Motif 656 (n=101)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | S30 | ochoa | Protein FAM234B | None |
| H3BU86 | STX16-NPEPL1 | S201 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| O00461 | GOLIM4 | S364 | ochoa | Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa) | Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}. |
| O14513 | NCKAP5 | S613 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14662 | STX16 | S201 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O60716 | CTNND1 | S125 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75379 | VAMP4 | S30 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75391 | SPAG7 | S114 | ochoa | Sperm-associated antigen 7 | None |
| O75475 | PSIP1 | S118 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75475 | PSIP1 | S129 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75533 | SF3B1 | S129 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75533 | SF3B1 | S400 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| P06753 | TPM3 | Y222 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07108 | DBI | S21 | psp | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| P07910 | HNRNPC | S260 | ochoa|psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P07951 | TPM2 | Y221 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P10451 | SPP1 | S291 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10636 | MAPT | S214 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10645 | CHGA | S333 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P16070 | CD44 | S717 | ochoa | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P16157 | ANK1 | S1617 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P21673 | SAT1 | S149 | psp | Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) | Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}. |
| P26358 | DNMT1 | S192 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P33176 | KIF5B | S175 | psp | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P35269 | GTF2F1 | S224 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35610 | SOAT1 | S33 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P38398 | BRCA1 | S451 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40818 | USP8 | S153 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P46087 | NOP2 | S36 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P48634 | PRRC2A | S365 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S746 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S421 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P50502 | ST13 | S75 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P50851 | LRBA | S1247 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P52179 | MYOM1 | S1177 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52655 | GTF2A1 | S321 | psp | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:16537915}. |
| P67936 | TPM4 | Y185 | ochoa | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}. |
| P98088 | MUC5AC | S1812 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| P98088 | MUC5AC | S3291 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| P98088 | MUC5AC | S4696 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| Q01105 | SET | S133 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01484 | ANK2 | S846 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02880 | TOP2B | S1375 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q03701 | CEBPZ | S41 | ochoa | CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) | Stimulates transcription from the HSP70 promoter. |
| Q06190 | PPP2R3A | S505 | ochoa | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q07869 | PPARA | S280 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q08495 | DMTN | S383 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12840 | KIF5A | S176 | ochoa | Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {ECO:0000250|UniProtKB:P33175, ECO:0000250|UniProtKB:Q6QLM7}. |
| Q14135 | VGLL4 | S59 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14161 | GIT2 | S397 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14677 | CLINT1 | S234 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14789 | GOLGB1 | S139 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S539 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15649 | ZNHIT3 | S80 | ochoa | Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3) | None |
| Q16539 | MAPK14 | S326 | ochoa | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
| Q5H9L2 | TCEAL5 | S36 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
| Q5SWA1 | PPP1R15B | S407 | ochoa | Protein phosphatase 1 regulatory subunit 15B | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269|PubMed:26159176, ECO:0000269|PubMed:26307080}. |
| Q5TH69 | ARFGEF3 | S628 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VTR2 | RNF20 | S42 | ochoa | E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| Q6PKG0 | LARP1 | S228 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZNE5 | ATG14 | S425 | ochoa | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) | Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604, PubMed:37632749). Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:37632749}. |
| Q7Z3T8 | ZFYVE16 | S193 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z7L9 | ZSCAN2 | S176 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q8IX90 | SKA3 | S334 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IZP2 | ST13P4 | S71 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8N4C6 | NIN | S1145 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8NFC6 | BOD1L1 | S2209 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFC6 | BOD1L1 | S2862 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TAQ2 | SMARCC2 | S387 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TEQ6 | GEMIN5 | S1322 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q92796 | DLG3 | S678 | ochoa | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| Q969E4 | TCEAL3 | S30 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q96S38 | RPS6KC1 | S608 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99426 | TBCB | S110 | ochoa | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| Q99547 | MPHOSPH6 | S110 | ochoa | M-phase phosphoprotein 6 | RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:26166824}. |
| Q99590 | SCAF11 | S449 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BSL1 | UBAC1 | S332 | ochoa | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612}. |
| Q9BXW9 | FANCD2 | S178 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BXY0 | MAK16 | S200 | ochoa | Protein MAK16 homolog (NNP78) (Protein RBM13) | None |
| Q9H4G0 | EPB41L1 | S466 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4L5 | OSBPL3 | S437 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H501 | ESF1 | S75 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9HCU9 | BRMS1 | S177 | ochoa | Breast cancer metastasis-suppressor 1 | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}. |
| Q9NQ66 | PLCB1 | S988 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9P1Y5 | CAMSAP3 | S877 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9UJX6 | ANAPC2 | S474 | ochoa | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UKS7 | IKZF2 | S79 | ochoa | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}. |
| Q9UKT5 | FBXO4 | S48 | ochoa | F-box only protein 4 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10531035, PubMed:18598945, PubMed:20181953, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:18598945). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (By similarity). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). {ECO:0000250|UniProtKB:Q8CHQ0, ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:29142209}. |
| Q9UKY1 | ZHX1 | S48 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UM63 | PLAGL1 | S341 | ochoa | Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC) | Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. {ECO:0000269|PubMed:18299245, ECO:0000269|PubMed:9722527}. |
| Q9UNY4 | TTF2 | S364 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9Y2L9 | LRCH1 | S393 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) | Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}. |
| Q9Y3E1 | HDGFL3 | S122 | ochoa | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}. |
| Q9Y485 | DMXL1 | S436 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y5B9 | SUPT16H | S982 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| O95835 | LATS1 | S876 | Sugiyama | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| O43252 | PAPSS1 | S231 | Sugiyama | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}. |
| P27797 | CALR | S189 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| O60282 | KIF5C | S176 | SIGNOR | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}. |
| P13073 | COX4I1 | S89 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P41252 | IARS1 | S827 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 7.127123e-08 | 7.147 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.203426e-07 | 6.376 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.185434e-04 | 3.497 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.457207e-04 | 3.461 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.457207e-04 | 3.461 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.977412e-04 | 3.400 |
| R-HSA-447038 | NrCAM interactions | 1.391093e-03 | 2.857 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 2.276557e-03 | 2.643 |
| R-HSA-983189 | Kinesins | 1.994527e-03 | 2.700 |
| R-HSA-199991 | Membrane Trafficking | 2.031391e-03 | 2.692 |
| R-HSA-264876 | Insulin processing | 2.218359e-03 | 2.654 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 2.796483e-03 | 2.553 |
| R-HSA-390522 | Striated Muscle Contraction | 3.799686e-03 | 2.420 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 3.366802e-03 | 2.473 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.349990e-03 | 2.362 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.830167e-03 | 2.316 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 6.136318e-03 | 2.212 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.644468e-03 | 2.178 |
| R-HSA-174362 | Transport and metabolism of PAPS | 9.650428e-03 | 2.015 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 9.089399e-03 | 2.041 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 9.541356e-03 | 2.020 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.733187e-03 | 2.012 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 7.803287e-03 | 2.108 |
| R-HSA-74160 | Gene expression (Transcription) | 9.068519e-03 | 2.042 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.199619e-02 | 1.921 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.528381e-02 | 1.816 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.528381e-02 | 1.816 |
| R-HSA-8953854 | Metabolism of RNA | 1.499526e-02 | 1.824 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.975870e-02 | 1.224 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 6.697495e-02 | 1.174 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 9.529468e-02 | 1.021 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.003960e-02 | 1.698 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.159734e-01 | 0.936 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.715393e-02 | 1.566 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.715393e-02 | 1.566 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.715393e-02 | 1.566 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.868224e-02 | 1.542 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.868224e-02 | 1.542 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.227616e-01 | 0.911 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.294980e-01 | 0.888 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.361832e-01 | 0.866 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.428174e-01 | 0.845 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.428174e-01 | 0.845 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.428174e-01 | 0.845 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.428174e-01 | 0.845 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.559346e-01 | 0.807 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.624183e-01 | 0.789 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.140769e-02 | 1.289 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.688526e-01 | 0.772 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.688526e-01 | 0.772 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.688526e-01 | 0.772 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.533048e-02 | 1.257 |
| R-HSA-167161 | HIV Transcription Initiation | 5.533048e-02 | 1.257 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.533048e-02 | 1.257 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.752379e-01 | 0.756 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.752379e-01 | 0.756 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.752379e-01 | 0.756 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.752379e-01 | 0.756 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.752379e-01 | 0.756 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 5.935509e-02 | 1.227 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.815745e-01 | 0.741 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.347755e-02 | 1.197 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.557426e-02 | 1.183 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.878629e-01 | 0.726 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.878629e-01 | 0.726 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.941033e-01 | 0.712 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.002961e-01 | 0.698 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.002961e-01 | 0.698 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 2.002961e-01 | 0.698 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 7.862160e-02 | 1.104 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 8.086976e-02 | 1.092 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.125405e-01 | 0.673 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.305593e-01 | 0.637 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.305593e-01 | 0.637 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.364742e-01 | 0.626 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.877189e-01 | 0.541 |
| R-HSA-167172 | Transcription of the HIV genome | 2.136242e-02 | 1.670 |
| R-HSA-72172 | mRNA Splicing | 2.488452e-01 | 0.604 |
| R-HSA-167169 | HIV Transcription Elongation | 5.140769e-02 | 1.289 |
| R-HSA-72086 | mRNA Capping | 2.364742e-01 | 0.626 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.264465e-01 | 0.645 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.140769e-02 | 1.289 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.665582e-01 | 0.778 |
| R-HSA-9762292 | Regulation of CDH11 function | 9.529468e-02 | 1.021 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.022403e-01 | 0.990 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.948575e-02 | 1.306 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.140769e-02 | 1.289 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.710282e-01 | 0.567 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.125405e-01 | 0.673 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.125405e-01 | 0.673 |
| R-HSA-162592 | Integration of provirus | 1.091331e-01 | 0.962 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.596392e-02 | 1.586 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.559346e-01 | 0.807 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 5.733031e-02 | 1.242 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.305593e-01 | 0.637 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.596861e-01 | 0.586 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.653788e-01 | 0.576 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.185928e-01 | 0.660 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.878629e-01 | 0.726 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.266871e-01 | 0.897 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.596861e-01 | 0.586 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.862160e-02 | 1.104 |
| R-HSA-9930044 | Nuclear RNA decay | 2.596861e-01 | 0.586 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 9.529468e-02 | 1.021 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.022403e-01 | 0.990 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.868224e-02 | 1.542 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.024426e-02 | 1.519 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.494011e-01 | 0.826 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.624183e-01 | 0.789 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.688526e-01 | 0.772 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.034228e-02 | 1.298 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.268893e-01 | 0.897 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.653788e-01 | 0.576 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.710282e-01 | 0.567 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.821979e-01 | 0.549 |
| R-HSA-162587 | HIV Life Cycle | 4.703300e-02 | 1.328 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.045417e-01 | 0.689 |
| R-HSA-447043 | Neurofascin interactions | 6.697495e-02 | 1.174 |
| R-HSA-9620244 | Long-term potentiation | 2.125405e-01 | 0.673 |
| R-HSA-171007 | p38MAPK events | 1.361832e-01 | 0.866 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.931978e-01 | 0.533 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.159734e-01 | 0.936 |
| R-HSA-162906 | HIV Infection | 1.241798e-01 | 0.906 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.611448e-01 | 0.793 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.140769e-02 | 1.289 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.140769e-02 | 1.289 |
| R-HSA-525793 | Myogenesis | 2.185928e-01 | 0.660 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 6.697495e-02 | 1.174 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 8.124304e-02 | 1.090 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 8.124304e-02 | 1.090 |
| R-HSA-164843 | 2-LTR circle formation | 9.529468e-02 | 1.021 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.091331e-01 | 0.962 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 1.428174e-01 | 0.845 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.494011e-01 | 0.826 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.423440e-01 | 0.616 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.362229e-01 | 0.627 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.878629e-01 | 0.726 |
| R-HSA-2028269 | Signaling by Hippo | 1.559346e-01 | 0.807 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 8.829571e-02 | 1.054 |
| R-HSA-351200 | Interconversion of polyamines | 1.227616e-01 | 0.911 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.494011e-01 | 0.826 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 1.559346e-01 | 0.807 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.064417e-01 | 0.685 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 8.086976e-02 | 1.092 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.364742e-01 | 0.626 |
| R-HSA-5334118 | DNA methylation | 2.364742e-01 | 0.626 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.596861e-01 | 0.586 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.766344e-01 | 0.558 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.596861e-01 | 0.586 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.815745e-01 | 0.741 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.164460e-01 | 0.665 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.029146e-02 | 1.395 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.878629e-01 | 0.726 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 2.002961e-01 | 0.698 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.125405e-01 | 0.673 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.481690e-01 | 0.605 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.710282e-01 | 0.567 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.624183e-01 | 0.789 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.752379e-01 | 0.756 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 2.653788e-01 | 0.576 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 2.766344e-01 | 0.558 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.347755e-02 | 1.197 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.423440e-01 | 0.616 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.821979e-01 | 0.549 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.291046e-02 | 1.032 |
| R-HSA-8951664 | Neddylation | 2.840645e-01 | 0.547 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.975870e-02 | 1.224 |
| R-HSA-447041 | CHL1 interactions | 7.413626e-02 | 1.130 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 8.829571e-02 | 1.054 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.022403e-01 | 0.990 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.428174e-01 | 0.845 |
| R-HSA-167044 | Signalling to RAS | 1.815745e-01 | 0.741 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.539496e-01 | 0.595 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.596861e-01 | 0.586 |
| R-HSA-2142845 | Hyaluronan metabolism | 2.710282e-01 | 0.567 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.051404e-01 | 0.978 |
| R-HSA-373760 | L1CAM interactions | 7.974768e-02 | 1.098 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.361832e-01 | 0.866 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.692769e-01 | 0.771 |
| R-HSA-201451 | Signaling by BMP | 2.245989e-01 | 0.649 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.559346e-01 | 0.807 |
| R-HSA-2160916 | Hyaluronan degradation | 2.125405e-01 | 0.673 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.185928e-01 | 0.660 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.019274e-02 | 1.299 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.760716e-02 | 1.425 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.353090e-01 | 0.869 |
| R-HSA-397014 | Muscle contraction | 2.653455e-01 | 0.576 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.003960e-02 | 1.698 |
| R-HSA-198753 | ERK/MAPK targets | 1.815745e-01 | 0.741 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.263462e-01 | 0.898 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.557653e-01 | 0.808 |
| R-HSA-397795 | G-protein beta:gamma signalling | 2.596861e-01 | 0.586 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.624183e-01 | 0.789 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.364742e-01 | 0.626 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.268893e-01 | 0.897 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.022403e-01 | 0.990 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.029146e-02 | 1.395 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.423440e-01 | 0.616 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.809434e-02 | 1.551 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.596861e-01 | 0.586 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.653788e-01 | 0.576 |
| R-HSA-391251 | Protein folding | 1.857392e-01 | 0.731 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.268893e-01 | 0.897 |
| R-HSA-392518 | Signal amplification | 2.710282e-01 | 0.567 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.477088e-01 | 0.831 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.829571e-02 | 1.054 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.185928e-01 | 0.660 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.986348e-01 | 0.525 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.426997e-01 | 0.615 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.638474e-01 | 0.786 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.373608e-02 | 1.196 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.688526e-01 | 0.772 |
| R-HSA-216083 | Integrin cell surface interactions | 1.424798e-01 | 0.846 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.752379e-01 | 0.756 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.596861e-01 | 0.586 |
| R-HSA-392499 | Metabolism of proteins | 2.374906e-01 | 0.624 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.917964e-02 | 1.407 |
| R-HSA-187687 | Signalling to ERKs | 2.766344e-01 | 0.558 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.323389e-02 | 1.634 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.158087e-02 | 1.381 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 2.244301e-01 | 0.649 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.948575e-02 | 1.306 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 5.248709e-02 | 1.280 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.674734e-01 | 0.573 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.710282e-01 | 0.567 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 2.821979e-01 | 0.549 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.674734e-01 | 0.573 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.483751e-02 | 1.458 |
| R-HSA-8964038 | LDL clearance | 1.941033e-01 | 0.712 |
| R-HSA-168268 | Virus Assembly and Release | 1.428174e-01 | 0.845 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 9.005655e-02 | 1.045 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.931978e-01 | 0.533 |
| R-HSA-201556 | Signaling by ALK | 2.986348e-01 | 0.525 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.140433e-02 | 1.212 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.586212e-01 | 0.800 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.197969e-02 | 1.658 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.617848e-01 | 0.582 |
| R-HSA-194138 | Signaling by VEGF | 2.930529e-01 | 0.533 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.986348e-01 | 0.525 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.539496e-01 | 0.595 |
| R-HSA-212436 | Generic Transcription Pathway | 3.254642e-02 | 1.487 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.024186e-01 | 0.694 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.199397e-01 | 0.921 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.116528e-02 | 1.091 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.987050e-01 | 0.525 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.040304e-01 | 0.517 |
| R-HSA-1280218 | Adaptive Immune System | 3.070329e-01 | 0.513 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.093848e-01 | 0.510 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.093848e-01 | 0.510 |
| R-HSA-597592 | Post-translational protein modification | 3.122068e-01 | 0.506 |
| R-HSA-9843745 | Adipogenesis | 3.128747e-01 | 0.505 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.146984e-01 | 0.502 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.146984e-01 | 0.502 |
| R-HSA-9909396 | Circadian clock | 3.156979e-01 | 0.501 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 3.156979e-01 | 0.501 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.199714e-01 | 0.495 |
| R-HSA-112316 | Neuronal System | 3.247362e-01 | 0.488 |
| R-HSA-9710421 | Defective pyroptosis | 3.252041e-01 | 0.488 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.297739e-01 | 0.482 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.303969e-01 | 0.481 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.355501e-01 | 0.474 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.355501e-01 | 0.474 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.355501e-01 | 0.474 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.406639e-01 | 0.468 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.406639e-01 | 0.468 |
| R-HSA-9675135 | Diseases of DNA repair | 3.406639e-01 | 0.468 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.406639e-01 | 0.468 |
| R-HSA-75153 | Apoptotic execution phase | 3.406639e-01 | 0.468 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.457387e-01 | 0.461 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.493460e-01 | 0.457 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.507748e-01 | 0.455 |
| R-HSA-9766229 | Degradation of CDH1 | 3.557723e-01 | 0.449 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.557723e-01 | 0.449 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.607318e-01 | 0.443 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.616766e-01 | 0.442 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.629131e-01 | 0.440 |
| R-HSA-9864848 | Complex IV assembly | 3.656533e-01 | 0.437 |
| R-HSA-912446 | Meiotic recombination | 3.656533e-01 | 0.437 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.705373e-01 | 0.431 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.705373e-01 | 0.431 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.753839e-01 | 0.426 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.753839e-01 | 0.426 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.753839e-01 | 0.426 |
| R-HSA-1221632 | Meiotic synapsis | 3.753839e-01 | 0.426 |
| R-HSA-72649 | Translation initiation complex formation | 3.801936e-01 | 0.420 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.801936e-01 | 0.420 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.801936e-01 | 0.420 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.825564e-01 | 0.417 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.849665e-01 | 0.415 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.849665e-01 | 0.415 |
| R-HSA-1989781 | PPARA activates gene expression | 3.851621e-01 | 0.414 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.897029e-01 | 0.409 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.897029e-01 | 0.409 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.897029e-01 | 0.409 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.906004e-01 | 0.408 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.944031e-01 | 0.404 |
| R-HSA-5621480 | Dectin-2 family | 3.944031e-01 | 0.404 |
| R-HSA-877300 | Interferon gamma signaling | 3.960175e-01 | 0.402 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.990675e-01 | 0.399 |
| R-HSA-191859 | snRNP Assembly | 4.036962e-01 | 0.394 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.036962e-01 | 0.394 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.036962e-01 | 0.394 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.036962e-01 | 0.394 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.053528e-01 | 0.392 |
| R-HSA-2262752 | Cellular responses to stress | 4.075085e-01 | 0.390 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.082895e-01 | 0.389 |
| R-HSA-379724 | tRNA Aminoacylation | 4.082895e-01 | 0.389 |
| R-HSA-351202 | Metabolism of polyamines | 4.082895e-01 | 0.389 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.082895e-01 | 0.389 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.094640e-01 | 0.388 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.096157e-01 | 0.388 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.128478e-01 | 0.384 |
| R-HSA-450294 | MAP kinase activation | 4.128478e-01 | 0.384 |
| R-HSA-112043 | PLC beta mediated events | 4.128478e-01 | 0.384 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.173712e-01 | 0.379 |
| R-HSA-9707616 | Heme signaling | 4.173712e-01 | 0.379 |
| R-HSA-186797 | Signaling by PDGF | 4.173712e-01 | 0.379 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.218600e-01 | 0.375 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.218600e-01 | 0.375 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.218600e-01 | 0.375 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.263146e-01 | 0.370 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.307350e-01 | 0.366 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.394749e-01 | 0.357 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.394749e-01 | 0.357 |
| R-HSA-112040 | G-protein mediated events | 4.394749e-01 | 0.357 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.394749e-01 | 0.357 |
| R-HSA-913709 | O-linked glycosylation of mucins | 4.437948e-01 | 0.353 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.437948e-01 | 0.353 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.453574e-01 | 0.351 |
| R-HSA-168255 | Influenza Infection | 4.514791e-01 | 0.345 |
| R-HSA-448424 | Interleukin-17 signaling | 4.523357e-01 | 0.345 |
| R-HSA-2559583 | Cellular Senescence | 4.540500e-01 | 0.343 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.565573e-01 | 0.341 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.565573e-01 | 0.341 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.565573e-01 | 0.341 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.565573e-01 | 0.341 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.565573e-01 | 0.341 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.565573e-01 | 0.341 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.607466e-01 | 0.337 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.649038e-01 | 0.333 |
| R-HSA-4086398 | Ca2+ pathway | 4.649038e-01 | 0.333 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.690292e-01 | 0.329 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.690292e-01 | 0.329 |
| R-HSA-8852135 | Protein ubiquitination | 4.731231e-01 | 0.325 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.743689e-01 | 0.324 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.852179e-01 | 0.314 |
| R-HSA-9659379 | Sensory processing of sound | 4.891880e-01 | 0.311 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.891880e-01 | 0.311 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.931276e-01 | 0.307 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.931276e-01 | 0.307 |
| R-HSA-9833482 | PKR-mediated signaling | 4.931276e-01 | 0.307 |
| R-HSA-6806834 | Signaling by MET | 4.931276e-01 | 0.307 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.970372e-01 | 0.304 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.970372e-01 | 0.304 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.009168e-01 | 0.300 |
| R-HSA-1500620 | Meiosis | 5.123785e-01 | 0.290 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.123785e-01 | 0.290 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.198742e-01 | 0.284 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.235791e-01 | 0.281 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.272556e-01 | 0.278 |
| R-HSA-9824446 | Viral Infection Pathways | 5.272746e-01 | 0.278 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.309039e-01 | 0.275 |
| R-HSA-1643685 | Disease | 5.346195e-01 | 0.272 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.416823e-01 | 0.266 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.426682e-01 | 0.265 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.452202e-01 | 0.263 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.487310e-01 | 0.261 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.522149e-01 | 0.258 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 5.556721e-01 | 0.255 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.591029e-01 | 0.253 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.625074e-01 | 0.250 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.692383e-01 | 0.245 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.692383e-01 | 0.245 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.692383e-01 | 0.245 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.692383e-01 | 0.245 |
| R-HSA-422356 | Regulation of insulin secretion | 5.692383e-01 | 0.245 |
| R-HSA-190236 | Signaling by FGFR | 5.692383e-01 | 0.245 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.725652e-01 | 0.242 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.758665e-01 | 0.240 |
| R-HSA-72312 | rRNA processing | 5.797195e-01 | 0.237 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.823936e-01 | 0.235 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.823936e-01 | 0.235 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.823936e-01 | 0.235 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.840307e-01 | 0.234 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.888209e-01 | 0.230 |
| R-HSA-111885 | Opioid Signalling | 5.888209e-01 | 0.230 |
| R-HSA-8939211 | ESR-mediated signaling | 5.904371e-01 | 0.229 |
| R-HSA-109582 | Hemostasis | 5.904876e-01 | 0.229 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.951502e-01 | 0.225 |
| R-HSA-418346 | Platelet homeostasis | 5.982785e-01 | 0.223 |
| R-HSA-69239 | Synthesis of DNA | 6.013828e-01 | 0.221 |
| R-HSA-913531 | Interferon Signaling | 6.042526e-01 | 0.219 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.044633e-01 | 0.219 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.044633e-01 | 0.219 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.044633e-01 | 0.219 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.044633e-01 | 0.219 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.075202e-01 | 0.216 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.075202e-01 | 0.216 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.105536e-01 | 0.214 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.105536e-01 | 0.214 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.105536e-01 | 0.214 |
| R-HSA-6803157 | Antimicrobial peptides | 6.135638e-01 | 0.212 |
| R-HSA-4839726 | Chromatin organization | 6.153344e-01 | 0.211 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.165509e-01 | 0.210 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.195152e-01 | 0.208 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.224566e-01 | 0.206 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.224566e-01 | 0.206 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.253756e-01 | 0.204 |
| R-HSA-5688426 | Deubiquitination | 6.273467e-01 | 0.202 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.282721e-01 | 0.202 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.282721e-01 | 0.202 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.339987e-01 | 0.198 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.339987e-01 | 0.198 |
| R-HSA-5693538 | Homology Directed Repair | 6.396378e-01 | 0.194 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.424249e-01 | 0.192 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.424249e-01 | 0.192 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.429124e-01 | 0.192 |
| R-HSA-68875 | Mitotic Prophase | 6.451906e-01 | 0.190 |
| R-HSA-3371556 | Cellular response to heat stress | 6.479352e-01 | 0.188 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.506586e-01 | 0.187 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.506586e-01 | 0.187 |
| R-HSA-9679506 | SARS-CoV Infections | 6.512059e-01 | 0.186 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.560430e-01 | 0.183 |
| R-HSA-69481 | G2/M Checkpoints | 6.665661e-01 | 0.176 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.691466e-01 | 0.174 |
| R-HSA-1474165 | Reproduction | 6.767697e-01 | 0.170 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.938862e-01 | 0.159 |
| R-HSA-163685 | Integration of energy metabolism | 6.938862e-01 | 0.159 |
| R-HSA-5173105 | O-linked glycosylation | 6.962569e-01 | 0.157 |
| R-HSA-195721 | Signaling by WNT | 7.050730e-01 | 0.152 |
| R-HSA-1632852 | Macroautophagy | 7.055588e-01 | 0.151 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.123493e-01 | 0.147 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.129571e-01 | 0.147 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.233232e-01 | 0.141 |
| R-HSA-166520 | Signaling by NTRKs | 7.233232e-01 | 0.141 |
| R-HSA-69242 | S Phase | 7.233232e-01 | 0.141 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.275956e-01 | 0.138 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.275956e-01 | 0.138 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.297072e-01 | 0.137 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.338818e-01 | 0.134 |
| R-HSA-69306 | DNA Replication | 7.338818e-01 | 0.134 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.359450e-01 | 0.133 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.379924e-01 | 0.132 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.393904e-01 | 0.131 |
| R-HSA-9612973 | Autophagy | 7.400240e-01 | 0.131 |
| R-HSA-8957322 | Metabolism of steroids | 7.452544e-01 | 0.128 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.479955e-01 | 0.126 |
| R-HSA-109581 | Apoptosis | 7.518898e-01 | 0.124 |
| R-HSA-1474244 | Extracellular matrix organization | 7.552470e-01 | 0.122 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.557244e-01 | 0.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.686883e-01 | 0.114 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.704837e-01 | 0.113 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.740332e-01 | 0.111 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.740332e-01 | 0.111 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.740332e-01 | 0.111 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.740332e-01 | 0.111 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.740332e-01 | 0.111 |
| R-HSA-5663205 | Infectious disease | 7.784110e-01 | 0.109 |
| R-HSA-611105 | Respiratory electron transport | 7.826704e-01 | 0.106 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.909800e-01 | 0.102 |
| R-HSA-3781865 | Diseases of glycosylation | 7.926037e-01 | 0.101 |
| R-HSA-73894 | DNA Repair | 7.931428e-01 | 0.101 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.967550e-01 | 0.099 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.036245e-01 | 0.095 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.111390e-01 | 0.091 |
| R-HSA-422475 | Axon guidance | 8.149644e-01 | 0.089 |
| R-HSA-1640170 | Cell Cycle | 8.173185e-01 | 0.088 |
| R-HSA-428157 | Sphingolipid metabolism | 8.183681e-01 | 0.087 |
| R-HSA-68886 | M Phase | 8.194510e-01 | 0.086 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.211823e-01 | 0.086 |
| R-HSA-5357801 | Programmed Cell Death | 8.253227e-01 | 0.083 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.349684e-01 | 0.078 |
| R-HSA-68882 | Mitotic Anaphase | 8.397066e-01 | 0.076 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.409545e-01 | 0.075 |
| R-HSA-418990 | Adherens junctions interactions | 8.421927e-01 | 0.075 |
| R-HSA-1266738 | Developmental Biology | 8.422760e-01 | 0.075 |
| R-HSA-9675108 | Nervous system development | 8.471099e-01 | 0.072 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.517602e-01 | 0.070 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.639826e-01 | 0.063 |
| R-HSA-72766 | Translation | 8.641433e-01 | 0.063 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.736643e-01 | 0.059 |
| R-HSA-421270 | Cell-cell junction organization | 8.781026e-01 | 0.056 |
| R-HSA-6798695 | Neutrophil degranulation | 8.857423e-01 | 0.053 |
| R-HSA-416476 | G alpha (q) signalling events | 8.899077e-01 | 0.051 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.982104e-01 | 0.047 |
| R-HSA-446728 | Cell junction organization | 9.013549e-01 | 0.045 |
| R-HSA-9658195 | Leishmania infection | 9.036498e-01 | 0.044 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.036498e-01 | 0.044 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.095138e-01 | 0.041 |
| R-HSA-1483257 | Phospholipid metabolism | 9.136782e-01 | 0.039 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.143536e-01 | 0.039 |
| R-HSA-162582 | Signal Transduction | 9.185489e-01 | 0.037 |
| R-HSA-1500931 | Cell-Cell communication | 9.268116e-01 | 0.033 |
| R-HSA-168256 | Immune System | 9.274410e-01 | 0.033 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.398845e-01 | 0.027 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.426601e-01 | 0.026 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.430557e-01 | 0.025 |
| R-HSA-382551 | Transport of small molecules | 9.537164e-01 | 0.021 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.594802e-01 | 0.018 |
| R-HSA-418594 | G alpha (i) signalling events | 9.645763e-01 | 0.016 |
| R-HSA-8978868 | Fatty acid metabolism | 9.645763e-01 | 0.016 |
| R-HSA-5668914 | Diseases of metabolism | 9.697630e-01 | 0.013 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.724056e-01 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 9.790363e-01 | 0.009 |
| R-HSA-449147 | Signaling by Interleukins | 9.937615e-01 | 0.003 |
| R-HSA-168249 | Innate Immune System | 9.939547e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.981231e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.990435e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999287e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999584e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.827 | 0.705 | 2 | 0.918 |
CK2A2 |
0.779 | 0.458 | 1 | 0.785 |
CK2A1 |
0.770 | 0.431 | 1 | 0.761 |
COT |
0.769 | 0.088 | 2 | 0.472 |
CDC7 |
0.765 | 0.062 | 1 | 0.854 |
CAMK2G |
0.765 | 0.181 | 2 | 0.512 |
MOS |
0.764 | 0.138 | 1 | 0.890 |
CLK3 |
0.762 | 0.114 | 1 | 0.815 |
GRK1 |
0.762 | 0.159 | -2 | 0.647 |
GRK6 |
0.760 | 0.226 | 1 | 0.770 |
CAMK2B |
0.756 | 0.236 | 2 | 0.571 |
DSTYK |
0.756 | 0.112 | 2 | 0.496 |
PLK3 |
0.755 | 0.221 | 2 | 0.475 |
GRK7 |
0.754 | 0.241 | 1 | 0.689 |
BMPR1B |
0.753 | 0.145 | 1 | 0.752 |
PRPK |
0.752 | -0.019 | -1 | 0.823 |
KIS |
0.751 | 0.033 | 1 | 0.677 |
PIM3 |
0.750 | 0.026 | -3 | 0.752 |
IKKB |
0.750 | 0.021 | -2 | 0.571 |
GRK4 |
0.749 | 0.065 | -2 | 0.703 |
ATM |
0.749 | 0.108 | 1 | 0.730 |
CAMK1B |
0.748 | 0.001 | -3 | 0.782 |
IKKA |
0.748 | 0.087 | -2 | 0.565 |
TGFBR1 |
0.747 | 0.133 | -2 | 0.675 |
GRK5 |
0.747 | 0.039 | -3 | 0.833 |
BMPR2 |
0.747 | 0.037 | -2 | 0.754 |
NDR2 |
0.746 | -0.011 | -3 | 0.736 |
PDHK4 |
0.746 | -0.003 | 1 | 0.794 |
ALK2 |
0.746 | 0.191 | -2 | 0.691 |
ATR |
0.745 | 0.005 | 1 | 0.784 |
BMPR1A |
0.744 | 0.142 | 1 | 0.748 |
RSK2 |
0.744 | 0.036 | -3 | 0.674 |
GCN2 |
0.744 | -0.135 | 2 | 0.374 |
LATS1 |
0.744 | 0.192 | -3 | 0.744 |
MARK4 |
0.744 | 0.009 | 4 | 0.809 |
ACVR2A |
0.743 | 0.154 | -2 | 0.743 |
CAMK2A |
0.743 | 0.126 | 2 | 0.503 |
PLK1 |
0.743 | 0.132 | -2 | 0.724 |
TBK1 |
0.742 | -0.064 | 1 | 0.649 |
ACVR2B |
0.742 | 0.141 | -2 | 0.735 |
HUNK |
0.741 | -0.089 | 2 | 0.408 |
SKMLCK |
0.741 | 0.004 | -2 | 0.682 |
MTOR |
0.741 | -0.102 | 1 | 0.732 |
PLK2 |
0.741 | 0.175 | -3 | 0.869 |
SRPK1 |
0.741 | 0.033 | -3 | 0.682 |
CDKL1 |
0.740 | -0.020 | -3 | 0.746 |
PIM1 |
0.739 | 0.042 | -3 | 0.695 |
RAF1 |
0.739 | -0.141 | 1 | 0.769 |
TSSK2 |
0.739 | 0.016 | -5 | 0.812 |
IKKE |
0.739 | -0.062 | 1 | 0.643 |
MAPKAPK2 |
0.738 | 0.081 | -3 | 0.627 |
TGFBR2 |
0.738 | -0.027 | -2 | 0.735 |
CAMK2D |
0.737 | 0.076 | -3 | 0.740 |
NLK |
0.737 | -0.093 | 1 | 0.790 |
CAMLCK |
0.736 | -0.039 | -2 | 0.677 |
SRPK2 |
0.736 | 0.036 | -3 | 0.621 |
ALK4 |
0.736 | 0.041 | -2 | 0.695 |
HIPK4 |
0.736 | -0.033 | 1 | 0.782 |
PKN3 |
0.735 | -0.044 | -3 | 0.750 |
LATS2 |
0.735 | 0.021 | -5 | 0.788 |
ULK2 |
0.735 | -0.175 | 2 | 0.378 |
ERK5 |
0.735 | -0.075 | 1 | 0.734 |
SRPK3 |
0.735 | 0.030 | -3 | 0.692 |
PRKD1 |
0.735 | -0.028 | -3 | 0.701 |
NEK6 |
0.734 | -0.076 | -2 | 0.750 |
NEK7 |
0.734 | -0.121 | -3 | 0.809 |
TTBK2 |
0.734 | -0.074 | 2 | 0.336 |
P90RSK |
0.734 | -0.011 | -3 | 0.688 |
PDHK1 |
0.734 | -0.143 | 1 | 0.772 |
CLK2 |
0.733 | 0.067 | -3 | 0.665 |
MLK1 |
0.733 | -0.129 | 2 | 0.383 |
JNK3 |
0.733 | 0.052 | 1 | 0.643 |
AMPKA1 |
0.732 | -0.051 | -3 | 0.736 |
NDR1 |
0.732 | -0.074 | -3 | 0.732 |
NUAK2 |
0.731 | -0.076 | -3 | 0.733 |
RSK4 |
0.731 | 0.035 | -3 | 0.648 |
ULK1 |
0.731 | -0.145 | -3 | 0.781 |
RIPK3 |
0.731 | -0.158 | 3 | 0.449 |
TSSK1 |
0.731 | -0.027 | -3 | 0.740 |
NIK |
0.730 | -0.145 | -3 | 0.798 |
CDK8 |
0.730 | -0.004 | 1 | 0.655 |
GSK3A |
0.730 | 0.094 | 4 | 0.571 |
WNK1 |
0.729 | -0.109 | -2 | 0.703 |
MARK2 |
0.729 | 0.017 | 4 | 0.745 |
CDKL5 |
0.729 | -0.046 | -3 | 0.724 |
DAPK2 |
0.729 | -0.075 | -3 | 0.781 |
DNAPK |
0.729 | 0.088 | 1 | 0.660 |
CHAK2 |
0.729 | -0.121 | -1 | 0.836 |
MARK3 |
0.728 | -0.000 | 4 | 0.769 |
NIM1 |
0.728 | -0.113 | 3 | 0.529 |
BRSK1 |
0.728 | -0.024 | -3 | 0.698 |
DYRK2 |
0.728 | 0.008 | 1 | 0.694 |
RSK3 |
0.728 | -0.039 | -3 | 0.690 |
P70S6KB |
0.728 | -0.041 | -3 | 0.707 |
BCKDK |
0.728 | -0.089 | -1 | 0.751 |
PRKD2 |
0.727 | -0.031 | -3 | 0.638 |
JNK2 |
0.727 | 0.040 | 1 | 0.604 |
ICK |
0.727 | -0.042 | -3 | 0.757 |
PKACG |
0.727 | -0.034 | -2 | 0.583 |
WNK3 |
0.726 | -0.201 | 1 | 0.752 |
AMPKA2 |
0.725 | -0.055 | -3 | 0.701 |
MAPKAPK3 |
0.725 | -0.021 | -3 | 0.663 |
TLK2 |
0.725 | -0.010 | 1 | 0.742 |
GRK2 |
0.725 | -0.009 | -2 | 0.575 |
PAK1 |
0.724 | -0.066 | -2 | 0.607 |
PRKX |
0.724 | 0.038 | -3 | 0.564 |
MASTL |
0.724 | -0.216 | -2 | 0.638 |
MSK1 |
0.724 | 0.012 | -3 | 0.675 |
PKCD |
0.724 | -0.094 | 2 | 0.362 |
RIPK1 |
0.723 | -0.162 | 1 | 0.747 |
MST4 |
0.723 | -0.122 | 2 | 0.402 |
DLK |
0.723 | -0.143 | 1 | 0.747 |
DYRK4 |
0.723 | 0.035 | 1 | 0.629 |
MARK1 |
0.722 | -0.009 | 4 | 0.774 |
MSK2 |
0.722 | -0.024 | -3 | 0.679 |
GSK3B |
0.722 | 0.049 | 4 | 0.561 |
MLK3 |
0.722 | -0.120 | 2 | 0.333 |
QSK |
0.722 | -0.052 | 4 | 0.782 |
CLK4 |
0.721 | -0.011 | -3 | 0.679 |
MEK1 |
0.721 | -0.099 | 2 | 0.431 |
GRK3 |
0.721 | 0.024 | -2 | 0.537 |
PKR |
0.721 | -0.086 | 1 | 0.800 |
CDK19 |
0.721 | -0.020 | 1 | 0.620 |
CDK1 |
0.721 | -0.002 | 1 | 0.623 |
SSTK |
0.721 | -0.009 | 4 | 0.771 |
ANKRD3 |
0.720 | -0.185 | 1 | 0.774 |
SMG1 |
0.720 | -0.035 | 1 | 0.743 |
MLK4 |
0.720 | -0.099 | 2 | 0.330 |
JNK1 |
0.719 | 0.040 | 1 | 0.602 |
AURC |
0.719 | -0.054 | -2 | 0.530 |
PKACB |
0.719 | -0.008 | -2 | 0.535 |
PKN2 |
0.719 | -0.145 | -3 | 0.739 |
MYLK4 |
0.719 | -0.042 | -2 | 0.602 |
PASK |
0.719 | 0.032 | -3 | 0.770 |
TLK1 |
0.718 | -0.026 | -2 | 0.732 |
AURA |
0.717 | -0.029 | -2 | 0.481 |
SIK |
0.716 | -0.063 | -3 | 0.669 |
CK1E |
0.716 | -0.024 | -3 | 0.557 |
IRE2 |
0.716 | -0.151 | 2 | 0.345 |
VRK2 |
0.716 | -0.263 | 1 | 0.817 |
P38D |
0.715 | 0.024 | 1 | 0.579 |
IRE1 |
0.715 | -0.190 | 1 | 0.753 |
NEK9 |
0.715 | -0.234 | 2 | 0.378 |
PERK |
0.715 | -0.077 | -2 | 0.755 |
P38B |
0.715 | 0.012 | 1 | 0.603 |
PRKD3 |
0.715 | -0.053 | -3 | 0.649 |
BRSK2 |
0.714 | -0.091 | -3 | 0.707 |
PLK4 |
0.714 | -0.085 | 2 | 0.321 |
PAK2 |
0.714 | -0.102 | -2 | 0.586 |
CAMK4 |
0.714 | -0.128 | -3 | 0.716 |
CLK1 |
0.714 | -0.030 | -3 | 0.648 |
PAK3 |
0.714 | -0.132 | -2 | 0.600 |
QIK |
0.714 | -0.136 | -3 | 0.740 |
CAMK1G |
0.713 | -0.054 | -3 | 0.681 |
TTBK1 |
0.713 | -0.087 | 2 | 0.307 |
AURB |
0.713 | -0.063 | -2 | 0.511 |
P38A |
0.712 | -0.023 | 1 | 0.670 |
P38G |
0.712 | 0.006 | 1 | 0.540 |
HIPK2 |
0.712 | -0.003 | 1 | 0.621 |
NUAK1 |
0.711 | -0.107 | -3 | 0.696 |
CDK5 |
0.711 | -0.039 | 1 | 0.686 |
CDK7 |
0.711 | -0.047 | 1 | 0.671 |
ERK1 |
0.711 | -0.025 | 1 | 0.597 |
CDK2 |
0.711 | -0.058 | 1 | 0.684 |
ERK2 |
0.710 | -0.037 | 1 | 0.643 |
MELK |
0.710 | -0.130 | -3 | 0.685 |
MLK2 |
0.710 | -0.248 | 2 | 0.379 |
MEKK3 |
0.710 | -0.122 | 1 | 0.710 |
BRAF |
0.710 | -0.066 | -4 | 0.759 |
CAMK1D |
0.710 | 0.014 | -3 | 0.605 |
HIPK1 |
0.710 | -0.021 | 1 | 0.706 |
PINK1 |
0.710 | -0.134 | 1 | 0.805 |
CK1D |
0.710 | -0.006 | -3 | 0.511 |
DYRK1A |
0.709 | -0.025 | 1 | 0.723 |
PKCB |
0.709 | -0.121 | 2 | 0.315 |
YSK4 |
0.709 | -0.161 | 1 | 0.686 |
CDK13 |
0.709 | -0.043 | 1 | 0.643 |
PKG2 |
0.709 | -0.057 | -2 | 0.548 |
PIM2 |
0.709 | -0.027 | -3 | 0.660 |
DRAK1 |
0.709 | -0.103 | 1 | 0.675 |
CK1G1 |
0.708 | -0.051 | -3 | 0.585 |
DYRK1B |
0.708 | 0.005 | 1 | 0.651 |
PRP4 |
0.708 | -0.051 | -3 | 0.664 |
CHK1 |
0.707 | -0.054 | -3 | 0.714 |
PKCG |
0.707 | -0.139 | 2 | 0.324 |
GAK |
0.707 | -0.001 | 1 | 0.786 |
MAPKAPK5 |
0.707 | -0.070 | -3 | 0.662 |
CHAK1 |
0.707 | -0.224 | 2 | 0.335 |
NEK2 |
0.707 | -0.175 | 2 | 0.354 |
PKCA |
0.707 | -0.133 | 2 | 0.314 |
PKACA |
0.706 | -0.014 | -2 | 0.507 |
CDK3 |
0.706 | -0.008 | 1 | 0.570 |
PKCH |
0.706 | -0.142 | 2 | 0.311 |
SGK3 |
0.706 | -0.061 | -3 | 0.665 |
HRI |
0.706 | -0.135 | -2 | 0.762 |
AKT2 |
0.705 | -0.044 | -3 | 0.604 |
DCAMKL1 |
0.705 | -0.082 | -3 | 0.661 |
SNRK |
0.705 | -0.210 | 2 | 0.329 |
CK1A2 |
0.704 | -0.027 | -3 | 0.510 |
MEKK2 |
0.704 | -0.159 | 2 | 0.371 |
MNK1 |
0.704 | -0.109 | -2 | 0.630 |
PAK6 |
0.703 | -0.088 | -2 | 0.531 |
MNK2 |
0.702 | -0.123 | -2 | 0.615 |
CDK18 |
0.702 | -0.039 | 1 | 0.600 |
DYRK3 |
0.702 | -0.022 | 1 | 0.712 |
ERK7 |
0.701 | -0.063 | 2 | 0.225 |
SMMLCK |
0.701 | -0.079 | -3 | 0.742 |
MEK5 |
0.700 | -0.277 | 2 | 0.395 |
DCAMKL2 |
0.700 | -0.100 | -3 | 0.687 |
CDK17 |
0.700 | -0.034 | 1 | 0.551 |
CDK12 |
0.699 | -0.048 | 1 | 0.614 |
PDHK3_TYR |
0.699 | 0.169 | 4 | 0.819 |
WNK4 |
0.699 | -0.176 | -2 | 0.692 |
CDK9 |
0.699 | -0.062 | 1 | 0.645 |
ALPHAK3 |
0.699 | 0.127 | -1 | 0.742 |
DAPK3 |
0.698 | -0.027 | -3 | 0.700 |
P70S6K |
0.698 | -0.068 | -3 | 0.635 |
HIPK3 |
0.698 | -0.066 | 1 | 0.688 |
PKCZ |
0.697 | -0.178 | 2 | 0.343 |
MEKK1 |
0.697 | -0.234 | 1 | 0.735 |
CDK16 |
0.695 | -0.024 | 1 | 0.569 |
DAPK1 |
0.695 | -0.027 | -3 | 0.693 |
CAMKK1 |
0.694 | -0.151 | -2 | 0.603 |
ZAK |
0.694 | -0.218 | 1 | 0.692 |
NEK5 |
0.694 | -0.229 | 1 | 0.760 |
IRAK1 |
0.693 | -0.181 | -1 | 0.720 |
PHKG1 |
0.693 | -0.198 | -3 | 0.712 |
NEK8 |
0.693 | -0.202 | 2 | 0.374 |
MPSK1 |
0.692 | -0.111 | 1 | 0.747 |
IRAK4 |
0.692 | -0.228 | 1 | 0.745 |
CDK14 |
0.692 | -0.058 | 1 | 0.634 |
YANK3 |
0.692 | -0.051 | 2 | 0.247 |
MAP2K6_TYR |
0.692 | 0.125 | -1 | 0.833 |
SGK1 |
0.691 | -0.009 | -3 | 0.538 |
PDHK4_TYR |
0.691 | 0.115 | 2 | 0.478 |
CAMKK2 |
0.691 | -0.145 | -2 | 0.596 |
TAO3 |
0.690 | -0.166 | 1 | 0.713 |
CDK10 |
0.690 | -0.043 | 1 | 0.626 |
PDHK1_TYR |
0.690 | 0.094 | -1 | 0.863 |
AKT1 |
0.690 | -0.067 | -3 | 0.603 |
EEF2K |
0.689 | -0.137 | 3 | 0.528 |
BMPR2_TYR |
0.689 | 0.076 | -1 | 0.833 |
MST3 |
0.689 | -0.203 | 2 | 0.369 |
SBK |
0.688 | 0.020 | -3 | 0.488 |
MST2 |
0.688 | -0.133 | 1 | 0.718 |
LKB1 |
0.688 | -0.167 | -3 | 0.756 |
PKCT |
0.688 | -0.156 | 2 | 0.312 |
STK33 |
0.688 | -0.147 | 2 | 0.309 |
PDK1 |
0.687 | -0.155 | 1 | 0.726 |
CAMK1A |
0.686 | -0.045 | -3 | 0.570 |
TAK1 |
0.686 | -0.161 | 1 | 0.750 |
PKCE |
0.686 | -0.109 | 2 | 0.312 |
PAK4 |
0.686 | -0.101 | -2 | 0.473 |
MAP2K4_TYR |
0.685 | 0.002 | -1 | 0.832 |
MAK |
0.685 | -0.008 | -2 | 0.600 |
PAK5 |
0.685 | -0.109 | -2 | 0.467 |
EPHA4 |
0.685 | 0.064 | 2 | 0.490 |
MRCKA |
0.685 | -0.052 | -3 | 0.663 |
TAO2 |
0.685 | -0.202 | 2 | 0.407 |
TTK |
0.685 | -0.001 | -2 | 0.759 |
PKCI |
0.684 | -0.155 | 2 | 0.319 |
TESK1_TYR |
0.684 | -0.074 | 3 | 0.587 |
EPHA6 |
0.684 | 0.016 | -1 | 0.844 |
PHKG2 |
0.683 | -0.171 | -3 | 0.677 |
MRCKB |
0.683 | -0.055 | -3 | 0.646 |
ROCK2 |
0.683 | -0.050 | -3 | 0.680 |
MAP2K7_TYR |
0.682 | -0.069 | 2 | 0.455 |
VRK1 |
0.682 | -0.228 | 2 | 0.411 |
AKT3 |
0.682 | -0.046 | -3 | 0.541 |
NEK11 |
0.681 | -0.278 | 1 | 0.703 |
GCK |
0.681 | -0.163 | 1 | 0.711 |
LRRK2 |
0.680 | -0.232 | 2 | 0.405 |
MOK |
0.680 | -0.025 | 1 | 0.708 |
MINK |
0.680 | -0.167 | 1 | 0.702 |
TXK |
0.680 | 0.057 | 1 | 0.789 |
TNIK |
0.680 | -0.153 | 3 | 0.524 |
CDK6 |
0.679 | -0.064 | 1 | 0.618 |
BUB1 |
0.679 | -0.066 | -5 | 0.754 |
EPHB4 |
0.678 | -0.034 | -1 | 0.817 |
MST1 |
0.678 | -0.161 | 1 | 0.700 |
HGK |
0.678 | -0.186 | 3 | 0.511 |
PKMYT1_TYR |
0.677 | -0.160 | 3 | 0.545 |
YES1 |
0.677 | 0.018 | -1 | 0.838 |
FYN |
0.677 | 0.083 | -1 | 0.826 |
NEK4 |
0.677 | -0.260 | 1 | 0.715 |
CK1A |
0.677 | -0.037 | -3 | 0.440 |
CDK4 |
0.677 | -0.056 | 1 | 0.607 |
DMPK1 |
0.677 | -0.035 | -3 | 0.654 |
MEK2 |
0.677 | -0.209 | 2 | 0.388 |
PINK1_TYR |
0.677 | -0.140 | 1 | 0.780 |
SRMS |
0.677 | 0.049 | 1 | 0.774 |
FER |
0.675 | -0.006 | 1 | 0.807 |
EPHB2 |
0.675 | 0.023 | -1 | 0.806 |
BLK |
0.675 | 0.031 | -1 | 0.839 |
MAP3K15 |
0.674 | -0.253 | 1 | 0.676 |
PBK |
0.674 | -0.087 | 1 | 0.720 |
INSRR |
0.674 | -0.002 | 3 | 0.452 |
SLK |
0.674 | -0.150 | -2 | 0.561 |
PKN1 |
0.673 | -0.123 | -3 | 0.629 |
CHK2 |
0.673 | -0.086 | -3 | 0.544 |
MEKK6 |
0.673 | -0.282 | 1 | 0.708 |
LOK |
0.672 | -0.195 | -2 | 0.610 |
CRIK |
0.672 | -0.028 | -3 | 0.606 |
NEK1 |
0.672 | -0.258 | 1 | 0.728 |
DDR1 |
0.672 | -0.069 | 4 | 0.755 |
RIPK2 |
0.671 | -0.244 | 1 | 0.648 |
HPK1 |
0.671 | -0.184 | 1 | 0.687 |
PKG1 |
0.670 | -0.078 | -2 | 0.500 |
HCK |
0.670 | -0.029 | -1 | 0.828 |
RET |
0.670 | -0.127 | 1 | 0.719 |
EPHB1 |
0.670 | -0.051 | 1 | 0.756 |
LCK |
0.669 | -0.012 | -1 | 0.837 |
EPHA5 |
0.668 | 0.051 | 2 | 0.499 |
ABL2 |
0.668 | -0.061 | -1 | 0.776 |
PTK2 |
0.668 | 0.050 | -1 | 0.779 |
EPHA3 |
0.668 | -0.027 | 2 | 0.459 |
LIMK2_TYR |
0.668 | -0.161 | -3 | 0.785 |
EPHB3 |
0.668 | -0.041 | -1 | 0.804 |
FGR |
0.668 | -0.078 | 1 | 0.762 |
BIKE |
0.667 | -0.022 | 1 | 0.675 |
KHS2 |
0.667 | -0.145 | 1 | 0.703 |
FGFR2 |
0.667 | -0.051 | 3 | 0.497 |
ROCK1 |
0.666 | -0.072 | -3 | 0.654 |
LIMK1_TYR |
0.666 | -0.207 | 2 | 0.435 |
EPHA7 |
0.666 | -0.016 | 2 | 0.473 |
OSR1 |
0.666 | -0.161 | 2 | 0.354 |
KHS1 |
0.665 | -0.179 | 1 | 0.692 |
CK1G3 |
0.665 | -0.019 | -3 | 0.406 |
ITK |
0.665 | -0.070 | -1 | 0.784 |
TYRO3 |
0.665 | -0.186 | 3 | 0.465 |
HASPIN |
0.664 | -0.091 | -1 | 0.635 |
ABL1 |
0.663 | -0.099 | -1 | 0.772 |
MST1R |
0.663 | -0.211 | 3 | 0.471 |
LYN |
0.663 | -0.002 | 3 | 0.415 |
EGFR |
0.663 | 0.035 | 1 | 0.577 |
MERTK |
0.663 | -0.075 | 3 | 0.469 |
SYK |
0.662 | 0.061 | -1 | 0.760 |
YSK1 |
0.661 | -0.244 | 2 | 0.347 |
CSF1R |
0.661 | -0.152 | 3 | 0.445 |
EPHA8 |
0.661 | -0.007 | -1 | 0.788 |
YANK2 |
0.661 | -0.061 | 2 | 0.268 |
SRC |
0.661 | -0.003 | -1 | 0.815 |
PTK2B |
0.660 | -0.035 | -1 | 0.775 |
TYK2 |
0.660 | -0.246 | 1 | 0.715 |
BMX |
0.660 | -0.049 | -1 | 0.703 |
TEK |
0.660 | -0.122 | 3 | 0.430 |
FGFR3 |
0.660 | -0.058 | 3 | 0.480 |
FLT3 |
0.660 | -0.126 | 3 | 0.457 |
ROS1 |
0.660 | -0.239 | 3 | 0.436 |
JAK2 |
0.660 | -0.215 | 1 | 0.708 |
TEC |
0.660 | -0.070 | -1 | 0.734 |
TNK2 |
0.659 | -0.141 | 3 | 0.441 |
JAK3 |
0.658 | -0.153 | 1 | 0.704 |
ERBB2 |
0.658 | -0.080 | 1 | 0.675 |
BTK |
0.658 | -0.099 | -1 | 0.746 |
FGFR1 |
0.658 | -0.121 | 3 | 0.462 |
KIT |
0.658 | -0.116 | 3 | 0.453 |
ASK1 |
0.657 | -0.213 | 1 | 0.667 |
FGFR4 |
0.657 | -0.002 | -1 | 0.739 |
NTRK1 |
0.656 | -0.099 | -1 | 0.776 |
DDR2 |
0.656 | -0.036 | 3 | 0.432 |
AXL |
0.656 | -0.131 | 3 | 0.458 |
FLT1 |
0.655 | -0.081 | -1 | 0.801 |
NEK3 |
0.655 | -0.258 | 1 | 0.682 |
LTK |
0.655 | -0.120 | 3 | 0.422 |
PDGFRB |
0.654 | -0.192 | 3 | 0.463 |
PTK6 |
0.654 | -0.140 | -1 | 0.698 |
KDR |
0.653 | -0.173 | 3 | 0.436 |
MET |
0.653 | -0.122 | 3 | 0.456 |
FRK |
0.653 | -0.109 | -1 | 0.833 |
CSK |
0.652 | -0.060 | 2 | 0.461 |
ERBB4 |
0.652 | 0.006 | 1 | 0.602 |
ALK |
0.652 | -0.160 | 3 | 0.405 |
INSR |
0.652 | -0.096 | 3 | 0.430 |
MYO3B |
0.650 | -0.217 | 2 | 0.367 |
MYO3A |
0.650 | -0.215 | 1 | 0.724 |
EPHA1 |
0.650 | -0.121 | 3 | 0.424 |
FLT4 |
0.649 | -0.147 | 3 | 0.444 |
CK1G2 |
0.649 | -0.035 | -3 | 0.499 |
EPHA2 |
0.649 | -0.019 | -1 | 0.749 |
IGF1R |
0.649 | -0.049 | 3 | 0.406 |
STLK3 |
0.648 | -0.187 | 1 | 0.656 |
AAK1 |
0.647 | -0.009 | 1 | 0.576 |
NTRK2 |
0.646 | -0.168 | 3 | 0.445 |
TNNI3K_TYR |
0.646 | -0.185 | 1 | 0.749 |
WEE1_TYR |
0.646 | -0.157 | -1 | 0.720 |
TNK1 |
0.645 | -0.218 | 3 | 0.462 |
NEK10_TYR |
0.645 | -0.165 | 1 | 0.599 |
PDGFRA |
0.645 | -0.258 | 3 | 0.453 |
TAO1 |
0.644 | -0.227 | 1 | 0.644 |
NTRK3 |
0.644 | -0.112 | -1 | 0.725 |
JAK1 |
0.643 | -0.215 | 1 | 0.653 |
MATK |
0.643 | -0.113 | -1 | 0.698 |
FES |
0.635 | -0.097 | -1 | 0.686 |
ZAP70 |
0.621 | -0.059 | -1 | 0.668 |
MUSK |
0.617 | -0.203 | 1 | 0.560 |