Motif 651 (n=159)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S62 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A0A0J9YX86 | GOLGA8Q | S383 | ochoa | Golgin A8 family member Q | None |
| A0A0M3HER8 | GOLGA6L10 | S444 | ochoa | Golgin A6 family like 10 | None |
| A6NEF3 | GOLGA6L4 | S482 | ochoa | Golgin subfamily A member 6-like protein 4 | None |
| A6NEM1 | GOLGA6L9 | S340 | ochoa | Golgin subfamily A member 6-like protein 9 | None |
| A6NI86 | GOLGA6L10 | S430 | ochoa | Golgin subfamily A member 6-like protein 10 | None |
| H0YKK7 | GOLGA6L19 | S458 | ochoa | Putative golgin subfamily A member 6-like protein 19 | None |
| H3BSY2 | GOLGA8M | S383 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S382 | ochoa | Golgin subfamily A member 8R | None |
| O14646 | CHD1 | S1040 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O15085 | ARHGEF11 | S1135 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43491 | EPB41L2 | S647 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60524 | NEMF | S748 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60669 | SLC16A7 | S457 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O75112 | LDB3 | S267 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75363 | BCAS1 | S234 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75554 | WBP4 | S227 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O95164 | UBL3 | S31 | ochoa | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | None |
| P05060 | CHGB | S320 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P09661 | SNRPA1 | S226 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P11021 | HSPA5 | S301 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11021 | HSPA5 | S632 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11137 | MAP2 | S1021 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11142 | HSPA8 | S538 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11171 | EPB41 | S684 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P34932 | HSPA4 | S777 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35659 | DEK | S244 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35749 | MYH11 | S1719 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S889 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46087 | NOP2 | S198 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P47710 | CSN1S1 | S89 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P49321 | NASP | S610 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P54920 | NAPA | S24 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55895 | RAG2 | S365 | psp | V(D)J recombination-activating protein 2 (RAG-2) | Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). {ECO:0000250}. |
| P60709 | ACTB | S234 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S236 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S234 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S235 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S236 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S236 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78316 | NOP14 | S133 | ochoa | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| P78559 | MAP1A | S921 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P83916 | CBX1 | S128 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| Q01118 | SCN7A | S791 | ochoa | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (PubMed:26537257). {ECO:0000250|UniProtKB:B1AYL1, ECO:0000269|PubMed:26537257, ECO:0000269|PubMed:35301303}. |
| Q04721 | NOTCH2 | S1855 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q12872 | SFSWAP | S617 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13017 | ARHGAP5 | S1115 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13185 | CBX3 | S132 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13547 | HDAC1 | S406 | ochoa|psp | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q13563 | PKD2 | S795 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q13829 | TNFAIP1 | S265 | psp | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}. |
| Q14126 | DSG2 | S701 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14562 | DHX8 | S395 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14966 | ZNF638 | S1158 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14D04 | VEPH1 | S476 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15047 | SETDB1 | S878 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15303 | ERBB4 | S1129 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15910 | EZH2 | S406 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q27J81 | INF2 | S1158 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2NKX8 | ERCC6L | S1041 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2NKX8 | ERCC6L | S1152 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q49AR2 | C5orf22 | S198 | ochoa | UPF0489 protein C5orf22 | None |
| Q562E7 | WDR81 | S1135 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q562R1 | ACTBL2 | S235 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q5F1R6 | DNAJC21 | S436 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5H9S7 | DCAF17 | S404 | ochoa | DDB1- and CUL4-associated factor 17 | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
| Q5JTV8 | TOR1AIP1 | S169 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5THJ4 | VPS13D | S1712 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1926 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q6IN85 | PPP4R3A | S126 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IQ55 | TTBK2 | S786 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6P9G4 | TMEM154 | S117 | ochoa | Transmembrane protein 154 | None |
| Q6S8J3 | POTEE | S934 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6UN15 | FIP1L1 | S62 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6WKZ4 | RAB11FIP1 | S685 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZMS4 | ZNF852 | S145 | ochoa | Zinc finger protein 852 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q7L590 | MCM10 | S95 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z591 | AKNA | S52 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5K2 | WAPL | S257 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q86Y56 | DNAAF5 | S837 | ochoa | Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) | Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. |
| Q8IV38 | ANKMY2 | S422 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8IWE2 | FAM114A1 | S36 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IY92 | SLX4 | S1172 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N302 | AGGF1 | S351 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N7H5 | PAF1 | S117 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
| Q8N9T8 | KRI1 | S182 | ochoa | Protein KRI1 homolog | None |
| Q8NDI1 | EHBP1 | S295 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFG4 | FLCN | S302 | ochoa | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8NI35 | PATJ | S805 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TAQ2 | SMARCC2 | S806 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TDY2 | RB1CC1 | S1221 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WUA2 | PPIL4 | S188 | ochoa | Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}. |
| Q8WUY3 | PRUNE2 | S576 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92766 | RREB1 | S1320 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92793 | CREBBP | S1043 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92844 | TANK | S129 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q969Z0 | TBRG4 | S64 | ochoa | FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) | Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}. |
| Q96C24 | SYTL4 | S289 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96L93 | KIF16B | S881 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96QE3 | ATAD5 | S369 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96RL7 | VPS13A | S849 | ochoa | Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:34830155}. |
| Q96ST2 | IWS1 | T67 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S80 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S157 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S170 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S196 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S209 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S222 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S235 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S248 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S261 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S287 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S300 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96T17 | MAP7D2 | S650 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99661 | KIF2C | S633 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q9BS40 | LXN | S41 | ochoa | Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Protein MUM) (Tissue carboxypeptidase inhibitor) (TCI) | Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. {ECO:0000269|PubMed:15738388}. |
| Q9BVS4 | RIOK2 | S335 | ochoa|psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BY43 | CHMP4A | S193 | ochoa | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}. |
| Q9C0G0 | ZNF407 | S952 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9GZY6 | LAT2 | S196 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H098 | FAM107B | S78 | ochoa | Protein FAM107B | None |
| Q9H2P0 | ADNP | S891 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9HAU0 | PLEKHA5 | S410 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HAW4 | CLSPN | S30 | psp | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HCH5 | SYTL2 | S322 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NTJ3 | SMC4 | S41 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NUQ6 | SPATS2L | S120 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVU7 | SDAD1 | S595 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NVW2 | RLIM | S163 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NW68 | BSDC1 | S388 | ochoa | BSD domain-containing protein 1 | None |
| Q9NW97 | TMEM51 | S143 | ochoa | Transmembrane protein 51 | None |
| Q9NY27 | PPP4R2 | S216 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NY72 | SCN3B | S196 | ochoa | Sodium channel regulatory subunit beta-3 | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:20558140, PubMed:21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed:20558140, PubMed:21051419, PubMed:24567321, PubMed:31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed:35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed:14975698). {ECO:0000250|UniProtKB:Q9JK00, ECO:0000269|PubMed:14975698, ECO:0000269|PubMed:20558140, ECO:0000269|PubMed:21051419, ECO:0000269|PubMed:24567321, ECO:0000269|PubMed:31950564, ECO:0000269|PubMed:35301303}. |
| Q9NYF8 | BCLAF1 | S183 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S414 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZ63 | C9orf78 | S156 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9NZM3 | ITSN2 | S571 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P2N2 | ARHGAP28 | S65 | ochoa | Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UDV7 | ZNF282 | S315 | ochoa | Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) | Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. |
| Q9UEY8 | ADD3 | S590 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UGP4 | LIMD1 | S24 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHY8 | FEZ2 | S219 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UIL8 | PHF11 | S254 | ochoa | PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34) | Positive regulator of Th1-type cytokine gene expression. {ECO:0000269|PubMed:18405956}. |
| Q9UJK0 | TSR3 | S228 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
| Q9UL54 | TAOK2 | S414 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9UNE0 | EDAR | S283 | ochoa | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
| Q9UNY4 | TTF2 | S364 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9Y2M0 | FAN1 | S210 | ochoa | Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}. |
| Q9Y3S2 | ZNF330 | S291 | ochoa | Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) | None |
| Q9Y3T9 | NOC2L | S26 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4W6 | AFG3L2 | S765 | ochoa | Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) | Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:19748354, PubMed:28396416, PubMed:29932645, PubMed:30683687, PubMed:31327635, PubMed:37917749, PubMed:38157846). AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354, PubMed:31327635). The m-AAA protease carries out quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:26504172, PubMed:30683687, PubMed:34718584). The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7 (PubMed:22354088, PubMed:29932645, PubMed:30252181). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:29932645). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (PubMed:30252181). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048, PubMed:28396416). Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435). Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39 (PubMed:37917749, PubMed:38157846). SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur (PubMed:37917749, PubMed:38157846). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:17615298, PubMed:29545505, PubMed:30252181, PubMed:30683687, PubMed:32600459). May act by mediating processing of OMA1 precursor, participating in OMA1 maturation (PubMed:29545505). {ECO:0000269|PubMed:17615298, ECO:0000269|PubMed:19748354, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:26504172, ECO:0000269|PubMed:27642048, ECO:0000269|PubMed:28396416, ECO:0000269|PubMed:29545505, ECO:0000269|PubMed:29932645, ECO:0000269|PubMed:30252181, ECO:0000269|PubMed:30683687, ECO:0000269|PubMed:31327635, ECO:0000269|PubMed:32600459, ECO:0000269|PubMed:34718584, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}. |
| Q9Y6Y8 | SEC23IP | S895 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q8WVM8 | SCFD1 | S347 | Sugiyama | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| P52907 | CAPZA1 | S119 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P13073 | COX4I1 | S74 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P51957 | NEK4 | S404 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q5S007 | LRRK2 | S1467 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P41252 | IARS1 | S827 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| Q9UK32 | RPS6KA6 | S24 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.000003 | 5.471 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.000240 | 3.621 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000249 | 3.603 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.000078 | 4.109 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.000189 | 3.725 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.000240 | 3.620 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.000240 | 3.620 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.000289 | 3.540 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.000462 | 3.335 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.000541 | 3.267 |
| R-HSA-421270 | Cell-cell junction organization | 0.000706 | 3.151 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.000994 | 3.003 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.001160 | 2.936 |
| R-HSA-418990 | Adherens junctions interactions | 0.001098 | 2.959 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.001542 | 2.812 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.001695 | 2.771 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.001665 | 2.779 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.001542 | 2.812 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.001568 | 2.805 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.001353 | 2.869 |
| R-HSA-446728 | Cell junction organization | 0.001432 | 2.844 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.001935 | 2.713 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.002437 | 2.613 |
| R-HSA-373760 | L1CAM interactions | 0.002839 | 2.547 |
| R-HSA-1500931 | Cell-Cell communication | 0.003382 | 2.471 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.003691 | 2.433 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.004194 | 2.377 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.004264 | 2.370 |
| R-HSA-9620244 | Long-term potentiation | 0.004592 | 2.338 |
| R-HSA-196025 | Formation of annular gap junctions | 0.006282 | 2.202 |
| R-HSA-190873 | Gap junction degradation | 0.007425 | 2.129 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.006408 | 2.193 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.006258 | 2.204 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.006920 | 2.160 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.006408 | 2.193 |
| R-HSA-157118 | Signaling by NOTCH | 0.006994 | 2.155 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.006282 | 2.202 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.006920 | 2.160 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.006920 | 2.160 |
| R-HSA-8848021 | Signaling by PTK6 | 0.007258 | 2.139 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.007258 | 2.139 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.007490 | 2.126 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.007981 | 2.098 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.009545 | 2.020 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.011363 | 1.945 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.011814 | 1.928 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.011576 | 1.936 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.011363 | 1.945 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.011814 | 1.928 |
| R-HSA-397014 | Muscle contraction | 0.012530 | 1.902 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.012801 | 1.893 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.014395 | 1.842 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.014154 | 1.849 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.014395 | 1.842 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.016027 | 1.795 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.017735 | 1.751 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.019388 | 1.712 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.018135 | 1.741 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.017735 | 1.751 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.017735 | 1.751 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.019533 | 1.709 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.019827 | 1.703 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.019827 | 1.703 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.021016 | 1.677 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.021016 | 1.677 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.023292 | 1.633 |
| R-HSA-437239 | Recycling pathway of L1 | 0.021339 | 1.671 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.022606 | 1.646 |
| R-HSA-8939211 | ESR-mediated signaling | 0.020664 | 1.685 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.023394 | 1.631 |
| R-HSA-4839726 | Chromatin organization | 0.025647 | 1.591 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.027039 | 1.568 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.027815 | 1.556 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.029466 | 1.531 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.029466 | 1.531 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.043537 | 1.361 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.043487 | 1.362 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.043487 | 1.362 |
| R-HSA-72172 | mRNA Splicing | 0.033328 | 1.477 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.036543 | 1.437 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.036543 | 1.437 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.036543 | 1.437 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.036543 | 1.437 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.041555 | 1.381 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.036543 | 1.437 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.036707 | 1.435 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.040665 | 1.391 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.036543 | 1.437 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.036543 | 1.437 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.043487 | 1.362 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 0.041592 | 1.381 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.036543 | 1.437 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.033216 | 1.479 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.045204 | 1.345 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.046023 | 1.337 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.046299 | 1.334 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.048032 | 1.318 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.051719 | 1.286 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.061739 | 1.209 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.061739 | 1.209 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.071653 | 1.145 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.100777 | 0.997 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.100777 | 0.997 |
| R-HSA-444257 | RSK activation | 0.110282 | 0.957 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.110282 | 0.957 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.119686 | 0.922 |
| R-HSA-9613354 | Lipophagy | 0.119686 | 0.922 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.128992 | 0.889 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.128992 | 0.889 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.147312 | 0.832 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.147312 | 0.832 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.147312 | 0.832 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.156327 | 0.806 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.053946 | 1.268 |
| R-HSA-390522 | Striated Muscle Contraction | 0.068114 | 1.167 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.191452 | 0.718 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.200003 | 0.699 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.225122 | 0.648 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.225122 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.233319 | 0.632 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.233319 | 0.632 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.233319 | 0.632 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.233319 | 0.632 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.137640 | 0.861 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.241430 | 0.617 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.165248 | 0.782 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.233319 | 0.632 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.080224 | 1.096 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.069977 | 1.155 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.200003 | 0.699 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.147312 | 0.832 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.200003 | 0.699 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.156327 | 0.806 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.068114 | 1.167 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.091172 | 1.040 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.065190 | 1.186 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.080224 | 1.096 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.096207 | 1.017 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.174088 | 0.759 |
| R-HSA-8949664 | Processing of SMDT1 | 0.165248 | 0.782 |
| R-HSA-3371568 | Attenuation phase | 0.089709 | 1.047 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.189755 | 0.722 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.147312 | 0.832 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.096207 | 1.017 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.113001 | 0.947 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.113001 | 0.947 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.113001 | 0.947 |
| R-HSA-5693538 | Homology Directed Repair | 0.053176 | 1.274 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.051150 | 1.291 |
| R-HSA-68877 | Mitotic Prometaphase | 0.189819 | 0.722 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.077497 | 1.111 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.093663 | 1.028 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.179260 | 0.747 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.051719 | 1.286 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.147312 | 0.832 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.147312 | 0.832 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.051254 | 1.290 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.191452 | 0.718 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.130482 | 0.884 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.134050 | 0.873 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.137640 | 0.861 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.182138 | 0.740 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.119892 | 0.921 |
| R-HSA-9843745 | Adipogenesis | 0.072652 | 1.139 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.216837 | 0.664 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.156327 | 0.806 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.113001 | 0.947 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.110282 | 0.957 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.051150 | 1.291 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.205113 | 0.688 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.193581 | 0.713 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.144883 | 0.839 |
| R-HSA-3371556 | Cellular response to heat stress | 0.056812 | 1.246 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.236513 | 0.626 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.106392 | 0.973 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.089709 | 1.047 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.089709 | 1.047 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.216720 | 0.664 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.128992 | 0.889 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.074064 | 1.130 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.100143 | 0.999 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.233714 | 0.631 |
| R-HSA-9664407 | Parasite infection | 0.233714 | 0.631 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.233714 | 0.631 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.061074 | 1.214 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.119918 | 0.921 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.091172 | 1.040 |
| R-HSA-4641265 | Repression of WNT target genes | 0.156327 | 0.806 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.137640 | 0.861 |
| R-HSA-68882 | Mitotic Anaphase | 0.242944 | 0.614 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.200003 | 0.699 |
| R-HSA-199991 | Membrane Trafficking | 0.101515 | 0.993 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.061739 | 1.209 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.119686 | 0.922 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.128992 | 0.889 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.147312 | 0.832 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.156327 | 0.806 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 0.182809 | 0.738 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.191452 | 0.718 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.054364 | 1.265 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.134050 | 0.873 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.240090 | 0.620 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.204923 | 0.688 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.065190 | 1.186 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.185941 | 0.731 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.209303 | 0.679 |
| R-HSA-983189 | Kinesins | 0.163316 | 0.787 |
| R-HSA-69481 | G2/M Checkpoints | 0.192591 | 0.715 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.071653 | 1.145 |
| R-HSA-447041 | CHL1 interactions | 0.100777 | 0.997 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.156327 | 0.806 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.156327 | 0.806 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.156327 | 0.806 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.174075 | 0.759 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.216837 | 0.664 |
| R-HSA-190828 | Gap junction trafficking | 0.106194 | 0.974 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.061074 | 1.214 |
| R-HSA-1632852 | Macroautophagy | 0.236513 | 0.626 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.064568 | 1.190 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.200003 | 0.699 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.208465 | 0.681 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.099505 | 1.002 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.123415 | 0.909 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.136391 | 0.865 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.052745 | 1.278 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.208975 | 0.680 |
| R-HSA-9659379 | Sensory processing of sound | 0.066349 | 1.178 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.155891 | 0.807 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.174075 | 0.759 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.064568 | 1.190 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.175238 | 0.756 |
| R-HSA-8953854 | Metabolism of RNA | 0.124879 | 0.904 |
| R-HSA-73894 | DNA Repair | 0.111884 | 0.951 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.092941 | 1.032 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.241430 | 0.617 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.109583 | 0.960 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.212844 | 0.672 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.148534 | 0.828 |
| R-HSA-8852135 | Protein ubiquitination | 0.220602 | 0.656 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.232735 | 0.633 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.241430 | 0.617 |
| R-HSA-8876725 | Protein methylation | 0.182809 | 0.738 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.068114 | 1.167 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.116446 | 0.934 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.113064 | 0.947 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.134050 | 0.873 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.061090 | 1.214 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.110282 | 0.957 |
| R-HSA-210991 | Basigin interactions | 0.241430 | 0.617 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.233541 | 0.632 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.097841 | 1.009 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.051150 | 1.291 |
| R-HSA-162582 | Signal Transduction | 0.158550 | 0.800 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.233319 | 0.632 |
| R-HSA-373755 | Semaphorin interactions | 0.174568 | 0.758 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.065190 | 1.186 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.065190 | 1.186 |
| R-HSA-6807070 | PTEN Regulation | 0.230922 | 0.637 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.096207 | 1.017 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.233847 | 0.631 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.095634 | 1.019 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.062310 | 1.205 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.122575 | 0.912 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.115270 | 0.938 |
| R-HSA-9675108 | Nervous system development | 0.193495 | 0.713 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.147558 | 0.831 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.187691 | 0.727 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.113064 | 0.947 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.106194 | 0.974 |
| R-HSA-75153 | Apoptotic execution phase | 0.113001 | 0.947 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.216837 | 0.664 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.158661 | 0.800 |
| R-HSA-201556 | Signaling by ALK | 0.086511 | 1.063 |
| R-HSA-194138 | Signaling by VEGF | 0.187254 | 0.728 |
| R-HSA-1474244 | Extracellular matrix organization | 0.171795 | 0.765 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.244452 | 0.612 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.245231 | 0.610 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.246420 | 0.608 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.249456 | 0.603 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.249456 | 0.603 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.249456 | 0.603 |
| R-HSA-449147 | Signaling by Interleukins | 0.249817 | 0.602 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.251825 | 0.599 |
| R-HSA-422475 | Axon guidance | 0.254979 | 0.593 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.257398 | 0.589 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.259658 | 0.586 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.259658 | 0.586 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.263576 | 0.579 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.263576 | 0.579 |
| R-HSA-112316 | Neuronal System | 0.264600 | 0.577 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.265256 | 0.576 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.267221 | 0.573 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.267494 | 0.573 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.273031 | 0.564 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.273031 | 0.564 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.273031 | 0.564 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.273031 | 0.564 |
| R-HSA-73887 | Death Receptor Signaling | 0.276229 | 0.559 |
| R-HSA-72312 | rRNA processing | 0.280060 | 0.553 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.280724 | 0.552 |
| R-HSA-420029 | Tight junction interactions | 0.280724 | 0.552 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.280724 | 0.552 |
| R-HSA-9612973 | Autophagy | 0.281965 | 0.550 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.287074 | 0.542 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.288337 | 0.540 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.288337 | 0.540 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.295869 | 0.529 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.295869 | 0.529 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.300929 | 0.522 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.302701 | 0.519 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.302701 | 0.519 |
| R-HSA-5620971 | Pyroptosis | 0.303322 | 0.518 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.305003 | 0.516 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.306599 | 0.513 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.310697 | 0.508 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.310697 | 0.508 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.314384 | 0.503 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.314384 | 0.503 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.317994 | 0.498 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.317994 | 0.498 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.317994 | 0.498 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.317994 | 0.498 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.325214 | 0.488 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.325214 | 0.488 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.325214 | 0.488 |
| R-HSA-3214847 | HATs acetylate histones | 0.326024 | 0.487 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.329893 | 0.482 |
| R-HSA-1538133 | G0 and Early G1 | 0.332359 | 0.478 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.332359 | 0.478 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.336795 | 0.473 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.337613 | 0.472 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.339428 | 0.469 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.339428 | 0.469 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.339428 | 0.469 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.339428 | 0.469 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.340387 | 0.468 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.346422 | 0.460 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.346422 | 0.460 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.346422 | 0.460 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.349142 | 0.457 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.349142 | 0.457 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.353343 | 0.452 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.353343 | 0.452 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.353343 | 0.452 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.353343 | 0.452 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.353343 | 0.452 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.353343 | 0.452 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.353343 | 0.452 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.360192 | 0.443 |
| R-HSA-381042 | PERK regulates gene expression | 0.360192 | 0.443 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.366968 | 0.435 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.366968 | 0.435 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.366968 | 0.435 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.366968 | 0.435 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.368205 | 0.434 |
| R-HSA-1640170 | Cell Cycle | 0.370532 | 0.431 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.373672 | 0.428 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.373672 | 0.428 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.380306 | 0.420 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.386871 | 0.412 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.386871 | 0.412 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.386871 | 0.412 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.393366 | 0.405 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.406152 | 0.391 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.409333 | 0.388 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.412444 | 0.385 |
| R-HSA-9710421 | Defective pyroptosis | 0.418669 | 0.378 |
| R-HSA-2262752 | Cellular responses to stress | 0.424797 | 0.372 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.424829 | 0.372 |
| R-HSA-5683826 | Surfactant metabolism | 0.424829 | 0.372 |
| R-HSA-68886 | M Phase | 0.426279 | 0.370 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.427601 | 0.369 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.427601 | 0.369 |
| R-HSA-5357801 | Programmed Cell Death | 0.428210 | 0.368 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.431818 | 0.365 |
| R-HSA-1266738 | Developmental Biology | 0.432794 | 0.364 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.436956 | 0.360 |
| R-HSA-9675135 | Diseases of DNA repair | 0.436956 | 0.360 |
| R-HSA-69206 | G1/S Transition | 0.438420 | 0.358 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.442923 | 0.354 |
| R-HSA-114608 | Platelet degranulation | 0.445572 | 0.351 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.448828 | 0.348 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.456204 | 0.341 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.458622 | 0.339 |
| R-HSA-5576891 | Cardiac conduction | 0.463227 | 0.334 |
| R-HSA-9864848 | Complex IV assembly | 0.466171 | 0.331 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.466171 | 0.331 |
| R-HSA-912446 | Meiotic recombination | 0.466171 | 0.331 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.470197 | 0.328 |
| R-HSA-72187 | mRNA 3'-end processing | 0.471831 | 0.326 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.471831 | 0.326 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.471831 | 0.326 |
| R-HSA-1221632 | Meiotic synapsis | 0.477431 | 0.321 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.477431 | 0.321 |
| R-HSA-109582 | Hemostasis | 0.485465 | 0.314 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.485836 | 0.314 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.487384 | 0.312 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.488454 | 0.311 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.488454 | 0.311 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.493879 | 0.306 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.493879 | 0.306 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.494162 | 0.306 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.504557 | 0.297 |
| R-HSA-9033241 | Peroxisomal protein import | 0.509812 | 0.293 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.509812 | 0.293 |
| R-HSA-186712 | Regulation of beta-cell development | 0.509812 | 0.293 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.509812 | 0.293 |
| R-HSA-379724 | tRNA Aminoacylation | 0.515012 | 0.288 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.515012 | 0.288 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.520156 | 0.284 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.520156 | 0.284 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.520702 | 0.283 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.525247 | 0.280 |
| R-HSA-9707616 | Heme signaling | 0.525247 | 0.280 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.525247 | 0.280 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.530283 | 0.275 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.533622 | 0.273 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.536815 | 0.270 |
| R-HSA-74160 | Gene expression (Transcription) | 0.546954 | 0.262 |
| R-HSA-9609646 | HCMV Infection | 0.548116 | 0.261 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.549905 | 0.260 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.549905 | 0.260 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.554681 | 0.256 |
| R-HSA-5218859 | Regulated Necrosis | 0.554681 | 0.256 |
| R-HSA-5688426 | Deubiquitination | 0.560533 | 0.251 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.564084 | 0.249 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.564084 | 0.249 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.568711 | 0.245 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.568711 | 0.245 |
| R-HSA-109581 | Apoptosis | 0.570943 | 0.243 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.573289 | 0.242 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.577819 | 0.238 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.579972 | 0.237 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.582301 | 0.235 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.586736 | 0.232 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.587080 | 0.231 |
| R-HSA-5689603 | UCH proteinases | 0.591124 | 0.228 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.591845 | 0.228 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.597494 | 0.224 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.599761 | 0.222 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.599761 | 0.222 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.603225 | 0.220 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.604011 | 0.219 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.608217 | 0.216 |
| R-HSA-9833482 | PKR-mediated signaling | 0.608217 | 0.216 |
| R-HSA-212436 | Generic Transcription Pathway | 0.609555 | 0.215 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.612378 | 0.213 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.616495 | 0.210 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.619003 | 0.208 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.620569 | 0.207 |
| R-HSA-9658195 | Leishmania infection | 0.621696 | 0.206 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.621696 | 0.206 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.624600 | 0.204 |
| R-HSA-2559583 | Cellular Senescence | 0.625537 | 0.204 |
| R-HSA-1500620 | Meiosis | 0.628588 | 0.202 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.633652 | 0.198 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.640301 | 0.194 |
| R-HSA-9663891 | Selective autophagy | 0.644123 | 0.191 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.644123 | 0.191 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.651647 | 0.186 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.651647 | 0.186 |
| R-HSA-5617833 | Cilium Assembly | 0.652054 | 0.186 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.659013 | 0.181 |
| R-HSA-391251 | Protein folding | 0.662637 | 0.179 |
| R-HSA-9609690 | HCMV Early Events | 0.667240 | 0.176 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.676757 | 0.170 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.677066 | 0.169 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.680194 | 0.167 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.683594 | 0.165 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.683594 | 0.165 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.686959 | 0.163 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.694725 | 0.158 |
| R-HSA-1483255 | PI Metabolism | 0.700066 | 0.155 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.702136 | 0.154 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.706413 | 0.151 |
| R-HSA-9833110 | RSV-host interactions | 0.709537 | 0.149 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.712627 | 0.147 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.712627 | 0.147 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.718710 | 0.143 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.718710 | 0.143 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.724665 | 0.140 |
| R-HSA-8951664 | Neddylation | 0.726964 | 0.138 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.727596 | 0.138 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.727596 | 0.138 |
| R-HSA-9679506 | SARS-CoV Infections | 0.735207 | 0.134 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.741421 | 0.130 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.741789 | 0.130 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.744538 | 0.128 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.752612 | 0.123 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.753091 | 0.123 |
| R-HSA-68875 | Mitotic Prophase | 0.760432 | 0.119 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.762984 | 0.117 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.768007 | 0.115 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.770478 | 0.113 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.775343 | 0.111 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.775343 | 0.111 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.775343 | 0.111 |
| R-HSA-1474165 | Reproduction | 0.789331 | 0.103 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.792891 | 0.101 |
| R-HSA-9909396 | Circadian clock | 0.793798 | 0.100 |
| R-HSA-597592 | Post-translational protein modification | 0.795593 | 0.099 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.805061 | 0.094 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.808705 | 0.092 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.818692 | 0.087 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.818692 | 0.087 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.821032 | 0.086 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.829995 | 0.081 |
| R-HSA-69242 | S Phase | 0.829995 | 0.081 |
| R-HSA-9758941 | Gastrulation | 0.831809 | 0.080 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.832408 | 0.080 |
| R-HSA-9609507 | Protein localization | 0.838876 | 0.076 |
| R-HSA-69306 | DNA Replication | 0.838876 | 0.076 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.840597 | 0.075 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.840597 | 0.075 |
| R-HSA-1989781 | PPARA activates gene expression | 0.842298 | 0.075 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.845648 | 0.073 |
| R-HSA-9610379 | HCMV Late Events | 0.845648 | 0.073 |
| R-HSA-162587 | HIV Life Cycle | 0.845648 | 0.073 |
| R-HSA-9711097 | Cellular response to starvation | 0.847296 | 0.072 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.850541 | 0.070 |
| R-HSA-195721 | Signaling by WNT | 0.853234 | 0.069 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.856825 | 0.067 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.868616 | 0.061 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.871410 | 0.060 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.874145 | 0.058 |
| R-HSA-611105 | Respiratory electron transport | 0.878139 | 0.056 |
| R-HSA-3781865 | Diseases of glycosylation | 0.885753 | 0.053 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.894039 | 0.049 |
| R-HSA-428157 | Sphingolipid metabolism | 0.904851 | 0.043 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.906878 | 0.042 |
| R-HSA-6805567 | Keratinization | 0.910805 | 0.041 |
| R-HSA-392499 | Metabolism of proteins | 0.914815 | 0.039 |
| R-HSA-9824446 | Viral Infection Pathways | 0.926036 | 0.033 |
| R-HSA-162906 | HIV Infection | 0.928870 | 0.032 |
| R-HSA-913531 | Interferon Signaling | 0.929938 | 0.032 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.936144 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.938107 | 0.028 |
| R-HSA-1280218 | Adaptive Immune System | 0.940242 | 0.027 |
| R-HSA-72766 | Translation | 0.953532 | 0.021 |
| R-HSA-1483257 | Phospholipid metabolism | 0.965890 | 0.015 |
| R-HSA-168256 | Immune System | 0.972184 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 0.975092 | 0.011 |
| R-HSA-5663205 | Infectious disease | 0.978079 | 0.010 |
| R-HSA-168249 | Innate Immune System | 0.978166 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.979290 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.983362 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 0.991972 | 0.004 |
| R-HSA-6798695 | Neutrophil degranulation | 0.994217 | 0.003 |
| R-HSA-1643685 | Disease | 0.996720 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999016 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999826 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999891 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999931 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999991 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.851 | 0.204 | 2 | 0.839 |
CDC7 |
0.841 | 0.151 | 1 | 0.873 |
MOS |
0.839 | 0.232 | 1 | 0.857 |
CLK3 |
0.837 | 0.149 | 1 | 0.791 |
PIM3 |
0.834 | 0.084 | -3 | 0.807 |
BMPR1B |
0.832 | 0.259 | 1 | 0.848 |
GRK1 |
0.827 | 0.182 | -2 | 0.791 |
GRK6 |
0.827 | 0.239 | 1 | 0.810 |
NDR2 |
0.826 | 0.020 | -3 | 0.821 |
PRPK |
0.826 | -0.072 | -1 | 0.826 |
RAF1 |
0.825 | -0.047 | 1 | 0.762 |
CK2A2 |
0.825 | 0.458 | 1 | 0.835 |
DSTYK |
0.824 | -0.008 | 2 | 0.832 |
CAMK2G |
0.824 | 0.044 | 2 | 0.766 |
IKKB |
0.824 | -0.030 | -2 | 0.736 |
CAMK1B |
0.823 | 0.023 | -3 | 0.812 |
NLK |
0.823 | 0.024 | 1 | 0.772 |
SKMLCK |
0.823 | 0.079 | -2 | 0.857 |
KIS |
0.823 | 0.083 | 1 | 0.664 |
NUAK2 |
0.822 | 0.049 | -3 | 0.802 |
RSK2 |
0.821 | 0.060 | -3 | 0.718 |
PIM1 |
0.821 | 0.071 | -3 | 0.747 |
TBK1 |
0.820 | -0.078 | 1 | 0.645 |
IKKA |
0.820 | 0.060 | -2 | 0.727 |
AMPKA1 |
0.820 | 0.082 | -3 | 0.819 |
TGFBR1 |
0.819 | 0.160 | -2 | 0.801 |
PLK1 |
0.819 | 0.168 | -2 | 0.853 |
PKN3 |
0.819 | -0.008 | -3 | 0.786 |
MTOR |
0.819 | -0.101 | 1 | 0.708 |
ERK5 |
0.819 | 0.017 | 1 | 0.744 |
GRK7 |
0.819 | 0.244 | 1 | 0.723 |
FAM20C |
0.819 | 0.089 | 2 | 0.551 |
BMPR2 |
0.818 | -0.113 | -2 | 0.874 |
MARK4 |
0.818 | 0.063 | 4 | 0.859 |
RIPK3 |
0.818 | -0.047 | 3 | 0.630 |
HUNK |
0.818 | -0.003 | 2 | 0.767 |
CAMK2B |
0.817 | 0.108 | 2 | 0.740 |
GCN2 |
0.816 | -0.175 | 2 | 0.758 |
IKKE |
0.816 | -0.097 | 1 | 0.642 |
ATR |
0.816 | -0.027 | 1 | 0.752 |
MAPKAPK2 |
0.816 | 0.070 | -3 | 0.700 |
CDKL1 |
0.816 | -0.021 | -3 | 0.745 |
GRK5 |
0.816 | 0.009 | -3 | 0.833 |
CK2A1 |
0.816 | 0.430 | 1 | 0.823 |
NDR1 |
0.815 | -0.024 | -3 | 0.803 |
PDHK4 |
0.815 | -0.250 | 1 | 0.769 |
BMPR1A |
0.815 | 0.206 | 1 | 0.834 |
PRKD1 |
0.815 | -0.010 | -3 | 0.782 |
TSSK2 |
0.814 | 0.069 | -5 | 0.803 |
DAPK2 |
0.814 | 0.027 | -3 | 0.815 |
CAMLCK |
0.814 | 0.005 | -2 | 0.850 |
TGFBR2 |
0.814 | -0.053 | -2 | 0.818 |
ULK2 |
0.814 | -0.166 | 2 | 0.739 |
PRKD2 |
0.814 | 0.013 | -3 | 0.729 |
NIK |
0.814 | -0.050 | -3 | 0.843 |
ACVR2B |
0.813 | 0.160 | -2 | 0.810 |
PKN2 |
0.813 | -0.010 | -3 | 0.800 |
LATS2 |
0.813 | 0.009 | -5 | 0.683 |
SRPK1 |
0.813 | 0.013 | -3 | 0.698 |
P90RSK |
0.813 | -0.001 | -3 | 0.721 |
AMPKA2 |
0.812 | 0.053 | -3 | 0.786 |
NEK6 |
0.812 | -0.091 | -2 | 0.861 |
ALK4 |
0.812 | 0.092 | -2 | 0.819 |
LATS1 |
0.812 | 0.096 | -3 | 0.826 |
TSSK1 |
0.812 | 0.062 | -3 | 0.832 |
MST4 |
0.812 | -0.038 | 2 | 0.792 |
ACVR2A |
0.811 | 0.141 | -2 | 0.796 |
CAMK2A |
0.811 | 0.085 | 2 | 0.761 |
PKCD |
0.811 | -0.003 | 2 | 0.739 |
MLK1 |
0.811 | -0.097 | 2 | 0.764 |
NEK7 |
0.811 | -0.159 | -3 | 0.803 |
PLK3 |
0.811 | 0.147 | 2 | 0.734 |
P70S6KB |
0.810 | 0.006 | -3 | 0.745 |
MAPKAPK3 |
0.810 | -0.003 | -3 | 0.740 |
WNK1 |
0.810 | -0.061 | -2 | 0.851 |
ALK2 |
0.810 | 0.135 | -2 | 0.816 |
PKACG |
0.808 | 0.010 | -2 | 0.751 |
RSK4 |
0.808 | 0.066 | -3 | 0.700 |
PDHK1 |
0.808 | -0.241 | 1 | 0.743 |
CDKL5 |
0.808 | -0.029 | -3 | 0.731 |
DLK |
0.807 | -0.062 | 1 | 0.762 |
ATM |
0.807 | 0.012 | 1 | 0.702 |
GRK4 |
0.807 | -0.025 | -2 | 0.831 |
AURC |
0.807 | 0.050 | -2 | 0.674 |
RSK3 |
0.807 | -0.023 | -3 | 0.724 |
ICK |
0.807 | -0.017 | -3 | 0.784 |
NUAK1 |
0.807 | 0.006 | -3 | 0.754 |
CAMK2D |
0.806 | -0.054 | -3 | 0.787 |
ULK1 |
0.806 | -0.158 | -3 | 0.777 |
JNK2 |
0.806 | 0.109 | 1 | 0.616 |
CLK2 |
0.806 | 0.110 | -3 | 0.711 |
MARK3 |
0.806 | 0.104 | 4 | 0.833 |
CHAK2 |
0.806 | -0.081 | -1 | 0.840 |
ANKRD3 |
0.806 | -0.104 | 1 | 0.756 |
QSK |
0.805 | 0.038 | 4 | 0.846 |
JNK3 |
0.805 | 0.099 | 1 | 0.641 |
MARK2 |
0.804 | 0.091 | 4 | 0.794 |
SRPK2 |
0.804 | -0.000 | -3 | 0.619 |
CDK1 |
0.803 | 0.058 | 1 | 0.640 |
HIPK4 |
0.803 | -0.038 | 1 | 0.708 |
MSK1 |
0.803 | 0.039 | -3 | 0.706 |
PKACB |
0.803 | 0.056 | -2 | 0.696 |
PAK1 |
0.803 | 0.004 | -2 | 0.787 |
MASTL |
0.803 | -0.229 | -2 | 0.804 |
PRKX |
0.803 | 0.083 | -3 | 0.659 |
BRSK1 |
0.803 | 0.019 | -3 | 0.758 |
CDK8 |
0.803 | 0.009 | 1 | 0.649 |
DYRK2 |
0.802 | 0.038 | 1 | 0.660 |
CAMK4 |
0.802 | -0.061 | -3 | 0.784 |
MSK2 |
0.802 | -0.021 | -3 | 0.697 |
MYLK4 |
0.802 | 0.029 | -2 | 0.788 |
WNK3 |
0.802 | -0.201 | 1 | 0.695 |
NIM1 |
0.801 | -0.084 | 3 | 0.674 |
GRK2 |
0.801 | 0.060 | -2 | 0.703 |
DRAK1 |
0.801 | 0.065 | 1 | 0.779 |
BCKDK |
0.801 | -0.173 | -1 | 0.767 |
CLK4 |
0.800 | 0.033 | -3 | 0.718 |
PKCB |
0.800 | -0.024 | 2 | 0.691 |
NEK9 |
0.800 | -0.209 | 2 | 0.782 |
MELK |
0.799 | -0.042 | -3 | 0.760 |
MNK2 |
0.799 | -0.009 | -2 | 0.797 |
PKR |
0.798 | -0.065 | 1 | 0.730 |
RIPK1 |
0.798 | -0.205 | 1 | 0.699 |
MLK2 |
0.798 | -0.178 | 2 | 0.768 |
MLK3 |
0.798 | -0.075 | 2 | 0.688 |
P38G |
0.798 | 0.075 | 1 | 0.553 |
SIK |
0.798 | -0.012 | -3 | 0.721 |
AURA |
0.798 | 0.042 | -2 | 0.656 |
MARK1 |
0.798 | 0.052 | 4 | 0.835 |
CDK18 |
0.798 | 0.044 | 1 | 0.593 |
MLK4 |
0.798 | -0.056 | 2 | 0.676 |
TTBK2 |
0.798 | -0.135 | 2 | 0.639 |
CDK7 |
0.798 | 0.000 | 1 | 0.660 |
MEK1 |
0.797 | -0.092 | 2 | 0.793 |
QIK |
0.797 | -0.066 | -3 | 0.786 |
SRPK3 |
0.797 | -0.026 | -3 | 0.671 |
CDK5 |
0.797 | 0.028 | 1 | 0.669 |
CLK1 |
0.797 | 0.026 | -3 | 0.698 |
CHK1 |
0.797 | -0.005 | -3 | 0.818 |
AURB |
0.796 | 0.021 | -2 | 0.674 |
P38B |
0.796 | 0.067 | 1 | 0.619 |
PAK3 |
0.796 | -0.058 | -2 | 0.786 |
CDK19 |
0.796 | 0.005 | 1 | 0.617 |
P38A |
0.796 | 0.044 | 1 | 0.666 |
IRE1 |
0.795 | -0.138 | 1 | 0.664 |
IRE2 |
0.795 | -0.095 | 2 | 0.715 |
PRKD3 |
0.795 | -0.050 | -3 | 0.700 |
PKCG |
0.794 | -0.058 | 2 | 0.684 |
MNK1 |
0.794 | -0.009 | -2 | 0.808 |
ERK1 |
0.794 | 0.043 | 1 | 0.604 |
SGK3 |
0.794 | 0.009 | -3 | 0.730 |
CDK17 |
0.794 | 0.041 | 1 | 0.558 |
YSK4 |
0.794 | -0.131 | 1 | 0.684 |
SSTK |
0.794 | 0.066 | 4 | 0.816 |
BRSK2 |
0.793 | -0.049 | -3 | 0.774 |
PKCA |
0.793 | -0.056 | 2 | 0.679 |
PASK |
0.793 | 0.064 | -3 | 0.823 |
PKG2 |
0.793 | 0.002 | -2 | 0.684 |
ERK2 |
0.793 | 0.030 | 1 | 0.636 |
GSK3A |
0.792 | 0.093 | 4 | 0.474 |
HIPK1 |
0.792 | 0.033 | 1 | 0.669 |
HIPK2 |
0.792 | 0.042 | 1 | 0.584 |
DNAPK |
0.792 | -0.013 | 1 | 0.618 |
DYRK4 |
0.792 | 0.069 | 1 | 0.611 |
CDK16 |
0.792 | 0.073 | 1 | 0.567 |
PAK2 |
0.792 | -0.044 | -2 | 0.774 |
PLK4 |
0.792 | -0.061 | 2 | 0.600 |
BRAF |
0.792 | -0.049 | -4 | 0.806 |
PIM2 |
0.791 | -0.002 | -3 | 0.694 |
PLK2 |
0.791 | 0.158 | -3 | 0.880 |
VRK2 |
0.791 | -0.247 | 1 | 0.775 |
PKCH |
0.791 | -0.067 | 2 | 0.675 |
CDK2 |
0.791 | -0.020 | 1 | 0.702 |
CDK13 |
0.791 | -0.011 | 1 | 0.630 |
GRK3 |
0.791 | 0.065 | -2 | 0.662 |
CAMK1G |
0.790 | -0.030 | -3 | 0.699 |
PAK6 |
0.790 | 0.004 | -2 | 0.709 |
AKT2 |
0.790 | -0.008 | -3 | 0.637 |
PKCZ |
0.789 | -0.087 | 2 | 0.729 |
MEKK3 |
0.789 | -0.078 | 1 | 0.719 |
TLK2 |
0.789 | -0.084 | 1 | 0.685 |
CDK3 |
0.789 | 0.039 | 1 | 0.577 |
P38D |
0.788 | 0.074 | 1 | 0.562 |
NEK2 |
0.788 | -0.152 | 2 | 0.758 |
CK1E |
0.788 | -0.000 | -3 | 0.556 |
DCAMKL1 |
0.787 | -0.031 | -3 | 0.760 |
DAPK3 |
0.787 | 0.055 | -3 | 0.759 |
DYRK1A |
0.787 | 0.003 | 1 | 0.688 |
PHKG1 |
0.787 | -0.141 | -3 | 0.788 |
GSK3B |
0.787 | 0.036 | 4 | 0.465 |
CDK14 |
0.787 | 0.033 | 1 | 0.629 |
DYRK1B |
0.786 | 0.040 | 1 | 0.634 |
PRP4 |
0.786 | -0.012 | -3 | 0.740 |
SMG1 |
0.786 | -0.101 | 1 | 0.693 |
GAK |
0.786 | 0.070 | 1 | 0.757 |
SMMLCK |
0.786 | -0.023 | -3 | 0.762 |
PKACA |
0.784 | 0.023 | -2 | 0.638 |
CAMK1D |
0.784 | 0.004 | -3 | 0.653 |
ZAK |
0.784 | -0.140 | 1 | 0.692 |
JNK1 |
0.784 | 0.070 | 1 | 0.613 |
MST3 |
0.784 | -0.051 | 2 | 0.782 |
CHAK1 |
0.784 | -0.198 | 2 | 0.711 |
SNRK |
0.783 | -0.179 | 2 | 0.656 |
MEKK1 |
0.783 | -0.187 | 1 | 0.706 |
CDK12 |
0.783 | -0.011 | 1 | 0.607 |
CDK9 |
0.783 | -0.027 | 1 | 0.633 |
CDK10 |
0.783 | 0.041 | 1 | 0.620 |
DAPK1 |
0.782 | 0.061 | -3 | 0.737 |
MEKK2 |
0.782 | -0.134 | 2 | 0.753 |
TLK1 |
0.781 | -0.101 | -2 | 0.837 |
NEK5 |
0.781 | -0.164 | 1 | 0.707 |
MEK5 |
0.781 | -0.257 | 2 | 0.777 |
PERK |
0.780 | -0.192 | -2 | 0.843 |
TAO3 |
0.780 | -0.091 | 1 | 0.707 |
DYRK3 |
0.780 | 0.014 | 1 | 0.665 |
CK1D |
0.779 | -0.005 | -3 | 0.503 |
AKT1 |
0.779 | -0.011 | -3 | 0.661 |
IRAK4 |
0.779 | -0.155 | 1 | 0.663 |
HIPK3 |
0.778 | -0.030 | 1 | 0.650 |
HRI |
0.778 | -0.238 | -2 | 0.847 |
DCAMKL2 |
0.778 | -0.075 | -3 | 0.772 |
P70S6K |
0.778 | -0.056 | -3 | 0.649 |
WNK4 |
0.776 | -0.177 | -2 | 0.830 |
MAPKAPK5 |
0.776 | -0.171 | -3 | 0.656 |
PKCT |
0.776 | -0.093 | 2 | 0.683 |
PINK1 |
0.775 | -0.219 | 1 | 0.725 |
CK1A2 |
0.775 | -0.016 | -3 | 0.500 |
LKB1 |
0.774 | -0.105 | -3 | 0.800 |
MST2 |
0.774 | -0.068 | 1 | 0.729 |
NEK11 |
0.774 | -0.172 | 1 | 0.711 |
CAMKK1 |
0.774 | -0.155 | -2 | 0.765 |
GCK |
0.773 | -0.062 | 1 | 0.728 |
CAMKK2 |
0.772 | -0.117 | -2 | 0.752 |
MPSK1 |
0.772 | -0.089 | 1 | 0.663 |
NEK8 |
0.771 | -0.192 | 2 | 0.769 |
PHKG2 |
0.771 | -0.121 | -3 | 0.753 |
ERK7 |
0.770 | -0.014 | 2 | 0.512 |
TAO2 |
0.770 | -0.156 | 2 | 0.794 |
IRAK1 |
0.770 | -0.248 | -1 | 0.711 |
CK1G1 |
0.770 | -0.083 | -3 | 0.554 |
PAK5 |
0.769 | -0.040 | -2 | 0.648 |
PKCE |
0.769 | -0.046 | 2 | 0.668 |
ROCK2 |
0.769 | 0.018 | -3 | 0.757 |
PKCI |
0.769 | -0.097 | 2 | 0.693 |
MRCKA |
0.769 | 0.010 | -3 | 0.714 |
EEF2K |
0.769 | -0.081 | 3 | 0.690 |
SGK1 |
0.769 | -0.000 | -3 | 0.565 |
MAK |
0.769 | 0.035 | -2 | 0.731 |
CAMK1A |
0.768 | -0.021 | -3 | 0.617 |
TTBK1 |
0.768 | -0.177 | 2 | 0.564 |
AKT3 |
0.767 | -0.014 | -3 | 0.580 |
CDK6 |
0.766 | -0.000 | 1 | 0.603 |
MRCKB |
0.766 | -0.008 | -3 | 0.694 |
TAK1 |
0.766 | -0.128 | 1 | 0.725 |
PAK4 |
0.765 | -0.039 | -2 | 0.660 |
CDK4 |
0.765 | 0.002 | 1 | 0.593 |
MINK |
0.765 | -0.136 | 1 | 0.689 |
NEK4 |
0.765 | -0.201 | 1 | 0.671 |
HPK1 |
0.765 | -0.095 | 1 | 0.711 |
TNIK |
0.765 | -0.107 | 3 | 0.691 |
PDK1 |
0.765 | -0.173 | 1 | 0.692 |
TTK |
0.764 | 0.012 | -2 | 0.862 |
CHK2 |
0.764 | -0.065 | -3 | 0.587 |
MAP3K15 |
0.764 | -0.168 | 1 | 0.664 |
MEKK6 |
0.763 | -0.182 | 1 | 0.685 |
DMPK1 |
0.763 | 0.038 | -3 | 0.716 |
VRK1 |
0.762 | -0.183 | 2 | 0.792 |
SBK |
0.762 | -0.015 | -3 | 0.516 |
MST1 |
0.762 | -0.115 | 1 | 0.696 |
PKN1 |
0.762 | -0.088 | -3 | 0.665 |
HGK |
0.761 | -0.163 | 3 | 0.694 |
PDHK3_TYR |
0.761 | 0.237 | 4 | 0.837 |
LRRK2 |
0.760 | -0.212 | 2 | 0.794 |
NEK1 |
0.760 | -0.189 | 1 | 0.672 |
KHS2 |
0.760 | -0.063 | 1 | 0.700 |
MOK |
0.760 | -0.010 | 1 | 0.663 |
KHS1 |
0.758 | -0.107 | 1 | 0.678 |
LOK |
0.758 | -0.148 | -2 | 0.756 |
PDHK4_TYR |
0.756 | 0.191 | 2 | 0.844 |
ALPHAK3 |
0.755 | 0.007 | -1 | 0.774 |
PBK |
0.755 | -0.077 | 1 | 0.671 |
SLK |
0.754 | -0.138 | -2 | 0.693 |
STK33 |
0.754 | -0.190 | 2 | 0.566 |
MEK2 |
0.754 | -0.257 | 2 | 0.761 |
BUB1 |
0.753 | -0.051 | -5 | 0.722 |
ROCK1 |
0.753 | -0.010 | -3 | 0.713 |
RIPK2 |
0.753 | -0.280 | 1 | 0.653 |
OSR1 |
0.752 | -0.093 | 2 | 0.750 |
BMPR2_TYR |
0.752 | 0.129 | -1 | 0.863 |
TXK |
0.752 | 0.194 | 1 | 0.859 |
MAP2K6_TYR |
0.752 | 0.113 | -1 | 0.851 |
YSK1 |
0.751 | -0.180 | 2 | 0.751 |
CRIK |
0.751 | -0.010 | -3 | 0.658 |
PDHK1_TYR |
0.750 | 0.096 | -1 | 0.869 |
BIKE |
0.749 | -0.019 | 1 | 0.635 |
TESK1_TYR |
0.749 | -0.045 | 3 | 0.753 |
PKG1 |
0.748 | -0.062 | -2 | 0.593 |
EPHA6 |
0.747 | 0.077 | -1 | 0.870 |
MAP2K4_TYR |
0.746 | -0.047 | -1 | 0.839 |
HASPIN |
0.745 | -0.079 | -1 | 0.646 |
MAP2K7_TYR |
0.744 | -0.105 | 2 | 0.810 |
CK1A |
0.744 | -0.029 | -3 | 0.420 |
EPHB4 |
0.743 | 0.020 | -1 | 0.828 |
PKMYT1_TYR |
0.742 | -0.146 | 3 | 0.725 |
ASK1 |
0.741 | -0.185 | 1 | 0.657 |
YANK3 |
0.739 | -0.099 | 2 | 0.367 |
NEK3 |
0.739 | -0.285 | 1 | 0.634 |
YES1 |
0.739 | 0.011 | -1 | 0.805 |
PINK1_TYR |
0.739 | -0.176 | 1 | 0.751 |
MYO3A |
0.738 | -0.161 | 1 | 0.672 |
INSRR |
0.738 | -0.007 | 3 | 0.641 |
MYO3B |
0.737 | -0.172 | 2 | 0.768 |
RET |
0.737 | -0.117 | 1 | 0.684 |
BLK |
0.737 | 0.076 | -1 | 0.822 |
LIMK2_TYR |
0.737 | -0.106 | -3 | 0.849 |
SRMS |
0.737 | 0.038 | 1 | 0.820 |
FER |
0.736 | -0.035 | 1 | 0.820 |
EPHA4 |
0.735 | 0.016 | 2 | 0.735 |
LCK |
0.735 | 0.035 | -1 | 0.815 |
EPHB1 |
0.735 | -0.002 | 1 | 0.808 |
ITK |
0.735 | 0.012 | -1 | 0.767 |
TYRO3 |
0.734 | -0.127 | 3 | 0.662 |
EPHB2 |
0.734 | 0.022 | -1 | 0.812 |
STLK3 |
0.733 | -0.167 | 1 | 0.656 |
FGR |
0.733 | -0.072 | 1 | 0.772 |
ABL2 |
0.732 | -0.067 | -1 | 0.792 |
DDR1 |
0.732 | -0.117 | 4 | 0.750 |
AAK1 |
0.732 | 0.008 | 1 | 0.535 |
ROS1 |
0.731 | -0.164 | 3 | 0.634 |
TAO1 |
0.731 | -0.208 | 1 | 0.619 |
CSF1R |
0.731 | -0.118 | 3 | 0.660 |
FYN |
0.731 | 0.083 | -1 | 0.797 |
EPHB3 |
0.731 | -0.034 | -1 | 0.816 |
JAK3 |
0.731 | -0.095 | 1 | 0.683 |
HCK |
0.730 | -0.050 | -1 | 0.804 |
BMX |
0.730 | 0.004 | -1 | 0.701 |
LIMK1_TYR |
0.730 | -0.240 | 2 | 0.796 |
MST1R |
0.729 | -0.210 | 3 | 0.677 |
TEC |
0.728 | -0.021 | -1 | 0.704 |
FGFR2 |
0.727 | -0.109 | 3 | 0.692 |
KDR |
0.727 | -0.087 | 3 | 0.639 |
TYK2 |
0.727 | -0.270 | 1 | 0.676 |
PTK2 |
0.727 | 0.127 | -1 | 0.823 |
TNK2 |
0.726 | -0.112 | 3 | 0.645 |
KIT |
0.726 | -0.108 | 3 | 0.673 |
MERTK |
0.725 | -0.064 | 3 | 0.661 |
ABL1 |
0.725 | -0.106 | -1 | 0.782 |
EPHA7 |
0.725 | -0.026 | 2 | 0.736 |
JAK2 |
0.724 | -0.252 | 1 | 0.676 |
MET |
0.724 | -0.077 | 3 | 0.659 |
PTK2B |
0.723 | 0.016 | -1 | 0.747 |
TEK |
0.723 | -0.135 | 3 | 0.622 |
FGFR1 |
0.722 | -0.138 | 3 | 0.667 |
PDGFRB |
0.722 | -0.185 | 3 | 0.675 |
DDR2 |
0.722 | -0.020 | 3 | 0.635 |
AXL |
0.722 | -0.130 | 3 | 0.669 |
FLT1 |
0.722 | -0.050 | -1 | 0.838 |
EPHA5 |
0.721 | -0.002 | 2 | 0.724 |
CK1G3 |
0.720 | -0.056 | -3 | 0.377 |
FGFR3 |
0.720 | -0.086 | 3 | 0.671 |
SYK |
0.720 | 0.096 | -1 | 0.802 |
FLT3 |
0.719 | -0.178 | 3 | 0.657 |
EPHA3 |
0.719 | -0.088 | 2 | 0.708 |
TNNI3K_TYR |
0.718 | -0.117 | 1 | 0.704 |
LYN |
0.718 | -0.047 | 3 | 0.611 |
ALK |
0.718 | -0.135 | 3 | 0.608 |
EPHA8 |
0.718 | -0.019 | -1 | 0.814 |
FRK |
0.716 | -0.080 | -1 | 0.817 |
SRC |
0.716 | -0.020 | -1 | 0.785 |
LTK |
0.716 | -0.139 | 3 | 0.628 |
NTRK1 |
0.715 | -0.170 | -1 | 0.794 |
NEK10_TYR |
0.715 | -0.177 | 1 | 0.561 |
ERBB2 |
0.715 | -0.134 | 1 | 0.674 |
TNK1 |
0.715 | -0.196 | 3 | 0.646 |
BTK |
0.715 | -0.186 | -1 | 0.716 |
INSR |
0.715 | -0.133 | 3 | 0.614 |
JAK1 |
0.714 | -0.183 | 1 | 0.631 |
EGFR |
0.713 | -0.041 | 1 | 0.596 |
EPHA1 |
0.713 | -0.137 | 3 | 0.642 |
FLT4 |
0.712 | -0.159 | 3 | 0.642 |
PTK6 |
0.711 | -0.178 | -1 | 0.693 |
MATK |
0.711 | -0.102 | -1 | 0.732 |
NTRK2 |
0.711 | -0.200 | 3 | 0.647 |
NTRK3 |
0.709 | -0.143 | -1 | 0.752 |
PDGFRA |
0.709 | -0.289 | 3 | 0.663 |
WEE1_TYR |
0.708 | -0.171 | -1 | 0.710 |
EPHA2 |
0.708 | -0.027 | -1 | 0.783 |
FGFR4 |
0.707 | -0.087 | -1 | 0.762 |
ERBB4 |
0.707 | -0.021 | 1 | 0.657 |
YANK2 |
0.705 | -0.124 | 2 | 0.379 |
CSK |
0.704 | -0.131 | 2 | 0.738 |
IGF1R |
0.703 | -0.107 | 3 | 0.574 |
CK1G2 |
0.702 | -0.063 | -3 | 0.473 |
FES |
0.694 | -0.079 | -1 | 0.681 |
ZAP70 |
0.690 | -0.037 | -1 | 0.724 |
MUSK |
0.689 | -0.195 | 1 | 0.572 |