Motif 648 (n=250)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S2321 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6NMY6 | ANXA2P2 | S164 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00180 | KCNK1 | S303 | ochoa | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1) | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086, PubMed:8605869, PubMed:8978667). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}. |
| O00232 | PSMD12 | S335 | ochoa | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O00418 | EEF2K | S477 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O00515 | LAD1 | S272 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14490 | DLGAP1 | S362 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14523 | C2CD2L | S492 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14617 | AP3D1 | S1071 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O14641 | DVL2 | S158 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14976 | GAK | S829 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S436 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15061 | SYNM | S1080 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15164 | TRIM24 | S1028 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15403 | SLC16A6 | S237 | ochoa | Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) | Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. {ECO:0000250|UniProtKB:Q7TMR7}. |
| O15432 | SLC31A2 | S77 | ochoa | Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) | Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}. |
| O15439 | ABCC4 | S664 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43166 | SIPA1L1 | S1181 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43293 | DAPK3 | S312 | ochoa | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| O43491 | EPB41L2 | S884 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43493 | TGOLN2 | S352 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43566 | RGS14 | S291 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60271 | SPAG9 | S332 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60503 | ADCY9 | S691 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60716 | CTNND1 | Y291 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75052 | NOS1AP | S195 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75152 | ZC3H11A | S119 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75363 | BCAS1 | S234 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75410 | TACC1 | S55 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75410 | TACC1 | S494 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75665 | OFD1 | S723 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75665 | OFD1 | S954 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75886 | STAM2 | S375 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| O75995 | SASH3 | S113 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O76070 | SNCG | S54 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O94763 | URI1 | S452 | ochoa | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| O94885 | SASH1 | S104 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94972 | TRIM37 | S803 | ochoa | E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}. |
| O95163 | ELP1 | S1170 | ochoa | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}. |
| O95239 | KIF4A | S1139 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95400 | CD2BP2 | S61 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| O95551 | TDP2 | S98 | ochoa | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| P07355 | ANXA2 | S164 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08172 | CHRM2 | S286 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08238 | HSP90AB1 | S535 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10809 | HSPD1 | S256 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11388 | TOP2A | S1354 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P13639 | EEF2 | S623 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P16144 | ITGB4 | S1212 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16150 | SPN | S368 | ochoa | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P16220 | CREB1 | S103 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
| P16284 | PECAM1 | S700 | ochoa|psp | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16591 | FER | S411 | ochoa | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}. |
| P17661 | DES | S301 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17661 | DES | S361 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18669 | PGAM1 | S155 | ochoa | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P20265 | POU3F2 | S341 | ochoa | POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) | Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}. |
| P23193 | TCEA1 | S110 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P23508 | MCC | S684 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P23588 | EIF4B | S462 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P25054 | APC | S963 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28715 | ERCC5 | S310 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29590 | PML | S582 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P32926 | DSG3 | S877 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P33991 | MCM4 | S145 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35367 | HRH1 | S233 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P38398 | BRCA1 | S426 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42166 | TMPO | S351 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42704 | LRPPRC | S1025 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P46100 | ATRX | S748 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S1915 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S894 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49023 | PXN | S219 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49321 | NASP | S662 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P50579 | METAP2 | S63 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P50851 | LRBA | S1064 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P52566 | ARHGDIB | S20 | ochoa|psp | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P52948 | NUP98 | Y659 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P61769 | B2M | S75 | ochoa | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| P62258 | YWHAE | S213 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S210 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63151 | PPP2R2A | S279 | ochoa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q00536 | CDK16 | S89 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00987 | MDM2 | S256 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02880 | TOP2B | S1476 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02952 | AKAP12 | S915 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S308 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03188 | CENPC | S713 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04721 | NOTCH2 | S1855 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q08378 | GOLGA3 | S21 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08AE8 | SPIRE1 | S478 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q09666 | AHNAK | S298 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S333 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12959 | DLG1 | S570 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13017 | ARHGAP5 | T1141 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13422 | IKZF1 | S364 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13813 | SPTAN1 | S1479 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14103 | HNRNPD | S83 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q14153 | FAM53B | S248 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14498 | RBM39 | S336 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q15398 | DLGAP5 | S777 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15527 | SURF2 | S166 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q15772 | SPEG | S516 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16643 | DBN1 | Y597 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q1KMD3 | HNRNPUL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2M1P5 | KIF7 | S458 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q2NKX8 | ERCC6L | Y867 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2NKX8 | ERCC6L | S1041 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3SXY8 | ARL13B | S341 | ochoa | ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (PubMed:38219074). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (PubMed:23223633). {ECO:0000269|PubMed:23150559, ECO:0000269|PubMed:23223633, ECO:0000269|PubMed:38219074}. |
| Q58FF7 | HSP90AB3P | S408 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5C9Z4 | NOM1 | S320 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5JTV8 | TOR1AIP1 | S230 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5JWF2 | GNAS | S995 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5TH69 | ARFGEF3 | S1851 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5UIP0 | RIF1 | S1151 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZL5 | ZMYM4 | S1091 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q63HQ0 | AP1AR | S174 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q641Q2 | WASHC2A | S700 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68DQ2 | CRYBG3 | S2104 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6GQQ9 | OTUD7B | S478 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6IAA8 | LAMTOR1 | S45 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6KC79 | NIPBL | S591 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P158 | DHX57 | S77 | ochoa | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
| Q6UXK2 | ISLR2 | S720 | ochoa | Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein) | Required for axon extension during neural development. {ECO:0000250}. |
| Q6VMQ6 | ATF7IP | S477 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6Y7W6 | GIGYF2 | S377 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q70EL4 | USP43 | S1068 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q71F23 | CENPU | S111 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z4V5 | HDGFL2 | S149 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z4V5 | HDGFL2 | S369 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z569 | BRAP | S97 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q7Z5K2 | WAPL | S257 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z5L9 | IRF2BP2 | S293 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6I6 | ARHGAP30 | S865 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6Z7 | HUWE1 | S2365 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TI0 | TBC1D1 | S559 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86U86 | PBRM1 | S378 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UE4 | MTDH | S362 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UR5 | RIMS1 | S1496 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q8IVJ1 | SLC41A1 | S76 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
| Q8IWS0 | PHF6 | S158 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IX03 | WWC1 | S144 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IXW5 | RPAP2 | S483 | ochoa | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}. |
| Q8N1G2 | CMTR1 | S66 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N4S9 | MARVELD2 | S390 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8N5A5 | ZGPAT | S56 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N5C8 | TAB3 | S672 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NCE2 | MTMR14 | S517 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NE00 | TMEM104 | S94 | ochoa | Transmembrane protein 104 | None |
| Q8TD26 | CHD6 | S2058 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8WUA4 | GTF3C2 | S775 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUM0 | NUP133 | S492 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVM7 | STAG1 | S1065 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WWI1 | LMO7 | S879 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXH0 | SYNE2 | S4126 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WZ73 | RFFL | S229 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92560 | BAP1 | S292 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92576 | PHF3 | S345 | ochoa | PHD finger protein 3 | None |
| Q92844 | TANK | S129 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q96A32 | MYL11 | S20 | ochoa | Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) | Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}. |
| Q96C24 | SYTL4 | S204 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96EB6 | SIRT1 | S172 | psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96GU1 | PAGE5 | S31 | ochoa | P antigen family member 5 (PAGE-5) (Cancer/testis antigen 16.1) (CT16.1) (G antigen family E member 1) (Prostate-associated gene 5 protein) | None |
| Q96JM2 | ZNF462 | S2144 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96K76 | USP47 | S148 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96L91 | EP400 | S934 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96RG2 | PASK | S582 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RG2 | PASK | S1280 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RL1 | UIMC1 | S200 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99567 | NUP88 | S170 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99590 | SCAF11 | S338 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99618 | CDCA3 | S168 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q9BRX2 | PELO | S58 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BUR4 | WRAP53 | S90 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BV73 | CEP250 | S2424 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BVJ6 | UTP14A | S81 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BVS4 | RIOK2 | S335 | ochoa|psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BZ95 | NSD3 | S571 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9H2H9 | SLC38A1 | S28 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2Y7 | ZNF106 | S661 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4A3 | WNK1 | S2005 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4G0 | EPB41L1 | T78 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4L5 | OSBPL3 | S374 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H5J8 | TAF1D | S26 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6U6 | BCAS3 | S896 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H814 | PHAX | T353 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9HBD1 | RC3H2 | S837 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NPI1 | BRD7 | S41 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NQC3 | RTN4 | S863 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NR09 | BIRC6 | S486 | ochoa|psp | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NUQ6 | SPATS2L | S120 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NWH9 | SLTM | S553 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYF8 | BCLAF1 | S209 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYP3 | DONSON | S139 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NZT2 | OGFR | S423 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P246 | STIM2 | S346 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P266 | JCAD | S629 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D1 | CHD7 | S2254 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2D6 | FAM135A | S639 | ochoa | Protein FAM135A | None |
| Q9UBU9 | NXF1 | S62 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UHB6 | LIMA1 | S266 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S706 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHX1 | PUF60 | S446 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UJD0 | RIMS3 | S114 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
| Q9UKL3 | CASP8AP2 | S945 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKV8 | AGO2 | S834 | psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9UL54 | TAOK2 | S414 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULH0 | KIDINS220 | S1486 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULH0 | KIDINS220 | S1531 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULW0 | TPX2 | S542 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UNF0 | PACSIN2 | S375 | ochoa|psp | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UNF1 | MAGED2 | S194 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UPN4 | CEP131 | S450 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPP1 | PHF8 | S857 | ochoa|psp | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPV0 | CEP164 | S273 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPV0 | CEP164 | S455 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ26 | RIMS2 | S1215 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQC2 | GAB2 | S425 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y243 | AKT3 | S123 | ochoa | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}. |
| Q9Y2J2 | EPB41L3 | S91 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2L5 | TRAPPC8 | S269 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y2W1 | THRAP3 | S187 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y450 | HBS1L | S67 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y4J8 | DTNA | S665 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y5P4 | CERT1 | S126 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y6D6 | ARFGEF1 | S410 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6E2 | BZW2 | S205 | ochoa | eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) | Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| Q9Y6R1 | SLC4A4 | Y64 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6R1 | SLC4A4 | S79 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6X4 | FAM169A | S361 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| R4GMW8 | BIVM-ERCC5 | S764 | ochoa | DNA excision repair protein ERCC-5 | None |
| O00444 | PLK4 | S411 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P11586 | MTHFD1 | S129 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| Q01105 | SET | S168 | Sugiyama | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q58FF8 | HSP90AB2P | S308 | Sugiyama | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q8WVC0 | LEO1 | S75 | Sugiyama | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| O15111 | CHUK | S126 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O60566 | BUB1B | S686 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9BRS2 | RIOK1 | S507 | Sugiyama | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}. |
| P23443 | RPS6KB1 | S78 | Sugiyama | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P41235 | HNF4A | S265 | PSP | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| Q9H1I8 | ASCC2 | S552 | Sugiyama | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| P49336 | CDK8 | Y247 | Sugiyama | Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:30905399}. |
| O14640 | DVL1 | S142 | SIGNOR | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Q13526 | PIN1 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q9NYF8 | BCLAF1 | Y322 | Sugiyama | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| P30622 | CLIP1 | S1328 | Sugiyama | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| Q8TD08 | MAPK15 | S353 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q08378 | GOLGA3 | S500 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 1.418594e-10 | 9.848 |
| R-HSA-68886 | M Phase | 1.310482e-08 | 7.883 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.359218e-08 | 7.867 |
| R-HSA-68877 | Mitotic Prometaphase | 5.760383e-06 | 5.240 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 6.987288e-05 | 4.156 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 8.017872e-05 | 4.096 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.227868e-04 | 3.911 |
| R-HSA-68875 | Mitotic Prophase | 1.367739e-04 | 3.864 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.701974e-04 | 3.769 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.908903e-04 | 3.719 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.513982e-04 | 3.600 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.461554e-04 | 3.461 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.960663e-04 | 3.402 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.496616e-04 | 3.347 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.496616e-04 | 3.347 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 5.085458e-04 | 3.294 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 5.085458e-04 | 3.294 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 6.434993e-04 | 3.191 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.888329e-04 | 3.230 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.546228e-04 | 3.184 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.863635e-04 | 3.163 |
| R-HSA-157118 | Signaling by NOTCH | 6.953038e-04 | 3.158 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 7.467289e-04 | 3.127 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 7.202453e-04 | 3.143 |
| R-HSA-180746 | Nuclear import of Rev protein | 8.036330e-04 | 3.095 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.904119e-04 | 3.102 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.940161e-04 | 3.049 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.080851e-03 | 2.966 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.383184e-03 | 2.859 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.383184e-03 | 2.859 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.097212e-03 | 2.960 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.429198e-03 | 2.845 |
| R-HSA-68882 | Mitotic Anaphase | 9.599871e-04 | 3.018 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.948909e-04 | 3.002 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.302069e-03 | 2.885 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.204636e-03 | 2.919 |
| R-HSA-191859 | snRNP Assembly | 1.204636e-03 | 2.919 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.033313e-03 | 2.986 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.463618e-03 | 2.835 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.463618e-03 | 2.835 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.210759e-03 | 2.917 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.453689e-03 | 2.838 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.332769e-03 | 2.875 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.524980e-03 | 2.817 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.611729e-03 | 2.793 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.611729e-03 | 2.793 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.603689e-03 | 2.795 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.731425e-03 | 2.762 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.088860e-03 | 2.680 |
| R-HSA-1299308 | Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | 2.269897e-03 | 2.644 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.365427e-03 | 2.626 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.455892e-03 | 2.610 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.659436e-03 | 2.575 |
| R-HSA-3371556 | Cellular response to heat stress | 2.663347e-03 | 2.575 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.834682e-03 | 2.547 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.903371e-03 | 2.537 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.730677e-03 | 2.564 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.084109e-03 | 2.511 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.506670e-03 | 2.455 |
| R-HSA-380287 | Centrosome maturation | 3.470629e-03 | 2.460 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.466815e-03 | 2.460 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 3.506670e-03 | 2.455 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.102776e-03 | 2.508 |
| R-HSA-69275 | G2/M Transition | 3.340617e-03 | 2.476 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.573867e-03 | 2.447 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.470629e-03 | 2.460 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.817181e-03 | 2.418 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.185306e-03 | 2.378 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.193814e-03 | 2.377 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 4.570453e-03 | 2.340 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 4.570453e-03 | 2.340 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.955091e-03 | 2.305 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.076438e-03 | 2.294 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.493574e-03 | 2.260 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.669051e-03 | 2.246 |
| R-HSA-162582 | Signal Transduction | 6.139496e-03 | 2.212 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.789847e-03 | 2.168 |
| R-HSA-447038 | NrCAM interactions | 6.719067e-03 | 2.173 |
| R-HSA-186712 | Regulation of beta-cell development | 6.536048e-03 | 2.185 |
| R-HSA-2028269 | Signaling by Hippo | 6.832243e-03 | 2.165 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 6.943148e-03 | 2.158 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.258487e-03 | 2.139 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.976547e-03 | 2.098 |
| R-HSA-164378 | PKA activation in glucagon signalling | 7.709401e-03 | 2.113 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.366231e-03 | 2.133 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.807707e-03 | 2.107 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 8.738119e-03 | 2.059 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.072536e-02 | 1.970 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.081392e-02 | 1.966 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.085885e-02 | 1.964 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.117536e-02 | 1.952 |
| R-HSA-165159 | MTOR signalling | 1.156792e-02 | 1.937 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.325569e-02 | 1.878 |
| R-HSA-69481 | G2/M Checkpoints | 1.247654e-02 | 1.904 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 1.325569e-02 | 1.878 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.327301e-02 | 1.877 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.339233e-02 | 1.873 |
| R-HSA-70171 | Glycolysis | 1.339233e-02 | 1.873 |
| R-HSA-109581 | Apoptosis | 1.385932e-02 | 1.858 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 1.403647e-02 | 1.853 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.461233e-02 | 1.835 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.492782e-02 | 1.826 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.585982e-02 | 1.800 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.711622e-02 | 1.767 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.866349e-02 | 1.729 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.866349e-02 | 1.729 |
| R-HSA-211000 | Gene Silencing by RNA | 1.818267e-02 | 1.740 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.009392e-02 | 1.697 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.009392e-02 | 1.697 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.165917e-02 | 1.664 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 2.165917e-02 | 1.664 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 2.165917e-02 | 1.664 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.483950e-02 | 1.605 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 2.483950e-02 | 1.605 |
| R-HSA-8953854 | Metabolism of RNA | 2.495076e-02 | 1.603 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.513230e-02 | 1.600 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.694886e-02 | 1.569 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.582344e-02 | 1.588 |
| R-HSA-70326 | Glucose metabolism | 2.738244e-02 | 1.563 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.883378e-02 | 1.540 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.820047e-02 | 1.550 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.982141e-02 | 1.525 |
| R-HSA-5617833 | Cilium Assembly | 3.019292e-02 | 1.520 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.078685e-02 | 1.512 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.078685e-02 | 1.512 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.119630e-02 | 1.506 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 3.172572e-02 | 1.499 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.280780e-02 | 1.484 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.394052e-02 | 1.469 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.394052e-02 | 1.469 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.394052e-02 | 1.469 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.394052e-02 | 1.469 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.394052e-02 | 1.469 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.394052e-02 | 1.469 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.394052e-02 | 1.469 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.927444e-02 | 1.406 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.661769e-02 | 1.436 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.705200e-02 | 1.431 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.926719e-02 | 1.406 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.541787e-02 | 1.451 |
| R-HSA-4641258 | Degradation of DVL | 4.156318e-02 | 1.381 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.218275e-02 | 1.375 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 4.326726e-02 | 1.364 |
| R-HSA-5357801 | Programmed Cell Death | 4.335585e-02 | 1.363 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.390300e-02 | 1.358 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.566218e-02 | 1.340 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.633740e-02 | 1.334 |
| R-HSA-112316 | Neuronal System | 4.648674e-02 | 1.333 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 4.741183e-02 | 1.324 |
| R-HSA-9664420 | Killing mechanisms | 4.741183e-02 | 1.324 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 4.741183e-02 | 1.324 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.888463e-02 | 1.311 |
| R-HSA-913531 | Interferon Signaling | 4.994695e-02 | 1.301 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.047785e-02 | 1.297 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 5.047785e-02 | 1.297 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.047785e-02 | 1.297 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 5.047785e-02 | 1.297 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 6.065259e-02 | 1.217 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 6.065259e-02 | 1.217 |
| R-HSA-6807070 | PTEN Regulation | 5.528712e-02 | 1.257 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.174756e-02 | 1.286 |
| R-HSA-5688426 | Deubiquitination | 5.130286e-02 | 1.290 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.393051e-02 | 1.268 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 6.065259e-02 | 1.217 |
| R-HSA-9831926 | Nephron development | 6.065259e-02 | 1.217 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 6.065259e-02 | 1.217 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.091868e-02 | 1.215 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.237794e-02 | 1.205 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.323404e-02 | 1.199 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.504663e-02 | 1.187 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 6.531600e-02 | 1.185 |
| R-HSA-9659379 | Sensory processing of sound | 6.537743e-02 | 1.185 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.550123e-02 | 1.184 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 9.841638e-02 | 1.007 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.290278e-01 | 0.889 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.439429e-01 | 0.842 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.439429e-01 | 0.842 |
| R-HSA-9645135 | STAT5 Activation | 1.439429e-01 | 0.842 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.586035e-01 | 0.800 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.730139e-01 | 0.762 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 1.730139e-01 | 0.762 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.730139e-01 | 0.762 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.730139e-01 | 0.762 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.730139e-01 | 0.762 |
| R-HSA-170984 | ARMS-mediated activation | 1.871784e-01 | 0.728 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.871784e-01 | 0.728 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 7.997948e-02 | 1.097 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 7.997948e-02 | 1.097 |
| R-HSA-210990 | PECAM1 interactions | 2.147862e-01 | 0.668 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.147862e-01 | 0.668 |
| R-HSA-4839744 | Signaling by APC mutants | 2.147862e-01 | 0.668 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.147862e-01 | 0.668 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.147862e-01 | 0.668 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.147862e-01 | 0.668 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 2.282377e-01 | 0.642 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.282377e-01 | 0.642 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.282377e-01 | 0.642 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.414595e-01 | 0.617 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.414595e-01 | 0.617 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.414595e-01 | 0.617 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.414595e-01 | 0.617 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.414595e-01 | 0.617 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.414595e-01 | 0.617 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.544557e-01 | 0.594 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.797861e-01 | 0.553 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.797861e-01 | 0.553 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.797861e-01 | 0.553 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 8.666573e-02 | 1.062 |
| R-HSA-1221632 | Meiotic synapsis | 8.997425e-02 | 1.046 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.042590e-01 | 0.517 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.329533e-01 | 0.633 |
| R-HSA-774815 | Nucleosome assembly | 2.329533e-01 | 0.633 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.774443e-01 | 0.557 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.838016e-01 | 0.547 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.154780e-01 | 0.501 |
| R-HSA-1980145 | Signaling by NOTCH2 | 1.583970e-01 | 0.800 |
| R-HSA-6798695 | Neutrophil degranulation | 3.136526e-01 | 0.504 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.011011e-01 | 0.697 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.147862e-01 | 0.668 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.921279e-01 | 0.534 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.766512e-01 | 0.753 |
| R-HSA-199920 | CREB phosphorylation | 1.439429e-01 | 0.842 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 2.282377e-01 | 0.642 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.282377e-01 | 0.642 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.042590e-01 | 0.517 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.000381e-01 | 0.699 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.037201e-01 | 0.984 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 1.138538e-01 | 0.944 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.672300e-01 | 0.573 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.042590e-01 | 0.517 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.014539e-01 | 0.696 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.329533e-01 | 0.633 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 8.997425e-02 | 1.046 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.964991e-01 | 0.528 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.290278e-01 | 0.889 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.063622e-01 | 0.973 |
| R-HSA-9766229 | Degradation of CDH1 | 7.706284e-02 | 1.113 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.456438e-01 | 0.610 |
| R-HSA-4086400 | PCP/CE pathway | 1.869748e-01 | 0.728 |
| R-HSA-3371511 | HSF1 activation | 1.705284e-01 | 0.768 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.014539e-01 | 0.696 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.329533e-01 | 0.633 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.838016e-01 | 0.547 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.921279e-01 | 0.534 |
| R-HSA-69541 | Stabilization of p53 | 1.889961e-01 | 0.724 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.028359e-01 | 0.519 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.718123e-01 | 0.765 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 6.673308e-02 | 1.176 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 9.841638e-02 | 1.007 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.290278e-01 | 0.889 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.730139e-01 | 0.762 |
| R-HSA-176974 | Unwinding of DNA | 1.871784e-01 | 0.728 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.011011e-01 | 0.697 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 9.026503e-02 | 1.044 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.282377e-01 | 0.642 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.282377e-01 | 0.642 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.544557e-01 | 0.594 |
| R-HSA-9634597 | GPER1 signaling | 7.397258e-02 | 1.131 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.797861e-01 | 0.553 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.797861e-01 | 0.553 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.279031e-01 | 0.484 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.140030e-01 | 0.670 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.774443e-01 | 0.557 |
| R-HSA-9609690 | HCMV Early Events | 8.148050e-02 | 1.089 |
| R-HSA-1500620 | Meiosis | 2.177771e-01 | 0.662 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.217804e-01 | 0.492 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.414595e-01 | 0.617 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.403800e-01 | 0.619 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.871784e-01 | 0.728 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.279031e-01 | 0.484 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.464394e-01 | 0.834 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 7.498467e-02 | 1.125 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 7.997948e-02 | 1.097 |
| R-HSA-9620244 | Long-term potentiation | 1.009134e-01 | 0.996 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.231555e-01 | 0.910 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.618826e-01 | 0.791 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.810024e-02 | 1.107 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.618826e-01 | 0.791 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.458269e-01 | 0.836 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 1.138538e-01 | 0.944 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.871784e-01 | 0.728 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.672300e-01 | 0.573 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.464394e-01 | 0.834 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.077184e-01 | 0.683 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.710836e-01 | 0.567 |
| R-HSA-73886 | Chromosome Maintenance | 2.063264e-01 | 0.685 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.464394e-01 | 0.834 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 7.997948e-02 | 1.097 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.394531e-01 | 0.856 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 9.656969e-02 | 1.015 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.871784e-01 | 0.728 |
| R-HSA-73942 | DNA Damage Reversal | 2.797861e-01 | 0.553 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.997425e-02 | 1.046 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.755838e-02 | 1.170 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.063622e-01 | 0.973 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.583593e-01 | 0.588 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.583593e-01 | 0.588 |
| R-HSA-195721 | Signaling by WNT | 3.115711e-01 | 0.506 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.464394e-01 | 0.834 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.766512e-01 | 0.753 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.699297e-01 | 0.770 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.802543e-01 | 0.552 |
| R-HSA-205025 | NADE modulates death signalling | 9.841638e-02 | 1.007 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.730139e-01 | 0.762 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.730139e-01 | 0.762 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 1.174874e-01 | 0.930 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.797861e-01 | 0.553 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.797861e-01 | 0.553 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.952123e-01 | 0.709 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.952123e-01 | 0.709 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.014539e-01 | 0.696 |
| R-HSA-169893 | Prolonged ERK activation events | 2.921279e-01 | 0.534 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.726497e-01 | 0.564 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.225750e-01 | 0.491 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.077184e-01 | 0.683 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.889961e-01 | 0.724 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.729797e-01 | 0.762 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.099657e-01 | 0.509 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.755838e-02 | 1.170 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.819194e-01 | 0.550 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.052811e-01 | 0.515 |
| R-HSA-390650 | Histamine receptors | 8.271102e-02 | 1.082 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.871784e-01 | 0.728 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 3.042590e-01 | 0.517 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.912486e-01 | 0.536 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.912486e-01 | 0.536 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.912486e-01 | 0.536 |
| R-HSA-114608 | Platelet degranulation | 2.315851e-01 | 0.635 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.161828e-01 | 0.500 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.014539e-01 | 0.696 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.657417e-01 | 0.781 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.395885e-01 | 0.855 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.280683e-01 | 0.484 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.145490e-01 | 0.668 |
| R-HSA-9609646 | HCMV Infection | 1.886129e-01 | 0.724 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.436956e-01 | 0.613 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.586035e-01 | 0.800 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 2.011011e-01 | 0.697 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.011011e-01 | 0.697 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 7.997948e-02 | 1.097 |
| R-HSA-425381 | Bicarbonate transporters | 2.147862e-01 | 0.668 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.414595e-01 | 0.617 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.414595e-01 | 0.617 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.672300e-01 | 0.573 |
| R-HSA-163615 | PKA activation | 3.279031e-01 | 0.484 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.101278e-01 | 0.958 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.146677e-01 | 0.502 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.047917e-02 | 1.094 |
| R-HSA-69242 | S Phase | 1.617698e-01 | 0.791 |
| R-HSA-446728 | Cell junction organization | 2.580463e-01 | 0.588 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.414595e-01 | 0.617 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.583970e-01 | 0.800 |
| R-HSA-450294 | MAP kinase activation | 1.182364e-01 | 0.927 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.766512e-01 | 0.753 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.575548e-01 | 0.589 |
| R-HSA-73894 | DNA Repair | 1.252810e-01 | 0.902 |
| R-HSA-1500931 | Cell-Cell communication | 2.273708e-01 | 0.643 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.659069e-01 | 0.575 |
| R-HSA-9658195 | Leishmania infection | 2.659069e-01 | 0.575 |
| R-HSA-9607240 | FLT3 Signaling | 2.014539e-01 | 0.696 |
| R-HSA-202424 | Downstream TCR signaling | 2.449484e-01 | 0.611 |
| R-HSA-397014 | Muscle contraction | 2.145490e-01 | 0.668 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.312882e-01 | 0.636 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.290278e-01 | 0.889 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.290278e-01 | 0.889 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.871784e-01 | 0.728 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.871784e-01 | 0.728 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.147862e-01 | 0.668 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.147862e-01 | 0.668 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.921279e-01 | 0.534 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.182364e-01 | 0.927 |
| R-HSA-448424 | Interleukin-17 signaling | 1.533706e-01 | 0.814 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.699297e-01 | 0.770 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 8.385737e-02 | 1.076 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.222627e-01 | 0.653 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.393298e-01 | 0.621 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.393298e-01 | 0.621 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.161828e-01 | 0.500 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.279031e-01 | 0.484 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.495306e-01 | 0.603 |
| R-HSA-74160 | Gene expression (Transcription) | 1.733650e-01 | 0.761 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.277815e-02 | 1.138 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.767334e-01 | 0.558 |
| R-HSA-111933 | Calmodulin induced events | 1.705284e-01 | 0.768 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.295894e-01 | 0.887 |
| R-HSA-4839726 | Chromatin organization | 1.862873e-01 | 0.730 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.290278e-01 | 0.889 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.730139e-01 | 0.762 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 7.009513e-02 | 1.154 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.063622e-01 | 0.973 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2.544557e-01 | 0.594 |
| R-HSA-111997 | CaM pathway | 1.705284e-01 | 0.768 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.161828e-01 | 0.500 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.279031e-01 | 0.484 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.373534e-01 | 0.862 |
| R-HSA-162906 | HIV Infection | 6.692788e-02 | 1.174 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.011011e-01 | 0.697 |
| R-HSA-418597 | G alpha (z) signalling events | 9.674681e-02 | 1.014 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.838016e-01 | 0.547 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.009134e-01 | 0.996 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.009134e-01 | 0.996 |
| R-HSA-111996 | Ca-dependent events | 2.140030e-01 | 0.670 |
| R-HSA-162587 | HIV Life Cycle | 8.496118e-02 | 1.071 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 2.147862e-01 | 0.668 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.118883e-01 | 0.951 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.329533e-01 | 0.633 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.815787e-01 | 0.741 |
| R-HSA-177929 | Signaling by EGFR | 3.028359e-01 | 0.519 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.687911e-02 | 1.175 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.096287e-01 | 0.960 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.140030e-01 | 0.670 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.203053e-01 | 0.657 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.871784e-01 | 0.728 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.414595e-01 | 0.617 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.544557e-01 | 0.594 |
| R-HSA-420092 | Glucagon-type ligand receptors | 1.231555e-01 | 0.910 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.797861e-01 | 0.553 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.378805e-02 | 1.077 |
| R-HSA-75893 | TNF signaling | 1.002089e-01 | 0.999 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.414595e-01 | 0.617 |
| R-HSA-8876725 | Protein methylation | 2.797861e-01 | 0.553 |
| R-HSA-375280 | Amine ligand-binding receptors | 2.266229e-01 | 0.645 |
| R-HSA-9610379 | HCMV Late Events | 1.873984e-01 | 0.727 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.730139e-01 | 0.762 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.730139e-01 | 0.762 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.871784e-01 | 0.728 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.544557e-01 | 0.594 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.797861e-01 | 0.553 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.521722e-01 | 0.818 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.392943e-01 | 0.621 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.521722e-01 | 0.818 |
| R-HSA-373760 | L1CAM interactions | 1.888137e-01 | 0.724 |
| R-HSA-73887 | Death Receptor Signaling | 1.786947e-01 | 0.748 |
| R-HSA-180292 | GAB1 signalosome | 3.279031e-01 | 0.484 |
| R-HSA-1266738 | Developmental Biology | 3.155047e-01 | 0.501 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 8.666573e-02 | 1.062 |
| R-HSA-877300 | Interferon gamma signaling | 1.932851e-01 | 0.714 |
| R-HSA-168255 | Influenza Infection | 2.585385e-01 | 0.587 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.279031e-01 | 0.484 |
| R-HSA-1538133 | G0 and Early G1 | 1.405342e-01 | 0.852 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.959217e-01 | 0.529 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.583970e-01 | 0.800 |
| R-HSA-75153 | Apoptotic execution phase | 6.796360e-02 | 1.168 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 2.147862e-01 | 0.668 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.002089e-01 | 0.999 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.266229e-01 | 0.645 |
| R-HSA-9679506 | SARS-CoV Infections | 2.946641e-01 | 0.531 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.816725e-01 | 0.741 |
| R-HSA-5619102 | SLC transporter disorders | 1.035166e-01 | 0.985 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.774443e-01 | 0.557 |
| R-HSA-72306 | tRNA processing | 2.298785e-01 | 0.639 |
| R-HSA-418346 | Platelet homeostasis | 3.334099e-01 | 0.477 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.342129e-01 | 0.476 |
| R-HSA-112043 | PLC beta mediated events | 3.343405e-01 | 0.476 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.394231e-01 | 0.469 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.394231e-01 | 0.469 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.394231e-01 | 0.469 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.394231e-01 | 0.469 |
| R-HSA-392517 | Rap1 signalling | 3.394231e-01 | 0.469 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.394231e-01 | 0.469 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.394231e-01 | 0.469 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.405956e-01 | 0.468 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.405956e-01 | 0.468 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.405956e-01 | 0.468 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.405956e-01 | 0.468 |
| R-HSA-9707616 | Heme signaling | 3.405956e-01 | 0.468 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.427840e-01 | 0.465 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.427840e-01 | 0.465 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.468325e-01 | 0.460 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.474677e-01 | 0.459 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.483245e-01 | 0.458 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.507465e-01 | 0.455 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.507465e-01 | 0.455 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.507465e-01 | 0.455 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.507465e-01 | 0.455 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.507465e-01 | 0.455 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.507465e-01 | 0.455 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.507465e-01 | 0.455 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.507465e-01 | 0.455 |
| R-HSA-373753 | Nephrin family interactions | 3.507465e-01 | 0.455 |
| R-HSA-202403 | TCR signaling | 3.521481e-01 | 0.453 |
| R-HSA-9612973 | Autophagy | 3.536472e-01 | 0.451 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.592466e-01 | 0.445 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.618764e-01 | 0.441 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.618764e-01 | 0.441 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.618764e-01 | 0.441 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.618764e-01 | 0.441 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.618764e-01 | 0.441 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.618764e-01 | 0.441 |
| R-HSA-210991 | Basigin interactions | 3.618764e-01 | 0.441 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.638045e-01 | 0.439 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.661642e-01 | 0.436 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.708257e-01 | 0.431 |
| R-HSA-199991 | Membrane Trafficking | 3.715496e-01 | 0.430 |
| R-HSA-112040 | G-protein mediated events | 3.715737e-01 | 0.430 |
| R-HSA-9830369 | Kidney development | 3.715737e-01 | 0.430 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.728161e-01 | 0.429 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.728161e-01 | 0.429 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.801294e-01 | 0.420 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.835690e-01 | 0.416 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.835690e-01 | 0.416 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.835690e-01 | 0.416 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.835690e-01 | 0.416 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.847705e-01 | 0.415 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.898830e-01 | 0.409 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.898830e-01 | 0.409 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.898830e-01 | 0.409 |
| R-HSA-418990 | Adherens junctions interactions | 3.925637e-01 | 0.406 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.940284e-01 | 0.404 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.941382e-01 | 0.404 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.941382e-01 | 0.404 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.941382e-01 | 0.404 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.941382e-01 | 0.404 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 3.941382e-01 | 0.404 |
| R-HSA-3000170 | Syndecan interactions | 3.941382e-01 | 0.404 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.959339e-01 | 0.402 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.959339e-01 | 0.402 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.959339e-01 | 0.402 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.959339e-01 | 0.402 |
| R-HSA-5693538 | Homology Directed Repair | 3.986440e-01 | 0.399 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.019572e-01 | 0.396 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.019572e-01 | 0.396 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.032501e-01 | 0.394 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.032501e-01 | 0.394 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.045268e-01 | 0.393 |
| R-HSA-429947 | Deadenylation of mRNA | 4.045268e-01 | 0.393 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.045268e-01 | 0.393 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 4.045268e-01 | 0.393 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.045268e-01 | 0.393 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 4.045268e-01 | 0.393 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.045268e-01 | 0.393 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.045268e-01 | 0.393 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.079522e-01 | 0.389 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.139180e-01 | 0.383 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.147379e-01 | 0.382 |
| R-HSA-9839394 | TGFBR3 expression | 4.147379e-01 | 0.382 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.147379e-01 | 0.382 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.147379e-01 | 0.382 |
| R-HSA-3214842 | HDMs demethylate histones | 4.147379e-01 | 0.382 |
| R-HSA-3000157 | Laminin interactions | 4.147379e-01 | 0.382 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.170063e-01 | 0.380 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.170063e-01 | 0.380 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.196489e-01 | 0.377 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.198538e-01 | 0.377 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.198538e-01 | 0.377 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.233137e-01 | 0.373 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.233137e-01 | 0.373 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.233137e-01 | 0.373 |
| R-HSA-525793 | Myogenesis | 4.247746e-01 | 0.372 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.247746e-01 | 0.372 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.247746e-01 | 0.372 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 4.247746e-01 | 0.372 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.247746e-01 | 0.372 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.247746e-01 | 0.372 |
| R-HSA-5689603 | UCH proteinases | 4.257590e-01 | 0.371 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.257590e-01 | 0.371 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.302877e-01 | 0.366 |
| R-HSA-2262752 | Cellular responses to stress | 4.316388e-01 | 0.365 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.346397e-01 | 0.362 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.346397e-01 | 0.362 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.346397e-01 | 0.362 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.346397e-01 | 0.362 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.346397e-01 | 0.362 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.346397e-01 | 0.362 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.346397e-01 | 0.362 |
| R-HSA-69206 | G1/S Transition | 4.351848e-01 | 0.361 |
| R-HSA-194138 | Signaling by VEGF | 4.351848e-01 | 0.361 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.443362e-01 | 0.352 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.443362e-01 | 0.352 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.443362e-01 | 0.352 |
| R-HSA-622312 | Inflammasomes | 4.443362e-01 | 0.352 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.490597e-01 | 0.348 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.538671e-01 | 0.343 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.538671e-01 | 0.343 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.538671e-01 | 0.343 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.538671e-01 | 0.343 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.538671e-01 | 0.343 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.538671e-01 | 0.343 |
| R-HSA-8939211 | ESR-mediated signaling | 4.565326e-01 | 0.341 |
| R-HSA-1474165 | Reproduction | 4.620460e-01 | 0.335 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.632350e-01 | 0.334 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.632350e-01 | 0.334 |
| R-HSA-2424491 | DAP12 signaling | 4.632350e-01 | 0.334 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.632350e-01 | 0.334 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.632350e-01 | 0.334 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.632350e-01 | 0.334 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.661825e-01 | 0.331 |
| R-HSA-9909396 | Circadian clock | 4.708785e-01 | 0.327 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.724428e-01 | 0.326 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.724428e-01 | 0.326 |
| R-HSA-182971 | EGFR downregulation | 4.724428e-01 | 0.326 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.724428e-01 | 0.326 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.774219e-01 | 0.321 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.774219e-01 | 0.321 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.814932e-01 | 0.317 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.814932e-01 | 0.317 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.814932e-01 | 0.317 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.814932e-01 | 0.317 |
| R-HSA-69190 | DNA strand elongation | 4.814932e-01 | 0.317 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.885164e-01 | 0.311 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.903889e-01 | 0.309 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.903889e-01 | 0.309 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.903889e-01 | 0.309 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.903889e-01 | 0.309 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.903889e-01 | 0.309 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.910398e-01 | 0.309 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.926672e-01 | 0.307 |
| R-HSA-163685 | Integration of energy metabolism | 4.926672e-01 | 0.307 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.940084e-01 | 0.306 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.969722e-01 | 0.304 |
| R-HSA-390522 | Striated Muscle Contraction | 4.991325e-01 | 0.302 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.991325e-01 | 0.302 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.991325e-01 | 0.302 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.991325e-01 | 0.302 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.991325e-01 | 0.302 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.991325e-01 | 0.302 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.991325e-01 | 0.302 |
| R-HSA-421270 | Cell-cell junction organization | 5.024786e-01 | 0.299 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.077266e-01 | 0.294 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.077266e-01 | 0.294 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.077266e-01 | 0.294 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.077266e-01 | 0.294 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.077266e-01 | 0.294 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.077266e-01 | 0.294 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.077266e-01 | 0.294 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.077266e-01 | 0.294 |
| R-HSA-5673000 | RAF activation | 5.077266e-01 | 0.294 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.102588e-01 | 0.292 |
| R-HSA-1632852 | Macroautophagy | 5.140067e-01 | 0.289 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.155994e-01 | 0.288 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.161738e-01 | 0.287 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.161738e-01 | 0.287 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.161738e-01 | 0.287 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.161738e-01 | 0.287 |
| R-HSA-169911 | Regulation of Apoptosis | 5.161738e-01 | 0.287 |
| R-HSA-187687 | Signalling to ERKs | 5.161738e-01 | 0.287 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.161738e-01 | 0.287 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.244765e-01 | 0.280 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.244765e-01 | 0.280 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.244765e-01 | 0.280 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.244765e-01 | 0.280 |
| R-HSA-8853659 | RET signaling | 5.244765e-01 | 0.280 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.307315e-01 | 0.275 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.313889e-01 | 0.275 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.326373e-01 | 0.274 |
| R-HSA-4641257 | Degradation of AXIN | 5.326373e-01 | 0.274 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.326373e-01 | 0.274 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.326373e-01 | 0.274 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.326373e-01 | 0.274 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.343317e-01 | 0.272 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.406585e-01 | 0.267 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.406585e-01 | 0.267 |
| R-HSA-212436 | Generic Transcription Pathway | 5.420714e-01 | 0.266 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.483519e-01 | 0.261 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.485426e-01 | 0.261 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.485426e-01 | 0.261 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.485426e-01 | 0.261 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.485426e-01 | 0.261 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.485426e-01 | 0.261 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.518914e-01 | 0.258 |
| R-HSA-1296071 | Potassium Channels | 5.518914e-01 | 0.258 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.562918e-01 | 0.255 |
| R-HSA-9646399 | Aggrephagy | 5.562918e-01 | 0.255 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.562918e-01 | 0.255 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.562918e-01 | 0.255 |
| R-HSA-167169 | HIV Transcription Elongation | 5.562918e-01 | 0.255 |
| R-HSA-5260271 | Diseases of Immune System | 5.562918e-01 | 0.255 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.562918e-01 | 0.255 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.562918e-01 | 0.255 |
| R-HSA-3371568 | Attenuation phase | 5.562918e-01 | 0.255 |
| R-HSA-202433 | Generation of second messenger molecules | 5.562918e-01 | 0.255 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.562918e-01 | 0.255 |
| R-HSA-157579 | Telomere Maintenance | 5.569177e-01 | 0.254 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.569177e-01 | 0.254 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.569177e-01 | 0.254 |
| R-HSA-422356 | Regulation of insulin secretion | 5.619039e-01 | 0.250 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.631935e-01 | 0.249 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.639084e-01 | 0.249 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.639084e-01 | 0.249 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.639084e-01 | 0.249 |
| R-HSA-3214847 | HATs acetylate histones | 5.668499e-01 | 0.247 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.668499e-01 | 0.247 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.713948e-01 | 0.243 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.713948e-01 | 0.243 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.713948e-01 | 0.243 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.713948e-01 | 0.243 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.713948e-01 | 0.243 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.717558e-01 | 0.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.743797e-01 | 0.241 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.766213e-01 | 0.239 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.787531e-01 | 0.238 |
| R-HSA-991365 | Activation of GABAB receptors | 5.787531e-01 | 0.238 |
| R-HSA-977444 | GABA B receptor activation | 5.787531e-01 | 0.238 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.814465e-01 | 0.235 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.859855e-01 | 0.232 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.859855e-01 | 0.232 |
| R-HSA-111885 | Opioid Signalling | 5.909755e-01 | 0.228 |
| R-HSA-2172127 | DAP12 interactions | 5.930942e-01 | 0.227 |
| R-HSA-9907900 | Proteasome assembly | 5.930942e-01 | 0.227 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.930942e-01 | 0.227 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.930942e-01 | 0.227 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.930942e-01 | 0.227 |
| R-HSA-69236 | G1 Phase | 5.930942e-01 | 0.227 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.942609e-01 | 0.226 |
| R-HSA-9833110 | RSV-host interactions | 5.956794e-01 | 0.225 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.980954e-01 | 0.223 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.000812e-01 | 0.222 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.000812e-01 | 0.222 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.000812e-01 | 0.222 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.000812e-01 | 0.222 |
| R-HSA-9824272 | Somitogenesis | 6.000812e-01 | 0.222 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.003427e-01 | 0.222 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.049656e-01 | 0.218 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.069487e-01 | 0.217 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.069487e-01 | 0.217 |
| R-HSA-9675135 | Diseases of DNA repair | 6.069487e-01 | 0.217 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.069487e-01 | 0.217 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.069487e-01 | 0.217 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.069487e-01 | 0.217 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.069487e-01 | 0.217 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.069487e-01 | 0.217 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.069487e-01 | 0.217 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.069487e-01 | 0.217 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.069487e-01 | 0.217 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.089752e-01 | 0.215 |
| R-HSA-69239 | Synthesis of DNA | 6.095480e-01 | 0.215 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.136987e-01 | 0.212 |
| R-HSA-437239 | Recycling pathway of L1 | 6.136987e-01 | 0.212 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.136987e-01 | 0.212 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.182308e-01 | 0.209 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.185915e-01 | 0.209 |
| R-HSA-9031628 | NGF-stimulated transcription | 6.203332e-01 | 0.207 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.203332e-01 | 0.207 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.203332e-01 | 0.207 |
| R-HSA-70263 | Gluconeogenesis | 6.203332e-01 | 0.207 |
| R-HSA-425410 | Metal ion SLC transporters | 6.203332e-01 | 0.207 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.268542e-01 | 0.203 |
| R-HSA-73893 | DNA Damage Bypass | 6.268542e-01 | 0.203 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.332635e-01 | 0.198 |
| R-HSA-109704 | PI3K Cascade | 6.332635e-01 | 0.198 |
| R-HSA-9748787 | Azathioprine ADME | 6.332635e-01 | 0.198 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.345816e-01 | 0.198 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.377639e-01 | 0.195 |
| R-HSA-418555 | G alpha (s) signalling events | 6.381062e-01 | 0.195 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.381062e-01 | 0.195 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.395632e-01 | 0.194 |
| R-HSA-912446 | Meiotic recombination | 6.395632e-01 | 0.194 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 6.395632e-01 | 0.194 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.395632e-01 | 0.194 |
| R-HSA-2514856 | The phototransduction cascade | 6.395632e-01 | 0.194 |
| R-HSA-72187 | mRNA 3'-end processing | 6.457550e-01 | 0.190 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.457550e-01 | 0.190 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.457550e-01 | 0.190 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.457550e-01 | 0.190 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.518408e-01 | 0.186 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.518408e-01 | 0.186 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.518408e-01 | 0.186 |
| R-HSA-72649 | Translation initiation complex formation | 6.578224e-01 | 0.182 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.578224e-01 | 0.182 |
| R-HSA-9753281 | Paracetamol ADME | 6.637016e-01 | 0.178 |
| R-HSA-2559583 | Cellular Senescence | 6.687560e-01 | 0.175 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.694802e-01 | 0.174 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.694802e-01 | 0.174 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.694802e-01 | 0.174 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.694858e-01 | 0.174 |
| R-HSA-112399 | IRS-mediated signalling | 6.751598e-01 | 0.171 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.772795e-01 | 0.169 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.774149e-01 | 0.169 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.807422e-01 | 0.167 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.807422e-01 | 0.167 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.807422e-01 | 0.167 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.851890e-01 | 0.164 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.851890e-01 | 0.164 |
| R-HSA-180786 | Extension of Telomeres | 6.862290e-01 | 0.164 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.862290e-01 | 0.164 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.862290e-01 | 0.164 |
| R-HSA-977443 | GABA receptor activation | 6.916218e-01 | 0.160 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.916218e-01 | 0.160 |
| R-HSA-983189 | Kinesins | 6.916218e-01 | 0.160 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.916218e-01 | 0.160 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.916218e-01 | 0.160 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.916218e-01 | 0.160 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.916218e-01 | 0.160 |
| R-HSA-351202 | Metabolism of polyamines | 6.916218e-01 | 0.160 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.916218e-01 | 0.160 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.916218e-01 | 0.160 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.916218e-01 | 0.160 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.943780e-01 | 0.158 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.965622e-01 | 0.157 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.965622e-01 | 0.157 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.965622e-01 | 0.157 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.969223e-01 | 0.157 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.969223e-01 | 0.157 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.969223e-01 | 0.157 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.969223e-01 | 0.157 |
| R-HSA-9824446 | Viral Infection Pathways | 6.972142e-01 | 0.157 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.002772e-01 | 0.155 |
| R-HSA-1268020 | Mitochondrial protein import | 7.021320e-01 | 0.154 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.021320e-01 | 0.154 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.021320e-01 | 0.154 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.027438e-01 | 0.153 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.072524e-01 | 0.150 |
| R-HSA-8848021 | Signaling by PTK6 | 7.072524e-01 | 0.150 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.072524e-01 | 0.150 |
| R-HSA-373755 | Semaphorin interactions | 7.072524e-01 | 0.150 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.075945e-01 | 0.150 |
| R-HSA-2428924 | IGF1R signaling cascade | 7.122851e-01 | 0.147 |
| R-HSA-74751 | Insulin receptor signalling cascade | 7.122851e-01 | 0.147 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.125974e-01 | 0.147 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.147625e-01 | 0.146 |
| R-HSA-9675108 | Nervous system development | 7.161663e-01 | 0.145 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.172317e-01 | 0.144 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 7.172317e-01 | 0.144 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.172317e-01 | 0.144 |
| R-HSA-9843745 | Adipogenesis | 7.217830e-01 | 0.142 |
| R-HSA-5576891 | Cardiac conduction | 7.217830e-01 | 0.142 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.268719e-01 | 0.139 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 7.268719e-01 | 0.139 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.299717e-01 | 0.137 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.315685e-01 | 0.136 |
| R-HSA-167172 | Transcription of the HIV genome | 7.315685e-01 | 0.136 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.335450e-01 | 0.135 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.407217e-01 | 0.130 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.407217e-01 | 0.130 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.407217e-01 | 0.130 |
| R-HSA-72172 | mRNA Splicing | 7.438142e-01 | 0.129 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.451810e-01 | 0.128 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.451810e-01 | 0.128 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 7.451810e-01 | 0.128 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.495638e-01 | 0.125 |
| R-HSA-597592 | Post-translational protein modification | 7.497006e-01 | 0.125 |
| R-HSA-418594 | G alpha (i) signalling events | 7.498386e-01 | 0.125 |
| R-HSA-4086398 | Ca2+ pathway | 7.538716e-01 | 0.123 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.538716e-01 | 0.123 |
| R-HSA-8852135 | Protein ubiquitination | 7.622668e-01 | 0.118 |
| R-HSA-422475 | Axon guidance | 7.632449e-01 | 0.117 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.663568e-01 | 0.116 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.663568e-01 | 0.116 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.703767e-01 | 0.113 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.743276e-01 | 0.111 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.743276e-01 | 0.111 |
| R-HSA-5619084 | ABC transporter disorders | 7.743276e-01 | 0.111 |
| R-HSA-216083 | Integrin cell surface interactions | 7.743276e-01 | 0.111 |
| R-HSA-166520 | Signaling by NTRKs | 7.814661e-01 | 0.107 |
| R-HSA-9833482 | PKR-mediated signaling | 7.820275e-01 | 0.107 |
| R-HSA-6806834 | Signaling by MET | 7.820275e-01 | 0.107 |
| R-HSA-5663205 | Infectious disease | 7.821887e-01 | 0.107 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.857787e-01 | 0.105 |
| R-HSA-977225 | Amyloid fiber formation | 7.857787e-01 | 0.105 |
| R-HSA-8951664 | Neddylation | 7.866913e-01 | 0.104 |
| R-HSA-72766 | Translation | 7.905540e-01 | 0.102 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.919491e-01 | 0.101 |
| R-HSA-69306 | DNA Replication | 7.951893e-01 | 0.100 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.966507e-01 | 0.099 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.966507e-01 | 0.099 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.978412e-01 | 0.098 |
| R-HSA-1989781 | PPARA activates gene expression | 8.004626e-01 | 0.097 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 8.035914e-01 | 0.095 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.056155e-01 | 0.094 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.069728e-01 | 0.093 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.081475e-01 | 0.093 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.102961e-01 | 0.091 |
| R-HSA-72312 | rRNA processing | 8.111521e-01 | 0.091 |
| R-HSA-156902 | Peptide chain elongation | 8.135624e-01 | 0.090 |
| R-HSA-9663891 | Selective autophagy | 8.135624e-01 | 0.090 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.135624e-01 | 0.090 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.199279e-01 | 0.086 |
| R-HSA-109582 | Hemostasis | 8.242099e-01 | 0.084 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.290723e-01 | 0.081 |
| R-HSA-391251 | Protein folding | 8.290723e-01 | 0.081 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.290723e-01 | 0.081 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.319459e-01 | 0.080 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.349100e-01 | 0.078 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.349100e-01 | 0.078 |
| R-HSA-1474290 | Collagen formation | 8.349100e-01 | 0.078 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.377540e-01 | 0.077 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.390278e-01 | 0.076 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.405491e-01 | 0.075 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.427521e-01 | 0.074 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.432962e-01 | 0.074 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.432962e-01 | 0.074 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.432962e-01 | 0.074 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.445597e-01 | 0.073 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.486498e-01 | 0.071 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.489571e-01 | 0.071 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.489571e-01 | 0.071 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.512578e-01 | 0.070 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.584247e-01 | 0.066 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.588163e-01 | 0.066 |
| R-HSA-1483255 | PI Metabolism | 8.588163e-01 | 0.066 |
| R-HSA-449147 | Signaling by Interleukins | 8.715321e-01 | 0.060 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.749975e-01 | 0.058 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.749975e-01 | 0.058 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.749975e-01 | 0.058 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.749975e-01 | 0.058 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.792714e-01 | 0.056 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.833998e-01 | 0.054 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.833998e-01 | 0.054 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.893300e-01 | 0.051 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.926093e-01 | 0.049 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.949596e-01 | 0.048 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.949596e-01 | 0.048 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.967720e-01 | 0.047 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.037153e-01 | 0.044 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.070104e-01 | 0.042 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.086156e-01 | 0.042 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.232242e-01 | 0.035 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.355045e-01 | 0.029 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.371031e-01 | 0.028 |
| R-HSA-1474244 | Extracellular matrix organization | 9.425357e-01 | 0.026 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.429160e-01 | 0.026 |
| R-HSA-2187338 | Visual phototransduction | 9.429160e-01 | 0.026 |
| R-HSA-9758941 | Gastrulation | 9.448732e-01 | 0.025 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.458266e-01 | 0.024 |
| R-HSA-392499 | Metabolism of proteins | 9.471006e-01 | 0.024 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.476843e-01 | 0.023 |
| R-HSA-9609507 | Protein localization | 9.485892e-01 | 0.023 |
| R-HSA-9711097 | Cellular response to starvation | 9.528851e-01 | 0.021 |
| R-HSA-416476 | G alpha (q) signalling events | 9.574228e-01 | 0.019 |
| R-HSA-1643685 | Disease | 9.579703e-01 | 0.019 |
| R-HSA-1280218 | Adaptive Immune System | 9.597008e-01 | 0.018 |
| R-HSA-168249 | Innate Immune System | 9.605897e-01 | 0.017 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.649876e-01 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 9.665369e-01 | 0.015 |
| R-HSA-3781865 | Diseases of glycosylation | 9.706024e-01 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 9.730308e-01 | 0.012 |
| R-HSA-983712 | Ion channel transport | 9.730636e-01 | 0.012 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.761258e-01 | 0.010 |
| R-HSA-428157 | Sphingolipid metabolism | 9.781648e-01 | 0.010 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.785437e-01 | 0.009 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.789160e-01 | 0.009 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.789160e-01 | 0.009 |
| R-HSA-6805567 | Keratinization | 9.803420e-01 | 0.009 |
| R-HSA-9748784 | Drug ADME | 9.840686e-01 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 9.856372e-01 | 0.006 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.868625e-01 | 0.006 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.870909e-01 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 9.910853e-01 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 9.937377e-01 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.941171e-01 | 0.003 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.944437e-01 | 0.002 |
| R-HSA-168256 | Immune System | 9.953025e-01 | 0.002 |
| R-HSA-8957322 | Metabolism of steroids | 9.975290e-01 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.987809e-01 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.995714e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.996078e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999291e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999871e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999977e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999997e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1D |
0.841 | 0.566 | -3 | 0.685 |
CK1E |
0.839 | 0.553 | -3 | 0.673 |
CK1A2 |
0.833 | 0.550 | -3 | 0.686 |
COT |
0.827 | 0.212 | 2 | 0.885 |
GRK1 |
0.823 | 0.300 | -2 | 0.784 |
CK1G1 |
0.822 | 0.488 | -3 | 0.646 |
CLK3 |
0.817 | 0.130 | 1 | 0.851 |
KIS |
0.816 | 0.177 | 1 | 0.750 |
CK1A |
0.815 | 0.486 | -3 | 0.700 |
DSTYK |
0.812 | 0.104 | 2 | 0.908 |
BMPR1B |
0.811 | 0.254 | 1 | 0.814 |
MOS |
0.810 | 0.139 | 1 | 0.868 |
IKKB |
0.808 | 0.092 | -2 | 0.724 |
CDC7 |
0.807 | 0.105 | 1 | 0.842 |
GRK6 |
0.807 | 0.276 | 1 | 0.828 |
PIM3 |
0.805 | 0.021 | -3 | 0.207 |
GRK7 |
0.802 | 0.203 | 1 | 0.761 |
MTOR |
0.802 | 0.029 | 1 | 0.796 |
GRK5 |
0.801 | 0.206 | -3 | 0.339 |
CAMK2G |
0.801 | 0.051 | 2 | 0.848 |
IKKA |
0.800 | 0.089 | -2 | 0.723 |
PRPK |
0.799 | -0.025 | -1 | 0.857 |
GRK4 |
0.799 | 0.217 | -2 | 0.826 |
CK1G3 |
0.798 | 0.475 | -3 | 0.699 |
MLK1 |
0.797 | 0.124 | 2 | 0.849 |
PIM1 |
0.797 | 0.026 | -3 | 0.203 |
GCN2 |
0.796 | -0.038 | 2 | 0.822 |
NLK |
0.796 | 0.042 | 1 | 0.856 |
BMPR2 |
0.796 | 0.067 | -2 | 0.870 |
BMPR1A |
0.796 | 0.214 | 1 | 0.793 |
RAF1 |
0.795 | -0.009 | 1 | 0.823 |
NEK7 |
0.795 | -0.000 | -3 | 0.225 |
NEK6 |
0.795 | -0.004 | -2 | 0.858 |
CDKL1 |
0.795 | -0.030 | -3 | 0.182 |
SRPK1 |
0.794 | 0.005 | -3 | 0.170 |
ACVR2B |
0.794 | 0.184 | -2 | 0.856 |
NDR2 |
0.794 | -0.025 | -3 | 0.196 |
ACVR2A |
0.794 | 0.197 | -2 | 0.846 |
TGFBR1 |
0.794 | 0.129 | -2 | 0.865 |
ERK5 |
0.792 | 0.037 | 1 | 0.824 |
FAM20C |
0.792 | 0.073 | 2 | 0.607 |
GRK3 |
0.792 | 0.212 | -2 | 0.679 |
TBK1 |
0.791 | -0.027 | 1 | 0.735 |
SRPK2 |
0.791 | -0.006 | -3 | 0.142 |
IKKE |
0.791 | -0.021 | 1 | 0.733 |
PKN3 |
0.790 | -0.040 | -3 | 0.178 |
ALK2 |
0.790 | 0.160 | -2 | 0.877 |
CAMK1B |
0.790 | -0.065 | -3 | 0.204 |
TGFBR2 |
0.790 | 0.025 | -2 | 0.857 |
PDHK4 |
0.789 | -0.150 | 1 | 0.838 |
GRK2 |
0.789 | 0.161 | -2 | 0.709 |
MST4 |
0.789 | 0.018 | 2 | 0.889 |
ULK2 |
0.789 | -0.101 | 2 | 0.792 |
RSK2 |
0.789 | -0.039 | -3 | 0.148 |
ALK4 |
0.788 | 0.125 | -2 | 0.875 |
NUAK2 |
0.788 | -0.032 | -3 | 0.205 |
CLK2 |
0.788 | 0.056 | -3 | 0.173 |
CDK1 |
0.788 | 0.102 | 1 | 0.707 |
SRPK3 |
0.787 | 0.002 | -3 | 0.182 |
ATR |
0.786 | -0.044 | 1 | 0.770 |
CDKL5 |
0.786 | -0.036 | -3 | 0.166 |
PLK1 |
0.786 | 0.055 | -2 | 0.832 |
DLK |
0.785 | 0.096 | 1 | 0.814 |
CAMK2B |
0.785 | 0.033 | 2 | 0.817 |
PKN2 |
0.784 | -0.031 | -3 | 0.200 |
SKMLCK |
0.784 | -0.029 | -2 | 0.782 |
NIK |
0.783 | -0.076 | -3 | 0.215 |
PDHK1 |
0.783 | -0.156 | 1 | 0.822 |
MAPKAPK2 |
0.783 | -0.042 | -3 | 0.125 |
ULK1 |
0.783 | -0.098 | -3 | 0.200 |
CHAK2 |
0.783 | -0.008 | -1 | 0.830 |
MLK4 |
0.782 | 0.105 | 2 | 0.765 |
HUNK |
0.782 | -0.063 | 2 | 0.793 |
CDK8 |
0.782 | 0.031 | 1 | 0.734 |
BCKDK |
0.782 | -0.048 | -1 | 0.803 |
CLK4 |
0.782 | 0.008 | -3 | 0.184 |
LATS1 |
0.782 | 0.002 | -3 | 0.178 |
P90RSK |
0.782 | -0.066 | -3 | 0.150 |
RIPK3 |
0.782 | -0.030 | 3 | 0.706 |
CK2A2 |
0.781 | 0.157 | 1 | 0.762 |
ICK |
0.781 | -0.032 | -3 | 0.189 |
LATS2 |
0.781 | -0.047 | -5 | 0.741 |
ANKRD3 |
0.781 | -0.002 | 1 | 0.829 |
JNK3 |
0.781 | 0.084 | 1 | 0.724 |
PKCD |
0.780 | -0.021 | 2 | 0.841 |
MLK3 |
0.780 | 0.035 | 2 | 0.797 |
NDR1 |
0.780 | -0.081 | -3 | 0.182 |
PRKD1 |
0.780 | -0.077 | -3 | 0.141 |
CAMK2A |
0.780 | 0.000 | 2 | 0.848 |
ATM |
0.779 | -0.002 | 1 | 0.697 |
PRKX |
0.779 | -0.007 | -3 | 0.151 |
PRKD2 |
0.779 | -0.074 | -3 | 0.125 |
NEK9 |
0.779 | -0.068 | 2 | 0.854 |
RSK4 |
0.779 | -0.025 | -3 | 0.153 |
CAMK2D |
0.779 | -0.070 | -3 | 0.166 |
WNK1 |
0.779 | -0.064 | -2 | 0.792 |
P70S6KB |
0.778 | -0.067 | -3 | 0.164 |
CAMLCK |
0.778 | -0.080 | -2 | 0.778 |
TTBK2 |
0.778 | 0.007 | 2 | 0.698 |
CDK5 |
0.778 | 0.071 | 1 | 0.750 |
RSK3 |
0.777 | -0.080 | -3 | 0.137 |
DAPK2 |
0.777 | -0.091 | -3 | 0.200 |
MEKK3 |
0.777 | 0.169 | 1 | 0.784 |
HIPK4 |
0.777 | -0.034 | 1 | 0.790 |
JNK2 |
0.777 | 0.079 | 1 | 0.693 |
YSK4 |
0.776 | 0.009 | 1 | 0.763 |
CDK19 |
0.776 | 0.030 | 1 | 0.700 |
MARK4 |
0.776 | -0.078 | 4 | 0.829 |
PKR |
0.776 | 0.029 | 1 | 0.800 |
CK1G2 |
0.776 | 0.395 | -3 | 0.676 |
PRP4 |
0.776 | 0.010 | -3 | 0.219 |
MEK1 |
0.776 | 0.082 | 2 | 0.828 |
MSK2 |
0.775 | -0.063 | -3 | 0.167 |
CLK1 |
0.775 | -0.009 | -3 | 0.147 |
PLK3 |
0.775 | 0.002 | 2 | 0.781 |
DYRK2 |
0.775 | 0.020 | 1 | 0.739 |
PKACG |
0.775 | -0.052 | -2 | 0.646 |
AMPKA1 |
0.774 | -0.084 | -3 | 0.194 |
P38G |
0.774 | 0.080 | 1 | 0.628 |
CDK18 |
0.773 | 0.061 | 1 | 0.679 |
MASTL |
0.773 | -0.147 | -2 | 0.773 |
CK2A1 |
0.773 | 0.156 | 1 | 0.745 |
PKACB |
0.773 | -0.030 | -2 | 0.583 |
MAPKAPK3 |
0.773 | -0.114 | -3 | 0.127 |
CDK13 |
0.772 | 0.038 | 1 | 0.715 |
ERK1 |
0.772 | 0.067 | 1 | 0.695 |
CDK2 |
0.771 | 0.052 | 1 | 0.772 |
MSK1 |
0.771 | -0.044 | -3 | 0.152 |
MLK2 |
0.771 | -0.088 | 2 | 0.832 |
PKCB |
0.770 | -0.020 | 2 | 0.795 |
P38B |
0.770 | 0.066 | 1 | 0.703 |
HIPK2 |
0.770 | 0.040 | 1 | 0.668 |
CDK3 |
0.770 | 0.080 | 1 | 0.652 |
AURC |
0.769 | -0.031 | -2 | 0.566 |
HIPK1 |
0.769 | 0.026 | 1 | 0.759 |
TLK2 |
0.769 | 0.012 | 1 | 0.737 |
RIPK1 |
0.768 | -0.100 | 1 | 0.773 |
P38A |
0.768 | 0.046 | 1 | 0.760 |
AKT2 |
0.768 | -0.054 | -3 | 0.142 |
WNK3 |
0.768 | -0.177 | 1 | 0.777 |
AMPKA2 |
0.768 | -0.092 | -3 | 0.172 |
IRE1 |
0.768 | -0.043 | 1 | 0.744 |
PASK |
0.768 | 0.035 | -3 | 0.233 |
PLK2 |
0.767 | 0.040 | -3 | 0.245 |
PKCG |
0.767 | -0.028 | 2 | 0.792 |
MYLK4 |
0.767 | -0.041 | -2 | 0.691 |
CDK17 |
0.767 | 0.056 | 1 | 0.633 |
GAK |
0.767 | 0.157 | 1 | 0.851 |
PKCA |
0.767 | -0.025 | 2 | 0.791 |
ERK2 |
0.766 | 0.050 | 1 | 0.727 |
MST3 |
0.766 | 0.090 | 2 | 0.867 |
PIM2 |
0.766 | -0.046 | -3 | 0.145 |
MEKK2 |
0.766 | 0.102 | 2 | 0.811 |
P38D |
0.766 | 0.081 | 1 | 0.632 |
TSSK2 |
0.765 | -0.081 | -5 | 0.811 |
CAMK4 |
0.765 | -0.119 | -3 | 0.193 |
NUAK1 |
0.765 | -0.103 | -3 | 0.148 |
VRK2 |
0.765 | -0.130 | 1 | 0.844 |
CDK7 |
0.765 | 0.004 | 1 | 0.740 |
TLK1 |
0.764 | 0.061 | -2 | 0.860 |
MEKK1 |
0.764 | -0.020 | 1 | 0.782 |
PRKD3 |
0.764 | -0.100 | -3 | 0.129 |
ZAK |
0.764 | 0.009 | 1 | 0.767 |
TAO3 |
0.764 | 0.037 | 1 | 0.782 |
DRAK1 |
0.764 | -0.018 | 1 | 0.783 |
QSK |
0.763 | -0.070 | 4 | 0.804 |
GSK3A |
0.763 | 0.060 | 4 | 0.538 |
AURA |
0.763 | -0.022 | -2 | 0.551 |
PHKG1 |
0.763 | -0.079 | -3 | 0.187 |
BRAF |
0.763 | -0.041 | -4 | 0.836 |
CDK12 |
0.763 | 0.028 | 1 | 0.691 |
SIK |
0.763 | -0.088 | -3 | 0.157 |
PERK |
0.763 | -0.027 | -2 | 0.868 |
PAK1 |
0.763 | -0.084 | -2 | 0.688 |
SGK3 |
0.762 | -0.069 | -3 | 0.149 |
TSSK1 |
0.762 | -0.096 | -3 | 0.190 |
DYRK4 |
0.762 | 0.034 | 1 | 0.687 |
NIM1 |
0.761 | -0.115 | 3 | 0.771 |
PKCH |
0.761 | -0.059 | 2 | 0.771 |
DNAPK |
0.761 | -0.031 | 1 | 0.642 |
IRE2 |
0.760 | -0.075 | 2 | 0.775 |
NEK2 |
0.760 | -0.121 | 2 | 0.832 |
BRSK1 |
0.760 | -0.090 | -3 | 0.154 |
PINK1 |
0.760 | -0.113 | 1 | 0.827 |
DYRK1A |
0.760 | -0.026 | 1 | 0.777 |
QIK |
0.760 | -0.123 | -3 | 0.187 |
CAMK1G |
0.759 | -0.088 | -3 | 0.159 |
CDK14 |
0.759 | 0.040 | 1 | 0.720 |
PKCZ |
0.759 | -0.065 | 2 | 0.812 |
NEK5 |
0.758 | -0.058 | 1 | 0.785 |
MEK5 |
0.758 | -0.053 | 2 | 0.828 |
CDK10 |
0.758 | 0.050 | 1 | 0.708 |
CDK16 |
0.758 | 0.054 | 1 | 0.647 |
MARK3 |
0.758 | -0.059 | 4 | 0.765 |
JNK1 |
0.758 | 0.064 | 1 | 0.687 |
HRI |
0.758 | -0.093 | -2 | 0.852 |
AURB |
0.757 | -0.054 | -2 | 0.566 |
MST2 |
0.757 | 0.043 | 1 | 0.788 |
CDK9 |
0.757 | 0.000 | 1 | 0.721 |
GSK3B |
0.757 | 0.036 | 4 | 0.528 |
MARK2 |
0.756 | -0.071 | 4 | 0.731 |
CHAK1 |
0.756 | -0.106 | 2 | 0.764 |
MELK |
0.756 | -0.146 | -3 | 0.146 |
DYRK1B |
0.756 | 0.008 | 1 | 0.716 |
DCAMKL1 |
0.756 | -0.100 | -3 | 0.158 |
SMG1 |
0.756 | -0.082 | 1 | 0.709 |
PAK3 |
0.756 | -0.124 | -2 | 0.689 |
PLK4 |
0.755 | -0.055 | 2 | 0.608 |
AKT1 |
0.755 | -0.060 | -3 | 0.138 |
PKACA |
0.755 | -0.060 | -2 | 0.529 |
TAK1 |
0.755 | 0.104 | 1 | 0.794 |
DYRK3 |
0.755 | -0.016 | 1 | 0.752 |
GCK |
0.754 | 0.040 | 1 | 0.793 |
CAMKK1 |
0.754 | -0.052 | -2 | 0.755 |
MNK2 |
0.754 | -0.105 | -2 | 0.694 |
PKG2 |
0.754 | -0.080 | -2 | 0.573 |
MNK1 |
0.753 | -0.093 | -2 | 0.702 |
NEK8 |
0.753 | -0.020 | 2 | 0.844 |
HIPK3 |
0.753 | -0.023 | 1 | 0.750 |
NEK11 |
0.753 | -0.011 | 1 | 0.789 |
PAK2 |
0.753 | -0.101 | -2 | 0.677 |
CHK1 |
0.753 | -0.146 | -3 | 0.130 |
MAPKAPK5 |
0.752 | -0.150 | -3 | 0.126 |
ERK7 |
0.752 | 0.048 | 2 | 0.626 |
MARK1 |
0.751 | -0.090 | 4 | 0.786 |
MPSK1 |
0.751 | -0.017 | 1 | 0.784 |
SGK1 |
0.751 | -0.052 | -3 | 0.115 |
SMMLCK |
0.751 | -0.092 | -3 | 0.176 |
EEF2K |
0.750 | 0.040 | 3 | 0.825 |
MAK |
0.750 | 0.008 | -2 | 0.642 |
BRSK2 |
0.749 | -0.139 | -3 | 0.157 |
P70S6K |
0.749 | -0.096 | -3 | 0.121 |
DAPK3 |
0.749 | -0.052 | -3 | 0.188 |
CAMK1D |
0.749 | -0.098 | -3 | 0.118 |
TTBK1 |
0.749 | -0.053 | 2 | 0.620 |
MINK |
0.748 | 0.021 | 1 | 0.774 |
YANK3 |
0.747 | 0.128 | 2 | 0.415 |
TAO2 |
0.747 | -0.066 | 2 | 0.881 |
AKT3 |
0.747 | -0.056 | -3 | 0.119 |
PAK6 |
0.747 | -0.098 | -2 | 0.618 |
PKCT |
0.747 | -0.075 | 2 | 0.778 |
PKCE |
0.746 | -0.028 | 2 | 0.779 |
DAPK1 |
0.746 | -0.038 | -3 | 0.200 |
CAMKK2 |
0.746 | -0.082 | -2 | 0.736 |
HPK1 |
0.746 | 0.021 | 1 | 0.781 |
DCAMKL2 |
0.745 | -0.114 | -3 | 0.155 |
WNK4 |
0.745 | -0.129 | -2 | 0.789 |
TNIK |
0.745 | -0.009 | 3 | 0.854 |
LKB1 |
0.744 | -0.097 | -3 | 0.198 |
IRAK4 |
0.744 | -0.109 | 1 | 0.747 |
PHKG2 |
0.744 | -0.110 | -3 | 0.164 |
PKCI |
0.744 | -0.061 | 2 | 0.788 |
SNRK |
0.743 | -0.197 | 2 | 0.682 |
PDK1 |
0.743 | -0.078 | 1 | 0.789 |
CHK2 |
0.743 | -0.092 | -3 | 0.112 |
CDK6 |
0.743 | 0.031 | 1 | 0.700 |
MST1 |
0.742 | -0.021 | 1 | 0.770 |
TTK |
0.742 | 0.110 | -2 | 0.853 |
PDHK3_TYR |
0.741 | 0.135 | 4 | 0.911 |
HGK |
0.741 | -0.046 | 3 | 0.847 |
KHS2 |
0.741 | 0.030 | 1 | 0.778 |
MAP2K6_TYR |
0.740 | 0.238 | -1 | 0.894 |
SSTK |
0.740 | -0.090 | 4 | 0.789 |
PDHK4_TYR |
0.740 | 0.196 | 2 | 0.895 |
BMPR2_TYR |
0.740 | 0.134 | -1 | 0.916 |
OSR1 |
0.739 | 0.051 | 2 | 0.808 |
SBK |
0.739 | -0.074 | -3 | 0.082 |
ALPHAK3 |
0.739 | 0.108 | -1 | 0.798 |
NEK4 |
0.738 | -0.116 | 1 | 0.753 |
MAP3K15 |
0.738 | -0.065 | 1 | 0.751 |
PDHK1_TYR |
0.738 | 0.184 | -1 | 0.909 |
LRRK2 |
0.737 | -0.109 | 2 | 0.865 |
CDK4 |
0.736 | 0.014 | 1 | 0.678 |
SLK |
0.736 | -0.050 | -2 | 0.639 |
KHS1 |
0.736 | -0.024 | 1 | 0.763 |
PKN1 |
0.735 | -0.093 | -3 | 0.127 |
CAMK1A |
0.735 | -0.098 | -3 | 0.107 |
ROCK2 |
0.735 | -0.063 | -3 | 0.169 |
MOK |
0.734 | -0.027 | 1 | 0.751 |
NEK1 |
0.734 | -0.141 | 1 | 0.759 |
IRAK1 |
0.734 | -0.187 | -1 | 0.718 |
MRCKB |
0.734 | -0.080 | -3 | 0.144 |
MAP2K4_TYR |
0.734 | 0.102 | -1 | 0.878 |
MRCKA |
0.733 | -0.082 | -3 | 0.147 |
MEKK6 |
0.733 | -0.133 | 1 | 0.763 |
VRK1 |
0.732 | -0.114 | 2 | 0.823 |
DMPK1 |
0.731 | -0.050 | -3 | 0.165 |
LOK |
0.730 | -0.104 | -2 | 0.689 |
STK33 |
0.730 | -0.086 | 2 | 0.624 |
PBK |
0.729 | -0.033 | 1 | 0.778 |
YSK1 |
0.728 | -0.072 | 2 | 0.840 |
TESK1_TYR |
0.728 | -0.041 | 3 | 0.867 |
MAP2K7_TYR |
0.727 | -0.056 | 2 | 0.865 |
PAK5 |
0.726 | -0.116 | -2 | 0.550 |
MEK2 |
0.726 | -0.194 | 2 | 0.790 |
RIPK2 |
0.725 | -0.177 | 1 | 0.730 |
EPHA6 |
0.725 | 0.028 | -1 | 0.896 |
PKMYT1_TYR |
0.725 | -0.062 | 3 | 0.829 |
PINK1_TYR |
0.725 | -0.035 | 1 | 0.820 |
TXK |
0.725 | 0.108 | 1 | 0.836 |
YANK2 |
0.723 | 0.145 | 2 | 0.434 |
PAK4 |
0.722 | -0.106 | -2 | 0.559 |
SYK |
0.721 | 0.191 | -1 | 0.850 |
HASPIN |
0.721 | -0.023 | -1 | 0.664 |
CRIK |
0.721 | -0.073 | -3 | 0.126 |
EPHB4 |
0.720 | 0.008 | -1 | 0.854 |
ROCK1 |
0.720 | -0.079 | -3 | 0.152 |
FGR |
0.720 | 0.084 | 1 | 0.825 |
BIKE |
0.720 | 0.004 | 1 | 0.750 |
MYO3A |
0.718 | -0.042 | 1 | 0.750 |
PTK2 |
0.718 | 0.140 | -1 | 0.872 |
BUB1 |
0.718 | -0.084 | -5 | 0.754 |
FLT1 |
0.717 | 0.111 | -1 | 0.882 |
NEK3 |
0.717 | -0.172 | 1 | 0.730 |
INSRR |
0.717 | 0.032 | 3 | 0.718 |
ASK1 |
0.717 | -0.096 | 1 | 0.745 |
EPHA4 |
0.716 | 0.000 | 2 | 0.786 |
MYO3B |
0.716 | -0.070 | 2 | 0.849 |
RET |
0.716 | -0.079 | 1 | 0.769 |
LCK |
0.716 | 0.050 | -1 | 0.836 |
BLK |
0.716 | 0.064 | -1 | 0.840 |
JAK3 |
0.715 | -0.000 | 1 | 0.760 |
FER |
0.715 | -0.002 | 1 | 0.832 |
FYN |
0.715 | 0.097 | -1 | 0.825 |
ABL2 |
0.714 | 0.018 | -1 | 0.793 |
KIT |
0.714 | 0.043 | 3 | 0.764 |
TYK2 |
0.713 | -0.104 | 1 | 0.767 |
YES1 |
0.713 | -0.009 | -1 | 0.817 |
CSF1R |
0.713 | -0.026 | 3 | 0.763 |
LIMK2_TYR |
0.712 | -0.154 | -3 | 0.184 |
HCK |
0.712 | 0.003 | -1 | 0.821 |
EPHB2 |
0.711 | 0.006 | -1 | 0.839 |
JAK2 |
0.711 | -0.090 | 1 | 0.768 |
TAO1 |
0.711 | -0.098 | 1 | 0.708 |
MST1R |
0.711 | -0.101 | 3 | 0.785 |
SRMS |
0.711 | -0.012 | 1 | 0.822 |
MET |
0.710 | 0.053 | 3 | 0.753 |
ROS1 |
0.710 | -0.100 | 3 | 0.755 |
PKG1 |
0.710 | -0.120 | -2 | 0.489 |
STLK3 |
0.710 | -0.078 | 1 | 0.726 |
EPHB1 |
0.710 | -0.032 | 1 | 0.814 |
ABL1 |
0.710 | 0.012 | -1 | 0.778 |
LIMK1_TYR |
0.709 | -0.203 | 2 | 0.859 |
KDR |
0.709 | 0.002 | 3 | 0.717 |
EPHB3 |
0.709 | -0.025 | -1 | 0.836 |
TYRO3 |
0.708 | -0.106 | 3 | 0.781 |
FLT3 |
0.707 | -0.035 | 3 | 0.771 |
ITK |
0.707 | -0.033 | -1 | 0.780 |
ERBB2 |
0.706 | 0.015 | 1 | 0.745 |
FGFR2 |
0.706 | -0.050 | 3 | 0.757 |
BMX |
0.706 | 0.010 | -1 | 0.711 |
EGFR |
0.704 | 0.033 | 1 | 0.661 |
ZAP70 |
0.703 | 0.156 | -1 | 0.769 |
DDR1 |
0.703 | -0.177 | 4 | 0.808 |
FGFR3 |
0.702 | 0.000 | 3 | 0.726 |
AAK1 |
0.702 | 0.018 | 1 | 0.659 |
PDGFRB |
0.701 | -0.112 | 3 | 0.780 |
MATK |
0.701 | 0.014 | -1 | 0.737 |
EPHA7 |
0.701 | -0.040 | 2 | 0.787 |
SRC |
0.700 | 0.028 | -1 | 0.802 |
EPHA3 |
0.700 | -0.045 | 2 | 0.761 |
TNNI3K_TYR |
0.700 | -0.068 | 1 | 0.776 |
WEE1_TYR |
0.700 | -0.032 | -1 | 0.729 |
TEC |
0.699 | -0.051 | -1 | 0.688 |
EPHA5 |
0.699 | 0.001 | 2 | 0.771 |
NTRK1 |
0.699 | -0.077 | -1 | 0.824 |
EPHA8 |
0.699 | -0.004 | -1 | 0.839 |
ERBB4 |
0.699 | 0.093 | 1 | 0.686 |
LYN |
0.699 | -0.011 | 3 | 0.681 |
FGFR4 |
0.699 | 0.033 | -1 | 0.787 |
JAK1 |
0.698 | -0.088 | 1 | 0.724 |
FGFR1 |
0.698 | -0.099 | 3 | 0.736 |
TNK2 |
0.697 | -0.112 | 3 | 0.728 |
FRK |
0.697 | -0.024 | -1 | 0.826 |
MERTK |
0.696 | -0.060 | 3 | 0.737 |
NEK10_TYR |
0.696 | -0.127 | 1 | 0.671 |
BTK |
0.696 | -0.120 | -1 | 0.715 |
INSR |
0.696 | -0.055 | 3 | 0.698 |
TEK |
0.695 | -0.137 | 3 | 0.710 |
NTRK3 |
0.695 | -0.056 | -1 | 0.781 |
FLT4 |
0.695 | -0.065 | 3 | 0.706 |
NTRK2 |
0.692 | -0.115 | 3 | 0.721 |
PTK2B |
0.691 | -0.043 | -1 | 0.735 |
ALK |
0.690 | -0.124 | 3 | 0.692 |
PTK6 |
0.690 | -0.141 | -1 | 0.692 |
AXL |
0.690 | -0.143 | 3 | 0.745 |
EPHA2 |
0.689 | -0.017 | -1 | 0.816 |
PDGFRA |
0.689 | -0.195 | 3 | 0.777 |
LTK |
0.688 | -0.126 | 3 | 0.709 |
IGF1R |
0.686 | -0.021 | 3 | 0.636 |
CSK |
0.686 | -0.057 | 2 | 0.787 |
DDR2 |
0.686 | -0.108 | 3 | 0.700 |
TNK1 |
0.685 | -0.197 | 3 | 0.755 |
EPHA1 |
0.685 | -0.127 | 3 | 0.728 |
MUSK |
0.674 | -0.107 | 1 | 0.648 |
FES |
0.672 | -0.025 | -1 | 0.685 |