Motif 661 (n=214)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6H8Y1 | BDP1 | S938 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NDB9 | PALM3 | S548 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A7KAX9 | ARHGAP32 | S43 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7KAX9 | ARHGAP32 | S44 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O00161 | SNAP23 | S161 | ochoa|psp | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O00472 | ELL2 | S604 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O14519 | CDK2AP1 | S84 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O15042 | U2SURP | S811 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O43491 | EPB41L2 | S715 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43719 | HTATSF1 | S521 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43719 | HTATSF1 | S579 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60216 | RAD21 | S454 | ochoa|psp | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
| O60264 | SMARCA5 | S710 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60524 | NEMF | S763 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60716 | CTNND1 | S122 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75152 | ZC3H11A | S781 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75334 | PPFIA2 | S687 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
| O75427 | LRCH4 | S380 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75691 | UTP20 | S783 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95235 | KIF20A | S632 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95453 | PARN | S587 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95714 | HERC2 | S1577 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95714 | HERC2 | S1588 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P02730 | SLC4A1 | Y21 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P05060 | CHGB | S391 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P07951 | TPM2 | S158 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P08708 | RPS17 | S89 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P10244 | MYBL2 | S251 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P11055 | MYH3 | T938 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11388 | TOP2A | S1117 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12270 | TPR | S1459 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12830 | CDH1 | S770 | ochoa | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P12882 | MYH1 | T941 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T937 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T939 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P16220 | CREB1 | S107 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
| P19022 | CDH2 | S788 | ochoa | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. {ECO:0000250|UniProtKB:P10288, ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:31585109}. |
| P19338 | NCL | S460 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P21817 | RYR1 | S2843 | ochoa|psp | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P23443 | RPS6KB1 | S53 | psp | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P23497 | SP100 | S171 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P25490 | YY1 | S247 | ochoa|psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P28370 | SMARCA1 | S725 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) | [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}. |
| P38398 | BRCA1 | T1548 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41227 | NAA10 | S205 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P43487 | RANBP1 | S21 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P50579 | METAP2 | S74 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P50851 | LRBA | S1100 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51003 | PAPOLA | S681 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P52948 | NUP98 | S714 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54760 | EPHB4 | S613 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P55895 | RAG2 | S365 | psp | V(D)J recombination-activating protein 2 (RAG-2) | Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). {ECO:0000250}. |
| P80723 | BASP1 | S40 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| Q00987 | MDM2 | S425 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02156 | PRKCE | S368 | ochoa|psp | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q02447 | SP3 | S566 | ochoa|psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q02952 | AKAP12 | S253 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S640 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03252 | LMNB2 | S90 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q03468 | ERCC6 | S35 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q06546 | GABPA | S26 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
| Q07157 | TJP1 | S381 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | S148 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0ZGT2 | NEXN | S569 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12830 | BPTF | S1673 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12846 | STX4 | S117 | ochoa | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850, ECO:0000269|PubMed:36355422}. |
| Q12873 | CHD3 | S330 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S232 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13107 | USP4 | S675 | ochoa | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) | Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16339847, PubMed:16472766, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766, PubMed:30514904). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (PubMed:30514904). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:22347420, ECO:0000269|PubMed:25404403, ECO:0000269|PubMed:28604766, ECO:0000269|PubMed:30514904}. |
| Q13112 | CHAF1B | S538 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13309 | SKP2 | S57 | ochoa | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13459 | MYO9B | S2002 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13523 | PRP4K | S606 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13546 | RIPK1 | S262 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13823 | GNL2 | S580 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q14151 | SAFB2 | S109 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q147X3 | NAA30 | S55 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14966 | ZNF638 | S1641 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15052 | ARHGEF6 | S649 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15061 | WDR43 | T656 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15147 | PLCB4 | S521 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q16891 | IMMT | S447 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q4G0X9 | CCDC40 | S267 | ochoa | Coiled-coil domain-containing protein 40 | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}. |
| Q4KWH8 | PLCH1 | S464 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q4VC05 | BCL7A | S154 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q562F6 | SGO2 | S509 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JRA6 | MIA3 | S191 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JRA6 | MIA3 | S891 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5QJE6 | DNTTIP2 | S145 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SSJ5 | HP1BP3 | S74 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T200 | ZC3H13 | S1452 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5UIP0 | RIF1 | S1893 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1952 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUA4 | ZNF318 | S1238 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUA4 | ZNF318 | S1761 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q63HN8 | RNF213 | S3494 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q676U5 | ATG16L1 | S248 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6JBY9 | RCSD1 | S333 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NXG1 | ESRP1 | S74 | ochoa | Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}. |
| Q6P996 | PDXDC1 | S30 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PKG0 | LARP1 | S700 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZUJ8 | PIK3AP1 | S421 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q71RC2 | LARP4 | S75 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q76FK4 | NOL8 | S1099 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z401 | DENND4A | S1199 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q86US8 | SMG6 | S85 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UU1 | PHLDB1 | S692 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UU1 | PHLDB1 | S693 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UU1 | PHLDB1 | T697 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86VM9 | ZC3H18 | S173 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86W92 | PPFIBP1 | S965 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IVF2 | AHNAK2 | S375 | ochoa | Protein AHNAK2 | None |
| Q8IWZ8 | SUGP1 | S181 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IX12 | CCAR1 | S994 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8IY92 | SLX4 | S1172 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IY92 | SLX4 | S1185 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N3F8 | MICALL1 | S443 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4C6 | NIN | S1306 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N4X5 | AFAP1L2 | S158 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N9T8 | KRI1 | S141 | ochoa | Protein KRI1 homolog | None |
| Q8NBP7 | PCSK9 | S47 | ochoa|psp | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}. |
| Q8NBR6 | MINDY2 | S233 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8NEV4 | MYO3A | S73 | psp | Myosin-IIIa (EC 2.7.11.1) | Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:12032315, PubMed:29880844, PubMed:34788109). Probably also plays a role in vision. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:29880844, PubMed:34788109). {ECO:0000250|UniProtKB:Q8K3H5, ECO:0000269|PubMed:12032315, ECO:0000269|PubMed:29880844, ECO:0000269|PubMed:34788109}. |
| Q8NFC6 | BOD1L1 | S262 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NG31 | KNL1 | S1773 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NI35 | PATJ | S788 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TCU6 | PREX1 | S1165 | ochoa|psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TCU6 | PREX1 | S1272 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TD43 | TRPM4 | S728 | ochoa | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}. |
| Q8TDJ6 | DMXL2 | S1984 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEW0 | PARD3 | S962 | ochoa|psp | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WU90 | ZC3H15 | T315 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q92610 | ZNF592 | S1227 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92614 | MYO18A | S1309 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92889 | ERCC4 | S519 | ochoa | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}. |
| Q92922 | SMARCC1 | S825 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q969F1 | GTF3C6 | S174 | ochoa | General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}. |
| Q969G3 | SMARCE1 | S314 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96F86 | EDC3 | S233 | ochoa | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96JB3 | HIC2 | S481 | ochoa | Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) | Transcriptional repressor. |
| Q96JG6 | VPS50 | S541 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
| Q96Q07 | BTBD9 | S577 | ochoa | BTB/POZ domain-containing protein 9 | None |
| Q96RL7 | VPS13A | S849 | ochoa | Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:34830155}. |
| Q96RS6 | NUDCD1 | S270 | ochoa | NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) | None |
| Q96SI9 | STRBP | S147 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
| Q96ST2 | IWS1 | S449 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96T23 | RSF1 | S1189 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q9BQG0 | MYBBP1A | S792 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BVR0 | HERC2P3 | S304 | ochoa | Putative HERC2-like protein 3 | None |
| Q9BVR0 | HERC2P3 | S315 | ochoa | Putative HERC2-like protein 3 | None |
| Q9BVS4 | RIOK2 | S390 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BWH6 | RPAP1 | S286 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BXK5 | BCL2L13 | S426 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXP5 | SRRT | S580 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BYV8 | CEP41 | S99 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
| Q9BYV9 | BACH2 | S294 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9BYW2 | SETD2 | S1992 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZF1 | OSBPL8 | S353 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0C9 | UBE2O | S441 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0D0 | PHACTR1 | S187 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0G0 | ZNF407 | S937 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H0E9 | BRD8 | S641 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H0G5 | NSRP1 | S254 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H1H9 | KIF13A | S1545 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H2G2 | SLK | S518 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2J4 | PDCL3 | S43 | ochoa | Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1) | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}. |
| Q9H7L9 | SUDS3 | S39 | ochoa | Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog) | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}. |
| Q9H987 | SYNPO2L | S345 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HB96 | FANCE | S238 | ochoa | Fanconi anemia group E protein (Protein FACE) | As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. {ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:17296736}. |
| Q9NVR5 | DNAAF2 | S773 | ochoa | Protein kintoun (Dynein assembly factor 2, axonemal) | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}. |
| Q9NVU7 | SDAD1 | S595 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NWQ8 | PAG1 | S282 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NWQ8 | PAG1 | S288 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NY61 | AATF | S189 | psp | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYF8 | BCLAF1 | S183 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZ53 | PODXL2 | S195 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9P0P8 | MTRES1 | S116 | ochoa | Mitochondrial transcription rescue factor 1 | Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:31396629, PubMed:33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629, ECO:0000269|PubMed:33243891}. |
| Q9P2D1 | CHD7 | S2251 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2D1 | CHD7 | S2254 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBT2 | UBA2 | S507 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UEE9 | CFDP1 | S102 | ochoa | Craniofacial development protein 1 (Bucentaur) | May play a role during embryogenesis. {ECO:0000250}. |
| Q9UHX1 | PUF60 | S435 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UIG0 | BAZ1B | S716 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UIS9 | MBD1 | S557 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UKX2 | MYH2 | T943 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UL42 | PNMA2 | S345 | ochoa | Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2) | None |
| Q9ULL1 | PLEKHG1 | S1290 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UNX4 | WDR3 | S726 | ochoa | WD repeat-containing protein 3 | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q9UPZ3 | HPS5 | S701 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9Y450 | HBS1L | S67 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y520 | PRRC2C | S848 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y623 | MYH4 | T941 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| O60841 | EIF5B | S178 | Sugiyama | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| P23588 | EIF4B | S122 | Sugiyama | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P35579 | MYH9 | S1892 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P11413 | G6PD | S106 | Sugiyama | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P55072 | VCP | S718 | Sugiyama | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q9BQ39 | DDX50 | S140 | Sugiyama | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q14320 | FAM50A | S50 | Sugiyama | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| O43852 | CALU | S219 | Sugiyama | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| P07814 | EPRS1 | S1029 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| Q9BRS2 | RIOK1 | S507 | Sugiyama | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}. |
| P23443 | RPS6KB1 | S75 | Sugiyama | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| Q14257 | RCN2 | S298 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| Q07666 | KHDRBS1 | S150 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| P35579 | MYH9 | S96 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | S100 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| O43707 | ACTN4 | S796 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| Q969G3 | SMARCE1 | S262 | Sugiyama | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q5VT25 | CDC42BPA | S507 | Sugiyama | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q15751 | HERC1 | S2436 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q13617 | CUL2 | S230 | Sugiyama | Cullin-2 (CUL-2) | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:38326650). CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme (PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655, PubMed:9122164, PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346, PubMed:38326650). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:10973499, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:9122164, PubMed:38326650). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:10973499, PubMed:9122164). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:Q9D4H8, ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:9122164}. |
| Q15382 | RHEB | S140 | Sugiyama | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q8TF76 | HASPIN | S543 | Sugiyama | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8953854 | Metabolism of RNA | 0.000008 | 5.080 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000022 | 4.665 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.000135 | 3.871 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000443 | 3.354 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.000320 | 3.495 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.000451 | 3.345 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000538 | 3.269 |
| R-HSA-1640170 | Cell Cycle | 0.001275 | 2.895 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.002093 | 2.679 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.002093 | 2.679 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.002437 | 2.613 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.001671 | 2.777 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.001845 | 2.734 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.001845 | 2.734 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.002229 | 2.652 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.002229 | 2.652 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.002440 | 2.613 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.002440 | 2.613 |
| R-HSA-1538133 | G0 and Early G1 | 0.002030 | 2.692 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.002542 | 2.595 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.002665 | 2.574 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.002904 | 2.537 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.002817 | 2.550 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.003075 | 2.512 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.003225 | 2.491 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.003424 | 2.465 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004004 | 2.397 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.004318 | 2.365 |
| R-HSA-72172 | mRNA Splicing | 0.004256 | 2.371 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.004091 | 2.388 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.004318 | 2.365 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.004004 | 2.397 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.004648 | 2.333 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.005227 | 2.282 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.005077 | 2.294 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.005628 | 2.250 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005631 | 2.249 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.007126 | 2.147 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.006552 | 2.184 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007063 | 2.151 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.006552 | 2.184 |
| R-HSA-73894 | DNA Repair | 0.006997 | 2.155 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.006986 | 2.156 |
| R-HSA-1500931 | Cell-Cell communication | 0.007488 | 2.126 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.007911 | 2.102 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.007929 | 2.101 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.008638 | 2.064 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.008641 | 2.063 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.009385 | 2.028 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.009385 | 2.028 |
| R-HSA-446728 | Cell junction organization | 0.008988 | 2.046 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.010362 | 1.985 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.010362 | 1.985 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.010565 | 1.976 |
| R-HSA-421270 | Cell-cell junction organization | 0.013695 | 1.863 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.013059 | 1.884 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.014215 | 1.847 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.014436 | 1.841 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.014436 | 1.841 |
| R-HSA-191859 | snRNP Assembly | 0.014436 | 1.841 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.016338 | 1.787 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.015157 | 1.819 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.015900 | 1.799 |
| R-HSA-390522 | Striated Muscle Contraction | 0.018433 | 1.734 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.018304 | 1.737 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.018588 | 1.731 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.016711 | 1.777 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.018588 | 1.731 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.016944 | 1.771 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.016666 | 1.778 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.021713 | 1.663 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.023452 | 1.630 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.025791 | 1.589 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.025606 | 1.592 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.024605 | 1.609 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.022763 | 1.643 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.025476 | 1.594 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.025476 | 1.594 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.026059 | 1.584 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.027198 | 1.565 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.027198 | 1.565 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.028754 | 1.541 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.030829 | 1.511 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.031603 | 1.500 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.031438 | 1.503 |
| R-HSA-165159 | MTOR signalling | 0.032611 | 1.487 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.031603 | 1.500 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.031603 | 1.500 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.031603 | 1.500 |
| R-HSA-74160 | Gene expression (Transcription) | 0.036242 | 1.441 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.035968 | 1.444 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.032355 | 1.490 |
| R-HSA-5693538 | Homology Directed Repair | 0.037191 | 1.430 |
| R-HSA-774815 | Nucleosome assembly | 0.037710 | 1.424 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.037710 | 1.424 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.037710 | 1.424 |
| R-HSA-5688426 | Deubiquitination | 0.038276 | 1.417 |
| R-HSA-3371556 | Cellular response to heat stress | 0.040294 | 1.395 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.040519 | 1.392 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.050640 | 1.296 |
| R-HSA-9766229 | Degradation of CDH1 | 0.045102 | 1.346 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.051484 | 1.288 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.051484 | 1.288 |
| R-HSA-418990 | Adherens junctions interactions | 0.048411 | 1.315 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.047235 | 1.326 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.043550 | 1.361 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.047235 | 1.326 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.047235 | 1.326 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.054129 | 1.267 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.054129 | 1.267 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.055118 | 1.259 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.057702 | 1.239 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.057702 | 1.239 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.059618 | 1.225 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.059672 | 1.224 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.061353 | 1.212 |
| R-HSA-429947 | Deadenylation of mRNA | 0.065082 | 1.187 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.076701 | 1.115 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.061851 | 1.209 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.064921 | 1.188 |
| R-HSA-420029 | Tight junction interactions | 0.068885 | 1.162 |
| R-HSA-3295583 | TRP channels | 0.072759 | 1.138 |
| R-HSA-72312 | rRNA processing | 0.061806 | 1.209 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.076701 | 1.115 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.072437 | 1.140 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.076041 | 1.119 |
| R-HSA-70171 | Glycolysis | 0.068841 | 1.162 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.068885 | 1.162 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.072437 | 1.140 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.072150 | 1.142 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.072150 | 1.142 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.071612 | 1.145 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.078239 | 1.107 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.078988 | 1.102 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.079403 | 1.100 |
| R-HSA-191650 | Regulation of gap junction activity | 0.079403 | 1.100 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.079403 | 1.100 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.104450 | 0.981 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.104450 | 0.981 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.104450 | 0.981 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.106011 | 0.975 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.088915 | 1.051 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.106011 | 0.975 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.101657 | 0.993 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.101657 | 0.993 |
| R-HSA-9930044 | Nuclear RNA decay | 0.101657 | 0.993 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.084782 | 1.072 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.092013 | 1.036 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.088915 | 1.051 |
| R-HSA-73887 | Death Receptor Signaling | 0.091218 | 1.040 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.092914 | 1.032 |
| R-HSA-4839726 | Chromatin organization | 0.080849 | 1.092 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.105337 | 0.977 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.092167 | 1.035 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.104450 | 0.981 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.104450 | 0.981 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.104450 | 0.981 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.097355 | 1.012 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.101657 | 0.993 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.101657 | 0.993 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.102511 | 0.989 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.102511 | 0.989 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.088915 | 1.051 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.097355 | 1.012 |
| R-HSA-162587 | HIV Life Cycle | 0.096355 | 1.016 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.091218 | 1.040 |
| R-HSA-9679506 | SARS-CoV Infections | 0.103763 | 0.984 |
| R-HSA-211000 | Gene Silencing by RNA | 0.083782 | 1.077 |
| R-HSA-68886 | M Phase | 0.107741 | 0.968 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.108885 | 0.963 |
| R-HSA-70326 | Glucose metabolism | 0.108885 | 0.963 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.110414 | 0.957 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.128819 | 0.890 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.128819 | 0.890 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.152527 | 0.817 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.164140 | 0.785 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.151931 | 0.818 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.141471 | 0.849 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.141471 | 0.849 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.164140 | 0.785 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.167543 | 0.776 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.119360 | 0.923 |
| R-HSA-199920 | CREB phosphorylation | 0.116718 | 0.933 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.125941 | 0.900 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.119360 | 0.923 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.119360 | 0.923 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.133099 | 0.876 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.117926 | 0.928 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.171244 | 0.766 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.142448 | 0.846 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.125941 | 0.900 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.128819 | 0.890 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.140754 | 0.852 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.164140 | 0.785 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.137756 | 0.861 |
| R-HSA-68877 | Mitotic Prometaphase | 0.170744 | 0.768 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.128819 | 0.890 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.140754 | 0.852 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.152527 | 0.817 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.164140 | 0.785 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.123899 | 0.907 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.116939 | 0.932 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.128120 | 0.892 |
| R-HSA-5689877 | Josephin domain DUBs | 0.164140 | 0.785 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.151931 | 0.818 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.164140 | 0.785 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.166377 | 0.779 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.161534 | 0.792 |
| R-HSA-168255 | Influenza Infection | 0.140349 | 0.853 |
| R-HSA-597592 | Post-translational protein modification | 0.169448 | 0.771 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.140754 | 0.852 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.138315 | 0.859 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.141030 | 0.851 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.133099 | 0.876 |
| R-HSA-68875 | Mitotic Prophase | 0.115636 | 0.937 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.165623 | 0.781 |
| R-HSA-75153 | Apoptotic execution phase | 0.171244 | 0.766 |
| R-HSA-72306 | tRNA processing | 0.122198 | 0.913 |
| R-HSA-5619102 | SLC transporter disorders | 0.114508 | 0.941 |
| R-HSA-72766 | Translation | 0.171684 | 0.765 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.175593 | 0.755 |
| R-HSA-425381 | Bicarbonate transporters | 0.175593 | 0.755 |
| R-HSA-9635465 | Suppression of apoptosis | 0.175593 | 0.755 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.175593 | 0.755 |
| R-HSA-9609690 | HCMV Early Events | 0.177570 | 0.751 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.198034 | 0.703 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.230561 | 0.637 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.230561 | 0.637 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.251512 | 0.599 |
| R-HSA-3928664 | Ephrin signaling | 0.271895 | 0.566 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.281879 | 0.550 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.281879 | 0.550 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.291726 | 0.535 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.291726 | 0.535 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.291726 | 0.535 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.291726 | 0.535 |
| R-HSA-72187 | mRNA 3'-end processing | 0.200890 | 0.697 |
| R-HSA-1221632 | Meiotic synapsis | 0.205891 | 0.686 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.205891 | 0.686 |
| R-HSA-72649 | Translation initiation complex formation | 0.210905 | 0.676 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.348049 | 0.458 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.220969 | 0.656 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.231071 | 0.636 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.230437 | 0.637 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.291994 | 0.535 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.241202 | 0.618 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.317275 | 0.499 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.181071 | 0.742 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.198034 | 0.703 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.320468 | 0.494 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.320468 | 0.494 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.302126 | 0.520 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.261774 | 0.582 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.267067 | 0.573 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.251512 | 0.599 |
| R-HSA-75893 | TNF signaling | 0.220969 | 0.656 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.276764 | 0.558 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.198376 | 0.703 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.267067 | 0.573 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.219636 | 0.658 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.241108 | 0.618 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.230561 | 0.637 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.271895 | 0.566 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.231071 | 0.636 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.246276 | 0.609 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.297062 | 0.527 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.297062 | 0.527 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.271895 | 0.566 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.297062 | 0.527 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.329788 | 0.482 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.271895 | 0.566 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.320468 | 0.494 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.215932 | 0.666 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.243769 | 0.613 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.251512 | 0.599 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.281879 | 0.550 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.301439 | 0.521 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.338981 | 0.470 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.338981 | 0.470 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.301439 | 0.521 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.231981 | 0.635 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.241202 | 0.618 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.302126 | 0.520 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.281879 | 0.550 |
| R-HSA-8964038 | LDL clearance | 0.320468 | 0.494 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.342345 | 0.466 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.198034 | 0.703 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.338044 | 0.471 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.241108 | 0.618 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.234060 | 0.631 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.307183 | 0.513 |
| R-HSA-9609646 | HCMV Infection | 0.316626 | 0.499 |
| R-HSA-112043 | PLC beta mediated events | 0.246276 | 0.609 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.271895 | 0.566 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.198034 | 0.703 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.209026 | 0.680 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.302126 | 0.520 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.230437 | 0.637 |
| R-HSA-9659379 | Sensory processing of sound | 0.337352 | 0.472 |
| R-HSA-112040 | G-protein mediated events | 0.276764 | 0.558 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.281879 | 0.550 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.281844 | 0.550 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.274482 | 0.561 |
| R-HSA-392499 | Metabolism of proteins | 0.346981 | 0.460 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.281879 | 0.550 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.348049 | 0.458 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.220969 | 0.656 |
| R-HSA-69481 | G2/M Checkpoints | 0.311809 | 0.506 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.356003 | 0.449 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.198034 | 0.703 |
| R-HSA-8876725 | Protein methylation | 0.230561 | 0.637 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.251512 | 0.599 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.281879 | 0.550 |
| R-HSA-9610379 | HCMV Late Events | 0.223236 | 0.651 |
| R-HSA-73886 | Chromosome Maintenance | 0.285642 | 0.544 |
| R-HSA-9842663 | Signaling by LTK | 0.198034 | 0.703 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.230561 | 0.637 |
| R-HSA-9678110 | Attachment and Entry | 0.241108 | 0.618 |
| R-HSA-9629569 | Protein hydroxylation | 0.291726 | 0.535 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.322309 | 0.492 |
| R-HSA-180292 | GAB1 signalosome | 0.271895 | 0.566 |
| R-HSA-9694614 | Attachment and Entry | 0.311019 | 0.507 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.271895 | 0.566 |
| R-HSA-373753 | Nephrin family interactions | 0.291726 | 0.535 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.348049 | 0.458 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.332348 | 0.478 |
| R-HSA-2262752 | Cellular responses to stress | 0.267583 | 0.573 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.208002 | 0.682 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.332348 | 0.478 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.241202 | 0.618 |
| R-HSA-449836 | Other interleukin signaling | 0.281879 | 0.550 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.208815 | 0.680 |
| R-HSA-162906 | HIV Infection | 0.255923 | 0.592 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.276820 | 0.558 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.200890 | 0.697 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.194883 | 0.710 |
| R-HSA-913531 | Interferon Signaling | 0.324061 | 0.489 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.348049 | 0.458 |
| R-HSA-2028269 | Signaling by Hippo | 0.261774 | 0.582 |
| R-HSA-373755 | Semaphorin interactions | 0.256434 | 0.591 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.356993 | 0.447 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.356993 | 0.447 |
| R-HSA-525793 | Myogenesis | 0.356993 | 0.447 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.356993 | 0.447 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.356993 | 0.447 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.356993 | 0.447 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.356993 | 0.447 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.356993 | 0.447 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.362192 | 0.441 |
| R-HSA-8949613 | Cristae formation | 0.365814 | 0.437 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.365814 | 0.437 |
| R-HSA-1500620 | Meiosis | 0.367120 | 0.435 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.367120 | 0.435 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.367952 | 0.434 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.367952 | 0.434 |
| R-HSA-9664407 | Parasite infection | 0.367952 | 0.434 |
| R-HSA-1632852 | Macroautophagy | 0.371677 | 0.430 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.371677 | 0.430 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.374515 | 0.427 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.376931 | 0.424 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.376931 | 0.424 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.382368 | 0.418 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.383097 | 0.417 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.383097 | 0.417 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.383097 | 0.417 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.391528 | 0.407 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.391562 | 0.407 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.391562 | 0.407 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.391562 | 0.407 |
| R-HSA-397014 | Muscle contraction | 0.397444 | 0.401 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.399912 | 0.398 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.399912 | 0.398 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.399912 | 0.398 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.401175 | 0.397 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.401175 | 0.397 |
| R-HSA-69242 | S Phase | 0.401310 | 0.397 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.408661 | 0.389 |
| R-HSA-68882 | Mitotic Anaphase | 0.409794 | 0.387 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.412874 | 0.384 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.416270 | 0.381 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.416270 | 0.381 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.416270 | 0.381 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.416270 | 0.381 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.416270 | 0.381 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.416270 | 0.381 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.416270 | 0.381 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.416270 | 0.381 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.416270 | 0.381 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.424281 | 0.372 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.424281 | 0.372 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.424281 | 0.372 |
| R-HSA-8951664 | Neddylation | 0.425158 | 0.371 |
| R-HSA-9612973 | Autophagy | 0.430545 | 0.366 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.432184 | 0.364 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.432184 | 0.364 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.432184 | 0.364 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.432184 | 0.364 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.432184 | 0.364 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.432184 | 0.364 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.438446 | 0.358 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.439978 | 0.357 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.439978 | 0.357 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.439978 | 0.357 |
| R-HSA-381042 | PERK regulates gene expression | 0.439978 | 0.357 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.439978 | 0.357 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.440424 | 0.356 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.441693 | 0.355 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.447666 | 0.349 |
| R-HSA-3371511 | HSF1 activation | 0.447666 | 0.349 |
| R-HSA-111933 | Calmodulin induced events | 0.447666 | 0.349 |
| R-HSA-111997 | CaM pathway | 0.447666 | 0.349 |
| R-HSA-109581 | Apoptosis | 0.452135 | 0.345 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.462727 | 0.335 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.462727 | 0.335 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.462727 | 0.335 |
| R-HSA-69541 | Stabilization of p53 | 0.470104 | 0.328 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.470104 | 0.328 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.470104 | 0.328 |
| R-HSA-71336 | Pentose phosphate pathway | 0.470104 | 0.328 |
| R-HSA-111885 | Opioid Signalling | 0.471027 | 0.327 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.477380 | 0.321 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.477380 | 0.321 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.477380 | 0.321 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.477380 | 0.321 |
| R-HSA-9646399 | Aggrephagy | 0.477380 | 0.321 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.479974 | 0.319 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.484412 | 0.315 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.484557 | 0.315 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.484557 | 0.315 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.484557 | 0.315 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.484557 | 0.315 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.484557 | 0.315 |
| R-HSA-69239 | Synthesis of DNA | 0.488828 | 0.311 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.491635 | 0.308 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.493219 | 0.307 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.493219 | 0.307 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.493219 | 0.307 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.498617 | 0.302 |
| R-HSA-111996 | Ca-dependent events | 0.498617 | 0.302 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.500997 | 0.300 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.501124 | 0.300 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.501931 | 0.299 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.501931 | 0.299 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.504404 | 0.297 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.505503 | 0.296 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.505503 | 0.296 |
| R-HSA-1280218 | Adaptive Immune System | 0.506908 | 0.295 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.510546 | 0.292 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.510546 | 0.292 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.512295 | 0.290 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.512295 | 0.290 |
| R-HSA-69236 | G1 Phase | 0.512295 | 0.290 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.512295 | 0.290 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.518994 | 0.285 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.518994 | 0.285 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.525602 | 0.279 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.525602 | 0.279 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.525602 | 0.279 |
| R-HSA-9675135 | Diseases of DNA repair | 0.525602 | 0.279 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.525602 | 0.279 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.527482 | 0.278 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.532119 | 0.274 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.532119 | 0.274 |
| R-HSA-69275 | G2/M Transition | 0.538016 | 0.269 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.538547 | 0.269 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.544557 | 0.264 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.544887 | 0.264 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.544887 | 0.264 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.544887 | 0.264 |
| R-HSA-73893 | DNA Damage Bypass | 0.544887 | 0.264 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.544887 | 0.264 |
| R-HSA-983712 | Ion channel transport | 0.547807 | 0.261 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.556157 | 0.255 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.557309 | 0.254 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.557309 | 0.254 |
| R-HSA-912446 | Meiotic recombination | 0.557309 | 0.254 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.557309 | 0.254 |
| R-HSA-2514856 | The phototransduction cascade | 0.557309 | 0.254 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.563392 | 0.249 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.563392 | 0.249 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.563392 | 0.249 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.563392 | 0.249 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.563392 | 0.249 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.564121 | 0.249 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.569392 | 0.245 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.569392 | 0.245 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.569392 | 0.245 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.575311 | 0.240 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.575311 | 0.240 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.578717 | 0.238 |
| R-HSA-418597 | G alpha (z) signalling events | 0.581148 | 0.236 |
| R-HSA-114608 | Platelet degranulation | 0.583582 | 0.234 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.586905 | 0.231 |
| R-HSA-5578775 | Ion homeostasis | 0.586905 | 0.231 |
| R-HSA-177929 | Signaling by EGFR | 0.586905 | 0.231 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.591854 | 0.228 |
| R-HSA-162582 | Signal Transduction | 0.597196 | 0.224 |
| R-HSA-9658195 | Leishmania infection | 0.597248 | 0.224 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.597248 | 0.224 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.598185 | 0.223 |
| R-HSA-1474165 | Reproduction | 0.598686 | 0.223 |
| R-HSA-5357801 | Programmed Cell Death | 0.600927 | 0.221 |
| R-HSA-9843745 | Adipogenesis | 0.602398 | 0.220 |
| R-HSA-379724 | tRNA Aminoacylation | 0.609157 | 0.215 |
| R-HSA-983189 | Kinesins | 0.609157 | 0.215 |
| R-HSA-450294 | MAP kinase activation | 0.614531 | 0.211 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.614531 | 0.211 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.619832 | 0.208 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.619832 | 0.208 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.619832 | 0.208 |
| R-HSA-9707616 | Heme signaling | 0.619832 | 0.208 |
| R-HSA-9824446 | Viral Infection Pathways | 0.622640 | 0.206 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.624125 | 0.205 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.625060 | 0.204 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.625060 | 0.204 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.625060 | 0.204 |
| R-HSA-8848021 | Signaling by PTK6 | 0.625060 | 0.204 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.625060 | 0.204 |
| R-HSA-6807070 | PTEN Regulation | 0.634641 | 0.197 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.635302 | 0.197 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.635302 | 0.197 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.640318 | 0.194 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.640318 | 0.194 |
| R-HSA-5218859 | Regulated Necrosis | 0.650145 | 0.187 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.659704 | 0.181 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.659704 | 0.181 |
| R-HSA-448424 | Interleukin-17 signaling | 0.659704 | 0.181 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.659704 | 0.181 |
| R-HSA-422475 | Axon guidance | 0.666119 | 0.176 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.668038 | 0.175 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.669004 | 0.175 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.669004 | 0.175 |
| R-HSA-9758941 | Gastrulation | 0.671239 | 0.173 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.673558 | 0.172 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.678051 | 0.169 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.678051 | 0.169 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.680694 | 0.167 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.680694 | 0.167 |
| R-HSA-380287 | Centrosome maturation | 0.682481 | 0.166 |
| R-HSA-8852135 | Protein ubiquitination | 0.682481 | 0.166 |
| R-HSA-69306 | DNA Replication | 0.683795 | 0.165 |
| R-HSA-5689603 | UCH proteinases | 0.686851 | 0.163 |
| R-HSA-8939211 | ESR-mediated signaling | 0.689298 | 0.162 |
| R-HSA-5619084 | ABC transporter disorders | 0.695412 | 0.158 |
| R-HSA-216083 | Integrin cell surface interactions | 0.695412 | 0.158 |
| R-HSA-9711097 | Cellular response to starvation | 0.698938 | 0.156 |
| R-HSA-877300 | Interferon gamma signaling | 0.701893 | 0.154 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.703740 | 0.153 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.703740 | 0.153 |
| R-HSA-9833482 | PKR-mediated signaling | 0.703740 | 0.153 |
| R-HSA-199991 | Membrane Trafficking | 0.706820 | 0.151 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.711841 | 0.148 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.716313 | 0.145 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.719722 | 0.143 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.723581 | 0.141 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.727388 | 0.138 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.727388 | 0.138 |
| R-HSA-9675108 | Nervous system development | 0.728321 | 0.138 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.731142 | 0.136 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.734845 | 0.134 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.734845 | 0.134 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.738497 | 0.132 |
| R-HSA-156902 | Peptide chain elongation | 0.738497 | 0.132 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.738497 | 0.132 |
| R-HSA-9663891 | Selective autophagy | 0.738497 | 0.132 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.743404 | 0.129 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.743404 | 0.129 |
| R-HSA-5663205 | Infectious disease | 0.745264 | 0.128 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.745652 | 0.127 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.745652 | 0.127 |
| R-HSA-416476 | G alpha (q) signalling events | 0.751821 | 0.124 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.752612 | 0.123 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.756020 | 0.121 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.756020 | 0.121 |
| R-HSA-391251 | Protein folding | 0.756020 | 0.121 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.759382 | 0.120 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.759382 | 0.120 |
| R-HSA-212436 | Generic Transcription Pathway | 0.759742 | 0.119 |
| R-HSA-2559583 | Cellular Senescence | 0.761030 | 0.119 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.762698 | 0.118 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.765968 | 0.116 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.765968 | 0.116 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.769193 | 0.114 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.769193 | 0.114 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.772374 | 0.112 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.772374 | 0.112 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.773993 | 0.111 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.775511 | 0.110 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.775511 | 0.110 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.778606 | 0.109 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.778606 | 0.109 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.778606 | 0.109 |
| R-HSA-190236 | Signaling by FGFR | 0.778606 | 0.109 |
| R-HSA-3214847 | HATs acetylate histones | 0.781658 | 0.107 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.784668 | 0.105 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.786616 | 0.104 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.787393 | 0.104 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.787636 | 0.104 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.787636 | 0.104 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.790564 | 0.102 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.790564 | 0.102 |
| R-HSA-1483255 | PI Metabolism | 0.790564 | 0.102 |
| R-HSA-192823 | Viral mRNA Translation | 0.793452 | 0.100 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.793452 | 0.100 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.796300 | 0.099 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.799109 | 0.097 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.799109 | 0.097 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.805733 | 0.094 |
| R-HSA-112316 | Neuronal System | 0.806375 | 0.093 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.807307 | 0.093 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.809965 | 0.092 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.812586 | 0.090 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.812586 | 0.090 |
| R-HSA-202403 | TCR signaling | 0.815171 | 0.089 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.822716 | 0.085 |
| R-HSA-1266738 | Developmental Biology | 0.828222 | 0.082 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.829955 | 0.081 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.830668 | 0.081 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.830788 | 0.081 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.832302 | 0.080 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.832302 | 0.080 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.836899 | 0.077 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.841371 | 0.075 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.841371 | 0.075 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.841371 | 0.075 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.845720 | 0.073 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.847851 | 0.072 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.847851 | 0.072 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.849951 | 0.071 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.849951 | 0.071 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.849951 | 0.071 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.853446 | 0.069 |
| R-HSA-69206 | G1/S Transition | 0.856082 | 0.067 |
| R-HSA-194138 | Signaling by VEGF | 0.856082 | 0.067 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.858070 | 0.066 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.861964 | 0.065 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.865751 | 0.063 |
| R-HSA-9717189 | Sensory perception of taste | 0.869435 | 0.061 |
| R-HSA-5576891 | Cardiac conduction | 0.869435 | 0.061 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.871239 | 0.060 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.871239 | 0.060 |
| R-HSA-9909396 | Circadian clock | 0.871239 | 0.060 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.881554 | 0.055 |
| R-HSA-5368287 | Mitochondrial translation | 0.883192 | 0.054 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.883192 | 0.054 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.884806 | 0.053 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.888758 | 0.051 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.898375 | 0.047 |
| R-HSA-2187338 | Visual phototransduction | 0.898375 | 0.047 |
| R-HSA-166520 | Signaling by NTRKs | 0.899781 | 0.046 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.899824 | 0.046 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.902949 | 0.044 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.907818 | 0.042 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.912816 | 0.040 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.915213 | 0.038 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.923972 | 0.034 |
| R-HSA-168256 | Immune System | 0.925274 | 0.034 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.929272 | 0.032 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.932172 | 0.031 |
| R-HSA-1483257 | Phospholipid metabolism | 0.932383 | 0.030 |
| R-HSA-5617833 | Cilium Assembly | 0.944987 | 0.025 |
| R-HSA-449147 | Signaling by Interleukins | 0.945276 | 0.024 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.952161 | 0.021 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.953479 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.954125 | 0.020 |
| R-HSA-1643685 | Disease | 0.961997 | 0.017 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.963013 | 0.016 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.968557 | 0.014 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.972667 | 0.012 |
| R-HSA-157118 | Signaling by NOTCH | 0.973047 | 0.012 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.978463 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 0.982149 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.985120 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.986241 | 0.006 |
| R-HSA-109582 | Hemostasis | 0.987522 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 0.990309 | 0.004 |
| R-HSA-1474244 | Extracellular matrix organization | 0.992497 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 0.993988 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.994830 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997088 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.998609 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998731 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999514 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999981 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.875 | 0.170 | 2 | 0.881 |
CLK3 |
0.873 | 0.230 | 1 | 0.831 |
BMPR1B |
0.872 | 0.460 | 1 | 0.774 |
DSTYK |
0.869 | 0.214 | 2 | 0.893 |
TGFBR1 |
0.866 | 0.481 | -2 | 0.948 |
CDC7 |
0.865 | 0.089 | 1 | 0.835 |
MOS |
0.865 | 0.124 | 1 | 0.848 |
ALK2 |
0.864 | 0.512 | -2 | 0.938 |
BMPR1A |
0.862 | 0.480 | 1 | 0.764 |
PRPK |
0.860 | -0.075 | -1 | 0.828 |
TGFBR2 |
0.860 | 0.291 | -2 | 0.921 |
ALK4 |
0.859 | 0.442 | -2 | 0.945 |
BMPR2 |
0.859 | 0.172 | -2 | 0.873 |
PIM3 |
0.859 | 0.038 | -3 | 0.788 |
CAMK2G |
0.858 | 0.031 | 2 | 0.824 |
GCN2 |
0.858 | 0.013 | 2 | 0.818 |
FAM20C |
0.857 | 0.190 | 2 | 0.662 |
GRK6 |
0.856 | 0.136 | 1 | 0.793 |
CAMK1B |
0.856 | -0.011 | -3 | 0.826 |
ACVR2A |
0.856 | 0.358 | -2 | 0.915 |
NEK6 |
0.855 | 0.100 | -2 | 0.865 |
IKKB |
0.855 | -0.039 | -2 | 0.705 |
ATR |
0.855 | 0.034 | 1 | 0.824 |
ACVR2B |
0.854 | 0.350 | -2 | 0.920 |
ATM |
0.854 | 0.137 | 1 | 0.781 |
GRK7 |
0.853 | 0.215 | 1 | 0.726 |
RAF1 |
0.853 | -0.095 | 1 | 0.797 |
NEK7 |
0.853 | 0.029 | -3 | 0.814 |
NLK |
0.852 | -0.002 | 1 | 0.806 |
GRK1 |
0.852 | 0.103 | -2 | 0.732 |
ULK2 |
0.852 | -0.073 | 2 | 0.803 |
MTOR |
0.852 | -0.109 | 1 | 0.754 |
ERK5 |
0.851 | 0.054 | 1 | 0.828 |
TBK1 |
0.851 | -0.059 | 1 | 0.691 |
RSK2 |
0.850 | 0.039 | -3 | 0.732 |
CDKL1 |
0.850 | -0.007 | -3 | 0.761 |
PLK1 |
0.850 | 0.164 | -2 | 0.857 |
PDHK4 |
0.850 | -0.252 | 1 | 0.809 |
CAMK2B |
0.850 | 0.121 | 2 | 0.798 |
PIM1 |
0.849 | 0.052 | -3 | 0.739 |
IKKA |
0.849 | 0.050 | -2 | 0.711 |
SRPK1 |
0.849 | 0.053 | -3 | 0.716 |
NDR2 |
0.849 | -0.020 | -3 | 0.789 |
IKKE |
0.848 | -0.067 | 1 | 0.694 |
GRK5 |
0.848 | -0.052 | -3 | 0.813 |
NUAK2 |
0.847 | -0.009 | -3 | 0.799 |
PLK3 |
0.847 | 0.156 | 2 | 0.776 |
NIK |
0.847 | -0.077 | -3 | 0.841 |
KIS |
0.847 | 0.095 | 1 | 0.708 |
HUNK |
0.847 | -0.054 | 2 | 0.826 |
PRKD1 |
0.847 | 0.008 | -3 | 0.768 |
PKN3 |
0.846 | -0.041 | -3 | 0.782 |
MAPKAPK2 |
0.845 | 0.059 | -3 | 0.681 |
MLK1 |
0.845 | -0.059 | 2 | 0.838 |
MARK4 |
0.845 | -0.012 | 4 | 0.875 |
PDHK1 |
0.845 | -0.188 | 1 | 0.808 |
ULK1 |
0.845 | -0.078 | -3 | 0.801 |
GRK4 |
0.845 | 0.021 | -2 | 0.812 |
TSSK2 |
0.844 | 0.020 | -5 | 0.870 |
CDKL5 |
0.844 | 0.016 | -3 | 0.747 |
CAMLCK |
0.844 | -0.067 | -2 | 0.762 |
LATS1 |
0.844 | 0.099 | -3 | 0.804 |
SRPK2 |
0.843 | 0.063 | -3 | 0.642 |
MST4 |
0.843 | -0.024 | 2 | 0.865 |
PRKD2 |
0.842 | 0.012 | -3 | 0.727 |
P90RSK |
0.842 | -0.012 | -3 | 0.740 |
LATS2 |
0.842 | 0.011 | -5 | 0.767 |
CAMK2D |
0.842 | -0.027 | -3 | 0.783 |
CLK4 |
0.842 | 0.085 | -3 | 0.740 |
AMPKA1 |
0.842 | -0.020 | -3 | 0.804 |
CK2A2 |
0.842 | 0.265 | 1 | 0.683 |
CLK1 |
0.842 | 0.112 | -3 | 0.720 |
DAPK2 |
0.842 | -0.084 | -3 | 0.824 |
CAMK2A |
0.842 | 0.068 | 2 | 0.804 |
CLK2 |
0.841 | 0.142 | -3 | 0.722 |
TLK2 |
0.841 | 0.167 | 1 | 0.779 |
SRPK3 |
0.841 | 0.043 | -3 | 0.693 |
CHAK2 |
0.841 | -0.074 | -1 | 0.804 |
DLK |
0.840 | -0.117 | 1 | 0.784 |
CDK1 |
0.840 | 0.097 | 1 | 0.643 |
SKMLCK |
0.840 | -0.071 | -2 | 0.756 |
NEK9 |
0.840 | -0.106 | 2 | 0.848 |
RSK3 |
0.839 | -0.020 | -3 | 0.734 |
HIPK4 |
0.839 | -0.020 | 1 | 0.791 |
TSSK1 |
0.839 | 0.014 | -3 | 0.821 |
TLK1 |
0.839 | 0.194 | -2 | 0.899 |
MAPKAPK3 |
0.839 | -0.034 | -3 | 0.725 |
WNK1 |
0.838 | -0.117 | -2 | 0.751 |
P70S6KB |
0.838 | -0.028 | -3 | 0.758 |
NDR1 |
0.838 | -0.076 | -3 | 0.786 |
PKCD |
0.838 | -0.022 | 2 | 0.808 |
PKR |
0.838 | 0.000 | 1 | 0.791 |
JNK3 |
0.837 | 0.090 | 1 | 0.668 |
JNK2 |
0.837 | 0.101 | 1 | 0.632 |
ICK |
0.837 | -0.041 | -3 | 0.789 |
CDK8 |
0.837 | 0.024 | 1 | 0.689 |
PKN2 |
0.836 | -0.084 | -3 | 0.791 |
ANKRD3 |
0.836 | -0.101 | 1 | 0.797 |
AMPKA2 |
0.836 | -0.023 | -3 | 0.772 |
TTBK2 |
0.835 | -0.106 | 2 | 0.712 |
DNAPK |
0.835 | 0.082 | 1 | 0.718 |
BCKDK |
0.835 | -0.152 | -1 | 0.752 |
CDK5 |
0.833 | 0.069 | 1 | 0.701 |
YSK4 |
0.833 | -0.062 | 1 | 0.729 |
RIPK3 |
0.833 | -0.215 | 3 | 0.621 |
MEK1 |
0.833 | -0.118 | 2 | 0.857 |
SMG1 |
0.833 | 0.021 | 1 | 0.787 |
RSK4 |
0.833 | 0.026 | -3 | 0.701 |
DYRK2 |
0.833 | 0.028 | 1 | 0.727 |
CDK2 |
0.832 | 0.061 | 1 | 0.707 |
MLK3 |
0.831 | -0.045 | 2 | 0.768 |
PERK |
0.831 | 0.079 | -2 | 0.879 |
CHK1 |
0.831 | 0.002 | -3 | 0.775 |
WNK3 |
0.831 | -0.276 | 1 | 0.767 |
GRK2 |
0.830 | -0.010 | -2 | 0.721 |
MLK4 |
0.830 | -0.014 | 2 | 0.751 |
PKACG |
0.830 | -0.071 | -2 | 0.651 |
P38A |
0.830 | 0.042 | 1 | 0.720 |
NUAK1 |
0.830 | -0.046 | -3 | 0.756 |
BRAF |
0.830 | 0.009 | -4 | 0.832 |
NIM1 |
0.829 | -0.120 | 3 | 0.700 |
QSK |
0.829 | -0.023 | 4 | 0.852 |
CK2A1 |
0.829 | 0.211 | 1 | 0.656 |
PRKD3 |
0.829 | -0.031 | -3 | 0.717 |
CDK3 |
0.829 | 0.117 | 1 | 0.590 |
P38G |
0.829 | 0.075 | 1 | 0.569 |
MLK2 |
0.829 | -0.196 | 2 | 0.832 |
HRI |
0.829 | 0.010 | -2 | 0.878 |
MSK2 |
0.829 | -0.069 | -3 | 0.697 |
PRP4 |
0.829 | 0.047 | -3 | 0.745 |
MASTL |
0.829 | -0.360 | -2 | 0.751 |
AURC |
0.828 | -0.027 | -2 | 0.562 |
P38B |
0.828 | 0.061 | 1 | 0.671 |
PLK2 |
0.828 | 0.159 | -3 | 0.830 |
CDK19 |
0.828 | 0.010 | 1 | 0.654 |
CAMK4 |
0.828 | -0.141 | -3 | 0.773 |
VRK2 |
0.827 | -0.249 | 1 | 0.837 |
PAK1 |
0.826 | -0.085 | -2 | 0.666 |
MARK2 |
0.826 | -0.010 | 4 | 0.779 |
MARK3 |
0.826 | -0.007 | 4 | 0.813 |
MSK1 |
0.826 | -0.030 | -3 | 0.701 |
NEK2 |
0.826 | -0.118 | 2 | 0.820 |
IRE1 |
0.826 | -0.150 | 1 | 0.741 |
SIK |
0.826 | -0.037 | -3 | 0.728 |
AURA |
0.825 | -0.030 | -2 | 0.544 |
PKACB |
0.825 | -0.008 | -2 | 0.587 |
BRSK1 |
0.825 | -0.042 | -3 | 0.754 |
MELK |
0.825 | -0.086 | -3 | 0.759 |
IRE2 |
0.825 | -0.074 | 2 | 0.782 |
PKCB |
0.823 | -0.057 | 2 | 0.759 |
MYLK4 |
0.823 | -0.074 | -2 | 0.677 |
PIM2 |
0.823 | -0.009 | -3 | 0.709 |
QIK |
0.823 | -0.143 | -3 | 0.784 |
PRKX |
0.823 | 0.029 | -3 | 0.641 |
ERK1 |
0.823 | 0.031 | 1 | 0.651 |
MARK1 |
0.823 | -0.035 | 4 | 0.834 |
AURB |
0.822 | -0.051 | -2 | 0.562 |
CDK13 |
0.822 | -0.010 | 1 | 0.659 |
GRK3 |
0.822 | 0.020 | -2 | 0.691 |
RIPK1 |
0.822 | -0.325 | 1 | 0.742 |
MEKK3 |
0.822 | -0.129 | 1 | 0.749 |
EEF2K |
0.822 | 0.110 | 3 | 0.794 |
MNK2 |
0.822 | -0.087 | -2 | 0.688 |
PAK3 |
0.821 | -0.138 | -2 | 0.670 |
DCAMKL1 |
0.821 | -0.012 | -3 | 0.751 |
PINK1 |
0.821 | -0.123 | 1 | 0.779 |
MEKK2 |
0.821 | -0.074 | 2 | 0.824 |
ERK2 |
0.821 | 0.007 | 1 | 0.679 |
HIPK1 |
0.820 | 0.020 | 1 | 0.731 |
PKCA |
0.820 | -0.074 | 2 | 0.753 |
PKCG |
0.820 | -0.093 | 2 | 0.759 |
PAK6 |
0.820 | -0.032 | -2 | 0.588 |
P38D |
0.820 | 0.072 | 1 | 0.602 |
CHAK1 |
0.820 | -0.180 | 2 | 0.763 |
AKT2 |
0.820 | -0.028 | -3 | 0.659 |
NEK5 |
0.820 | -0.083 | 1 | 0.776 |
CDK7 |
0.819 | -0.034 | 1 | 0.687 |
PKCH |
0.819 | -0.097 | 2 | 0.751 |
PASK |
0.819 | -0.027 | -3 | 0.796 |
HIPK2 |
0.819 | 0.036 | 1 | 0.639 |
DYRK4 |
0.819 | 0.045 | 1 | 0.656 |
PKG2 |
0.818 | -0.050 | -2 | 0.582 |
SGK3 |
0.818 | -0.047 | -3 | 0.711 |
MNK1 |
0.818 | -0.079 | -2 | 0.705 |
MEKK1 |
0.818 | -0.153 | 1 | 0.768 |
ZAK |
0.818 | -0.124 | 1 | 0.743 |
GSK3A |
0.818 | 0.046 | 4 | 0.467 |
CDK18 |
0.818 | 0.013 | 1 | 0.618 |
JNK1 |
0.817 | 0.066 | 1 | 0.619 |
CAMK1G |
0.817 | -0.089 | -3 | 0.725 |
PLK4 |
0.817 | -0.109 | 2 | 0.660 |
PAK2 |
0.816 | -0.140 | -2 | 0.653 |
DYRK1A |
0.816 | -0.008 | 1 | 0.737 |
PHKG1 |
0.816 | -0.101 | -3 | 0.776 |
DCAMKL2 |
0.816 | -0.035 | -3 | 0.778 |
DRAK1 |
0.816 | -0.146 | 1 | 0.664 |
MEK5 |
0.816 | -0.288 | 2 | 0.838 |
BRSK2 |
0.815 | -0.115 | -3 | 0.769 |
CDK12 |
0.815 | -0.009 | 1 | 0.634 |
SSTK |
0.815 | -0.026 | 4 | 0.840 |
GAK |
0.815 | -0.032 | 1 | 0.773 |
CDK17 |
0.815 | 0.014 | 1 | 0.569 |
TAO3 |
0.815 | -0.080 | 1 | 0.744 |
MAPKAPK5 |
0.814 | -0.137 | -3 | 0.669 |
CDK9 |
0.814 | -0.027 | 1 | 0.665 |
GSK3B |
0.814 | -0.004 | 4 | 0.455 |
CK1E |
0.814 | -0.059 | -3 | 0.521 |
CAMKK1 |
0.814 | -0.140 | -2 | 0.693 |
CAMK1D |
0.814 | -0.023 | -3 | 0.653 |
DYRK1B |
0.814 | 0.019 | 1 | 0.662 |
SMMLCK |
0.813 | -0.102 | -3 | 0.774 |
PKCZ |
0.812 | -0.155 | 2 | 0.792 |
MST2 |
0.812 | -0.017 | 1 | 0.765 |
MST3 |
0.812 | -0.102 | 2 | 0.845 |
NEK8 |
0.811 | -0.125 | 2 | 0.831 |
DYRK3 |
0.811 | -0.007 | 1 | 0.737 |
PKACA |
0.811 | -0.024 | -2 | 0.540 |
SNRK |
0.810 | -0.234 | 2 | 0.702 |
WNK4 |
0.810 | -0.207 | -2 | 0.743 |
CDK16 |
0.809 | 0.035 | 1 | 0.586 |
TAK1 |
0.809 | -0.042 | 1 | 0.780 |
HIPK3 |
0.809 | -0.033 | 1 | 0.720 |
DAPK3 |
0.808 | -0.045 | -3 | 0.762 |
ERK7 |
0.808 | 0.011 | 2 | 0.559 |
TAO2 |
0.807 | -0.127 | 2 | 0.856 |
CDK14 |
0.807 | -0.008 | 1 | 0.648 |
CK1D |
0.807 | -0.055 | -3 | 0.466 |
TNIK |
0.807 | -0.032 | 3 | 0.797 |
AKT1 |
0.806 | -0.045 | -3 | 0.668 |
IRAK4 |
0.806 | -0.201 | 1 | 0.750 |
GCK |
0.806 | -0.085 | 1 | 0.740 |
P70S6K |
0.806 | -0.079 | -3 | 0.668 |
CAMKK2 |
0.805 | -0.178 | -2 | 0.682 |
TTBK1 |
0.805 | -0.160 | 2 | 0.628 |
CK1G1 |
0.805 | -0.072 | -3 | 0.536 |
MST1 |
0.804 | -0.049 | 1 | 0.745 |
DAPK1 |
0.803 | -0.057 | -3 | 0.743 |
MINK |
0.803 | -0.099 | 1 | 0.745 |
CK1A2 |
0.803 | -0.068 | -3 | 0.468 |
LKB1 |
0.803 | -0.187 | -3 | 0.789 |
TTK |
0.802 | 0.147 | -2 | 0.877 |
CDK10 |
0.802 | 0.008 | 1 | 0.632 |
PKCT |
0.802 | -0.126 | 2 | 0.757 |
PHKG2 |
0.802 | -0.117 | -3 | 0.764 |
HGK |
0.802 | -0.103 | 3 | 0.779 |
NEK11 |
0.801 | -0.278 | 1 | 0.724 |
SGK1 |
0.801 | -0.011 | -3 | 0.574 |
NEK4 |
0.800 | -0.196 | 1 | 0.741 |
VRK1 |
0.799 | -0.181 | 2 | 0.856 |
MRCKA |
0.799 | -0.028 | -3 | 0.713 |
CDK6 |
0.799 | 0.013 | 1 | 0.630 |
MPSK1 |
0.799 | -0.166 | 1 | 0.723 |
LRRK2 |
0.799 | -0.220 | 2 | 0.852 |
CHK2 |
0.799 | -0.044 | -3 | 0.607 |
PDK1 |
0.798 | -0.203 | 1 | 0.724 |
IRAK1 |
0.798 | -0.301 | -1 | 0.702 |
MRCKB |
0.798 | -0.036 | -3 | 0.701 |
PKCE |
0.797 | -0.068 | 2 | 0.747 |
CDK4 |
0.797 | 0.003 | 1 | 0.626 |
CAMK1A |
0.797 | -0.048 | -3 | 0.628 |
SBK |
0.796 | -0.012 | -3 | 0.543 |
ROCK2 |
0.796 | -0.033 | -3 | 0.740 |
NEK1 |
0.796 | -0.170 | 1 | 0.743 |
PKCI |
0.796 | -0.138 | 2 | 0.767 |
LOK |
0.796 | -0.133 | -2 | 0.693 |
MAK |
0.795 | 0.013 | -2 | 0.600 |
OSR1 |
0.795 | -0.003 | 2 | 0.815 |
HPK1 |
0.795 | -0.134 | 1 | 0.724 |
ALPHAK3 |
0.794 | 0.030 | -1 | 0.782 |
MEKK6 |
0.794 | -0.233 | 1 | 0.772 |
PAK5 |
0.794 | -0.107 | -2 | 0.532 |
KHS2 |
0.793 | -0.053 | 1 | 0.741 |
MAP3K15 |
0.793 | -0.233 | 1 | 0.724 |
MEK2 |
0.793 | -0.223 | 2 | 0.827 |
AKT3 |
0.793 | -0.038 | -3 | 0.590 |
KHS1 |
0.793 | -0.091 | 1 | 0.738 |
MOK |
0.792 | -0.005 | 1 | 0.755 |
SLK |
0.791 | -0.135 | -2 | 0.651 |
DMPK1 |
0.791 | -0.017 | -3 | 0.724 |
PAK4 |
0.790 | -0.098 | -2 | 0.541 |
PKN1 |
0.790 | -0.107 | -3 | 0.683 |
BUB1 |
0.790 | -0.051 | -5 | 0.834 |
YSK1 |
0.789 | -0.155 | 2 | 0.820 |
STK33 |
0.788 | -0.207 | 2 | 0.624 |
PDHK3_TYR |
0.787 | 0.150 | 4 | 0.921 |
PBK |
0.785 | -0.126 | 1 | 0.711 |
BIKE |
0.785 | -0.036 | 1 | 0.651 |
RIPK2 |
0.783 | -0.311 | 1 | 0.687 |
ROCK1 |
0.783 | -0.053 | -3 | 0.712 |
NEK3 |
0.782 | -0.205 | 1 | 0.722 |
CRIK |
0.781 | -0.033 | -3 | 0.656 |
MAP2K6_TYR |
0.780 | 0.085 | -1 | 0.849 |
MAP2K4_TYR |
0.779 | 0.021 | -1 | 0.854 |
PDHK4_TYR |
0.779 | 0.052 | 2 | 0.875 |
MYO3B |
0.778 | -0.132 | 2 | 0.831 |
PDHK1_TYR |
0.777 | 0.065 | -1 | 0.872 |
BMPR2_TYR |
0.777 | 0.025 | -1 | 0.841 |
HASPIN |
0.777 | -0.083 | -1 | 0.652 |
PKG1 |
0.776 | -0.092 | -2 | 0.506 |
MYO3A |
0.776 | -0.130 | 1 | 0.728 |
ASK1 |
0.775 | -0.225 | 1 | 0.712 |
EPHA6 |
0.774 | 0.088 | -1 | 0.865 |
TESK1_TYR |
0.774 | -0.130 | 3 | 0.819 |
STLK3 |
0.774 | -0.135 | 1 | 0.710 |
YANK3 |
0.773 | -0.100 | 2 | 0.400 |
MAP2K7_TYR |
0.772 | -0.199 | 2 | 0.864 |
TXK |
0.771 | 0.166 | 1 | 0.800 |
TAO1 |
0.771 | -0.172 | 1 | 0.680 |
AAK1 |
0.770 | 0.003 | 1 | 0.555 |
EPHB4 |
0.770 | 0.060 | -1 | 0.848 |
PINK1_TYR |
0.769 | -0.180 | 1 | 0.785 |
PKMYT1_TYR |
0.768 | -0.189 | 3 | 0.762 |
FER |
0.766 | 0.029 | 1 | 0.853 |
EPHA4 |
0.764 | 0.048 | 2 | 0.774 |
CK1A |
0.764 | -0.092 | -3 | 0.386 |
RET |
0.764 | -0.115 | 1 | 0.771 |
ABL2 |
0.763 | 0.043 | -1 | 0.825 |
YES1 |
0.763 | 0.025 | -1 | 0.823 |
LIMK2_TYR |
0.762 | -0.161 | -3 | 0.836 |
EPHB2 |
0.761 | 0.082 | -1 | 0.832 |
FGR |
0.761 | -0.022 | 1 | 0.802 |
SRMS |
0.761 | 0.041 | 1 | 0.829 |
BLK |
0.760 | 0.115 | -1 | 0.828 |
TYRO3 |
0.759 | -0.110 | 3 | 0.668 |
EPHB1 |
0.759 | 0.019 | 1 | 0.834 |
INSRR |
0.759 | -0.020 | 3 | 0.617 |
TYK2 |
0.759 | -0.180 | 1 | 0.773 |
EPHB3 |
0.759 | 0.033 | -1 | 0.836 |
ABL1 |
0.759 | 0.011 | -1 | 0.816 |
ROS1 |
0.758 | -0.113 | 3 | 0.633 |
HCK |
0.757 | -0.007 | -1 | 0.811 |
ITK |
0.757 | 0.009 | -1 | 0.781 |
TEC |
0.757 | 0.074 | -1 | 0.764 |
LIMK1_TYR |
0.757 | -0.290 | 2 | 0.860 |
MST1R |
0.757 | -0.202 | 3 | 0.672 |
DDR1 |
0.756 | -0.181 | 4 | 0.840 |
LCK |
0.756 | 0.037 | -1 | 0.809 |
CK1G3 |
0.756 | -0.064 | -3 | 0.343 |
CSF1R |
0.756 | -0.111 | 3 | 0.640 |
JAK2 |
0.756 | -0.167 | 1 | 0.776 |
FGFR2 |
0.754 | -0.078 | 3 | 0.673 |
BMX |
0.754 | 0.017 | -1 | 0.737 |
JAK3 |
0.754 | -0.118 | 1 | 0.750 |
FYN |
0.752 | 0.058 | -1 | 0.781 |
EPHA7 |
0.751 | 0.002 | 2 | 0.777 |
MERTK |
0.750 | -0.040 | 3 | 0.627 |
KIT |
0.750 | -0.103 | 3 | 0.650 |
FLT3 |
0.750 | -0.119 | 3 | 0.647 |
TEK |
0.749 | -0.114 | 3 | 0.598 |
TNNI3K_TYR |
0.748 | -0.058 | 1 | 0.812 |
BTK |
0.748 | -0.088 | -1 | 0.755 |
PTK6 |
0.748 | -0.089 | -1 | 0.719 |
TNK2 |
0.748 | -0.120 | 3 | 0.598 |
PDGFRB |
0.748 | -0.164 | 3 | 0.663 |
EPHA5 |
0.748 | 0.031 | 2 | 0.764 |
FRK |
0.747 | 0.008 | -1 | 0.856 |
NEK10_TYR |
0.747 | -0.155 | 1 | 0.633 |
EGFR |
0.746 | 0.015 | 1 | 0.644 |
FLT1 |
0.746 | -0.058 | -1 | 0.836 |
EPHA3 |
0.745 | -0.089 | 2 | 0.750 |
KDR |
0.745 | -0.140 | 3 | 0.599 |
FGFR1 |
0.745 | -0.152 | 3 | 0.622 |
LTK |
0.745 | -0.092 | 3 | 0.593 |
AXL |
0.745 | -0.142 | 3 | 0.629 |
SYK |
0.744 | 0.063 | -1 | 0.781 |
ERBB2 |
0.744 | -0.111 | 1 | 0.728 |
LYN |
0.744 | -0.019 | 3 | 0.572 |
FGFR3 |
0.744 | -0.089 | 3 | 0.642 |
MET |
0.743 | -0.112 | 3 | 0.633 |
ALK |
0.743 | -0.130 | 3 | 0.566 |
NTRK1 |
0.743 | -0.148 | -1 | 0.806 |
CK1G2 |
0.742 | -0.040 | -3 | 0.444 |
EPHA8 |
0.742 | -0.009 | -1 | 0.821 |
PTK2B |
0.742 | -0.023 | -1 | 0.778 |
YANK2 |
0.741 | -0.124 | 2 | 0.422 |
WEE1_TYR |
0.741 | -0.156 | -1 | 0.725 |
MATK |
0.741 | -0.081 | -1 | 0.758 |
JAK1 |
0.741 | -0.160 | 1 | 0.712 |
PTK2 |
0.740 | 0.010 | -1 | 0.766 |
SRC |
0.740 | -0.020 | -1 | 0.792 |
INSR |
0.739 | -0.131 | 3 | 0.595 |
TNK1 |
0.739 | -0.218 | 3 | 0.646 |
EPHA1 |
0.739 | -0.110 | 3 | 0.593 |
PDGFRA |
0.738 | -0.264 | 3 | 0.659 |
FLT4 |
0.737 | -0.155 | 3 | 0.614 |
FGFR4 |
0.737 | -0.040 | -1 | 0.787 |
NTRK3 |
0.736 | -0.115 | -1 | 0.768 |
NTRK2 |
0.736 | -0.183 | 3 | 0.608 |
CSK |
0.735 | -0.111 | 2 | 0.780 |
DDR2 |
0.735 | -0.100 | 3 | 0.596 |
EPHA2 |
0.733 | -0.017 | -1 | 0.793 |
IGF1R |
0.729 | -0.084 | 3 | 0.543 |
ERBB4 |
0.728 | -0.033 | 1 | 0.668 |
MUSK |
0.723 | -0.140 | 1 | 0.624 |
FES |
0.712 | -0.135 | -1 | 0.711 |
ZAP70 |
0.709 | -0.067 | -1 | 0.690 |