Motif 665 (n=201)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYG9 | ARPC4-TTLL3 | S42 | ochoa | Protein ARPC4-TTLL3 | None |
| A4UGR9 | XIRP2 | S1622 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A4UGR9 | XIRP2 | S2222 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6NHT5 | HMX3 | S185 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| A6NKT7 | RGPD3 | S1033 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E9PAV3 | NACA | S2029 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S597 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00562 | PITPNM1 | S373 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O00566 | MPHOSPH10 | S120 | ochoa | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| O14715 | RGPD8 | S1032 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15027 | SEC16A | S561 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15397 | IPO8 | S902 | ochoa | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
| O15516 | CLOCK | S106 | psp | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43175 | PHGDH | S287 | ochoa | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O60216 | RAD21 | S175 | ochoa|psp | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
| O60502 | OGA | S515 | ochoa | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714, ECO:0000269|PubMed:28939839, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}. |
| O60814 | H2BC12 | S56 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O75410 | TACC1 | S576 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94782 | USP1 | S273 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| P07900 | HSP90AA1 | S169 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07910 | HNRNPC | S238 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08172 | CHRM2 | S311 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08238 | HSP90AB1 | S164 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09211 | GSTP1 | S43 | psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P0DJD0 | RGPD1 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD0 | RGPD1 | S1579 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1025 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJD1 | RGPD2 | S1587 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12036 | NEFH | S540 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12270 | TPR | S929 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P15822 | HIVEP1 | S523 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18206 | VCL | S600 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19801 | AOC1 | S275 | ochoa | Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) (KDAO) | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses (PubMed:12072962). Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism (PubMed:12072962). It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes (PubMed:12072962, PubMed:239684). {ECO:0000269|PubMed:12072962, ECO:0000269|PubMed:19764817, ECO:0000269|PubMed:239684, ECO:0000269|PubMed:8144586}. |
| P25054 | APC | Y1031 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27348 | YWHAQ | S37 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P28066 | PSMA5 | S62 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P28715 | ERCC5 | S724 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P28715 | ERCC5 | S1132 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29374 | ARID4A | S863 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P31946 | YWHAB | S39 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S37 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P38398 | BRCA1 | S1164 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42684 | ABL2 | S96 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46013 | MKI67 | S1118 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1970 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2575 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S3082 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | Y1904 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S2086 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47710 | CSN1S1 | S90 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P48163 | ME1 | S336 | psp | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| P48651 | PTDSS1 | Y424 | ochoa | Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}. |
| P49792 | RANBP2 | S2008 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50747 | HLCS | S124 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P51532 | SMARCA4 | S1382 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P57053 | H2BC12L | S56 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | S56 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P59998 | ARPC4 | S42 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| P61981 | YWHAG | S38 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62333 | PSMC6 | S131 | ochoa | 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P62807 | H2BC4 | S56 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P63104 | YWHAZ | S28 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63104 | YWHAZ | S37 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78362 | SRPK2 | S380 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| Q01082 | SPTBN1 | S1057 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01804 | OTUD4 | S922 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q02952 | AKAP12 | S612 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03135 | CAV1 | S80 | psp | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q03701 | CEBPZ | S41 | ochoa | CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) | Stimulates transcription from the HSP70 promoter. |
| Q06413 | MEF2C | S453 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q0ZGT2 | NEXN | S218 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12830 | BPTF | S742 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12986 | NFX1 | S123 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13129 | RLF | S1022 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13765 | NACA | S166 | psp | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| Q13772 | NCOA4 | S186 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q14126 | DSG2 | S911 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14134 | TRIM29 | S272 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14151 | SAFB2 | S320 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14568 | HSP90AA2P | S169 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q14789 | GOLGB1 | S671 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S3037 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14966 | ZNF638 | S1243 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14980 | NUMA1 | S820 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15061 | WDR43 | S437 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15149 | PLEC | S1732 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15424 | SAFB | S321 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16778 | H2BC21 | S56 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q1KMD3 | HNRNPUL2 | S597 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2KHR3 | QSER1 | S1230 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q3KR37 | GRAMD1B | S550 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q5BKX6 | SLC45A4 | S43 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5QNW6 | H2BC18 | S56 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5SW79 | CEP170 | S239 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S739 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SXM2 | SNAPC4 | S68 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5VT06 | CEP350 | S2174 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VVJ2 | MYSM1 | S267 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q6BDS2 | BLTP3A | S936 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6JBY9 | RCSD1 | S267 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6ZUM4 | ARHGAP27 | S481 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q6ZWJ1 | STXBP4 | S82 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q70CQ2 | USP34 | S3358 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70EL1 | USP54 | S1188 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7Z3J3 | RGPD4 | S1033 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z406 | MYH14 | S1328 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z434 | MAVS | S285 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z6Z7 | HUWE1 | S1736 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U86 | PBRM1 | S987 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VP1 | TAX1BP1 | S344 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86XJ1 | GAS2L3 | S195 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IW35 | CEP97 | S763 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWA0 | WDR75 | S796 | ochoa | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8IX90 | SKA3 | S124 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8N257 | H2BC26 | S56 | ochoa | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8N573 | OXR1 | S526 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5C8 | TAB3 | S492 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N8S7 | ENAH | S477 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8N960 | CEP120 | S347 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
| Q8N9T8 | KRI1 | S136 | ochoa | Protein KRI1 homolog | None |
| Q8N9T8 | KRI1 | S217 | ochoa | Protein KRI1 homolog | None |
| Q8NF99 | ZNF397 | S31 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8NHP6 | MOSPD2 | S266 | ochoa | Motile sperm domain-containing protein 2 | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}. |
| Q8NHP6 | MOSPD2 | S283 | ochoa | Motile sperm domain-containing protein 2 | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}. |
| Q8NHV4 | NEDD1 | S493 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI08 | NCOA7 | S595 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TDY2 | RB1CC1 | S274 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEA7 | TBCK | S416 | ochoa | TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). Also involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:23977024, PubMed:27040691). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). {ECO:0000269|PubMed:23977024, ECO:0000269|PubMed:24576458, ECO:0000269|PubMed:27040691, ECO:0000269|PubMed:37267905}. |
| Q8WUY3 | PRUNE2 | S1719 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVC0 | LEO1 | S154 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q92547 | TOPBP1 | S492 | ochoa|psp | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92551 | IP6K1 | S145 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q93079 | H2BC9 | S56 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q969K3 | RNF34 | S323 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96A08 | H2BC1 | S57 | ochoa | Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B) | Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). {ECO:0000250|UniProtKB:P70696, ECO:0000269|PubMed:21249133}. |
| Q96BT3 | CENPT | S343 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96CV9 | OPTN | S191 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96CV9 | OPTN | S513 | ochoa|psp | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96GX5 | MASTL | S602 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96RF0 | SNX18 | S20 | ochoa | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}. |
| Q96T58 | SPEN | S1622 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99666 | RGPD5 | S1032 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99733 | NAP1L4 | S22 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q99877 | H2BC15 | S56 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S56 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | S56 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BUF7 | CRB3 | S96 | ochoa | Protein crumbs homolog 3 | Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572, PubMed:23439680). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:Q8QZT4, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572, ECO:0000269|PubMed:23439680}. |
| Q9BVS4 | RIOK2 | S385 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BX66 | SORBS1 | S684 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BYW2 | SETD2 | S262 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0C2 | TNKS1BP1 | S1008 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D0 | PHACTR1 | S172 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9H009 | NACA2 | S166 | ochoa | Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| Q9H425 | C1orf198 | S129 | ochoa | Uncharacterized protein C1orf198 | None |
| Q9H6R4 | NOL6 | T27 | ochoa | Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}. |
| Q9H6Z4 | RANBP3 | S358 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H8G2 | CAAP1 | S301 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9HAW7 | UGT1A7 | S432 | psp | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP) (PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:21422672, ECO:0000269|PubMed:23360619, ECO:0000269|PubMed:38211441}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23360619}. |
| Q9HAW8 | UGT1A10 | S432 | psp | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143, PubMed:15231852, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and PGB1 (PubMed:15231852). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15231852, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:21422672, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:26220143}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}. |
| Q9HBM0 | VEZT | S668 | ochoa | Vezatin | Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}. |
| Q9HCY8 | S100A14 | S77 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9NQ86 | TRIM36 | S462 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NQB0 | TCF7L2 | S35 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NR09 | BIRC6 | S547 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NSI6 | BRWD1 | S2131 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NTJ3 | SMC4 | S982 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NU22 | MDN1 | S4752 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NYF8 | BCLAF1 | S198 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S385 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9UHB6 | LIMA1 | S168 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB6 | LIMA1 | S741 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UK61 | TASOR | S818 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKK3 | PARP4 | S1288 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKL3 | CASP8AP2 | S1270 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKS7 | IKZF2 | S79 | ochoa | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}. |
| Q9ULV4 | CORO1C | S309 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9UPM8 | AP4E1 | S871 | psp | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UQ80 | PA2G4 | S34 | psp | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y2D8 | SSX2IP | S452 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2J2 | EPB41L3 | S833 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2K5 | R3HDM2 | S142 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y6Y8 | SEC23IP | S930 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| R4GMW8 | BIVM-ERCC5 | S1178 | ochoa | DNA excision repair protein ERCC-5 | None |
| R4GMW8 | BIVM-ERCC5 | S1586 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q6UXH1 | CRELD2 | S295 | Sugiyama | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q14257 | RCN2 | S207 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| P13667 | PDIA4 | Y458 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P31153 | MAT2A | Y235 | Sugiyama | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
| Q99426 | TBCB | S163 | Sugiyama | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| P22033 | MMUT | S481 | Sugiyama | Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase) | Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. {ECO:0000269|PubMed:1346616, ECO:0000269|PubMed:1978672, ECO:0000269|PubMed:21138732, ECO:0000269|PubMed:24458, ECO:0000269|PubMed:2453061, ECO:0000269|PubMed:25125334, ECO:0000269|PubMed:27167370, ECO:0000269|PubMed:28101778, ECO:0000269|PubMed:28943303, ECO:0000269|PubMed:29056341}. |
| P05787 | KRT8 | S274 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P10721 | KIT | S717 | Sugiyama | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| Q86V48 | LUZP1 | S703 | Sugiyama | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q9BWD1 | ACAT2 | S226 | Sugiyama | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase) | Involved in the biosynthetic pathway of cholesterol. {ECO:0000303|PubMed:15733928}. |
| Q99250 | SCN2A | S1126 | SIGNOR | Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}. |
| O75496 | GMNN | S184 | PSP | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| Q13043 | STK4 | S75 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P54136 | RARS1 | S329 | Sugiyama | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}. |
| Q92878 | RAD50 | S623 | Sugiyama | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q96K76 | USP47 | S920 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q8WUA2 | PPIL4 | S425 | Sugiyama | Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.110223e-16 | 15.955 |
| R-HSA-69481 | G2/M Checkpoints | 1.110223e-16 | 15.955 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.043610e-14 | 13.981 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.598721e-14 | 13.796 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.476597e-14 | 13.831 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.153033e-14 | 13.501 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.153033e-14 | 13.501 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.430589e-14 | 13.465 |
| R-HSA-5334118 | DNA methylation | 6.250556e-14 | 13.204 |
| R-HSA-912446 | Meiotic recombination | 6.894485e-14 | 13.161 |
| R-HSA-1221632 | Meiotic synapsis | 1.075806e-13 | 12.968 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.622036e-13 | 12.790 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.191580e-13 | 12.659 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.455813e-13 | 12.610 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.055334e-13 | 12.515 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.897682e-13 | 12.538 |
| R-HSA-774815 | Nucleosome assembly | 3.637091e-13 | 12.439 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.637091e-13 | 12.439 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.742562e-13 | 12.427 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.905765e-13 | 12.408 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.586331e-13 | 12.339 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 6.766809e-13 | 12.170 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 8.818501e-13 | 12.055 |
| R-HSA-110331 | Cleavage of the damaged purine | 8.818501e-13 | 12.055 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.099898e-12 | 11.959 |
| R-HSA-73927 | Depurination | 1.142086e-12 | 11.942 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.661338e-12 | 11.780 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.882383e-12 | 11.725 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.882383e-12 | 11.725 |
| R-HSA-1500620 | Meiosis | 2.034817e-12 | 11.691 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.396860e-12 | 11.620 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.396860e-12 | 11.620 |
| R-HSA-68875 | Mitotic Prophase | 2.839728e-12 | 11.547 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.079870e-12 | 11.511 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.826273e-12 | 11.417 |
| R-HSA-73928 | Depyrimidination | 3.826273e-12 | 11.417 |
| R-HSA-9710421 | Defective pyroptosis | 4.799272e-12 | 11.319 |
| R-HSA-211000 | Gene Silencing by RNA | 5.411116e-12 | 11.267 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.864709e-12 | 11.104 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.864709e-12 | 11.104 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.428258e-12 | 11.074 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.121303e-11 | 10.950 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.209188e-11 | 10.656 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.403622e-11 | 10.619 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.054457e-11 | 10.515 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.683631e-11 | 10.434 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.190048e-11 | 10.378 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.428091e-11 | 10.354 |
| R-HSA-1640170 | Cell Cycle | 6.933565e-11 | 10.159 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.733536e-11 | 10.112 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.343082e-10 | 9.872 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.738939e-10 | 9.760 |
| R-HSA-5693538 | Homology Directed Repair | 2.525158e-10 | 9.598 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.387812e-10 | 9.470 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.365841e-10 | 9.360 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.832298e-10 | 9.234 |
| R-HSA-68886 | M Phase | 5.477288e-10 | 9.261 |
| R-HSA-5688426 | Deubiquitination | 5.875741e-10 | 9.231 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.720932e-10 | 9.173 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.720932e-10 | 9.173 |
| R-HSA-1474165 | Reproduction | 9.808810e-10 | 9.008 |
| R-HSA-195721 | Signaling by WNT | 1.173170e-09 | 8.931 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.328179e-09 | 8.877 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.723010e-09 | 8.764 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.832378e-09 | 8.737 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.220750e-09 | 8.654 |
| R-HSA-977225 | Amyloid fiber formation | 2.515292e-09 | 8.599 |
| R-HSA-3214847 | HATs acetylate histones | 2.566094e-09 | 8.591 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.844588e-09 | 8.546 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.729206e-09 | 8.325 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.084669e-09 | 8.294 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.084669e-09 | 8.294 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.084669e-09 | 8.294 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 7.065279e-09 | 8.151 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.556402e-09 | 8.183 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.468129e-09 | 8.189 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 7.706329e-09 | 8.113 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.961127e-09 | 8.099 |
| R-HSA-69306 | DNA Replication | 7.961127e-09 | 8.099 |
| R-HSA-73884 | Base Excision Repair | 8.082458e-09 | 8.092 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 9.018263e-09 | 8.045 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.038596e-08 | 7.984 |
| R-HSA-4839726 | Chromatin organization | 1.559895e-08 | 7.807 |
| R-HSA-157579 | Telomere Maintenance | 2.078862e-08 | 7.682 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.408717e-08 | 7.618 |
| R-HSA-73886 | Chromosome Maintenance | 2.788457e-08 | 7.555 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.094759e-08 | 7.509 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.302040e-08 | 7.481 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.386072e-08 | 7.470 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.233162e-08 | 7.373 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.233162e-08 | 7.373 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.233162e-08 | 7.373 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.486014e-08 | 7.348 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.486014e-08 | 7.348 |
| R-HSA-446728 | Cell junction organization | 7.144882e-08 | 7.146 |
| R-HSA-1500931 | Cell-Cell communication | 8.414429e-08 | 7.075 |
| R-HSA-418990 | Adherens junctions interactions | 9.490954e-08 | 7.023 |
| R-HSA-421270 | Cell-cell junction organization | 9.869518e-08 | 7.006 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.956805e-08 | 7.002 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.474127e-07 | 6.831 |
| R-HSA-8852135 | Protein ubiquitination | 1.536296e-07 | 6.814 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.113204e-07 | 6.675 |
| R-HSA-8939211 | ESR-mediated signaling | 2.627579e-07 | 6.580 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.316698e-07 | 6.365 |
| R-HSA-9610379 | HCMV Late Events | 5.228404e-07 | 6.282 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.663625e-07 | 6.176 |
| R-HSA-9609690 | HCMV Early Events | 8.920402e-07 | 6.050 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.234614e-06 | 5.908 |
| R-HSA-157118 | Signaling by NOTCH | 1.593518e-06 | 5.798 |
| R-HSA-2559583 | Cellular Senescence | 2.131733e-06 | 5.671 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.160113e-06 | 5.500 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 5.398539e-06 | 5.268 |
| R-HSA-73894 | DNA Repair | 9.233501e-06 | 5.035 |
| R-HSA-9609646 | HCMV Infection | 1.177559e-05 | 4.929 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.169831e-05 | 4.664 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.848228e-05 | 4.415 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.054224e-05 | 4.392 |
| R-HSA-9824446 | Viral Infection Pathways | 6.223923e-05 | 4.206 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.096926e-05 | 4.041 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.106973e-04 | 3.956 |
| R-HSA-109581 | Apoptosis | 1.223317e-04 | 3.912 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.563084e-04 | 3.806 |
| R-HSA-5357801 | Programmed Cell Death | 1.706954e-04 | 3.768 |
| R-HSA-74160 | Gene expression (Transcription) | 1.761472e-04 | 3.754 |
| R-HSA-212436 | Generic Transcription Pathway | 4.050609e-04 | 3.392 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.112670e-04 | 3.291 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.834024e-04 | 3.234 |
| R-HSA-2262752 | Cellular responses to stress | 7.999352e-04 | 3.097 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.549372e-04 | 3.020 |
| R-HSA-9679506 | SARS-CoV Infections | 1.237703e-03 | 2.907 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.476748e-03 | 2.831 |
| R-HSA-1266738 | Developmental Biology | 1.870406e-03 | 2.728 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.945671e-03 | 2.711 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.950699e-03 | 2.710 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 2.000324e-03 | 2.699 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.262877e-03 | 2.486 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.634222e-03 | 2.440 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 3.726296e-03 | 2.429 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.035584e-03 | 2.394 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.050444e-03 | 2.392 |
| R-HSA-68877 | Mitotic Prometaphase | 6.215159e-03 | 2.207 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 7.416957e-03 | 2.130 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 7.416957e-03 | 2.130 |
| R-HSA-1266695 | Interleukin-7 signaling | 7.561249e-03 | 2.121 |
| R-HSA-156588 | Glucuronidation | 8.517146e-03 | 2.070 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.900207e-03 | 2.051 |
| R-HSA-1280218 | Adaptive Immune System | 9.678861e-03 | 2.014 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.973185e-03 | 2.001 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.048802e-02 | 1.979 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.050437e-02 | 1.979 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.123069e-02 | 1.950 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.222617e-02 | 1.913 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669921 | KIT mutants bind TKIs | 1.265025e-02 | 1.898 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.265025e-02 | 1.898 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 1.265025e-02 | 1.898 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.595473e-02 | 1.797 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.398638e-02 | 1.854 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.595473e-02 | 1.797 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.280376e-02 | 1.893 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.342038e-02 | 1.872 |
| R-HSA-373755 | Semaphorin interactions | 1.342038e-02 | 1.872 |
| R-HSA-162582 | Signal Transduction | 1.403565e-02 | 1.853 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.305728e-02 | 1.884 |
| R-HSA-69275 | G2/M Transition | 1.678791e-02 | 1.775 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.699429e-02 | 1.770 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.737139e-02 | 1.760 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.759838e-02 | 1.755 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.759838e-02 | 1.755 |
| R-HSA-5663205 | Infectious disease | 1.763797e-02 | 1.754 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.826684e-02 | 1.738 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.918471e-02 | 1.717 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.982664e-02 | 1.703 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.982664e-02 | 1.703 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.033574e-02 | 1.692 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.065242e-02 | 1.685 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.152403e-02 | 1.667 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.248991e-02 | 1.648 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.274961e-02 | 1.643 |
| R-HSA-597592 | Post-translational protein modification | 2.280463e-02 | 1.642 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.401248e-02 | 1.620 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.401248e-02 | 1.620 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.480205e-02 | 1.606 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.514124e-02 | 1.600 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.514124e-02 | 1.600 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.986414e-02 | 1.525 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.986414e-02 | 1.525 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 3.747496e-02 | 1.426 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 3.747496e-02 | 1.426 |
| R-HSA-3359475 | Defective MMAA causes MMA, cblA type | 3.747496e-02 | 1.426 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 3.747496e-02 | 1.426 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 3.747496e-02 | 1.426 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.805721e-02 | 1.420 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.095778e-02 | 1.388 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.095778e-02 | 1.388 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.095778e-02 | 1.388 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.095778e-02 | 1.388 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.638561e-02 | 1.439 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.873139e-02 | 1.412 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.523968e-02 | 1.453 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.089088e-02 | 1.510 |
| R-HSA-392517 | Rap1 signalling | 3.805721e-02 | 1.420 |
| R-HSA-2028269 | Signaling by Hippo | 3.250778e-02 | 1.488 |
| R-HSA-9675135 | Diseases of DNA repair | 3.237040e-02 | 1.490 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.805721e-02 | 1.420 |
| R-HSA-75153 | Apoptotic execution phase | 3.237040e-02 | 1.490 |
| R-HSA-9909396 | Circadian clock | 4.202426e-02 | 1.376 |
| R-HSA-72312 | rRNA processing | 4.376892e-02 | 1.359 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.627724e-02 | 1.335 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 4.699801e-02 | 1.328 |
| R-HSA-9753281 | Paracetamol ADME | 4.737513e-02 | 1.324 |
| R-HSA-8953854 | Metabolism of RNA | 4.744362e-02 | 1.324 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.831096e-02 | 1.316 |
| R-HSA-199991 | Membrane Trafficking | 4.832414e-02 | 1.316 |
| R-HSA-75893 | TNF signaling | 4.922035e-02 | 1.308 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.922035e-02 | 1.308 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.965340e-02 | 1.304 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.965340e-02 | 1.304 |
| R-HSA-3359478 | Defective MUT causes MMAM | 4.965340e-02 | 1.304 |
| R-HSA-9759785 | Diseases of propionyl-CoA catabolism | 4.965340e-02 | 1.304 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.965340e-02 | 1.304 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.965340e-02 | 1.304 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.965340e-02 | 1.304 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.965340e-02 | 1.304 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.965340e-02 | 1.304 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.965340e-02 | 1.304 |
| R-HSA-9759774 | Diseases of mitochondrial beta oxidation | 4.965340e-02 | 1.304 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.965340e-02 | 1.304 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.965340e-02 | 1.304 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.965340e-02 | 1.304 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.110033e-02 | 1.292 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.110033e-02 | 1.292 |
| R-HSA-168256 | Immune System | 5.265832e-02 | 1.279 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 5.334072e-02 | 1.273 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.195701e-01 | 0.922 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.195701e-01 | 0.922 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.195701e-01 | 0.922 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.195701e-01 | 0.922 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.195701e-01 | 0.922 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.195701e-01 | 0.922 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.195701e-01 | 0.922 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.307147e-01 | 0.884 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.307147e-01 | 0.884 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.307147e-01 | 0.884 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.417188e-01 | 0.849 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.525843e-01 | 0.816 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.633130e-01 | 0.787 |
| R-HSA-4839744 | Signaling by APC mutants | 1.633130e-01 | 0.787 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.633130e-01 | 0.787 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.633130e-01 | 0.787 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.633130e-01 | 0.787 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.739064e-01 | 0.760 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.739064e-01 | 0.760 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.739064e-01 | 0.760 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 5.996705e-02 | 1.222 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 7.765660e-02 | 1.110 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 8.137019e-02 | 1.090 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 8.137019e-02 | 1.090 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 8.895696e-02 | 1.051 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 8.895696e-02 | 1.051 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 9.282629e-02 | 1.032 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.007075e-01 | 0.997 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.169907e-01 | 0.932 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.211600e-01 | 0.917 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.309419e-02 | 1.200 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.309419e-02 | 1.200 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.953644e-02 | 1.158 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.565991e-02 | 1.067 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.512722e-01 | 0.820 |
| R-HSA-380287 | Centrosome maturation | 9.053415e-02 | 1.043 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.296056e-01 | 0.887 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.512722e-01 | 0.820 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.512722e-01 | 0.820 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.512722e-01 | 0.820 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 8.527628e-02 | 1.069 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.417188e-01 | 0.849 |
| R-HSA-9907900 | Proteasome assembly | 1.425182e-01 | 0.846 |
| R-HSA-8849473 | PTK6 Expression | 1.195701e-01 | 0.922 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.417188e-01 | 0.849 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.739064e-01 | 0.760 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.087670e-01 | 0.964 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.296056e-01 | 0.887 |
| R-HSA-4791275 | Signaling by WNT in cancer | 8.513762e-02 | 1.070 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 9.282629e-02 | 1.032 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 6.338089e-02 | 1.198 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 9.685276e-02 | 1.014 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 8.895696e-02 | 1.051 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.128591e-01 | 0.947 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.174764e-02 | 1.144 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 8.137019e-02 | 1.090 |
| R-HSA-203615 | eNOS activation | 9.674376e-02 | 1.014 |
| R-HSA-1483101 | Synthesis of PS | 9.685276e-02 | 1.014 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.525843e-01 | 0.816 |
| R-HSA-192905 | vRNP Assembly | 1.633130e-01 | 0.787 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.739064e-01 | 0.760 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.739064e-01 | 0.760 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.739064e-01 | 0.760 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.685889e-02 | 1.175 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 8.137019e-02 | 1.090 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.087670e-01 | 0.964 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.468816e-01 | 0.833 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.512722e-01 | 0.820 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.461132e-02 | 1.073 |
| R-HSA-6798695 | Neutrophil degranulation | 1.585996e-01 | 0.800 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.417188e-01 | 0.849 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.685889e-02 | 1.175 |
| R-HSA-3371511 | HSF1 activation | 1.047159e-01 | 0.980 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 8.527628e-02 | 1.069 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.417188e-01 | 0.849 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 6.685889e-02 | 1.175 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 9.282629e-02 | 1.032 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.307147e-01 | 0.884 |
| R-HSA-170984 | ARMS-mediated activation | 1.417188e-01 | 0.849 |
| R-HSA-1483226 | Synthesis of PI | 1.633130e-01 | 0.787 |
| R-HSA-71032 | Propionyl-CoA catabolism | 1.633130e-01 | 0.787 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.739064e-01 | 0.760 |
| R-HSA-5689901 | Metalloprotease DUBs | 6.338089e-02 | 1.198 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 8.513762e-02 | 1.070 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.007075e-01 | 0.997 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.007075e-01 | 0.997 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.296056e-01 | 0.887 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.296056e-01 | 0.887 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.556886e-01 | 0.808 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.845147e-02 | 1.165 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.781126e-01 | 0.749 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.605795e-01 | 0.794 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 5.996705e-02 | 1.222 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 5.996705e-02 | 1.222 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 8.565991e-02 | 1.067 |
| R-HSA-9733709 | Cardiogenesis | 8.895696e-02 | 1.051 |
| R-HSA-180746 | Nuclear import of Rev protein | 9.674376e-02 | 1.014 |
| R-HSA-4641258 | Degradation of DVL | 1.087670e-01 | 0.964 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.169907e-01 | 0.932 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.514577e-02 | 1.124 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 7.355214e-02 | 1.133 |
| R-HSA-444821 | Relaxin receptors | 9.685276e-02 | 1.014 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 1.007075e-01 | 0.997 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.047159e-01 | 0.980 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.047159e-01 | 0.980 |
| R-HSA-4641257 | Degradation of AXIN | 1.087670e-01 | 0.964 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.087670e-01 | 0.964 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.211600e-01 | 0.917 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.211600e-01 | 0.917 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.253655e-01 | 0.902 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.735865e-01 | 0.760 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.781126e-01 | 0.749 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.047159e-01 | 0.980 |
| R-HSA-3371556 | Cellular response to heat stress | 9.517475e-02 | 1.021 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.417188e-01 | 0.849 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.633130e-01 | 0.787 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 8.895696e-02 | 1.051 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 9.282629e-02 | 1.032 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 9.674376e-02 | 1.014 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 9.674376e-02 | 1.014 |
| R-HSA-169911 | Regulation of Apoptosis | 1.007075e-01 | 0.997 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.128591e-01 | 0.947 |
| R-HSA-3371568 | Attenuation phase | 1.211600e-01 | 0.917 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.296056e-01 | 0.887 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.296056e-01 | 0.887 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.512722e-01 | 0.820 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.690798e-01 | 0.772 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.781126e-01 | 0.749 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.192815e-01 | 0.923 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.805694e-02 | 1.009 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.169907e-01 | 0.932 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.253655e-01 | 0.902 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.096817e-01 | 0.960 |
| R-HSA-69242 | S Phase | 1.629952e-01 | 0.788 |
| R-HSA-9707616 | Heme signaling | 6.101169e-02 | 1.215 |
| R-HSA-9659379 | Sensory processing of sound | 1.006193e-01 | 0.997 |
| R-HSA-9013694 | Signaling by NOTCH4 | 8.808267e-02 | 1.055 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.087670e-01 | 0.964 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.169907e-01 | 0.932 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.399017e-02 | 1.131 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.381834e-01 | 0.860 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.425182e-01 | 0.846 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.468816e-01 | 0.833 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.425182e-01 | 0.846 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.739064e-01 | 0.760 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.569285e-01 | 0.804 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.010341e-01 | 0.996 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.599647e-01 | 0.796 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.468816e-01 | 0.833 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.512722e-01 | 0.820 |
| R-HSA-1643685 | Disease | 7.043474e-02 | 1.152 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.211600e-01 | 0.917 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.253655e-01 | 0.902 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.468816e-01 | 0.833 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.722847e-01 | 0.764 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.307147e-01 | 0.884 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.417188e-01 | 0.849 |
| R-HSA-9766229 | Degradation of CDH1 | 1.645938e-01 | 0.784 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.735865e-01 | 0.760 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.468816e-01 | 0.833 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.468816e-01 | 0.833 |
| R-HSA-9675108 | Nervous system development | 8.598089e-02 | 1.066 |
| R-HSA-422475 | Axon guidance | 1.098750e-01 | 0.959 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.735865e-01 | 0.760 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.678660e-01 | 0.775 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.165406e-01 | 0.934 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.420312e-01 | 0.848 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 1.151239e-01 | 0.939 |
| R-HSA-69541 | Stabilization of p53 | 1.169907e-01 | 0.932 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.735865e-01 | 0.760 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.169907e-01 | 0.932 |
| R-HSA-9824272 | Somitogenesis | 1.468816e-01 | 0.833 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.633792e-02 | 1.178 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.425182e-01 | 0.846 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.645938e-01 | 0.784 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.645938e-01 | 0.784 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.682840e-02 | 1.175 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.634307e-01 | 0.787 |
| R-HSA-9749641 | Aspirin ADME | 8.565991e-02 | 1.067 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.220462e-01 | 0.913 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 9.517475e-02 | 1.021 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.682840e-02 | 1.175 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.169907e-01 | 0.932 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.781126e-01 | 0.749 |
| R-HSA-1989781 | PPARA activates gene expression | 1.802644e-01 | 0.744 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.826570e-01 | 0.738 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.826570e-01 | 0.738 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.826570e-01 | 0.738 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.826570e-01 | 0.738 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.826570e-01 | 0.738 |
| R-HSA-9612973 | Autophagy | 1.827804e-01 | 0.738 |
| R-HSA-68882 | Mitotic Anaphase | 1.842338e-01 | 0.735 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.843664e-01 | 0.734 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.843664e-01 | 0.734 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-4641265 | Repression of WNT target genes | 1.843664e-01 | 0.734 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.843664e-01 | 0.734 |
| R-HSA-9833110 | RSV-host interactions | 1.848650e-01 | 0.733 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.853081e-01 | 0.732 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.863859e-01 | 0.730 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.872183e-01 | 0.728 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.880477e-01 | 0.726 |
| R-HSA-9748784 | Drug ADME | 1.885473e-01 | 0.725 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.894318e-01 | 0.723 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.895278e-01 | 0.722 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.917955e-01 | 0.717 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.929591e-01 | 0.715 |
| R-HSA-69239 | Synthesis of DNA | 1.944553e-01 | 0.711 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.946945e-01 | 0.711 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.946945e-01 | 0.711 |
| R-HSA-170968 | Frs2-mediated activation | 1.946945e-01 | 0.711 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.946945e-01 | 0.711 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.963875e-01 | 0.707 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.009931e-01 | 0.697 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.030020e-01 | 0.692 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.041663e-01 | 0.690 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.041663e-01 | 0.690 |
| R-HSA-202403 | TCR signaling | 2.041663e-01 | 0.690 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.048925e-01 | 0.688 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 2.048925e-01 | 0.688 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.048925e-01 | 0.688 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.048925e-01 | 0.688 |
| R-HSA-191859 | snRNP Assembly | 2.102410e-01 | 0.677 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.102410e-01 | 0.677 |
| R-HSA-351202 | Metabolism of polyamines | 2.148812e-01 | 0.668 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.149620e-01 | 0.668 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.149620e-01 | 0.668 |
| R-HSA-196780 | Biotin transport and metabolism | 2.149620e-01 | 0.668 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.149620e-01 | 0.668 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.149620e-01 | 0.668 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.149620e-01 | 0.668 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.169168e-01 | 0.664 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.195310e-01 | 0.659 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.195310e-01 | 0.659 |
| R-HSA-450294 | MAP kinase activation | 2.195310e-01 | 0.659 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.195310e-01 | 0.659 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.241893e-01 | 0.649 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.241893e-01 | 0.649 |
| R-HSA-169893 | Prolonged ERK activation events | 2.249046e-01 | 0.648 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.249046e-01 | 0.648 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.249046e-01 | 0.648 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.272350e-01 | 0.644 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.288551e-01 | 0.640 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.335276e-01 | 0.632 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.347219e-01 | 0.629 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.347219e-01 | 0.629 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.347219e-01 | 0.629 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.347219e-01 | 0.629 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.382058e-01 | 0.623 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.382058e-01 | 0.623 |
| R-HSA-392499 | Metabolism of proteins | 2.396977e-01 | 0.620 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.444154e-01 | 0.612 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.444154e-01 | 0.612 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.473848e-01 | 0.607 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.522661e-01 | 0.598 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.539867e-01 | 0.595 |
| R-HSA-3928664 | Ephrin signaling | 2.539867e-01 | 0.595 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.616526e-01 | 0.582 |
| R-HSA-448424 | Interleukin-17 signaling | 2.616526e-01 | 0.582 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.616526e-01 | 0.582 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.616526e-01 | 0.582 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.634374e-01 | 0.579 |
| R-HSA-194138 | Signaling by VEGF | 2.643812e-01 | 0.578 |
| R-HSA-69206 | G1/S Transition | 2.643812e-01 | 0.578 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.663473e-01 | 0.575 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.663473e-01 | 0.575 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.663473e-01 | 0.575 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.710420e-01 | 0.567 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.710420e-01 | 0.567 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.727689e-01 | 0.564 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.727689e-01 | 0.564 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.727689e-01 | 0.564 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.727689e-01 | 0.564 |
| R-HSA-373753 | Nephrin family interactions | 2.727689e-01 | 0.564 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.757359e-01 | 0.560 |
| R-HSA-5617833 | Cilium Assembly | 2.767684e-01 | 0.558 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.819828e-01 | 0.550 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.819828e-01 | 0.550 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.819828e-01 | 0.550 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.819828e-01 | 0.550 |
| R-HSA-198753 | ERK/MAPK targets | 2.819828e-01 | 0.550 |
| R-HSA-210991 | Basigin interactions | 2.819828e-01 | 0.550 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.851183e-01 | 0.545 |
| R-HSA-5689603 | UCH proteinases | 2.898055e-01 | 0.538 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.910805e-01 | 0.536 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.910805e-01 | 0.536 |
| R-HSA-977347 | Serine metabolism | 2.910805e-01 | 0.536 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.944891e-01 | 0.531 |
| R-HSA-5619084 | ABC transporter disorders | 2.991685e-01 | 0.524 |
| R-HSA-4086400 | PCP/CE pathway | 2.991685e-01 | 0.524 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.000634e-01 | 0.523 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.000634e-01 | 0.523 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.000634e-01 | 0.523 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.000634e-01 | 0.523 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.000634e-01 | 0.523 |
| R-HSA-8964038 | LDL clearance | 3.000634e-01 | 0.523 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.091210e-01 | 0.510 |
| R-HSA-449147 | Signaling by Interleukins | 3.094608e-01 | 0.509 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.107648e-01 | 0.508 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.136191e-01 | 0.504 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.176910e-01 | 0.498 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.176910e-01 | 0.498 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.176910e-01 | 0.498 |
| R-HSA-429947 | Deadenylation of mRNA | 3.176910e-01 | 0.498 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.176910e-01 | 0.498 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.178309e-01 | 0.498 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.209310e-01 | 0.494 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.224797e-01 | 0.491 |
| R-HSA-420029 | Tight junction interactions | 3.263384e-01 | 0.486 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.263384e-01 | 0.486 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 3.263384e-01 | 0.486 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.263384e-01 | 0.486 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.264295e-01 | 0.486 |
| R-HSA-1632852 | Macroautophagy | 3.264295e-01 | 0.486 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.317533e-01 | 0.479 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.348767e-01 | 0.475 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.348767e-01 | 0.475 |
| R-HSA-525793 | Myogenesis | 3.348767e-01 | 0.475 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.363770e-01 | 0.473 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.363770e-01 | 0.473 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.368164e-01 | 0.473 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.402774e-01 | 0.468 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.433073e-01 | 0.464 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 3.433073e-01 | 0.464 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.471956e-01 | 0.459 |
| R-HSA-9663891 | Selective autophagy | 3.501894e-01 | 0.456 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.516316e-01 | 0.454 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.516316e-01 | 0.454 |
| R-HSA-622312 | Inflammasomes | 3.516316e-01 | 0.454 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.541073e-01 | 0.451 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.547724e-01 | 0.450 |
| R-HSA-9758941 | Gastrulation | 3.575600e-01 | 0.447 |
| R-HSA-202424 | Downstream TCR signaling | 3.593441e-01 | 0.444 |
| R-HSA-209968 | Thyroxine biosynthesis | 3.598508e-01 | 0.444 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.598508e-01 | 0.444 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.598508e-01 | 0.444 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.610103e-01 | 0.442 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.639040e-01 | 0.439 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.679026e-01 | 0.434 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.679664e-01 | 0.434 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.679664e-01 | 0.434 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.679664e-01 | 0.434 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.679664e-01 | 0.434 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.679664e-01 | 0.434 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.729866e-01 | 0.428 |
| R-HSA-73887 | Death Receptor Signaling | 3.747824e-01 | 0.426 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.747824e-01 | 0.426 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.759796e-01 | 0.425 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.782170e-01 | 0.422 |
| R-HSA-162906 | HIV Infection | 3.853392e-01 | 0.414 |
| R-HSA-211859 | Biological oxidations | 3.899673e-01 | 0.409 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.909922e-01 | 0.408 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.917039e-01 | 0.407 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.954581e-01 | 0.403 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.994176e-01 | 0.399 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.994176e-01 | 0.399 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.043448e-01 | 0.393 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.043448e-01 | 0.393 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.043448e-01 | 0.393 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.070339e-01 | 0.390 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.070339e-01 | 0.390 |
| R-HSA-5673000 | RAF activation | 4.070339e-01 | 0.390 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.070339e-01 | 0.390 |
| R-HSA-5205647 | Mitophagy | 4.070339e-01 | 0.390 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.094503e-01 | 0.388 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.131692e-01 | 0.384 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.131692e-01 | 0.384 |
| R-HSA-70171 | Glycolysis | 4.131692e-01 | 0.384 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.131692e-01 | 0.384 |
| R-HSA-187687 | Signalling to ERKs | 4.145541e-01 | 0.382 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.145541e-01 | 0.382 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.175573e-01 | 0.379 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.219289e-01 | 0.375 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.219794e-01 | 0.375 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.219794e-01 | 0.375 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.219794e-01 | 0.375 |
| R-HSA-163560 | Triglyceride catabolism | 4.219794e-01 | 0.375 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.219794e-01 | 0.375 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.293109e-01 | 0.367 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.357154e-01 | 0.361 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.358428e-01 | 0.361 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.365499e-01 | 0.360 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.421643e-01 | 0.354 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.436976e-01 | 0.353 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.436976e-01 | 0.353 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.436976e-01 | 0.353 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.458210e-01 | 0.351 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.507550e-01 | 0.346 |
| R-HSA-9646399 | Aggrephagy | 4.507550e-01 | 0.346 |
| R-HSA-202433 | Generation of second messenger molecules | 4.507550e-01 | 0.346 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.520453e-01 | 0.345 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.520453e-01 | 0.345 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.562754e-01 | 0.341 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.562754e-01 | 0.341 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.577233e-01 | 0.339 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.577233e-01 | 0.339 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.577233e-01 | 0.339 |
| R-HSA-9607240 | FLT3 Signaling | 4.577233e-01 | 0.339 |
| R-HSA-168255 | Influenza Infection | 4.622947e-01 | 0.335 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.646036e-01 | 0.333 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.646036e-01 | 0.333 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.713970e-01 | 0.327 |
| R-HSA-165159 | MTOR signalling | 4.713970e-01 | 0.327 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.713970e-01 | 0.327 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.713970e-01 | 0.327 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.730067e-01 | 0.325 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.781047e-01 | 0.320 |
| R-HSA-8854214 | TBC/RABGAPs | 4.781047e-01 | 0.320 |
| R-HSA-156581 | Methylation | 4.847276e-01 | 0.315 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.847276e-01 | 0.315 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.847276e-01 | 0.315 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.847276e-01 | 0.315 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.853511e-01 | 0.314 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.865014e-01 | 0.313 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.912669e-01 | 0.309 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.912669e-01 | 0.309 |
| R-HSA-373760 | L1CAM interactions | 4.934810e-01 | 0.307 |
| R-HSA-70326 | Glucose metabolism | 4.975156e-01 | 0.303 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.977236e-01 | 0.303 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.977236e-01 | 0.303 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.977236e-01 | 0.303 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.009310e-01 | 0.300 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.040988e-01 | 0.297 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.055233e-01 | 0.296 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.055233e-01 | 0.296 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.055233e-01 | 0.296 |
| R-HSA-73893 | DNA Damage Bypass | 5.166086e-01 | 0.287 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.173796e-01 | 0.286 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.173796e-01 | 0.286 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.251788e-01 | 0.280 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.293753e-01 | 0.276 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.347868e-01 | 0.272 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.347868e-01 | 0.272 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.347868e-01 | 0.272 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.381210e-01 | 0.269 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.406937e-01 | 0.267 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.443044e-01 | 0.264 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 5.579704e-01 | 0.253 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.579704e-01 | 0.253 |
| R-HSA-397014 | Muscle contraction | 5.678832e-01 | 0.246 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.691273e-01 | 0.245 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.746003e-01 | 0.241 |
| R-HSA-8979227 | Triglyceride metabolism | 5.746003e-01 | 0.241 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.746003e-01 | 0.241 |
| R-HSA-379724 | tRNA Aminoacylation | 5.800040e-01 | 0.237 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.800040e-01 | 0.237 |
| R-HSA-156590 | Glutathione conjugation | 5.800040e-01 | 0.237 |
| R-HSA-913531 | Interferon Signaling | 5.867298e-01 | 0.232 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.879921e-01 | 0.231 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.879921e-01 | 0.231 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.906075e-01 | 0.229 |
| R-HSA-6807070 | PTEN Regulation | 5.914902e-01 | 0.228 |
| R-HSA-8951664 | Neddylation | 5.936479e-01 | 0.226 |
| R-HSA-8848021 | Signaling by PTK6 | 5.958088e-01 | 0.225 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.958088e-01 | 0.225 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.052618e-01 | 0.218 |
| R-HSA-196807 | Nicotinate metabolism | 6.159649e-01 | 0.210 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.184049e-01 | 0.209 |
| R-HSA-5218859 | Regulated Necrosis | 6.208457e-01 | 0.207 |
| R-HSA-166520 | Signaling by NTRKs | 6.252587e-01 | 0.204 |
| R-HSA-8978934 | Metabolism of cofactors | 6.351206e-01 | 0.197 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.381511e-01 | 0.195 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.397590e-01 | 0.194 |
| R-HSA-4086398 | Ca2+ pathway | 6.443387e-01 | 0.191 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.488605e-01 | 0.188 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.533251e-01 | 0.185 |
| R-HSA-162587 | HIV Life Cycle | 6.537763e-01 | 0.185 |
| R-HSA-168249 | Innate Immune System | 6.537899e-01 | 0.185 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.568364e-01 | 0.183 |
| R-HSA-877300 | Interferon gamma signaling | 6.598750e-01 | 0.181 |
| R-HSA-191273 | Cholesterol biosynthesis | 6.663828e-01 | 0.176 |
| R-HSA-9833482 | PKR-mediated signaling | 6.748148e-01 | 0.171 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.748148e-01 | 0.171 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.789509e-01 | 0.168 |
| R-HSA-5619102 | SLC transporter disorders | 6.834147e-01 | 0.165 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.910478e-01 | 0.160 |
| R-HSA-72306 | tRNA processing | 6.946786e-01 | 0.158 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.949785e-01 | 0.158 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.026911e-01 | 0.153 |
| R-HSA-70268 | Pyruvate metabolism | 7.064743e-01 | 0.151 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 7.223175e-01 | 0.141 |
| R-HSA-391251 | Protein folding | 7.281883e-01 | 0.138 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.281883e-01 | 0.138 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.350650e-01 | 0.134 |
| R-HSA-1474290 | Collagen formation | 7.350650e-01 | 0.134 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 7.384381e-01 | 0.132 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.450567e-01 | 0.128 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.508473e-01 | 0.124 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.554877e-01 | 0.122 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.662658e-01 | 0.116 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.699056e-01 | 0.114 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.699056e-01 | 0.114 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.754605e-01 | 0.110 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.757315e-01 | 0.110 |
| R-HSA-72172 | mRNA Splicing | 7.797017e-01 | 0.108 |
| R-HSA-6805567 | Keratinization | 7.838728e-01 | 0.106 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.001838e-01 | 0.097 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.126023e-01 | 0.090 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.126023e-01 | 0.090 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.126023e-01 | 0.090 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.149922e-01 | 0.089 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.175253e-01 | 0.087 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.206725e-01 | 0.086 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.264946e-01 | 0.083 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.264946e-01 | 0.083 |
| R-HSA-114608 | Platelet degranulation | 8.372851e-01 | 0.077 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.413833e-01 | 0.075 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.434360e-01 | 0.074 |
| R-HSA-9717189 | Sensory perception of taste | 8.474075e-01 | 0.072 |
| R-HSA-9843745 | Adipogenesis | 8.474075e-01 | 0.072 |
| R-HSA-5576891 | Cardiac conduction | 8.474075e-01 | 0.072 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.512788e-01 | 0.070 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.658106e-01 | 0.063 |
| R-HSA-9664407 | Parasite infection | 8.658106e-01 | 0.063 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.658106e-01 | 0.063 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.835120e-01 | 0.054 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.898791e-01 | 0.051 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.942979e-01 | 0.049 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.975037e-01 | 0.047 |
| R-HSA-9658195 | Leishmania infection | 8.975037e-01 | 0.047 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.027191e-01 | 0.044 |
| R-HSA-1483257 | Phospholipid metabolism | 9.113057e-01 | 0.040 |
| R-HSA-418555 | G alpha (s) signalling events | 9.122433e-01 | 0.040 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.122468e-01 | 0.040 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.166514e-01 | 0.038 |
| R-HSA-72766 | Translation | 9.275598e-01 | 0.033 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.276700e-01 | 0.033 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.630482e-01 | 0.016 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.682129e-01 | 0.014 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.695775e-01 | 0.013 |
| R-HSA-5668914 | Diseases of metabolism | 9.788786e-01 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.845615e-01 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 9.880469e-01 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 9.890874e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.904195e-01 | 0.004 |
| R-HSA-109582 | Hemostasis | 9.925030e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.960037e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.960037e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.966920e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.975939e-01 | 0.001 |
| R-HSA-112316 | Neuronal System | 9.982031e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.990085e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.996381e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998693e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999136e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999410e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.832 | 0.148 | 2 | 0.844 |
DSTYK |
0.824 | 0.167 | 2 | 0.867 |
BMPR1B |
0.824 | 0.346 | 1 | 0.760 |
TGFBR1 |
0.821 | 0.388 | -2 | 0.922 |
TGFBR2 |
0.820 | 0.187 | -2 | 0.901 |
FAM20C |
0.817 | 0.184 | 2 | 0.696 |
CK2A2 |
0.817 | 0.491 | 1 | 0.695 |
IKKB |
0.816 | 0.066 | -2 | 0.663 |
CAMK2G |
0.815 | 0.131 | 2 | 0.833 |
CLK3 |
0.815 | 0.082 | 1 | 0.757 |
TBK1 |
0.815 | 0.030 | 1 | 0.791 |
ALK4 |
0.814 | 0.354 | -2 | 0.923 |
ALK2 |
0.814 | 0.373 | -2 | 0.912 |
BMPR1A |
0.813 | 0.335 | 1 | 0.740 |
GRK6 |
0.812 | 0.265 | 1 | 0.808 |
IKKE |
0.812 | 0.027 | 1 | 0.789 |
GCN2 |
0.812 | -0.045 | 2 | 0.748 |
RAF1 |
0.812 | -0.011 | 1 | 0.851 |
NEK6 |
0.812 | 0.054 | -2 | 0.837 |
MOS |
0.811 | 0.055 | 1 | 0.815 |
CDC7 |
0.811 | -0.006 | 1 | 0.795 |
GRK7 |
0.811 | 0.323 | 1 | 0.736 |
BMPR2 |
0.811 | 0.105 | -2 | 0.840 |
PRPK |
0.811 | -0.043 | -1 | 0.823 |
ACVR2A |
0.810 | 0.288 | -2 | 0.882 |
MTOR |
0.810 | -0.023 | 1 | 0.786 |
IKKA |
0.809 | 0.117 | -2 | 0.665 |
NEK7 |
0.809 | 0.012 | -3 | 0.829 |
PLK1 |
0.808 | 0.205 | -2 | 0.824 |
PDHK4 |
0.807 | -0.100 | 1 | 0.845 |
ULK2 |
0.806 | -0.071 | 2 | 0.742 |
PLK3 |
0.806 | 0.211 | 2 | 0.757 |
CAMK2B |
0.805 | 0.163 | 2 | 0.822 |
CK2A1 |
0.805 | 0.446 | 1 | 0.680 |
ACVR2B |
0.805 | 0.254 | -2 | 0.878 |
GRK1 |
0.805 | 0.126 | -2 | 0.716 |
GRK4 |
0.804 | 0.073 | -2 | 0.785 |
PIM3 |
0.804 | 0.011 | -3 | 0.814 |
GRK5 |
0.804 | 0.083 | -3 | 0.860 |
MST4 |
0.804 | 0.020 | 2 | 0.847 |
CAMK1B |
0.804 | -0.019 | -3 | 0.850 |
PDHK1 |
0.804 | -0.052 | 1 | 0.841 |
MLK1 |
0.803 | -0.011 | 2 | 0.793 |
NDR2 |
0.803 | -0.015 | -3 | 0.818 |
HUNK |
0.801 | -0.042 | 2 | 0.746 |
PKN3 |
0.800 | -0.008 | -3 | 0.798 |
ATR |
0.800 | -0.029 | 1 | 0.770 |
KIS |
0.800 | -0.010 | 1 | 0.616 |
LATS2 |
0.800 | 0.039 | -5 | 0.785 |
ATM |
0.799 | 0.051 | 1 | 0.707 |
MARK4 |
0.799 | -0.030 | 4 | 0.858 |
PKCD |
0.799 | 0.022 | 2 | 0.793 |
NLK |
0.798 | -0.077 | 1 | 0.775 |
CAMK2D |
0.798 | 0.031 | -3 | 0.818 |
RSK2 |
0.798 | 0.030 | -3 | 0.750 |
BCKDK |
0.797 | -0.032 | -1 | 0.794 |
NIK |
0.797 | -0.063 | -3 | 0.871 |
TLK2 |
0.797 | 0.141 | 1 | 0.797 |
SKMLCK |
0.796 | -0.028 | -2 | 0.752 |
MAPKAPK2 |
0.796 | 0.082 | -3 | 0.707 |
NUAK2 |
0.796 | -0.046 | -3 | 0.821 |
ANKRD3 |
0.796 | -0.035 | 1 | 0.824 |
WNK1 |
0.796 | -0.071 | -2 | 0.744 |
CDKL1 |
0.795 | -0.040 | -3 | 0.777 |
CAMLCK |
0.795 | -0.040 | -2 | 0.751 |
CAMK2A |
0.795 | 0.111 | 2 | 0.829 |
ULK1 |
0.795 | -0.082 | -3 | 0.806 |
RIPK3 |
0.795 | -0.158 | 3 | 0.347 |
PIM1 |
0.794 | 0.024 | -3 | 0.764 |
NDR1 |
0.794 | -0.063 | -3 | 0.816 |
PRKD1 |
0.794 | -0.041 | -3 | 0.799 |
PKN2 |
0.793 | -0.043 | -3 | 0.823 |
TTBK2 |
0.793 | -0.020 | 2 | 0.660 |
CHAK2 |
0.793 | -0.091 | -1 | 0.813 |
AMPKA1 |
0.793 | -0.039 | -3 | 0.835 |
DAPK2 |
0.792 | -0.055 | -3 | 0.851 |
NEK9 |
0.792 | -0.101 | 2 | 0.789 |
TLK1 |
0.792 | 0.127 | -2 | 0.851 |
MLK3 |
0.792 | 0.005 | 2 | 0.753 |
LATS1 |
0.791 | 0.079 | -3 | 0.832 |
TSSK2 |
0.791 | -0.026 | -5 | 0.857 |
MAPKAPK3 |
0.791 | 0.003 | -3 | 0.750 |
WNK3 |
0.791 | -0.172 | 1 | 0.812 |
DNAPK |
0.791 | 0.058 | 1 | 0.706 |
ERK5 |
0.790 | -0.084 | 1 | 0.710 |
P90RSK |
0.790 | -0.021 | -3 | 0.750 |
DLK |
0.789 | -0.073 | 1 | 0.818 |
PRKD2 |
0.789 | -0.028 | -3 | 0.744 |
YSK4 |
0.789 | -0.002 | 1 | 0.804 |
SRPK1 |
0.789 | -0.033 | -3 | 0.725 |
SRPK2 |
0.788 | -0.008 | -3 | 0.646 |
MLK4 |
0.788 | -0.006 | 2 | 0.700 |
MASTL |
0.787 | -0.209 | -2 | 0.737 |
P70S6KB |
0.787 | -0.035 | -3 | 0.776 |
TSSK1 |
0.787 | -0.047 | -3 | 0.852 |
AURA |
0.786 | 0.024 | -2 | 0.581 |
GRK2 |
0.786 | 0.054 | -2 | 0.688 |
PKR |
0.786 | -0.048 | 1 | 0.799 |
PKACG |
0.786 | -0.037 | -2 | 0.634 |
CDKL5 |
0.785 | -0.061 | -3 | 0.767 |
AMPKA2 |
0.785 | -0.054 | -3 | 0.801 |
RSK3 |
0.785 | -0.044 | -3 | 0.740 |
AURC |
0.785 | -0.008 | -2 | 0.577 |
MEK1 |
0.785 | -0.065 | 2 | 0.800 |
ICK |
0.784 | -0.067 | -3 | 0.814 |
NIM1 |
0.784 | -0.119 | 3 | 0.391 |
MSK2 |
0.784 | -0.023 | -3 | 0.715 |
IRE2 |
0.784 | -0.085 | 2 | 0.720 |
PLK4 |
0.783 | -0.028 | 2 | 0.587 |
MLK2 |
0.783 | -0.152 | 2 | 0.785 |
HIPK4 |
0.783 | -0.090 | 1 | 0.714 |
SRPK3 |
0.783 | -0.034 | -3 | 0.695 |
PKCG |
0.783 | -0.011 | 2 | 0.746 |
IRE1 |
0.783 | -0.140 | 1 | 0.749 |
CLK4 |
0.783 | 0.006 | -3 | 0.752 |
BRAF |
0.782 | 0.025 | -4 | 0.836 |
HRI |
0.782 | -0.030 | -2 | 0.836 |
QSK |
0.782 | -0.059 | 4 | 0.842 |
PHKG1 |
0.782 | -0.061 | -3 | 0.810 |
PERK |
0.782 | -0.004 | -2 | 0.846 |
MARK2 |
0.782 | -0.026 | 4 | 0.771 |
PKCB |
0.781 | -0.016 | 2 | 0.743 |
PKCA |
0.781 | -0.010 | 2 | 0.735 |
PAK6 |
0.781 | 0.010 | -2 | 0.606 |
CDK8 |
0.781 | -0.053 | 1 | 0.602 |
CDK1 |
0.781 | -0.020 | 1 | 0.559 |
DRAK1 |
0.781 | 0.007 | 1 | 0.772 |
CAMK4 |
0.780 | -0.093 | -3 | 0.807 |
PAK1 |
0.780 | -0.034 | -2 | 0.670 |
MARK3 |
0.780 | -0.029 | 4 | 0.796 |
CDK5 |
0.780 | -0.033 | 1 | 0.617 |
RIPK1 |
0.780 | -0.235 | 1 | 0.778 |
PLK2 |
0.780 | 0.140 | -3 | 0.827 |
MEKK3 |
0.780 | -0.043 | 1 | 0.803 |
BRSK1 |
0.779 | -0.042 | -3 | 0.766 |
NEK2 |
0.779 | -0.065 | 2 | 0.758 |
AURB |
0.779 | -0.017 | -2 | 0.582 |
RSK4 |
0.779 | 0.024 | -3 | 0.714 |
NUAK1 |
0.779 | -0.084 | -3 | 0.767 |
QIK |
0.779 | -0.119 | -3 | 0.815 |
PKCH |
0.779 | -0.035 | 2 | 0.717 |
GRK3 |
0.778 | 0.079 | -2 | 0.668 |
MSK1 |
0.778 | -0.001 | -3 | 0.720 |
MEKK1 |
0.778 | -0.090 | 1 | 0.798 |
ZAK |
0.778 | -0.054 | 1 | 0.781 |
MNK2 |
0.777 | -0.066 | -2 | 0.691 |
CHK1 |
0.777 | -0.026 | -3 | 0.807 |
CLK1 |
0.777 | -0.006 | -3 | 0.729 |
MYLK4 |
0.777 | -0.034 | -2 | 0.668 |
PKACB |
0.777 | 0.009 | -2 | 0.586 |
JNK3 |
0.776 | 0.004 | 1 | 0.587 |
PAK3 |
0.776 | -0.091 | -2 | 0.665 |
SMG1 |
0.776 | -0.068 | 1 | 0.723 |
SIK |
0.776 | -0.074 | -3 | 0.741 |
VRK2 |
0.776 | -0.255 | 1 | 0.812 |
MARK1 |
0.775 | -0.051 | 4 | 0.821 |
PAK2 |
0.775 | -0.063 | -2 | 0.666 |
CDK2 |
0.775 | -0.061 | 1 | 0.642 |
MEKK2 |
0.775 | -0.061 | 2 | 0.765 |
JNK2 |
0.774 | 0.000 | 1 | 0.558 |
BRSK2 |
0.774 | -0.095 | -3 | 0.795 |
CLK2 |
0.774 | 0.028 | -3 | 0.729 |
CHAK1 |
0.774 | -0.167 | 2 | 0.722 |
PRKX |
0.773 | 0.029 | -3 | 0.658 |
PKG2 |
0.773 | -0.033 | -2 | 0.569 |
TAO3 |
0.773 | -0.015 | 1 | 0.805 |
DCAMKL1 |
0.773 | -0.018 | -3 | 0.767 |
PRKD3 |
0.773 | -0.069 | -3 | 0.720 |
P38A |
0.773 | -0.044 | 1 | 0.622 |
CDK3 |
0.772 | -0.017 | 1 | 0.493 |
MST3 |
0.772 | -0.021 | 2 | 0.808 |
MELK |
0.772 | -0.125 | -3 | 0.785 |
CK1E |
0.772 | -0.005 | -3 | 0.596 |
PKCZ |
0.771 | -0.107 | 2 | 0.743 |
TTBK1 |
0.771 | -0.053 | 2 | 0.591 |
MEK5 |
0.771 | -0.177 | 2 | 0.782 |
CDK19 |
0.771 | -0.069 | 1 | 0.561 |
NEK5 |
0.771 | -0.088 | 1 | 0.800 |
MST2 |
0.770 | 0.056 | 1 | 0.825 |
SGK3 |
0.770 | -0.026 | -3 | 0.735 |
MNK1 |
0.770 | -0.077 | -2 | 0.695 |
CDK13 |
0.769 | -0.074 | 1 | 0.579 |
DYRK2 |
0.769 | -0.065 | 1 | 0.603 |
PRP4 |
0.769 | -0.035 | -3 | 0.773 |
PHKG2 |
0.769 | -0.063 | -3 | 0.787 |
P38B |
0.769 | -0.025 | 1 | 0.546 |
CDK7 |
0.769 | -0.086 | 1 | 0.606 |
WNK4 |
0.768 | -0.129 | -2 | 0.749 |
AKT2 |
0.768 | -0.032 | -3 | 0.663 |
PINK1 |
0.768 | -0.130 | 1 | 0.778 |
NEK8 |
0.768 | -0.069 | 2 | 0.775 |
CAMK1G |
0.768 | -0.068 | -3 | 0.737 |
CDK18 |
0.768 | -0.049 | 1 | 0.526 |
PKCT |
0.767 | -0.053 | 2 | 0.728 |
DCAMKL2 |
0.767 | -0.039 | -3 | 0.795 |
CK1G1 |
0.767 | -0.021 | -3 | 0.586 |
P38G |
0.767 | -0.016 | 1 | 0.473 |
MAPKAPK5 |
0.767 | -0.111 | -3 | 0.684 |
ERK2 |
0.766 | -0.057 | 1 | 0.596 |
PIM2 |
0.766 | -0.040 | -3 | 0.722 |
ERK1 |
0.766 | -0.045 | 1 | 0.545 |
TAK1 |
0.766 | 0.052 | 1 | 0.853 |
SNRK |
0.766 | -0.198 | 2 | 0.625 |
EEF2K |
0.766 | 0.007 | 3 | 0.421 |
TAO2 |
0.765 | -0.055 | 2 | 0.833 |
GCK |
0.765 | 0.009 | 1 | 0.843 |
SSTK |
0.765 | -0.072 | 4 | 0.845 |
SMMLCK |
0.765 | -0.062 | -3 | 0.796 |
CK1D |
0.765 | 0.001 | -3 | 0.545 |
IRAK4 |
0.764 | -0.171 | 1 | 0.753 |
TNIK |
0.764 | -0.000 | 3 | 0.401 |
PASK |
0.764 | -0.022 | -3 | 0.830 |
PKACA |
0.764 | -0.006 | -2 | 0.536 |
CDK17 |
0.763 | -0.052 | 1 | 0.480 |
CAMK1D |
0.763 | -0.015 | -3 | 0.657 |
GAK |
0.762 | -0.019 | 1 | 0.778 |
MINK |
0.762 | -0.030 | 1 | 0.826 |
CAMKK1 |
0.762 | -0.107 | -2 | 0.655 |
CDK12 |
0.761 | -0.073 | 1 | 0.555 |
MST1 |
0.761 | 0.037 | 1 | 0.816 |
AKT1 |
0.761 | -0.030 | -3 | 0.682 |
HGK |
0.760 | -0.055 | 3 | 0.396 |
PAK5 |
0.760 | -0.033 | -2 | 0.569 |
NEK11 |
0.760 | -0.131 | 1 | 0.815 |
GSK3A |
0.760 | 0.007 | 4 | 0.378 |
DAPK3 |
0.760 | -0.024 | -3 | 0.781 |
HIPK1 |
0.759 | -0.062 | 1 | 0.623 |
PKCE |
0.759 | -0.020 | 2 | 0.730 |
PKCI |
0.759 | -0.081 | 2 | 0.718 |
HIPK2 |
0.759 | -0.046 | 1 | 0.521 |
CDK16 |
0.759 | -0.022 | 1 | 0.495 |
TTK |
0.759 | 0.070 | -2 | 0.856 |
PAK4 |
0.759 | -0.033 | -2 | 0.584 |
IRAK1 |
0.759 | -0.218 | -1 | 0.738 |
CK1A2 |
0.759 | -0.015 | -3 | 0.543 |
MPSK1 |
0.758 | -0.103 | 1 | 0.747 |
DYRK1A |
0.757 | -0.075 | 1 | 0.669 |
NEK4 |
0.757 | -0.122 | 1 | 0.799 |
PDK1 |
0.757 | -0.102 | 1 | 0.787 |
KHS2 |
0.757 | 0.010 | 1 | 0.837 |
P38D |
0.757 | -0.022 | 1 | 0.484 |
HPK1 |
0.757 | -0.023 | 1 | 0.831 |
CDK9 |
0.756 | -0.101 | 1 | 0.585 |
JNK1 |
0.756 | -0.017 | 1 | 0.540 |
CAMKK2 |
0.755 | -0.115 | -2 | 0.648 |
DYRK1B |
0.755 | -0.045 | 1 | 0.570 |
CDK14 |
0.755 | -0.067 | 1 | 0.578 |
KHS1 |
0.754 | -0.013 | 1 | 0.821 |
DYRK4 |
0.754 | -0.044 | 1 | 0.536 |
HIPK3 |
0.753 | -0.097 | 1 | 0.636 |
GSK3B |
0.753 | -0.054 | 4 | 0.369 |
LKB1 |
0.753 | -0.138 | -3 | 0.819 |
DAPK1 |
0.753 | -0.024 | -3 | 0.763 |
RIPK2 |
0.752 | -0.174 | 1 | 0.761 |
P70S6K |
0.752 | -0.085 | -3 | 0.679 |
PDHK3_TYR |
0.752 | 0.160 | 4 | 0.880 |
MAP3K15 |
0.752 | -0.141 | 1 | 0.773 |
VRK1 |
0.751 | -0.149 | 2 | 0.798 |
NEK1 |
0.751 | -0.116 | 1 | 0.781 |
MRCKB |
0.751 | -0.019 | -3 | 0.715 |
PKN1 |
0.751 | -0.071 | -3 | 0.700 |
LOK |
0.750 | -0.095 | -2 | 0.658 |
DYRK3 |
0.749 | -0.063 | 1 | 0.623 |
CHK2 |
0.749 | -0.052 | -3 | 0.613 |
MEK2 |
0.749 | -0.149 | 2 | 0.763 |
SLK |
0.748 | -0.079 | -2 | 0.625 |
MRCKA |
0.748 | -0.030 | -3 | 0.733 |
YSK1 |
0.748 | -0.085 | 2 | 0.773 |
CDK10 |
0.748 | -0.055 | 1 | 0.560 |
MEKK6 |
0.748 | -0.179 | 1 | 0.783 |
ROCK2 |
0.747 | -0.028 | -3 | 0.768 |
LRRK2 |
0.747 | -0.179 | 2 | 0.795 |
PDHK4_TYR |
0.747 | 0.141 | 2 | 0.851 |
ERK7 |
0.747 | -0.069 | 2 | 0.473 |
OSR1 |
0.747 | -0.024 | 2 | 0.746 |
SGK1 |
0.746 | -0.015 | -3 | 0.581 |
CAMK1A |
0.746 | -0.045 | -3 | 0.630 |
PDHK1_TYR |
0.745 | 0.115 | -1 | 0.869 |
MAP2K6_TYR |
0.745 | 0.105 | -1 | 0.849 |
AKT3 |
0.744 | -0.036 | -3 | 0.597 |
CDK6 |
0.744 | -0.076 | 1 | 0.556 |
STK33 |
0.743 | -0.155 | 2 | 0.585 |
MAP2K4_TYR |
0.742 | 0.020 | -1 | 0.855 |
TESK1_TYR |
0.742 | -0.057 | 3 | 0.453 |
MAP2K7_TYR |
0.741 | 0.003 | 2 | 0.829 |
CDK4 |
0.741 | -0.077 | 1 | 0.542 |
BMPR2_TYR |
0.741 | 0.039 | -1 | 0.831 |
DMPK1 |
0.740 | -0.017 | -3 | 0.743 |
PINK1_TYR |
0.738 | -0.071 | 1 | 0.804 |
NEK3 |
0.738 | -0.175 | 1 | 0.754 |
MYO3A |
0.737 | -0.055 | 1 | 0.795 |
EPHA6 |
0.737 | -0.009 | -1 | 0.856 |
TAO1 |
0.736 | -0.076 | 1 | 0.758 |
MAK |
0.736 | -0.045 | -2 | 0.604 |
RET |
0.736 | -0.072 | 1 | 0.780 |
TXK |
0.735 | 0.072 | 1 | 0.785 |
ALPHAK3 |
0.735 | -0.021 | -1 | 0.757 |
SBK |
0.735 | -0.027 | -3 | 0.542 |
YES1 |
0.735 | -0.009 | -1 | 0.840 |
BUB1 |
0.735 | -0.079 | -5 | 0.801 |
PKG1 |
0.735 | -0.071 | -2 | 0.498 |
MYO3B |
0.734 | -0.089 | 2 | 0.790 |
PKMYT1_TYR |
0.734 | -0.161 | 3 | 0.431 |
ROCK1 |
0.734 | -0.042 | -3 | 0.734 |
INSRR |
0.734 | -0.024 | 3 | 0.365 |
ASK1 |
0.733 | -0.116 | 1 | 0.762 |
TYK2 |
0.733 | -0.125 | 1 | 0.783 |
CSF1R |
0.733 | -0.090 | 3 | 0.372 |
HASPIN |
0.733 | -0.061 | -1 | 0.656 |
EPHB4 |
0.732 | -0.052 | -1 | 0.855 |
ROS1 |
0.731 | -0.134 | 3 | 0.360 |
FER |
0.731 | -0.045 | 1 | 0.794 |
FGR |
0.731 | -0.060 | 1 | 0.789 |
MST1R |
0.731 | -0.159 | 3 | 0.384 |
YANK3 |
0.731 | -0.061 | 2 | 0.395 |
JAK2 |
0.731 | -0.135 | 1 | 0.776 |
LIMK2_TYR |
0.730 | -0.123 | -3 | 0.879 |
BLK |
0.730 | 0.006 | -1 | 0.824 |
BIKE |
0.730 | -0.044 | 1 | 0.647 |
ABL2 |
0.730 | -0.063 | -1 | 0.814 |
HCK |
0.730 | -0.058 | -1 | 0.810 |
PBK |
0.730 | -0.120 | 1 | 0.701 |
EPHA4 |
0.730 | -0.001 | 2 | 0.759 |
TYRO3 |
0.729 | -0.153 | 3 | 0.375 |
CK1A |
0.729 | -0.014 | -3 | 0.458 |
MOK |
0.729 | -0.076 | 1 | 0.609 |
SRMS |
0.728 | -0.014 | 1 | 0.790 |
STLK3 |
0.728 | -0.072 | 1 | 0.763 |
LCK |
0.728 | -0.034 | -1 | 0.804 |
JAK3 |
0.727 | -0.096 | 1 | 0.765 |
EPHB1 |
0.727 | -0.046 | 1 | 0.786 |
EPHB2 |
0.727 | -0.018 | -1 | 0.842 |
KIT |
0.726 | -0.082 | 3 | 0.377 |
DDR1 |
0.725 | -0.138 | 4 | 0.831 |
LIMK1_TYR |
0.725 | -0.190 | 2 | 0.821 |
FGFR2 |
0.725 | -0.082 | 3 | 0.390 |
TEC |
0.724 | -0.009 | -1 | 0.762 |
EPHB3 |
0.724 | -0.058 | -1 | 0.844 |
ITK |
0.724 | -0.055 | -1 | 0.790 |
FYN |
0.724 | 0.013 | -1 | 0.773 |
FLT3 |
0.723 | -0.122 | 3 | 0.368 |
CRIK |
0.723 | -0.060 | -3 | 0.673 |
KDR |
0.723 | -0.101 | 3 | 0.352 |
ABL1 |
0.723 | -0.098 | -1 | 0.811 |
PDGFRB |
0.723 | -0.141 | 3 | 0.379 |
JAK1 |
0.722 | -0.090 | 1 | 0.759 |
LYN |
0.721 | -0.052 | 3 | 0.349 |
NEK10_TYR |
0.721 | -0.062 | 1 | 0.715 |
MERTK |
0.720 | -0.072 | 3 | 0.370 |
FLT1 |
0.720 | -0.022 | -1 | 0.836 |
TNK2 |
0.720 | -0.148 | 3 | 0.369 |
FGFR1 |
0.720 | -0.126 | 3 | 0.382 |
ERBB2 |
0.720 | -0.070 | 1 | 0.747 |
EPHA7 |
0.719 | -0.045 | 2 | 0.749 |
BTK |
0.719 | -0.115 | -1 | 0.762 |
ALK |
0.719 | -0.118 | 3 | 0.355 |
CK1G3 |
0.718 | -0.003 | -3 | 0.407 |
MET |
0.718 | -0.099 | 3 | 0.370 |
FRK |
0.717 | -0.065 | -1 | 0.841 |
FGFR3 |
0.717 | -0.077 | 3 | 0.377 |
TEK |
0.717 | -0.166 | 3 | 0.354 |
TNNI3K_TYR |
0.717 | -0.095 | 1 | 0.762 |
AXL |
0.717 | -0.139 | 3 | 0.370 |
BMX |
0.716 | -0.061 | -1 | 0.701 |
EGFR |
0.716 | 0.017 | 1 | 0.651 |
NTRK1 |
0.716 | -0.111 | -1 | 0.813 |
LTK |
0.716 | -0.124 | 3 | 0.367 |
EPHA3 |
0.716 | -0.079 | 2 | 0.732 |
SRC |
0.716 | -0.031 | -1 | 0.794 |
EPHA5 |
0.715 | -0.022 | 2 | 0.748 |
INSR |
0.715 | -0.104 | 3 | 0.352 |
PDGFRA |
0.715 | -0.201 | 3 | 0.371 |
TNK1 |
0.714 | -0.174 | 3 | 0.368 |
FLT4 |
0.714 | -0.115 | 3 | 0.357 |
PTK6 |
0.714 | -0.092 | -1 | 0.733 |
EPHA8 |
0.713 | -0.037 | -1 | 0.812 |
NTRK2 |
0.712 | -0.138 | 3 | 0.345 |
PTK2B |
0.712 | -0.040 | -1 | 0.792 |
EPHA1 |
0.712 | -0.128 | 3 | 0.355 |
WEE1_TYR |
0.711 | -0.112 | -1 | 0.720 |
AAK1 |
0.711 | -0.024 | 1 | 0.538 |
FGFR4 |
0.711 | -0.029 | -1 | 0.782 |
PTK2 |
0.711 | 0.029 | -1 | 0.761 |
NTRK3 |
0.710 | -0.094 | -1 | 0.760 |
SYK |
0.708 | 0.031 | -1 | 0.748 |
DDR2 |
0.708 | -0.107 | 3 | 0.368 |
IGF1R |
0.707 | -0.071 | 3 | 0.328 |
CSK |
0.706 | -0.093 | 2 | 0.749 |
MATK |
0.706 | -0.094 | -1 | 0.742 |
EPHA2 |
0.703 | -0.044 | -1 | 0.775 |
ERBB4 |
0.701 | -0.032 | 1 | 0.657 |
YANK2 |
0.700 | -0.076 | 2 | 0.416 |
CK1G2 |
0.700 | -0.028 | -3 | 0.503 |
MUSK |
0.692 | -0.131 | 1 | 0.640 |
FES |
0.689 | -0.099 | -1 | 0.691 |
ZAP70 |
0.679 | -0.061 | -1 | 0.643 |