Motif 649 (n=241)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2193 | ochoa | Snf2 related CREBBP activator protein | None |
| A0AVK6 | E2F8 | S357 | ochoa | Transcription factor E2F8 (E2F-8) | Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}. |
| A6H8Y1 | BDP1 | S292 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6H8Y1 | BDP1 | S1783 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NKT7 | RGPD3 | S1264 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BU86 | STX16-NPEPL1 | S34 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| H8Y6P7 | GCOM1 | S575 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
| O00418 | EEF2K | S477 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14514 | ADGRB1 | S1468 | ochoa | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}. |
| O14530 | TXNDC9 | S181 | ochoa | Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) | Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. {ECO:0000269|PubMed:16415341}. |
| O14639 | ABLIM1 | S352 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14662 | STX16 | S34 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14686 | KMT2D | S2654 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S1263 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15013 | ARHGEF10 | S200 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15400 | STX7 | S125 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15439 | ABCC4 | S664 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43148 | RNMT | S71 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43166 | SIPA1L1 | S96 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43683 | BUB1 | S436 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43707 | ACTN4 | S262 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60237 | PPP1R12B | S789 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60242 | ADGRB3 | S1410 | ochoa | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}. |
| O75112 | LDB3 | S267 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75122 | CLASP2 | S21 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75143 | ATG13 | S355 | ochoa|psp | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75153 | CLUH | S669 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75533 | SF3B1 | S72 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94864 | SUPT7L | S327 | ochoa | STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) | None |
| O94875 | SORBS2 | S234 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94967 | WDR47 | S565 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O94992 | HEXIM1 | S97 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95071 | UBR5 | S1701 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95210 | STBD1 | S210 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95239 | KIF4A | S507 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95400 | CD2BP2 | S60 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| P00533 | EGFR | S1070 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02748 | C9 | S260 | ochoa | Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] | Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:34752492, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:6177822, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. |
| P04049 | RAF1 | S227 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P05023 | ATP1A1 | S216 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P06241 | FYN | S25 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07900 | HSP90AA1 | S52 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08183 | ABCB1 | S660 | ochoa | ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) | Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}. |
| P0CAP2 | POLR2M | S178 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
| P12814 | ACTN1 | S243 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12814 | ACTN1 | S471 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13010 | XRCC5 | S579 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13637 | ATP1A3 | S206 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P17028 | ZNF24 | S38 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P20309 | CHRM3 | S286 | ochoa | Muscarinic acetylcholine receptor M3 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| P20648 | ATP4A | S227 | ochoa | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P21333 | FLNA | S630 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21359 | NF1 | S2586 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P22681 | CBL | S704 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23588 | EIF4B | S424 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S588 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P29401 | TKT | S104 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29590 | PML | S582 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P35611 | ADD1 | Y419 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35670 | ATP7B | S340 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P40425 | PBX2 | S104 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P42330 | AKR1C3 | S67 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P42566 | EPS15 | S606 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P43121 | MCAM | S627 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P48382 | RFX5 | S312 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49792 | RANBP2 | S2239 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49795 | RGS19 | S24 | psp | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| P49916 | LIG3 | S853 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50993 | ATP1A2 | S214 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P52566 | ARHGDIB | S20 | ochoa|psp | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P54105 | CLNS1A | S197 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P54132 | BLM | S1295 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54296 | MYOM2 | S555 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54646 | PRKAA2 | S483 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P55196 | AFDN | S239 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57737 | CORO7 | S879 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P61129 | ZC3H6 | S187 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
| P98182 | ZNF200 | S181 | ochoa | Zinc finger protein 200 | Localizes protein arginine N-methyltransferase PRMT3 to the nucleus. {ECO:0000269|PubMed:39513743}. |
| Q00653 | NFKB2 | S22 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00653 | NFKB2 | S726 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q02388 | COL7A1 | S1966 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q04828 | AKR1C1 | S67 | ochoa | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}. |
| Q06455 | RUNX1T1 | S408 | ochoa | Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| Q12872 | SFSWAP | S617 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12959 | DLG1 | S570 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13315 | ATM | S1987 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13322 | GRB10 | S133 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13370 | PDE3B | S279 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13416 | ORC2 | S249 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13426 | XRCC4 | S303 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13615 | MTMR3 | S651 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q14161 | GIT2 | S499 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14191 | WRN | S1399 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14202 | ZMYM3 | S949 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14202 | ZMYM3 | S1054 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14315 | FLNC | S625 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14568 | HSP90AA2P | S52 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q14653 | IRF3 | S385 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14674 | ESPL1 | S1538 | ochoa | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14847 | LASP1 | S150 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q15334 | LLGL1 | S1040 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15424 | SAFB | S372 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15464 | SHB | S101 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15776 | ZKSCAN8 | S37 | ochoa | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) | May be involved in transcriptional regulation. |
| Q15911 | ZFHX3 | S518 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q17RC7 | EXOC3L4 | S79 | ochoa | Exocyst complex component 3-like protein 4 | None |
| Q2NKX8 | ERCC6L | S1041 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3MIW9 | MUCL3 | S125 | ochoa | Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) | May modulate NF-kappaB signaling and play a role in cell growth. {ECO:0000269|PubMed:29242154}. |
| Q3V6T2 | CCDC88A | S1717 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5FWE3 | PRRT3 | S768 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JSZ5 | PRRC2B | S998 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTV8 | TOR1AIP1 | S230 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5JTV8 | TOR1AIP1 | S252 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5QJE6 | DNTTIP2 | S189 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S269 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SYE7 | NHSL1 | S165 | ochoa | NHS-like protein 1 | None |
| Q5TCZ1 | SH3PXD2A | S638 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TH69 | ARFGEF3 | S1851 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5UIP0 | RIF1 | S978 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S711 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S816 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q63HQ0 | AP1AR | S174 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q6KC79 | NIPBL | S1089 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NZI2 | CAVIN1 | S365 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6WKZ4 | RAB11FIP1 | S267 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZRS2 | SRCAP | S2370 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRV2 | FAM83H | S1024 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZUJ8 | PIK3AP1 | S572 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7L3B6 | CDC37L1 | S31 | ochoa | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | S1264 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z401 | DENND4A | S1281 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z589 | EMSY | S1101 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86TV6 | TTC7B | S677 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86V48 | LUZP1 | S995 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W50 | METTL16 | S483 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IVT5 | KSR1 | S184 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8N3S3 | PHTF2 | S221 | ochoa | Protein PHTF2 | None |
| Q8N3X1 | FNBP4 | S431 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8N4N8 | KIF2B | S200 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N697 | SLC15A4 | S290 | ochoa | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}. |
| Q8N6H7 | ARFGAP2 | S418 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N6Q8 | METTL25 | S350 | ochoa | Probable methyltransferase-like protein 25 (EC 2.1.1.-) | Probable methyltransferase. {ECO:0000305}. |
| Q8N6T3 | ARFGAP1 | S128 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8N9T8 | KRI1 | S182 | ochoa | Protein KRI1 homolog | None |
| Q8NCE2 | MTMR14 | S517 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NCN4 | RNF169 | S531 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NE01 | CNNM3 | S688 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NFA0 | USP32 | S1349 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
| Q8NG31 | KNL1 | S793 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TBA6 | GOLGA5 | S129 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TBA6 | GOLGA5 | S203 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TF40 | FNIP1 | S938 | psp | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8TF72 | SHROOM3 | S1137 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUA4 | GTF3C2 | S775 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUM0 | NUP133 | S492 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WZ73 | RFFL | S229 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92530 | PSMF1 | S152 | ochoa | Proteasome inhibitor PI31 subunit (hPI31) | Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}. |
| Q92539 | LPIN2 | S186 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92576 | PHF3 | S345 | ochoa | PHD finger protein 3 | None |
| Q92613 | JADE3 | S793 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92614 | MYO18A | S2031 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92785 | DPF2 | S117 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92835 | INPP5D | S1026 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92974 | ARHGEF2 | S721 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q92985 | IRF7 | S471 | psp | Interferon regulatory factor 7 (IRF-7) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}. |
| Q96AJ9 | VTI1A | S110 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Q96BT3 | CENPT | S183 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96BY7 | ATG2B | S1159 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96EB6 | SIRT1 | S172 | psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96FZ2 | HMCES | S315 | ochoa | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235913, PubMed:31235915, PubMed:32307824, PubMed:32492421). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). The HMCES DNA-protein cross-link is then either reversed or degraded (PubMed:30554877, PubMed:36608669, PubMed:37519246, PubMed:37950866). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (PubMed:37519246, PubMed:37950866). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351, ECO:0000269|PubMed:32307824, ECO:0000269|PubMed:32492421, ECO:0000269|PubMed:35450882, ECO:0000269|PubMed:36608669, ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866}. |
| Q96GY0 | ZC2HC1A | S278 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96IQ7 | VSIG2 | S302 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96JM2 | ZNF462 | S2144 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96K76 | USP47 | S148 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96P48 | ARAP1 | S428 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q96QB1 | DLC1 | S598 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96RL1 | UIMC1 | S401 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96TC7 | RMDN3 | S224 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99569 | PKP4 | S82 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99661 | KIF2C | S179 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99666 | RGPD5 | S1263 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQE4 | SELENOS | S146 | ochoa | Selenoprotein S (SelS) (VCP-interacting membrane protein) | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}. |
| Q9BUH8 | BEGAIN | S196 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BVS4 | RIOK2 | S369 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BVS4 | RIOK2 | S456 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BXL5 | HEMGN | S187 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BZL6 | PRKD2 | S374 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C0C2 | TNKS1BP1 | S1620 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1677 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C9 | UBE2O | S98 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0H5 | ARHGAP39 | S122 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H0B6 | KLC2 | S539 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H201 | EPN3 | S505 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H4A3 | WNK1 | S2011 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H5J8 | TAF1D | S26 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6U6 | BCAS3 | S849 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H9A7 | RMI1 | S274 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HCD5 | NCOA5 | S377 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCH5 | SYTL2 | S480 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NPI1 | BRD7 | S41 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NQG5 | RPRD1B | Y165 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NUY8 | TBC1D23 | S567 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NVW2 | RLIM | S163 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NYF8 | BCLAF1 | S205 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZ63 | C9orf78 | S156 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9NZT2 | OGFR | S54 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P0K7 | RAI14 | S317 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P273 | TENM3 | S26 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P275 | USP36 | S439 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2D6 | FAM135A | S639 | ochoa | Protein FAM135A | None |
| Q9P2Y5 | UVRAG | S549 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UBU9 | NXF1 | S62 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UDY2 | TJP2 | S947 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGU5 | HMGXB4 | S54 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UHW9 | SLC12A6 | S147 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UJC3 | HOOK1 | S166 | ochoa | Protein Hook homolog 1 (h-hook1) (hHK1) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9UKE5 | TNIK | S547 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKS7 | IKZF2 | S78 | ochoa | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}. |
| Q9UMD9 | COL17A1 | S61 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UPN9 | TRIM33 | S855 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPT6 | MAPK8IP3 | S364 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UPT8 | ZC3H4 | S807 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQR0 | SCML2 | S546 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y2J2 | EPB41L3 | S91 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3S1 | WNK2 | S1843 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y3S2 | ZNF330 | S27 | ochoa | Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) | None |
| Q9Y4B5 | MTCL1 | S231 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4D8 | HECTD4 | S1715 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S604 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S644 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6D6 | ARFGEF1 | S289 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6M1 | IGF2BP2 | S311 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| Q07157 | TJP1 | S1063 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q86WR0 | CCDC25 | S187 | Sugiyama | Coiled-coil domain-containing protein 25 | Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). {ECO:0000269|PubMed:32528174}. |
| P02671 | FGA | S618 | ELM | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P51858 | HDGF | S40 | Sugiyama | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| Q14152 | EIF3A | S1262 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O60828 | PQBP1 | S208 | Sugiyama | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| Q96IZ0 | PAWR | S242 | Sugiyama | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q9P0L2 | MARK1 | S382 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q6GYQ0 | RALGAPA1 | S1279 | Sugiyama | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.588850e-07 | 6.181 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.588850e-07 | 6.181 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.209257e-06 | 5.494 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.150395e-06 | 5.288 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.175867e-06 | 5.144 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.955796e-05 | 4.709 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.314125e-05 | 4.200 |
| R-HSA-68877 | Mitotic Prometaphase | 2.556469e-04 | 3.592 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.413274e-04 | 3.467 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.680949e-04 | 3.330 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 7.376416e-04 | 3.132 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 8.573899e-04 | 3.067 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.573899e-04 | 3.067 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.573899e-04 | 3.067 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 8.573899e-04 | 3.067 |
| R-HSA-68882 | Mitotic Anaphase | 6.555350e-04 | 3.183 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.798143e-04 | 3.168 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.100544e-04 | 3.041 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.383781e-03 | 2.859 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.876879e-03 | 2.727 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.570306e-03 | 2.590 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.415276e-03 | 2.617 |
| R-HSA-1640170 | Cell Cycle | 2.511466e-03 | 2.600 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.897591e-03 | 2.538 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 3.217875e-03 | 2.492 |
| R-HSA-68886 | M Phase | 3.226676e-03 | 2.491 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.442210e-03 | 2.463 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.874926e-03 | 2.412 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.244715e-03 | 2.372 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.244715e-03 | 2.372 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.043857e-03 | 2.393 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.637609e-03 | 2.334 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.836911e-03 | 2.315 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.054253e-03 | 2.296 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.054253e-03 | 2.296 |
| R-HSA-1632852 | Macroautophagy | 5.195470e-03 | 2.284 |
| R-HSA-74713 | IRS activation | 6.171739e-03 | 2.210 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 6.054841e-03 | 2.218 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 6.054841e-03 | 2.218 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.171739e-03 | 2.210 |
| R-HSA-983189 | Kinesins | 5.791800e-03 | 2.237 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.495271e-03 | 2.260 |
| R-HSA-447038 | NrCAM interactions | 6.171739e-03 | 2.210 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.349373e-03 | 2.272 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 6.970639e-03 | 2.157 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.125387e-03 | 2.147 |
| R-HSA-427975 | Proton/oligopeptide cotransporters | 7.974293e-03 | 2.098 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 7.974293e-03 | 2.098 |
| R-HSA-373753 | Nephrin family interactions | 8.570254e-03 | 2.067 |
| R-HSA-983712 | Ion channel transport | 8.382371e-03 | 2.077 |
| R-HSA-9612973 | Autophagy | 9.005919e-03 | 2.045 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 9.525377e-03 | 2.021 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 9.525377e-03 | 2.021 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.022092e-02 | 1.991 |
| R-HSA-9959399 | SLC-mediated transport of oligopeptides | 1.219363e-02 | 1.914 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.228984e-02 | 1.910 |
| R-HSA-9675135 | Diseases of DNA repair | 1.289626e-02 | 1.890 |
| R-HSA-75153 | Apoptotic execution phase | 1.289626e-02 | 1.890 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.459615e-02 | 1.836 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.459615e-02 | 1.836 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.652860e-02 | 1.782 |
| R-HSA-199991 | Membrane Trafficking | 1.630044e-02 | 1.788 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.689342e-02 | 1.772 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.718469e-02 | 1.765 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.718469e-02 | 1.765 |
| R-HSA-164843 | 2-LTR circle formation | 1.995256e-02 | 1.700 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.995256e-02 | 1.700 |
| R-HSA-74749 | Signal attenuation | 1.995256e-02 | 1.700 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.898673e-02 | 1.722 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.164965e-02 | 1.665 |
| R-HSA-182971 | EGFR downregulation | 2.407325e-02 | 1.618 |
| R-HSA-5693538 | Homology Directed Repair | 2.345494e-02 | 1.630 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 2.289324e-02 | 1.640 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.243878e-02 | 1.649 |
| R-HSA-210990 | PECAM1 interactions | 2.289324e-02 | 1.640 |
| R-HSA-162582 | Signal Transduction | 2.223413e-02 | 1.653 |
| R-HSA-5578775 | Ion homeostasis | 2.243288e-02 | 1.649 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.600037e-02 | 1.585 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.600037e-02 | 1.585 |
| R-HSA-162592 | Integration of provirus | 2.600037e-02 | 1.585 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.753040e-02 | 1.560 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.935284e-02 | 1.532 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.718981e-02 | 1.566 |
| R-HSA-877300 | Interferon gamma signaling | 2.902321e-02 | 1.537 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.977734e-02 | 1.526 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.743203e-02 | 1.562 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.123761e-02 | 1.505 |
| R-HSA-114608 | Platelet degranulation | 3.183199e-02 | 1.497 |
| R-HSA-69481 | G2/M Checkpoints | 3.183199e-02 | 1.497 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.249954e-02 | 1.488 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.249954e-02 | 1.488 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.249954e-02 | 1.488 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.249954e-02 | 1.488 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.249954e-02 | 1.488 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.726320e-02 | 1.429 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.686446e-02 | 1.433 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.625921e-02 | 1.441 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.872795e-02 | 1.412 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 3.997167e-02 | 1.398 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.997167e-02 | 1.398 |
| R-HSA-418885 | DCC mediated attractive signaling | 3.997167e-02 | 1.398 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 3.997167e-02 | 1.398 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.154367e-02 | 1.381 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.158622e-02 | 1.381 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 4.835251e-02 | 1.316 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.383828e-02 | 1.358 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.852104e-02 | 1.314 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.852104e-02 | 1.314 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 4.780210e-02 | 1.321 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.852104e-02 | 1.314 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 4.780210e-02 | 1.321 |
| R-HSA-9607240 | FLT3 Signaling | 4.615005e-02 | 1.336 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.780210e-02 | 1.321 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.650932e-02 | 1.332 |
| R-HSA-165159 | MTOR signalling | 5.095067e-02 | 1.293 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.095067e-02 | 1.293 |
| R-HSA-2028269 | Signaling by Hippo | 5.190931e-02 | 1.285 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.394669e-02 | 1.194 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.394669e-02 | 1.194 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.394669e-02 | 1.194 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.394669e-02 | 1.194 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.394669e-02 | 1.194 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.394669e-02 | 1.194 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.394669e-02 | 1.194 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.394669e-02 | 1.194 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.394669e-02 | 1.194 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.394669e-02 | 1.194 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.394669e-02 | 1.194 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 5.613758e-02 | 1.251 |
| R-HSA-912631 | Regulation of signaling by CBL | 6.048186e-02 | 1.218 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.124359e-02 | 1.213 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.124359e-02 | 1.213 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.124359e-02 | 1.213 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.124359e-02 | 1.213 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.955575e-02 | 1.225 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 5.613758e-02 | 1.251 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.343836e-02 | 1.272 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 6.048186e-02 | 1.218 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.962141e-02 | 1.225 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 5.613758e-02 | 1.251 |
| R-HSA-1500931 | Cell-Cell communication | 5.448617e-02 | 1.264 |
| R-HSA-6807004 | Negative regulation of MET activity | 6.493727e-02 | 1.188 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 7.928628e-02 | 1.101 |
| R-HSA-8941237 | Invadopodia formation | 7.928628e-02 | 1.101 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 7.928628e-02 | 1.101 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 9.437543e-02 | 1.025 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.092182e-01 | 0.962 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.092182e-01 | 0.962 |
| R-HSA-165160 | PDE3B signalling | 1.238186e-01 | 0.907 |
| R-HSA-109703 | PKB-mediated events | 1.238186e-01 | 0.907 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.238186e-01 | 0.907 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.238186e-01 | 0.907 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.238186e-01 | 0.907 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.381806e-01 | 0.860 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.381806e-01 | 0.860 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.381806e-01 | 0.860 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.381806e-01 | 0.860 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.523080e-01 | 0.817 |
| R-HSA-112412 | SOS-mediated signalling | 1.523080e-01 | 0.817 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.523080e-01 | 0.817 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.662047e-01 | 0.779 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.662047e-01 | 0.779 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.662047e-01 | 0.779 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.662047e-01 | 0.779 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.933209e-01 | 0.714 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 7.416245e-02 | 1.130 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 7.416245e-02 | 1.130 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 7.416245e-02 | 1.130 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 8.871824e-02 | 1.052 |
| R-HSA-429947 | Deadenylation of mRNA | 8.871824e-02 | 1.052 |
| R-HSA-2214320 | Anchoring fibril formation | 2.195584e-01 | 0.658 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.323566e-01 | 0.634 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.323566e-01 | 0.634 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.323566e-01 | 0.634 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.146121e-01 | 0.941 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.200009e-01 | 0.921 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.573291e-01 | 0.590 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.573291e-01 | 0.590 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.254512e-01 | 0.902 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.254512e-01 | 0.902 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.695101e-01 | 0.569 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.695101e-01 | 0.569 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.695101e-01 | 0.569 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.365226e-01 | 0.865 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.814921e-01 | 0.551 |
| R-HSA-5673000 | RAF activation | 1.478000e-01 | 0.830 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.535081e-01 | 0.814 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.932783e-01 | 0.533 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.932783e-01 | 0.533 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.048718e-01 | 0.516 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.213930e-01 | 0.916 |
| R-HSA-774815 | Nucleosome assembly | 2.184868e-01 | 0.661 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.184868e-01 | 0.661 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.513357e-01 | 0.820 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.874561e-01 | 0.727 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.670560e-01 | 0.573 |
| R-HSA-72649 | Translation initiation complex formation | 2.731438e-01 | 0.564 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.853120e-01 | 0.545 |
| R-HSA-177929 | Signaling by EGFR | 9.075161e-02 | 1.042 |
| R-HSA-3928664 | Ephrin signaling | 3.162759e-01 | 0.500 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.200009e-01 | 0.921 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.146121e-01 | 0.941 |
| R-HSA-9664873 | Pexophagy | 1.933209e-01 | 0.714 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.200009e-01 | 0.921 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.662047e-01 | 0.779 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.449457e-01 | 0.611 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.972059e-02 | 1.157 |
| R-HSA-180292 | GAB1 signalosome | 3.162759e-01 | 0.500 |
| R-HSA-166665 | Terminal pathway of complement | 1.238186e-01 | 0.907 |
| R-HSA-198203 | PI3K/AKT activation | 1.933209e-01 | 0.714 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 7.892305e-02 | 1.103 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.650481e-01 | 0.782 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.035227e-01 | 0.518 |
| R-HSA-191650 | Regulation of gap junction activity | 9.437543e-02 | 1.025 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.798744e-01 | 0.745 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.040333e-01 | 0.983 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.814921e-01 | 0.551 |
| R-HSA-9609690 | HCMV Early Events | 2.837374e-01 | 0.547 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.592584e-01 | 0.798 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.592584e-01 | 0.798 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.092182e-01 | 0.962 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 1.092182e-01 | 0.962 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.238186e-01 | 0.907 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.523080e-01 | 0.817 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.323566e-01 | 0.634 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.932783e-01 | 0.533 |
| R-HSA-112399 | IRS-mediated signalling | 2.913892e-01 | 0.536 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.156189e-01 | 0.501 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.162759e-01 | 0.500 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.650481e-01 | 0.782 |
| R-HSA-9613354 | Lipophagy | 1.798744e-01 | 0.745 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.766226e-01 | 0.558 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.885451e-01 | 0.725 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.178182e-01 | 0.929 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.798744e-01 | 0.745 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.084041e-01 | 0.681 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 7.928628e-02 | 1.101 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 9.437543e-02 | 1.025 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.238186e-01 | 0.907 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.523080e-01 | 0.817 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.798744e-01 | 0.745 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.933209e-01 | 0.714 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.933209e-01 | 0.714 |
| R-HSA-192905 | vRNP Assembly | 2.065477e-01 | 0.685 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.323566e-01 | 0.634 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.573291e-01 | 0.590 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.695101e-01 | 0.569 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.932783e-01 | 0.533 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.650481e-01 | 0.782 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.005691e-01 | 0.998 |
| R-HSA-191859 | snRNP Assembly | 1.005691e-01 | 0.998 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.162759e-01 | 0.500 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 9.526048e-02 | 1.021 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.184868e-01 | 0.661 |
| R-HSA-109704 | PI3K Cascade | 2.487968e-01 | 0.604 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.974599e-01 | 0.527 |
| R-HSA-9646399 | Aggrephagy | 1.826254e-01 | 0.738 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.316813e-02 | 1.136 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 9.374435e-02 | 1.028 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 9.374435e-02 | 1.028 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.399301e-01 | 0.854 |
| R-HSA-9620244 | Long-term potentiation | 9.374435e-02 | 1.028 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.048718e-01 | 0.516 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.162759e-01 | 0.500 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.957695e-01 | 0.708 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.136103e-02 | 1.090 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.385320e-01 | 0.622 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 1.092182e-01 | 0.962 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.573291e-01 | 0.590 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.695101e-01 | 0.569 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.421371e-01 | 0.847 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.305812e-01 | 0.637 |
| R-HSA-912446 | Meiotic recombination | 2.548808e-01 | 0.594 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.035227e-01 | 0.518 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 9.777493e-02 | 1.010 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 7.416245e-02 | 1.130 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.397769e-02 | 1.027 |
| R-HSA-9663891 | Selective autophagy | 7.854822e-02 | 1.105 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.365226e-01 | 0.865 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.826254e-01 | 0.738 |
| R-HSA-5260271 | Diseases of Immune System | 1.826254e-01 | 0.738 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.189735e-01 | 0.925 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.944908e-01 | 0.711 |
| R-HSA-3371556 | Cellular response to heat stress | 7.495627e-02 | 1.125 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.238186e-01 | 0.907 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.238186e-01 | 0.907 |
| R-HSA-2161517 | Abacavir transmembrane transport | 1.381806e-01 | 0.860 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.933209e-01 | 0.714 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.195584e-01 | 0.658 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 1.092884e-01 | 0.961 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.028961e-01 | 0.988 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.156189e-01 | 0.501 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.796272e-01 | 0.746 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.944908e-01 | 0.711 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.871458e-01 | 0.542 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.040333e-01 | 0.983 |
| R-HSA-9757110 | Prednisone ADME | 1.092884e-01 | 0.961 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.365226e-01 | 0.865 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.478000e-01 | 0.830 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.932783e-01 | 0.533 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.925496e-01 | 0.715 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.027990e-01 | 0.519 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.569004e-01 | 0.804 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 8.871824e-02 | 1.052 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.695101e-01 | 0.569 |
| R-HSA-73894 | DNA Repair | 1.803264e-01 | 0.744 |
| R-HSA-73886 | Chromosome Maintenance | 7.495627e-02 | 1.125 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 9.437543e-02 | 1.025 |
| R-HSA-8866376 | Reelin signalling pathway | 1.092182e-01 | 0.962 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.523080e-01 | 0.817 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.523080e-01 | 0.817 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.523080e-01 | 0.817 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.933209e-01 | 0.714 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 7.416245e-02 | 1.130 |
| R-HSA-166208 | mTORC1-mediated signalling | 7.892305e-02 | 1.103 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.195584e-01 | 0.658 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.449457e-01 | 0.611 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.449457e-01 | 0.611 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.814921e-01 | 0.551 |
| R-HSA-1566977 | Fibronectin matrix formation | 2.932783e-01 | 0.533 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.048718e-01 | 0.516 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.826254e-01 | 0.738 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.826254e-01 | 0.738 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.885451e-01 | 0.725 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.184971e-01 | 0.497 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.814921e-01 | 0.551 |
| R-HSA-373752 | Netrin-1 signaling | 2.124604e-01 | 0.673 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.592584e-01 | 0.798 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.168709e-01 | 0.932 |
| R-HSA-8848021 | Signaling by PTK6 | 1.142839e-01 | 0.942 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.142839e-01 | 0.942 |
| R-HSA-422475 | Axon guidance | 2.290555e-01 | 0.640 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.323566e-01 | 0.634 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.932783e-01 | 0.533 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.184868e-01 | 0.661 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.126559e-01 | 0.672 |
| R-HSA-9675108 | Nervous system development | 2.964872e-01 | 0.528 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.949108e-01 | 0.530 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.092182e-01 | 0.962 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.238186e-01 | 0.907 |
| R-HSA-164944 | Nef and signal transduction | 1.381806e-01 | 0.860 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.523080e-01 | 0.817 |
| R-HSA-448706 | Interleukin-1 processing | 1.798744e-01 | 0.745 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.798744e-01 | 0.745 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 2.065477e-01 | 0.685 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.708743e-01 | 0.767 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.245278e-01 | 0.649 |
| R-HSA-9766229 | Degradation of CDH1 | 2.427177e-01 | 0.615 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.197016e-01 | 0.658 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.960856e-01 | 0.529 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.035227e-01 | 0.518 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.591611e-01 | 0.798 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.885451e-01 | 0.725 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.711240e-01 | 0.767 |
| R-HSA-157579 | Telomere Maintenance | 2.649067e-01 | 0.577 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.510166e-01 | 0.821 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 1.040333e-01 | 0.983 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.932783e-01 | 0.533 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.767343e-01 | 0.753 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.680395e-01 | 0.572 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.048718e-01 | 0.516 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.853120e-01 | 0.545 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.216498e-01 | 0.493 |
| R-HSA-4839726 | Chromatin organization | 2.866496e-01 | 0.543 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.592584e-01 | 0.798 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.913892e-01 | 0.536 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.193660e-01 | 0.923 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.913892e-01 | 0.536 |
| R-HSA-1442490 | Collagen degradation | 3.156189e-01 | 0.501 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.193463e-01 | 0.659 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.767343e-01 | 0.753 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.944908e-01 | 0.711 |
| R-HSA-74160 | Gene expression (Transcription) | 3.059972e-01 | 0.514 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.277424e-01 | 0.894 |
| R-HSA-2586552 | Signaling by Leptin | 1.933209e-01 | 0.714 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.106310e-01 | 0.956 |
| R-HSA-2262752 | Cellular responses to stress | 2.718732e-01 | 0.566 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.274729e-01 | 0.485 |
| R-HSA-1483255 | PI Metabolism | 1.189735e-01 | 0.925 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.274729e-01 | 0.485 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.050422e-01 | 0.516 |
| R-HSA-913531 | Interferon Signaling | 1.352847e-01 | 0.869 |
| R-HSA-9754706 | Atorvastatin ADME | 2.814921e-01 | 0.551 |
| R-HSA-8853659 | RET signaling | 1.592584e-01 | 0.798 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.162759e-01 | 0.500 |
| R-HSA-446728 | Cell junction organization | 1.234402e-01 | 0.909 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.665655e-01 | 0.778 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 6.949902e-02 | 1.158 |
| R-HSA-373760 | L1CAM interactions | 1.697421e-01 | 0.770 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.200009e-01 | 0.921 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 1.535081e-01 | 0.814 |
| R-HSA-8948216 | Collagen chain trimerization | 1.650481e-01 | 0.782 |
| R-HSA-180786 | Extension of Telomeres | 3.035227e-01 | 0.518 |
| R-HSA-8983711 | OAS antiviral response | 2.323566e-01 | 0.634 |
| R-HSA-162906 | HIV Infection | 2.263719e-01 | 0.645 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.022709e-01 | 0.520 |
| R-HSA-5576891 | Cardiac conduction | 2.266460e-01 | 0.645 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.814921e-01 | 0.551 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.170506e-01 | 0.499 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.474791e-01 | 0.831 |
| R-HSA-162587 | HIV Life Cycle | 1.657448e-01 | 0.781 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 8.377641e-02 | 1.077 |
| R-HSA-1059683 | Interleukin-6 signaling | 2.449457e-01 | 0.611 |
| R-HSA-211000 | Gene Silencing by RNA | 3.140104e-01 | 0.503 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.761586e-01 | 0.754 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.124604e-01 | 0.673 |
| R-HSA-5357801 | Programmed Cell Death | 1.710007e-01 | 0.767 |
| R-HSA-109581 | Apoptosis | 1.793150e-01 | 0.746 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.162759e-01 | 0.500 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.184971e-01 | 0.497 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.274936e-01 | 0.485 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.274936e-01 | 0.485 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.274936e-01 | 0.485 |
| R-HSA-392517 | Rap1 signalling | 3.274936e-01 | 0.485 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 3.274936e-01 | 0.485 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.274936e-01 | 0.485 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.276676e-01 | 0.485 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.276676e-01 | 0.485 |
| R-HSA-373755 | Semaphorin interactions | 3.276676e-01 | 0.485 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.336710e-01 | 0.477 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.385279e-01 | 0.470 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.385279e-01 | 0.470 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 3.385279e-01 | 0.470 |
| R-HSA-445144 | Signal transduction by L1 | 3.385279e-01 | 0.470 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.396590e-01 | 0.469 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.409329e-01 | 0.467 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.456305e-01 | 0.461 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.493818e-01 | 0.457 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.493818e-01 | 0.457 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.515843e-01 | 0.454 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 3.515843e-01 | 0.454 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.539505e-01 | 0.451 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.543745e-01 | 0.451 |
| R-HSA-9679506 | SARS-CoV Infections | 3.553772e-01 | 0.449 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.575194e-01 | 0.447 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 3.575194e-01 | 0.447 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.588482e-01 | 0.445 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.600583e-01 | 0.444 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.600583e-01 | 0.444 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.705602e-01 | 0.431 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.705602e-01 | 0.431 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.705602e-01 | 0.431 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.705602e-01 | 0.431 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.705602e-01 | 0.431 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.705602e-01 | 0.431 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.730180e-01 | 0.428 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.732453e-01 | 0.428 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.752033e-01 | 0.426 |
| R-HSA-975634 | Retinoid metabolism and transport | 3.752033e-01 | 0.426 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.808905e-01 | 0.419 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.808905e-01 | 0.419 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.808905e-01 | 0.419 |
| R-HSA-200425 | Carnitine shuttle | 3.808905e-01 | 0.419 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.808905e-01 | 0.419 |
| R-HSA-3000170 | Syndecan interactions | 3.808905e-01 | 0.419 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.808905e-01 | 0.419 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.808905e-01 | 0.419 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.810544e-01 | 0.419 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.810544e-01 | 0.419 |
| R-HSA-68875 | Mitotic Prophase | 3.811420e-01 | 0.419 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.855822e-01 | 0.414 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.868822e-01 | 0.412 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.868822e-01 | 0.412 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.910518e-01 | 0.408 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.910518e-01 | 0.408 |
| R-HSA-380287 | Centrosome maturation | 3.984650e-01 | 0.400 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.984650e-01 | 0.400 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.988568e-01 | 0.399 |
| R-HSA-3000157 | Laminin interactions | 4.010469e-01 | 0.397 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.010469e-01 | 0.397 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.010469e-01 | 0.397 |
| R-HSA-194138 | Signaling by VEGF | 4.076637e-01 | 0.390 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.091860e-01 | 0.388 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.108786e-01 | 0.386 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.108786e-01 | 0.386 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.108786e-01 | 0.386 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 4.108786e-01 | 0.386 |
| R-HSA-70635 | Urea cycle | 4.108786e-01 | 0.386 |
| R-HSA-2161522 | Abacavir ADME | 4.108786e-01 | 0.386 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.108786e-01 | 0.386 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.156460e-01 | 0.381 |
| R-HSA-216083 | Integrin cell surface interactions | 4.156460e-01 | 0.381 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.156460e-01 | 0.381 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.205496e-01 | 0.376 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.205496e-01 | 0.376 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.205496e-01 | 0.376 |
| R-HSA-75109 | Triglyceride biosynthesis | 4.205496e-01 | 0.376 |
| R-HSA-1483213 | Synthesis of PE | 4.205496e-01 | 0.376 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.205496e-01 | 0.376 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.269630e-01 | 0.370 |
| R-HSA-6806834 | Signaling by MET | 4.269630e-01 | 0.370 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.300623e-01 | 0.366 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.300623e-01 | 0.366 |
| R-HSA-622312 | Inflammasomes | 4.300623e-01 | 0.366 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 4.325786e-01 | 0.364 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.394195e-01 | 0.357 |
| R-HSA-72086 | mRNA Capping | 4.394195e-01 | 0.357 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.394195e-01 | 0.357 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.486236e-01 | 0.348 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.486236e-01 | 0.348 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.486236e-01 | 0.348 |
| R-HSA-2424491 | DAP12 signaling | 4.486236e-01 | 0.348 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.486236e-01 | 0.348 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.486236e-01 | 0.348 |
| R-HSA-1500620 | Meiosis | 4.547416e-01 | 0.342 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.576771e-01 | 0.339 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.576771e-01 | 0.339 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.576771e-01 | 0.339 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.576771e-01 | 0.339 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.576771e-01 | 0.339 |
| R-HSA-109582 | Hemostasis | 4.604514e-01 | 0.337 |
| R-HSA-9609646 | HCMV Infection | 4.610352e-01 | 0.336 |
| R-HSA-163685 | Integration of energy metabolism | 4.638263e-01 | 0.334 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.665825e-01 | 0.331 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.665825e-01 | 0.331 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.680549e-01 | 0.330 |
| R-HSA-354192 | Integrin signaling | 4.753423e-01 | 0.323 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.753423e-01 | 0.323 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.753423e-01 | 0.323 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.753423e-01 | 0.323 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.753423e-01 | 0.323 |
| R-HSA-9930044 | Nuclear RNA decay | 4.753423e-01 | 0.323 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.753423e-01 | 0.323 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.753423e-01 | 0.323 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.753423e-01 | 0.323 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.764022e-01 | 0.322 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.770724e-01 | 0.321 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.839587e-01 | 0.315 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.870356e-01 | 0.312 |
| R-HSA-203615 | eNOS activation | 4.924341e-01 | 0.308 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.924341e-01 | 0.308 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.924341e-01 | 0.308 |
| R-HSA-5365859 | RA biosynthesis pathway | 4.924341e-01 | 0.308 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.924341e-01 | 0.308 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.931052e-01 | 0.307 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.007709e-01 | 0.300 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.078945e-01 | 0.294 |
| R-HSA-3371511 | HSF1 activation | 5.089712e-01 | 0.293 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.089712e-01 | 0.293 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 5.089712e-01 | 0.293 |
| R-HSA-1474290 | Collagen formation | 5.130226e-01 | 0.290 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.170373e-01 | 0.286 |
| R-HSA-1474244 | Extracellular matrix organization | 5.228200e-01 | 0.282 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.249714e-01 | 0.280 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.249714e-01 | 0.280 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.249714e-01 | 0.280 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.295525e-01 | 0.276 |
| R-HSA-69541 | Stabilization of p53 | 5.327757e-01 | 0.273 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.327757e-01 | 0.273 |
| R-HSA-71336 | Pentose phosphate pathway | 5.327757e-01 | 0.273 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.327757e-01 | 0.273 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.327757e-01 | 0.273 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.331807e-01 | 0.273 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.335123e-01 | 0.273 |
| R-HSA-397014 | Muscle contraction | 5.343343e-01 | 0.272 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.377098e-01 | 0.269 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.404522e-01 | 0.267 |
| R-HSA-3371568 | Attenuation phase | 5.404522e-01 | 0.267 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.404522e-01 | 0.267 |
| R-HSA-3214847 | HATs acetylate histones | 5.430446e-01 | 0.265 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.430446e-01 | 0.265 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.430446e-01 | 0.265 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.452786e-01 | 0.263 |
| R-HSA-70171 | Glycolysis | 5.479221e-01 | 0.261 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.479221e-01 | 0.261 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.480030e-01 | 0.261 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.480030e-01 | 0.261 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.480030e-01 | 0.261 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.527632e-01 | 0.257 |
| R-HSA-418990 | Adherens junctions interactions | 5.544008e-01 | 0.256 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.554303e-01 | 0.255 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.575678e-01 | 0.254 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.627359e-01 | 0.250 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.699220e-01 | 0.244 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.699220e-01 | 0.244 |
| R-HSA-2172127 | DAP12 interactions | 5.769903e-01 | 0.239 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.769903e-01 | 0.239 |
| R-HSA-375280 | Amine ligand-binding receptors | 5.769903e-01 | 0.239 |
| R-HSA-9907900 | Proteasome assembly | 5.769903e-01 | 0.239 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.804283e-01 | 0.236 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.839430e-01 | 0.234 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.839430e-01 | 0.234 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.839430e-01 | 0.234 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.901687e-01 | 0.229 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.901687e-01 | 0.229 |
| R-HSA-5619102 | SLC transporter disorders | 5.905695e-01 | 0.229 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.907818e-01 | 0.229 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.907818e-01 | 0.229 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.907818e-01 | 0.229 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.907818e-01 | 0.229 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.946780e-01 | 0.226 |
| R-HSA-1483257 | Phospholipid metabolism | 5.964378e-01 | 0.224 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.964378e-01 | 0.224 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.975086e-01 | 0.224 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.975086e-01 | 0.224 |
| R-HSA-437239 | Recycling pathway of L1 | 5.975086e-01 | 0.224 |
| R-HSA-1483191 | Synthesis of PC | 5.975086e-01 | 0.224 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.991503e-01 | 0.222 |
| R-HSA-5620924 | Intraflagellar transport | 6.041252e-01 | 0.219 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.041252e-01 | 0.219 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.055708e-01 | 0.218 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.085662e-01 | 0.216 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.106334e-01 | 0.214 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.106334e-01 | 0.214 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.106334e-01 | 0.214 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.156164e-01 | 0.211 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.156164e-01 | 0.211 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.170351e-01 | 0.210 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.170351e-01 | 0.210 |
| R-HSA-9748787 | Azathioprine ADME | 6.170351e-01 | 0.210 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.233319e-01 | 0.205 |
| R-HSA-9824446 | Viral Infection Pathways | 6.248209e-01 | 0.204 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.295255e-01 | 0.201 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.295255e-01 | 0.201 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.295255e-01 | 0.201 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.295255e-01 | 0.201 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.295255e-01 | 0.201 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.295255e-01 | 0.201 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.295255e-01 | 0.201 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.333021e-01 | 0.198 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.335959e-01 | 0.198 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.335959e-01 | 0.198 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.356177e-01 | 0.197 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.356177e-01 | 0.197 |
| R-HSA-168255 | Influenza Infection | 6.362514e-01 | 0.196 |
| R-HSA-70326 | Glucose metabolism | 6.377357e-01 | 0.195 |
| R-HSA-2559583 | Cellular Senescence | 6.396148e-01 | 0.194 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.459053e-01 | 0.190 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.459053e-01 | 0.190 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.475042e-01 | 0.189 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.475042e-01 | 0.189 |
| R-HSA-9753281 | Paracetamol ADME | 6.475042e-01 | 0.189 |
| R-HSA-418597 | G alpha (z) signalling events | 6.475042e-01 | 0.189 |
| R-HSA-9012852 | Signaling by NOTCH3 | 6.475042e-01 | 0.189 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.533018e-01 | 0.185 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.533018e-01 | 0.185 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.533018e-01 | 0.185 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.533018e-01 | 0.185 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.533018e-01 | 0.185 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.533018e-01 | 0.185 |
| R-HSA-421270 | Cell-cell junction organization | 6.558649e-01 | 0.183 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.578864e-01 | 0.182 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.578864e-01 | 0.182 |
| R-HSA-5621480 | Dectin-2 family | 6.590044e-01 | 0.181 |
| R-HSA-69275 | G2/M Transition | 6.593377e-01 | 0.181 |
| R-HSA-8953854 | Metabolism of RNA | 6.608408e-01 | 0.180 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.618077e-01 | 0.179 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.646136e-01 | 0.177 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.646136e-01 | 0.177 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.657373e-01 | 0.177 |
| R-HSA-8979227 | Triglyceride metabolism | 6.701308e-01 | 0.174 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.704093e-01 | 0.174 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.733555e-01 | 0.172 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.733555e-01 | 0.172 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.733555e-01 | 0.172 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.755576e-01 | 0.170 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.755576e-01 | 0.170 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.755576e-01 | 0.170 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 6.755576e-01 | 0.170 |
| R-HSA-6798695 | Neutrophil degranulation | 6.773333e-01 | 0.169 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.844111e-01 | 0.165 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.861458e-01 | 0.164 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.861458e-01 | 0.164 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.861458e-01 | 0.164 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.861458e-01 | 0.164 |
| R-HSA-9707616 | Heme signaling | 6.861458e-01 | 0.164 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.861458e-01 | 0.164 |
| R-HSA-382551 | Transport of small molecules | 6.890237e-01 | 0.162 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.904610e-01 | 0.161 |
| R-HSA-1280218 | Adaptive Immune System | 6.905553e-01 | 0.161 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.913101e-01 | 0.160 |
| R-HSA-1474165 | Reproduction | 6.954924e-01 | 0.158 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.963897e-01 | 0.157 |
| R-HSA-112316 | Neuronal System | 6.998549e-01 | 0.155 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.025917e-01 | 0.153 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.063005e-01 | 0.151 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.152576e-01 | 0.146 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 7.158890e-01 | 0.145 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.158890e-01 | 0.145 |
| R-HSA-5218859 | Regulated Necrosis | 7.158890e-01 | 0.145 |
| R-HSA-167172 | Transcription of the HIV genome | 7.158890e-01 | 0.145 |
| R-HSA-72172 | mRNA Splicing | 7.166114e-01 | 0.145 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.251655e-01 | 0.140 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.251655e-01 | 0.140 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.296900e-01 | 0.137 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.296900e-01 | 0.137 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.296900e-01 | 0.137 |
| R-HSA-8978934 | Metabolism of cofactors | 7.296900e-01 | 0.137 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.296900e-01 | 0.137 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.383981e-01 | 0.132 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.385175e-01 | 0.132 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.385175e-01 | 0.132 |
| R-HSA-449147 | Signaling by Interleukins | 7.427889e-01 | 0.129 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.428230e-01 | 0.129 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.428230e-01 | 0.129 |
| R-HSA-8852135 | Protein ubiquitination | 7.470579e-01 | 0.127 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.470579e-01 | 0.127 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.470579e-01 | 0.127 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.512232e-01 | 0.124 |
| R-HSA-9748784 | Drug ADME | 7.538555e-01 | 0.123 |
| R-HSA-2187338 | Visual phototransduction | 7.575286e-01 | 0.121 |
| R-HSA-212436 | Generic Transcription Pathway | 7.599207e-01 | 0.119 |
| R-HSA-166520 | Signaling by NTRKs | 7.604707e-01 | 0.119 |
| R-HSA-9659379 | Sensory processing of sound | 7.633137e-01 | 0.117 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.672124e-01 | 0.115 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.672124e-01 | 0.115 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.672124e-01 | 0.115 |
| R-HSA-977225 | Amyloid fiber formation | 7.710470e-01 | 0.113 |
| R-HSA-69306 | DNA Replication | 7.747226e-01 | 0.111 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.774828e-01 | 0.109 |
| R-HSA-73887 | Death Receptor Signaling | 7.774828e-01 | 0.109 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.785286e-01 | 0.109 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.821775e-01 | 0.107 |
| R-HSA-9610379 | HCMV Late Events | 7.855872e-01 | 0.105 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.882307e-01 | 0.103 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.892966e-01 | 0.103 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.892966e-01 | 0.103 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.934318e-01 | 0.100 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.028469e-01 | 0.095 |
| R-HSA-73884 | Base Excision Repair | 8.060966e-01 | 0.094 |
| R-HSA-202424 | Downstream TCR signaling | 8.060966e-01 | 0.094 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.155289e-01 | 0.089 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.184749e-01 | 0.087 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.185703e-01 | 0.087 |
| R-HSA-2029481 | FCGR activation | 8.185703e-01 | 0.087 |
| R-HSA-72306 | tRNA processing | 8.200710e-01 | 0.086 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.245715e-01 | 0.084 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.273979e-01 | 0.082 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.289709e-01 | 0.081 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.302443e-01 | 0.081 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.302443e-01 | 0.081 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.311332e-01 | 0.080 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.330440e-01 | 0.079 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.353662e-01 | 0.078 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.357976e-01 | 0.078 |
| R-HSA-190236 | Signaling by FGFR | 8.357976e-01 | 0.078 |
| R-HSA-422356 | Regulation of insulin secretion | 8.357976e-01 | 0.078 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.357976e-01 | 0.078 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.357976e-01 | 0.078 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.357976e-01 | 0.078 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.385060e-01 | 0.076 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.437900e-01 | 0.074 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.463670e-01 | 0.072 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.475557e-01 | 0.072 |
| R-HSA-416476 | G alpha (q) signalling events | 8.492317e-01 | 0.071 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.513947e-01 | 0.070 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.538468e-01 | 0.069 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.538468e-01 | 0.069 |
| R-HSA-9833110 | RSV-host interactions | 8.538468e-01 | 0.069 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.557773e-01 | 0.068 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.562585e-01 | 0.067 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.577243e-01 | 0.067 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.586306e-01 | 0.066 |
| R-HSA-5617833 | Cilium Assembly | 8.607400e-01 | 0.065 |
| R-HSA-69239 | Synthesis of DNA | 8.609637e-01 | 0.065 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.609637e-01 | 0.065 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.609637e-01 | 0.065 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.632584e-01 | 0.064 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.632584e-01 | 0.064 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.643088e-01 | 0.063 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.655154e-01 | 0.063 |
| R-HSA-202403 | TCR signaling | 8.677352e-01 | 0.062 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.762556e-01 | 0.057 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.777633e-01 | 0.057 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.782988e-01 | 0.056 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.803084e-01 | 0.055 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.824845e-01 | 0.054 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.861410e-01 | 0.052 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.861410e-01 | 0.052 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.986727e-01 | 0.046 |
| R-HSA-977606 | Regulation of Complement cascade | 9.003470e-01 | 0.046 |
| R-HSA-69206 | G1/S Transition | 9.019938e-01 | 0.045 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.036134e-01 | 0.044 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.067731e-01 | 0.043 |
| R-HSA-9909396 | Circadian clock | 9.142283e-01 | 0.039 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.207493e-01 | 0.036 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.210893e-01 | 0.036 |
| R-HSA-168256 | Immune System | 9.218667e-01 | 0.035 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.235262e-01 | 0.035 |
| R-HSA-6807070 | PTEN Regulation | 9.249405e-01 | 0.034 |
| R-HSA-9664407 | Parasite infection | 9.261822e-01 | 0.033 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 9.261822e-01 | 0.033 |
| R-HSA-9664417 | Leishmania phagocytosis | 9.261822e-01 | 0.033 |
| R-HSA-8939211 | ESR-mediated signaling | 9.264040e-01 | 0.033 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.264040e-01 | 0.033 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.274034e-01 | 0.033 |
| R-HSA-166658 | Complement cascade | 9.332140e-01 | 0.030 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.343193e-01 | 0.030 |
| R-HSA-69242 | S Phase | 9.364755e-01 | 0.029 |
| R-HSA-9758941 | Gastrulation | 9.375270e-01 | 0.028 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.385611e-01 | 0.028 |
| R-HSA-2142753 | Arachidonate metabolism | 9.405786e-01 | 0.027 |
| R-HSA-5688426 | Deubiquitination | 9.424591e-01 | 0.026 |
| R-HSA-5663205 | Infectious disease | 9.441834e-01 | 0.025 |
| R-HSA-9711097 | Cellular response to starvation | 9.462434e-01 | 0.024 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.529542e-01 | 0.021 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.535329e-01 | 0.021 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.567385e-01 | 0.019 |
| R-HSA-418555 | G alpha (s) signalling events | 9.574557e-01 | 0.019 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.588546e-01 | 0.018 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.588546e-01 | 0.018 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.588546e-01 | 0.018 |
| R-HSA-1266738 | Developmental Biology | 9.588757e-01 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.598984e-01 | 0.018 |
| R-HSA-9658195 | Leishmania infection | 9.598984e-01 | 0.018 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.604563e-01 | 0.018 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.638004e-01 | 0.016 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.651908e-01 | 0.015 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.668612e-01 | 0.015 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.679844e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.696774e-01 | 0.013 |
| R-HSA-428157 | Sphingolipid metabolism | 9.742458e-01 | 0.011 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.750942e-01 | 0.011 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.750942e-01 | 0.011 |
| R-HSA-6805567 | Keratinization | 9.767084e-01 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 9.782060e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.784968e-01 | 0.009 |
| R-HSA-168249 | Innate Immune System | 9.800496e-01 | 0.009 |
| R-HSA-1643685 | Disease | 9.818300e-01 | 0.008 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.841610e-01 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 9.846773e-01 | 0.007 |
| R-HSA-72312 | rRNA processing | 9.849386e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.857138e-01 | 0.006 |
| R-HSA-157118 | Signaling by NOTCH | 9.868312e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.910314e-01 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 9.936153e-01 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 9.936153e-01 | 0.003 |
| R-HSA-195721 | Signaling by WNT | 9.950358e-01 | 0.002 |
| R-HSA-72766 | Translation | 9.954014e-01 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.990367e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.999394e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999561e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999654e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999790e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.840 | 0.214 | 2 | 0.851 |
BMPR1B |
0.837 | 0.406 | 1 | 0.507 |
CDC7 |
0.834 | 0.215 | 1 | 0.379 |
CLK3 |
0.828 | 0.099 | 1 | 0.270 |
GRK1 |
0.824 | 0.189 | -2 | 0.836 |
DSTYK |
0.823 | 0.077 | 2 | 0.855 |
MOS |
0.821 | 0.117 | 1 | 0.315 |
GRK6 |
0.821 | 0.237 | 1 | 0.390 |
RSK2 |
0.820 | 0.139 | -3 | 0.787 |
KIS |
0.820 | 0.013 | 1 | 0.179 |
MTOR |
0.820 | -0.017 | 1 | 0.238 |
GRK7 |
0.819 | 0.189 | 1 | 0.343 |
BMPR1A |
0.819 | 0.314 | 1 | 0.486 |
GCN2 |
0.819 | -0.052 | 2 | 0.790 |
PIM3 |
0.819 | 0.080 | -3 | 0.846 |
TGFBR1 |
0.819 | 0.249 | -2 | 0.849 |
IKKB |
0.818 | -0.027 | -2 | 0.767 |
NDR2 |
0.816 | 0.065 | -3 | 0.836 |
GRK2 |
0.816 | 0.315 | -2 | 0.780 |
GRK5 |
0.815 | 0.144 | -3 | 0.866 |
RAF1 |
0.815 | 0.010 | 1 | 0.288 |
ACVR2A |
0.815 | 0.306 | -2 | 0.843 |
ACVR2B |
0.815 | 0.301 | -2 | 0.852 |
CAMK2G |
0.815 | 0.036 | 2 | 0.816 |
TGFBR2 |
0.814 | 0.087 | -2 | 0.859 |
TBK1 |
0.813 | -0.104 | 1 | 0.210 |
CAMK1B |
0.813 | 0.066 | -3 | 0.862 |
PRPK |
0.812 | -0.050 | -1 | 0.856 |
PLK1 |
0.812 | 0.208 | -2 | 0.851 |
ALK4 |
0.812 | 0.218 | -2 | 0.871 |
CK2A2 |
0.812 | 0.243 | 1 | 0.457 |
SKMLCK |
0.812 | 0.131 | -2 | 0.881 |
IKKE |
0.811 | -0.104 | 1 | 0.211 |
NLK |
0.810 | -0.014 | 1 | 0.256 |
P90RSK |
0.810 | 0.091 | -3 | 0.798 |
NEK6 |
0.810 | -0.024 | -2 | 0.888 |
SRPK1 |
0.810 | 0.043 | -3 | 0.782 |
DRAK1 |
0.810 | 0.352 | 1 | 0.500 |
ATR |
0.809 | -0.042 | 1 | 0.245 |
BMPR2 |
0.809 | 0.012 | -2 | 0.899 |
MST4 |
0.809 | 0.017 | 2 | 0.826 |
IKKA |
0.809 | 0.027 | -2 | 0.755 |
ULK2 |
0.809 | -0.099 | 2 | 0.770 |
NEK7 |
0.809 | -0.058 | -3 | 0.833 |
CDK1 |
0.808 | 0.014 | 1 | 0.237 |
GRK4 |
0.808 | 0.070 | -2 | 0.885 |
PDHK4 |
0.808 | -0.122 | 1 | 0.269 |
NDR1 |
0.807 | 0.032 | -3 | 0.829 |
RSK3 |
0.807 | 0.058 | -3 | 0.784 |
ALK2 |
0.807 | 0.182 | -2 | 0.867 |
CDKL1 |
0.807 | 0.033 | -3 | 0.827 |
CAMK2B |
0.807 | 0.109 | 2 | 0.785 |
MAPKAPK2 |
0.807 | 0.074 | -3 | 0.737 |
PKN3 |
0.807 | 0.003 | -3 | 0.830 |
DAPK2 |
0.806 | 0.149 | -3 | 0.869 |
PKN2 |
0.806 | 0.044 | -3 | 0.823 |
GRK3 |
0.806 | 0.261 | -2 | 0.752 |
RSK4 |
0.806 | 0.138 | -3 | 0.754 |
CLK2 |
0.806 | 0.116 | -3 | 0.763 |
HUNK |
0.806 | 0.011 | 2 | 0.778 |
CK2A1 |
0.805 | 0.249 | 1 | 0.480 |
PIM1 |
0.805 | 0.057 | -3 | 0.789 |
MLK1 |
0.805 | -0.033 | 2 | 0.792 |
ERK5 |
0.804 | -0.063 | 1 | 0.228 |
LATS2 |
0.804 | 0.029 | -5 | 0.744 |
CAMLCK |
0.804 | 0.065 | -2 | 0.877 |
MSK2 |
0.804 | 0.067 | -3 | 0.773 |
PRKD1 |
0.803 | 0.000 | -3 | 0.832 |
DLK |
0.803 | 0.094 | 1 | 0.329 |
PKCD |
0.803 | 0.026 | 2 | 0.770 |
PKACG |
0.803 | 0.043 | -2 | 0.775 |
CDK8 |
0.803 | -0.046 | 1 | 0.190 |
NIK |
0.803 | -0.002 | -3 | 0.870 |
SRPK2 |
0.802 | 0.045 | -3 | 0.708 |
NUAK2 |
0.802 | 0.033 | -3 | 0.831 |
ULK1 |
0.802 | -0.080 | -3 | 0.808 |
AURC |
0.802 | 0.086 | -2 | 0.711 |
MSK1 |
0.801 | 0.111 | -3 | 0.769 |
DYRK2 |
0.801 | -0.009 | 1 | 0.198 |
WNK1 |
0.801 | -0.043 | -2 | 0.864 |
CAMK2A |
0.801 | 0.110 | 2 | 0.799 |
P70S6KB |
0.801 | 0.055 | -3 | 0.799 |
ATM |
0.801 | -0.035 | 1 | 0.225 |
CAMK2D |
0.801 | 0.011 | -3 | 0.837 |
FAM20C |
0.801 | 0.015 | 2 | 0.572 |
PRKD2 |
0.800 | 0.020 | -3 | 0.763 |
RIPK3 |
0.800 | -0.047 | 3 | 0.718 |
P38G |
0.800 | -0.016 | 1 | 0.184 |
HIPK4 |
0.800 | -0.027 | 1 | 0.216 |
MARK4 |
0.800 | -0.003 | 4 | 0.843 |
CHAK2 |
0.800 | -0.044 | -1 | 0.833 |
PDHK1 |
0.800 | -0.189 | 1 | 0.236 |
CDK18 |
0.800 | -0.017 | 1 | 0.181 |
JNK2 |
0.799 | -0.009 | 1 | 0.189 |
MAPKAPK3 |
0.799 | 0.015 | -3 | 0.777 |
AURA |
0.799 | 0.103 | -2 | 0.705 |
LATS1 |
0.799 | 0.086 | -3 | 0.859 |
CDK19 |
0.799 | -0.046 | 1 | 0.177 |
PKACB |
0.799 | 0.091 | -2 | 0.723 |
PRKX |
0.799 | 0.113 | -3 | 0.673 |
CLK4 |
0.798 | 0.061 | -3 | 0.777 |
BCKDK |
0.798 | -0.101 | -1 | 0.835 |
HIPK2 |
0.798 | 0.002 | 1 | 0.170 |
CDKL5 |
0.798 | -0.006 | -3 | 0.821 |
SRPK3 |
0.798 | 0.044 | -3 | 0.758 |
AMPKA1 |
0.798 | -0.006 | -3 | 0.839 |
JNK3 |
0.798 | -0.019 | 1 | 0.189 |
ICK |
0.797 | 0.004 | -3 | 0.856 |
TTBK2 |
0.796 | -0.090 | 2 | 0.687 |
CDK17 |
0.796 | -0.025 | 1 | 0.186 |
CDK13 |
0.796 | -0.043 | 1 | 0.183 |
PAK1 |
0.795 | 0.020 | -2 | 0.807 |
MLK3 |
0.795 | -0.004 | 2 | 0.723 |
PLK3 |
0.795 | 0.025 | 2 | 0.755 |
CDK5 |
0.795 | -0.013 | 1 | 0.206 |
PKCB |
0.794 | 0.021 | 2 | 0.718 |
NEK9 |
0.794 | -0.116 | 2 | 0.814 |
CLK1 |
0.794 | 0.046 | -3 | 0.745 |
TSSK2 |
0.794 | 0.009 | -5 | 0.823 |
NIM1 |
0.794 | -0.028 | 3 | 0.762 |
CDK3 |
0.794 | -0.009 | 1 | 0.189 |
ANKRD3 |
0.794 | -0.058 | 1 | 0.268 |
PKCG |
0.793 | 0.025 | 2 | 0.716 |
MLK4 |
0.792 | 0.017 | 2 | 0.706 |
CDK12 |
0.792 | -0.038 | 1 | 0.176 |
ERK1 |
0.792 | -0.041 | 1 | 0.164 |
CAMK4 |
0.792 | -0.019 | -3 | 0.804 |
TLK2 |
0.792 | -0.038 | 1 | 0.235 |
MYLK4 |
0.791 | 0.098 | -2 | 0.818 |
RIPK1 |
0.791 | -0.101 | 1 | 0.258 |
AMPKA2 |
0.791 | -0.010 | -3 | 0.806 |
DNAPK |
0.791 | -0.054 | 1 | 0.157 |
DYRK4 |
0.791 | -0.006 | 1 | 0.183 |
PKR |
0.791 | -0.041 | 1 | 0.249 |
AURB |
0.791 | 0.060 | -2 | 0.713 |
HIPK1 |
0.791 | 0.007 | 1 | 0.201 |
PASK |
0.791 | 0.196 | -3 | 0.860 |
CDK2 |
0.791 | -0.007 | 1 | 0.276 |
WNK3 |
0.791 | -0.171 | 1 | 0.228 |
TSSK1 |
0.791 | -0.009 | -3 | 0.858 |
PKCA |
0.790 | 0.015 | 2 | 0.709 |
CDK7 |
0.790 | -0.059 | 1 | 0.197 |
MASTL |
0.790 | -0.125 | -2 | 0.812 |
IRE1 |
0.790 | -0.087 | 1 | 0.222 |
MEK1 |
0.790 | 0.044 | 2 | 0.820 |
P38B |
0.790 | -0.034 | 1 | 0.177 |
YSK4 |
0.790 | -0.061 | 1 | 0.260 |
BRSK1 |
0.789 | 0.052 | -3 | 0.788 |
PAK3 |
0.789 | -0.027 | -2 | 0.801 |
CDK16 |
0.789 | -0.011 | 1 | 0.178 |
PKCH |
0.789 | 0.004 | 2 | 0.703 |
DYRK1B |
0.788 | -0.002 | 1 | 0.203 |
PAK6 |
0.788 | 0.024 | -2 | 0.739 |
P38A |
0.788 | -0.042 | 1 | 0.193 |
QSK |
0.787 | 0.018 | 4 | 0.818 |
MNK2 |
0.787 | -0.004 | -2 | 0.811 |
SGK3 |
0.787 | 0.040 | -3 | 0.764 |
MEKK3 |
0.787 | 0.023 | 1 | 0.292 |
CDK14 |
0.786 | -0.009 | 1 | 0.200 |
AKT2 |
0.786 | 0.057 | -3 | 0.702 |
PAK2 |
0.786 | -0.002 | -2 | 0.797 |
ERK2 |
0.786 | -0.053 | 1 | 0.192 |
CK1E |
0.785 | 0.072 | -3 | 0.585 |
PKG2 |
0.785 | 0.037 | -2 | 0.712 |
MLK2 |
0.785 | -0.141 | 2 | 0.804 |
MARK3 |
0.785 | 0.041 | 4 | 0.780 |
QIK |
0.785 | -0.031 | -3 | 0.824 |
PRKD3 |
0.784 | -0.007 | -3 | 0.750 |
CAMK1G |
0.784 | 0.015 | -3 | 0.764 |
MNK1 |
0.784 | -0.002 | -2 | 0.821 |
PLK4 |
0.783 | -0.066 | 2 | 0.640 |
CDK9 |
0.783 | -0.065 | 1 | 0.182 |
MST3 |
0.783 | 0.057 | 2 | 0.806 |
MELK |
0.783 | -0.040 | -3 | 0.793 |
NEK2 |
0.783 | -0.114 | 2 | 0.792 |
JNK1 |
0.782 | -0.014 | 1 | 0.204 |
MARK2 |
0.782 | 0.024 | 4 | 0.740 |
SMG1 |
0.782 | -0.100 | 1 | 0.204 |
DYRK1A |
0.782 | -0.013 | 1 | 0.200 |
PKCZ |
0.782 | -0.052 | 2 | 0.758 |
CDK10 |
0.782 | -0.004 | 1 | 0.197 |
NUAK1 |
0.782 | -0.035 | -3 | 0.781 |
BRAF |
0.782 | 0.010 | -4 | 0.864 |
SIK |
0.781 | -0.009 | -3 | 0.758 |
DYRK3 |
0.781 | 0.013 | 1 | 0.194 |
IRE2 |
0.781 | -0.096 | 2 | 0.741 |
P38D |
0.781 | -0.041 | 1 | 0.127 |
ZAK |
0.781 | -0.050 | 1 | 0.267 |
VRK2 |
0.781 | -0.172 | 1 | 0.253 |
MAPKAPK5 |
0.781 | -0.046 | -3 | 0.745 |
PKACA |
0.781 | 0.068 | -2 | 0.672 |
DCAMKL1 |
0.781 | 0.004 | -3 | 0.773 |
TLK1 |
0.781 | -0.065 | -2 | 0.880 |
CHAK1 |
0.780 | -0.123 | 2 | 0.760 |
PIM2 |
0.780 | 0.035 | -3 | 0.755 |
PHKG1 |
0.780 | -0.080 | -3 | 0.817 |
DAPK1 |
0.780 | 0.170 | -3 | 0.787 |
MARK1 |
0.780 | 0.033 | 4 | 0.803 |
PERK |
0.779 | -0.095 | -2 | 0.874 |
TAO3 |
0.779 | 0.013 | 1 | 0.272 |
DAPK3 |
0.778 | 0.117 | -3 | 0.798 |
HIPK3 |
0.778 | -0.032 | 1 | 0.173 |
PRP4 |
0.778 | -0.010 | -3 | 0.784 |
SMMLCK |
0.777 | 0.072 | -3 | 0.821 |
CK1D |
0.777 | 0.063 | -3 | 0.535 |
MEKK2 |
0.777 | -0.051 | 2 | 0.786 |
BRSK2 |
0.776 | -0.053 | -3 | 0.804 |
MEKK1 |
0.776 | -0.112 | 1 | 0.229 |
CK1G1 |
0.776 | -0.006 | -3 | 0.588 |
AKT1 |
0.776 | 0.040 | -3 | 0.711 |
MEK5 |
0.775 | -0.094 | 2 | 0.806 |
CK1A2 |
0.775 | 0.065 | -3 | 0.534 |
PKCT |
0.775 | -0.023 | 2 | 0.715 |
GCK |
0.774 | 0.092 | 1 | 0.315 |
CHK1 |
0.774 | -0.045 | -3 | 0.808 |
GSK3A |
0.774 | 0.029 | 4 | 0.506 |
HRI |
0.773 | -0.145 | -2 | 0.878 |
PLK2 |
0.773 | 0.038 | -3 | 0.798 |
PINK1 |
0.773 | -0.132 | 1 | 0.224 |
GAK |
0.773 | 0.008 | 1 | 0.270 |
NEK5 |
0.773 | -0.114 | 1 | 0.229 |
SNRK |
0.772 | -0.107 | 2 | 0.697 |
P70S6K |
0.772 | 0.013 | -3 | 0.721 |
GSK3B |
0.771 | 0.017 | 4 | 0.495 |
WNK4 |
0.771 | -0.108 | -2 | 0.849 |
NEK8 |
0.771 | -0.065 | 2 | 0.799 |
MPSK1 |
0.770 | -0.057 | 1 | 0.198 |
PAK5 |
0.770 | -0.002 | -2 | 0.676 |
DCAMKL2 |
0.770 | -0.032 | -3 | 0.793 |
PKCE |
0.770 | 0.032 | 2 | 0.697 |
CAMK1D |
0.769 | 0.027 | -3 | 0.689 |
MST2 |
0.769 | -0.002 | 1 | 0.281 |
PKCI |
0.768 | -0.018 | 2 | 0.720 |
TTBK1 |
0.768 | -0.127 | 2 | 0.607 |
PHKG2 |
0.768 | -0.071 | -3 | 0.775 |
NEK11 |
0.768 | -0.053 | 1 | 0.276 |
CAMKK1 |
0.768 | -0.083 | -2 | 0.757 |
PAK4 |
0.767 | 0.006 | -2 | 0.691 |
HPK1 |
0.767 | 0.050 | 1 | 0.304 |
CDK6 |
0.767 | -0.042 | 1 | 0.170 |
IRAK4 |
0.766 | -0.140 | 1 | 0.205 |
TAK1 |
0.765 | -0.013 | 1 | 0.267 |
SGK1 |
0.765 | 0.058 | -3 | 0.632 |
CDK4 |
0.765 | -0.045 | 1 | 0.170 |
MAK |
0.764 | 0.015 | -2 | 0.698 |
MINK |
0.764 | -0.030 | 1 | 0.250 |
TAO2 |
0.764 | -0.068 | 2 | 0.827 |
TNIK |
0.764 | -0.021 | 3 | 0.852 |
SSTK |
0.764 | -0.054 | 4 | 0.810 |
EEF2K |
0.763 | -0.024 | 3 | 0.832 |
PDK1 |
0.763 | -0.079 | 1 | 0.224 |
AKT3 |
0.763 | 0.047 | -3 | 0.647 |
CAMKK2 |
0.761 | -0.094 | -2 | 0.745 |
HGK |
0.761 | -0.064 | 3 | 0.848 |
MAP3K15 |
0.760 | -0.084 | 1 | 0.236 |
KHS2 |
0.760 | 0.029 | 1 | 0.270 |
ERK7 |
0.760 | -0.046 | 2 | 0.523 |
LKB1 |
0.759 | -0.106 | -3 | 0.823 |
PKN1 |
0.759 | -0.021 | -3 | 0.731 |
MEKK6 |
0.759 | -0.080 | 1 | 0.236 |
MST1 |
0.758 | -0.051 | 1 | 0.263 |
MRCKA |
0.758 | 0.022 | -3 | 0.750 |
CHK2 |
0.758 | 0.024 | -3 | 0.644 |
VRK1 |
0.758 | -0.071 | 2 | 0.821 |
NEK4 |
0.757 | -0.143 | 1 | 0.218 |
MOK |
0.757 | -0.008 | 1 | 0.192 |
KHS1 |
0.757 | -0.028 | 1 | 0.237 |
ROCK2 |
0.757 | 0.025 | -3 | 0.783 |
MRCKB |
0.756 | 0.018 | -3 | 0.734 |
STK33 |
0.755 | -0.095 | 2 | 0.598 |
CK1A |
0.754 | 0.108 | -3 | 0.447 |
PDHK3_TYR |
0.754 | 0.177 | 4 | 0.927 |
IRAK1 |
0.753 | -0.192 | -1 | 0.768 |
CAMK1A |
0.753 | 0.009 | -3 | 0.655 |
NEK1 |
0.753 | -0.131 | 1 | 0.221 |
LRRK2 |
0.753 | -0.112 | 2 | 0.826 |
BUB1 |
0.752 | -0.013 | -5 | 0.787 |
LOK |
0.752 | -0.098 | -2 | 0.756 |
YSK1 |
0.752 | -0.078 | 2 | 0.785 |
OSR1 |
0.751 | -0.006 | 2 | 0.775 |
TTK |
0.750 | 0.008 | -2 | 0.877 |
SLK |
0.749 | -0.089 | -2 | 0.703 |
DMPK1 |
0.749 | 0.046 | -3 | 0.747 |
RIPK2 |
0.749 | -0.164 | 1 | 0.233 |
PDHK4_TYR |
0.749 | 0.132 | 2 | 0.865 |
BMPR2_TYR |
0.748 | 0.198 | -1 | 0.854 |
MEK2 |
0.748 | -0.127 | 2 | 0.801 |
HASPIN |
0.747 | -0.019 | -1 | 0.721 |
PBK |
0.747 | -0.088 | 1 | 0.194 |
MAP2K6_TYR |
0.746 | 0.156 | -1 | 0.874 |
TXK |
0.745 | 0.291 | 1 | 0.431 |
ROCK1 |
0.744 | 0.014 | -3 | 0.747 |
YANK3 |
0.744 | -0.018 | 2 | 0.387 |
PKG1 |
0.744 | -0.008 | -2 | 0.624 |
PDHK1_TYR |
0.744 | 0.109 | -1 | 0.880 |
MAP2K4_TYR |
0.744 | 0.057 | -1 | 0.880 |
SBK |
0.743 | 0.010 | -3 | 0.586 |
BIKE |
0.742 | -0.062 | 1 | 0.195 |
TESK1_TYR |
0.741 | -0.016 | 3 | 0.875 |
CRIK |
0.741 | 0.018 | -3 | 0.715 |
ASK1 |
0.739 | -0.106 | 1 | 0.232 |
PINK1_TYR |
0.739 | -0.049 | 1 | 0.278 |
MYO3B |
0.738 | -0.060 | 2 | 0.804 |
NEK3 |
0.738 | -0.170 | 1 | 0.178 |
MAP2K7_TYR |
0.738 | -0.103 | 2 | 0.846 |
ALPHAK3 |
0.737 | -0.059 | -1 | 0.750 |
MYO3A |
0.737 | -0.064 | 1 | 0.237 |
PKMYT1_TYR |
0.736 | -0.064 | 3 | 0.837 |
TAO1 |
0.733 | -0.105 | 1 | 0.206 |
EPHA6 |
0.733 | 0.033 | -1 | 0.839 |
EPHB4 |
0.732 | 0.037 | -1 | 0.832 |
AAK1 |
0.731 | -0.045 | 1 | 0.149 |
LIMK2_TYR |
0.730 | -0.092 | -3 | 0.873 |
FGR |
0.730 | 0.019 | 1 | 0.303 |
SRMS |
0.729 | 0.116 | 1 | 0.361 |
YES1 |
0.729 | 0.009 | -1 | 0.846 |
RET |
0.729 | -0.162 | 1 | 0.224 |
INSRR |
0.729 | 0.053 | 3 | 0.717 |
STLK3 |
0.729 | -0.114 | 1 | 0.248 |
FER |
0.728 | 0.024 | 1 | 0.316 |
ITK |
0.727 | 0.104 | -1 | 0.784 |
EPHA4 |
0.726 | 0.037 | 2 | 0.748 |
CK1G3 |
0.725 | 0.010 | -3 | 0.399 |
EPHB1 |
0.725 | 0.060 | 1 | 0.339 |
MST1R |
0.725 | -0.157 | 3 | 0.785 |
LIMK1_TYR |
0.725 | -0.141 | 2 | 0.837 |
CSF1R |
0.724 | -0.094 | 3 | 0.754 |
TYRO3 |
0.724 | -0.066 | 3 | 0.763 |
ABL2 |
0.724 | -0.044 | -1 | 0.800 |
TYK2 |
0.724 | -0.235 | 1 | 0.204 |
JAK3 |
0.723 | -0.104 | 1 | 0.238 |
ROS1 |
0.723 | -0.094 | 3 | 0.736 |
PTK2 |
0.723 | 0.191 | -1 | 0.747 |
EPHB2 |
0.722 | 0.036 | -1 | 0.814 |
BMX |
0.722 | 0.082 | -1 | 0.697 |
DDR1 |
0.722 | -0.124 | 4 | 0.849 |
PTK2B |
0.722 | 0.174 | -1 | 0.787 |
NEK10_TYR |
0.722 | -0.139 | 1 | 0.175 |
SYK |
0.721 | 0.134 | -1 | 0.728 |
TEC |
0.721 | 0.066 | -1 | 0.734 |
MERTK |
0.721 | 0.051 | 3 | 0.742 |
PDGFRB |
0.721 | -0.093 | 3 | 0.770 |
FYN |
0.720 | 0.050 | -1 | 0.780 |
KIT |
0.720 | -0.072 | 3 | 0.758 |
ABL1 |
0.720 | -0.066 | -1 | 0.799 |
JAK2 |
0.720 | -0.221 | 1 | 0.201 |
BLK |
0.719 | -0.018 | -1 | 0.818 |
FGFR2 |
0.719 | -0.112 | 3 | 0.774 |
EGFR |
0.719 | -0.020 | 1 | 0.256 |
HCK |
0.719 | -0.053 | -1 | 0.809 |
EPHB3 |
0.719 | -0.019 | -1 | 0.817 |
LCK |
0.719 | -0.033 | -1 | 0.806 |
FLT1 |
0.717 | -0.046 | -1 | 0.802 |
MET |
0.717 | -0.036 | 3 | 0.750 |
FLT3 |
0.717 | -0.133 | 3 | 0.758 |
WEE1_TYR |
0.716 | -0.040 | -1 | 0.741 |
KDR |
0.715 | -0.100 | 3 | 0.719 |
EPHA7 |
0.715 | 0.017 | 2 | 0.749 |
JAK1 |
0.715 | -0.130 | 1 | 0.195 |
ERBB2 |
0.714 | -0.073 | 1 | 0.271 |
NTRK1 |
0.714 | -0.039 | -1 | 0.809 |
AXL |
0.714 | -0.057 | 3 | 0.742 |
TNK2 |
0.714 | -0.103 | 3 | 0.725 |
YANK2 |
0.712 | -0.030 | 2 | 0.398 |
EPHA5 |
0.712 | 0.022 | 2 | 0.737 |
FRK |
0.711 | -0.050 | -1 | 0.820 |
TNNI3K_TYR |
0.711 | -0.136 | 1 | 0.192 |
FGFR1 |
0.711 | -0.167 | 3 | 0.734 |
INSR |
0.710 | -0.045 | 3 | 0.696 |
FGFR3 |
0.710 | -0.092 | 3 | 0.743 |
NTRK3 |
0.710 | -0.025 | -1 | 0.759 |
EPHA3 |
0.710 | -0.028 | 2 | 0.731 |
BTK |
0.710 | -0.083 | -1 | 0.755 |
EPHA8 |
0.709 | 0.011 | -1 | 0.783 |
SRC |
0.709 | 0.001 | -1 | 0.794 |
MATK |
0.709 | -0.035 | -1 | 0.735 |
ALK |
0.709 | -0.067 | 3 | 0.678 |
TNK1 |
0.708 | -0.154 | 3 | 0.745 |
LTK |
0.708 | -0.092 | 3 | 0.704 |
PTK6 |
0.708 | -0.131 | -1 | 0.720 |
DDR2 |
0.707 | -0.063 | 3 | 0.703 |
NTRK2 |
0.707 | -0.094 | 3 | 0.717 |
PDGFRA |
0.707 | -0.204 | 3 | 0.760 |
TEK |
0.706 | -0.148 | 3 | 0.695 |
FLT4 |
0.705 | -0.132 | 3 | 0.718 |
CK1G2 |
0.705 | 0.023 | -3 | 0.496 |
ERBB4 |
0.705 | 0.017 | 1 | 0.311 |
EPHA1 |
0.705 | -0.083 | 3 | 0.730 |
FGFR4 |
0.704 | -0.069 | -1 | 0.758 |
CSK |
0.702 | -0.076 | 2 | 0.758 |
LYN |
0.701 | -0.076 | 3 | 0.675 |
EPHA2 |
0.701 | 0.015 | -1 | 0.741 |
IGF1R |
0.699 | -0.012 | 3 | 0.632 |
MUSK |
0.698 | -0.091 | 1 | 0.239 |
ZAP70 |
0.694 | 0.001 | -1 | 0.655 |
FES |
0.691 | 0.068 | -1 | 0.688 |