Motif 652 (n=102)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A8MVW0 | FAM171A2 | S424 | ochoa | Protein FAM171A2 | None |
| C4P0D8 | TSNAX-DISC1 | S32 | ochoa | Disrupted in schizophrenia 1 isoform 51 (TSNAX-DISC1 readthrough (NMD candidate)) | None |
| O43143 | DHX15 | S64 | ochoa | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}. |
| O43248 | HOXC11 | S210 | ochoa | Homeobox protein Hox-C11 (Homeobox protein Hox-3H) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. |
| O43561 | LAT | S213 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O75695 | RP2 | S28 | ochoa | Protein XRP2 | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}. |
| O94898 | LRIG2 | S913 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) | None |
| O95613 | PCNT | S1703 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95810 | CAVIN2 | S169 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P01111 | NRAS | S39 | ochoa | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:30712867}. |
| P01112 | HRAS | S39 | ochoa | GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] | Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}. |
| P01116 | KRAS | S39 | ochoa | GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:39809765}. |
| P05023 | ATP1A1 | S499 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P0C7T5 | ATXN1L | S346 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0CG23 | ZNF853 | S62 | ochoa | Zinc finger protein 853 | None |
| P11142 | HSPA8 | S153 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P13533 | MYH6 | S1301 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P16284 | PECAM1 | S686 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P21333 | FLNA | S1981 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21728 | DRD1 | S254 | psp | D(1A) dopamine receptor (Dopamine D1 receptor) | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| P28715 | ERCC5 | S1032 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P32004 | L1CAM | S1191 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P38646 | HSPA9 | S200 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P46939 | UTRN | S2615 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48681 | NES | S1590 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P52565 | ARHGDIA | Y27 | ochoa|psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P54760 | EPHB4 | S613 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P61224 | RAP1B | S39 | ochoa | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}. |
| P62834 | RAP1A | S39 | ochoa | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:25208567}. |
| P62857 | RPS28 | S39 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| P82094 | TMF1 | S396 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q02108 | GUCY1A1 | S58 | ochoa | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | None |
| Q03164 | KMT2A | S992 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q12768 | WASHC5 | S999 | ochoa | WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20833645, ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}. |
| Q12834 | CDC20 | S134 | ochoa | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q13936 | CACNA1C | Y1920 | psp | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q14004 | CDK13 | S867 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14103 | HNRNPD | S82 | ochoa | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q14315 | FLNC | S762 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14966 | ZNF638 | S1658 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15057 | ACAP2 | S378 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15398 | DLGAP5 | S787 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q16531 | DDB1 | S1101 | ochoa | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}. |
| Q3MHD2 | LSM12 | S157 | ochoa | Protein LSM12 | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892). {ECO:0000269|PubMed:34362892}. |
| Q5T1M5 | FKBP15 | S1195 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5VT25 | CDC42BPA | S672 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VYS8 | TUT7 | S85 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q6FI81 | CIAPIN1 | S287 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6PFW1 | PPIP5K1 | S944 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6ZNJ1 | NBEAL2 | S1873 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q7Z402 | TMC7 | S86 | ochoa | Transmembrane channel-like protein 7 | Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}. |
| Q7Z4V5 | HDGFL2 | S194 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z569 | BRAP | S97 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q7Z5L2 | R3HCC1L | S338 | ochoa | Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) | None |
| Q7Z6I6 | ARHGAP30 | S865 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6J6 | FRMD5 | S465 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86V15 | CASZ1 | S213 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86X02 | CDR2L | S417 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IUG5 | MYO18B | S24 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IY81 | FTSJ3 | S598 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8IY92 | SLX4 | S57 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N3C0 | ASCC3 | S446 | ochoa | Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q8N8S7 | ENAH | S541 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8TEQ6 | GEMIN5 | S770 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TF76 | HASPIN | S269 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q92576 | PHF3 | S419 | ochoa | PHD finger protein 3 | None |
| Q96B97 | SH3KBP1 | S521 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96L93 | KIF16B | S1100 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96PZ0 | PUS7 | S36 | ochoa | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| Q96R06 | SPAG5 | S401 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RL1 | UIMC1 | S415 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99570 | PIK3R4 | S865 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99590 | SCAF11 | S588 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99598 | TSNAX | S32 | ochoa | Translin-associated protein X (Translin-associated factor X) | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}. |
| Q9BPX3 | NCAPG | S390 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BSQ5 | CCM2 | S266 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BXW6 | OSBPL1A | S509 | ochoa | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}. |
| Q9H1H9 | KIF13A | S848 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H3K6 | BOLA2 | S32 | ochoa | BolA-like protein 2 | Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| Q9HAU0 | PLEKHA5 | S120 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NYV4 | CDK12 | S889 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P0T7 | TMEM9 | S137 | ochoa | Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9) | Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). {ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32380568}. |
| Q9UBT7 | CTNNAL1 | S538 | ochoa | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). |
| Q9UKL3 | CASP8AP2 | S658 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UNS1 | TIMELESS | S126 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9Y4L1 | HYOU1 | S964 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| R4GMW8 | BIVM-ERCC5 | S1486 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q92621 | NUP205 | S1857 | Sugiyama | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| P05787 | KRT8 | S330 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P30566 | ADSL | S407 | Sugiyama | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| O60566 | BUB1B | S220 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60566 | BUB1B | S99 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q8WUA2 | PPIL4 | Y401 | Sugiyama | Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}. |
| Q96CN4 | EVI5L | S494 | Sugiyama | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| P09132 | SRP19 | S69 | Sugiyama | Signal recognition particle 19 kDa protein (SRP19) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity). {ECO:0000250|UniProtKB:J9PAS6}. |
| P49137 | MAPKAPK2 | S358 | Sugiyama | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
| Q16644 | MAPKAPK3 | S337 | Sugiyama | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}. |
| Q13526 | PIN1 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| P57059 | SIK1 | S463 | Sugiyama | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| O43707 | ACTN4 | S796 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P17980 | PSMC3 | S170 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q8IW41 | MAPKAPK5 | S33 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6802949 | Signaling by RAS mutants | 7.364436e-09 | 8.133 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 7.364436e-09 | 8.133 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 7.364436e-09 | 8.133 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 7.364436e-09 | 8.133 |
| R-HSA-171007 | p38MAPK events | 7.163835e-09 | 8.145 |
| R-HSA-187687 | Signalling to ERKs | 2.986052e-08 | 7.525 |
| R-HSA-167044 | Signalling to RAS | 4.515354e-08 | 7.345 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.518992e-07 | 6.345 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 6.645689e-07 | 6.177 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 9.547931e-07 | 6.020 |
| R-HSA-112412 | SOS-mediated signalling | 1.007297e-06 | 5.997 |
| R-HSA-1169092 | Activation of RAS in B cells | 1.466616e-06 | 5.834 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.768877e-06 | 5.752 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.768877e-06 | 5.752 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 2.065662e-06 | 5.685 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 2.829416e-06 | 5.548 |
| R-HSA-9753510 | Signaling by RAS GAP mutants | 3.803924e-06 | 5.420 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 3.784643e-06 | 5.422 |
| R-HSA-6806834 | Signaling by MET | 4.034019e-06 | 5.394 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 4.959841e-06 | 5.305 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 6.385178e-06 | 5.195 |
| R-HSA-8851805 | MET activates RAS signaling | 6.385178e-06 | 5.195 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 6.385178e-06 | 5.195 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 6.385178e-06 | 5.195 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 6.385178e-06 | 5.195 |
| R-HSA-2424491 | DAP12 signaling | 7.286665e-06 | 5.137 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.011498e-05 | 4.995 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.248766e-05 | 4.904 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.248766e-05 | 4.904 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.248766e-05 | 4.904 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.248766e-05 | 4.904 |
| R-HSA-5673000 | RAF activation | 1.356805e-05 | 4.867 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.504018e-05 | 4.823 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.681514e-05 | 4.774 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.681514e-05 | 4.774 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.843014e-05 | 4.734 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.843014e-05 | 4.734 |
| R-HSA-9648002 | RAS processing | 2.344103e-05 | 4.630 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.207676e-05 | 4.656 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.207676e-05 | 4.656 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.622705e-05 | 4.581 |
| R-HSA-210993 | Tie2 Signaling | 2.622705e-05 | 4.581 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.092267e-05 | 4.510 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.160278e-05 | 4.500 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.661259e-05 | 4.436 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.871601e-05 | 4.312 |
| R-HSA-2172127 | DAP12 interactions | 4.181399e-05 | 4.379 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 4.212256e-05 | 4.375 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 4.871601e-05 | 4.312 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 4.871601e-05 | 4.312 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.212256e-05 | 4.375 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.212256e-05 | 4.375 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.871601e-05 | 4.312 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.871601e-05 | 4.312 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 5.603309e-05 | 4.252 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 5.603309e-05 | 4.252 |
| R-HSA-9669938 | Signaling by KIT in disease | 5.603309e-05 | 4.252 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.975466e-05 | 4.156 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 7.302817e-05 | 4.137 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 7.302817e-05 | 4.137 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 7.302817e-05 | 4.137 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 7.302817e-05 | 4.137 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 8.280362e-05 | 4.082 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 8.280362e-05 | 4.082 |
| R-HSA-447115 | Interleukin-12 family signaling | 7.608068e-05 | 4.119 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.686453e-05 | 4.061 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.729542e-05 | 4.059 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 9.349752e-05 | 4.029 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 9.349752e-05 | 4.029 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.042193e-04 | 3.982 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.051608e-04 | 3.978 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.051608e-04 | 3.978 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 1.051608e-04 | 3.978 |
| R-HSA-177929 | Signaling by EGFR | 1.102739e-04 | 3.958 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.178454e-04 | 3.929 |
| R-HSA-112399 | IRS-mediated signalling | 1.184852e-04 | 3.926 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.316037e-04 | 3.881 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.316037e-04 | 3.881 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.316037e-04 | 3.881 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.464891e-04 | 3.834 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.464891e-04 | 3.834 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.464891e-04 | 3.834 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.561145e-04 | 3.807 |
| R-HSA-186763 | Downstream signal transduction | 1.625557e-04 | 3.789 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.668068e-04 | 3.778 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.898624e-04 | 3.722 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.022636e-04 | 3.694 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.984517e-04 | 3.702 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.898624e-04 | 3.722 |
| R-HSA-166520 | Signaling by NTRKs | 2.166098e-04 | 3.664 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.625422e-04 | 3.581 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 2.625422e-04 | 3.581 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.737888e-04 | 3.563 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.868656e-04 | 3.542 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.868656e-04 | 3.542 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.072208e-04 | 3.513 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.136600e-04 | 3.504 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.698284e-04 | 3.432 |
| R-HSA-9675108 | Nervous system development | 4.259850e-04 | 3.371 |
| R-HSA-9607240 | FLT3 Signaling | 4.333016e-04 | 3.363 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.431556e-04 | 3.265 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.679671e-04 | 3.330 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.431556e-04 | 3.265 |
| R-HSA-194138 | Signaling by VEGF | 5.669655e-04 | 3.246 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.265583e-04 | 3.203 |
| R-HSA-422475 | Axon guidance | 8.254423e-04 | 3.083 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 8.742077e-04 | 3.058 |
| R-HSA-74752 | Signaling by Insulin receptor | 9.135369e-04 | 3.039 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.253984e-03 | 2.902 |
| R-HSA-8953854 | Metabolism of RNA | 1.287325e-03 | 2.890 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.563377e-03 | 2.806 |
| R-HSA-186797 | Signaling by PDGF | 1.736406e-03 | 2.760 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.817602e-03 | 2.741 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.827716e-03 | 2.738 |
| R-HSA-8848021 | Signaling by PTK6 | 1.827716e-03 | 2.738 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 2.141520e-03 | 2.669 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.061556e-03 | 2.514 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.061556e-03 | 2.514 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 4.089285e-03 | 2.388 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.929691e-03 | 2.406 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.327569e-03 | 2.273 |
| R-HSA-109582 | Hemostasis | 5.418787e-03 | 2.266 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.617648e-03 | 2.250 |
| R-HSA-449147 | Signaling by Interleukins | 7.120015e-03 | 2.148 |
| R-HSA-168256 | Immune System | 7.577710e-03 | 2.120 |
| R-HSA-190236 | Signaling by FGFR | 8.248452e-03 | 2.084 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 8.493324e-03 | 2.071 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.045834e-03 | 2.044 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.322406e-03 | 2.030 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.322406e-03 | 2.030 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 9.367049e-03 | 2.028 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9.589178e-03 | 2.018 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.027909e-02 | 1.988 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.027909e-02 | 1.988 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.122887e-02 | 1.950 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.002479e-02 | 1.999 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.093014e-02 | 1.961 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.139998e-02 | 1.943 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.221581e-02 | 1.913 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 1.106462e-02 | 1.956 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.247672e-02 | 1.904 |
| R-HSA-392517 | Rap1 signalling | 1.323932e-02 | 1.878 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.446227e-02 | 1.840 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.539385e-02 | 1.813 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.539385e-02 | 1.813 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.574621e-02 | 1.803 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.652374e-02 | 1.782 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.655682e-02 | 1.781 |
| R-HSA-3371556 | Cellular response to heat stress | 1.685449e-02 | 1.773 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.984917e-02 | 1.702 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.984917e-02 | 1.702 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.007900e-02 | 1.697 |
| R-HSA-1280218 | Adaptive Immune System | 2.155394e-02 | 1.666 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.267773e-02 | 1.644 |
| R-HSA-6798695 | Neutrophil degranulation | 2.269492e-02 | 1.644 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.400572e-02 | 1.620 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.675474e-02 | 1.573 |
| R-HSA-209563 | Axonal growth stimulation | 3.538259e-02 | 1.451 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.571035e-02 | 1.447 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.571035e-02 | 1.447 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.730119e-02 | 1.428 |
| R-HSA-354192 | Integrin signaling | 3.261097e-02 | 1.487 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.414679e-02 | 1.467 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.014381e-02 | 1.521 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.817477e-02 | 1.550 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.638525e-02 | 1.439 |
| R-HSA-168249 | Innate Immune System | 3.312403e-02 | 1.480 |
| R-HSA-8875878 | MET promotes cell motility | 4.223274e-02 | 1.374 |
| R-HSA-390651 | Dopamine receptors | 4.230873e-02 | 1.374 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.564844e-02 | 1.341 |
| R-HSA-202433 | Generation of second messenger molecules | 4.564844e-02 | 1.341 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.884388e-02 | 1.311 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 4.918555e-02 | 1.308 |
| R-HSA-8866376 | Reelin signalling pathway | 4.918555e-02 | 1.308 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 5.095514e-02 | 1.293 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.461004e-02 | 1.263 |
| R-HSA-176417 | Phosphorylation of Emi1 | 5.601342e-02 | 1.252 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.647135e-02 | 1.248 |
| R-HSA-73894 | DNA Repair | 5.754402e-02 | 1.240 |
| R-HSA-202403 | TCR signaling | 5.873298e-02 | 1.231 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 7.620673e-02 | 1.118 |
| R-HSA-9613354 | Lipophagy | 8.284221e-02 | 1.082 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.025966e-02 | 1.220 |
| R-HSA-6782135 | Dual incision in TC-NER | 8.252987e-02 | 1.083 |
| R-HSA-191859 | snRNP Assembly | 8.466429e-02 | 1.072 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.466429e-02 | 1.072 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.876049e-02 | 1.163 |
| R-HSA-72172 | mRNA Splicing | 7.934190e-02 | 1.100 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.579999e-02 | 1.182 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 7.212140e-02 | 1.142 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 8.284221e-02 | 1.082 |
| R-HSA-170984 | ARMS-mediated activation | 8.284221e-02 | 1.082 |
| R-HSA-68877 | Mitotic Prometaphase | 6.783731e-02 | 1.169 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 7.620673e-02 | 1.118 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 7.416674e-02 | 1.130 |
| R-HSA-114608 | Platelet degranulation | 8.374723e-02 | 1.077 |
| R-HSA-199920 | CREB phosphorylation | 6.279268e-02 | 1.202 |
| R-HSA-397014 | Muscle contraction | 8.751917e-02 | 1.058 |
| R-HSA-68886 | M Phase | 7.195327e-02 | 1.143 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 6.279268e-02 | 1.202 |
| R-HSA-447041 | CHL1 interactions | 6.952367e-02 | 1.158 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.340857e-02 | 1.198 |
| R-HSA-450294 | MAP kinase activation | 8.898303e-02 | 1.051 |
| R-HSA-1266738 | Developmental Biology | 7.048660e-02 | 1.152 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.284221e-02 | 1.082 |
| R-HSA-5693538 | Homology Directed Repair | 7.073491e-02 | 1.150 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.580943e-02 | 1.182 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.623063e-02 | 1.118 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.751917e-02 | 1.058 |
| R-HSA-68882 | Mitotic Anaphase | 9.175610e-02 | 1.037 |
| R-HSA-9909396 | Circadian clock | 9.201261e-02 | 1.036 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.283054e-02 | 1.032 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.342221e-02 | 1.030 |
| R-HSA-210990 | PECAM1 interactions | 9.597172e-02 | 1.018 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.020656e-01 | 0.991 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.024664e-01 | 0.989 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.024664e-01 | 0.989 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.027892e-01 | 0.988 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.050420e-01 | 0.979 |
| R-HSA-1632852 | Macroautophagy | 1.065034e-01 | 0.973 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.089149e-01 | 0.963 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.089149e-01 | 0.963 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.089149e-01 | 0.963 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.089149e-01 | 0.963 |
| R-HSA-8983711 | OAS antiviral response | 1.089149e-01 | 0.963 |
| R-HSA-448424 | Interleukin-17 signaling | 1.091744e-01 | 0.962 |
| R-HSA-3928664 | Ephrin signaling | 1.527859e-01 | 0.816 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.588758e-01 | 0.799 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.475721e-01 | 0.831 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.475721e-01 | 0.831 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.753364e-01 | 0.756 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.908137e-01 | 0.719 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.117164e-01 | 0.674 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.208674e-01 | 0.918 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.064669e-01 | 0.685 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.404746e-01 | 0.852 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.117686e-01 | 0.674 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.426280e-01 | 0.846 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.676779e-01 | 0.776 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.563718e-01 | 0.806 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.404746e-01 | 0.852 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.527859e-01 | 0.816 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.445291e-01 | 0.840 |
| R-HSA-445144 | Signal transduction by L1 | 1.649224e-01 | 0.783 |
| R-HSA-170968 | Frs2-mediated activation | 1.153174e-01 | 0.938 |
| R-HSA-169893 | Prolonged ERK activation events | 1.342526e-01 | 0.872 |
| R-HSA-8949613 | Cristae formation | 2.117686e-01 | 0.674 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.174381e-01 | 0.663 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.138142e-01 | 0.944 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.881041e-01 | 0.726 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.527859e-01 | 0.816 |
| R-HSA-73942 | DNA Damage Reversal | 1.279859e-01 | 0.893 |
| R-HSA-9612973 | Autophagy | 1.313861e-01 | 0.881 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.466523e-01 | 0.834 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.945147e-01 | 0.711 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.426280e-01 | 0.846 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.143462e-01 | 0.669 |
| R-HSA-9663891 | Selective autophagy | 1.550530e-01 | 0.810 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.280258e-01 | 0.893 |
| R-HSA-9830674 | Formation of the ureteric bud | 1.886806e-01 | 0.724 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.230671e-01 | 0.652 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.279859e-01 | 0.893 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.279859e-01 | 0.893 |
| R-HSA-429947 | Deadenylation of mRNA | 1.945147e-01 | 0.711 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.003072e-01 | 0.698 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.352818e-01 | 0.869 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.060584e-01 | 0.686 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.169792e-01 | 0.664 |
| R-HSA-418346 | Platelet homeostasis | 2.090899e-01 | 0.680 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.417669e-01 | 0.848 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.279859e-01 | 0.893 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.649224e-01 | 0.783 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.060584e-01 | 0.686 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.060584e-01 | 0.686 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.768865e-01 | 0.752 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.216743e-01 | 0.915 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.466523e-01 | 0.834 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.886806e-01 | 0.724 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.153174e-01 | 0.938 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.208674e-01 | 0.918 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.500573e-01 | 0.824 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.265726e-01 | 0.898 |
| R-HSA-8876725 | Protein methylation | 1.279859e-01 | 0.893 |
| R-HSA-422356 | Regulation of insulin secretion | 1.856328e-01 | 0.731 |
| R-HSA-210991 | Basigin interactions | 1.709258e-01 | 0.767 |
| R-HSA-9865881 | Complex III assembly | 1.945147e-01 | 0.711 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.060584e-01 | 0.686 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.157097e-01 | 0.666 |
| R-HSA-2559583 | Cellular Senescence | 1.737904e-01 | 0.760 |
| R-HSA-373753 | Nephrin family interactions | 1.649224e-01 | 0.783 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.003072e-01 | 0.698 |
| R-HSA-162582 | Signal Transduction | 1.988835e-01 | 0.701 |
| R-HSA-2262752 | Cellular responses to stress | 1.292065e-01 | 0.889 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.347068e-01 | 0.871 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.143462e-01 | 0.669 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.230671e-01 | 0.652 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.856328e-01 | 0.731 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.856328e-01 | 0.731 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.856328e-01 | 0.731 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.169792e-01 | 0.664 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.525511e-01 | 0.817 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.196152e-01 | 0.658 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.196152e-01 | 0.658 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.064669e-01 | 0.685 |
| R-HSA-211000 | Gene Silencing by RNA | 2.117164e-01 | 0.674 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.230671e-01 | 0.652 |
| R-HSA-1483255 | PI Metabolism | 1.960140e-01 | 0.708 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.830503e-01 | 0.737 |
| R-HSA-391251 | Protein folding | 1.676779e-01 | 0.776 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.527859e-01 | 0.816 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.828047e-01 | 0.738 |
| R-HSA-416476 | G alpha (q) signalling events | 1.496615e-01 | 0.825 |
| R-HSA-8939211 | ESR-mediated signaling | 1.155520e-01 | 0.937 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.935499e-01 | 0.713 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.500573e-01 | 0.824 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.651384e-01 | 0.782 |
| R-HSA-1500931 | Cell-Cell communication | 2.242560e-01 | 0.649 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.248954e-01 | 0.648 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.275393e-01 | 0.643 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.286560e-01 | 0.641 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.286560e-01 | 0.641 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.342051e-01 | 0.630 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.342051e-01 | 0.630 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.342051e-01 | 0.630 |
| R-HSA-182971 | EGFR downregulation | 2.342051e-01 | 0.630 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.342051e-01 | 0.630 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.342051e-01 | 0.630 |
| R-HSA-9679506 | SARS-CoV Infections | 2.360689e-01 | 0.627 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.397145e-01 | 0.620 |
| R-HSA-373760 | L1CAM interactions | 2.407896e-01 | 0.618 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.451847e-01 | 0.611 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.451847e-01 | 0.611 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.451847e-01 | 0.611 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.451847e-01 | 0.611 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.487589e-01 | 0.604 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.487589e-01 | 0.604 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.491345e-01 | 0.604 |
| R-HSA-390522 | Striated Muscle Contraction | 2.506158e-01 | 0.601 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.506158e-01 | 0.601 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.506158e-01 | 0.601 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.506158e-01 | 0.601 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 2.506158e-01 | 0.601 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.506158e-01 | 0.601 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.506158e-01 | 0.601 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.506158e-01 | 0.601 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.540770e-01 | 0.595 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.560082e-01 | 0.592 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.560082e-01 | 0.592 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.560082e-01 | 0.592 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.560082e-01 | 0.592 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.560082e-01 | 0.592 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.560082e-01 | 0.592 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.567372e-01 | 0.591 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.567372e-01 | 0.591 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.593980e-01 | 0.586 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.613622e-01 | 0.583 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.613622e-01 | 0.583 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.613622e-01 | 0.583 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 2.613622e-01 | 0.583 |
| R-HSA-169911 | Regulation of Apoptosis | 2.613622e-01 | 0.583 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.620592e-01 | 0.582 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.666779e-01 | 0.574 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.666779e-01 | 0.574 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.666779e-01 | 0.574 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.719557e-01 | 0.566 |
| R-HSA-4641258 | Degradation of DVL | 2.719557e-01 | 0.566 |
| R-HSA-4641257 | Degradation of AXIN | 2.719557e-01 | 0.566 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.719557e-01 | 0.566 |
| R-HSA-419037 | NCAM1 interactions | 2.719557e-01 | 0.566 |
| R-HSA-69481 | G2/M Checkpoints | 2.727054e-01 | 0.564 |
| R-HSA-1640170 | Cell Cycle | 2.727226e-01 | 0.564 |
| R-HSA-72312 | rRNA processing | 2.730848e-01 | 0.564 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.758158e-01 | 0.559 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.771959e-01 | 0.557 |
| R-HSA-112316 | Neuronal System | 2.774020e-01 | 0.557 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.823986e-01 | 0.549 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.823986e-01 | 0.549 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.823986e-01 | 0.549 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.823986e-01 | 0.549 |
| R-HSA-69541 | Stabilization of p53 | 2.823986e-01 | 0.549 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.823986e-01 | 0.549 |
| R-HSA-5576891 | Cardiac conduction | 2.860063e-01 | 0.544 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.875642e-01 | 0.541 |
| R-HSA-9646399 | Aggrephagy | 2.875642e-01 | 0.541 |
| R-HSA-3371568 | Attenuation phase | 2.875642e-01 | 0.541 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.875642e-01 | 0.541 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.875642e-01 | 0.541 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.875642e-01 | 0.541 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.875642e-01 | 0.541 |
| R-HSA-157118 | Signaling by NOTCH | 2.886945e-01 | 0.540 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.926930e-01 | 0.534 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.926930e-01 | 0.534 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.926930e-01 | 0.534 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.926930e-01 | 0.534 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 2.926930e-01 | 0.534 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.926930e-01 | 0.534 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.977851e-01 | 0.526 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.977851e-01 | 0.526 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.977851e-01 | 0.526 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.977851e-01 | 0.526 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.982938e-01 | 0.525 |
| R-HSA-163685 | Integration of energy metabolism | 3.019361e-01 | 0.520 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.019361e-01 | 0.520 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.028409e-01 | 0.519 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.078606e-01 | 0.512 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.098807e-01 | 0.509 |
| R-HSA-9907900 | Proteasome assembly | 3.128445e-01 | 0.505 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.128445e-01 | 0.505 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 3.128445e-01 | 0.505 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.128445e-01 | 0.505 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.177928e-01 | 0.498 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.177928e-01 | 0.498 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.177928e-01 | 0.498 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.177928e-01 | 0.498 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.177928e-01 | 0.498 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.177928e-01 | 0.498 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.177928e-01 | 0.498 |
| R-HSA-9824272 | Somitogenesis | 3.177928e-01 | 0.498 |
| R-HSA-5688426 | Deubiquitination | 3.181290e-01 | 0.497 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.204457e-01 | 0.494 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.227058e-01 | 0.491 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.227058e-01 | 0.491 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.227058e-01 | 0.491 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.227058e-01 | 0.491 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.227058e-01 | 0.491 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.230812e-01 | 0.491 |
| R-HSA-437239 | Recycling pathway of L1 | 3.275837e-01 | 0.485 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.275837e-01 | 0.485 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.275837e-01 | 0.485 |
| R-HSA-913531 | Interferon Signaling | 3.324038e-01 | 0.478 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.324268e-01 | 0.478 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.362200e-01 | 0.473 |
| R-HSA-9766229 | Degradation of CDH1 | 3.372352e-01 | 0.472 |
| R-HSA-73893 | DNA Damage Bypass | 3.372352e-01 | 0.472 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.372352e-01 | 0.472 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.372352e-01 | 0.472 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.414555e-01 | 0.467 |
| R-HSA-109704 | PI3K Cascade | 3.420094e-01 | 0.466 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.466783e-01 | 0.460 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.467494e-01 | 0.460 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.467494e-01 | 0.460 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.467494e-01 | 0.460 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.467494e-01 | 0.460 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.514556e-01 | 0.454 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.514556e-01 | 0.454 |
| R-HSA-73887 | Death Receptor Signaling | 3.518880e-01 | 0.454 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.544876e-01 | 0.450 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.561282e-01 | 0.448 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.561282e-01 | 0.448 |
| R-HSA-8956320 | Nucleotide biosynthesis | 3.561282e-01 | 0.448 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.561282e-01 | 0.448 |
| R-HSA-72649 | Translation initiation complex formation | 3.607674e-01 | 0.443 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.607674e-01 | 0.443 |
| R-HSA-446728 | Cell junction organization | 3.633205e-01 | 0.440 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.674304e-01 | 0.435 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.699466e-01 | 0.432 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.699466e-01 | 0.432 |
| R-HSA-5578775 | Ion homeostasis | 3.699466e-01 | 0.432 |
| R-HSA-75893 | TNF signaling | 3.699466e-01 | 0.432 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.744871e-01 | 0.427 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.744871e-01 | 0.427 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.789951e-01 | 0.421 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.789951e-01 | 0.421 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.834710e-01 | 0.416 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.834710e-01 | 0.416 |
| R-HSA-983189 | Kinesins | 3.879148e-01 | 0.411 |
| R-HSA-351202 | Metabolism of polyamines | 3.879148e-01 | 0.411 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.923269e-01 | 0.406 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.923269e-01 | 0.406 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.923269e-01 | 0.406 |
| R-HSA-72306 | tRNA processing | 3.955424e-01 | 0.403 |
| R-HSA-1483257 | Phospholipid metabolism | 3.964656e-01 | 0.402 |
| R-HSA-1268020 | Mitochondrial protein import | 3.967075e-01 | 0.402 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.967075e-01 | 0.402 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.967075e-01 | 0.402 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.967075e-01 | 0.402 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.967075e-01 | 0.402 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.005946e-01 | 0.397 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.010567e-01 | 0.397 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.010567e-01 | 0.397 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.010567e-01 | 0.397 |
| R-HSA-6799198 | Complex I biogenesis | 4.010567e-01 | 0.397 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.010567e-01 | 0.397 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.031135e-01 | 0.395 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.053749e-01 | 0.392 |
| R-HSA-72766 | Translation | 4.074870e-01 | 0.390 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.081364e-01 | 0.389 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.096622e-01 | 0.388 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.139188e-01 | 0.383 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.139188e-01 | 0.383 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.139188e-01 | 0.383 |
| R-HSA-168255 | Influenza Infection | 4.181212e-01 | 0.379 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.181450e-01 | 0.379 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.181450e-01 | 0.379 |
| R-HSA-9830369 | Kidney development | 4.181450e-01 | 0.379 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.223411e-01 | 0.374 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.223411e-01 | 0.374 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.306433e-01 | 0.366 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.306433e-01 | 0.366 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.347499e-01 | 0.362 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.347499e-01 | 0.362 |
| R-HSA-69275 | G2/M Transition | 4.353902e-01 | 0.361 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.388272e-01 | 0.358 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.388272e-01 | 0.358 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.388272e-01 | 0.358 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.388272e-01 | 0.358 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.402744e-01 | 0.356 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.428753e-01 | 0.354 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.428753e-01 | 0.354 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.428753e-01 | 0.354 |
| R-HSA-4086398 | Ca2+ pathway | 4.428753e-01 | 0.354 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.443391e-01 | 0.352 |
| R-HSA-5617833 | Cilium Assembly | 4.451357e-01 | 0.352 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.468945e-01 | 0.350 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.468945e-01 | 0.350 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.499740e-01 | 0.347 |
| R-HSA-380287 | Centrosome maturation | 4.508849e-01 | 0.346 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.508849e-01 | 0.346 |
| R-HSA-5689603 | UCH proteinases | 4.548468e-01 | 0.342 |
| R-HSA-5619084 | ABC transporter disorders | 4.626857e-01 | 0.335 |
| R-HSA-4086400 | PCP/CE pathway | 4.626857e-01 | 0.335 |
| R-HSA-216083 | Integrin cell surface interactions | 4.626857e-01 | 0.335 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.652280e-01 | 0.332 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.690888e-01 | 0.329 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.690888e-01 | 0.329 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.704129e-01 | 0.328 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.704129e-01 | 0.328 |
| R-HSA-9833482 | PKR-mediated signaling | 4.704129e-01 | 0.328 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.780299e-01 | 0.321 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.817975e-01 | 0.317 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.855382e-01 | 0.314 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.929395e-01 | 0.307 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.038440e-01 | 0.298 |
| R-HSA-156902 | Peptide chain elongation | 5.038440e-01 | 0.298 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.074269e-01 | 0.295 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.109841e-01 | 0.292 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.109841e-01 | 0.292 |
| R-HSA-202424 | Downstream TCR signaling | 5.109841e-01 | 0.292 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.145159e-01 | 0.289 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.180224e-01 | 0.286 |
| R-HSA-8951664 | Neddylation | 5.195720e-01 | 0.284 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.215037e-01 | 0.283 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.249602e-01 | 0.280 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.249602e-01 | 0.280 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.283919e-01 | 0.277 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.305984e-01 | 0.275 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.317990e-01 | 0.274 |
| R-HSA-162906 | HIV Infection | 5.327833e-01 | 0.273 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.351817e-01 | 0.271 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.351817e-01 | 0.271 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.351817e-01 | 0.271 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.385402e-01 | 0.269 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.385402e-01 | 0.269 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.385402e-01 | 0.269 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.484719e-01 | 0.261 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.484719e-01 | 0.261 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.517352e-01 | 0.258 |
| R-HSA-70171 | Glycolysis | 5.517352e-01 | 0.258 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.517352e-01 | 0.258 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.549751e-01 | 0.256 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.549751e-01 | 0.256 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.590771e-01 | 0.253 |
| R-HSA-192823 | Viral mRNA Translation | 5.613854e-01 | 0.251 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.645561e-01 | 0.248 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.645561e-01 | 0.248 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.645561e-01 | 0.248 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.739326e-01 | 0.241 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.750246e-01 | 0.240 |
| R-HSA-69239 | Synthesis of DNA | 5.770134e-01 | 0.239 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.800721e-01 | 0.237 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.800721e-01 | 0.237 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.800721e-01 | 0.237 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.831089e-01 | 0.234 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.861239e-01 | 0.232 |
| R-HSA-9824446 | Viral Infection Pathways | 5.903681e-01 | 0.229 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.920892e-01 | 0.228 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.920892e-01 | 0.228 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.931169e-01 | 0.227 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.979692e-01 | 0.223 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.066321e-01 | 0.217 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.067922e-01 | 0.217 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.094784e-01 | 0.215 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.094784e-01 | 0.215 |
| R-HSA-70326 | Glucose metabolism | 6.123043e-01 | 0.213 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.123043e-01 | 0.213 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.178954e-01 | 0.209 |
| R-HSA-68875 | Mitotic Prophase | 6.206609e-01 | 0.207 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.234065e-01 | 0.205 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.288388e-01 | 0.201 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.315258e-01 | 0.200 |
| R-HSA-69206 | G1/S Transition | 6.368420e-01 | 0.196 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.421643e-01 | 0.192 |
| R-HSA-9843745 | Adipogenesis | 6.548569e-01 | 0.184 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.573570e-01 | 0.182 |
| R-HSA-195721 | Signaling by WNT | 6.699897e-01 | 0.174 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.719854e-01 | 0.173 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.743625e-01 | 0.171 |
| R-HSA-6807070 | PTEN Regulation | 6.767226e-01 | 0.170 |
| R-HSA-388396 | GPCR downstream signalling | 6.831161e-01 | 0.166 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.859944e-01 | 0.164 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.905310e-01 | 0.161 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.950025e-01 | 0.158 |
| R-HSA-69242 | S Phase | 6.994101e-01 | 0.155 |
| R-HSA-9758941 | Gastrulation | 7.015901e-01 | 0.154 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.037544e-01 | 0.153 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.059032e-01 | 0.151 |
| R-HSA-2142753 | Arachidonate metabolism | 7.080365e-01 | 0.150 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.080365e-01 | 0.150 |
| R-HSA-9609507 | Protein localization | 7.101545e-01 | 0.149 |
| R-HSA-69306 | DNA Replication | 7.101545e-01 | 0.149 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.122573e-01 | 0.147 |
| R-HSA-199991 | Membrane Trafficking | 7.144859e-01 | 0.146 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.181930e-01 | 0.144 |
| R-HSA-9610379 | HCMV Late Events | 7.184752e-01 | 0.144 |
| R-HSA-162587 | HIV Life Cycle | 7.184752e-01 | 0.144 |
| R-HSA-9711097 | Cellular response to starvation | 7.205181e-01 | 0.142 |
| R-HSA-1474244 | Extracellular matrix organization | 7.218876e-01 | 0.142 |
| R-HSA-109581 | Apoptosis | 7.285437e-01 | 0.138 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.324705e-01 | 0.135 |
| R-HSA-5619102 | SLC transporter disorders | 7.382552e-01 | 0.132 |
| R-HSA-418555 | G alpha (s) signalling events | 7.476221e-01 | 0.126 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.512751e-01 | 0.124 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.512751e-01 | 0.124 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.548757e-01 | 0.122 |
| R-HSA-611105 | Respiratory electron transport | 7.601800e-01 | 0.119 |
| R-HSA-372790 | Signaling by GPCR | 7.638358e-01 | 0.117 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.687686e-01 | 0.114 |
| R-HSA-983712 | Ion channel transport | 7.786733e-01 | 0.109 |
| R-HSA-9609690 | HCMV Early Events | 7.896983e-01 | 0.103 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.896983e-01 | 0.103 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.001785e-01 | 0.097 |
| R-HSA-5357801 | Programmed Cell Death | 8.045100e-01 | 0.094 |
| R-HSA-6805567 | Keratinization | 8.059330e-01 | 0.094 |
| R-HSA-418990 | Adherens junctions interactions | 8.222290e-01 | 0.085 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.418649e-01 | 0.075 |
| R-HSA-15869 | Metabolism of nucleotides | 8.441629e-01 | 0.074 |
| R-HSA-4839726 | Chromatin organization | 8.583142e-01 | 0.066 |
| R-HSA-9609646 | HCMV Infection | 8.593484e-01 | 0.066 |
| R-HSA-421270 | Cell-cell junction organization | 8.603752e-01 | 0.065 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.767353e-01 | 0.057 |
| R-HSA-1643685 | Disease | 8.937243e-01 | 0.049 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.988985e-01 | 0.046 |
| R-HSA-392499 | Metabolism of proteins | 9.072323e-01 | 0.042 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.177127e-01 | 0.037 |
| R-HSA-8957322 | Metabolism of steroids | 9.183162e-01 | 0.037 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.279289e-01 | 0.032 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.284580e-01 | 0.032 |
| R-HSA-5663205 | Infectious disease | 9.349273e-01 | 0.029 |
| R-HSA-212436 | Generic Transcription Pathway | 9.432426e-01 | 0.025 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.471465e-01 | 0.024 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.501696e-01 | 0.022 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.516216e-01 | 0.022 |
| R-HSA-8978868 | Fatty acid metabolism | 9.560572e-01 | 0.020 |
| R-HSA-74160 | Gene expression (Transcription) | 9.577064e-01 | 0.019 |
| R-HSA-597592 | Post-translational protein modification | 9.643415e-01 | 0.016 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.692119e-01 | 0.014 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.695339e-01 | 0.013 |
| R-HSA-556833 | Metabolism of lipids | 9.869384e-01 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 9.886621e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.949552e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.993102e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.835 | 0.176 | 2 | 0.711 |
DSTYK |
0.824 | 0.135 | 2 | 0.726 |
GCN2 |
0.823 | 0.041 | 2 | 0.682 |
TGFBR2 |
0.822 | 0.215 | -2 | 0.881 |
CDC7 |
0.820 | 0.091 | 1 | 0.828 |
RAF1 |
0.819 | 0.104 | 1 | 0.856 |
NEK6 |
0.818 | 0.093 | -2 | 0.856 |
BMPR1B |
0.817 | 0.264 | 1 | 0.791 |
IKKB |
0.816 | -0.016 | -2 | 0.707 |
TBK1 |
0.816 | 0.042 | 1 | 0.760 |
MOS |
0.815 | 0.074 | 1 | 0.829 |
ULK2 |
0.815 | 0.002 | 2 | 0.688 |
PRPK |
0.815 | 0.003 | -1 | 0.863 |
ATR |
0.815 | 0.091 | 1 | 0.836 |
CLK3 |
0.814 | 0.130 | 1 | 0.743 |
MTOR |
0.814 | 0.002 | 1 | 0.780 |
BMPR2 |
0.813 | 0.139 | -2 | 0.854 |
NEK7 |
0.812 | 0.030 | -3 | 0.817 |
IKKE |
0.812 | 0.012 | 1 | 0.760 |
ALK4 |
0.812 | 0.271 | -2 | 0.894 |
PIM3 |
0.812 | 0.065 | -3 | 0.790 |
TGFBR1 |
0.811 | 0.243 | -2 | 0.893 |
CHAK2 |
0.810 | 0.105 | -1 | 0.785 |
ACVR2B |
0.808 | 0.219 | -2 | 0.871 |
KIS |
0.808 | 0.054 | 1 | 0.569 |
MST4 |
0.808 | 0.103 | 2 | 0.749 |
ACVR2A |
0.808 | 0.208 | -2 | 0.865 |
MLK1 |
0.807 | 0.006 | 2 | 0.705 |
PLK1 |
0.806 | 0.101 | -2 | 0.866 |
ATM |
0.805 | 0.085 | 1 | 0.810 |
NDR2 |
0.805 | 0.007 | -3 | 0.788 |
ULK1 |
0.805 | -0.057 | -3 | 0.810 |
CAMK1B |
0.805 | -0.020 | -3 | 0.838 |
PDHK4 |
0.804 | -0.184 | 1 | 0.839 |
ALK2 |
0.804 | 0.237 | -2 | 0.882 |
GRK5 |
0.804 | -0.061 | -3 | 0.843 |
RSK2 |
0.804 | 0.056 | -3 | 0.733 |
NLK |
0.804 | -0.028 | 1 | 0.750 |
GRK6 |
0.803 | -0.001 | 1 | 0.841 |
CAMK2G |
0.803 | -0.070 | 2 | 0.654 |
BMPR1A |
0.803 | 0.254 | 1 | 0.776 |
IKKA |
0.803 | -0.002 | -2 | 0.711 |
NDR1 |
0.803 | 0.051 | -3 | 0.787 |
NEK9 |
0.802 | -0.002 | 2 | 0.733 |
NIK |
0.802 | 0.030 | -3 | 0.847 |
NUAK2 |
0.802 | 0.022 | -3 | 0.811 |
GRK7 |
0.802 | 0.100 | 1 | 0.788 |
PDHK1 |
0.802 | -0.120 | 1 | 0.826 |
WNK1 |
0.802 | 0.019 | -2 | 0.760 |
CDKL1 |
0.801 | 0.007 | -3 | 0.772 |
MLK3 |
0.801 | 0.056 | 2 | 0.660 |
TLK2 |
0.801 | 0.147 | 1 | 0.832 |
PIM1 |
0.801 | 0.091 | -3 | 0.748 |
GRK1 |
0.801 | 0.000 | -2 | 0.692 |
RSK3 |
0.801 | 0.040 | -3 | 0.727 |
PKN3 |
0.801 | -0.008 | -3 | 0.790 |
PKCD |
0.801 | 0.062 | 2 | 0.700 |
TTBK2 |
0.800 | -0.053 | 2 | 0.604 |
P70S6KB |
0.800 | 0.054 | -3 | 0.759 |
GRK4 |
0.800 | -0.031 | -2 | 0.770 |
HUNK |
0.799 | -0.057 | 2 | 0.662 |
SKMLCK |
0.799 | -0.007 | -2 | 0.773 |
ERK5 |
0.799 | -0.052 | 1 | 0.692 |
CAMLCK |
0.798 | 0.004 | -2 | 0.783 |
FAM20C |
0.798 | 0.015 | 2 | 0.435 |
PRKD1 |
0.798 | -0.011 | -3 | 0.762 |
MLK4 |
0.798 | 0.063 | 2 | 0.626 |
PKN2 |
0.798 | 0.007 | -3 | 0.798 |
HIPK4 |
0.797 | 0.032 | 1 | 0.725 |
PLK3 |
0.797 | 0.055 | 2 | 0.607 |
DAPK2 |
0.797 | -0.007 | -3 | 0.834 |
AMPKA1 |
0.797 | 0.018 | -3 | 0.810 |
P90RSK |
0.797 | 0.016 | -3 | 0.736 |
RIPK3 |
0.796 | -0.075 | 3 | 0.712 |
CHAK1 |
0.796 | 0.044 | 2 | 0.731 |
BCKDK |
0.796 | -0.080 | -1 | 0.826 |
ANKRD3 |
0.796 | -0.010 | 1 | 0.830 |
PRKD2 |
0.796 | 0.022 | -3 | 0.720 |
IRE1 |
0.796 | 0.010 | 1 | 0.792 |
LATS2 |
0.795 | -0.009 | -5 | 0.634 |
TLK1 |
0.795 | 0.132 | -2 | 0.857 |
PKCB |
0.795 | 0.057 | 2 | 0.663 |
AURC |
0.795 | 0.066 | -2 | 0.605 |
CDKL5 |
0.794 | 0.002 | -3 | 0.760 |
NIM1 |
0.794 | -0.001 | 3 | 0.761 |
IRE2 |
0.794 | 0.046 | 2 | 0.696 |
MARK4 |
0.794 | -0.026 | 4 | 0.799 |
SRPK1 |
0.794 | 0.030 | -3 | 0.717 |
DLK |
0.794 | -0.091 | 1 | 0.821 |
WNK3 |
0.793 | -0.126 | 1 | 0.825 |
MAPKAPK3 |
0.793 | -0.030 | -3 | 0.722 |
PKACG |
0.793 | 0.022 | -2 | 0.677 |
PKCG |
0.793 | 0.042 | 2 | 0.663 |
DNAPK |
0.793 | 0.096 | 1 | 0.782 |
YSK4 |
0.792 | -0.000 | 1 | 0.797 |
MAPKAPK2 |
0.792 | 0.002 | -3 | 0.680 |
PKR |
0.791 | 0.056 | 1 | 0.826 |
PHKG1 |
0.791 | 0.028 | -3 | 0.775 |
NUAK1 |
0.791 | 0.021 | -3 | 0.756 |
PERK |
0.791 | 0.081 | -2 | 0.843 |
NEK2 |
0.791 | 0.014 | 2 | 0.744 |
MLK2 |
0.791 | -0.064 | 2 | 0.711 |
PKCA |
0.790 | 0.044 | 2 | 0.667 |
AMPKA2 |
0.790 | 0.008 | -3 | 0.774 |
PAK1 |
0.790 | 0.013 | -2 | 0.700 |
PKCH |
0.790 | 0.029 | 2 | 0.657 |
RSK4 |
0.789 | 0.060 | -3 | 0.700 |
HRI |
0.789 | 0.043 | -2 | 0.850 |
PAK3 |
0.789 | -0.007 | -2 | 0.701 |
SRPK2 |
0.788 | 0.035 | -3 | 0.641 |
LATS1 |
0.788 | 0.025 | -3 | 0.797 |
PKACB |
0.788 | 0.069 | -2 | 0.628 |
MASTL |
0.788 | -0.220 | -2 | 0.747 |
ICK |
0.788 | -0.026 | -3 | 0.803 |
SMG1 |
0.788 | 0.020 | 1 | 0.806 |
CAMK2D |
0.787 | -0.096 | -3 | 0.795 |
PLK4 |
0.787 | -0.012 | 2 | 0.551 |
SRPK3 |
0.786 | 0.013 | -3 | 0.695 |
TSSK2 |
0.786 | -0.084 | -5 | 0.603 |
MNK2 |
0.786 | -0.012 | -2 | 0.730 |
GRK2 |
0.786 | 0.001 | -2 | 0.692 |
CLK1 |
0.786 | 0.051 | -3 | 0.719 |
CAMK2B |
0.786 | -0.030 | 2 | 0.586 |
MEK1 |
0.786 | -0.072 | 2 | 0.704 |
CLK4 |
0.786 | 0.038 | -3 | 0.741 |
PAK6 |
0.786 | 0.024 | -2 | 0.634 |
CAMK4 |
0.786 | -0.084 | -3 | 0.786 |
PIM2 |
0.785 | 0.098 | -3 | 0.714 |
AURA |
0.785 | 0.019 | -2 | 0.589 |
CLK2 |
0.784 | 0.080 | -3 | 0.715 |
AURB |
0.784 | 0.028 | -2 | 0.607 |
PKG2 |
0.784 | 0.036 | -2 | 0.618 |
MSK2 |
0.783 | -0.037 | -3 | 0.703 |
TSSK1 |
0.783 | -0.062 | -3 | 0.822 |
PKCZ |
0.783 | -0.017 | 2 | 0.706 |
MELK |
0.783 | -0.029 | -3 | 0.755 |
CDK8 |
0.783 | -0.059 | 1 | 0.546 |
PAK2 |
0.782 | -0.018 | -2 | 0.690 |
SGK3 |
0.782 | 0.034 | -3 | 0.718 |
RIPK1 |
0.782 | -0.182 | 1 | 0.815 |
CDK1 |
0.782 | 0.003 | 1 | 0.529 |
MST3 |
0.782 | 0.098 | 2 | 0.739 |
VRK2 |
0.782 | -0.138 | 1 | 0.829 |
PRKD3 |
0.782 | -0.022 | -3 | 0.708 |
MYLK4 |
0.781 | -0.007 | -2 | 0.702 |
ZAK |
0.781 | -0.005 | 1 | 0.774 |
TAO3 |
0.781 | 0.084 | 1 | 0.798 |
CDK5 |
0.781 | -0.002 | 1 | 0.586 |
CK1E |
0.781 | 0.017 | -3 | 0.594 |
AKT2 |
0.780 | 0.033 | -3 | 0.660 |
PHKG2 |
0.780 | 0.020 | -3 | 0.764 |
BRAF |
0.780 | 0.011 | -4 | 0.789 |
CAMK2A |
0.780 | -0.044 | 2 | 0.621 |
MNK1 |
0.780 | -0.012 | -2 | 0.738 |
PRKX |
0.780 | 0.067 | -3 | 0.643 |
MEKK2 |
0.780 | 0.004 | 2 | 0.690 |
NEK5 |
0.779 | 0.016 | 1 | 0.825 |
SIK |
0.779 | -0.010 | -3 | 0.721 |
DRAK1 |
0.779 | -0.030 | 1 | 0.759 |
DCAMKL1 |
0.779 | 0.024 | -3 | 0.738 |
QIK |
0.779 | -0.070 | -3 | 0.798 |
MEKK3 |
0.778 | -0.075 | 1 | 0.807 |
QSK |
0.778 | -0.033 | 4 | 0.780 |
SNRK |
0.778 | -0.107 | 2 | 0.614 |
PINK1 |
0.778 | -0.033 | 1 | 0.744 |
MEKK1 |
0.778 | -0.062 | 1 | 0.798 |
PLK2 |
0.777 | 0.065 | -3 | 0.827 |
CDK2 |
0.776 | -0.003 | 1 | 0.629 |
CDK19 |
0.776 | -0.057 | 1 | 0.508 |
CK1G1 |
0.776 | 0.013 | -3 | 0.587 |
DYRK2 |
0.776 | -0.054 | 1 | 0.617 |
CDK7 |
0.776 | -0.047 | 1 | 0.559 |
NEK8 |
0.775 | -0.004 | 2 | 0.732 |
MAPKAPK5 |
0.775 | -0.087 | -3 | 0.670 |
EEF2K |
0.775 | 0.085 | 3 | 0.839 |
GRK3 |
0.775 | -0.002 | -2 | 0.652 |
IRAK4 |
0.775 | -0.024 | 1 | 0.793 |
BRSK1 |
0.775 | -0.064 | -3 | 0.746 |
MSK1 |
0.775 | -0.027 | -3 | 0.705 |
MEK5 |
0.774 | -0.120 | 2 | 0.705 |
PKCT |
0.774 | 0.013 | 2 | 0.663 |
P38A |
0.774 | -0.035 | 1 | 0.586 |
CAMKK1 |
0.773 | -0.014 | -2 | 0.704 |
CDK18 |
0.773 | -0.015 | 1 | 0.493 |
MARK3 |
0.773 | -0.035 | 4 | 0.733 |
BRSK2 |
0.773 | -0.079 | -3 | 0.771 |
P38G |
0.772 | -0.025 | 1 | 0.440 |
TTBK1 |
0.772 | -0.106 | 2 | 0.537 |
MARK2 |
0.772 | -0.052 | 4 | 0.700 |
P70S6K |
0.772 | -0.004 | -3 | 0.671 |
CDK3 |
0.771 | 0.030 | 1 | 0.462 |
CK1D |
0.771 | 0.012 | -3 | 0.545 |
TNIK |
0.771 | 0.122 | 3 | 0.871 |
WNK4 |
0.771 | -0.089 | -2 | 0.745 |
TAO2 |
0.771 | 0.036 | 2 | 0.754 |
AKT1 |
0.771 | 0.027 | -3 | 0.669 |
CK1A2 |
0.771 | 0.015 | -3 | 0.546 |
JNK2 |
0.771 | -0.025 | 1 | 0.505 |
PKACA |
0.771 | 0.032 | -2 | 0.578 |
ERK1 |
0.770 | -0.046 | 1 | 0.499 |
DCAMKL2 |
0.770 | -0.022 | -3 | 0.771 |
JNK3 |
0.770 | -0.059 | 1 | 0.539 |
MST2 |
0.770 | 0.039 | 1 | 0.829 |
ERK7 |
0.770 | 0.034 | 2 | 0.533 |
CHK1 |
0.769 | -0.088 | -3 | 0.777 |
HIPK2 |
0.769 | -0.010 | 1 | 0.519 |
CDK13 |
0.769 | -0.080 | 1 | 0.537 |
CAMK1G |
0.769 | -0.057 | -3 | 0.728 |
SMMLCK |
0.769 | -0.033 | -3 | 0.787 |
HIPK1 |
0.769 | -0.018 | 1 | 0.626 |
CDK17 |
0.769 | -0.030 | 1 | 0.448 |
NEK4 |
0.769 | 0.019 | 1 | 0.810 |
P38B |
0.768 | -0.040 | 1 | 0.509 |
PRP4 |
0.768 | -0.041 | -3 | 0.712 |
PKCE |
0.767 | 0.037 | 2 | 0.664 |
PKCI |
0.767 | 0.009 | 2 | 0.687 |
GCK |
0.767 | 0.066 | 1 | 0.825 |
ERK2 |
0.767 | -0.074 | 1 | 0.565 |
CDK16 |
0.766 | 0.025 | 1 | 0.466 |
HGK |
0.766 | 0.059 | 3 | 0.859 |
MARK1 |
0.766 | -0.077 | 4 | 0.752 |
PASK |
0.766 | -0.031 | -3 | 0.812 |
GAK |
0.766 | 0.002 | 1 | 0.785 |
P38D |
0.766 | -0.017 | 1 | 0.450 |
MINK |
0.766 | 0.053 | 1 | 0.808 |
LKB1 |
0.766 | 0.040 | -3 | 0.789 |
PAK5 |
0.765 | -0.004 | -2 | 0.578 |
CK2A2 |
0.765 | 0.026 | 1 | 0.661 |
DAPK3 |
0.765 | 0.025 | -3 | 0.761 |
TTK |
0.765 | 0.161 | -2 | 0.867 |
DYRK1A |
0.764 | -0.042 | 1 | 0.637 |
HIPK3 |
0.764 | -0.041 | 1 | 0.627 |
GSK3B |
0.764 | -0.031 | 4 | 0.424 |
NEK11 |
0.764 | -0.113 | 1 | 0.789 |
GSK3A |
0.764 | -0.008 | 4 | 0.432 |
MRCKA |
0.764 | 0.106 | -3 | 0.716 |
CAMKK2 |
0.763 | -0.066 | -2 | 0.702 |
TAK1 |
0.763 | -0.003 | 1 | 0.823 |
CDK14 |
0.762 | -0.025 | 1 | 0.545 |
LOK |
0.762 | 0.053 | -2 | 0.707 |
MPSK1 |
0.762 | -0.028 | 1 | 0.721 |
NEK1 |
0.762 | 0.028 | 1 | 0.807 |
CDK12 |
0.762 | -0.083 | 1 | 0.511 |
MST1 |
0.762 | 0.042 | 1 | 0.815 |
HPK1 |
0.762 | 0.059 | 1 | 0.814 |
CDK9 |
0.762 | -0.089 | 1 | 0.547 |
AKT3 |
0.761 | 0.038 | -3 | 0.591 |
SSTK |
0.761 | -0.086 | 4 | 0.764 |
IRAK1 |
0.761 | -0.167 | -1 | 0.731 |
PAK4 |
0.760 | -0.019 | -2 | 0.593 |
MRCKB |
0.760 | 0.062 | -3 | 0.703 |
MEKK6 |
0.760 | -0.037 | 1 | 0.804 |
VRK1 |
0.760 | -0.064 | 2 | 0.728 |
PDK1 |
0.760 | -0.090 | 1 | 0.755 |
MAP3K15 |
0.760 | -0.063 | 1 | 0.766 |
KHS2 |
0.760 | 0.099 | 1 | 0.820 |
SGK1 |
0.759 | 0.046 | -3 | 0.577 |
DAPK1 |
0.759 | 0.004 | -3 | 0.750 |
CAMK1D |
0.759 | -0.040 | -3 | 0.654 |
OSR1 |
0.759 | 0.072 | 2 | 0.686 |
ROCK2 |
0.758 | 0.078 | -3 | 0.744 |
YSK1 |
0.758 | 0.035 | 2 | 0.725 |
KHS1 |
0.758 | 0.070 | 1 | 0.810 |
PKN1 |
0.758 | -0.023 | -3 | 0.689 |
DYRK1B |
0.757 | -0.046 | 1 | 0.566 |
DYRK3 |
0.757 | -0.037 | 1 | 0.639 |
CDK10 |
0.757 | -0.006 | 1 | 0.524 |
SLK |
0.757 | 0.007 | -2 | 0.659 |
LRRK2 |
0.755 | -0.084 | 2 | 0.754 |
CK2A1 |
0.755 | 0.007 | 1 | 0.643 |
CHK2 |
0.754 | -0.019 | -3 | 0.605 |
CDK6 |
0.754 | -0.020 | 1 | 0.515 |
STK33 |
0.753 | -0.093 | 2 | 0.518 |
MEK2 |
0.753 | -0.103 | 2 | 0.700 |
DYRK4 |
0.753 | -0.070 | 1 | 0.523 |
BUB1 |
0.752 | 0.026 | -5 | 0.567 |
PDHK3_TYR |
0.752 | 0.057 | 4 | 0.845 |
JNK1 |
0.751 | -0.063 | 1 | 0.499 |
MAP2K4_TYR |
0.750 | 0.030 | -1 | 0.882 |
MYO3A |
0.750 | 0.069 | 1 | 0.813 |
EPHA6 |
0.750 | 0.084 | -1 | 0.889 |
MAP2K6_TYR |
0.749 | 0.023 | -1 | 0.876 |
ROCK1 |
0.749 | 0.061 | -3 | 0.711 |
MYO3B |
0.748 | 0.054 | 2 | 0.760 |
EPHB4 |
0.747 | 0.060 | -1 | 0.885 |
DMPK1 |
0.747 | 0.070 | -3 | 0.727 |
RIPK2 |
0.747 | -0.195 | 1 | 0.729 |
PINK1_TYR |
0.746 | 0.012 | 1 | 0.808 |
TESK1_TYR |
0.746 | 0.017 | 3 | 0.884 |
CDK4 |
0.746 | -0.044 | 1 | 0.500 |
ABL2 |
0.746 | 0.099 | -1 | 0.835 |
BMPR2_TYR |
0.746 | -0.002 | -1 | 0.870 |
PDHK1_TYR |
0.746 | -0.010 | -1 | 0.879 |
CAMK1A |
0.746 | -0.055 | -3 | 0.619 |
PDHK4_TYR |
0.745 | -0.014 | 2 | 0.725 |
MAP2K7_TYR |
0.745 | -0.088 | 2 | 0.729 |
RET |
0.745 | 0.052 | 1 | 0.806 |
TYK2 |
0.745 | 0.042 | 1 | 0.807 |
PBK |
0.744 | -0.015 | 1 | 0.707 |
NEK3 |
0.744 | -0.080 | 1 | 0.750 |
CK1A |
0.744 | -0.000 | -3 | 0.461 |
PKMYT1_TYR |
0.743 | -0.022 | 3 | 0.850 |
MAK |
0.743 | -0.004 | -2 | 0.682 |
TXK |
0.743 | 0.115 | 1 | 0.791 |
TAO1 |
0.743 | 0.010 | 1 | 0.744 |
MOK |
0.743 | -0.003 | 1 | 0.650 |
ROS1 |
0.743 | 0.050 | 3 | 0.766 |
ALPHAK3 |
0.742 | 0.007 | -1 | 0.800 |
YES1 |
0.742 | 0.064 | -1 | 0.840 |
LIMK2_TYR |
0.741 | 0.050 | -3 | 0.840 |
CSF1R |
0.741 | 0.032 | 3 | 0.770 |
ABL1 |
0.741 | 0.061 | -1 | 0.827 |
TYRO3 |
0.740 | 0.010 | 3 | 0.797 |
PKG1 |
0.740 | -0.029 | -2 | 0.535 |
FER |
0.740 | 0.029 | 1 | 0.841 |
INSRR |
0.740 | 0.053 | 3 | 0.734 |
JAK2 |
0.739 | -0.004 | 1 | 0.787 |
ASK1 |
0.739 | -0.078 | 1 | 0.751 |
LCK |
0.739 | 0.094 | -1 | 0.835 |
HCK |
0.738 | 0.042 | -1 | 0.839 |
BLK |
0.737 | 0.101 | -1 | 0.841 |
MST1R |
0.737 | -0.035 | 3 | 0.796 |
EPHB1 |
0.737 | 0.027 | 1 | 0.835 |
YANK3 |
0.737 | -0.060 | 2 | 0.306 |
EPHB2 |
0.737 | 0.046 | -1 | 0.867 |
EPHB3 |
0.736 | 0.029 | -1 | 0.879 |
FGR |
0.736 | -0.003 | 1 | 0.807 |
JAK3 |
0.736 | 0.006 | 1 | 0.781 |
CRIK |
0.736 | 0.003 | -3 | 0.667 |
JAK1 |
0.736 | 0.065 | 1 | 0.767 |
TEC |
0.736 | 0.074 | -1 | 0.784 |
FLT3 |
0.735 | 0.021 | 3 | 0.786 |
LIMK1_TYR |
0.734 | -0.092 | 2 | 0.754 |
KIT |
0.734 | 0.006 | 3 | 0.777 |
EPHA4 |
0.734 | -0.008 | 2 | 0.606 |
KDR |
0.733 | 0.023 | 3 | 0.736 |
ITK |
0.733 | 0.012 | -1 | 0.815 |
BMX |
0.733 | 0.036 | -1 | 0.765 |
SRMS |
0.733 | -0.008 | 1 | 0.839 |
ALK |
0.732 | 0.021 | 3 | 0.711 |
BIKE |
0.732 | -0.031 | 1 | 0.654 |
PTK6 |
0.732 | 0.006 | -1 | 0.761 |
HASPIN |
0.732 | -0.062 | -1 | 0.611 |
PDGFRB |
0.731 | -0.047 | 3 | 0.793 |
SBK |
0.731 | -0.054 | -3 | 0.541 |
DDR1 |
0.731 | -0.094 | 4 | 0.772 |
MERTK |
0.731 | 0.003 | 3 | 0.760 |
STLK3 |
0.731 | -0.084 | 1 | 0.758 |
FYN |
0.730 | 0.051 | -1 | 0.812 |
FRK |
0.730 | 0.039 | -1 | 0.851 |
FGFR2 |
0.730 | -0.027 | 3 | 0.775 |
BTK |
0.729 | -0.024 | -1 | 0.777 |
MET |
0.729 | 0.007 | 3 | 0.770 |
LTK |
0.729 | -0.007 | 3 | 0.737 |
NEK10_TYR |
0.729 | 0.017 | 1 | 0.687 |
TNNI3K_TYR |
0.728 | 0.026 | 1 | 0.745 |
FLT1 |
0.727 | -0.014 | -1 | 0.846 |
WEE1_TYR |
0.727 | -0.004 | -1 | 0.764 |
EPHA7 |
0.727 | -0.011 | 2 | 0.622 |
ERBB2 |
0.725 | -0.039 | 1 | 0.784 |
PDGFRA |
0.725 | -0.080 | 3 | 0.792 |
NTRK1 |
0.725 | -0.076 | -1 | 0.850 |
TNK2 |
0.725 | -0.044 | 3 | 0.742 |
AXL |
0.724 | -0.057 | 3 | 0.756 |
INSR |
0.724 | -0.026 | 3 | 0.716 |
TEK |
0.723 | -0.060 | 3 | 0.736 |
LYN |
0.723 | 0.004 | 3 | 0.707 |
EPHA5 |
0.723 | 0.003 | 2 | 0.585 |
FGFR1 |
0.723 | -0.074 | 3 | 0.753 |
EPHA1 |
0.722 | -0.024 | 3 | 0.749 |
TNK1 |
0.722 | -0.050 | 3 | 0.777 |
EPHA8 |
0.722 | 0.007 | -1 | 0.853 |
NTRK2 |
0.721 | -0.061 | 3 | 0.729 |
EPHA3 |
0.721 | -0.073 | 2 | 0.592 |
FGFR3 |
0.721 | -0.041 | 3 | 0.747 |
NTRK3 |
0.720 | -0.044 | -1 | 0.818 |
FLT4 |
0.720 | -0.069 | 3 | 0.738 |
MATK |
0.720 | -0.020 | -1 | 0.752 |
CK1G3 |
0.719 | -0.013 | -3 | 0.416 |
SRC |
0.719 | -0.007 | -1 | 0.818 |
SYK |
0.718 | 0.029 | -1 | 0.805 |
EGFR |
0.718 | -0.017 | 1 | 0.691 |
PTK2B |
0.717 | -0.018 | -1 | 0.810 |
FGFR4 |
0.716 | -0.022 | -1 | 0.810 |
CSK |
0.715 | -0.062 | 2 | 0.625 |
AAK1 |
0.714 | -0.008 | 1 | 0.543 |
IGF1R |
0.714 | -0.020 | 3 | 0.661 |
PTK2 |
0.713 | 0.001 | -1 | 0.800 |
MUSK |
0.713 | -0.040 | 1 | 0.699 |
YANK2 |
0.711 | -0.056 | 2 | 0.313 |
DDR2 |
0.711 | -0.048 | 3 | 0.716 |
EPHA2 |
0.711 | -0.025 | -1 | 0.827 |
CK1G2 |
0.706 | -0.014 | -3 | 0.506 |
ERBB4 |
0.704 | -0.019 | 1 | 0.706 |
ZAP70 |
0.702 | 0.018 | -1 | 0.737 |
FES |
0.699 | -0.056 | -1 | 0.748 |