Motif 655 (n=127)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RRP1 | NBAS | S475 | ochoa | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}. |
| F8WAN1 | SPECC1L-ADORA2A | S226 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O14795 | UNC13B | S367 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15226 | NKRF | S67 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O43719 | HTATSF1 | S409 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O75554 | WBP4 | S325 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O76074 | PDE5A | S104 | ochoa|psp | cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}. |
| O94806 | PRKD3 | S254 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94806 | PRKD3 | S393 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94885 | SASH1 | S701 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95049 | TJP3 | S656 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95071 | UBR5 | S1702 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95210 | STBD1 | S57 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| P04075 | ALDOA | S132 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P08172 | CHRM2 | S288 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08238 | HSP90AB1 | S462 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09972 | ALDOC | S132 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P0DPH7 | TUBA3C | T56 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T56 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P17302 | GJA1 | S330 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P17936 | IGFBP3 | S204 | ochoa | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| P20823 | HNF1A | S249 | ochoa|psp | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
| P21359 | NF1 | S2599 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P21731 | TBXA2R | S239 | psp | Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 1]: Activates adenylyl cyclase. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 2]: Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}. |
| P23327 | HRC | S457 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P25685 | DNAJB1 | S151 | ochoa|psp | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P31947 | SFN | S209 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P38398 | BRCA1 | S1330 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42566 | EPS15 | S607 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42858 | HTT | S457 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P45974 | USP5 | S785 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46459 | NSF | S437 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P46939 | UTRN | S827 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49815 | TSC2 | S1420 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50747 | HLCS | S81 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P51825 | AFF1 | S717 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52948 | NUP98 | S681 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P55196 | AFDN | S1512 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P62258 | YWHAE | S210 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S207 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63241 | EIF5A | S46 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P68363 | TUBA1B | T56 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q02487 | DSC2 | S824 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02952 | AKAP12 | S1620 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q0ZGT2 | NEXN | S162 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12802 | AKAP13 | S1647 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13129 | RLF | S1239 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13263 | TRIM28 | S140 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13610 | PWP1 | S59 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q13976 | PRKG1 | S275 | ochoa | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q14204 | DYNC1H1 | S4370 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14324 | MYBPC2 | S62 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14574 | DSC3 | S819 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q15047 | SETDB1 | S1027 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15139 | PRKD1 | S399 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15365 | PCBP1 | S264 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q16204 | CCDC6 | S325 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16825 | PTPN21 | S660 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q53H12 | AGK | S161 | ochoa | Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase) | Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762). {ECO:0000250|UniProtKB:Q9ESW4, ECO:0000269|PubMed:15939762, ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}. |
| Q5QJE6 | DNTTIP2 | S476 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S1362 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TF21 | MTCL3 | S641 | ochoa | Microtubule cross-linking factor 3 | None |
| Q5UIP0 | RIF1 | S1976 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q69YQ0 | SPECC1L | S226 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6NUQ1 | RINT1 | S19 | ochoa | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). {ECO:0000269|PubMed:11096100, ECO:0000269|PubMed:16600870, ECO:0000305}. |
| Q6NV74 | CRACDL | S912 | ochoa | CRACD-like protein | None |
| Q6PEY2 | TUBA3E | T56 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6WKZ4 | RAB11FIP1 | S268 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZVL6 | KIAA1549L | S1683 | ochoa | UPF0606 protein KIAA1549L | None |
| Q6ZVM7 | TOM1L2 | S424 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q71U36 | TUBA1A | T56 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L0Y3 | TRMT10C | S85 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7Z2W4 | ZC3HAV1 | S494 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3T8 | ZFYVE16 | S319 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z6I6 | ARHGAP30 | S332 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86SQ0 | PHLDB2 | S982 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86X02 | CDR2L | S419 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IWU2 | LMTK2 | S1310 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IX03 | WWC1 | S654 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IZQ1 | WDFY3 | S3328 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N1F7 | NUP93 | S82 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N3F8 | MICALL1 | S538 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8NC44 | RETREG2 | S283 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8TDJ6 | DMXL2 | S1402 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TER5 | ARHGEF40 | S421 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TEW8 | PARD3B | S92 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF44 | C2CD4C | S74 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q92766 | RREB1 | S1273 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92786 | PROX1 | S179 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92844 | TANK | S230 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92854 | SEMA4D | S800 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q969X1 | TMBIM1 | S83 | ochoa | Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) | Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. |
| Q96C34 | RUNDC1 | S499 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96PD2 | DCBLD2 | S600 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96T58 | SPEN | S2156 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99614 | TTC1 | S69 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q99755 | PIP5K1A | S488 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}. |
| Q9BPX7 | C7orf25 | S212 | ochoa | UPF0415 protein C7orf25 | None |
| Q9BQE3 | TUBA1C | T56 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BSQ5 | CCM2 | S289 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BU76 | MMTAG2 | S125 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BVS4 | RIOK2 | S382 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BWT7 | CARD10 | S20 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
| Q9BXF6 | RAB11FIP5 | S566 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY77 | POLDIP3 | S217 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9C0D7 | ZC3H12C | S100 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9GZV4 | EIF5A2 | S46 | ochoa | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Q9H2Y7 | ZNF106 | S1304 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4I2 | ZHX3 | S899 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H4L7 | SMARCAD1 | S247 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9HBM0 | VEZT | S696 | ochoa | Vezatin | Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}. |
| Q9NVA2 | SEPTIN11 | S19 | ochoa | Septin-11 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}. |
| Q9NWW5 | CLN6 | S33 | ochoa | Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6) | None |
| Q9NZB2 | FAM120A | S1077 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P266 | JCAD | S1326 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2F8 | SIPA1L2 | S1554 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBL0 | ARPP21 | S397 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
| Q9ULL0 | KIAA1210 | S818 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9UP65 | PLA2G4C | S339 | ochoa | Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) | Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:15944408, PubMed:19501189). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:15944408, PubMed:19501189). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330, ECO:0000269|PubMed:9705332}.; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330). {ECO:0000269|PubMed:23015700, ECO:0000269|PubMed:28336330}.; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. {ECO:0000269|PubMed:28639618}. |
| Q9Y6D5 | ARFGEF2 | S279 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9C0C2 | TNKS1BP1 | S806 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P50416 | CPT1A | S612 | Sugiyama | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}. |
| O43615 | TIMM44 | S193 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| O15067 | PFAS | S227 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| P07900 | HSP90AA1 | S470 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| Q96RR4 | CAMKK2 | S28 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96JH7 | VCPIP1 | S1077 | Sugiyama | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.578371e-09 | 8.802 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.213671e-09 | 8.655 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.138653e-09 | 8.670 |
| R-HSA-9646399 | Aggrephagy | 1.318755e-08 | 7.880 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.042002e-08 | 7.517 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.993458e-08 | 7.222 |
| R-HSA-190861 | Gap junction assembly | 1.071232e-07 | 6.970 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.246394e-07 | 6.904 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.693567e-07 | 6.570 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.690970e-07 | 6.570 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.588819e-07 | 6.445 |
| R-HSA-190828 | Gap junction trafficking | 5.214652e-07 | 6.283 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.044946e-07 | 6.219 |
| R-HSA-9609690 | HCMV Early Events | 6.055760e-07 | 6.218 |
| R-HSA-157858 | Gap junction trafficking and regulation | 9.557352e-07 | 6.020 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.011779e-06 | 5.995 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.200441e-06 | 5.921 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.468682e-06 | 5.833 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.622589e-06 | 5.790 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.842549e-06 | 5.735 |
| R-HSA-9663891 | Selective autophagy | 2.993855e-06 | 5.524 |
| R-HSA-3371556 | Cellular response to heat stress | 3.973329e-06 | 5.401 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.798812e-06 | 5.420 |
| R-HSA-9612973 | Autophagy | 4.200962e-06 | 5.377 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.094106e-06 | 5.215 |
| R-HSA-9609646 | HCMV Infection | 6.160738e-06 | 5.210 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.935686e-06 | 5.227 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.136505e-05 | 4.944 |
| R-HSA-437239 | Recycling pathway of L1 | 1.136505e-05 | 4.944 |
| R-HSA-1632852 | Macroautophagy | 1.378967e-05 | 4.860 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.469087e-05 | 4.833 |
| R-HSA-69275 | G2/M Transition | 1.716221e-05 | 4.765 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.863099e-05 | 4.730 |
| R-HSA-68877 | Mitotic Prometaphase | 2.278438e-05 | 4.642 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.758096e-05 | 4.559 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.758096e-05 | 4.559 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.179760e-05 | 4.498 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.992044e-05 | 4.524 |
| R-HSA-983189 | Kinesins | 3.694401e-05 | 4.432 |
| R-HSA-391251 | Protein folding | 4.034517e-05 | 4.394 |
| R-HSA-68886 | M Phase | 6.992048e-05 | 4.155 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.622723e-05 | 4.118 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.622723e-05 | 4.118 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.352795e-05 | 4.078 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.388602e-05 | 4.076 |
| R-HSA-199991 | Membrane Trafficking | 1.011990e-04 | 3.995 |
| R-HSA-5617833 | Cilium Assembly | 1.169432e-04 | 3.932 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.268250e-04 | 3.897 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.438986e-04 | 3.842 |
| R-HSA-9833482 | PKR-mediated signaling | 1.501680e-04 | 3.823 |
| R-HSA-5620924 | Intraflagellar transport | 1.585956e-04 | 3.800 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.451110e-04 | 3.611 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.462022e-04 | 3.609 |
| R-HSA-1640170 | Cell Cycle | 2.773667e-04 | 3.557 |
| R-HSA-68882 | Mitotic Anaphase | 2.855426e-04 | 3.544 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.944223e-04 | 3.531 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.257227e-04 | 3.487 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.609713e-04 | 3.443 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.609713e-04 | 3.443 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.269085e-04 | 3.370 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.395235e-04 | 3.357 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.395235e-04 | 3.357 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.830518e-04 | 3.316 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.830518e-04 | 3.316 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5.027323e-04 | 3.299 |
| R-HSA-70171 | Glycolysis | 5.123631e-04 | 3.290 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.295659e-04 | 3.276 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.791798e-04 | 3.237 |
| R-HSA-3371511 | HSF1 activation | 6.320079e-04 | 3.199 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.881650e-04 | 3.162 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 6.928307e-04 | 3.159 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 6.928307e-04 | 3.159 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 6.928307e-04 | 3.159 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 8.109272e-04 | 3.091 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 8.415969e-04 | 3.075 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 7.477662e-04 | 3.126 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.109272e-04 | 3.091 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.690399e-04 | 3.061 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.896232e-04 | 3.103 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 8.777634e-04 | 3.057 |
| R-HSA-3371568 | Attenuation phase | 8.777634e-04 | 3.057 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 8.777634e-04 | 3.057 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 8.777634e-04 | 3.057 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 9.483907e-04 | 3.023 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.052560e-03 | 2.978 |
| R-HSA-373760 | L1CAM interactions | 1.153314e-03 | 2.938 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.182069e-03 | 2.927 |
| R-HSA-70326 | Glucose metabolism | 1.198935e-03 | 2.921 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.337748e-03 | 2.874 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.362445e-03 | 2.866 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.458249e-03 | 2.836 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.800810e-03 | 2.745 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.008545e-03 | 2.697 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.540275e-03 | 2.595 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.840622e-03 | 2.547 |
| R-HSA-191859 | snRNP Assembly | 3.163452e-03 | 2.500 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.163452e-03 | 2.500 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.232991e-03 | 2.490 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.294205e-03 | 2.482 |
| R-HSA-913531 | Interferon Signaling | 3.435278e-03 | 2.464 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.510457e-03 | 2.455 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.532337e-03 | 2.452 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.693289e-03 | 2.433 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 3.694164e-03 | 2.432 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.882480e-03 | 2.411 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.882480e-03 | 2.411 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.223342e-03 | 2.374 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.267212e-03 | 2.370 |
| R-HSA-211000 | Gene Silencing by RNA | 4.411112e-03 | 2.355 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.444109e-03 | 2.352 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.489227e-03 | 2.348 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 5.258317e-03 | 2.279 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.146214e-03 | 2.211 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.502970e-03 | 2.259 |
| R-HSA-392518 | Signal amplification | 6.041696e-03 | 2.219 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.411901e-03 | 2.193 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 6.135609e-03 | 2.212 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 5.258317e-03 | 2.279 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.887958e-03 | 2.230 |
| R-HSA-380287 | Centrosome maturation | 6.685106e-03 | 2.175 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.685106e-03 | 2.175 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 7.074822e-03 | 2.150 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.059867e-03 | 2.094 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.496561e-03 | 2.022 |
| R-HSA-2262752 | Cellular responses to stress | 1.105467e-02 | 1.956 |
| R-HSA-418457 | cGMP effects | 1.142815e-02 | 1.942 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.142815e-02 | 1.942 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.214745e-02 | 1.916 |
| R-HSA-112316 | Neuronal System | 1.234641e-02 | 1.908 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.266005e-02 | 1.898 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.286796e-02 | 1.890 |
| R-HSA-9824446 | Viral Infection Pathways | 1.348279e-02 | 1.870 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.528857e-02 | 1.816 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.557284e-02 | 1.808 |
| R-HSA-2028269 | Signaling by Hippo | 1.668308e-02 | 1.778 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.760496e-02 | 1.754 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.760496e-02 | 1.754 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.812972e-02 | 1.742 |
| R-HSA-392517 | Rap1 signalling | 1.962746e-02 | 1.707 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.967494e-02 | 1.706 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.984262e-02 | 1.702 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.065580e-02 | 1.685 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.490211e-02 | 1.457 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.490211e-02 | 1.457 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.490211e-02 | 1.457 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.490211e-02 | 1.457 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.490211e-02 | 1.457 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.490211e-02 | 1.457 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.490211e-02 | 1.457 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.490211e-02 | 1.457 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.490211e-02 | 1.457 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.490211e-02 | 1.457 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.490211e-02 | 1.457 |
| R-HSA-6798695 | Neutrophil degranulation | 2.748518e-02 | 1.561 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.333160e-02 | 1.477 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 2.629167e-02 | 1.580 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 2.629167e-02 | 1.580 |
| R-HSA-373755 | Semaphorin interactions | 2.591552e-02 | 1.586 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.795332e-02 | 1.554 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.528542e-02 | 1.597 |
| R-HSA-168255 | Influenza Infection | 3.251919e-02 | 1.488 |
| R-HSA-72306 | tRNA processing | 2.741737e-02 | 1.562 |
| R-HSA-68875 | Mitotic Prophase | 3.225932e-02 | 1.491 |
| R-HSA-109582 | Hemostasis | 2.758140e-02 | 1.559 |
| R-HSA-9679506 | SARS-CoV Infections | 3.342569e-02 | 1.476 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.533451e-02 | 1.452 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.612526e-02 | 1.442 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.854309e-02 | 1.414 |
| R-HSA-69481 | G2/M Checkpoints | 3.857427e-02 | 1.414 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.919810e-02 | 1.407 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.123461e-02 | 1.385 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.123461e-02 | 1.385 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.189709e-02 | 1.378 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.189709e-02 | 1.378 |
| R-HSA-8953854 | Metabolism of RNA | 4.190418e-02 | 1.378 |
| R-HSA-9675108 | Nervous system development | 4.334522e-02 | 1.363 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.489227e-02 | 1.348 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.070566e-02 | 1.295 |
| R-HSA-191650 | Regulation of gap junction activity | 5.189680e-02 | 1.285 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 5.189680e-02 | 1.285 |
| R-HSA-205025 | NADE modulates death signalling | 5.189680e-02 | 1.285 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.189680e-02 | 1.285 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.519354e-02 | 1.258 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 6.028237e-02 | 1.220 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.361390e-02 | 1.196 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 6.361390e-02 | 1.196 |
| R-HSA-422475 | Axon guidance | 6.630158e-02 | 1.178 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.770369e-02 | 1.169 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 6.859429e-02 | 1.164 |
| R-HSA-444821 | Relaxin receptors | 6.859429e-02 | 1.164 |
| R-HSA-9610379 | HCMV Late Events | 7.156255e-02 | 1.145 |
| R-HSA-162587 | HIV Life Cycle | 7.156255e-02 | 1.145 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.545882e-02 | 1.122 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 7.683319e-02 | 1.114 |
| R-HSA-1483152 | Hydrolysis of LPE | 7.683319e-02 | 1.114 |
| R-HSA-5619102 | SLC transporter disorders | 8.370684e-02 | 1.077 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 8.499973e-02 | 1.071 |
| R-HSA-162582 | Signal Transduction | 8.777942e-02 | 1.057 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.863941e-02 | 1.052 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.912026e-02 | 1.050 |
| R-HSA-70263 | Gluconeogenesis | 8.912026e-02 | 1.050 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.309452e-02 | 1.031 |
| R-HSA-196025 | Formation of annular gap junctions | 9.309452e-02 | 1.031 |
| R-HSA-190873 | Gap junction degradation | 1.011182e-01 | 0.995 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.247687e-01 | 0.904 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.247687e-01 | 0.904 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.325140e-01 | 0.878 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.775774e-01 | 0.751 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.775774e-01 | 0.751 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.377637e-01 | 0.861 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.529998e-01 | 0.815 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.247687e-01 | 0.904 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.702316e-01 | 0.769 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.011182e-01 | 0.995 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.011182e-01 | 0.995 |
| R-HSA-192905 | vRNP Assembly | 1.169547e-01 | 0.932 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.325140e-01 | 0.878 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.325140e-01 | 0.878 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.848586e-01 | 0.733 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.011182e-01 | 0.995 |
| R-HSA-196780 | Biotin transport and metabolism | 1.553441e-01 | 0.809 |
| R-HSA-1483115 | Hydrolysis of LPC | 1.478012e-01 | 0.830 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.848586e-01 | 0.733 |
| R-HSA-6809371 | Formation of the cornified envelope | 1.253479e-01 | 0.902 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.309452e-02 | 1.031 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.848586e-01 | 0.733 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.090714e-01 | 0.962 |
| R-HSA-416700 | Other semaphorin interactions | 1.553441e-01 | 0.809 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.702316e-01 | 0.769 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.011182e-01 | 0.995 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.628207e-01 | 0.788 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.113130e-01 | 0.953 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.553441e-01 | 0.809 |
| R-HSA-391908 | Prostanoid ligand receptors | 1.169547e-01 | 0.932 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.325140e-01 | 0.878 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.222805e-01 | 0.913 |
| R-HSA-597592 | Post-translational protein modification | 1.080060e-01 | 0.967 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.228971e-01 | 0.910 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.084644e-01 | 0.965 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.685460e-01 | 0.773 |
| R-HSA-162906 | HIV Infection | 1.781275e-01 | 0.749 |
| R-HSA-5663205 | Infectious disease | 1.833551e-01 | 0.737 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.560861e-01 | 0.807 |
| R-HSA-5357801 | Programmed Cell Death | 1.412511e-01 | 0.850 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.542860e-01 | 0.812 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.000416e-01 | 1.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.757613e-01 | 0.755 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.920757e-01 | 0.717 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.920757e-01 | 0.717 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.920757e-01 | 0.717 |
| R-HSA-73887 | Death Receptor Signaling | 1.974188e-01 | 0.705 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.992295e-01 | 0.701 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.992295e-01 | 0.701 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.992295e-01 | 0.701 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.992295e-01 | 0.701 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.992295e-01 | 0.701 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 1.992295e-01 | 0.701 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.992295e-01 | 0.701 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 1.992295e-01 | 0.701 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.035735e-01 | 0.691 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.035735e-01 | 0.691 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.063203e-01 | 0.685 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.063203e-01 | 0.685 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.063203e-01 | 0.685 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 2.068007e-01 | 0.684 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.133487e-01 | 0.671 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.141470e-01 | 0.669 |
| R-HSA-109581 | Apoptosis | 2.156556e-01 | 0.666 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.203154e-01 | 0.657 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.203154e-01 | 0.657 |
| R-HSA-200425 | Carnitine shuttle | 2.272207e-01 | 0.644 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.272207e-01 | 0.644 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.340654e-01 | 0.631 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.340654e-01 | 0.631 |
| R-HSA-429947 | Deadenylation of mRNA | 2.340654e-01 | 0.631 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.340654e-01 | 0.631 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.340654e-01 | 0.631 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.340654e-01 | 0.631 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.408498e-01 | 0.618 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.408498e-01 | 0.618 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.408498e-01 | 0.618 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.475746e-01 | 0.606 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.475746e-01 | 0.606 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.475746e-01 | 0.606 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.483528e-01 | 0.605 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.493529e-01 | 0.603 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.524134e-01 | 0.598 |
| R-HSA-201451 | Signaling by BMP | 2.542402e-01 | 0.595 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.542402e-01 | 0.595 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.542402e-01 | 0.595 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.556898e-01 | 0.592 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.589672e-01 | 0.587 |
| R-HSA-622312 | Inflammasomes | 2.608471e-01 | 0.584 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.655235e-01 | 0.576 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.673960e-01 | 0.573 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.673960e-01 | 0.573 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.673960e-01 | 0.573 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.720802e-01 | 0.565 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.738872e-01 | 0.562 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.738872e-01 | 0.562 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.738872e-01 | 0.562 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.738872e-01 | 0.562 |
| R-HSA-112311 | Neurotransmitter clearance | 2.738872e-01 | 0.562 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.803213e-01 | 0.552 |
| R-HSA-182971 | EGFR downregulation | 2.803213e-01 | 0.552 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.803213e-01 | 0.552 |
| R-HSA-418346 | Platelet homeostasis | 2.819116e-01 | 0.550 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.930201e-01 | 0.533 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.930201e-01 | 0.533 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.930201e-01 | 0.533 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.930201e-01 | 0.533 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.930201e-01 | 0.533 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.937886e-01 | 0.532 |
| R-HSA-390522 | Striated Muscle Contraction | 2.992858e-01 | 0.524 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.992858e-01 | 0.524 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.992858e-01 | 0.524 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 2.992858e-01 | 0.524 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.992858e-01 | 0.524 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.054964e-01 | 0.515 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.054964e-01 | 0.515 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.054964e-01 | 0.515 |
| R-HSA-203615 | eNOS activation | 3.054964e-01 | 0.515 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.113202e-01 | 0.507 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.116523e-01 | 0.506 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.116523e-01 | 0.506 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.116523e-01 | 0.506 |
| R-HSA-74160 | Gene expression (Transcription) | 3.123077e-01 | 0.505 |
| R-HSA-111933 | Calmodulin induced events | 3.177541e-01 | 0.498 |
| R-HSA-111997 | CaM pathway | 3.177541e-01 | 0.498 |
| R-HSA-72172 | mRNA Splicing | 3.203739e-01 | 0.494 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.238021e-01 | 0.490 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.238021e-01 | 0.490 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.238021e-01 | 0.490 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.243194e-01 | 0.489 |
| R-HSA-6805567 | Keratinization | 3.252150e-01 | 0.488 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 3.297968e-01 | 0.482 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.297968e-01 | 0.482 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.297968e-01 | 0.482 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.297968e-01 | 0.482 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.416285e-01 | 0.466 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 3.416285e-01 | 0.466 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.474663e-01 | 0.459 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.474663e-01 | 0.459 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.474663e-01 | 0.459 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.474663e-01 | 0.459 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.532527e-01 | 0.452 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.532527e-01 | 0.452 |
| R-HSA-165159 | MTOR signalling | 3.589882e-01 | 0.445 |
| R-HSA-111996 | Ca-dependent events | 3.589882e-01 | 0.445 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.589882e-01 | 0.445 |
| R-HSA-8854214 | TBC/RABGAPs | 3.646731e-01 | 0.438 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.703080e-01 | 0.431 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.758933e-01 | 0.425 |
| R-HSA-9909396 | Circadian clock | 3.787424e-01 | 0.422 |
| R-HSA-9675135 | Diseases of DNA repair | 3.814293e-01 | 0.419 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.814293e-01 | 0.419 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.814293e-01 | 0.419 |
| R-HSA-1266738 | Developmental Biology | 3.854728e-01 | 0.414 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.869166e-01 | 0.412 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.944206e-01 | 0.404 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.975352e-01 | 0.401 |
| R-HSA-9766229 | Degradation of CDH1 | 3.977466e-01 | 0.400 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.030901e-01 | 0.395 |
| R-HSA-157118 | Signaling by NOTCH | 4.069797e-01 | 0.390 |
| R-HSA-912446 | Meiotic recombination | 4.083866e-01 | 0.389 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.099193e-01 | 0.387 |
| R-HSA-72187 | mRNA 3'-end processing | 4.136363e-01 | 0.383 |
| R-HSA-1221632 | Meiotic synapsis | 4.188398e-01 | 0.378 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.188398e-01 | 0.378 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.188398e-01 | 0.378 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.191265e-01 | 0.378 |
| R-HSA-177929 | Signaling by EGFR | 4.341769e-01 | 0.362 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.391993e-01 | 0.357 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.403238e-01 | 0.356 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.403238e-01 | 0.356 |
| R-HSA-5688426 | Deubiquitination | 4.422348e-01 | 0.354 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.491119e-01 | 0.348 |
| R-HSA-186712 | Regulation of beta-cell development | 4.491119e-01 | 0.348 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.491119e-01 | 0.348 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.492798e-01 | 0.347 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.540027e-01 | 0.343 |
| R-HSA-1989781 | PPARA activates gene expression | 4.552061e-01 | 0.342 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.588504e-01 | 0.338 |
| R-HSA-112043 | PLC beta mediated events | 4.588504e-01 | 0.338 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.610960e-01 | 0.336 |
| R-HSA-1268020 | Mitochondrial protein import | 4.636554e-01 | 0.334 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.636554e-01 | 0.334 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.731385e-01 | 0.325 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.870520e-01 | 0.312 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.870520e-01 | 0.312 |
| R-HSA-112040 | G-protein mediated events | 4.870520e-01 | 0.312 |
| R-HSA-5218859 | Regulated Necrosis | 4.916083e-01 | 0.308 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.006005e-01 | 0.301 |
| R-HSA-8978934 | Metabolism of cofactors | 5.050373e-01 | 0.297 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.094349e-01 | 0.293 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.123893e-01 | 0.290 |
| R-HSA-4086398 | Ca2+ pathway | 5.137936e-01 | 0.289 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.181140e-01 | 0.286 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.187686e-01 | 0.285 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.223962e-01 | 0.282 |
| R-HSA-8852135 | Protein ubiquitination | 5.223962e-01 | 0.282 |
| R-HSA-1483257 | Phospholipid metabolism | 5.317832e-01 | 0.274 |
| R-HSA-6806834 | Signaling by MET | 5.432469e-01 | 0.265 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.473073e-01 | 0.262 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.604030e-01 | 0.251 |
| R-HSA-1500620 | Meiosis | 5.631935e-01 | 0.249 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.631935e-01 | 0.249 |
| R-HSA-1643685 | Disease | 5.642833e-01 | 0.249 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.670778e-01 | 0.246 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.709278e-01 | 0.243 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.785260e-01 | 0.238 |
| R-HSA-428157 | Sphingolipid metabolism | 5.831263e-01 | 0.234 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.859906e-01 | 0.232 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 5.880581e-01 | 0.231 |
| R-HSA-392499 | Metabolism of proteins | 5.894700e-01 | 0.230 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.896735e-01 | 0.229 |
| R-HSA-168256 | Immune System | 6.045883e-01 | 0.219 |
| R-HSA-1280218 | Adaptive Immune System | 6.114196e-01 | 0.214 |
| R-HSA-397014 | Muscle contraction | 6.120726e-01 | 0.213 |
| R-HSA-418990 | Adherens junctions interactions | 6.259658e-01 | 0.203 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.260190e-01 | 0.203 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.314107e-01 | 0.200 |
| R-HSA-1483255 | PI Metabolism | 6.346922e-01 | 0.197 |
| R-HSA-111885 | Opioid Signalling | 6.411685e-01 | 0.193 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.475307e-01 | 0.189 |
| R-HSA-212436 | Generic Transcription Pathway | 6.485626e-01 | 0.188 |
| R-HSA-72312 | rRNA processing | 6.568897e-01 | 0.183 |
| R-HSA-168249 | Innate Immune System | 6.607695e-01 | 0.180 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.629505e-01 | 0.179 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.629505e-01 | 0.179 |
| R-HSA-6803157 | Antimicrobial peptides | 6.659531e-01 | 0.177 |
| R-HSA-8939211 | ESR-mediated signaling | 6.674323e-01 | 0.176 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.701501e-01 | 0.174 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.748025e-01 | 0.171 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.748025e-01 | 0.171 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.834190e-01 | 0.165 |
| R-HSA-5693538 | Homology Directed Repair | 6.918088e-01 | 0.160 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.918088e-01 | 0.160 |
| R-HSA-421270 | Cell-cell junction organization | 6.955732e-01 | 0.158 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.053038e-01 | 0.152 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.053038e-01 | 0.152 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.096661e-01 | 0.149 |
| R-HSA-194138 | Signaling by VEGF | 7.131175e-01 | 0.147 |
| R-HSA-388396 | GPCR downstream signalling | 7.134233e-01 | 0.147 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 7.158223e-01 | 0.145 |
| R-HSA-114608 | Platelet degranulation | 7.182120e-01 | 0.144 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.256857e-01 | 0.139 |
| R-HSA-1474165 | Reproduction | 7.281329e-01 | 0.138 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.353453e-01 | 0.134 |
| R-HSA-446728 | Cell junction organization | 7.443171e-01 | 0.128 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.446670e-01 | 0.128 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.714830e-01 | 0.113 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.727685e-01 | 0.112 |
| R-HSA-195721 | Signaling by WNT | 7.760094e-01 | 0.110 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.768102e-01 | 0.110 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.788042e-01 | 0.109 |
| R-HSA-9609507 | Protein localization | 7.827393e-01 | 0.106 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.959725e-01 | 0.099 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.959725e-01 | 0.099 |
| R-HSA-372790 | Signaling by GPCR | 7.971531e-01 | 0.098 |
| R-HSA-1500931 | Cell-Cell communication | 8.015647e-01 | 0.096 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.107891e-01 | 0.091 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.151684e-01 | 0.089 |
| R-HSA-418555 | G alpha (s) signalling events | 8.168219e-01 | 0.088 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.200849e-01 | 0.086 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.200849e-01 | 0.086 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.200849e-01 | 0.086 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.355540e-01 | 0.078 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.395948e-01 | 0.076 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.399318e-01 | 0.076 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.427858e-01 | 0.074 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.469723e-01 | 0.072 |
| R-HSA-73894 | DNA Repair | 8.534971e-01 | 0.069 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.537053e-01 | 0.069 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.565466e-01 | 0.067 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.575502e-01 | 0.067 |
| R-HSA-8951664 | Neddylation | 8.842516e-01 | 0.053 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.932747e-01 | 0.049 |
| R-HSA-418594 | G alpha (i) signalling events | 8.958622e-01 | 0.048 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.970573e-01 | 0.047 |
| R-HSA-15869 | Metabolism of nucleotides | 8.988984e-01 | 0.046 |
| R-HSA-4839726 | Chromatin organization | 9.100937e-01 | 0.041 |
| R-HSA-500792 | GPCR ligand binding | 9.105945e-01 | 0.041 |
| R-HSA-416476 | G alpha (q) signalling events | 9.214892e-01 | 0.036 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.242777e-01 | 0.034 |
| R-HSA-449147 | Signaling by Interleukins | 9.291866e-01 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.308261e-01 | 0.031 |
| R-HSA-9658195 | Leishmania infection | 9.326786e-01 | 0.030 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.326786e-01 | 0.030 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.373813e-01 | 0.028 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.412277e-01 | 0.026 |
| R-HSA-1474244 | Extracellular matrix organization | 9.572108e-01 | 0.019 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.767397e-01 | 0.010 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.780311e-01 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 9.787672e-01 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 9.823104e-01 | 0.008 |
| R-HSA-556833 | Metabolism of lipids | 9.836500e-01 | 0.007 |
| R-HSA-211859 | Biological oxidations | 9.926598e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.998347e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.998976e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MOS |
0.807 | 0.372 | 1 | 0.814 |
GRK1 |
0.806 | 0.337 | -2 | 0.577 |
COT |
0.804 | 0.137 | 2 | 0.831 |
BMPR1B |
0.802 | 0.249 | 1 | 0.710 |
KIS |
0.798 | 0.175 | 1 | 0.565 |
CDC7 |
0.795 | 0.161 | 1 | 0.795 |
DSTYK |
0.795 | 0.133 | 2 | 0.861 |
PIM3 |
0.794 | 0.074 | -3 | 0.747 |
CLK3 |
0.790 | 0.068 | 1 | 0.739 |
GRK7 |
0.789 | 0.251 | 1 | 0.623 |
BMPR1A |
0.788 | 0.205 | 1 | 0.717 |
ALK2 |
0.787 | 0.220 | -2 | 0.477 |
PRPK |
0.787 | 0.010 | -1 | 0.799 |
FAM20C |
0.786 | 0.099 | 2 | 0.630 |
IKKB |
0.786 | -0.015 | -2 | 0.354 |
TGFBR1 |
0.786 | 0.124 | -2 | 0.452 |
GRK4 |
0.786 | 0.194 | -2 | 0.535 |
GCN2 |
0.786 | -0.006 | 2 | 0.777 |
CAMK2G |
0.783 | 0.030 | 2 | 0.824 |
NDR2 |
0.782 | 0.018 | -3 | 0.747 |
IKKA |
0.781 | 0.031 | -2 | 0.359 |
BMPR2 |
0.781 | 0.004 | -2 | 0.413 |
ACVR2B |
0.781 | 0.122 | -2 | 0.432 |
GRK5 |
0.781 | 0.066 | -3 | 0.836 |
CK2A2 |
0.780 | 0.215 | 1 | 0.661 |
ATR |
0.779 | -0.026 | 1 | 0.674 |
TGFBR2 |
0.779 | -0.003 | -2 | 0.444 |
GRK6 |
0.778 | 0.096 | 1 | 0.679 |
ALK4 |
0.776 | 0.080 | -2 | 0.445 |
ACVR2A |
0.775 | 0.071 | -2 | 0.417 |
MTOR |
0.775 | -0.080 | 1 | 0.594 |
PIM1 |
0.775 | 0.029 | -3 | 0.671 |
NEK6 |
0.775 | -0.045 | -2 | 0.400 |
ATM |
0.774 | 0.038 | 1 | 0.630 |
RAF1 |
0.774 | -0.076 | 1 | 0.660 |
ERK5 |
0.774 | -0.017 | 1 | 0.668 |
MLK1 |
0.773 | -0.023 | 2 | 0.767 |
CAMK1B |
0.772 | -0.075 | -3 | 0.780 |
TTBK2 |
0.772 | 0.089 | 2 | 0.690 |
PDHK4 |
0.772 | -0.204 | 1 | 0.669 |
TBK1 |
0.771 | -0.109 | 1 | 0.528 |
NEK7 |
0.771 | -0.087 | -3 | 0.807 |
NLK |
0.770 | -0.044 | 1 | 0.653 |
HUNK |
0.770 | -0.003 | 2 | 0.785 |
IKKE |
0.770 | -0.108 | 1 | 0.518 |
NDR1 |
0.770 | -0.036 | -3 | 0.734 |
CDKL1 |
0.769 | -0.042 | -3 | 0.720 |
GRK2 |
0.769 | 0.060 | -2 | 0.456 |
SKMLCK |
0.769 | -0.045 | -2 | 0.399 |
MARK4 |
0.769 | -0.051 | 4 | 0.828 |
GRK3 |
0.768 | 0.101 | -2 | 0.489 |
CK2A1 |
0.768 | 0.179 | 1 | 0.624 |
ULK2 |
0.767 | -0.170 | 2 | 0.744 |
CAMLCK |
0.766 | -0.074 | -2 | 0.361 |
PKN3 |
0.765 | -0.064 | -3 | 0.742 |
NIK |
0.765 | -0.122 | -3 | 0.806 |
CK1E |
0.765 | 0.139 | -3 | 0.520 |
RSK2 |
0.765 | -0.028 | -3 | 0.666 |
HIPK4 |
0.764 | -0.050 | 1 | 0.652 |
PDHK1 |
0.764 | -0.237 | 1 | 0.653 |
CHAK2 |
0.764 | -0.075 | -1 | 0.724 |
DAPK2 |
0.763 | -0.089 | -3 | 0.785 |
RIPK3 |
0.763 | -0.071 | 3 | 0.674 |
SRPK1 |
0.762 | -0.033 | -3 | 0.660 |
MLK3 |
0.762 | -0.019 | 2 | 0.702 |
TLK1 |
0.762 | 0.058 | -2 | 0.475 |
CAMK2B |
0.762 | -0.005 | 2 | 0.809 |
MASTL |
0.762 | -0.162 | -2 | 0.376 |
PLK3 |
0.762 | -0.017 | 2 | 0.769 |
LATS2 |
0.762 | -0.045 | -5 | 0.712 |
NUAK2 |
0.762 | -0.071 | -3 | 0.735 |
P70S6KB |
0.761 | -0.028 | -3 | 0.690 |
AURC |
0.761 | -0.043 | -2 | 0.275 |
CDK8 |
0.761 | -0.041 | 1 | 0.524 |
CDKL5 |
0.761 | -0.056 | -3 | 0.701 |
PKACG |
0.761 | -0.062 | -2 | 0.323 |
MLK2 |
0.761 | -0.109 | 2 | 0.783 |
TLK2 |
0.761 | -0.038 | 1 | 0.614 |
PLK1 |
0.760 | -0.082 | -2 | 0.386 |
CK1D |
0.759 | 0.141 | -3 | 0.474 |
ANKRD3 |
0.759 | -0.112 | 1 | 0.671 |
MPSK1 |
0.759 | 0.146 | 1 | 0.743 |
JNK3 |
0.759 | 0.013 | 1 | 0.516 |
RSK4 |
0.759 | 0.008 | -3 | 0.637 |
BCKDK |
0.759 | -0.131 | -1 | 0.716 |
MST4 |
0.758 | -0.067 | 2 | 0.772 |
WNK1 |
0.758 | -0.111 | -2 | 0.376 |
AMPKA1 |
0.758 | -0.072 | -3 | 0.741 |
LATS1 |
0.758 | -0.022 | -3 | 0.780 |
RSK3 |
0.758 | -0.053 | -3 | 0.668 |
PKR |
0.758 | -0.044 | 1 | 0.711 |
AURA |
0.757 | -0.040 | -2 | 0.284 |
PKACB |
0.757 | -0.035 | -2 | 0.281 |
GAK |
0.757 | 0.185 | 1 | 0.784 |
SMG1 |
0.757 | -0.036 | 1 | 0.633 |
MLK4 |
0.757 | -0.029 | 2 | 0.698 |
PERK |
0.757 | -0.003 | -2 | 0.442 |
DLK |
0.757 | -0.139 | 1 | 0.625 |
PRKD1 |
0.756 | -0.098 | -3 | 0.701 |
CDK1 |
0.756 | -0.003 | 1 | 0.492 |
SRPK3 |
0.756 | -0.021 | -3 | 0.646 |
ICK |
0.756 | -0.086 | -3 | 0.751 |
DYRK2 |
0.756 | -0.038 | 1 | 0.550 |
NEK9 |
0.755 | -0.180 | 2 | 0.785 |
WNK3 |
0.755 | -0.181 | 1 | 0.643 |
PKN2 |
0.755 | -0.089 | -3 | 0.734 |
YSK4 |
0.755 | -0.097 | 1 | 0.573 |
P90RSK |
0.755 | -0.068 | -3 | 0.675 |
MEK1 |
0.755 | -0.109 | 2 | 0.811 |
ULK1 |
0.755 | -0.171 | -3 | 0.794 |
CAMK2D |
0.755 | -0.117 | -3 | 0.738 |
JNK2 |
0.755 | 0.006 | 1 | 0.470 |
PIM2 |
0.754 | 0.012 | -3 | 0.634 |
CAMK2A |
0.754 | -0.025 | 2 | 0.830 |
MEKK3 |
0.754 | 0.044 | 1 | 0.586 |
PRKX |
0.754 | -0.016 | -3 | 0.555 |
PKCD |
0.754 | -0.084 | 2 | 0.739 |
SRPK2 |
0.754 | -0.034 | -3 | 0.576 |
AURB |
0.753 | -0.059 | -2 | 0.273 |
CDK19 |
0.753 | -0.045 | 1 | 0.491 |
TSSK2 |
0.753 | -0.119 | -5 | 0.707 |
PAK1 |
0.753 | -0.074 | -2 | 0.322 |
IRE1 |
0.753 | -0.091 | 1 | 0.680 |
PRP4 |
0.752 | 0.007 | -3 | 0.741 |
PINK1 |
0.752 | -0.084 | 1 | 0.734 |
DNAPK |
0.752 | -0.023 | 1 | 0.511 |
P38A |
0.752 | -0.034 | 1 | 0.568 |
RIPK1 |
0.752 | -0.129 | 1 | 0.647 |
PRKD2 |
0.752 | -0.085 | -3 | 0.638 |
QSK |
0.751 | -0.062 | 4 | 0.817 |
MAPKAPK2 |
0.751 | -0.050 | -3 | 0.605 |
P38B |
0.751 | -0.022 | 1 | 0.498 |
ERK1 |
0.751 | -0.021 | 1 | 0.491 |
P38G |
0.750 | -0.010 | 1 | 0.415 |
CLK2 |
0.750 | 0.002 | -3 | 0.645 |
CDK5 |
0.750 | -0.024 | 1 | 0.574 |
VRK2 |
0.750 | -0.209 | 1 | 0.709 |
AMPKA2 |
0.750 | -0.082 | -3 | 0.700 |
NIM1 |
0.749 | -0.127 | 3 | 0.728 |
MSK2 |
0.749 | -0.084 | -3 | 0.637 |
MYLK4 |
0.749 | -0.064 | -2 | 0.348 |
BRAF |
0.749 | -0.029 | -4 | 0.831 |
CDK18 |
0.748 | -0.026 | 1 | 0.496 |
PASK |
0.748 | 0.027 | -3 | 0.773 |
MEKK2 |
0.748 | -0.023 | 2 | 0.769 |
MARK2 |
0.748 | -0.062 | 4 | 0.747 |
HIPK2 |
0.748 | -0.011 | 1 | 0.489 |
IRE2 |
0.748 | -0.086 | 2 | 0.674 |
HIPK1 |
0.748 | -0.014 | 1 | 0.577 |
MARK3 |
0.748 | -0.054 | 4 | 0.775 |
PAK3 |
0.748 | -0.113 | -2 | 0.308 |
MSK1 |
0.747 | -0.060 | -3 | 0.638 |
QIK |
0.747 | -0.129 | -3 | 0.736 |
CAMK4 |
0.747 | -0.136 | -3 | 0.709 |
MAPKAPK3 |
0.747 | -0.118 | -3 | 0.647 |
PAK2 |
0.747 | -0.095 | -2 | 0.319 |
PLK2 |
0.746 | 0.030 | -3 | 0.831 |
PKCB |
0.745 | -0.072 | 2 | 0.695 |
P38D |
0.745 | -0.019 | 1 | 0.470 |
TSSK1 |
0.745 | -0.124 | -3 | 0.758 |
DYRK4 |
0.745 | -0.019 | 1 | 0.493 |
HRI |
0.745 | -0.123 | -2 | 0.399 |
CK1A2 |
0.745 | 0.072 | -3 | 0.465 |
CDK7 |
0.744 | -0.063 | 1 | 0.550 |
PKG2 |
0.744 | -0.082 | -2 | 0.267 |
SIK |
0.744 | -0.084 | -3 | 0.645 |
PKCA |
0.744 | -0.080 | 2 | 0.673 |
PKCG |
0.744 | -0.085 | 2 | 0.689 |
CLK4 |
0.744 | -0.065 | -3 | 0.659 |
ERK2 |
0.743 | -0.038 | 1 | 0.524 |
CDK17 |
0.743 | -0.029 | 1 | 0.431 |
PAK6 |
0.743 | -0.050 | -2 | 0.248 |
MEK5 |
0.743 | -0.138 | 2 | 0.789 |
AKT2 |
0.743 | -0.048 | -3 | 0.574 |
CHAK1 |
0.743 | -0.145 | 2 | 0.725 |
DRAK1 |
0.743 | -0.090 | 1 | 0.557 |
MEKK1 |
0.742 | -0.118 | 1 | 0.620 |
SGK3 |
0.742 | -0.060 | -3 | 0.646 |
CK1G1 |
0.742 | 0.040 | -3 | 0.558 |
PKCZ |
0.742 | -0.112 | 2 | 0.726 |
NEK5 |
0.741 | -0.124 | 1 | 0.677 |
ZAK |
0.741 | -0.105 | 1 | 0.567 |
MARK1 |
0.741 | -0.085 | 4 | 0.788 |
TTBK1 |
0.741 | -0.029 | 2 | 0.610 |
CAMKK1 |
0.741 | -0.110 | -2 | 0.322 |
CDK13 |
0.741 | -0.073 | 1 | 0.524 |
GSK3A |
0.741 | 0.001 | 4 | 0.370 |
CDK2 |
0.740 | -0.060 | 1 | 0.547 |
JNK1 |
0.740 | 0.005 | 1 | 0.471 |
NEK2 |
0.740 | -0.177 | 2 | 0.756 |
BRSK1 |
0.740 | -0.095 | -3 | 0.680 |
PKACA |
0.740 | -0.058 | -2 | 0.246 |
PLK4 |
0.740 | -0.118 | 2 | 0.595 |
NUAK1 |
0.739 | -0.127 | -3 | 0.683 |
PRKD3 |
0.739 | -0.103 | -3 | 0.628 |
MST3 |
0.739 | -0.039 | 2 | 0.778 |
PKCH |
0.739 | -0.105 | 2 | 0.673 |
CDK3 |
0.739 | -0.023 | 1 | 0.458 |
CDK16 |
0.738 | -0.019 | 1 | 0.460 |
MELK |
0.738 | -0.142 | -3 | 0.679 |
DYRK1B |
0.738 | -0.037 | 1 | 0.521 |
DAPK3 |
0.738 | -0.036 | -3 | 0.692 |
CAMK1G |
0.738 | -0.087 | -3 | 0.653 |
TAO3 |
0.737 | -0.071 | 1 | 0.598 |
CHK1 |
0.737 | -0.145 | -3 | 0.714 |
TAK1 |
0.735 | 0.015 | 1 | 0.643 |
MST2 |
0.735 | -0.055 | 1 | 0.596 |
MNK2 |
0.735 | -0.142 | -2 | 0.303 |
HIPK3 |
0.735 | -0.061 | 1 | 0.555 |
DYRK1A |
0.734 | -0.071 | 1 | 0.594 |
ALPHAK3 |
0.734 | 0.164 | -1 | 0.729 |
CLK1 |
0.734 | -0.079 | -3 | 0.633 |
LKB1 |
0.734 | -0.079 | -3 | 0.777 |
NEK8 |
0.734 | -0.116 | 2 | 0.761 |
SMMLCK |
0.734 | -0.103 | -3 | 0.727 |
DYRK3 |
0.734 | -0.057 | 1 | 0.571 |
SNRK |
0.733 | -0.174 | 2 | 0.645 |
EEF2K |
0.733 | -0.034 | 3 | 0.731 |
PHKG1 |
0.733 | -0.148 | -3 | 0.710 |
CDK14 |
0.732 | -0.045 | 1 | 0.521 |
MNK1 |
0.732 | -0.128 | -2 | 0.318 |
IRAK4 |
0.732 | -0.141 | 1 | 0.680 |
DAPK1 |
0.732 | -0.044 | -3 | 0.677 |
BRSK2 |
0.732 | -0.140 | -3 | 0.701 |
CDK12 |
0.732 | -0.076 | 1 | 0.488 |
CAMKK2 |
0.731 | -0.143 | -2 | 0.300 |
DCAMKL1 |
0.731 | -0.128 | -3 | 0.659 |
TTK |
0.731 | 0.031 | -2 | 0.444 |
CDK9 |
0.731 | -0.086 | 1 | 0.526 |
P70S6K |
0.730 | -0.049 | -3 | 0.593 |
PBK |
0.730 | 0.052 | 1 | 0.753 |
GSK3B |
0.730 | -0.044 | 4 | 0.362 |
ERK7 |
0.730 | -0.030 | 2 | 0.500 |
WNK4 |
0.730 | -0.171 | -2 | 0.359 |
AKT1 |
0.729 | -0.067 | -3 | 0.583 |
SSTK |
0.729 | -0.108 | 4 | 0.804 |
GCK |
0.729 | -0.056 | 1 | 0.572 |
NEK11 |
0.728 | -0.119 | 1 | 0.572 |
TAO2 |
0.728 | -0.130 | 2 | 0.791 |
PDK1 |
0.727 | -0.122 | 1 | 0.634 |
PAK5 |
0.727 | -0.085 | -2 | 0.240 |
CDK10 |
0.725 | -0.037 | 1 | 0.514 |
CAMK1D |
0.725 | -0.091 | -3 | 0.565 |
TNIK |
0.725 | -0.082 | 3 | 0.749 |
MAK |
0.724 | -0.039 | -2 | 0.273 |
PKCT |
0.724 | -0.124 | 2 | 0.682 |
MAPKAPK5 |
0.723 | -0.170 | -3 | 0.604 |
VRK1 |
0.723 | -0.133 | 2 | 0.774 |
MINK |
0.723 | -0.101 | 1 | 0.585 |
IRAK1 |
0.723 | -0.195 | -1 | 0.652 |
ROCK2 |
0.722 | -0.049 | -3 | 0.669 |
SGK1 |
0.722 | -0.040 | -3 | 0.492 |
BIKE |
0.722 | 0.077 | 1 | 0.739 |
PAK4 |
0.722 | -0.075 | -2 | 0.249 |
LRRK2 |
0.721 | -0.159 | 2 | 0.790 |
MRCKB |
0.721 | -0.061 | -3 | 0.623 |
MST1 |
0.721 | -0.104 | 1 | 0.578 |
AKT3 |
0.720 | -0.053 | -3 | 0.504 |
OSR1 |
0.720 | -0.036 | 2 | 0.749 |
NEK4 |
0.720 | -0.187 | 1 | 0.609 |
MAP3K15 |
0.720 | -0.135 | 1 | 0.560 |
CK1A |
0.719 | 0.089 | -3 | 0.396 |
HPK1 |
0.719 | -0.090 | 1 | 0.550 |
DMPK1 |
0.719 | -0.031 | -3 | 0.646 |
MRCKA |
0.719 | -0.065 | -3 | 0.643 |
MEKK6 |
0.719 | -0.152 | 1 | 0.599 |
HGK |
0.718 | -0.145 | 3 | 0.749 |
DCAMKL2 |
0.718 | -0.151 | -3 | 0.691 |
PKCE |
0.717 | -0.089 | 2 | 0.665 |
CDK6 |
0.717 | -0.060 | 1 | 0.515 |
NEK1 |
0.717 | -0.184 | 1 | 0.644 |
PKCI |
0.716 | -0.138 | 2 | 0.684 |
MEK2 |
0.716 | -0.197 | 2 | 0.774 |
SLK |
0.716 | -0.134 | -2 | 0.311 |
MOK |
0.715 | -0.053 | 1 | 0.610 |
LOK |
0.715 | -0.155 | -2 | 0.299 |
KHS1 |
0.712 | -0.115 | 1 | 0.565 |
KHS2 |
0.711 | -0.080 | 1 | 0.566 |
STK33 |
0.711 | -0.150 | 2 | 0.589 |
PHKG2 |
0.711 | -0.186 | -3 | 0.683 |
YSK1 |
0.710 | -0.146 | 2 | 0.752 |
BUB1 |
0.709 | -0.081 | -5 | 0.678 |
ROCK1 |
0.709 | -0.065 | -3 | 0.631 |
CDK4 |
0.708 | -0.076 | 1 | 0.483 |
PDHK3_TYR |
0.708 | 0.078 | 4 | 0.838 |
CAMK1A |
0.708 | -0.103 | -3 | 0.536 |
PDHK1_TYR |
0.707 | 0.140 | -1 | 0.848 |
MAP2K6_TYR |
0.707 | 0.107 | -1 | 0.826 |
PDHK4_TYR |
0.707 | 0.107 | 2 | 0.851 |
AAK1 |
0.707 | 0.088 | 1 | 0.680 |
PKG1 |
0.706 | -0.110 | -2 | 0.210 |
CRIK |
0.706 | -0.023 | -3 | 0.586 |
SBK |
0.705 | -0.076 | -3 | 0.446 |
CK1G2 |
0.705 | 0.124 | -3 | 0.462 |
HASPIN |
0.705 | -0.047 | -1 | 0.546 |
CHK2 |
0.704 | -0.108 | -3 | 0.509 |
BLK |
0.704 | 0.203 | -1 | 0.823 |
MAP2K4_TYR |
0.704 | 0.049 | -1 | 0.818 |
PKN1 |
0.704 | -0.129 | -3 | 0.602 |
MYO3B |
0.703 | -0.115 | 2 | 0.757 |
BMPR2_TYR |
0.703 | 0.071 | -1 | 0.820 |
RIPK2 |
0.703 | -0.233 | 1 | 0.535 |
MYO3A |
0.702 | -0.110 | 1 | 0.593 |
TXK |
0.702 | 0.146 | 1 | 0.692 |
YANK3 |
0.702 | -0.045 | 2 | 0.392 |
CK1G3 |
0.701 | 0.061 | -3 | 0.358 |
ASK1 |
0.700 | -0.157 | 1 | 0.556 |
EPHA6 |
0.700 | 0.100 | -1 | 0.825 |
LCK |
0.699 | 0.165 | -1 | 0.812 |
NEK3 |
0.699 | -0.218 | 1 | 0.582 |
TESK1_TYR |
0.698 | -0.045 | 3 | 0.823 |
FGR |
0.698 | 0.097 | 1 | 0.709 |
FYN |
0.697 | 0.177 | -1 | 0.791 |
MAP2K7_TYR |
0.697 | -0.098 | 2 | 0.831 |
STLK3 |
0.697 | -0.126 | 1 | 0.534 |
YES1 |
0.696 | 0.082 | -1 | 0.806 |
EPHB4 |
0.695 | 0.057 | -1 | 0.816 |
PKMYT1_TYR |
0.695 | -0.046 | 3 | 0.789 |
FER |
0.693 | 0.066 | 1 | 0.749 |
SYK |
0.693 | 0.231 | -1 | 0.775 |
EPHA4 |
0.692 | 0.085 | 2 | 0.761 |
HCK |
0.691 | 0.081 | -1 | 0.807 |
PINK1_TYR |
0.691 | -0.124 | 1 | 0.692 |
EPHB2 |
0.691 | 0.095 | -1 | 0.808 |
ABL2 |
0.691 | 0.025 | -1 | 0.777 |
SRMS |
0.690 | 0.075 | 1 | 0.708 |
EPHB3 |
0.687 | 0.041 | -1 | 0.810 |
TAO1 |
0.686 | -0.187 | 1 | 0.525 |
ABL1 |
0.685 | 0.001 | -1 | 0.764 |
LIMK2_TYR |
0.685 | -0.123 | -3 | 0.813 |
RET |
0.685 | -0.136 | 1 | 0.617 |
INSRR |
0.684 | -0.011 | 3 | 0.683 |
ITK |
0.684 | 0.017 | -1 | 0.766 |
SRC |
0.683 | 0.104 | -1 | 0.785 |
EPHB1 |
0.683 | 0.005 | 1 | 0.678 |
LYN |
0.682 | 0.074 | 3 | 0.640 |
MET |
0.682 | 0.046 | 3 | 0.715 |
LIMK1_TYR |
0.682 | -0.174 | 2 | 0.806 |
TYRO3 |
0.681 | -0.094 | 3 | 0.713 |
MST1R |
0.681 | -0.111 | 3 | 0.734 |
JAK3 |
0.680 | -0.069 | 1 | 0.601 |
YANK2 |
0.680 | -0.045 | 2 | 0.411 |
CSF1R |
0.679 | -0.085 | 3 | 0.707 |
TYK2 |
0.679 | -0.199 | 1 | 0.625 |
FLT1 |
0.679 | 0.006 | -1 | 0.801 |
EPHA5 |
0.679 | 0.069 | 2 | 0.757 |
BMX |
0.678 | 0.023 | -1 | 0.717 |
ROS1 |
0.678 | -0.116 | 3 | 0.687 |
TEC |
0.678 | 0.035 | -1 | 0.708 |
EPHA7 |
0.677 | 0.022 | 2 | 0.757 |
FRK |
0.677 | 0.053 | -1 | 0.836 |
KDR |
0.677 | -0.056 | 3 | 0.683 |
KIT |
0.677 | -0.059 | 3 | 0.714 |
FGFR2 |
0.676 | -0.081 | 3 | 0.742 |
JAK2 |
0.676 | -0.180 | 1 | 0.610 |
PTK2 |
0.676 | 0.077 | -1 | 0.746 |
TNK2 |
0.675 | -0.044 | 3 | 0.688 |
EPHA8 |
0.675 | 0.038 | -1 | 0.805 |
ERBB2 |
0.674 | -0.009 | 1 | 0.573 |
MERTK |
0.674 | -0.032 | 3 | 0.719 |
DDR1 |
0.674 | -0.188 | 4 | 0.763 |
EPHA3 |
0.673 | -0.023 | 2 | 0.739 |
EGFR |
0.673 | 0.014 | 1 | 0.489 |
FLT3 |
0.673 | -0.087 | 3 | 0.705 |
BTK |
0.673 | -0.043 | -1 | 0.729 |
TEK |
0.672 | -0.068 | 3 | 0.660 |
PTK6 |
0.671 | -0.084 | -1 | 0.686 |
FGFR3 |
0.671 | -0.045 | 3 | 0.712 |
ZAP70 |
0.669 | 0.106 | -1 | 0.686 |
FGFR1 |
0.668 | -0.125 | 3 | 0.709 |
MATK |
0.668 | -0.027 | -1 | 0.706 |
TNNI3K_TYR |
0.668 | -0.119 | 1 | 0.639 |
WEE1_TYR |
0.667 | -0.072 | -1 | 0.683 |
PDGFRB |
0.667 | -0.161 | 3 | 0.725 |
LTK |
0.667 | -0.087 | 3 | 0.684 |
NEK10_TYR |
0.666 | -0.165 | 1 | 0.530 |
PTK2B |
0.666 | -0.018 | -1 | 0.734 |
AXL |
0.664 | -0.124 | 3 | 0.711 |
EPHA2 |
0.664 | 0.010 | -1 | 0.771 |
ERBB4 |
0.664 | 0.047 | 1 | 0.515 |
ALK |
0.664 | -0.101 | 3 | 0.658 |
EPHA1 |
0.664 | -0.069 | 3 | 0.690 |
FGFR4 |
0.662 | -0.033 | -1 | 0.750 |
NTRK1 |
0.662 | -0.143 | -1 | 0.771 |
NTRK3 |
0.661 | -0.089 | -1 | 0.746 |
JAK1 |
0.661 | -0.150 | 1 | 0.533 |
FLT4 |
0.661 | -0.120 | 3 | 0.686 |
INSR |
0.659 | -0.116 | 3 | 0.647 |
PDGFRA |
0.658 | -0.221 | 3 | 0.718 |
NTRK2 |
0.658 | -0.157 | 3 | 0.690 |
CSK |
0.655 | -0.104 | 2 | 0.762 |
TNK1 |
0.655 | -0.217 | 3 | 0.703 |
DDR2 |
0.649 | -0.157 | 3 | 0.671 |
IGF1R |
0.648 | -0.089 | 3 | 0.602 |
FES |
0.643 | -0.047 | -1 | 0.679 |
MUSK |
0.642 | -0.124 | 1 | 0.494 |