMed:20175752, ECO:0000269\|PubMed:20418909}.
P40926	MDH2	S250	ochoa	Malate dehydrogenase, mitochondrial (EC 1.1.1.37)	None
P41214	EIF2D	S239	ochoa	Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin)	Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269\|PubMed:20566627, ECO:0000269\|PubMed:20713520}.
P42684	ABL2	Y568	ochoa	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250\|UniProtKB:Q4JIM5, ECO:0000269\|PubMed:15735735, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:18945674}.
P42684	ABL2	S655	ochoa	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250\|UniProtKB:Q4JIM5, ECO:0000269\|PubMed:15735735, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:18945674}.
P43487	RANBP1	S60	ochoa\|psp	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250\|UniProtKB:P34022, ECO:0000269\|PubMed:17671426, ECO:0000269\|PubMed:20485264, ECO:0000269\|PubMed:7616957, ECO:0000269\|PubMed:7882974}.
P46013	MKI67	S2629	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46100	ATRX	S1527	ochoa	Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269\|PubMed:12953102, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:21029860, ECO:0000269\|PubMed:22391447, ECO:0000269\|PubMed:22829774, ECO:0000269\|PubMed:24500201, ECO:0000269\|PubMed:27029610}.
P46821	MAP1B	S970	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46821	MAP1B	S1406	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46821	MAP1B	S1666	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P48444	ARCN1	S220	ochoa	Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)	Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
P48681	NES	S1442	ochoa	Nestin	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P48775	TDO2	S266	ochoa	Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255\|HAMAP-Rule:MF_03020, ECO:0000269\|PubMed:25066423, ECO:0000269\|PubMed:27762317, ECO:0000269\|PubMed:28285122}.
P49321	NASP	S191	ochoa	Nuclear autoantigenic sperm protein (NASP)	Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250\|UniProtKB:Q99MD9, ECO:0000269\|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269\|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269\|PubMed:22195965}.
P49327	FASN	S1028	psp	Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269\|PubMed:16215233, ECO:0000269\|PubMed:16969344, ECO:0000269\|PubMed:26851298, ECO:0000269\|PubMed:7567999, ECO:0000269\|PubMed:8962082, ECO:0000269\|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269\|PubMed:34320401}.
P51114	FXR1	S432	ochoa	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250\|UniProtKB:Q61584, ECO:0000269\|PubMed:17382880, ECO:0000269\|PubMed:20417602, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:30067974, ECO:0000269\|PubMed:30770808, ECO:0000269\|PubMed:32706158, ECO:0000269\|PubMed:34731628, ECO:0000269\|PubMed:35989368, ECO:0000269\|PubMed:36306353, ECO:0000269\|PubMed:39106863}.
P51153	RAB13	S111	ochoa\|psp	Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein)	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269\|PubMed:12058051, ECO:0000269\|PubMed:15096524, ECO:0000269\|PubMed:15528189, ECO:0000269\|PubMed:16525024, ECO:0000269\|PubMed:18779367, ECO:0000269\|PubMed:20008558, ECO:0000269\|PubMed:35343654}.
P51532	SMARCA4	S1417	ochoa\|psp	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)	ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250\|UniProtKB:Q3TKT4, ECO:0000250\|UniProtKB:Q8K1P7, ECO:0000269\|PubMed:15075294, ECO:0000269\|PubMed:19571879, ECO:0000269\|PubMed:20418909, ECO:0000269\|PubMed:29374058, ECO:0000269\|PubMed:30339381, ECO:0000269\|PubMed:32459350, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
P51825	AFF1	S83	ochoa	AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)	None
P51957	NEK4	S563	ochoa	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250\|UniProtKB:Q9Z1J2, ECO:0000269\|PubMed:22851694}.
P52272	HNRNPM	S136	ochoa	Heterogeneous nuclear ribonucleoprotein M (hnRNP M)	Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
P54727	RAD23B	S168	ochoa	UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
P55265	ADAR	S608	ochoa	Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269\|PubMed:12618436, ECO:0000269\|PubMed:15556947, ECO:0000269\|PubMed:15858013, ECO:0000269\|PubMed:16120648, ECO:0000269\|PubMed:16475990, ECO:0000269\|PubMed:17079286, ECO:0000269\|PubMed:19605474, ECO:0000269\|PubMed:19651874, ECO:0000269\|PubMed:19710021, ECO:0000269\|PubMed:19908260, ECO:0000269\|PubMed:21289159, ECO:0000269\|PubMed:22278222, ECO:0000269\|PubMed:7565688, ECO:0000269\|PubMed:7972084}.
P55347	PKNOX1	S41	ochoa	Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)	Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250\|UniProtKB:O70477}.
P56645	PER3	S922	ochoa	Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)	Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK\|NPAS2-BMAL1\|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269\|PubMed:17346965, ECO:0000269\|PubMed:19716732, ECO:0000269\|PubMed:24439663, ECO:0000269\|PubMed:24577121, ECO:0000269\|PubMed:26903630}.
P56945	BCAR1	S437	ochoa	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250\|UniProtKB:Q61140, ECO:0000269\|PubMed:12432078, ECO:0000269\|PubMed:12832404, ECO:0000269\|PubMed:17038317}.
P78347	GTF2I	S103	ochoa	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269\|PubMed:10373551, ECO:0000269\|PubMed:11373296, ECO:0000269\|PubMed:16738337}.
P78559	MAP1A	S1626	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P82094	TMF1	S396	ochoa	TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)	Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269\|PubMed:10428808, ECO:0000269\|PubMed:1409643, ECO:0000269\|PubMed:15467733, ECO:0000269\|PubMed:17698061}.
P98170	XIAP	S40	ochoa\|psp	E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238, PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:9230442). Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640). Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:29452636, PubMed:30026309). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967). {ECO:0000269\|PubMed:11257230, ECO:0000269\|PubMed:11257231, ECO:0000269\|PubMed:11447297, ECO:0000269\|PubMed:12121969, ECO:0000269\|PubMed:12620238, ECO:0000269\|PubMed:14685266, ECO:0000269\|PubMed:16352606, ECO:0000269\|PubMed:16916640, ECO:0000269\|PubMed:17560374, ECO:0000269\|PubMed:17967870, ECO:0000269\|PubMed:19473982, ECO:0000269\|PubMed:19667203, ECO:0000269\|PubMed:20154138, ECO:0000269\|PubMed:21145488, ECO:0000269\|PubMed:22103349, ECO:0000269\|PubMed:22304967, ECO:0000269\|PubMed:22607974, ECO:0000269\|PubMed:29020630, ECO:0000269\|PubMed:29452636, ECO:0000269\|PubMed:30026309, ECO:0000269\|PubMed:9230442, ECO:0000303\|PubMed:22095281}.
Q00341	HDLBP	S944	ochoa	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)	Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q00536	CDK16	S86	ochoa\|psp	Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)	Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269\|PubMed:22184064, ECO:0000269\|PubMed:22796189, ECO:0000269\|PubMed:22798068}.
Q00987	MDM2	S188	psp	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:29681526, ECO:0000269\|PubMed:30879903}.
Q01201	RELB	S254	ochoa	Transcription factor RelB (I-Rel)	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269\|PubMed:1732739, ECO:0000269\|PubMed:22565310, ECO:0000269\|PubMed:26385063, ECO:0000269\|PubMed:7925301, ECO:0000269\|PubMed:8441398}.
Q01484	ANK2	S2127	ochoa	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)	Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250\|UniProtKB:Q8C8R3, ECO:0000269\|PubMed:12571597}.
Q01650	SLC7A5	S35	ochoa	Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)	The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine (PubMed:10049700, PubMed:10574970, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591, PubMed:9751058). The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). {ECO:0000250\|UniProtKB:Q63016, ECO:0000250\|UniProtKB:Q9Z127, ECO:0000269\|PubMed:10049700, ECO:0000269\|PubMed:10574970, ECO:0000269\|PubMed:11557028, ECO:0000269\|PubMed:11564694, ECO:0000269\|PubMed:12117417, ECO:0000269\|PubMed:12225859, ECO:0000269\|PubMed:15769744, ECO:0000269\|PubMed:18262359, ECO:0000269\|PubMed:25998567, ECO:0000269\|PubMed:30867591, ECO:0000269\|PubMed:9751058, ECO:0000305\|PubMed:18262359}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269\|PubMed:30341327}.
Q01850	CDR2	S210	ochoa	Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen)	None
Q02641	CACNB1	S417	ochoa	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)	Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250\|UniProtKB:P19517, ECO:0000269\|PubMed:1309651, ECO:0000269\|PubMed:15615847, ECO:0000269\|PubMed:8107964}.
Q03164	KMT2A	S897	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q04759	PRKCQ	S685	ochoa	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269\|PubMed:11342610, ECO:0000269\|PubMed:14988727, ECO:0000269\|PubMed:15364919, ECO:0000269\|PubMed:16252004, ECO:0000269\|PubMed:16356855, ECO:0000269\|PubMed:16709830, ECO:0000269\|PubMed:19549985, ECO:0000269\|PubMed:21964608, ECO:0000269\|PubMed:23509302, ECO:0000269\|PubMed:36040231, ECO:0000269\|PubMed:8657160}.
Q05655	PRKCD	S654	ochoa	Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250\|UniProtKB:P28867, ECO:0000269\|PubMed:11748588, ECO:0000269\|PubMed:11877440, ECO:0000269\|PubMed:12649167, ECO:0000269\|PubMed:15774464, ECO:0000269\|PubMed:16940418, ECO:0000269\|PubMed:17303575, ECO:0000269\|PubMed:18285462, ECO:0000269\|PubMed:19587372, ECO:0000269\|PubMed:19801500, ECO:0000303\|PubMed:21406692, ECO:0000303\|PubMed:21810427}.
Q07021	C1QBP	S210	ochoa	Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)	Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250\|UniProtKB:O35658, ECO:0000269\|PubMed:10022843, ECO:0000269\|PubMed:10479529, ECO:0000269\|PubMed:10722602, ECO:0000269\|PubMed:11086025, ECO:0000269\|PubMed:11859136, ECO:0000269\|PubMed:15243141, ECO:0000269\|PubMed:16140380, ECO:0000269\|PubMed:16177118, ECO:0000269\|PubMed:17486078, ECO:0000269\|PubMed:17881511, ECO:0000269\|PubMed:18676636, ECO:0000269\|PubMed:19004836, ECO:0000269\|PubMed:19164550, ECO:0000269\|PubMed:20810993, ECO:0000269\|PubMed:21536856, ECO:0000269\|PubMed:21544310, ECO:0000269\|PubMed:22700724, ECO:0000269\|PubMed:28942965, ECO:0000269\|PubMed:31353207, ECO:0000269\|PubMed:39019044, ECO:0000269\|PubMed:8195709, ECO:0000269\|PubMed:8662673, ECO:0000269\|PubMed:8710908, ECO:0000269\|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269\|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269\|PubMed:10722602, ECO:0000269\|PubMed:10747014, ECO:0000269\|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269\|PubMed:12034482}.
Q07157	TJP1	S1139	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q12830	BPTF	S572	ochoa	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269\|PubMed:10575013, ECO:0000269\|PubMed:14609955, ECO:0000269\|PubMed:16728976, ECO:0000269\|PubMed:16728978, ECO:0000269\|PubMed:18042461, ECO:0000269\|PubMed:28801535}.
Q12849	GRSF1	S244	ochoa	G-rich sequence factor 1 (GRSF-1)	Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269\|PubMed:23473033, ECO:0000269\|PubMed:23473034, ECO:0000269\|PubMed:29967381}.
Q12873	CHD3	S1645	ochoa	Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:17626165, ECO:0000269\|PubMed:27068747, ECO:0000269\|PubMed:28977666, ECO:0000269\|PubMed:30397230, ECO:0000269\|PubMed:9804427}.
Q12888	TP53BP1	S1778	psp	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q12955	ANK3	S2009	ochoa	Ankyrin-3 (ANK-3) (Ankyrin-G)	Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250\|UniProtKB:G5E8K5, ECO:0000250\|UniProtKB:O70511, ECO:0000269\|PubMed:23903368, ECO:0000269\|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305\|PubMed:17974005}.
Q13029	PRDM2	S427	ochoa	PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)	S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269\|PubMed:14633678}.
Q13129	RLF	S1272	ochoa	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)	May be involved in transcriptional regulation.
Q13144	EIF2B5	S540	psp	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269\|PubMed:25858979, ECO:0000269\|PubMed:27023709, ECO:0000269\|PubMed:31048492}.
Q13144	EIF2B5	S544	ochoa\|psp	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269\|PubMed:25858979, ECO:0000269\|PubMed:27023709, ECO:0000269\|PubMed:31048492}.
Q13428	TCOF1	S107	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S111	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13464	ROCK1	S1102	ochoa	Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)	Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250\|UniProtKB:P70335, ECO:0000250\|UniProtKB:Q8MIT6, ECO:0000269\|PubMed:10436159, ECO:0000269\|PubMed:10652353, ECO:0000269\|PubMed:11018042, ECO:0000269\|PubMed:11283607, ECO:0000269\|PubMed:17158456, ECO:0000269\|PubMed:18573880, ECO:0000269\|PubMed:18694941, ECO:0000269\|PubMed:19036714, ECO:0000269\|PubMed:19131646, ECO:0000269\|PubMed:19181962, ECO:0000269\|PubMed:19997641, ECO:0000269\|PubMed:21072057, ECO:0000269\|PubMed:23093407, ECO:0000269\|PubMed:23355470, ECO:0000269\|PubMed:8617235, ECO:0000269\|PubMed:9722579}.
Q13563	PKD2	S801	ochoa\|psp	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250\|UniProtKB:O35245, ECO:0000269\|PubMed:11854751, ECO:0000269\|PubMed:11991947, ECO:0000269\|PubMed:15692563, ECO:0000269\|PubMed:18695040, ECO:0000269\|PubMed:26269590, ECO:0000269\|PubMed:27071085, ECO:0000269\|PubMed:27214281, ECO:0000269\|PubMed:29899465, ECO:0000269\|PubMed:31441214, ECO:0000269\|PubMed:33164752, ECO:0000269\|PubMed:39009345}.
Q13884	SNTB1	S227	ochoa	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Q14005	IL16	S1077	ochoa	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14139	UBE4A	S74	ochoa	Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250\|UniProtKB:E9Q735, ECO:0000250\|UniProtKB:P54860}.
Q14151	SAFB2	S245	ochoa	Scaffold attachment factor B2 (SAF-B2)	Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14152	EIF3A	S1364	psp	Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255\|HAMAP-Rule:MF_03000, ECO:0000269\|PubMed:11169732, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269\|PubMed:23766293, ECO:0000269\|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
Q14157	UBAP2L	S265	ochoa	Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L)	Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250\|UniProtKB:Q80X50, ECO:0000269\|PubMed:29395067, ECO:0000269\|PubMed:35633597}.
Q14566	MCM6	S689	ochoa	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269\|PubMed:16899510, ECO:0000269\|PubMed:32453425, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:34700328, ECO:0000269\|PubMed:35585232, ECO:0000269\|PubMed:9305914}.
Q14586	ZNF267	S159	ochoa	Zinc finger protein 267 (Zinc finger protein HZF2)	May be involved in transcriptional regulation.
Q14690	PDCD11	S1493	ochoa	Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11)	Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269\|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}.
Q147X3	NAA30	S196	ochoa	N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit)	Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269\|PubMed:19398576, ECO:0000269\|PubMed:37891180}.
Q14978	NOLC1	S582	ochoa	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269\|PubMed:10567578, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:9016786}.
Q15018	ABRAXAS2	S272	ochoa	BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)	Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250\|UniProtKB:Q3TCJ1, ECO:0000269\|PubMed:19214193, ECO:0000269\|PubMed:20032457, ECO:0000269\|PubMed:20656690, ECO:0000269\|PubMed:24075985, ECO:0000269\|PubMed:25283148}.
Q15032	R3HDM1	S302	ochoa	R3H domain-containing protein 1	None
Q15059	BRD3	S681	ochoa	Bromodomain-containing protein 3 (RING3-like protein)	Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:22464331, ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:29567837, ECO:0000269\|PubMed:32895492}.
Q15361	TTF1	S481	ochoa	Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I)	Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250\|UniProtKB:Q62187, ECO:0000269\|PubMed:7597036}.
Q15424	SAFB	S246	ochoa	Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein)	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250\|UniProtKB:D3YXK2, ECO:0000269\|PubMed:12660241, ECO:0000269\|PubMed:9671816}.
Q15459	SF3A1	S508	ochoa	Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:11533230, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:30315277, ECO:0000269\|PubMed:32494006}.
Q15652	JMJD1C	S2047	ochoa	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8)	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.
Q16254	E2F4	S384	psp	Transcription factor E2F4 (E2F-4)	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250\|UniProtKB:Q6DE14, ECO:0000269\|PubMed:7958924, ECO:0000269\|PubMed:7958925}.
Q2NKX8	ERCC6L	S864	ochoa	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)	DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269\|PubMed:17218258, ECO:0000269\|PubMed:23973328, ECO:0000269\|PubMed:28977671}.
Q32MZ4	LRRFIP1	S639	ochoa	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)	Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269\|PubMed:10364563, ECO:0000269\|PubMed:14522076, ECO:0000269\|PubMed:16199883, ECO:0000269\|PubMed:19265123, ECO:0000269\|PubMed:9705290}.
Q32MZ4	LRRFIP1	S735	ochoa	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)	Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269\|PubMed:10364563, ECO:0000269\|PubMed:14522076, ECO:0000269\|PubMed:16199883, ECO:0000269\|PubMed:19265123, ECO:0000269\|PubMed:9705290}.
Q49MG5	MAP9	S289	ochoa\|psp	Microtubule-associated protein 9 (Aster-associated protein)	Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269\|PubMed:16049101}.
Q4LE39	ARID4B	S1256	ochoa	AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)	Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250\|UniProtKB:A2CG63, ECO:0000269\|PubMed:12724404}.
Q53QZ3	ARHGAP15	S243	ochoa	Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269\|PubMed:12650940}.
Q5FWF5	ESCO1	S24	ochoa	N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1)	Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269\|PubMed:14576321, ECO:0000269\|PubMed:15958495, ECO:0000269\|PubMed:18614053, ECO:0000269\|PubMed:19907496, ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161}.
Q5M775	SPECC1	S425	ochoa	Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)	None
Q5SW79	CEP170	S619	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5SWA1	PPP1R15B	S407	ochoa	Protein phosphatase 1 regulatory subunit 15B	Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269\|PubMed:26159176, ECO:0000269\|PubMed:26307080}.
Q5T1M5	FKBP15	S960	ochoa	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269\|PubMed:19121306}.
Q5T1M5	FKBP15	S964	ochoa	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269\|PubMed:19121306}.
Q5T200	ZC3H13	S1409	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5T8P6	RBM26	S127	ochoa	RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)	May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269\|PubMed:31950173}.
Q5T8P6	RBM26	S131	ochoa	RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)	May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269\|PubMed:31950173}.
Q5TB80	CEP162	S144	ochoa	Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)	Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269\|PubMed:23644468}.
Q5TC82	RC3H1	S808	ochoa	Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)	Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250\|UniProtKB:Q4VGL6, ECO:0000269\|PubMed:25026078, ECO:0000269\|PubMed:25504471, ECO:0000269\|PubMed:25697406, ECO:0000269\|PubMed:26489670, ECO:0000269\|PubMed:31636267}.
Q5UIP0	RIF1	S1576	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q5UIP0	RIF1	S1926	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q63HK5	TSHZ3	S644	ochoa	Teashirt homolog 3 (Zinc finger protein 537)	Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250\|UniProtKB:Q8CGV9, ECO:0000269\|PubMed:19343227}.
Q641Q2	WASHC2A	S284	ochoa	WASH complex subunit 2A	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269\|PubMed:25355947, ECO:0000269\|PubMed:28892079}.
Q6KC79	NIPBL	S2652	ochoa	Nipped-B-like protein (Delangin) (SCC2 homolog)	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250\|UniProtKB:Q6KCD5, ECO:0000269\|PubMed:22628566, ECO:0000269\|PubMed:28167679, ECO:0000269\|PubMed:28914604}.
Q6P1L5	FAM117B	S276	ochoa	Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein)	None
Q6P4F7	ARHGAP11A	S291	ochoa	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269\|PubMed:27957544}.
Q6PGQ7	BORA	S374	ochoa	Protein aurora borealis (HsBora)	Required for the activation of AURKA at the onset of mitosis. {ECO:0000269\|PubMed:16890155}.
Q6PJP8	DCLRE1A	S643	ochoa	DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)	May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269\|PubMed:15542852}.
Q6VMQ6	ATF7IP	S486	ochoa	Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:14536086, ECO:0000269\|PubMed:19106100, ECO:0000269\|PubMed:27732843}.
Q6WCQ1	MPRIP	S800	ochoa	Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)	Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250\|UniProtKB:P97434, ECO:0000269\|PubMed:15545284, ECO:0000269\|PubMed:16257966}.
Q6Y2X3	DNAJC14	S188	ochoa	DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3)	Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}.
Q6Y2X3	DNAJC14	S516	ochoa	DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3)	Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}.
Q717R9	CYS1	S128	ochoa	Cystin-1 (Cilia-associated protein)	None
Q71F23	CENPU	S158	ochoa	Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269\|PubMed:12941884, ECO:0000269\|PubMed:16716197, ECO:0000269\|PubMed:17081991}.
Q7LBC6	KDM3B	S1253	ochoa	Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B)	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269\|PubMed:16603237}.
Q7Z3F1	GPR155	S841	ochoa	Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22)	Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:36007018, PubMed:39358511). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (PubMed:39358511). {ECO:0000269\|PubMed:36007018, ECO:0000269\|PubMed:39358511}.
Q7Z4H7	HAUS6	S519	ochoa	HAUS augmin-like complex subunit 6	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.
Q86TI0	TBC1D1	S649	ochoa	TBC1 domain family member 1	May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86U86	PBRM1	S178	ochoa	Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269\|PubMed:21248752, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
Q86UR5	RIMS1	S1331	ochoa	Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)	Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250\|UniProtKB:Q99NE5, ECO:0000269\|PubMed:23999003}.
Q86UV5	USP48	S910	ochoa	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)	Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability (PubMed:34445214). In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death (PubMed:35913642). Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms (PubMed:36293380). Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination (PubMed:36607699). {ECO:0000269\|PubMed:16214042, ECO:0000269\|PubMed:34059922, ECO:0000269\|PubMed:34445214, ECO:0000269\|PubMed:35913642, ECO:0000269\|PubMed:36293380, ECO:0000269\|PubMed:36607699}.
Q86V15	CASZ1	S151	ochoa	Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)	Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269\|PubMed:23639441, ECO:0000269\|PubMed:27693370}.
Q86W50	METTL16	S484	ochoa	RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346)	RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269\|PubMed:27872311, ECO:0000269\|PubMed:28525753, ECO:0000269\|PubMed:29051200, ECO:0000269\|PubMed:30197297, ECO:0000269\|PubMed:30197299, ECO:0000269\|PubMed:32266935, ECO:0000269\|PubMed:33428944}.
Q86WN1	FCHSD1	S435	ochoa	F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)	Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250\|UniProtKB:Q6PFY1}.
Q86X27	RALGPS2	S422	ochoa	Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)	Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q86XP1	DGKH	S608	ochoa	Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)	Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269\|PubMed:12810723, ECO:0000269\|PubMed:19710016, ECO:0000269\|PubMed:23949095, ECO:0000305}.
Q86Y26	NUTM1	S1029	psp	NUT family member 1 (Nuclear protein in testis)	Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269\|PubMed:30447097}.
Q8IWZ8	SUGP1	S409	ochoa	SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)	Plays a role in pre-mRNA splicing.
Q8N108	MIER1	S130	ochoa	Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)	Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269\|PubMed:12482978}.
Q8N157	AHI1	S1002	ochoa	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)	Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250\|UniProtKB:Q8K3E5, ECO:0000269\|PubMed:21623382}.
Q8N163	CCAR2	S611	ochoa	Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)	Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269\|PubMed:18235501, ECO:0000269\|PubMed:18235502, ECO:0000269\|PubMed:19131338, ECO:0000269\|PubMed:19218236, ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:20160719, ECO:0000269\|PubMed:21030595, ECO:0000269\|PubMed:22446626, ECO:0000269\|PubMed:23352644, ECO:0000269\|PubMed:23398316, ECO:0000269\|PubMed:24415752, ECO:0000269\|PubMed:24824780, ECO:0000269\|PubMed:25361978, ECO:0000269\|PubMed:25661920, ECO:0000269\|PubMed:25732823}.
Q8N392	ARHGAP18	S263	ochoa	Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)	Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269\|PubMed:21865595, ECO:0000269\|PubMed:25778702}.
Q8N4C6	NIN	S172	ochoa	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)	Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269\|PubMed:11956314, ECO:0000269\|PubMed:15190203, ECO:0000269\|PubMed:23386061}.
Q8NCF5	NFATC2IP	S88	ochoa	NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)	In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
Q8NCF5	NFATC2IP	S170	ochoa	NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)	In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
Q8NEY1	NAV1	S935	ochoa	Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)	May be involved in neuronal migration. {ECO:0000250}.
Q8NF91	SYNE1	S5881	ochoa	Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250\|UniProtKB:Q6ZWR6, ECO:0000269\|PubMed:11792814, ECO:0000269\|PubMed:18396275}.
Q8TBF4	ZCRB1	S168	ochoa	Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)	None
Q8TC90	CCER1	S226	ochoa	Coiled-coil domain-containing glutamate-rich protein 1	Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation. {ECO:0000250\|UniProtKB:Q9CQL2}.
Q8TD08	MAPK15	S331	psp	Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)	Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250\|UniProtKB:Q80Y86, ECO:0000250\|UniProtKB:Q9Z2A6, ECO:0000269\|PubMed:11875070, ECO:0000269\|PubMed:16484222, ECO:0000269\|PubMed:19166846, ECO:0000269\|PubMed:20638370, ECO:0000269\|PubMed:20733054, ECO:0000269\|PubMed:21190936, ECO:0000269\|PubMed:21847093, ECO:0000269\|PubMed:22948227, ECO:0000269\|PubMed:24618899, ECO:0000269\|PubMed:26595526, ECO:0000269\|PubMed:28842414, ECO:0000269\|PubMed:29021280}.
Q8TD26	CHD6	S1360	ochoa	Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)	ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269\|PubMed:16314513, ECO:0000269\|PubMed:17027977, ECO:0000269\|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269\|PubMed:20631145, ECO:0000269\|PubMed:21899694, ECO:0000269\|PubMed:23408615}.
Q8TE99	PXYLP1	S383	ochoa	2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)	Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269\|PubMed:24425863}.
Q8TEW0	PARD3	S964	ochoa	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250\|UniProtKB:Q99NH2, ECO:0000250\|UniProtKB:Q9Z340, ECO:0000269\|PubMed:10934474, ECO:0000269\|PubMed:10954424, ECO:0000269\|PubMed:19812038, ECO:0000269\|PubMed:27925688}.
Q8TEW0	PARD3	S967	ochoa	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250\|UniProtKB:Q99NH2, ECO:0000250\|UniProtKB:Q9Z340, ECO:0000269\|PubMed:10934474, ECO:0000269\|PubMed:10954424, ECO:0000269\|PubMed:19812038, ECO:0000269\|PubMed:27925688}.
Q8TF40	FNIP1	S714	ochoa	Folliculin-interacting protein 1	Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250\|UniProtKB:Q68FD7, ECO:0000250\|UniProtKB:Q9P278, ECO:0000269\|PubMed:17028174, ECO:0000269\|PubMed:18663353, ECO:0000269\|PubMed:24081491, ECO:0000269\|PubMed:25126726, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:30699359, ECO:0000269\|PubMed:32905580, ECO:0000269\|PubMed:37079666}.
Q8WU17	RNF139	S634	ochoa	E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)	E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067). {ECO:0000269\|PubMed:10500182, ECO:0000269\|PubMed:12032852, ECO:0000269\|PubMed:17016439, ECO:0000269\|PubMed:19706601, ECO:0000269\|PubMed:19720873, ECO:0000269\|PubMed:20068067, ECO:0000269\|PubMed:22143767, ECO:0000269\|PubMed:23223569}.
Q8WUR7	C15orf40	S116	ochoa	UPF0235 protein C15orf40	None
Q8WUX9	CHMP7	S232	ochoa	Charged multivesicular body protein 7 (Chromatin-modifying protein 7)	ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269\|PubMed:16856878, ECO:0000269\|PubMed:26040712, ECO:0000269\|PubMed:28242692}.
Q8WVB6	CHTF18	S865	ochoa	Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12)	Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269\|PubMed:12766176, ECO:0000269\|PubMed:12930902, ECO:0000269\|PubMed:17545166, ECO:0000269\|PubMed:20227374}.
Q8WWI1	LMO7	S847	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WWI1	LMO7	S1400	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WXG6	MADD	S801	ochoa	MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)	Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250\|UniProtKB:O08873, ECO:0000250\|UniProtKB:Q80U28, ECO:0000269\|PubMed:11577081, ECO:0000269\|PubMed:18559336, ECO:0000269\|PubMed:20937701, ECO:0000269\|PubMed:32761064, ECO:0000269\|PubMed:9115275}.
Q92541	RTF1	S262	ochoa	RNA polymerase-associated protein RTF1 homolog	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269\|PubMed:19345177, ECO:0000269\|PubMed:20178742}.
Q92541	RTF1	S561	ochoa	RNA polymerase-associated protein RTF1 homolog	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269\|PubMed:19345177, ECO:0000269\|PubMed:20178742}.
Q92766	RREB1	S1479	ochoa	Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)	Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250\|UniProtKB:Q3UH06, ECO:0000269\|PubMed:10390538, ECO:0000269\|PubMed:12482979, ECO:0000269\|PubMed:15067362, ECO:0000269\|PubMed:17550981, ECO:0000269\|PubMed:8816445, ECO:0000269\|PubMed:9305772}.
Q92794	KAT6A	S1090	ochoa	Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)	Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269\|PubMed:11742995, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:12771199, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:17925393, ECO:0000269\|PubMed:23431171}.
Q93075	TATDN2	S299	ochoa	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269\|PubMed:37953292}.
Q93075	TATDN2	S453	ochoa	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269\|PubMed:37953292}.
Q969G3	SMARCE1	S136	ochoa	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250\|UniProtKB:O54941, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
Q969K3	RNF34	S254	ochoa	E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269\|PubMed:12118383, ECO:0000269\|PubMed:15069192, ECO:0000269\|PubMed:15897238, ECO:0000269\|PubMed:17121812, ECO:0000269\|PubMed:22064484, ECO:0000269\|PubMed:25012219, ECO:0000269\|Ref.13, ECO:0000303\|PubMed:18382127}.
Q969R5	L3MBTL2	S67	ochoa	Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269\|PubMed:19233876}.
Q96D09	GPRASP2	S550	ochoa	G-protein coupled receptor-associated sorting protein 2 (GASP-2)	May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269\|PubMed:15086532}.
Q96D46	NMD3	S462	ochoa	60S ribosomal export protein NMD3 (hNMD3)	Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269\|PubMed:12724356, ECO:0000269\|PubMed:12773398}.
Q96FF9	CDCA5	S114	ochoa	Sororin (Cell division cycle-associated protein 5) (p35)	Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269\|PubMed:15837422, ECO:0000269\|PubMed:17349791, ECO:0000269\|PubMed:21111234}.
Q96GX5	MASTL	S598	ochoa	Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269\|PubMed:12890928, ECO:0000269\|PubMed:19680222, ECO:0000269\|PubMed:19793917, ECO:0000269\|PubMed:20538976, ECO:0000269\|PubMed:20818157, ECO:0000269\|PubMed:38123684}.
Q96GX5	MASTL	S619	ochoa	Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269\|PubMed:12890928, ECO:0000269\|PubMed:19680222, ECO:0000269\|PubMed:19793917, ECO:0000269\|PubMed:20538976, ECO:0000269\|PubMed:20818157, ECO:0000269\|PubMed:38123684}.
Q96JE7	SEC16B	S167	ochoa	Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)	Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269\|PubMed:17192411, ECO:0000269\|PubMed:21768384, ECO:0000303\|PubMed:22355596}.
Q96JP5	ZFP91	S146	ochoa	E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)	Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269\|PubMed:12738986, ECO:0000269\|PubMed:20682767}.
Q96KQ7	EHMT2	S1084	ochoa	Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250\|UniProtKB:Q9Z148, ECO:0000269\|PubMed:11316813, ECO:0000269\|PubMed:18438403, ECO:0000269\|PubMed:20084102, ECO:0000269\|PubMed:20118233, ECO:0000269\|PubMed:22387026, ECO:0000269\|PubMed:8457211}.
Q96QT4	TRPM7	S1193	psp	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]	Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250\|UniProtKB:Q923J1, ECO:0000269\|PubMed:11385574, ECO:0000269\|PubMed:12887921, ECO:0000269\|PubMed:15485879, ECO:0000269\|PubMed:18365021, ECO:0000269\|PubMed:18394644, ECO:0000269\|PubMed:24316671, ECO:0000269\|PubMed:35561741, ECO:0000269\|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250\|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250\|UniProtKB:Q923J1}.
Q96RL1	UIMC1	S195	ochoa	BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)	Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269\|PubMed:12080054, ECO:0000269\|PubMed:17525340, ECO:0000269\|PubMed:17525341, ECO:0000269\|PubMed:17525342, ECO:0000269\|PubMed:17621610, ECO:0000269\|PubMed:17643121, ECO:0000269\|PubMed:19015238, ECO:0000269\|PubMed:19202061, ECO:0000269\|PubMed:19261748, ECO:0000269\|PubMed:19328070, ECO:0000269\|PubMed:24627472, ECO:0000269\|Ref.38}.
Q96RS0	TGS1	S154	ochoa	Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269\|PubMed:11517327, ECO:0000269\|PubMed:11912212, ECO:0000269\|PubMed:16687569, ECO:0000269\|PubMed:18775984}.
Q96RU2	USP28	S712	ochoa	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)	Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269\|PubMed:16901786, ECO:0000269\|PubMed:17558397, ECO:0000269\|PubMed:17873522, ECO:0000269\|PubMed:18662541, ECO:0000269\|PubMed:24623306}.
Q96S38	RPS6KC1	S667	ochoa	Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein)	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269\|PubMed:12077123, ECO:0000269\|PubMed:15750338}.
Q96SB4	SRPK1	S309	ochoa\|psp	SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269\|PubMed:10049757, ECO:0000269\|PubMed:10390541, ECO:0000269\|PubMed:11509566, ECO:0000269\|PubMed:12134018, ECO:0000269\|PubMed:14555757, ECO:0000269\|PubMed:15034300, ECO:0000269\|PubMed:16122776, ECO:0000269\|PubMed:16209947, ECO:0000269\|PubMed:18155240, ECO:0000269\|PubMed:18687337, ECO:0000269\|PubMed:19240134, ECO:0000269\|PubMed:19477182, ECO:0000269\|PubMed:19886675, ECO:0000269\|PubMed:20708644, ECO:0000269\|PubMed:8208298, ECO:0000269\|PubMed:9237760}.
Q96ST8	CEP89	S188	ochoa	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269\|PubMed:23348840, ECO:0000269\|PubMed:23575228}.
Q96T88	UHRF1	S393	ochoa	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269\|PubMed:10646863, ECO:0000269\|PubMed:15009091, ECO:0000269\|PubMed:15361834, ECO:0000269\|PubMed:17673620, ECO:0000269\|PubMed:17967883, ECO:0000269\|PubMed:19056828, ECO:0000269\|PubMed:21745816, ECO:0000269\|PubMed:21777816, ECO:0000269\|PubMed:22945642, ECO:0000269\|PubMed:30335751, ECO:0000269\|PubMed:37728657}.
Q99081	TCF12	S535	ochoa	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250\|UniProtKB:Q61286, ECO:0000269\|PubMed:32620954}.
Q99418	CYTH2	S56	ochoa	Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)	Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250\|UniProtKB:P63034, ECO:0000269\|PubMed:17398095}.
Q99590	SCAF11	S1058	ochoa	Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)	Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269\|PubMed:9447963}.
Q99767	APBA2	S238	psp	Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2)	Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Q9BRK5	SDF4	S209	ochoa	45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4)	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
Q9BRR9	ARHGAP9	S499	ochoa	Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269\|PubMed:11396949}.
Q9BSQ5	CCM2	S384	ochoa	Cerebral cavernous malformations 2 protein (Malcavernin)	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BUA3	SPINDOC	S148	ochoa	Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC)	Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269\|PubMed:33574238, ECO:0000269\|PubMed:34737271}.
Q9BUB5	MKNK1	S437	ochoa	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269\|PubMed:11463832, ECO:0000269\|PubMed:15350534, ECO:0000269\|PubMed:9155018, ECO:0000269\|PubMed:9878069}.
Q9BW71	HIRIP3	S500	ochoa	HIRA-interacting protein 3	Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269\|PubMed:38334665, ECO:0000269\|PubMed:9710638}.
Q9BXL5	HEMGN	S123	ochoa	Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein)	Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269\|PubMed:14730214, ECO:0000269\|PubMed:15332117, ECO:0000269\|PubMed:15920494}.
Q9BZV1	UBXN6	S252	ochoa	UBX domain-containing protein 6 (UBX domain-containing protein 1)	May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269\|PubMed:19275885, ECO:0000269\|PubMed:21822278, ECO:0000269\|PubMed:23335559, ECO:0000269\|PubMed:26475856, ECO:0000269\|PubMed:27753622}.
Q9GZZ9	UBA5	S358	ochoa	Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)	E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250\|UniProtKB:Q8VE47, ECO:0000269\|PubMed:15071506, ECO:0000269\|PubMed:18442052, ECO:0000269\|PubMed:20368332, ECO:0000269\|PubMed:25219498, ECO:0000269\|PubMed:26929408, ECO:0000269\|PubMed:27545674, ECO:0000269\|PubMed:27545681, ECO:0000269\|PubMed:27653677, ECO:0000269\|PubMed:29295865, ECO:0000269\|PubMed:30412706, ECO:0000269\|PubMed:30626644, ECO:0000269\|PubMed:32160526, ECO:0000269\|PubMed:34588452, ECO:0000269\|PubMed:35394863}.
Q9H0B6	KLC2	Y434	ochoa	Kinesin light chain 2 (KLC 2)	Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269\|PubMed:22172677, ECO:0000305\|PubMed:22172677}.
Q9H0L4	CSTF2T	S113	ochoa	Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64)	May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}.
Q9H0X9	OSBPL5	S325	ochoa	Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)	Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:21220512, ECO:0000269\|PubMed:23934110, ECO:0000269\|PubMed:26206935}.
Q9H2G2	SLK	S543	ochoa	STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)	Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H3Q1	CDC42EP4	S77	ochoa	Cdc42 effector protein 4 (Binder of Rho GTPases 4)	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Q9H4I2	ZHX3	S708	ochoa	Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)	Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269\|PubMed:12659632, ECO:0000269\|PubMed:21174497}.
Q9H4Z2	ZNF335	S645	ochoa	Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1)	Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269\|PubMed:12215545, ECO:0000269\|PubMed:18180299, ECO:0000269\|PubMed:19131338, ECO:0000269\|PubMed:23178126}.
Q9H501	ESF1	S298	ochoa	ESF1 homolog (ABT1-associated protein)	May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H5N1	RABEP2	S193	ochoa	Rab GTPase-binding effector protein 2 (Rabaptin-5beta)	Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269\|PubMed:27224062, ECO:0000269\|PubMed:29425100, ECO:0000269\|PubMed:9524116}.
Q9H6X2	ANTXR1	S381	ochoa	Anthrax toxin receptor 1 (Tumor endothelial marker 8)	Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478). {ECO:0000269\|PubMed:15777794, ECO:0000269\|PubMed:16762926, ECO:0000269\|PubMed:30241478}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269\|PubMed:11700562, ECO:0000269\|PubMed:12700348, ECO:0000269\|PubMed:16762926, ECO:0000269\|PubMed:20585457}.; FUNCTION: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. {ECO:0000269\|PubMed:33924774}.
Q9H7D0	DOCK5	S1740	ochoa	Dedicator of cytokinesis protein 5	Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250\|UniProtKB:B2RY04, ECO:0000269\|PubMed:19004829}.
Q9H7E2	TDRD3	S80	ochoa	Tudor domain-containing protein 3	Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269\|PubMed:15955813, ECO:0000269\|PubMed:18632687, ECO:0000269\|PubMed:21172665, ECO:0000269\|PubMed:35085371}.
Q9H892	TTC12	S67	ochoa	Tetratricopeptide repeat protein 12 (TPR repeat protein 12)	Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. {ECO:0000269\|PubMed:31978331}.
Q9HC52	CBX8	S191	ochoa	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269\|PubMed:21282530}.
Q9HCM4	EPB41L5	S39	ochoa	Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)	Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269\|PubMed:17920587}.
Q9HD20	ATP13A1	S905	ochoa	Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)	Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269\|PubMed:32973005, ECO:0000269\|PubMed:36264797}.
Q9NQS7	INCENP	S481	ochoa	Inner centromere protein	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250\|UniProtKB:P53352, ECO:0000269\|PubMed:12925766, ECO:0000269\|PubMed:15316025, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:21346195, ECO:0000269\|PubMed:27332895}.
Q9NR45	NANS	S134	ochoa	N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase)	Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269\|PubMed:10749855, ECO:0000269\|PubMed:27213289}.
Q9NR48	ASH1L	S1953	ochoa	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)	Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250\|UniProtKB:Q99MY8, ECO:0000269\|PubMed:21239497}.
Q9NRZ9	HELLS	S119	ochoa	Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)	Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250\|UniProtKB:Q60848}.
Q9NUA8	ZBTB40	S621	ochoa	Zinc finger and BTB domain-containing protein 40	May be involved in transcriptional regulation.
Q9NVH1	DNAJC11	S27	ochoa	DnaJ homolog subfamily C member 11	[Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269\|PubMed:25111180, ECO:0000305}.
Q9NVM9	INTS13	S626	ochoa	Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)	Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269\|PubMed:23097494, ECO:0000269\|PubMed:23904267, ECO:0000269\|PubMed:32647223, ECO:0000269\|PubMed:38570683, ECO:0000269\|PubMed:38823386, ECO:0000269\|PubMed:38906142}.
Q9NVW2	RLIM	S215	psp	E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)	E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269\|PubMed:19164295, ECO:0000269\|PubMed:19945382}.
Q9NWH9	SLTM	S209	ochoa	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NWQ4	GPATCH2L	S31	ochoa	G patch domain-containing protein 2-like	None
Q9NYD6	HOXC10	S189	ochoa	Homeobox protein Hox-C10 (Homeobox protein Hox-3I)	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Q9NZJ5	EIF2AK3	S686	ochoa	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2)	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250\|UniProtKB:Q9Z2B5, ECO:0000269\|PubMed:10026192, ECO:0000269\|PubMed:10677345, ECO:0000269\|PubMed:11907036, ECO:0000269\|PubMed:12086964, ECO:0000269\|PubMed:25925385, ECO:0000269\|PubMed:27917829, ECO:0000269\|PubMed:31023583, ECO:0000269\|PubMed:33384352, ECO:0000269\|PubMed:39116259}.
Q9P0K7	RAI14	S512	ochoa	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250\|UniProtKB:Q5U312}.
Q9P2G1	ANKIB1	S1053	ochoa	Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31)	Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9P2H5	USP35	S982	ochoa	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)	Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). {ECO:0000269\|PubMed:25915564, ECO:0000269\|PubMed:26348204, ECO:0000269\|PubMed:29449677, ECO:0000269\|PubMed:34438346, ECO:0000269\|PubMed:37004621}.
Q9P2K5	MYEF2	S571	ochoa	Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)	Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}.
Q9UBB6	NCDN	S448	ochoa	Neurochondrin	Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269\|PubMed:16945926, ECO:0000269\|PubMed:33711248, ECO:0000305\|PubMed:33711248}.
Q9UER7	DAXX	S498	ochoa	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:15364927, ECO:0000269\|PubMed:16845383, ECO:0000269\|PubMed:17081986, ECO:0000269\|PubMed:17942542, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:23222847, ECO:0000269\|PubMed:24200965, ECO:0000269\|PubMed:24530302}.
Q9UHB6	LIMA1	S490	ochoa	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)	Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250\|UniProtKB:Q9ERG0, ECO:0000269\|PubMed:12566430, ECO:0000269\|PubMed:32496561, ECO:0000269\|PubMed:33999101}.
Q9UHR5	SAP30BP	S43	ochoa	SAP30-binding protein (Transcriptional regulator protein HCNGP)	Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250\|UniProtKB:Q02614, ECO:0000269\|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269\|PubMed:21221920}.
Q9UHX1	PUF60	S441	ochoa	Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)	DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269\|PubMed:10606266, ECO:0000269\|PubMed:10882074, ECO:0000269\|PubMed:11239393, ECO:0000269\|PubMed:16452196, ECO:0000269\|PubMed:16628215, ECO:0000269\|PubMed:17579712}.
Q9UIG0	BAZ1B	S57	ochoa	Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)	Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250\|UniProtKB:Q9Z277, ECO:0000269\|PubMed:11980720, ECO:0000269\|PubMed:15543136, ECO:0000269\|PubMed:16603771, ECO:0000269\|PubMed:19092802, ECO:0000269\|PubMed:19234442, ECO:0000269\|PubMed:28801535}.
Q9UIQ6	LNPEP	S85	ochoa	Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]	Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269\|PubMed:11389728, ECO:0000269\|PubMed:11707427, ECO:0000269\|PubMed:1731608}.
Q9UJX4	ANAPC5	S202	ochoa	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
Q9UKJ3	GPATCH8	Y1031	ochoa	G patch domain-containing protein 8	None
Q9UKV3	ACIN1	S453	psp	Apoptotic chromatin condensation inducer in the nucleus (Acinus)	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269\|PubMed:10490026, ECO:0000269\|PubMed:12665594, ECO:0000269\|PubMed:18559500, ECO:0000269\|PubMed:22203037, ECO:0000269\|PubMed:22388736}.
Q9UKX2	MYH2	S1602	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UL26	RAB22A	S175	ochoa	Ras-related protein Rab-22A (Rab-22)	Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). {ECO:0000269\|PubMed:16537905, ECO:0000269\|PubMed:21849477}.
Q9ULU4	ZMYND8	S1090	ochoa	MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)	Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:26655721, ECO:0000269\|PubMed:27477906, ECO:0000269\|PubMed:27732854, ECO:0000269\|PubMed:30134174, ECO:0000269\|PubMed:31965980, ECO:0000269\|PubMed:33323928, ECO:0000269\|PubMed:35916866, ECO:0000269\|PubMed:36064715}.
Q9ULU4	ZMYND8	S1126	ochoa	MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)	Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:26655721, ECO:0000269\|PubMed:27477906, ECO:0000269\|PubMed:27732854, ECO:0000269\|PubMed:30134174, ECO:0000269\|PubMed:31965980, ECO:0000269\|PubMed:33323928, ECO:0000269\|PubMed:35916866, ECO:0000269\|PubMed:36064715}.
Q9ULW0	TPX2	S102	ochoa	Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269\|PubMed:18663142, ECO:0000269\|PubMed:19208764, ECO:0000269\|PubMed:26165940}.
Q9UMZ2	SYNRG	S1044	ochoa	Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)	Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269\|PubMed:15758025, ECO:0000305\|PubMed:12538641}.
Q9UPV7	PHF24	S72	ochoa	PHD finger protein 24	None
Q9UPV9	TRAK1	S535	ochoa	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)	Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250\|UniProtKB:Q960V3, ECO:0000269\|PubMed:18675823, ECO:0000269\|PubMed:24995978}.
Q9UQ35	SRRM2	S1254	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQN3	CHMP2B	S187	ochoa	Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Q9Y294	ASF1A	S172	ochoa	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269\|PubMed:10759893, ECO:0000269\|PubMed:11897662, ECO:0000269\|PubMed:12842904, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527, ECO:0000269\|PubMed:15664198, ECO:0000269\|PubMed:16151251, ECO:0000269\|PubMed:21454524, ECO:0000269\|PubMed:29408485, ECO:0000269\|PubMed:29478807}.
Q9Y2D9	ZNF652	S197	ochoa	Zinc finger protein 652	Functions as a transcriptional repressor. {ECO:0000269\|PubMed:16966434}.
Q9Y2F5	ICE1	S589	ochoa	Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1)	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269\|PubMed:22195968, ECO:0000269\|PubMed:23932780}.
Q9Y2K6	USP20	S263	ochoa	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)	Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269\|PubMed:12056827, ECO:0000269\|PubMed:12865408, ECO:0000269\|PubMed:15776016, ECO:0000269\|PubMed:19424180, ECO:0000269\|PubMed:26839314, ECO:0000269\|PubMed:27801882, ECO:0000269\|PubMed:29487085, ECO:0000269\|PubMed:32354117, ECO:0000269\|PubMed:33792613, ECO:0000269\|PubMed:35063767}.
Q9Y3S1	WNK2	S1262	ochoa	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)	Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250\|UniProtKB:Q9H4A3, ECO:0000269\|PubMed:17667937, ECO:0000269\|PubMed:18593598, ECO:0000269\|PubMed:21733846}.
Q9Y450	HBS1L	S69	ochoa	HBS1-like protein (EC 3.6.5.-) (ERFS)	GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269\|PubMed:21448132, ECO:0000269\|PubMed:23667253, ECO:0000269\|PubMed:27863242, ECO:0000269\|PubMed:32006463}.
Q9Y450	HBS1L	S117	ochoa	HBS1-like protein (EC 3.6.5.-) (ERFS)	GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269\|PubMed:21448132, ECO:0000269\|PubMed:23667253, ECO:0000269\|PubMed:27863242, ECO:0000269\|PubMed:32006463}.
Q9Y490	TLN1	S52	ochoa	Talin-1	High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250\|UniProtKB:P26039}.
Q9Y4E8	USP15	S678	psp	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269\|PubMed:16005295, ECO:0000269\|PubMed:17318178, ECO:0000269\|PubMed:19576224, ECO:0000269\|PubMed:19826004, ECO:0000269\|PubMed:21947082, ECO:0000269\|PubMed:22344298, ECO:0000269\|PubMed:24526689, ECO:0000269\|PubMed:24852371, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269\|PubMed:19553310}.
Q9Y4F5	CEP170B	S425	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y4F5	CEP170B	S597	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y4X5	ARIH1	S517	ochoa	E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)	E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:23707686, PubMed:24076655, PubMed:27565346). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197). {ECO:0000269\|PubMed:14623119, ECO:0000269\|PubMed:15236971, ECO:0000269\|PubMed:17289916, ECO:0000269\|PubMed:21532592, ECO:0000269\|PubMed:23707686, ECO:0000269\|PubMed:24076655, ECO:0000269\|PubMed:25624349, ECO:0000269\|PubMed:27565346, ECO:0000269\|PubMed:29689197}.
Q9Y5K6	CD2AP	S256	ochoa	CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250\|UniProtKB:F1LRS8, ECO:0000250\|UniProtKB:Q9JLQ0, ECO:0000269\|PubMed:10339567, ECO:0000269\|PubMed:15800069, ECO:0000269\|PubMed:22891260}.
Q9Y5T5	USP16	S189	ochoa	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)	Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255\|HAMAP-Rule:MF_03062, ECO:0000269\|PubMed:17914355, ECO:0000269\|PubMed:32129764}.
Q9Y6D5	ARFGEF2	S1514	ochoa	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)	Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269\|PubMed:12051703, ECO:0000269\|PubMed:12571360, ECO:0000269\|PubMed:15385626, ECO:0000269\|PubMed:16477018, ECO:0000269\|PubMed:17276987, ECO:0000269\|PubMed:18625701, ECO:0000269\|PubMed:20360857}.
Q9Y6R1	SLC4A4	S76	ochoa	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)	Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269\|PubMed:10069984, ECO:0000269\|PubMed:11744745, ECO:0000269\|PubMed:12411514, ECO:0000269\|PubMed:12730338, ECO:0000269\|PubMed:12907161, ECO:0000269\|PubMed:14567693, ECO:0000269\|PubMed:15218065, ECO:0000269\|PubMed:15713912, ECO:0000269\|PubMed:15817634, ECO:0000269\|PubMed:15930088, ECO:0000269\|PubMed:16636648, ECO:0000269\|PubMed:16769890, ECO:0000269\|PubMed:17661077, ECO:0000269\|PubMed:23324180, ECO:0000269\|PubMed:23636456, ECO:0000269\|PubMed:29500354, ECO:0000269\|PubMed:9235899, ECO:0000269\|PubMed:9651366}.
Q9Y6U3	SCIN	S602	ochoa	Scinderin (Adseverin)	Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250\|UniProtKB:Q28046, ECO:0000250\|UniProtKB:Q5ZIV9, ECO:0000250\|UniProtKB:Q60604, ECO:0000269\|PubMed:11568009, ECO:0000269\|PubMed:26365202, ECO:0000269\|PubMed:8547642}.
Q9Y6X4	FAM169A	S398	ochoa	Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A)	None
R4GMW8	BIVM-ERCC5	S1016	ochoa	DNA excision repair protein ERCC-5	None
R4GMW8	BIVM-ERCC5	S1151	ochoa	DNA excision repair protein ERCC-5	None
Q9Y2B0	CNPY2	S55	Sugiyama	Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
O00444	PLK4	S640	Sugiyama	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)	Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269\|PubMed:16244668, ECO:0000269\|PubMed:16326102, ECO:0000269\|PubMed:17681131, ECO:0000269\|PubMed:18239451, ECO:0000269\|PubMed:19164942, ECO:0000269\|PubMed:21725316, ECO:0000269\|PubMed:22020124, ECO:0000269\|PubMed:27796307, ECO:0000269\|PubMed:30804208}.
P33240	CSTF2	S44	Sugiyama	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269\|PubMed:32816001, ECO:0000269\|PubMed:9199325}.
P29401	TKT	S473	Sugiyama	Transketolase (TK) (EC 2.2.1.1)	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269\|PubMed:27259054}.
Q86V81	ALYREF	S142	Sugiyama	THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)	Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B (PubMed:17984224). Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex (PubMed:37020021). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:37020021). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224, PubMed:37020021). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation (PubMed:10488337). Involved in transcription elongation and genome stability (PubMed:12438613). {ECO:0000269\|PubMed:10488337, ECO:0000269\|PubMed:11675789, ECO:0000269\|PubMed:11707413, ECO:0000269\|PubMed:11979277, ECO:0000269\|PubMed:12438613, ECO:0000269\|PubMed:15833825, ECO:0000269\|PubMed:15998806, ECO:0000269\|PubMed:17190602, ECO:0000269\|PubMed:17984224, ECO:0000269\|PubMed:18364396, ECO:0000269\|PubMed:19165146, ECO:0000269\|PubMed:22144908, ECO:0000269\|PubMed:22893130, ECO:0000269\|PubMed:23222130, ECO:0000269\|PubMed:25662211, ECO:0000269\|PubMed:28418038, ECO:0000269\|PubMed:37020021}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. {ECO:0000269\|PubMed:12438613, ECO:0000269\|PubMed:18974867}.
Q01970	PLCB3	S1041	Sugiyama	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)	Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250\|UniProtKB:P51432, ECO:0000269\|PubMed:20966218, ECO:0000269\|PubMed:29122926, ECO:0000269\|PubMed:37991948, ECO:0000269\|PubMed:9188725}.
O00571	DDX3X	Y580	Sugiyama	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250\|UniProtKB:Q62167, ECO:0000269\|PubMed:16818630, ECO:0000269\|PubMed:17095540, ECO:0000269\|PubMed:17357160, ECO:0000269\|PubMed:17667941, ECO:0000269\|PubMed:18264132, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:18596238, ECO:0000269\|PubMed:18628297, ECO:0000269\|PubMed:18636090, ECO:0000269\|PubMed:18846110, ECO:0000269\|PubMed:19913487, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20837705, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:21730191, ECO:0000269\|PubMed:21883093, ECO:0000269\|PubMed:22323517, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:23413191, ECO:0000269\|PubMed:23478265, ECO:0000269\|PubMed:27736973, ECO:0000269\|PubMed:27980081, ECO:0000269\|PubMed:28128295, ECO:0000269\|PubMed:28842590, ECO:0000269\|PubMed:29062139, ECO:0000269\|PubMed:29222110, ECO:0000269\|PubMed:30256975, ECO:0000269\|PubMed:30341167, ECO:0000269\|PubMed:31575075, ECO:0000269\|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269\|PubMed:15507209, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269\|PubMed:27105836}.
O15523	DDX3Y	Y578	Sugiyama	ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)	Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250\|UniProtKB:Q62095}.
P08631	HCK	Y127	Sugiyama	Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)	Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269\|PubMed:10092522, ECO:0000269\|PubMed:10779760, ECO:0000269\|PubMed:10973280, ECO:0000269\|PubMed:11741929, ECO:0000269\|PubMed:11896602, ECO:0000269\|PubMed:12411494, ECO:0000269\|PubMed:15010462, ECO:0000269\|PubMed:15952790, ECO:0000269\|PubMed:15998323, ECO:0000269\|PubMed:17310994, ECO:0000269\|PubMed:17535448, ECO:0000269\|PubMed:19114024, ECO:0000269\|PubMed:19903482, ECO:0000269\|PubMed:20452982, ECO:0000269\|PubMed:21338576, ECO:0000269\|PubMed:7535819, ECO:0000269\|PubMed:8132624, ECO:0000269\|PubMed:9406996, ECO:0000269\|PubMed:9407116}.
P55060	CSE1L	S377	Sugiyama	Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)	Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269\|PubMed:9323134}.
Q03112	MECOM	S624	SIGNOR	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)	[Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269\|PubMed:10856240, ECO:0000269\|PubMed:11568182, ECO:0000269\|PubMed:15897867, ECO:0000269\|PubMed:16462766, ECO:0000269\|PubMed:19767769, ECO:0000269\|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250\|UniProtKB:P14404}.
Q00610	CLTC	S886	Sugiyama	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250\|UniProtKB:P49951, ECO:0000269\|PubMed:15858577, ECO:0000269\|PubMed:16968737, ECO:0000269\|PubMed:20639872, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:23532825}.
P49585	PCYT1A	S174	Sugiyama	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A)	Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269\|PubMed:10480912, ECO:0000269\|PubMed:30559292, ECO:0000269\|PubMed:7918629}.
Q00987	MDM2	S192	iPTMNet	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:29681526, ECO:0000269\|PubMed:30879903}.
Q7Z460	CLASP1	S1216	Sugiyama	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269\|PubMed:11290329, ECO:0000269\|PubMed:12837247, ECO:0000269\|PubMed:15631994, ECO:0000269\|PubMed:16866869, ECO:0000269\|PubMed:16914514, ECO:0000269\|PubMed:17543864}.
Q13765	NACA	S191	Sugiyama	Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)	Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269\|PubMed:10982809, ECO:0000269\|PubMed:15784678, ECO:0000269\|PubMed:9877153}.
P51957	NEK4	S526	Sugiyama	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250\|UniProtKB:Q9Z1J2, ECO:0000269\|PubMed:22851694}.
P51957	NEK4	S772	Sugiyama	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250\|UniProtKB:Q9Z1J2, ECO:0000269\|PubMed:22851694}.
Q8NBJ7	SUMF2	S264	Sugiyama	Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)	Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269\|PubMed:12757706, ECO:0000269\|PubMed:15708861, ECO:0000269\|PubMed:15962010}.
Q06481	APLP2	S111	Sugiyama	Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)	May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8307156}.
Q7RTN6	STRADA	S46	Sugiyama	STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96)	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269\|PubMed:12805220, ECO:0000269\|PubMed:14517248, ECO:0000269\|PubMed:19892943}.
Q9GZM8	NDEL1	S95	PSP	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)	Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250\|UniProtKB:Q78PB6, ECO:0000250\|UniProtKB:Q9ERR1, ECO:0000269\|PubMed:12556484, ECO:0000269\|PubMed:14970193, ECO:0000269\|PubMed:16291865, ECO:0000269\|PubMed:17600710, ECO:0000269\|PubMed:34793709}.
Q9NQP4	PFDN4	S103	Sugiyama	Prefoldin subunit 4 (Protein C-1)	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269\|PubMed:9630229}.
Q9H2M9	RAB3GAP2	S455	Sugiyama	Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit)	Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250\|UniProtKB:Q15042, ECO:0000269\|PubMed:24891604, ECO:0000269\|PubMed:26063829, ECO:0000269\|PubMed:9733780}.
Q99558	MAP3K14	S410	Sugiyama	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)	Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269\|PubMed:15084608, ECO:0000269\|PubMed:25406581}.
Q9NR50	EIF2B3	S265	Sugiyama	Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)	Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269\|PubMed:25858979, ECO:0000269\|PubMed:27023709, ECO:0000269\|PubMed:31048492}.
Q9HBH9	MKNK2	S338	Sugiyama	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269\|PubMed:11154262, ECO:0000269\|PubMed:11463832, ECO:0000269\|PubMed:12897141, ECO:0000269\|PubMed:16111636, ECO:0000269\|PubMed:17965020, ECO:0000269\|PubMed:18299328, ECO:0000269\|PubMed:20823271, ECO:0000269\|PubMed:20927323, ECO:0000269\|PubMed:21149447}.
O43815	STRN	S301	Sugiyama	Striatin	Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269\|PubMed:18782753, ECO:0000305\|PubMed:26876214}.
A0A0M3HER8	GOLGA6L10	S444	ochoa	Golgin A6 family like 10	None
A1L170	C1orf226	S196	ochoa	Uncharacterized protein C1orf226	None
A6NEF3	GOLGA6L4	S482	ochoa	Golgin subfamily A member 6-like protein 4	None
A6NEM1	GOLGA6L9	S340	ochoa	Golgin subfamily A member 6-like protein 9	None
A6NI86	GOLGA6L10	S430	ochoa	Golgin subfamily A member 6-like protein 10	None
H0YC42	None	S196	ochoa	Tumor protein D52	None
H0YKK7	GOLGA6L19	S458	ochoa	Putative golgin subfamily A member 6-like protein 19	None
O00257	CBX4	S434	ochoa	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)	E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269\|PubMed:12679040, ECO:0000269\|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250\|UniProtKB:O55187, ECO:0000269\|PubMed:12167701, ECO:0000269\|PubMed:19636380, ECO:0000269\|PubMed:21282530}.
O00422	SAP18	S119	ochoa	Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)	Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. {ECO:0000269\|PubMed:12665594, ECO:0000269\|PubMed:20966198, ECO:0000269\|PubMed:22203037, ECO:0000269\|PubMed:9150135}.
O00461	GOLIM4	Y641	ochoa	Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)	Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269\|PubMed:15331763}.
O00567	NOP56	S511	ochoa	Nucleolar protein 56 (Nucleolar protein 5A)	Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:15574333, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:39570315}.
O15061	SYNM	S777	ochoa	Synemin (Desmuslin)	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269\|PubMed:11353857, ECO:0000269\|PubMed:16777071, ECO:0000269\|PubMed:18028034}.
O60716	CTNND1	S129	ochoa	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269\|PubMed:10207085, ECO:0000269\|PubMed:14610055, ECO:0000269\|PubMed:17344476, ECO:0000269\|PubMed:18343367, ECO:0000269\|PubMed:20371349}.
O60934	NBN	S488	ochoa	Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1)	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269\|PubMed:10888888, ECO:0000269\|PubMed:12419185, ECO:0000269\|PubMed:15064416, ECO:0000269\|PubMed:15616588, ECO:0000269\|PubMed:15790808, ECO:0000269\|PubMed:16622404, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:19759395, ECO:0000269\|PubMed:19804756, ECO:0000269\|PubMed:22464731, ECO:0000269\|PubMed:23115235, ECO:0000269\|PubMed:23762398, ECO:0000269\|PubMed:24534091, ECO:0000269\|PubMed:26438602, ECO:0000269\|PubMed:27814491, ECO:0000269\|PubMed:27889449, ECO:0000269\|PubMed:28216226, ECO:0000269\|PubMed:28867292, ECO:0000269\|PubMed:30787182, ECO:0000269\|PubMed:30952868, ECO:0000269\|PubMed:31537797, ECO:0000269\|PubMed:33836577, ECO:0000269\|PubMed:35076389, ECO:0000269\|PubMed:9705271}.
O75150	RNF40	S528	ochoa	E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269\|PubMed:16307923, ECO:0000269\|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269\|PubMed:37888983}.
O75362	ZNF217	S247	ochoa	Zinc finger protein 217	Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269\|PubMed:16203743, ECO:0000269\|PubMed:16940172, ECO:0000269\|PubMed:17259635, ECO:0000269\|PubMed:18625718}.
O75665	OFD1	S986	ochoa	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250\|UniProtKB:Q80Z25, ECO:0000269\|PubMed:33934390}.
O75717	WDHD1	S1090	ochoa	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)	Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269\|PubMed:19805216, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:35585232}.
O95292	VAPB	S142	ochoa	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269\|PubMed:16891305, ECO:0000269\|PubMed:20940299, ECO:0000269\|PubMed:22131369, ECO:0000269\|PubMed:32344433, ECO:0000269\|PubMed:33124732}.
O95573	ACSL3	S353	ochoa	Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)	Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250\|UniProtKB:Q63151, ECO:0000269\|PubMed:18003621, ECO:0000269\|PubMed:22633490}.
P05771	PRKCB	T314	ochoa	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P0DMV8	HSPA1A	S544	ochoa	Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250\|UniProtKB:P0DMW0, ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:23973223, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27137183, ECO:0000269\|PubMed:27708256, ECO:0000269\|PubMed:28842558, ECO:0000269\|PubMed:9499401, ECO:0000303\|PubMed:24012426, ECO:0000303\|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269\|PubMed:16537599}.
P0DMV9	HSPA1B	S544	ochoa	Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:23973223, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27137183, ECO:0000269\|PubMed:27708256, ECO:0000303\|PubMed:24012426, ECO:0000303\|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269\|PubMed:16537599}.
P10636	MAPT	S673	ochoa\|psp	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
P11171	EPB41	S712	ochoa	Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)	Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269\|PubMed:23870127}.
P20839	IMPDH1	S160	ochoa	Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
P21127	CDK11B	S285	ochoa	Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)	Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269\|PubMed:12501247, ECO:0000269\|PubMed:12624090, ECO:0000269\|PubMed:18216018, ECO:0000269\|PubMed:2217177}.
P22102	GART	S621	ochoa	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]	Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305\|PubMed:12450384, ECO:0000305\|PubMed:12755606, ECO:0000305\|PubMed:20631005, ECO:0000305\|PubMed:2183217}.
P25440	BRD2	S749	ochoa	Bromodomain-containing protein 2 (O27.1.1)	Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269\|PubMed:17148447, ECO:0000269\|PubMed:17848202, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:20048151, ECO:0000269\|PubMed:20709061, ECO:0000269\|PubMed:20871596, ECO:0000269\|PubMed:28262505, ECO:0000269\|PubMed:35410381, ECO:0000269\|PubMed:37731000}.
P27824	CANX	S564	ochoa\|psp	Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)	Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
P28290	ITPRID2	Y657	ochoa	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	None
P29374	ARID4A	S673	ochoa	AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)	DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250\|UniProtKB:F8VPQ2, ECO:0000269\|PubMed:14581478}.
P29375	KDM5A	S1365	ochoa	Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250\|UniProtKB:Q3UXZ9, ECO:0000269\|PubMed:11358960, ECO:0000269\|PubMed:15949438, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17320163, ECO:0000269\|PubMed:18270511, ECO:0000269\|PubMed:19430464, ECO:0000269\|PubMed:27427228}.
P34931	HSPA1L	S546	ochoa	Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269\|PubMed:24270810, ECO:0000303\|PubMed:26865365}.
P34932	HSPA4	S546	ochoa	Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)	None
P39880	CUX1	S1378	ochoa	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]	Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250\|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269\|PubMed:15099520}.
P48681	NES	S1445	ochoa	Nestin	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49006	MARCKSL1	S93	ochoa	MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)	Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250\|UniProtKB:P28667, ECO:0000269\|PubMed:22751924}.
P49321	NASP	S662	ochoa	Nuclear autoantigenic sperm protein (NASP)	Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250\|UniProtKB:Q99MD9, ECO:0000269\|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269\|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269\|PubMed:22195965}.
P49790	NUP153	S619	ochoa	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269\|PubMed:12802065, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269\|PubMed:23523133, ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:31913756}.
P60484	PTEN	S302	ochoa	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)	Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250\|UniProtKB:O08586, ECO:0000250\|UniProtKB:O54857, ECO:0000269\|PubMed:10468583, ECO:0000269\|PubMed:11418101, ECO:0000269\|PubMed:11707428, ECO:0000269\|PubMed:15979280, ECO:0000269\|PubMed:16824732, ECO:0000269\|PubMed:18716620, ECO:0000269\|PubMed:22279049, ECO:0000269\|PubMed:26166433, ECO:0000269\|PubMed:26504226, ECO:0000269\|PubMed:31492966, ECO:0000269\|PubMed:37279284, ECO:0000269\|PubMed:9187108, ECO:0000269\|PubMed:9256433, ECO:0000269\|PubMed:9593664, ECO:0000269\|PubMed:9616126, ECO:0000269\|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269\|PubMed:23744781}.
P78362	SRPK2	S312	ochoa	SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269\|PubMed:12134018, ECO:0000269\|PubMed:16122776, ECO:0000269\|PubMed:18425142, ECO:0000269\|PubMed:18559500, ECO:0000269\|PubMed:19592491, ECO:0000269\|PubMed:21056976, ECO:0000269\|PubMed:21205200, ECO:0000269\|PubMed:28076779, ECO:0000269\|PubMed:9472028}.
Q00536	CDK16	S146	psp	Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)	Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269\|PubMed:22184064, ECO:0000269\|PubMed:22796189, ECO:0000269\|PubMed:22798068}.
Q00987	MDM2	Y281	psp	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:29681526, ECO:0000269\|PubMed:30879903}.
Q01094	E2F1	S403	psp	Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269\|PubMed:10675335, ECO:0000269\|PubMed:12717439, ECO:0000269\|PubMed:17050006, ECO:0000269\|PubMed:17704056, ECO:0000269\|PubMed:18625225, ECO:0000269\|PubMed:20040599, ECO:0000269\|PubMed:20176812, ECO:0000269\|PubMed:28992046, ECO:0000269\|PubMed:8170954}.
Q02952	AKAP12	S381	ochoa	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03001	DST	S2529	ochoa	Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250\|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269\|PubMed:10428034, ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03701	CEBPZ	S41	ochoa	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)	Stimulates transcription from the HSP70 promoter.
Q05682	CALD1	S134	ochoa	Caldesmon (CDM)	Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8227296}.
Q12789	GTF3C1	S1253	ochoa	General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Q12802	AKAP13	S395	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q15057	ACAP2	S384	ochoa	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)	GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269\|PubMed:11062263, ECO:0000269\|PubMed:30905672}.
Q15527	SURF2	S166	ochoa	Surfeit locus protein 2 (Surf-2)	None
Q15545	TAF7	S200	ochoa	Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55)	The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269\|PubMed:10438527, ECO:0000269\|PubMed:33795473}.
Q2M1K9	ZNF423	S47	ochoa	Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein)	Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269\|PubMed:10660046}.
Q4KMZ1	IQCC	S438	ochoa	IQ domain-containing protein C	None
Q53GI3	ZNF394	S258	ochoa	Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14)	May be involved in transcriptional regulation.
Q5T1M5	FKBP15	S1131	ochoa	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269\|PubMed:19121306}.
Q5T200	ZC3H13	S204	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5UIP0	RIF1	S1494	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q68DQ2	CRYBG3	S442	ochoa	Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)	[Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269\|PubMed:25097019}.
Q69YN4	VIRMA	S1464	ochoa	Protein virilizer homolog	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269\|PubMed:24981863, ECO:0000269\|PubMed:29507755}.
Q6IBW4	NCAPH2	S319	psp	Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2)	Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250\|UniProtKB:Q8BSP2, ECO:0000269\|PubMed:14532007}.
Q6JBY9	RCSD1	S219	ochoa	CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1)	Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269\|PubMed:15850461}.
Q6R327	RICTOR	S1210	ochoa	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)	Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250\|UniProtKB:Q6QI06, ECO:0000269\|PubMed:15268862, ECO:0000269\|PubMed:15467718, ECO:0000269\|PubMed:15718470, ECO:0000269\|PubMed:19720745, ECO:0000269\|PubMed:19935711, ECO:0000269\|PubMed:19995915, ECO:0000269\|PubMed:21343617, ECO:0000269\|PubMed:33158864, ECO:0000269\|PubMed:35904232, ECO:0000269\|PubMed:35926713}.
Q7LDG7	RASGRP2	S116	ochoa\|psp	RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein)	Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269\|PubMed:10918068, ECO:0000269\|PubMed:14702343, ECO:0000269\|PubMed:17576779, ECO:0000269\|PubMed:17702895, ECO:0000269\|PubMed:24958846, ECO:0000269\|PubMed:27235135}.
Q7Z4V5	HDGFL2	S369	ochoa	Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)	Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269\|PubMed:25689719, ECO:0000269\|PubMed:26721387, ECO:0000269\|PubMed:32459350}.
Q86V15	CASZ1	S1722	ochoa	Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)	Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269\|PubMed:23639441, ECO:0000269\|PubMed:27693370}.
Q8IWC1	MAP7D3	S457	ochoa	MAP7 domain-containing protein 3	Promotes the assembly and stability of microtubules. {ECO:0000269\|PubMed:22142902, ECO:0000269\|PubMed:24927501}.
Q8IWQ3	BRSK2	S294	ochoa	Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:20026642, ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:22669945, ECO:0000269\|PubMed:22798068, ECO:0000269\|PubMed:23029325}.
Q8IX12	CCAR1	S1078	ochoa	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)	Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250\|UniProtKB:Q8CH18, ECO:0000269\|PubMed:12816952, ECO:0000269\|PubMed:23887938, ECO:0000269\|PubMed:24245781}.
Q8NBJ4	GOLM1	S87	ochoa	Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2)	Unknown. Cellular response protein to viral infection.
Q8NDB2	BANK1	S158	ochoa	B-cell scaffold protein with ankyrin repeats	Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269\|PubMed:11782428}.
Q8NG31	KNL1	S60	ochoa\|psp	Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)	Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250\|UniProtKB:Q66JQ7, ECO:0000269\|PubMed:15502821, ECO:0000269\|PubMed:17981135, ECO:0000269\|PubMed:18045986, ECO:0000269\|PubMed:19893618, ECO:0000269\|PubMed:21199919, ECO:0000269\|PubMed:22000412, ECO:0000269\|PubMed:22331848, ECO:0000269\|PubMed:25308863, ECO:0000269\|PubMed:27881301, ECO:0000269\|PubMed:30100357, ECO:0000269\|PubMed:38459127, ECO:0000269\|PubMed:38459128}.
Q8TAF3	WDR48	S616	ochoa	WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)	Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269\|PubMed:18082604, ECO:0000269\|PubMed:19075014, ECO:0000269\|PubMed:20147293, ECO:0000269\|PubMed:24145035, ECO:0000269\|PubMed:26388029, ECO:0000269\|PubMed:27239033, ECO:0000269\|PubMed:27373336, ECO:0000269\|PubMed:27463890, ECO:0000269\|PubMed:27650958, ECO:0000269\|PubMed:31253762, ECO:0000269\|PubMed:31844045, ECO:0000269\|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269\|PubMed:12196293, ECO:0000269\|PubMed:18032488}.
Q8WWI1	LMO7	S262	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q92793	CREBBP	S1030	ochoa	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269\|PubMed:10490106, ECO:0000269\|PubMed:11154691, ECO:0000269\|PubMed:12738767, ECO:0000269\|PubMed:12929931, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:21131905, ECO:0000269\|PubMed:24207024, ECO:0000269\|PubMed:24616510, ECO:0000269\|PubMed:24939902, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:28790157, ECO:0000269\|PubMed:30540930, ECO:0000269\|PubMed:35675826, ECO:0000269\|PubMed:38128537, ECO:0000269\|PubMed:9707565}.
Q93074	MED12	S557	ochoa	Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269\|PubMed:16565090, ECO:0000269\|PubMed:16595664, ECO:0000269\|PubMed:17000779}.
Q96BN8	OTULIN	S81	ochoa	Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)	Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334). {ECO:0000269\|PubMed:23708998, ECO:0000269\|PubMed:23746843, ECO:0000269\|PubMed:23806334, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:24726323, ECO:0000269\|PubMed:24726327, ECO:0000269\|PubMed:26670046, ECO:0000269\|PubMed:26997266, ECO:0000269\|PubMed:27523608, ECO:0000269\|PubMed:27559085, ECO:0000269\|PubMed:28919039, ECO:0000269\|PubMed:30804083, ECO:0000269\|PubMed:35170849, ECO:0000269\|PubMed:35587511, ECO:0000269\|PubMed:38630025, ECO:0000269\|PubMed:38652464}.
Q96CV9	OPTN	S473	psp	Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269\|PubMed:11834836, ECO:0000269\|PubMed:15837803, ECO:0000269\|PubMed:20085643, ECO:0000269\|PubMed:20174559, ECO:0000269\|PubMed:21617041, ECO:0000269\|PubMed:22854040, ECO:0000269\|PubMed:27534431, ECO:0000269\|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269\|PubMed:20174559, ECO:0000269\|PubMed:27538435, ECO:0000269\|PubMed:9488477}.
Q96EH3	MALSU1	S82	ochoa	Mitochondrial assembly of ribosomal large subunit protein 1	Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). {ECO:0000269\|PubMed:22238375, ECO:0000269\|PubMed:22238376, ECO:0000269\|PubMed:23171548, ECO:0000305\|PubMed:22829778, ECO:0000305\|PubMed:28892042}.
Q96S66	CLCC1	S503	ochoa	Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein)	Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250\|UniProtKB:Q99LI2, ECO:0000269\|PubMed:25698737, ECO:0000269\|PubMed:30157172, ECO:0000269\|PubMed:37142673}.
Q96S90	LYSMD1	S120	ochoa	LysM and putative peptidoglycan-binding domain-containing protein 1	None
Q99081	TCF12	S545	ochoa	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250\|UniProtKB:Q61286, ECO:0000269\|PubMed:32620954}.
Q99549	MPHOSPH8	S20	ochoa	M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)	Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269\|PubMed:20871592, ECO:0000269\|PubMed:26022416, ECO:0000269\|PubMed:28581500, ECO:0000269\|PubMed:29211708, ECO:0000269\|PubMed:30487602}.
Q9BUG6	ZSCAN5A	S245	ochoa	Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495)	May be involved in transcriptional regulation.
Q9BVS4	RIOK2	S369	ochoa	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269\|PubMed:16037817, ECO:0000269\|PubMed:19564402, ECO:0000269\|PubMed:21880710}.
Q9BZQ8	NIBAN1	S639	ochoa	Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A)	Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9C0D5	TANC1	S177	ochoa	Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)	May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H0A0	NAT10	S957	ochoa	RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP)	RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250\|UniProtKB:P53914, ECO:0000269\|PubMed:14592445, ECO:0000269\|PubMed:17631499, ECO:0000269\|PubMed:18082603, ECO:0000269\|PubMed:19303003, ECO:0000269\|PubMed:25411247, ECO:0000269\|PubMed:25653167, ECO:0000269\|PubMed:26882543, ECO:0000269\|PubMed:27993683, ECO:0000269\|PubMed:30165671, ECO:0000269\|PubMed:30449621, ECO:0000269\|PubMed:31722219, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:35679869}.
Q9H5V8	CDCP1	S818	ochoa	CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318)	May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269\|PubMed:11466621, ECO:0000269\|PubMed:12799299, ECO:0000269\|PubMed:15153610, ECO:0000269\|PubMed:16007225, ECO:0000269\|PubMed:16404722, ECO:0000269\|PubMed:8647901}.
Q9H6Z4	RANBP3	S240	ochoa	Ran-binding protein 3 (RanBP3)	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269\|PubMed:11425870, ECO:0000269\|PubMed:11571268, ECO:0000269\|PubMed:11932251, ECO:0000269\|PubMed:19289081, ECO:0000269\|PubMed:9637251}.
Q9H7L9	SUDS3	S39	ochoa	Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)	Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269\|PubMed:12724404, ECO:0000269\|PubMed:21239494}.
Q9HAW7	UGT1A7	S432	psp	UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G)	[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP) (PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161). {ECO:0000269\|PubMed:12181437, ECO:0000269\|PubMed:15470161, ECO:0000269\|PubMed:18004212, ECO:0000269\|PubMed:18052087, ECO:0000269\|PubMed:18674515, ECO:0000269\|PubMed:18719240, ECO:0000269\|PubMed:20610558, ECO:0000269\|PubMed:21422672, ECO:0000269\|PubMed:23360619, ECO:0000269\|PubMed:38211441}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269\|PubMed:18004212, ECO:0000269\|PubMed:20610558, ECO:0000269\|PubMed:23360619}.
Q9HAW8	UGT1A10	S432	psp	UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J)	[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143, PubMed:15231852, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and PGB1 (PubMed:15231852). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269\|PubMed:12181437, ECO:0000269\|PubMed:15231852, ECO:0000269\|PubMed:18004212, ECO:0000269\|PubMed:18052087, ECO:0000269\|PubMed:18674515, ECO:0000269\|PubMed:18719240, ECO:0000269\|PubMed:19545173, ECO:0000269\|PubMed:21422672, ECO:0000269\|PubMed:23288867, ECO:0000269\|PubMed:26220143}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269\|PubMed:18004212, ECO:0000269\|PubMed:20610558}.
Q9NW68	BSDC1	S329	ochoa	BSD domain-containing protein 1	None
Q9NX95	SYBU	S70	ochoa	Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein)	Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269\|PubMed:15459722}.
Q9NZB2	FAM120A	S1044	ochoa	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A)	Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269\|PubMed:19015244}.
Q9P246	STIM2	S603	ochoa	Stromal interaction molecule 2	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269\|PubMed:16005298, ECO:0000269\|PubMed:16860747, ECO:0000269\|PubMed:17905723, ECO:0000269\|PubMed:18160041, ECO:0000269\|PubMed:21217057, ECO:0000269\|PubMed:22464749, ECO:0000269\|PubMed:23359669}.
Q9UKX7	NUP50	S270	ochoa	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250\|UniProtKB:Q9JIH2, ECO:0000269\|PubMed:20016008}.
Q9ULU4	ZMYND8	S465	ochoa	MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)	Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:26655721, ECO:0000269\|PubMed:27477906, ECO:0000269\|PubMed:27732854, ECO:0000269\|PubMed:30134174, ECO:0000269\|PubMed:31965980, ECO:0000269\|PubMed:33323928, ECO:0000269\|PubMed:35916866, ECO:0000269\|PubMed:36064715}.
Q9UN81	L1RE1	S145	ochoa	LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1)	Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269\|PubMed:11158327, ECO:0000269\|PubMed:21937507, ECO:0000269\|PubMed:28806172, ECO:0000269\|PubMed:30122351, ECO:0000269\|PubMed:8945518}.
Q9UNN5	FAF1	S582	ochoa\|psp	FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)	Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250\|UniProtKB:P54731, ECO:0000269\|PubMed:19722279, ECO:0000269\|PubMed:26842564}.
Q9UQ88	CDK11A	S273	ochoa	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269\|PubMed:12501247, ECO:0000269\|PubMed:12624090}.
Q9Y2L9	LRCH1	S393	ochoa	Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81)	Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269\|PubMed:28028151}.
Q9Y4L1	HYOU1	S583	ochoa	Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)	Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250\|UniProtKB:Q9JKR6, ECO:0000269\|PubMed:10037731}.
P17844	DDX5	S422	Sugiyama	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269\|PubMed:12527917, ECO:0000269\|PubMed:15298701, ECO:0000269\|PubMed:15660129, ECO:0000269\|PubMed:17011493, ECO:0000269\|PubMed:17960593, ECO:0000269\|PubMed:18829551, ECO:0000269\|PubMed:19718048, ECO:0000269\|PubMed:21343338}.
P0C0L4	C4A	S1294	Sugiyama	Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; Complement C4b-A (Complement C4b-alpha' chain); Complement C4d-A; Complement C4 gamma chain]	Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269\|PubMed:12878586, ECO:0000269\|PubMed:18204047, ECO:0000269\|PubMed:22949645, ECO:0000269\|PubMed:2395880, ECO:0000269\|PubMed:32769120, ECO:0000269\|PubMed:35428691, ECO:0000269\|PubMed:39914456, ECO:0000269\|PubMed:8538770}.; FUNCTION: [Complement C4b-A]: Non-enzymatic component of C3 and C5 convertases (PubMed:8538770). Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal (PubMed:27738201, PubMed:8538770). It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways (PubMed:12878586, PubMed:18204047, PubMed:2387864, PubMed:6906228). Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (PubMed:8538770). {ECO:0000269\|PubMed:12878586, ECO:0000269\|PubMed:18204047, ECO:0000269\|PubMed:2387864, ECO:0000269\|PubMed:27738201, ECO:0000269\|PubMed:6906228, ECO:0000269\|PubMed:8538770}.; FUNCTION: [C4a anaphylatoxin]: Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway) (PubMed:6167582). While it is strongly similar to anaphylatoxins, its role is unclear (PubMed:25659340). Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays (PubMed:25659340). {ECO:0000269\|PubMed:6167582, ECO:0000303\|PubMed:25659340}.
P0C0L5	C4B	S1294	Sugiyama	Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; Complement C4b-B; C4d-B; Complement C4 gamma chain]	Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269\|PubMed:2395880, ECO:0000269\|PubMed:8538770}.; FUNCTION: [Complement C4b-B]: Non-enzymatic component of C3 and C5 convertases (By similarity). Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal (By similarity). It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways (PubMed:8538770). Complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens, while C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens (PubMed:8538770). {ECO:0000250\|UniProtKB:P0C0L4, ECO:0000269\|PubMed:8538770}.; FUNCTION: [C4a anaphylatoxin]: Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays. {ECO:0000250\|UniProtKB:P0C0L4}.
Q9BT09	CNPY3	S205	Sugiyama	Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)	Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.

Download

reactome_id	name	p	-log10_p
R-HSA-3371568	Attenuation phase	1.099121e-14	13.959
R-HSA-3371571	HSF1-dependent transactivation	4.782841e-13	12.320
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	5.491319e-11	10.260
R-HSA-3371511	HSF1 activation	8.146761e-11	10.089
R-HSA-3371556	Cellular response to heat stress	2.199755e-10	9.658
R-HSA-1640170	Cell Cycle	7.503474e-06	5.125
R-HSA-111465	Apoptotic cleavage of cellular proteins	2.166240e-05	4.664
R-HSA-69278	Cell Cycle, Mitotic	8.325747e-05	4.080
R-HSA-3247509	Chromatin modifying enzymes	2.543855e-04	3.595
R-HSA-75153	Apoptotic execution phase	2.400593e-04	3.620
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	4.438888e-04	3.353
R-HSA-4839726	Chromatin organization	5.080241e-04	3.294
R-HSA-9673013	Diseases of Telomere Maintenance	1.663120e-03	2.779
R-HSA-9006821	Alternative Lengthening of Telomeres (ALT)	1.663120e-03	2.779
R-HSA-9670621	Defective Inhibition of DNA Recombination at Telomere	1.663120e-03	2.779
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	1.663120e-03	2.779
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	1.663120e-03	2.779
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	1.104333e-03	2.957
R-HSA-2262752	Cellular responses to stress	1.511969e-03	2.820
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	1.880261e-03	2.726
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	2.806078e-03	2.552
R-HSA-453274	Mitotic G2-G2/M phases	3.886442e-03	2.410
R-HSA-8943724	Regulation of PTEN gene transcription	4.451787e-03	2.351
R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid ce...	4.425071e-03	2.354
R-HSA-68886	M Phase	4.786122e-03	2.320
R-HSA-8953897	Cellular responses to stimuli	5.255472e-03	2.279
R-HSA-9700645	ALK mutants bind TKIs	5.622356e-03	2.250
R-HSA-9675126	Diseases of mitotic cell cycle	5.748914e-03	2.240
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	6.393509e-03	2.194
R-HSA-5633007	Regulation of TP53 Activity	7.387285e-03	2.132
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	8.479301e-03	2.072
R-HSA-9673766	Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	9.807524e-03	2.008
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	9.912419e-03	2.004
R-HSA-6804757	Regulation of TP53 Degradation	9.480604e-03	2.023
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	1.100650e-02	1.958
R-HSA-9818028	NFE2L2 regulates pentose phosphate pathway genes	1.029513e-02	1.987
R-HSA-6806003	Regulation of TP53 Expression and Degradation	1.237884e-02	1.907
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	1.237884e-02	1.907
R-HSA-380287	Centrosome maturation	1.243213e-02	1.905
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	1.436523e-02	1.843
R-HSA-3214841	PKMTs methylate histone lysines	1.461297e-02	1.835
R-HSA-8878171	Transcriptional regulation by RUNX1	1.584355e-02	1.800
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	1.668361e-02	1.778
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	1.639303e-02	1.785
R-HSA-68911	G2 Phase	1.849650e-02	1.733
R-HSA-72172	mRNA Splicing	1.704072e-02	1.769
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	1.849650e-02	1.733
R-HSA-69618	Mitotic Spindle Checkpoint	1.839073e-02	1.735
R-HSA-174577	Activation of C3 and C5	1.849650e-02	1.733
R-HSA-5357801	Programmed Cell Death	1.759872e-02	1.755
R-HSA-69275	G2/M Transition	2.014411e-02	1.696
R-HSA-109581	Apoptosis	1.933086e-02	1.714
R-HSA-9833576	CDH11 homotypic and heterotypic interactions	2.369964e-02	1.625
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL...	2.193035e-02	1.659
R-HSA-8854518	AURKA Activation by TPX2	2.358785e-02	1.627
R-HSA-141424	Amplification of signal from the kinetochores	2.272060e-02	1.644
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	2.272060e-02	1.644
R-HSA-5357905	Regulation of TNFR1 signaling	2.288947e-02	1.640
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	2.369964e-02	1.625
R-HSA-9764302	Regulation of CDH19 Expression and Function	2.369964e-02	1.625
R-HSA-72163	mRNA Splicing - Major Pathway	2.600804e-02	1.585
R-HSA-68877	Mitotic Prometaphase	2.521389e-02	1.598
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	2.620537e-02	1.582
R-HSA-212165	Epigenetic regulation of gene expression	2.775045e-02	1.557
R-HSA-9764265	Regulation of CDH1 Expression and Function	2.901566e-02	1.537
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	2.901566e-02	1.537
R-HSA-5689880	Ub-specific processing proteases	2.901566e-02	1.537
R-HSA-427413	NoRC negatively regulates rRNA expression	3.099855e-02	1.509
R-HSA-114508	Effects of PIP2 hydrolysis	3.165355e-02	1.500
R-HSA-9764560	Regulation of CDH1 Gene Transcription	2.940866e-02	1.532
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	3.564197e-02	1.448
R-HSA-8948747	Regulation of PTEN localization	3.564197e-02	1.448
R-HSA-72731	Recycling of eIF2:GDP	3.564197e-02	1.448
R-HSA-5688426	Deubiquitination	3.575382e-02	1.447
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	3.852525e-02	1.414
R-HSA-3214815	HDACs deacetylate histones	4.014971e-02	1.396
R-HSA-6807070	PTEN Regulation	4.384807e-02	1.358
R-HSA-75893	TNF signaling	4.244726e-02	1.372
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	4.231347e-02	1.374
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	4.884606e-02	1.311
R-HSA-5617833	Cilium Assembly	4.808015e-02	1.318
R-HSA-8953750	Transcriptional Regulation by E2F6	4.842626e-02	1.315
R-HSA-68882	Mitotic Anaphase	4.967586e-02	1.304
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	4.784789e-02	1.320
R-HSA-9833482	PKR-mediated signaling	4.784789e-02	1.320
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	4.980706e-02	1.303
R-HSA-2555396	Mitotic Metaphase and Anaphase	5.095768e-02	1.293
R-HSA-9645722	Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	5.717508e-02	1.243
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	8.452732e-02	1.073
R-HSA-5674404	PTEN Loss of Function in Cancer	8.452732e-02	1.073
R-HSA-5619054	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit...	8.452732e-02	1.073
R-HSA-9818035	NFE2L2 regulating ER-stress associated genes	1.619236e-01	0.791
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	5.689931e-02	1.245
R-HSA-111463	SMAC (DIABLO) binds to IAPs	1.862429e-01	0.730
R-HSA-111464	SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	1.862429e-01	0.730
R-HSA-9818026	NFE2L2 regulating inflammation associated genes	1.862429e-01	0.730
R-HSA-111469	SMAC, XIAP-regulated apoptotic response	2.098580e-01	0.678
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	2.098580e-01	0.678
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	9.024633e-02	1.045
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	9.024633e-02	1.045
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	9.024633e-02	1.045
R-HSA-9842640	Signaling by LTK in cancer	2.327892e-01	0.633
R-HSA-110357	Displacement of DNA glycosylase by APEX1	2.550562e-01	0.593
R-HSA-114516	Disinhibition of SNARE formation	2.550562e-01	0.593
R-HSA-445095	Interaction between L1 and Ankyrins	7.492303e-02	1.125
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	1.377225e-01	0.861
R-HSA-196025	Formation of annular gap junctions	2.766783e-01	0.558
R-HSA-9615710	Late endosomal microautophagy	8.574748e-02	1.067
R-HSA-9818032	NFE2L2 regulating MDR associated enzymes	2.976741e-01	0.526
R-HSA-190873	Gap junction degradation	2.976741e-01	0.526
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	1.682985e-01	0.774
R-HSA-159227	Transport of the SLBP independent Mature mRNA	1.092170e-01	0.962
R-HSA-164843	2-LTR circle formation	3.180617e-01	0.497
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	1.154348e-01	0.938
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	1.217825e-01	0.914
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	1.217825e-01	0.914
R-HSA-112308	Presynaptic depolarization and calcium channel opening	3.378587e-01	0.471
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	6.071548e-02	1.217
R-HSA-380259	Loss of Nlp from mitotic centrosomes	6.071548e-02	1.217
R-HSA-72187	mRNA 3'-end processing	1.029665e-01	0.987
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	1.552874e-01	0.809
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	1.623050e-01	0.790
R-HSA-3000484	Scavenging by Class F Receptors	3.757487e-01	0.425
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	2.536999e-01	0.596
R-HSA-774815	Nucleosome assembly	2.061932e-01	0.686
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	2.061932e-01	0.686
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	2.862073e-01	0.543
R-HSA-177504	Retrograde neurotrophin signalling	4.114748e-01	0.386
R-HSA-1663150	The activation of arylsulfatases	4.114748e-01	0.386
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	1.703003e-01	0.769
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	2.970202e-01	0.527
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	2.970202e-01	0.527
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	4.285652e-01	0.368
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	1.604757e-01	0.795
R-HSA-9668328	Sealing of the nuclear envelope (NE) by ESCRT-III	3.185623e-01	0.497
R-HSA-1855170	IPs transport between nucleus and cytosol	3.185623e-01	0.497
R-HSA-5696394	DNA Damage Recognition in GG-NER	3.292767e-01	0.482
R-HSA-390522	Striated Muscle Contraction	3.292767e-01	0.482
R-HSA-176412	Phosphorylation of the APC/C	4.451603e-01	0.351
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	4.451603e-01	0.351
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	4.451603e-01	0.351
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	4.451603e-01	0.351
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	2.176730e-01	0.662
R-HSA-5696400	Dual Incision in GG-NER	3.399443e-01	0.469
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	3.505588e-01	0.455
R-HSA-69205	G1/S-Specific Transcription	3.611142e-01	0.442
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	2.745243e-01	0.561
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	3.237611e-01	0.490
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	4.921152e-01	0.308
R-HSA-418217	G beta:gamma signalling through PLC beta	4.921152e-01	0.308
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	4.026411e-01	0.395
R-HSA-9670095	Inhibition of DNA recombination at telomere	4.026411e-01	0.395
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	4.128260e-01	0.384
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	5.068684e-01	0.295
R-HSA-9709603	Impaired BRCA2 binding to PALB2	5.068684e-01	0.295
R-HSA-167161	HIV Transcription Initiation	4.229241e-01	0.374
R-HSA-75953	RNA Polymerase II Transcription Initiation	4.229241e-01	0.374
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	5.211939e-01	0.283
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	5.211939e-01	0.283
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	5.211939e-01	0.283
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	5.211939e-01	0.283
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	4.623811e-01	0.335
R-HSA-9818030	NFE2L2 regulating tumorigenic genes	3.938744e-01	0.405
R-HSA-5620916	VxPx cargo-targeting to cilium	5.211939e-01	0.283
R-HSA-1538133	G0 and Early G1	1.031344e-01	0.987
R-HSA-5693607	Processing of DNA double-strand break ends	4.869489e-01	0.313
R-HSA-354192	Integrin signaling	1.092170e-01	0.962
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	8.625764e-02	1.064
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	4.623811e-01	0.335
R-HSA-9762292	Regulation of CDH11 function	5.689931e-02	1.245
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	9.930213e-02	1.003
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	1.085986e-01	0.964
R-HSA-9932451	SWI/SNF chromatin remodelers	6.475572e-02	1.189
R-HSA-9932444	ATP-dependent chromatin remodelers	6.475572e-02	1.189
R-HSA-77595	Processing of Intronless Pre-mRNAs	1.278288e-01	0.893
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	3.378587e-01	0.471
R-HSA-5696395	Formation of Incision Complex in GG-NER	1.623050e-01	0.790
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	5.088454e-01	0.293
R-HSA-5693548	Sensing of DNA Double Strand Breaks	3.570822e-01	0.447
R-HSA-76009	Platelet Aggregation (Plug Formation)	2.061932e-01	0.686
R-HSA-5693532	DNA Double-Strand Break Repair	1.357775e-01	0.867
R-HSA-5693606	DNA Double Strand Break Response	7.287212e-02	1.137
R-HSA-9842860	Regulation of endogenous retroelements	1.195778e-01	0.922
R-HSA-191650	Regulation of gap junction activity	1.619236e-01	0.791
R-HSA-9931529	Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	1.862429e-01	0.730
R-HSA-2465910	MASTL Facilitates Mitotic Progression	2.976741e-01	0.526
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	1.623050e-01	0.790
R-HSA-8951936	RUNX3 regulates p14-ARF	3.757487e-01	0.425
R-HSA-9931530	Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	3.757487e-01	0.425
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	2.645383e-01	0.578
R-HSA-399719	Trafficking of AMPA receptors	2.970202e-01	0.527
R-HSA-9764561	Regulation of CDH1 Function	2.998259e-01	0.523
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	2.428717e-01	0.615
R-HSA-9909396	Circadian clock	7.431150e-02	1.129
R-HSA-525793	Myogenesis	6.975500e-02	1.156
R-HSA-8941856	RUNX3 regulates NOTCH signaling	3.757487e-01	0.425
R-HSA-73776	RNA Polymerase II Promoter Escape	4.428457e-01	0.354
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	2.550562e-01	0.593
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	9.139459e-02	1.039
R-HSA-5357786	TNFR1-induced proapoptotic signaling	1.787330e-01	0.748
R-HSA-5576893	Phase 2 - plateau phase	4.612745e-01	0.336
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	4.769216e-01	0.322
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	4.921152e-01	0.308
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	4.229241e-01	0.374
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	4.026411e-01	0.395
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	4.026411e-01	0.395
R-HSA-1169408	ISG15 antiviral mechanism	1.008375e-01	0.996
R-HSA-2467813	Separation of Sister Chromatids	9.273197e-02	1.033
R-HSA-5099900	WNT5A-dependent internalization of FZD4	1.181144e-01	0.928
R-HSA-9766229	Degradation of CDH1	2.367840e-01	0.626
R-HSA-6807878	COPI-mediated anterograde transport	3.863547e-01	0.413
R-HSA-73933	Resolution of Abasic Sites (AP sites)	4.128260e-01	0.384
R-HSA-9843745	Adipogenesis	4.350680e-01	0.361
R-HSA-399997	Acetylcholine regulates insulin secretion	1.278288e-01	0.893
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	3.570822e-01	0.447
R-HSA-9818027	NFE2L2 regulating anti-oxidant/detoxification enzymes	3.292767e-01	0.482
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	5.211939e-01	0.283
R-HSA-437239	Recycling pathway of L1	4.815093e-01	0.317
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	3.397256e-01	0.469
R-HSA-6802957	Oncogenic MAPK signaling	2.940232e-01	0.532
R-HSA-8943723	Regulation of PTEN mRNA translation	2.105534e-01	0.677
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	3.611142e-01	0.442
R-HSA-111471	Apoptotic factor-mediated response	1.477769e-01	0.830
R-HSA-1257604	PIP3 activates AKT signaling	2.224077e-01	0.653
R-HSA-674695	RNA Polymerase II Pre-transcription Events	4.341447e-01	0.362
R-HSA-5205647	Mitophagy	3.399443e-01	0.469
R-HSA-74158	RNA Polymerase III Transcription	3.611142e-01	0.442
R-HSA-5620920	Cargo trafficking to the periciliary membrane	4.108981e-01	0.386
R-HSA-77042	Formation of editosomes by ADAR proteins	5.717508e-02	1.243
R-HSA-75064	mRNA Editing: A to I Conversion	1.110877e-01	0.954
R-HSA-75102	C6 deamination of adenosine	1.110877e-01	0.954
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	1.619236e-01	0.791
R-HSA-425381	Bicarbonate transporters	6.475480e-02	1.189
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	1.862429e-01	0.730
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	7.294834e-02	1.137
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	9.024633e-02	1.045
R-HSA-434313	Intracellular metabolism of fatty acids regulates insulin secretion	2.327892e-01	0.633
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	1.181144e-01	0.928
R-HSA-2470946	Cohesin Loading onto Chromatin	2.550562e-01	0.593
R-HSA-446107	Type I hemidesmosome assembly	2.766783e-01	0.558
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	1.477769e-01	0.830
R-HSA-4419969	Depolymerization of the Nuclear Lamina	1.477769e-01	0.830
R-HSA-176974	Unwinding of DNA	2.976741e-01	0.526
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	3.180617e-01	0.497
R-HSA-192814	vRNA Synthesis	3.378587e-01	0.471
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	1.483683e-01	0.829
R-HSA-8866427	VLDLR internalisation and degradation	3.757487e-01	0.425
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	3.938744e-01	0.405
R-HSA-73856	RNA Polymerase II Transcription Termination	1.481406e-01	0.829
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	2.753771e-01	0.560
R-HSA-162588	Budding and maturation of HIV virion	2.970202e-01	0.527
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	3.292767e-01	0.482
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	4.612745e-01	0.336
R-HSA-432720	Lysosome Vesicle Biogenesis	3.611142e-01	0.442
R-HSA-180910	Vpr-mediated nuclear import of PICs	3.716051e-01	0.430
R-HSA-191859	snRNP Assembly	3.157777e-01	0.501
R-HSA-194441	Metabolism of non-coding RNA	3.157777e-01	0.501
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	4.921152e-01	0.308
R-HSA-73980	RNA Polymerase III Transcription Termination	4.921152e-01	0.308
R-HSA-500657	Presynaptic function of Kainate receptors	4.921152e-01	0.308
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	4.623811e-01	0.335
R-HSA-9613829	Chaperone Mediated Autophagy	4.921152e-01	0.308
R-HSA-68875	Mitotic Prophase	2.055530e-01	0.687
R-HSA-9755511	KEAP1-NFE2L2 pathway	3.795575e-01	0.421
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	4.264314e-01	0.370
R-HSA-2980766	Nuclear Envelope Breakdown	1.272027e-01	0.896
R-HSA-9617629	Regulation of FOXO transcriptional activity by acetylation	3.757487e-01	0.425
R-HSA-177243	Interactions of Rev with host cellular proteins	1.623050e-01	0.790
R-HSA-9006925	Intracellular signaling by second messengers	2.726542e-01	0.564
R-HSA-447043	Neurofascin interactions	2.327892e-01	0.633
R-HSA-912631	Regulation of signaling by CBL	5.068684e-01	0.295
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	3.873659e-01	0.412
R-HSA-2132295	MHC class II antigen presentation	3.775705e-01	0.423
R-HSA-199992	trans-Golgi Network Vesicle Budding	4.186818e-01	0.378
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	3.938744e-01	0.405
R-HSA-73894	DNA Repair	3.306699e-01	0.481
R-HSA-111448	Activation of NOXA and translocation to mitochondria	1.619236e-01	0.791
R-HSA-390648	Muscarinic acetylcholine receptors	1.862429e-01	0.730
R-HSA-139915	Activation of PUMA and translocation to mitochondria	2.550562e-01	0.593
R-HSA-450341	Activation of the AP-1 family of transcription factors	2.976741e-01	0.526
R-HSA-6811438	Intra-Golgi traffic	5.833471e-02	1.234
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	2.212873e-01	0.655
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	2.137580e-01	0.670
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	3.292767e-01	0.482
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	5.211939e-01	0.283
R-HSA-3214847	HATs acetylate histones	4.060887e-01	0.391
R-HSA-400451	Free fatty acids regulate insulin secretion	2.105534e-01	0.677
R-HSA-1482801	Acyl chain remodelling of PS	2.320638e-01	0.634
R-HSA-6790901	rRNA modification in the nucleus and cytosol	3.476999e-01	0.459
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	3.873659e-01	0.412
R-HSA-73864	RNA Polymerase I Transcription	4.645921e-01	0.333
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	4.464531e-01	0.350
R-HSA-2559583	Cellular Senescence	7.322585e-02	1.135
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	1.165904e-01	0.933
R-HSA-199991	Membrane Trafficking	1.353672e-01	0.868
R-HSA-73886	Chromosome Maintenance	2.101143e-01	0.678
R-HSA-352238	Breakdown of the nuclear lamina	8.452732e-02	1.073
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	1.862429e-01	0.730
R-HSA-2161517	Abacavir transmembrane transport	2.327892e-01	0.633
R-HSA-9909505	Modulation of host responses by IFN-stimulated genes	1.377225e-01	0.861
R-HSA-9828211	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	2.766783e-01	0.558
R-HSA-75072	mRNA Editing	2.976741e-01	0.526
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	3.570822e-01	0.447
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	3.570822e-01	0.447
R-HSA-9824878	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	3.570822e-01	0.447
R-HSA-168276	NS1 Mediated Effects on Host Pathways	1.552874e-01	0.809
R-HSA-5218921	VEGFR2 mediated cell proliferation	2.320638e-01	0.634
R-HSA-5689901	Metalloprotease DUBs	2.428717e-01	0.615
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	3.185623e-01	0.497
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	4.451603e-01	0.351
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	4.612745e-01	0.336
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	5.068684e-01	0.295
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	4.719973e-01	0.326
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	4.795457e-01	0.319
R-HSA-373760	L1CAM interactions	3.371948e-01	0.472
R-HSA-5653656	Vesicle-mediated transport	3.983584e-01	0.400
R-HSA-901042	Calnexin/calreticulin cycle	3.399443e-01	0.469
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	5.647096e-02	1.248
R-HSA-1852241	Organelle biogenesis and maintenance	8.165707e-02	1.088
R-HSA-109606	Intrinsic Pathway for Apoptosis	2.918648e-01	0.535
R-HSA-5210891	Uptake and function of anthrax toxins	1.377225e-01	0.861
R-HSA-2559580	Oxidative Stress Induced Senescence	2.417637e-01	0.617
R-HSA-8953854	Metabolism of RNA	3.102516e-01	0.508
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	4.128260e-01	0.384
R-HSA-157858	Gap junction trafficking and regulation	5.002127e-01	0.301
R-HSA-9818749	Regulation of NFE2L2 gene expression	2.327892e-01	0.633
R-HSA-1679131	Trafficking and processing of endosomal TLR	3.757487e-01	0.425
R-HSA-9759475	Regulation of CDH11 Expression and Function	2.753771e-01	0.560
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	3.185623e-01	0.497
R-HSA-9768727	Regulation of CDH1 posttranslational processing and trafficking to plasma membra...	3.292767e-01	0.482
R-HSA-180746	Nuclear import of Rev protein	3.399443e-01	0.469
R-HSA-6784531	tRNA processing in the nucleus	3.397256e-01	0.469
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	4.128260e-01	0.384
R-HSA-5655302	Signaling by FGFR1 in disease	4.229241e-01	0.374
R-HSA-1839124	FGFR1 mutant receptor activation	3.185623e-01	0.497
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	2.367840e-01	0.626
R-HSA-418990	Adherens junctions interactions	9.733512e-02	1.012
R-HSA-421270	Cell-cell junction organization	1.084343e-01	0.965
R-HSA-5621575	CD209 (DC-SIGN) signaling	2.212873e-01	0.655
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	3.185623e-01	0.497
R-HSA-918233	TRAF3-dependent IRF activation pathway	4.612745e-01	0.336
R-HSA-446728	Cell junction organization	6.114862e-02	1.214
R-HSA-1632852	Macroautophagy	4.968596e-01	0.304
R-HSA-69620	Cell Cycle Checkpoints	7.126941e-02	1.147
R-HSA-2559585	Oncogene Induced Senescence	1.282549e-01	0.892
R-HSA-76002	Platelet activation, signaling and aggregation	3.666895e-01	0.436
R-HSA-9706374	FLT3 signaling through SRC family kinases	1.619236e-01	0.791
R-HSA-447038	NrCAM interactions	1.862429e-01	0.730
R-HSA-444821	Relaxin receptors	2.098580e-01	0.678
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	9.024633e-02	1.045
R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors	2.976741e-01	0.526
R-HSA-111461	Cytochrome c-mediated apoptotic response	3.570822e-01	0.447
R-HSA-1236977	Endosomal/Vacuolar pathway	3.570822e-01	0.447
R-HSA-68884	Mitotic Telophase/Cytokinesis	3.570822e-01	0.447
R-HSA-9839394	TGFBR3 expression	2.320638e-01	0.634
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	4.451603e-01	0.351
R-HSA-176033	Interactions of Vpr with host cellular proteins	4.026411e-01	0.395
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	4.128260e-01	0.384
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	4.128260e-01	0.384
R-HSA-113510	E2F mediated regulation of DNA replication	5.068684e-01	0.295
R-HSA-69473	G2/M DNA damage checkpoint	4.341447e-01	0.362
R-HSA-1500931	Cell-Cell communication	7.571850e-02	1.121
R-HSA-162599	Late Phase of HIV Life Cycle	1.958323e-01	0.708
R-HSA-3214842	HDMs demethylate histones	2.320638e-01	0.634
R-HSA-156588	Glucuronidation	1.123880e-01	0.949
R-HSA-418597	G alpha (z) signalling events	2.839188e-01	0.547
R-HSA-389357	CD28 dependent PI3K/Akt signaling	2.536999e-01	0.596
R-HSA-162592	Integration of provirus	3.570822e-01	0.447
R-HSA-74160	Gene expression (Transcription)	2.878229e-01	0.541
R-HSA-73887	Death Receptor Signaling	3.951339e-01	0.403
R-HSA-8964011	HDL clearance	2.327892e-01	0.633
R-HSA-164944	Nef and signal transduction	2.327892e-01	0.633
R-HSA-447041	CHL1 interactions	2.550562e-01	0.593
R-HSA-9707616	Heme signaling	5.787096e-02	1.238
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	6.940942e-02	1.159
R-HSA-3270619	IRF3-mediated induction of type I IFN	4.285652e-01	0.368
R-HSA-9614657	FOXO-mediated transcription of cell death genes	4.921152e-01	0.308
R-HSA-6783310	Fanconi Anemia Pathway	4.623811e-01	0.335
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	4.815093e-01	0.317
R-HSA-9816359	Maternal to zygotic transition (MZT)	2.193421e-01	0.659
R-HSA-373755	Semaphorin interactions	3.476999e-01	0.459
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	5.231684e-01	0.281
R-HSA-162587	HIV Life Cycle	1.485151e-01	0.828
R-HSA-1500620	Meiosis	5.160352e-01	0.287
R-HSA-168255	Influenza Infection	2.317578e-01	0.635
R-HSA-9833110	RSV-host interactions	4.451410e-01	0.352
R-HSA-3700989	Transcriptional Regulation by TP53	8.642222e-02	1.063
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	4.612745e-01	0.336
R-HSA-69242	S Phase	3.639913e-01	0.439
R-HSA-4420097	VEGFA-VEGFR2 Pathway	8.980081e-02	1.047
R-HSA-69231	Cyclin D associated events in G1	1.986916e-01	0.702
R-HSA-69236	G1 Phase	1.986916e-01	0.702
R-HSA-449836	Other interleukin signaling	5.068684e-01	0.295
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	4.623811e-01	0.335
R-HSA-913531	Interferon Signaling	3.056234e-01	0.515
R-HSA-6804760	Regulation of TP53 Activity through Methylation	1.477769e-01	0.830
R-HSA-9627069	Regulation of the apoptosome activity	3.180617e-01	0.497
R-HSA-5689877	Josephin domain DUBs	3.180617e-01	0.497
R-HSA-73762	RNA Polymerase I Transcription Initiation	1.838977e-01	0.735
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	3.185623e-01	0.497
R-HSA-8964043	Plasma lipoprotein clearance	3.923732e-01	0.406
R-HSA-194138	Signaling by VEGF	1.227485e-01	0.911
R-HSA-162906	HIV Infection	3.060395e-01	0.514
R-HSA-6794361	Neurexins and neuroligins	2.602105e-01	0.585
R-HSA-1483249	Inositol phosphate metabolism	4.958920e-01	0.305
R-HSA-163765	ChREBP activates metabolic gene expression	6.475480e-02	1.189
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	1.512047e-01	0.820
R-HSA-373753	Nephrin family interactions	5.211939e-01	0.283
R-HSA-9020956	Interleukin-27 signaling	3.180617e-01	0.497
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	2.976741e-01	0.526
R-HSA-9856872	Malate-aspartate shuttle	4.114748e-01	0.386
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	2.747387e-01	0.561
R-HSA-392517	Rap1 signalling	5.068684e-01	0.295
R-HSA-9700206	Signaling by ALK in cancer	2.747387e-01	0.561
R-HSA-3214858	RMTs methylate histone arginines	1.986916e-01	0.702
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	3.570822e-01	0.447
R-HSA-5218920	VEGFR2 mediated vascular permeability	1.694160e-01	0.771
R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	4.612745e-01	0.336
R-HSA-71240	Tryptophan catabolism	4.026411e-01	0.395
R-HSA-70171	Glycolysis	4.126411e-01	0.384
R-HSA-170834	Signaling by TGF-beta Receptor Complex	3.929439e-01	0.406
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	5.123526e-01	0.290
R-HSA-9683686	Maturation of spike protein	3.180617e-01	0.497
R-HSA-163685	Integration of energy metabolism	2.972830e-01	0.527
R-HSA-8852135	Protein ubiquitination	4.418194e-01	0.355
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	4.030825e-01	0.395
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	1.590771e-01	0.798
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	1.181144e-01	0.928
R-HSA-430116	GP1b-IX-V activation signalling	2.976741e-01	0.526
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	2.105534e-01	0.677
R-HSA-198323	AKT phosphorylates targets in the cytosol	3.757487e-01	0.425
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	2.862073e-01	0.543
R-HSA-389356	Co-stimulation by CD28	4.909150e-01	0.309
R-HSA-9006936	Signaling by TGFB family members	4.262202e-01	0.370
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	2.976741e-01	0.526
R-HSA-111458	Formation of apoptosome	3.180617e-01	0.497
R-HSA-8949215	Mitochondrial calcium ion transport	1.892631e-01	0.723
R-HSA-446353	Cell-extracellular matrix interactions	4.285652e-01	0.368
R-HSA-73854	RNA Polymerase I Promoter Clearance	4.494535e-01	0.347
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	2.552574e-01	0.593
R-HSA-9682706	Replication of the SARS-CoV-1 genome	9.024633e-02	1.045
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	2.998259e-01	0.523
R-HSA-9958790	SLC-mediated transport of inorganic anions	3.820264e-01	0.418
R-HSA-9694686	Replication of the SARS-CoV-2 genome	1.377225e-01	0.861
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	1.477769e-01	0.830
R-HSA-1295596	Spry regulation of FGF signaling	4.285652e-01	0.368
R-HSA-9856532	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	5.068684e-01	0.295
R-HSA-6794362	Protein-protein interactions at synapses	5.160352e-01	0.287
R-HSA-9839373	Signaling by TGFBR3	4.719973e-01	0.326
R-HSA-9768919	NPAS4 regulates expression of target genes	1.217825e-01	0.914
R-HSA-9671555	Signaling by PDGFR in disease	1.892631e-01	0.723
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	2.536999e-01	0.596
R-HSA-9754706	Atorvastatin ADME	4.451603e-01	0.351
R-HSA-9706369	Negative regulation of FLT3	4.451603e-01	0.351
R-HSA-9679191	Potential therapeutics for SARS	2.290402e-01	0.640
R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	9.930213e-02	1.003
R-HSA-8984722	Interleukin-35 Signalling	3.757487e-01	0.425
R-HSA-8853884	Transcriptional Regulation by VENTX	4.128260e-01	0.384
R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	1.579745e-01	0.801
R-HSA-9694631	Maturation of nucleoprotein	1.579745e-01	0.801
R-HSA-8983711	OAS antiviral response	3.757487e-01	0.425
R-HSA-9634815	Transcriptional Regulation by NPAS4	2.602105e-01	0.585
R-HSA-381038	XBP1(S) activates chaperone genes	6.422746e-02	1.192
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	4.869489e-01	0.313
R-HSA-381119	Unfolded Protein Response (UPR)	1.799990e-01	0.745
R-HSA-168316	Assembly of Viral Components at the Budding Site	1.862429e-01	0.730
R-HSA-381070	IRE1alpha activates chaperones	8.058733e-02	1.094
R-HSA-5218859	Regulated Necrosis	3.873659e-01	0.412
R-HSA-9031628	NGF-stimulated transcription	4.909150e-01	0.309
R-HSA-9830364	Formation of the nephric duct	2.320638e-01	0.634
R-HSA-1834941	STING mediated induction of host immune responses	5.068684e-01	0.295
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	2.536999e-01	0.596
R-HSA-168268	Virus Assembly and Release	4.451603e-01	0.351
R-HSA-9607240	FLT3 Signaling	4.128260e-01	0.384
R-HSA-9694635	Translation of Structural Proteins	4.570450e-01	0.340
R-HSA-9679506	SARS-CoV Infections	4.315397e-01	0.365
R-HSA-5620971	Pyroptosis	2.645383e-01	0.578
R-HSA-9772572	Early SARS-CoV-2 Infection Events	1.323146e-01	0.878
R-HSA-9749641	Aspirin ADME	4.264314e-01	0.370
R-HSA-9679504	Translation of Replicase and Assembly of the Replication Transcription Complex	1.477769e-01	0.830
R-HSA-2028269	Signaling by Hippo	4.769216e-01	0.322
R-HSA-9694676	Translation of Replicase and Assembly of the Replication Transcription Complex	1.998744e-01	0.699
R-HSA-9694516	SARS-CoV-2 Infection	5.247097e-01	0.280
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	5.274419e-01	0.278
R-HSA-5339562	Uptake and actions of bacterial toxins	5.274419e-01	0.278
R-HSA-453279	Mitotic G1 phase and G1/S transition	5.294892e-01	0.276
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	5.302436e-01	0.276
R-HSA-72737	Cap-dependent Translation Initiation	5.326268e-01	0.274
R-HSA-72613	Eukaryotic Translation Initiation	5.326268e-01	0.274
R-HSA-199977	ER to Golgi Anterograde Transport	5.348371e-01	0.272
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	5.351041e-01	0.272
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	5.351041e-01	0.272
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	5.351041e-01	0.272
R-HSA-9819196	Zygotic genome activation (ZGA)	5.351041e-01	0.272
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	5.351041e-01	0.272
R-HSA-210991	Basigin interactions	5.351041e-01	0.272
R-HSA-162594	Early Phase of HIV Life Cycle	5.351041e-01	0.272
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	5.362926e-01	0.271
R-HSA-8948751	Regulation of PTEN stability and activity	5.362926e-01	0.271
R-HSA-432722	Golgi Associated Vesicle Biogenesis	5.362926e-01	0.271
R-HSA-445355	Smooth Muscle Contraction	5.362926e-01	0.271
R-HSA-8956320	Nucleotide biosynthesis	5.362926e-01	0.271
R-HSA-1221632	Meiotic synapsis	5.362926e-01	0.271
R-HSA-390466	Chaperonin-mediated protein folding	5.372600e-01	0.270
R-HSA-70268	Pyruvate metabolism	5.372600e-01	0.270
R-HSA-447115	Interleukin-12 family signaling	5.372600e-01	0.270
R-HSA-9007101	Rab regulation of trafficking	5.386209e-01	0.269
R-HSA-1592230	Mitochondrial biogenesis	5.386209e-01	0.269
R-HSA-70326	Glucose metabolism	5.386209e-01	0.269
R-HSA-9663891	Selective autophagy	5.442163e-01	0.264
R-HSA-5693538	Homology Directed Repair	5.445760e-01	0.264
R-HSA-2219528	PI3K/AKT Signaling in Cancer	5.445760e-01	0.264
R-HSA-72649	Translation initiation complex formation	5.450288e-01	0.264
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	5.486110e-01	0.261
R-HSA-9705462	Inactivation of CSF3 (G-CSF) signaling	5.486110e-01	0.261
R-HSA-8876384	Listeria monocytogenes entry into host cells	5.486110e-01	0.261
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	5.486110e-01	0.261
R-HSA-9753281	Paracetamol ADME	5.536496e-01	0.257
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	5.617263e-01	0.250
R-HSA-6803529	FGFR2 alternative splicing	5.617263e-01	0.250
R-HSA-350054	Notch-HLH transcription pathway	5.617263e-01	0.250
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	5.617263e-01	0.250
R-HSA-8964038	LDL clearance	5.617263e-01	0.250
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	5.617263e-01	0.250
R-HSA-72702	Ribosomal scanning and start codon recognition	5.621544e-01	0.250
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	5.621544e-01	0.250
R-HSA-9759194	Nuclear events mediated by NFE2L2	5.621997e-01	0.250
R-HSA-1912408	Pre-NOTCH Transcription and Translation	5.647156e-01	0.248
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	5.744613e-01	0.241
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	5.744613e-01	0.241
R-HSA-1989781	PPARA activates gene expression	5.765737e-01	0.239
R-HSA-391251	Protein folding	5.780654e-01	0.238
R-HSA-9772573	Late SARS-CoV-2 Infection Events	5.780654e-01	0.238
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	5.788138e-01	0.237
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	5.788138e-01	0.237
R-HSA-162909	Host Interactions of HIV factors	5.794463e-01	0.237
R-HSA-9612973	Autophagy	5.816515e-01	0.235
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	5.866965e-01	0.232
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	5.868270e-01	0.231
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	5.868270e-01	0.231
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	5.868270e-01	0.231
R-HSA-9836573	Mitochondrial RNA degradation	5.868270e-01	0.231
R-HSA-8863678	Neurodegenerative Diseases	5.868270e-01	0.231
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	5.868270e-01	0.231
R-HSA-8873719	RAB geranylgeranylation	5.950042e-01	0.225
R-HSA-983189	Kinesins	5.950042e-01	0.225
R-HSA-1660661	Sphingolipid de novo biosynthesis	5.950042e-01	0.225
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	5.988341e-01	0.223
R-HSA-174411	Polymerase switching on the C-strand of the telomere	5.988341e-01	0.223
R-HSA-420029	Tight junction interactions	5.988341e-01	0.223
R-HSA-400685	Sema4D in semaphorin signaling	5.988341e-01	0.223
R-HSA-1266695	Interleukin-7 signaling	5.988341e-01	0.223
R-HSA-69481	G2/M Checkpoints	6.018268e-01	0.221
R-HSA-114608	Platelet degranulation	6.018268e-01	0.221
R-HSA-168325	Viral Messenger RNA Synthesis	6.029232e-01	0.220
R-HSA-112043	PLC beta mediated events	6.029232e-01	0.220
R-HSA-73857	RNA Polymerase II Transcription	6.091400e-01	0.215
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	6.102934e-01	0.214
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	6.102934e-01	0.214
R-HSA-5607764	CLEC7A (Dectin-1) signaling	6.102934e-01	0.214
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	6.104930e-01	0.214
R-HSA-3295583	TRP channels	6.104930e-01	0.214
R-HSA-2161522	Abacavir ADME	6.104930e-01	0.214
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	6.104930e-01	0.214
R-HSA-9616222	Transcriptional regulation of granulopoiesis	6.107247e-01	0.214
R-HSA-8878159	Transcriptional regulation by RUNX3	6.165382e-01	0.210
R-HSA-157579	Telomere Maintenance	6.165382e-01	0.210
R-HSA-73863	RNA Polymerase I Transcription Termination	6.218137e-01	0.206
R-HSA-8949613	Cristae formation	6.218137e-01	0.206
R-HSA-3928663	EPHA-mediated growth cone collapse	6.218137e-01	0.206
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	6.218137e-01	0.206
R-HSA-901032	ER Quality Control Compartment (ERQC)	6.218137e-01	0.206
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	6.218137e-01	0.206
R-HSA-8957275	Post-translational protein phosphorylation	6.227151e-01	0.206
R-HSA-422356	Regulation of insulin secretion	6.227151e-01	0.206
R-HSA-9619483	Activation of AMPK downstream of NMDARs	6.328061e-01	0.199
R-HSA-5576892	Phase 0 - rapid depolarisation	6.328061e-01	0.199
R-HSA-9757110	Prednisone ADME	6.328061e-01	0.199
R-HSA-451326	Activation of kainate receptors upon glutamate binding	6.328061e-01	0.199
R-HSA-5654732	Negative regulation of FGFR3 signaling	6.328061e-01	0.199
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	6.334263e-01	0.198
R-HSA-8856688	Golgi-to-ER retrograde transport	6.340167e-01	0.198
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	6.407602e-01	0.193
R-HSA-9709570	Impaired BRCA2 binding to RAD51	6.434797e-01	0.191
R-HSA-9674555	Signaling by CSF3 (G-CSF)	6.434797e-01	0.191
R-HSA-5334118	DNA methylation	6.434797e-01	0.191
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	6.434797e-01	0.191
R-HSA-5654733	Negative regulation of FGFR4 signaling	6.434797e-01	0.191
R-HSA-112040	G-protein mediated events	6.479782e-01	0.188
R-HSA-9830369	Kidney development	6.479782e-01	0.188
R-HSA-9824446	Viral Infection Pathways	6.508318e-01	0.187
R-HSA-68962	Activation of the pre-replicative complex	6.538436e-01	0.185
R-HSA-76046	RNA Polymerase III Transcription Initiation	6.538436e-01	0.185
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	6.538436e-01	0.185
R-HSA-114452	Activation of BH3-only proteins	6.538436e-01	0.185
R-HSA-888590	GABA synthesis, release, reuptake and degradation	6.538436e-01	0.185
R-HSA-1250196	SHC1 events in ERBB2 signaling	6.538436e-01	0.185
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	6.538436e-01	0.185
R-HSA-167172	Transcription of the HIV genome	6.550809e-01	0.184
R-HSA-9018519	Estrogen-dependent gene expression	6.595264e-01	0.181
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	6.620687e-01	0.179
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	6.639069e-01	0.178
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	6.639069e-01	0.178
R-HSA-9833109	Evasion by RSV of host interferon responses	6.639069e-01	0.178
R-HSA-186763	Downstream signal transduction	6.639069e-01	0.178
R-HSA-5619507	Activation of HOX genes during differentiation	6.640329e-01	0.178
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	6.640329e-01	0.178
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	6.644818e-01	0.178
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	6.651549e-01	0.177
R-HSA-597592	Post-translational protein modification	6.654478e-01	0.177
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	6.689424e-01	0.175
R-HSA-75105	Fatty acyl-CoA biosynthesis	6.689424e-01	0.175
R-HSA-69202	Cyclin E associated events during G1/S transition	6.689424e-01	0.175
R-HSA-5696398	Nucleotide Excision Repair	6.696593e-01	0.174
R-HSA-69190	DNA strand elongation	6.736782e-01	0.172
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	6.736782e-01	0.172
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	6.758477e-01	0.170
R-HSA-9678108	SARS-CoV-1 Infection	6.758477e-01	0.170
R-HSA-5578749	Transcriptional regulation by small RNAs	6.823505e-01	0.166
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	6.823505e-01	0.166
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	6.823505e-01	0.166
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	6.823505e-01	0.166
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	6.831660e-01	0.165
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	6.831660e-01	0.165
R-HSA-176187	Activation of ATR in response to replication stress	6.831660e-01	0.165
R-HSA-9930044	Nuclear RNA decay	6.831660e-01	0.165
R-HSA-397795	G-protein beta:gamma signalling	6.831660e-01	0.165
R-HSA-5654726	Negative regulation of FGFR1 signaling	6.831660e-01	0.165
R-HSA-5675482	Regulation of necroptotic cell death	6.831660e-01	0.165
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	6.831660e-01	0.165
R-HSA-69052	Switching of origins to a post-replicative state	6.888865e-01	0.162
R-HSA-5693537	Resolution of D-Loop Structures	6.923785e-01	0.160
R-HSA-1482788	Acyl chain remodelling of PC	6.923785e-01	0.160
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	6.923785e-01	0.160
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	6.923785e-01	0.160
R-HSA-1226099	Signaling by FGFR in disease	6.953116e-01	0.158
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	7.013237e-01	0.154
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	7.013237e-01	0.154
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	7.013237e-01	0.154
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	7.013237e-01	0.154
R-HSA-1971475	Glycosaminoglycan-protein linkage region biosynthesis	7.013237e-01	0.154
R-HSA-5654727	Negative regulation of FGFR2 signaling	7.013237e-01	0.154
R-HSA-3000171	Non-integrin membrane-ECM interactions	7.016267e-01	0.154
R-HSA-9748784	Drug ADME	7.019176e-01	0.154
R-HSA-9020591	Interleukin-12 signaling	7.078328e-01	0.150
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	7.100093e-01	0.149
R-HSA-381042	PERK regulates gene expression	7.100093e-01	0.149
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	7.100093e-01	0.149
R-HSA-1482839	Acyl chain remodelling of PE	7.100093e-01	0.149
R-HSA-1912422	Pre-NOTCH Expression and Processing	7.121884e-01	0.147
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	7.139308e-01	0.146
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	7.171965e-01	0.144
R-HSA-9855142	Cellular responses to mechanical stimuli	7.171965e-01	0.144
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	7.184429e-01	0.144
R-HSA-111933	Calmodulin induced events	7.184429e-01	0.144
R-HSA-111997	CaM pathway	7.184429e-01	0.144
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	7.184429e-01	0.144
R-HSA-416482	G alpha (12/13) signalling events	7.199218e-01	0.143
R-HSA-4086400	PCP/CE pathway	7.199218e-01	0.143
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	7.221370e-01	0.141
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	7.266316e-01	0.139
R-HSA-933541	TRAF6 mediated IRF7 activation	7.266316e-01	0.139
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	7.266316e-01	0.139
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	7.266316e-01	0.139
R-HSA-419037	NCAM1 interactions	7.266316e-01	0.139
R-HSA-5689896	Ovarian tumor domain proteases	7.266316e-01	0.139
R-HSA-5628897	TP53 Regulates Metabolic Genes	7.270101e-01	0.138
R-HSA-9856651	MITF-M-dependent gene expression	7.286551e-01	0.137
R-HSA-5654738	Signaling by FGFR2	7.315872e-01	0.136
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	7.315872e-01	0.136
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	7.345827e-01	0.134
R-HSA-5213460	RIPK1-mediated regulated necrosis	7.345827e-01	0.134
R-HSA-69541	Stabilization of p53	7.423031e-01	0.129
R-HSA-71336	Pentose phosphate pathway	7.423031e-01	0.129
R-HSA-9648002	RAS processing	7.423031e-01	0.129
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	7.428377e-01	0.129
R-HSA-9711123	Cellular response to chemical stress	7.438065e-01	0.129
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	7.483102e-01	0.126
R-HSA-9707564	Cytoprotection by HMOX1	7.483102e-01	0.126
R-HSA-168273	Influenza Viral RNA Transcription and Replication	7.492252e-01	0.125
R-HSA-9646399	Aggrephagy	7.497993e-01	0.125
R-HSA-8941858	Regulation of RUNX3 expression and activity	7.497993e-01	0.125
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	7.536825e-01	0.123
R-HSA-9694548	Maturation of spike protein	7.570779e-01	0.121
R-HSA-9610379	HCMV Late Events	7.571122e-01	0.121
R-HSA-5674135	MAP2K and MAPK activation	7.641452e-01	0.117
R-HSA-9656223	Signaling by RAF1 mutants	7.641452e-01	0.117
R-HSA-9932298	Degradation of CRY and PER proteins	7.641452e-01	0.117
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	7.641452e-01	0.117
R-HSA-9683701	Translation of Structural Proteins	7.641452e-01	0.117
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	7.710073e-01	0.113
R-HSA-111996	Ca-dependent events	7.710073e-01	0.113
R-HSA-165159	MTOR signalling	7.710073e-01	0.113
R-HSA-379716	Cytosolic tRNA aminoacylation	7.710073e-01	0.113
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	7.776702e-01	0.109
R-HSA-8854214	TBC/RABGAPs	7.776702e-01	0.109
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	7.776702e-01	0.109
R-HSA-5654743	Signaling by FGFR4	7.776702e-01	0.109
R-HSA-948021	Transport to the Golgi and subsequent modification	7.788444e-01	0.109
R-HSA-9645723	Diseases of programmed cell death	7.790825e-01	0.108
R-HSA-69206	G1/S Transition	7.803664e-01	0.108
R-HSA-190828	Gap junction trafficking	7.841396e-01	0.106
R-HSA-5683826	Surfactant metabolism	7.841396e-01	0.106
R-HSA-3928662	EPHB-mediated forward signaling	7.841396e-01	0.106
R-HSA-375280	Amine ligand-binding receptors	7.841396e-01	0.106
R-HSA-373752	Netrin-1 signaling	7.841396e-01	0.106
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	7.841396e-01	0.106
R-HSA-73884	Base Excision Repair	7.885836e-01	0.103
R-HSA-202424	Downstream TCR signaling	7.885836e-01	0.103
R-HSA-1489509	DAG and IP3 signaling	7.904211e-01	0.102
R-HSA-5654741	Signaling by FGFR3	7.904211e-01	0.102
R-HSA-187037	Signaling by NTRK1 (TRKA)	7.922816e-01	0.101
R-HSA-8986944	Transcriptional Regulation by MECP2	7.931980e-01	0.101
R-HSA-72165	mRNA Splicing - Minor Pathway	7.965202e-01	0.099
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	7.965202e-01	0.099
R-HSA-2299718	Condensation of Prophase Chromosomes	7.965202e-01	0.099
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	7.965202e-01	0.099
R-HSA-9649948	Signaling downstream of RAS mutants	7.965202e-01	0.099
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	7.965202e-01	0.099
R-HSA-6802949	Signaling by RAS mutants	7.965202e-01	0.099
R-HSA-9675135	Diseases of DNA repair	7.965202e-01	0.099
R-HSA-9861718	Regulation of pyruvate metabolism	7.965202e-01	0.099
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	7.965202e-01	0.099
R-HSA-2682334	EPH-Ephrin signaling	8.021609e-01	0.096
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	8.021609e-01	0.096
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	8.024422e-01	0.096
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	8.024422e-01	0.096
R-HSA-1483191	Synthesis of PC	8.024422e-01	0.096
R-HSA-1474165	Reproduction	8.036547e-01	0.095
R-HSA-1280215	Cytokine Signaling in Immune system	8.042948e-01	0.095
R-HSA-68867	Assembly of the pre-replicative complex	8.065118e-01	0.093
R-HSA-5621481	C-type lectin receptors (CLRs)	8.102598e-01	0.091
R-HSA-397014	Muscle contraction	8.128425e-01	0.090
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	8.137752e-01	0.089
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	8.137752e-01	0.089
R-HSA-69563	p53-Dependent G1 DNA Damage Response	8.137752e-01	0.089
R-HSA-73893	DNA Damage Bypass	8.137752e-01	0.089
R-HSA-212436	Generic Transcription Pathway	8.143232e-01	0.089
R-HSA-9730414	MITF-M-regulated melanocyte development	8.157157e-01	0.088
R-HSA-72689	Formation of a pool of free 40S subunits	8.190583e-01	0.087
R-HSA-9748787	Azathioprine ADME	8.191960e-01	0.087
R-HSA-1169091	Activation of NF-kappaB in B cells	8.244593e-01	0.084
R-HSA-912446	Meiotic recombination	8.244593e-01	0.084
R-HSA-2514856	The phototransduction cascade	8.244593e-01	0.084
R-HSA-3858494	Beta-catenin independent WNT signaling	8.281694e-01	0.082
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	8.295697e-01	0.081
R-HSA-112382	Formation of RNA Pol II elongation complex	8.295697e-01	0.081
R-HSA-68949	Orc1 removal from chromatin	8.295697e-01	0.081
R-HSA-190236	Signaling by FGFR	8.308716e-01	0.080
R-HSA-6798695	Neutrophil degranulation	8.328950e-01	0.079
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	8.345317e-01	0.079
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	8.345317e-01	0.079
R-HSA-75955	RNA Polymerase II Transcription Elongation	8.345317e-01	0.079
R-HSA-9639288	Amino acids regulate mTORC1	8.345317e-01	0.079
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	8.393495e-01	0.076
R-HSA-983169	Class I MHC mediated antigen processing & presentation	8.411106e-01	0.075
R-HSA-416476	G alpha (q) signalling events	8.419124e-01	0.075
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	8.440273e-01	0.074
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	8.440273e-01	0.074
R-HSA-9012852	Signaling by NOTCH3	8.440273e-01	0.074
R-HSA-1483255	PI Metabolism	8.455410e-01	0.073
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	8.485691e-01	0.071
R-HSA-193648	NRAGE signals death through JNK	8.485691e-01	0.071
R-HSA-5654736	Signaling by FGFR1	8.485691e-01	0.071
R-HSA-9675108	Nervous system development	8.491219e-01	0.071
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	8.500181e-01	0.071
R-HSA-422475	Axon guidance	8.516194e-01	0.070
R-HSA-111885	Opioid Signalling	8.524345e-01	0.069
R-HSA-9860931	Response of endothelial cells to shear stress	8.524345e-01	0.069
R-HSA-6782135	Dual incision in TC-NER	8.572608e-01	0.067
R-HSA-8868773	rRNA processing in the nucleus and cytosol	8.586159e-01	0.066
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	8.590467e-01	0.066
R-HSA-180786	Extension of Telomeres	8.614180e-01	0.065
R-HSA-429914	Deadenylation-dependent mRNA decay	8.614180e-01	0.065
R-HSA-4085001	Sialic acid metabolism	8.614180e-01	0.065
R-HSA-186712	Regulation of beta-cell development	8.614180e-01	0.065
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	8.614180e-01	0.065
R-HSA-352230	Amino acid transport across the plasma membrane	8.614180e-01	0.065
R-HSA-162582	Signal Transduction	8.614368e-01	0.065
R-HSA-69239	Synthesis of DNA	8.653872e-01	0.063
R-HSA-211000	Gene Silencing by RNA	8.653872e-01	0.063
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	8.654545e-01	0.063
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	8.654545e-01	0.063
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	8.654545e-01	0.063
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	8.654545e-01	0.063
R-HSA-2644603	Signaling by NOTCH1 in Cancer	8.654545e-01	0.063
R-HSA-379724	tRNA Aminoacylation	8.654545e-01	0.063
R-HSA-1227986	Signaling by ERBB2	8.654545e-01	0.063
R-HSA-168898	Toll-like Receptor Cascades	8.659631e-01	0.063
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	8.667830e-01	0.062
R-HSA-166520	Signaling by NTRKs	8.667830e-01	0.062
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	8.683385e-01	0.061
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	8.684585e-01	0.061
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	8.684585e-01	0.061
R-HSA-2672351	Stimuli-sensing channels	8.684585e-01	0.061
R-HSA-9793380	Formation of paraxial mesoderm	8.693736e-01	0.061
R-HSA-450294	MAP kinase activation	8.693736e-01	0.061
R-HSA-69002	DNA Replication Pre-Initiation	8.714654e-01	0.060
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	8.731788e-01	0.059
R-HSA-1268020	Mitochondrial protein import	8.731788e-01	0.059
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	8.731788e-01	0.059
R-HSA-375165	NCAM signaling for neurite out-growth	8.731788e-01	0.059
R-HSA-186797	Signaling by PDGF	8.731788e-01	0.059
R-HSA-202403	TCR signaling	8.744090e-01	0.058
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	8.744090e-01	0.058
R-HSA-166166	MyD88-independent TLR4 cascade	8.744090e-01	0.058
R-HSA-8939211	ESR-mediated signaling	8.746217e-01	0.058
R-HSA-69615	G1/S DNA Damage Checkpoints	8.768734e-01	0.057
R-HSA-8848021	Signaling by PTK6	8.768734e-01	0.057
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	8.768734e-01	0.057
R-HSA-936837	Ion transport by P-type ATPases	8.804606e-01	0.055
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	8.818768e-01	0.055
R-HSA-1234174	Cellular response to hypoxia	8.839434e-01	0.054
R-HSA-166663	Initial triggering of complement	8.882171e-01	0.051
R-HSA-5685942	HDR through Homologous Recombination (HRR)	8.906083e-01	0.050
R-HSA-9958863	SLC-mediated transport of amino acids	8.906083e-01	0.050
R-HSA-909733	Interferon alpha/beta signaling	8.933360e-01	0.049
R-HSA-9609646	HCMV Infection	8.992786e-01	0.046
R-HSA-204005	COPII-mediated vesicle transport	8.998963e-01	0.046
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	8.998963e-01	0.046
R-HSA-9840310	Glycosphingolipid catabolism	8.998963e-01	0.046
R-HSA-448424	Interleukin-17 signaling	8.998963e-01	0.046
R-HSA-453276	Regulation of mitotic cell cycle	9.028139e-01	0.044
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	9.028139e-01	0.044
R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activ...	9.028139e-01	0.044
R-HSA-446203	Asparagine N-linked glycosylation	9.051939e-01	0.043
R-HSA-195721	Signaling by WNT	9.067387e-01	0.043
R-HSA-4086398	Ca2+ pathway	9.083972e-01	0.042
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	9.083972e-01	0.042
R-HSA-109582	Hemostasis	9.087563e-01	0.042
R-HSA-5619102	SLC transporter disorders	9.094686e-01	0.041
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	9.104629e-01	0.041
R-HSA-9013694	Signaling by NOTCH4	9.110676e-01	0.040
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	9.136603e-01	0.039
R-HSA-71403	Citric acid cycle (TCA cycle)	9.136603e-01	0.039
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	9.136603e-01	0.039
R-HSA-977606	Regulation of Complement cascade	9.158155e-01	0.038
R-HSA-1980143	Signaling by NOTCH1	9.161775e-01	0.038
R-HSA-5689603	UCH proteinases	9.161775e-01	0.038
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	9.167020e-01	0.038
R-HSA-72306	tRNA processing	9.167020e-01	0.038
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	9.178010e-01	0.037
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	9.178010e-01	0.037
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	9.178010e-01	0.037
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	9.209945e-01	0.036
R-HSA-216083	Integrin cell surface interactions	9.209945e-01	0.036
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	9.234057e-01	0.035
R-HSA-199418	Negative regulation of the PI3K/AKT network	9.270855e-01	0.033
R-HSA-9705683	SARS-CoV-2-host interactions	9.340456e-01	0.030
R-HSA-9006931	Signaling by Nuclear Receptors	9.342346e-01	0.030
R-HSA-201681	TCF dependent signaling in response to WNT	9.367218e-01	0.028
R-HSA-112315	Transmission across Chemical Synapses	9.384320e-01	0.028
R-HSA-72312	rRNA processing	9.389884e-01	0.027
R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	9.394723e-01	0.027
R-HSA-438064	Post NMDA receptor activation events	9.412383e-01	0.026
R-HSA-983712	Ion channel transport	9.443765e-01	0.025
R-HSA-9664407	Parasite infection	9.454923e-01	0.024
R-HSA-9664422	FCGR3A-mediated phagocytosis	9.454923e-01	0.024
R-HSA-9664417	Leishmania phagocytosis	9.454923e-01	0.024
R-HSA-112310	Neurotransmitter release cycle	9.462338e-01	0.024
R-HSA-156580	Phase II - Conjugation of compounds	9.468354e-01	0.024
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	9.478029e-01	0.023
R-HSA-112316	Neuronal System	9.514534e-01	0.022
R-HSA-2871837	FCERI mediated NF-kB activation	9.517768e-01	0.021
R-HSA-9609690	HCMV Early Events	9.522186e-01	0.021
R-HSA-2029481	FCGR activation	9.522414e-01	0.021
R-HSA-166658	Complement cascade	9.529479e-01	0.021
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	9.536355e-01	0.021
R-HSA-9837999	Mitochondrial protein degradation	9.536355e-01	0.021
R-HSA-1474290	Collagen formation	9.536355e-01	0.021
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	9.549890e-01	0.020
R-HSA-1483257	Phospholipid metabolism	9.550446e-01	0.020
R-HSA-392499	Metabolism of proteins	9.555847e-01	0.020
R-HSA-428157	Sphingolipid metabolism	9.571755e-01	0.019
R-HSA-376176	Signaling by ROBO receptors	9.590202e-01	0.018
R-HSA-1483206	Glycerophospholipid biosynthesis	9.590202e-01	0.018
R-HSA-975871	MyD88 cascade initiated on plasma membrane	9.600201e-01	0.018
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	9.600201e-01	0.018
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	9.600201e-01	0.018
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	9.604169e-01	0.018
R-HSA-9614085	FOXO-mediated transcription	9.611876e-01	0.017
R-HSA-193704	p75 NTR receptor-mediated signalling	9.611876e-01	0.017
R-HSA-69306	DNA Replication	9.613864e-01	0.017
R-HSA-388841	Regulation of T cell activation by CD28 family	9.622006e-01	0.017
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	9.622219e-01	0.017
R-HSA-5610787	Hedgehog 'off' state	9.623211e-01	0.017
R-HSA-382556	ABC-family proteins mediated transport	9.623211e-01	0.017
R-HSA-9009391	Extra-nuclear estrogen signaling	9.634215e-01	0.016
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	9.644899e-01	0.016
R-HSA-9937383	Mitochondrial ribosome-associated quality control	9.655271e-01	0.015
R-HSA-192823	Viral mRNA Translation	9.655271e-01	0.015
R-HSA-9711097	Cellular response to starvation	9.659023e-01	0.015
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	9.665341e-01	0.015
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	9.665341e-01	0.015
R-HSA-1236975	Antigen processing-Cross presentation	9.711455e-01	0.013
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	9.711455e-01	0.013
R-HSA-1280218	Adaptive Immune System	9.715948e-01	0.013
R-HSA-975155	MyD88 dependent cascade initiated on endosome	9.719887e-01	0.012
R-HSA-8951664	Neddylation	9.731873e-01	0.012
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	9.743735e-01	0.011
R-HSA-927802	Nonsense-Mediated Decay (NMD)	9.743735e-01	0.011
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	9.751226e-01	0.011
R-HSA-9909648	Regulation of PD-L1(CD274) expression	9.766049e-01	0.010
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	9.772411e-01	0.010
R-HSA-2029485	Role of phospholipids in phagocytosis	9.779065e-01	0.010
R-HSA-72766	Translation	9.789339e-01	0.009
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	9.803795e-01	0.009
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	9.803795e-01	0.009
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	9.820512e-01	0.008
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	9.820512e-01	0.008
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	9.825762e-01	0.008
R-HSA-1660662	Glycosphingolipid metabolism	9.825762e-01	0.008
R-HSA-157118	Signaling by NOTCH	9.826280e-01	0.008
R-HSA-6809371	Formation of the cornified envelope	9.830859e-01	0.007
R-HSA-449147	Signaling by Interleukins	9.834964e-01	0.007
R-HSA-9664323	FCGR3A-mediated IL10 synthesis	9.845274e-01	0.007
R-HSA-5619115	Disorders of transmembrane transporters	9.852283e-01	0.006
R-HSA-5576891	Cardiac conduction	9.870530e-01	0.006
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	9.870530e-01	0.006
R-HSA-389948	Co-inhibition by PD-1	9.885644e-01	0.005
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	9.894178e-01	0.005
R-HSA-5663205	Infectious disease	9.895408e-01	0.005
R-HSA-5368287	Mitochondrial translation	9.897922e-01	0.004
R-HSA-9948299	Ribosome-associated quality control	9.897922e-01	0.004
R-HSA-5358351	Signaling by Hedgehog	9.897922e-01	0.004
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	9.906631e-01	0.004
R-HSA-8957322	Metabolism of steroids	9.910959e-01	0.004
R-HSA-8856828	Clathrin-mediated endocytosis	9.914598e-01	0.004
R-HSA-1474244	Extracellular matrix organization	9.923756e-01	0.003
R-HSA-2187338	Visual phototransduction	9.924175e-01	0.003
R-HSA-9758941	Gastrulation	9.928554e-01	0.003
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	9.930648e-01	0.003
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	9.934654e-01	0.003
R-HSA-9609507	Protein localization	9.936569e-01	0.003
R-HSA-1428517	Aerobic respiration and respiratory electron transport	9.939023e-01	0.003
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L...	9.943687e-01	0.002
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	9.945338e-01	0.002
R-HSA-877300	Interferon gamma signaling	9.946941e-01	0.002
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	9.949916e-01	0.002
R-HSA-15869	Metabolism of nucleotides	9.956503e-01	0.002
R-HSA-202733	Cell surface interactions at the vascular wall	9.957636e-01	0.002
R-HSA-211897	Cytochrome P450 - arranged by substrate type	9.958185e-01	0.002
R-HSA-418555	G alpha (s) signalling events	9.963971e-01	0.002
R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	9.966054e-01	0.001
R-HSA-9664433	Leishmania parasite growth and survival	9.966054e-01	0.001
R-HSA-611105	Respiratory electron transport	9.970753e-01	0.001
R-HSA-375276	Peptide ligand-binding receptors	9.976958e-01	0.001
R-HSA-168256	Immune System	9.978577e-01	0.001
R-HSA-9734767	Developmental Cell Lineages	9.978776e-01	0.001
R-HSA-1266738	Developmental Biology	9.978843e-01	0.001
R-HSA-168249	Innate Immune System	9.979505e-01	0.001
R-HSA-1630316	Glycosaminoglycan metabolism	9.981299e-01	0.001
R-HSA-9824443	Parasitic Infection Pathways	9.986910e-01	0.001
R-HSA-9658195	Leishmania infection	9.986910e-01	0.001
R-HSA-6805567	Keratinization	9.987685e-01	0.001
R-HSA-5673001	RAF/MAP kinase cascade	9.989452e-01	0.000
R-HSA-5684996	MAPK1/MAPK3 signaling	9.991273e-01	0.000
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	9.993806e-01	0.000
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	9.993988e-01	0.000
R-HSA-388396	GPCR downstream signalling	9.995064e-01	0.000
R-HSA-1643685	Disease	9.995647e-01	0.000
R-HSA-9824439	Bacterial Infection Pathways	9.995700e-01	0.000
R-HSA-425407	SLC-mediated transmembrane transport	9.996407e-01	0.000
R-HSA-211859	Biological oxidations	9.996620e-01	0.000
R-HSA-5683057	MAPK family signaling cascades	9.997836e-01	0.000
R-HSA-211945	Phase I - Functionalization of compounds	9.998572e-01	0.000
R-HSA-372790	Signaling by GPCR	9.999083e-01	0.000
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	9.999429e-01	0.000
R-HSA-418594	G alpha (i) signalling events	9.999603e-01	0.000
R-HSA-8978868	Fatty acid metabolism	9.999603e-01	0.000
R-HSA-382551	Transport of small molecules	9.999795e-01	0.000
R-HSA-196854	Metabolism of vitamins and cofactors	9.999892e-01	0.000
R-HSA-500792	GPCR ligand binding	9.999998e-01	0.000
R-HSA-556833	Metabolism of lipids	9.999999e-01	0.000
R-HSA-71291	Metabolism of amino acids and derivatives	9.999999e-01	0.000
R-HSA-1430728	Metabolism	1.000000e+00	-0.000
R-HSA-9709957	Sensory Perception	1.000000e+00	-0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
COT	0.902	0.259	2	0.860
CLK3	0.899	0.388	1	0.893
CDC7	0.888	0.100	1	0.849
KIS	0.888	0.337	1	0.815
MOS	0.887	0.176	1	0.875
DSTYK	0.883	0.098	2	0.877
MTOR	0.883	0.056	1	0.844
NLK	0.881	0.216	1	0.910
PIM3	0.881	0.092	-3	0.842
IKKB	0.881	-0.010	-2	0.773
RAF1	0.880	0.004	1	0.847
NDR2	0.880	0.074	-3	0.844
CAMK2G	0.880	0.063	2	0.826
PRPK	0.880	-0.102	-1	0.863
SRPK1	0.878	0.197	-3	0.759
GCN2	0.878	-0.101	2	0.781
GRK1	0.877	0.177	-2	0.829
TBK1	0.877	-0.034	1	0.758
HIPK4	0.876	0.204	1	0.856
BMPR1B	0.875	0.287	1	0.806
CAMK1B	0.875	0.009	-3	0.876
ERK5	0.875	0.112	1	0.846
BMPR2	0.875	-0.038	-2	0.926
PDHK4	0.875	-0.204	1	0.865
CDKL1	0.875	0.075	-3	0.812
IKKE	0.874	-0.041	1	0.756
ATR	0.873	-0.015	1	0.816
NEK6	0.873	0.020	-2	0.901
FAM20C	0.873	0.196	2	0.662
IKKA	0.873	0.070	-2	0.767
GRK6	0.872	0.105	1	0.842
PIM1	0.872	0.124	-3	0.795
PRKD1	0.871	0.075	-3	0.819
CDK8	0.871	0.253	1	0.796
RSK2	0.871	0.083	-3	0.779
TGFBR2	0.871	0.031	-2	0.870
GRK5	0.870	-0.053	-3	0.879
PKN3	0.870	0.010	-3	0.830
CDK1	0.870	0.312	1	0.785
TGFBR1	0.870	0.208	-2	0.872
JNK2	0.869	0.343	1	0.771
SKMLCK	0.869	0.050	-2	0.872
NEK7	0.869	-0.091	-3	0.846
CAMK2B	0.869	0.151	2	0.819
ICK	0.869	0.139	-3	0.843
MST4	0.868	0.024	2	0.839
ULK2	0.868	-0.198	2	0.754
CLK2	0.868	0.296	-3	0.760
PDHK1	0.868	-0.214	1	0.842
DYRK2	0.868	0.269	1	0.818
NDR1	0.868	-0.005	-3	0.838
PRKD2	0.868	0.083	-3	0.775
SRPK2	0.867	0.153	-3	0.684
NUAK2	0.867	0.017	-3	0.849
GRK7	0.867	0.192	1	0.789
CDKL5	0.867	0.063	-3	0.800
NIK	0.867	-0.066	-3	0.891
JNK3	0.866	0.315	1	0.799
LATS2	0.866	0.027	-5	0.762
ALK4	0.866	0.144	-2	0.894
CDK19	0.866	0.251	1	0.766
CAMK2D	0.866	0.017	-3	0.841
CAMLCK	0.865	-0.017	-2	0.870
CHAK2	0.864	-0.040	-1	0.845
RIPK3	0.864	-0.116	3	0.765
MLK1	0.864	-0.115	2	0.784
P90RSK	0.864	0.020	-3	0.777
MARK4	0.864	-0.020	4	0.881
DAPK2	0.864	-0.025	-3	0.873
ATM	0.864	0.024	1	0.756
WNK1	0.864	-0.065	-2	0.883
GRK4	0.863	-0.022	-2	0.867
SRPK3	0.863	0.128	-3	0.737
MAPKAPK2	0.862	0.066	-3	0.735
PLK1	0.862	0.070	-2	0.873
LATS1	0.862	0.123	-3	0.849
AMPKA1	0.862	-0.006	-3	0.858
CAMK2A	0.862	0.112	2	0.824
CLK4	0.862	0.178	-3	0.777
PKCD	0.862	0.017	2	0.762
ALK2	0.862	0.191	-2	0.880
CDK7	0.862	0.216	1	0.812
ACVR2B	0.862	0.173	-2	0.869
BCKDK	0.861	-0.150	-1	0.826
CDK5	0.861	0.262	1	0.823
PKN2	0.861	-0.031	-3	0.844
HUNK	0.861	-0.162	2	0.771
P70S6KB	0.861	0.011	-3	0.805
HIPK2	0.861	0.296	1	0.754
ACVR2A	0.861	0.154	-2	0.859
CDK18	0.861	0.275	1	0.755
P38B	0.860	0.296	1	0.769
AURC	0.860	0.072	-2	0.669
ULK1	0.859	-0.214	-3	0.825
P38G	0.859	0.298	1	0.709
RSK3	0.859	-0.003	-3	0.774
BMPR1A	0.859	0.241	1	0.784
ANKRD3	0.859	-0.111	1	0.847
PKACG	0.858	0.006	-2	0.756
P38A	0.858	0.260	1	0.823
MAPKAPK3	0.858	-0.033	-3	0.776
CLK1	0.858	0.183	-3	0.757
DLK	0.858	-0.154	1	0.823
CDK13	0.858	0.216	1	0.793
ERK1	0.858	0.264	1	0.764
MASTL	0.857	-0.291	-2	0.843
PLK3	0.857	0.056	2	0.759
HIPK1	0.856	0.254	1	0.830
TSSK2	0.856	-0.038	-5	0.844
CDK17	0.856	0.263	1	0.716
DNAPK	0.856	0.073	1	0.731
AMPKA2	0.856	-0.008	-3	0.825
NEK9	0.855	-0.202	2	0.810
PKR	0.855	-0.003	1	0.824
CDK3	0.855	0.278	1	0.732
RSK4	0.855	0.075	-3	0.747
TSSK1	0.854	-0.013	-3	0.873
DYRK4	0.854	0.281	1	0.768
WNK3	0.854	-0.307	1	0.808
MLK2	0.854	-0.173	2	0.797
MLK3	0.853	-0.060	2	0.711
CDK2	0.853	0.174	1	0.843
PKACB	0.853	0.088	-2	0.686
ERK2	0.853	0.221	1	0.801
PRKX	0.852	0.133	-3	0.684
MSK2	0.852	-0.026	-3	0.748
MEK1	0.852	-0.141	2	0.816
P38D	0.852	0.308	1	0.716
NIM1	0.851	-0.121	3	0.787
YSK4	0.851	-0.097	1	0.779
PAK1	0.851	-0.036	-2	0.792
RIPK1	0.851	-0.256	1	0.801
MSK1	0.851	0.040	-3	0.752
TLK2	0.850	-0.012	1	0.781
CDK12	0.849	0.209	1	0.772
CAMK4	0.849	-0.124	-3	0.830
TTBK2	0.849	-0.228	2	0.661
QSK	0.849	-0.010	4	0.855
DYRK1A	0.849	0.185	1	0.849
NUAK1	0.849	-0.047	-3	0.800
PRKD3	0.848	-0.012	-3	0.754
MLK4	0.848	-0.070	2	0.689
AURB	0.848	0.021	-2	0.666
DYRK1B	0.848	0.235	1	0.798
PKCB	0.848	-0.033	2	0.707
GRK2	0.848	-0.006	-2	0.745
BRAF	0.847	-0.008	-4	0.858
CDK9	0.847	0.177	1	0.798
VRK2	0.847	-0.250	1	0.865
CDK16	0.847	0.269	1	0.729
IRE1	0.847	-0.177	1	0.769
AURA	0.847	0.029	-2	0.639
CDK14	0.846	0.237	1	0.797
PRP4	0.846	0.108	-3	0.742
SIK	0.846	-0.027	-3	0.772
PKCA	0.846	-0.038	2	0.699
MNK2	0.845	-0.050	-2	0.803
GSK3A	0.845	0.166	4	0.530
PAK3	0.845	-0.110	-2	0.792
PKCG	0.845	-0.066	2	0.699
MYLK4	0.845	-0.022	-2	0.783
CHK1	0.845	-0.033	-3	0.830
MELK	0.845	-0.094	-3	0.807
BRSK1	0.845	-0.052	-3	0.797
IRE2	0.845	-0.125	2	0.711
HIPK3	0.845	0.185	1	0.823
PIM2	0.844	0.042	-3	0.755
CK2A2	0.844	0.178	1	0.730
SMG1	0.844	-0.095	1	0.763
QIK	0.844	-0.146	-3	0.838
MARK3	0.844	-0.005	4	0.821
MARK2	0.844	-0.018	4	0.785
JNK1	0.844	0.257	1	0.767
AKT2	0.843	0.036	-3	0.699
PAK6	0.843	0.006	-2	0.713
CDK10	0.843	0.243	1	0.786
SGK3	0.842	0.010	-3	0.762
DRAK1	0.842	-0.066	1	0.803
PASK	0.842	0.060	-3	0.857
PERK	0.842	-0.118	-2	0.893
PHKG1	0.842	-0.116	-3	0.829
NEK2	0.842	-0.184	2	0.785
MNK1	0.842	-0.041	-2	0.816
PKCZ	0.841	-0.102	2	0.749
DYRK3	0.841	0.177	1	0.823
PINK1	0.841	-0.099	1	0.858
PKG2	0.841	-0.007	-2	0.686
PAK2	0.841	-0.108	-2	0.778
PKCH	0.841	-0.097	2	0.685
MEKK3	0.840	-0.138	1	0.800
CK1E	0.840	0.024	-3	0.601
TLK1	0.840	-0.056	-2	0.882
TAO3	0.840	-0.000	1	0.804
CHAK1	0.839	-0.221	2	0.744
DCAMKL1	0.839	-0.030	-3	0.791
MEKK1	0.839	-0.171	1	0.795
BRSK2	0.839	-0.125	-3	0.818
GAK	0.839	0.099	1	0.848
GSK3B	0.838	0.072	4	0.522
PLK4	0.838	-0.129	2	0.586
HRI	0.838	-0.195	-2	0.896
MST3	0.837	-0.032	2	0.807
CAMK1G	0.837	-0.072	-3	0.772
MEKK2	0.837	-0.128	2	0.774
MARK1	0.837	-0.066	4	0.838
PLK2	0.837	0.109	-3	0.850
ZAK	0.836	-0.182	1	0.769
MPSK1	0.836	0.035	1	0.785
MEK5	0.836	-0.311	2	0.796
NEK5	0.836	-0.150	1	0.811
CK1D	0.836	0.049	-3	0.550
GRK3	0.835	0.003	-2	0.702
PKACA	0.835	0.042	-2	0.632
CK2A1	0.833	0.150	1	0.712
SMMLCK	0.833	-0.061	-3	0.827
ERK7	0.833	0.069	2	0.527
MAK	0.833	0.229	-2	0.758
MAPKAPK5	0.833	-0.169	-3	0.716
GCK	0.832	0.037	1	0.825
WNK4	0.831	-0.206	-2	0.875
SNRK	0.831	-0.287	2	0.646
AKT1	0.831	0.017	-3	0.712
CDK6	0.830	0.212	1	0.776
CK1G1	0.830	-0.023	-3	0.595
DCAMKL2	0.830	-0.082	-3	0.818
MST2	0.830	-0.027	1	0.811
CAMKK1	0.829	-0.170	-2	0.792
P70S6K	0.829	-0.057	-3	0.713
CDK4	0.829	0.214	1	0.760
CAMK1D	0.829	-0.021	-3	0.695
NEK8	0.829	-0.182	2	0.784
CK1A2	0.828	0.015	-3	0.551
LKB1	0.828	-0.093	-3	0.825
DAPK3	0.828	0.006	-3	0.808
SSTK	0.827	-0.082	4	0.838
TAO2	0.827	-0.136	2	0.826
IRAK4	0.827	-0.236	1	0.766
NEK11	0.826	-0.217	1	0.815
PKCT	0.826	-0.106	2	0.697
PDK1	0.826	-0.108	1	0.819
TAK1	0.825	-0.059	1	0.820
CAMKK2	0.825	-0.156	-2	0.783
TNIK	0.825	-0.004	3	0.871
MINK	0.824	-0.052	1	0.795
MOK	0.824	0.176	1	0.813
PDHK3_TYR	0.824	0.294	4	0.930
PHKG2	0.823	-0.131	-3	0.809
HPK1	0.823	-0.013	1	0.816
PKCI	0.823	-0.102	2	0.709
EEF2K	0.822	-0.071	3	0.841
PAK5	0.822	-0.060	-2	0.648
DAPK1	0.822	-0.006	-3	0.792
HGK	0.822	-0.083	3	0.868
SGK1	0.822	0.045	-3	0.615
TTBK1	0.820	-0.262	2	0.577
PKCE	0.820	-0.044	2	0.683
KHS2	0.820	0.049	1	0.817
NEK4	0.820	-0.199	1	0.781
PAK4	0.819	-0.047	-2	0.656
MRCKA	0.819	0.017	-3	0.761
KHS1	0.818	0.003	1	0.797
AKT3	0.818	0.028	-3	0.631
MST1	0.818	-0.101	1	0.793
MAP3K15	0.818	-0.187	1	0.763
ROCK2	0.817	0.025	-3	0.788
LRRK2	0.817	-0.222	2	0.819
PDHK4_TYR	0.817	0.175	2	0.876
MRCKB	0.816	0.005	-3	0.747
LOK	0.816	-0.113	-2	0.790
IRAK1	0.816	-0.389	-1	0.747
MAP2K6_TYR	0.816	0.152	-1	0.892
SLK	0.816	-0.095	-2	0.735
CHK2	0.815	-0.040	-3	0.644
MEKK6	0.815	-0.237	1	0.777
SBK	0.815	0.040	-3	0.581
NEK1	0.815	-0.196	1	0.783
MAP2K4_TYR	0.814	0.072	-1	0.889
PKN1	0.814	-0.074	-3	0.729
VRK1	0.814	-0.252	2	0.802
PBK	0.813	-0.013	1	0.769
BMPR2_TYR	0.813	0.096	-1	0.882
CAMK1A	0.812	-0.038	-3	0.667
TTK	0.812	0.022	-2	0.885
PDHK1_TYR	0.812	0.078	-1	0.908
TESK1_TYR	0.811	-0.059	3	0.890
DMPK1	0.811	0.054	-3	0.772
MEK2	0.809	-0.313	2	0.783
OSR1	0.809	-0.054	2	0.774
BUB1	0.809	-0.002	-5	0.777
YSK1	0.808	-0.168	2	0.782
MAP2K7_TYR	0.808	-0.195	2	0.841
PKMYT1_TYR	0.807	-0.093	3	0.863
STK33	0.806	-0.246	2	0.575
PINK1_TYR	0.804	-0.197	1	0.838
ALPHAK3	0.804	-0.033	-1	0.782
RIPK2	0.803	-0.378	1	0.735
EPHA6	0.803	0.020	-1	0.884
CRIK	0.802	0.010	-3	0.709
LIMK2_TYR	0.802	-0.067	-3	0.890
ROCK1	0.802	-0.008	-3	0.758
BIKE	0.802	0.020	1	0.737
TXK	0.800	0.135	1	0.814
HASPIN	0.800	-0.054	-1	0.690
EPHB4	0.799	-0.017	-1	0.860
RET	0.799	-0.138	1	0.792
NEK3	0.797	-0.272	1	0.745
CK1A	0.797	-0.000	-3	0.462
YES1	0.796	-0.010	-1	0.856
INSRR	0.796	-0.021	3	0.752
PKG1	0.796	-0.077	-2	0.602
CSF1R	0.796	-0.090	3	0.802
MYO3B	0.796	-0.133	2	0.797
ABL2	0.795	-0.020	-1	0.830
MYO3A	0.795	-0.129	1	0.787
ASK1	0.795	-0.239	1	0.753
YANK3	0.795	-0.105	2	0.375
TYK2	0.794	-0.239	1	0.788
EPHA4	0.794	-0.013	2	0.762
MST1R	0.794	-0.194	3	0.817
LIMK1_TYR	0.794	-0.272	2	0.830
FGR	0.794	-0.082	1	0.819
JAK3	0.792	-0.106	1	0.776
JAK2	0.792	-0.204	1	0.785
ROS1	0.792	-0.195	3	0.775
TYRO3	0.792	-0.214	3	0.804
DDR1	0.792	-0.213	4	0.844
BLK	0.791	0.068	-1	0.851
LCK	0.791	0.022	-1	0.839
TAO1	0.791	-0.178	1	0.731
SRMS	0.791	-0.047	1	0.821
FER	0.791	-0.143	1	0.836
HCK	0.789	-0.082	-1	0.836
ABL1	0.789	-0.070	-1	0.822
EPHB2	0.789	-0.022	-1	0.843
EPHB1	0.789	-0.080	1	0.813
KIT	0.789	-0.112	3	0.805
FGFR2	0.788	-0.125	3	0.803
FYN	0.787	0.059	-1	0.814
EPHB3	0.786	-0.090	-1	0.845
NEK10_TYR	0.785	-0.125	1	0.696
AAK1	0.785	0.068	1	0.642
KDR	0.785	-0.125	3	0.766
ITK	0.785	-0.097	-1	0.799
TNK2	0.785	-0.148	3	0.761
FLT3	0.784	-0.172	3	0.799
STLK3	0.784	-0.257	1	0.734
FLT1	0.783	-0.062	-1	0.858
PDGFRB	0.783	-0.244	3	0.809
MET	0.783	-0.113	3	0.788
JAK1	0.782	-0.127	1	0.747
FGFR1	0.782	-0.180	3	0.771
TEC	0.782	-0.084	-1	0.744
BMX	0.781	-0.075	-1	0.721
TEK	0.780	-0.208	3	0.741
MERTK	0.780	-0.134	3	0.784
EPHA7	0.780	-0.083	2	0.757
FGFR3	0.779	-0.117	3	0.775
TNNI3K_TYR	0.779	-0.148	1	0.765
NTRK1	0.778	-0.207	-1	0.837
ERBB2	0.778	-0.168	1	0.762
EPHA3	0.777	-0.148	2	0.731
AXL	0.777	-0.221	3	0.785
TNK1	0.777	-0.228	3	0.788
PTK2	0.777	0.056	-1	0.809
EPHA5	0.777	-0.038	2	0.749
CK1G3	0.776	-0.011	-3	0.414
LYN	0.776	-0.090	3	0.731
BTK	0.775	-0.252	-1	0.762
FRK	0.775	-0.121	-1	0.856
ALK	0.775	-0.218	3	0.715
LTK	0.775	-0.204	3	0.744
PDGFRA	0.774	-0.330	3	0.808
SYK	0.774	0.057	-1	0.796
WEE1_TYR	0.774	-0.186	-1	0.738
INSR	0.774	-0.184	3	0.733
DDR2	0.774	-0.085	3	0.738
FLT4	0.773	-0.204	3	0.768
SRC	0.773	-0.057	-1	0.816
EGFR	0.773	-0.068	1	0.667
EPHA8	0.773	-0.075	-1	0.824
PTK2B	0.773	-0.077	-1	0.788
PTK6	0.772	-0.272	-1	0.724
NTRK2	0.772	-0.256	3	0.760
NTRK3	0.771	-0.180	-1	0.788
EPHA1	0.770	-0.204	3	0.768
MATK	0.770	-0.158	-1	0.756
FGFR4	0.769	-0.091	-1	0.790
CSK	0.765	-0.184	2	0.756
EPHA2	0.764	-0.079	-1	0.794
ERBB4	0.762	-0.050	1	0.689
YANK2	0.760	-0.136	2	0.392
IGF1R	0.760	-0.166	3	0.672
CK1G2	0.756	-0.030	-3	0.511
MUSK	0.752	-0.239	1	0.662
ZAP70	0.747	-0.045	-1	0.705
FES	0.742	-0.212	-1	0.700