Motif 647 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | S89 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| E9PAV3 | NACA | S2054 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O14745 | NHERF1 | S77 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14967 | CLGN | S591 | ochoa | Calmegin | Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}. |
| O14974 | PPP1R12A | S432 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O43148 | RNMT | S70 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43847 | NRDC | S94 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O43847 | NRDC | S96 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60271 | SPAG9 | S268 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60701 | UGDH | S88 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60716 | CTNND1 | S847 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75152 | ZC3H11A | S119 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O95436 | SLC34A2 | S671 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| O95490 | ADGRL2 | S1353 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| P04920 | SLC4A2 | S132 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P06748 | NPM1 | S137 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07237 | P4HB | S427 | ochoa|psp | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07355 | ANXA2 | S89 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08172 | CHRM2 | S309 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P10645 | CHGA | S333 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P12830 | CDH1 | S770 | ochoa | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P12882 | MYH1 | S1331 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1714 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1710 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1712 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1713 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P18858 | LIG1 | S76 | ochoa|psp | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P21359 | NF1 | S2587 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P22001 | KCNA3 | Y499 | psp | Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) | [Isoform 1]: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:36852591}.; FUNCTION: [Isoform 2]: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:1373731, ECO:0000269|PubMed:1547020, ECO:0000269|PubMed:1986382, ECO:0000269|PubMed:36852591}.; FUNCTION: [Isoform 3]: Lacks voltage-gated potassium channel activity. {ECO:0000269|PubMed:36852591}. |
| P23327 | HRC | S96 | ochoa|psp | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P28290 | ITPRID2 | S437 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29374 | ARID4A | S827 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P34910 | EVI2B | S268 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35251 | RFC1 | S1076 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P42695 | NCAPD3 | S1370 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46100 | ATRX | S692 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S889 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S339 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S831 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P50851 | LRBA | S1003 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P53350 | PLK1 | S375 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P54198 | HIRA | S675 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P60880 | SNAP25 | S154 | ochoa | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}. |
| P68104 | EEF1A1 | S300 | ochoa|psp | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P78559 | MAP1A | S117 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P83111 | LACTB | S207 | ochoa | Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-) | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). {ECO:0000269|PubMed:28329758}. |
| Q03188 | CENPC | S158 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05639 | EEF1A2 | S300 | ochoa | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q07021 | C1QBP | S201 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q0ZGT2 | NEXN | S241 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12830 | BPTF | S1373 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12888 | TP53BP1 | S818 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S831 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q14008 | CKAP5 | S1861 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14103 | HNRNPD | S71 | ochoa | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q14116 | IL18 | S35 | ochoa | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) | Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993714}. |
| Q14151 | SAFB2 | S262 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14157 | UBAP2L | S254 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14699 | RFTN1 | S485 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q15054 | POLD3 | S423 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15057 | ACAP2 | S379 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15058 | KIF14 | S346 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15326 | ZMYND11 | S419 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15424 | SAFB | S263 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q5JQS6 | GCSAML | S116 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5SY16 | NOL9 | S105 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T200 | ZC3H13 | S1404 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5X7 | BEND3 | S33 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5UIP0 | RIF1 | S1760 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1974 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q6ZU35 | CRACD | S28 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q7RTP6 | MICAL3 | S506 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z3S7 | CACNA2D4 | S498 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z417 | NUFIP2 | S112 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z4H7 | HAUS6 | S447 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z6Z7 | HUWE1 | S2963 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7E8 | UBE2Q1 | S217 | ochoa | Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) | Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}. |
| Q86VY9 | TMEM200A | S362 | ochoa | Transmembrane protein 200A | None |
| Q86XP3 | DDX42 | S185 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q86YV5 | PRAG1 | S651 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IW35 | CEP97 | S752 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWZ3 | ANKHD1 | S1658 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IXS8 | HYCC2 | S430 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8IZ21 | PHACTR4 | S487 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8NCF5 | NFATC2IP | S161 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NCN4 | RNF169 | S520 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NFY4 | SEMA6D | S711 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8WUX9 | CHMP7 | S429 | ochoa | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Q8WWM7 | ATXN2L | S589 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWQ0 | PHIP | S1762 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92614 | MYO18A | S1527 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q93045 | STMN2 | S50 | psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q93074 | MED12 | S552 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96AC1 | FERMT2 | S351 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96C19 | EFHD2 | S192 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96CJ1 | EAF2 | S134 | ochoa | ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) | Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652, ECO:0000269|PubMed:16006523}. |
| Q96QT4 | TRPM7 | S1476 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RT1 | ERBIN | S557 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96T23 | RSF1 | S1398 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T58 | SPEN | S2154 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99460 | PSMD1 | S305 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99661 | KIF2C | S175 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99808 | SLC29A1 | S254 | ochoa|psp | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BSC4 | NOL10 | S607 | ochoa | Nucleolar protein 10 | None |
| Q9BV36 | MLPH | S252 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BY43 | CHMP4A | S193 | ochoa | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}. |
| Q9C0B1 | FTO | S260 | ochoa | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9GZZ9 | UBA5 | S358 | ochoa | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q9H1A4 | ANAPC1 | S286 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H2D6 | TRIOBP | S1983 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H3Q1 | CDC42EP4 | S105 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9NRR4 | DROSHA | S373 | ochoa | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NVR5 | DNAAF2 | S787 | ochoa | Protein kintoun (Dynein assembly factor 2, axonemal) | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}. |
| Q9NWV8 | BABAM1 | S57 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NX94 | WBP1L | S227 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NZ53 | PODXL2 | S570 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9UDY2 | TJP2 | S1171 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGP4 | LIMD1 | S656 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHB6 | LIMA1 | S326 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UKV3 | ACIN1 | S376 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1716 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULQ1 | TPCN1 | S796 | ochoa | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}. |
| Q9ULU4 | ZMYND8 | S533 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S535 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9Y520 | PRRC2C | S917 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y520 | PRRC2C | S1280 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| O75821 | EIF3G | S28 | Sugiyama | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P30533 | LRPAP1 | S230 | Sugiyama | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P50990 | CCT8 | S373 | Sugiyama | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| O15111 | CHUK | S351 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P20248 | CCNA2 | S130 | Sugiyama | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| Q9BXP5 | SRRT | S703 | Sugiyama | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q07666 | KHDRBS1 | S150 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| P34896 | SHMT1 | S381 | Sugiyama | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}. |
| Q12906 | ILF3 | S36 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| P13674 | P4HA1 | S383 | Sugiyama | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
| Q04637 | EIF4G1 | S1246 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q92878 | RAD50 | S623 | Sugiyama | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q9UBS0 | RPS6KB2 | S54 | Sugiyama | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 8.135302e-08 | 7.090 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.032607e-05 | 4.986 |
| R-HSA-73886 | Chromosome Maintenance | 4.468145e-05 | 4.350 |
| R-HSA-9012546 | Interleukin-18 signaling | 1.630091e-04 | 3.788 |
| R-HSA-69239 | Synthesis of DNA | 1.410056e-04 | 3.851 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.072839e-04 | 3.512 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.447832e-04 | 3.264 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 7.554251e-04 | 3.122 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.806723e-04 | 3.108 |
| R-HSA-69275 | G2/M Transition | 7.336054e-04 | 3.135 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.373369e-03 | 2.862 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 9.330894e-04 | 3.030 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 9.330894e-04 | 3.030 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.196824e-03 | 2.922 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.258025e-03 | 2.900 |
| R-HSA-69242 | S Phase | 1.010281e-03 | 2.996 |
| R-HSA-69306 | DNA Replication | 1.196824e-03 | 2.922 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.081928e-03 | 2.966 |
| R-HSA-5357801 | Programmed Cell Death | 1.323378e-03 | 2.878 |
| R-HSA-5693538 | Homology Directed Repair | 1.589482e-03 | 2.799 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.943992e-03 | 2.711 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.827842e-03 | 2.738 |
| R-HSA-68882 | Mitotic Anaphase | 1.780748e-03 | 2.749 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.979951e-03 | 2.703 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.162347e-03 | 2.665 |
| R-HSA-176417 | Phosphorylation of Emi1 | 2.626560e-03 | 2.581 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.689783e-03 | 2.570 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.850142e-03 | 2.545 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.190258e-03 | 2.496 |
| R-HSA-157579 | Telomere Maintenance | 3.597396e-03 | 2.444 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.480170e-03 | 2.458 |
| R-HSA-180786 | Extension of Telomeres | 3.750777e-03 | 2.426 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.035558e-03 | 2.394 |
| R-HSA-5620971 | Pyroptosis | 4.118346e-03 | 2.385 |
| R-HSA-68886 | M Phase | 4.731864e-03 | 2.325 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.876010e-03 | 2.312 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 4.876010e-03 | 2.312 |
| R-HSA-69190 | DNA strand elongation | 5.596592e-03 | 2.252 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.596592e-03 | 2.252 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.596592e-03 | 2.252 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.009545e-03 | 2.221 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 6.728066e-03 | 2.172 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.950999e-03 | 2.158 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.503479e-03 | 2.187 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.501596e-03 | 2.125 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.253482e-03 | 2.139 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.564530e-03 | 2.121 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 7.755766e-03 | 2.110 |
| R-HSA-69091 | Polymerase switching | 1.000794e-02 | 2.000 |
| R-HSA-69109 | Leading Strand Synthesis | 1.000794e-02 | 2.000 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 9.989729e-03 | 2.000 |
| R-HSA-73894 | DNA Repair | 9.637804e-03 | 2.016 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.054641e-02 | 1.977 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.199922e-02 | 1.921 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.199922e-02 | 1.921 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.114442e-02 | 1.953 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.116685e-02 | 1.952 |
| R-HSA-69481 | G2/M Checkpoints | 1.101771e-02 | 1.958 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.251392e-02 | 1.903 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.385896e-02 | 1.858 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.372974e-02 | 1.862 |
| R-HSA-774815 | Nucleosome assembly | 1.372974e-02 | 1.862 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.442483e-02 | 1.841 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.425129e-02 | 1.846 |
| R-HSA-75153 | Apoptotic execution phase | 1.442483e-02 | 1.841 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.526372e-02 | 1.816 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.526372e-02 | 1.816 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.526372e-02 | 1.816 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.845874e-02 | 1.734 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.845874e-02 | 1.734 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.845874e-02 | 1.734 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 1.845874e-02 | 1.734 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.845874e-02 | 1.734 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.845874e-02 | 1.734 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.824758e-02 | 1.739 |
| R-HSA-9766229 | Degradation of CDH1 | 1.662824e-02 | 1.779 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.900990e-02 | 1.721 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.593848e-02 | 1.798 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.982432e-02 | 1.703 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.824758e-02 | 1.739 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.824758e-02 | 1.739 |
| R-HSA-5358508 | Mismatch Repair | 1.982432e-02 | 1.703 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.982432e-02 | 1.703 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.982432e-02 | 1.703 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.984356e-02 | 1.702 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.157070e-02 | 1.666 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.210001e-02 | 1.656 |
| R-HSA-446728 | Cell junction organization | 2.226125e-02 | 1.652 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.246419e-02 | 1.649 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 2.756078e-02 | 1.560 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.756078e-02 | 1.560 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 2.756078e-02 | 1.560 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.756078e-02 | 1.560 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.657898e-02 | 1.437 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.657898e-02 | 1.437 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.657898e-02 | 1.437 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.657898e-02 | 1.437 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 3.657898e-02 | 1.437 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.657898e-02 | 1.437 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.657898e-02 | 1.437 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.657898e-02 | 1.437 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.657898e-02 | 1.437 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.657898e-02 | 1.437 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.657898e-02 | 1.437 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.657898e-02 | 1.437 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.851034e-02 | 1.545 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.843331e-02 | 1.415 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.337763e-02 | 1.631 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.927668e-02 | 1.533 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.927668e-02 | 1.533 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.249404e-02 | 1.488 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.463647e-02 | 1.460 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.463647e-02 | 1.460 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.233853e-02 | 1.490 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.371385e-02 | 1.625 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.526435e-02 | 1.597 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.360591e-02 | 1.474 |
| R-HSA-418990 | Adherens junctions interactions | 2.472490e-02 | 1.607 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.828379e-02 | 1.417 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.432416e-02 | 1.464 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.945841e-02 | 1.404 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.824379e-02 | 1.549 |
| R-HSA-1500931 | Cell-Cell communication | 3.876584e-02 | 1.412 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.360591e-02 | 1.474 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.724593e-02 | 1.565 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.666989e-02 | 1.574 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.473741e-02 | 1.459 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.626166e-02 | 1.441 |
| R-HSA-2559583 | Cellular Senescence | 3.938944e-02 | 1.405 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.040025e-02 | 1.517 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.666989e-02 | 1.574 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.309357e-02 | 1.637 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.314165e-02 | 1.636 |
| R-HSA-162906 | HIV Infection | 2.890203e-02 | 1.539 |
| R-HSA-109581 | Apoptosis | 2.735555e-02 | 1.563 |
| R-HSA-5218859 | Regulated Necrosis | 3.473741e-02 | 1.459 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.851034e-02 | 1.545 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.068707e-02 | 1.391 |
| R-HSA-421270 | Cell-cell junction organization | 4.223504e-02 | 1.374 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.271963e-02 | 1.369 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.271963e-02 | 1.369 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.271963e-02 | 1.369 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.271963e-02 | 1.369 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.271963e-02 | 1.369 |
| R-HSA-380287 | Centrosome maturation | 4.320195e-02 | 1.364 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.320195e-02 | 1.364 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.448801e-02 | 1.352 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.492676e-02 | 1.347 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 4.551410e-02 | 1.342 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 4.551410e-02 | 1.342 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 4.551410e-02 | 1.342 |
| R-HSA-5617833 | Cilium Assembly | 4.683927e-02 | 1.329 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.717526e-02 | 1.326 |
| R-HSA-68911 | G2 Phase | 6.313812e-02 | 1.200 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.179260e-02 | 1.286 |
| R-HSA-390522 | Striated Muscle Contraction | 5.415958e-02 | 1.266 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.900565e-02 | 1.229 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.289518e-02 | 1.201 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.656423e-02 | 1.247 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.900565e-02 | 1.229 |
| R-HSA-68877 | Mitotic Prometaphase | 4.922698e-02 | 1.308 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 6.313812e-02 | 1.200 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 6.313812e-02 | 1.200 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.179260e-02 | 1.286 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.259909e-02 | 1.279 |
| R-HSA-9659379 | Sensory processing of sound | 4.845954e-02 | 1.315 |
| R-HSA-1538133 | G0 and Early G1 | 4.946419e-02 | 1.306 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 6.313812e-02 | 1.200 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.545075e-02 | 1.256 |
| R-HSA-9833482 | PKR-mediated signaling | 4.982085e-02 | 1.303 |
| R-HSA-196757 | Metabolism of folate and pterines | 6.399533e-02 | 1.194 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.137073e-02 | 1.212 |
| R-HSA-73884 | Base Excision Repair | 6.599653e-02 | 1.180 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 6.654186e-02 | 1.177 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.182853e-02 | 1.144 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.182853e-02 | 1.144 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 7.182853e-02 | 1.144 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 7.182853e-02 | 1.144 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.182853e-02 | 1.144 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 7.182853e-02 | 1.144 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 7.182853e-02 | 1.144 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.240546e-02 | 1.140 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 7.437819e-02 | 1.129 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 7.437819e-02 | 1.129 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 7.437819e-02 | 1.129 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.043886e-02 | 1.095 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 8.043886e-02 | 1.095 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.057967e-01 | 0.976 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.140939e-01 | 0.943 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.385297e-01 | 0.858 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.465252e-01 | 0.834 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.465252e-01 | 0.834 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.544470e-01 | 0.811 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.700721e-01 | 0.769 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.777768e-01 | 0.750 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.854104e-01 | 0.732 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.004671e-01 | 0.698 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.004671e-01 | 0.698 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 7.975823e-02 | 1.098 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.078914e-01 | 0.682 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.078914e-01 | 0.682 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.078914e-01 | 0.682 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.078914e-01 | 0.682 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.152473e-01 | 0.667 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 9.370826e-02 | 1.028 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.023914e-01 | 0.990 |
| R-HSA-72649 | Translation initiation complex formation | 1.142948e-01 | 0.942 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.203742e-01 | 0.919 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.648580e-01 | 0.783 |
| R-HSA-72172 | mRNA Splicing | 1.576158e-01 | 0.802 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.327630e-01 | 0.877 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.388020e-01 | 0.858 |
| R-HSA-73893 | DNA Damage Bypass | 9.947259e-02 | 1.002 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.265319e-01 | 0.898 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.140939e-01 | 0.943 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.622957e-01 | 0.790 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.004671e-01 | 0.698 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.714347e-01 | 0.766 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 9.086413e-02 | 1.042 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.304597e-01 | 0.885 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 8.804633e-02 | 1.055 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.482524e-01 | 0.829 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.025187e-01 | 0.989 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 8.525558e-02 | 1.069 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.700721e-01 | 0.769 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 8.043886e-02 | 1.095 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.304597e-01 | 0.885 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.385297e-01 | 0.858 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.465252e-01 | 0.834 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.622957e-01 | 0.790 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.777768e-01 | 0.750 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.929736e-01 | 0.715 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.369102e-01 | 0.625 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.053337e-01 | 0.977 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.082988e-01 | 0.965 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.615871e-01 | 0.792 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.929736e-01 | 0.715 |
| R-HSA-448706 | Interleukin-1 processing | 1.057967e-01 | 0.976 |
| R-HSA-8963888 | Chylomicron assembly | 1.223147e-01 | 0.913 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.297560e-01 | 0.639 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.053337e-01 | 0.977 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.259868e-01 | 0.900 |
| R-HSA-8964041 | LDL remodeling | 8.896984e-02 | 1.051 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.622957e-01 | 0.790 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.777768e-01 | 0.750 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.004671e-01 | 0.698 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.078914e-01 | 0.682 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.152473e-01 | 0.667 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.304597e-01 | 0.885 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.390627e-01 | 0.857 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.486310e-01 | 0.828 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.981346e-01 | 0.703 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.057967e-01 | 0.976 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.265319e-01 | 0.898 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.929736e-01 | 0.715 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.648580e-01 | 0.783 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 8.043886e-02 | 1.095 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.057967e-01 | 0.976 |
| R-HSA-425381 | Bicarbonate transporters | 1.223147e-01 | 0.913 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.385297e-01 | 0.858 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.385297e-01 | 0.858 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.544470e-01 | 0.811 |
| R-HSA-8953854 | Metabolism of RNA | 1.759796e-01 | 0.755 |
| R-HSA-8876725 | Protein methylation | 1.622957e-01 | 0.790 |
| R-HSA-5696398 | Nucleotide Excision Repair | 9.688499e-02 | 1.014 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.929736e-01 | 0.715 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2.152473e-01 | 0.667 |
| R-HSA-8866423 | VLDL assembly | 8.043886e-02 | 1.095 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.057967e-01 | 0.976 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.223147e-01 | 0.913 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.465252e-01 | 0.834 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.544470e-01 | 0.811 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.078914e-01 | 0.682 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.369102e-01 | 0.625 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.369102e-01 | 0.625 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.053337e-01 | 0.977 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.648580e-01 | 0.783 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.929736e-01 | 0.715 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.082773e-01 | 0.681 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.321326e-01 | 0.634 |
| R-HSA-71262 | Carnitine synthesis | 1.700721e-01 | 0.769 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.854104e-01 | 0.732 |
| R-HSA-9755088 | Ribavirin ADME | 2.225353e-01 | 0.653 |
| R-HSA-202424 | Downstream TCR signaling | 2.355565e-01 | 0.628 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.342489e-01 | 0.630 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.385297e-01 | 0.858 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.297560e-01 | 0.639 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.203742e-01 | 0.919 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.544470e-01 | 0.811 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.385297e-01 | 0.858 |
| R-HSA-416700 | Other semaphorin interactions | 1.622957e-01 | 0.790 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.119696e-01 | 0.674 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.622957e-01 | 0.790 |
| R-HSA-2028269 | Signaling by Hippo | 1.854104e-01 | 0.732 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.975125e-01 | 0.704 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 9.947259e-02 | 1.002 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 9.947259e-02 | 1.002 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.422369e-01 | 0.847 |
| R-HSA-9020933 | Interleukin-23 signaling | 9.742220e-02 | 1.011 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.681407e-01 | 0.774 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.385297e-01 | 0.858 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.218818e-01 | 0.654 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.297560e-01 | 0.639 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.929736e-01 | 0.715 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.297560e-01 | 0.639 |
| R-HSA-6783783 | Interleukin-10 signaling | 1.914080e-01 | 0.718 |
| R-HSA-73942 | DNA Damage Reversal | 1.622957e-01 | 0.790 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.044252e-01 | 0.981 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.813792e-01 | 0.741 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.700721e-01 | 0.769 |
| R-HSA-449836 | Other interleukin signaling | 2.004671e-01 | 0.698 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.583284e-01 | 0.800 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.213979e-01 | 0.655 |
| R-HSA-449147 | Signaling by Interleukins | 1.503223e-01 | 0.823 |
| R-HSA-9612973 | Autophagy | 2.214951e-01 | 0.655 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.223147e-01 | 0.913 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.234436e-01 | 0.909 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.881077e-01 | 0.726 |
| R-HSA-162587 | HIV Life Cycle | 8.195938e-02 | 1.086 |
| R-HSA-9758941 | Gastrulation | 2.046405e-01 | 0.689 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.486310e-01 | 0.828 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.152473e-01 | 0.667 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.086827e-01 | 0.964 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 1.265319e-01 | 0.898 |
| R-HSA-429947 | Deadenylation of mRNA | 2.439983e-01 | 0.613 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.439983e-01 | 0.613 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.439983e-01 | 0.613 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.439983e-01 | 0.613 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.439983e-01 | 0.613 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.439983e-01 | 0.613 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.439983e-01 | 0.613 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.458445e-01 | 0.609 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.510210e-01 | 0.600 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.510210e-01 | 0.600 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.510210e-01 | 0.600 |
| R-HSA-1474290 | Collagen formation | 2.527132e-01 | 0.597 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.579790e-01 | 0.588 |
| R-HSA-525793 | Myogenesis | 2.579790e-01 | 0.588 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.579790e-01 | 0.588 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.579790e-01 | 0.588 |
| R-HSA-3295583 | TRP channels | 2.579790e-01 | 0.588 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.630249e-01 | 0.580 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 2.648727e-01 | 0.577 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.648727e-01 | 0.577 |
| R-HSA-264876 | Insulin processing | 2.648727e-01 | 0.577 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.648727e-01 | 0.577 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.699015e-01 | 0.569 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.717027e-01 | 0.566 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.784698e-01 | 0.555 |
| R-HSA-72086 | mRNA Capping | 2.784698e-01 | 0.555 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.784698e-01 | 0.555 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.802137e-01 | 0.553 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.851744e-01 | 0.545 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.851744e-01 | 0.545 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.851744e-01 | 0.545 |
| R-HSA-6798695 | Neutrophil degranulation | 2.875662e-01 | 0.541 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.905158e-01 | 0.537 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.918171e-01 | 0.535 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.918171e-01 | 0.535 |
| R-HSA-9833110 | RSV-host interactions | 2.939463e-01 | 0.532 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.983984e-01 | 0.525 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.008006e-01 | 0.522 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.049191e-01 | 0.516 |
| R-HSA-9930044 | Nuclear RNA decay | 3.049191e-01 | 0.516 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.049191e-01 | 0.516 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.049191e-01 | 0.516 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.076441e-01 | 0.512 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.076441e-01 | 0.512 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.076441e-01 | 0.512 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.076441e-01 | 0.512 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.113795e-01 | 0.507 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.113795e-01 | 0.507 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.113795e-01 | 0.507 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.113795e-01 | 0.507 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.113795e-01 | 0.507 |
| R-HSA-202403 | TCR signaling | 3.144750e-01 | 0.502 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.177802e-01 | 0.498 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.177802e-01 | 0.498 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.177802e-01 | 0.498 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.177802e-01 | 0.498 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.177802e-01 | 0.498 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.177802e-01 | 0.498 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.177802e-01 | 0.498 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.177802e-01 | 0.498 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.177802e-01 | 0.498 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.241219e-01 | 0.489 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.241219e-01 | 0.489 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.241219e-01 | 0.489 |
| R-HSA-169911 | Regulation of Apoptosis | 3.241219e-01 | 0.489 |
| R-HSA-913531 | Interferon Signaling | 3.244276e-01 | 0.489 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.280914e-01 | 0.484 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.304050e-01 | 0.481 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.304050e-01 | 0.481 |
| R-HSA-3371511 | HSF1 activation | 3.304050e-01 | 0.481 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.304050e-01 | 0.481 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.304050e-01 | 0.481 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.314847e-01 | 0.480 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.366301e-01 | 0.473 |
| R-HSA-4641258 | Degradation of DVL | 3.366301e-01 | 0.473 |
| R-HSA-4641257 | Degradation of AXIN | 3.366301e-01 | 0.473 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.366301e-01 | 0.473 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.416358e-01 | 0.466 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.416358e-01 | 0.466 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.427977e-01 | 0.465 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.483769e-01 | 0.458 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.489083e-01 | 0.457 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.489083e-01 | 0.457 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.489083e-01 | 0.457 |
| R-HSA-69541 | Stabilization of p53 | 3.489083e-01 | 0.457 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.489083e-01 | 0.457 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.549625e-01 | 0.450 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.549625e-01 | 0.450 |
| R-HSA-5260271 | Diseases of Immune System | 3.549625e-01 | 0.450 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.549625e-01 | 0.450 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.549625e-01 | 0.450 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.549625e-01 | 0.450 |
| R-HSA-68875 | Mitotic Prophase | 3.550953e-01 | 0.450 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.609607e-01 | 0.443 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.609607e-01 | 0.443 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.609607e-01 | 0.443 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.609607e-01 | 0.443 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.651270e-01 | 0.438 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.669036e-01 | 0.435 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.669036e-01 | 0.435 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.669036e-01 | 0.435 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.669036e-01 | 0.435 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.669036e-01 | 0.435 |
| R-HSA-397014 | Muscle contraction | 3.671460e-01 | 0.435 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.684580e-01 | 0.434 |
| R-HSA-165159 | MTOR signalling | 3.727915e-01 | 0.429 |
| R-HSA-69206 | G1/S Transition | 3.750996e-01 | 0.426 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.786251e-01 | 0.422 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.844047e-01 | 0.415 |
| R-HSA-9907900 | Proteasome assembly | 3.844047e-01 | 0.415 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.844047e-01 | 0.415 |
| R-HSA-5683826 | Surfactant metabolism | 3.844047e-01 | 0.415 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.901310e-01 | 0.409 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.901310e-01 | 0.409 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.901310e-01 | 0.409 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.901310e-01 | 0.409 |
| R-HSA-9824272 | Somitogenesis | 3.901310e-01 | 0.409 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.901310e-01 | 0.409 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.958043e-01 | 0.403 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.958043e-01 | 0.403 |
| R-HSA-9675135 | Diseases of DNA repair | 3.958043e-01 | 0.403 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.958043e-01 | 0.403 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.958043e-01 | 0.403 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.958043e-01 | 0.403 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.014252e-01 | 0.396 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.069942e-01 | 0.390 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.069942e-01 | 0.390 |
| R-HSA-72766 | Translation | 4.090915e-01 | 0.388 |
| R-HSA-9748787 | Azathioprine ADME | 4.179782e-01 | 0.379 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.207364e-01 | 0.376 |
| R-HSA-912446 | Meiotic recombination | 4.233941e-01 | 0.373 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 4.233941e-01 | 0.373 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.239333e-01 | 0.373 |
| R-HSA-72187 | mRNA 3'-end processing | 4.287600e-01 | 0.368 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.287600e-01 | 0.368 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.287600e-01 | 0.368 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.287600e-01 | 0.368 |
| R-HSA-1632852 | Macroautophagy | 4.334692e-01 | 0.363 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.340763e-01 | 0.362 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.340763e-01 | 0.362 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.340763e-01 | 0.362 |
| R-HSA-156588 | Glucuronidation | 4.393435e-01 | 0.357 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.445619e-01 | 0.352 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.460526e-01 | 0.351 |
| R-HSA-9679506 | SARS-CoV Infections | 4.490365e-01 | 0.348 |
| R-HSA-75893 | TNF signaling | 4.497321e-01 | 0.347 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.497321e-01 | 0.347 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.497321e-01 | 0.347 |
| R-HSA-177929 | Signaling by EGFR | 4.497321e-01 | 0.347 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.548545e-01 | 0.342 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.649576e-01 | 0.333 |
| R-HSA-983189 | Kinesins | 4.699392e-01 | 0.328 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.699392e-01 | 0.328 |
| R-HSA-351202 | Metabolism of polyamines | 4.699392e-01 | 0.328 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.707470e-01 | 0.327 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.707470e-01 | 0.327 |
| R-HSA-5688426 | Deubiquitination | 4.731211e-01 | 0.325 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.748747e-01 | 0.323 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.748747e-01 | 0.323 |
| R-HSA-450294 | MAP kinase activation | 4.748747e-01 | 0.323 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.748747e-01 | 0.323 |
| R-HSA-8848021 | Signaling by PTK6 | 4.846092e-01 | 0.315 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.846092e-01 | 0.315 |
| R-HSA-373755 | Semaphorin interactions | 4.846092e-01 | 0.315 |
| R-HSA-9610379 | HCMV Late Events | 4.858464e-01 | 0.314 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.888344e-01 | 0.311 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.894090e-01 | 0.310 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.947781e-01 | 0.306 |
| R-HSA-9824446 | Viral Infection Pathways | 5.062149e-01 | 0.296 |
| R-HSA-167172 | Transcription of the HIV genome | 5.081682e-01 | 0.294 |
| R-HSA-448424 | Interleukin-17 signaling | 5.172895e-01 | 0.286 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.172895e-01 | 0.286 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.172895e-01 | 0.286 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.217869e-01 | 0.283 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.217869e-01 | 0.283 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.273821e-01 | 0.278 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.295120e-01 | 0.276 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.306572e-01 | 0.275 |
| R-HSA-5663205 | Infectious disease | 5.333628e-01 | 0.273 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.350309e-01 | 0.272 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 5.350309e-01 | 0.272 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.350309e-01 | 0.272 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.350309e-01 | 0.272 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.351430e-01 | 0.272 |
| R-HSA-1280218 | Adaptive Immune System | 5.385022e-01 | 0.269 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.407282e-01 | 0.267 |
| R-HSA-5689603 | UCH proteinases | 5.436571e-01 | 0.265 |
| R-HSA-5619084 | ABC transporter disorders | 5.521244e-01 | 0.258 |
| R-HSA-4086400 | PCP/CE pathway | 5.521244e-01 | 0.258 |
| R-HSA-216083 | Integrin cell surface interactions | 5.521244e-01 | 0.258 |
| R-HSA-6806834 | Signaling by MET | 5.604356e-01 | 0.251 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.640292e-01 | 0.249 |
| R-HSA-162582 | Signal Transduction | 5.662256e-01 | 0.247 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.685936e-01 | 0.245 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.766011e-01 | 0.239 |
| R-HSA-983712 | Ion channel transport | 5.785218e-01 | 0.238 |
| R-HSA-1500620 | Meiosis | 5.805494e-01 | 0.236 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.805494e-01 | 0.236 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.805494e-01 | 0.236 |
| R-HSA-1643685 | Disease | 5.831231e-01 | 0.234 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.844610e-01 | 0.233 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.863211e-01 | 0.232 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.883365e-01 | 0.230 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.921760e-01 | 0.228 |
| R-HSA-156902 | Peptide chain elongation | 5.959799e-01 | 0.225 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.959799e-01 | 0.225 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.034824e-01 | 0.219 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.108465e-01 | 0.214 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.140088e-01 | 0.212 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.140088e-01 | 0.212 |
| R-HSA-391251 | Protein folding | 6.144774e-01 | 0.211 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.144774e-01 | 0.211 |
| R-HSA-168256 | Immune System | 6.200874e-01 | 0.208 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.251695e-01 | 0.204 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.286677e-01 | 0.202 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.286677e-01 | 0.202 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.321334e-01 | 0.199 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.321334e-01 | 0.199 |
| R-HSA-1296071 | Potassium Channels | 6.321334e-01 | 0.199 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.355670e-01 | 0.197 |
| R-HSA-2262752 | Cellular responses to stress | 6.365511e-01 | 0.196 |
| R-HSA-1474244 | Extracellular matrix organization | 6.372712e-01 | 0.196 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.389687e-01 | 0.195 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.389687e-01 | 0.195 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.389687e-01 | 0.195 |
| R-HSA-422356 | Regulation of insulin secretion | 6.389687e-01 | 0.195 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.456779e-01 | 0.190 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.456779e-01 | 0.190 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.578799e-01 | 0.182 |
| R-HSA-8951664 | Neddylation | 6.584781e-01 | 0.181 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.587269e-01 | 0.181 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.650713e-01 | 0.177 |
| R-HSA-1266738 | Developmental Biology | 6.668237e-01 | 0.176 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.705540e-01 | 0.174 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.712985e-01 | 0.173 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.712985e-01 | 0.173 |
| R-HSA-211000 | Gene Silencing by RNA | 6.712985e-01 | 0.173 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.743688e-01 | 0.171 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.774107e-01 | 0.169 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.780804e-01 | 0.169 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.804243e-01 | 0.167 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.804243e-01 | 0.167 |
| R-HSA-6803157 | Antimicrobial peptides | 6.834099e-01 | 0.165 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.863679e-01 | 0.163 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.863679e-01 | 0.163 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.892983e-01 | 0.162 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 6.967639e-01 | 0.157 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.979276e-01 | 0.156 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.007507e-01 | 0.154 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.063187e-01 | 0.151 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.117837e-01 | 0.148 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.117837e-01 | 0.148 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.117837e-01 | 0.148 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.126160e-01 | 0.147 |
| R-HSA-3371556 | Cellular response to heat stress | 7.171477e-01 | 0.144 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.171477e-01 | 0.144 |
| R-HSA-9609646 | HCMV Infection | 7.183806e-01 | 0.144 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.197924e-01 | 0.143 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.197924e-01 | 0.143 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.224126e-01 | 0.141 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.301278e-01 | 0.137 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.301278e-01 | 0.137 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.301278e-01 | 0.137 |
| R-HSA-194138 | Signaling by VEGF | 7.301278e-01 | 0.137 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.394332e-01 | 0.131 |
| R-HSA-1474165 | Reproduction | 7.449250e-01 | 0.128 |
| R-HSA-9843745 | Adipogenesis | 7.473117e-01 | 0.126 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.496761e-01 | 0.125 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.496761e-01 | 0.125 |
| R-HSA-9909396 | Circadian clock | 7.496761e-01 | 0.125 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.497397e-01 | 0.125 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.509688e-01 | 0.124 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.611726e-01 | 0.119 |
| R-HSA-163685 | Integration of energy metabolism | 7.611726e-01 | 0.119 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.656229e-01 | 0.116 |
| R-HSA-6807070 | PTEN Regulation | 7.678171e-01 | 0.115 |
| R-HSA-9664407 | Parasite infection | 7.699909e-01 | 0.114 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.699909e-01 | 0.114 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.699909e-01 | 0.114 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.721445e-01 | 0.112 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.724559e-01 | 0.112 |
| R-HSA-9658195 | Leishmania infection | 7.724559e-01 | 0.112 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.763917e-01 | 0.110 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.784857e-01 | 0.109 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.848664e-01 | 0.105 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.886672e-01 | 0.103 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.926084e-01 | 0.101 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.945515e-01 | 0.100 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.952374e-01 | 0.100 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.002730e-01 | 0.097 |
| R-HSA-73887 | Death Receptor Signaling | 8.002730e-01 | 0.097 |
| R-HSA-1989781 | PPARA activates gene expression | 8.021448e-01 | 0.096 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.058363e-01 | 0.094 |
| R-HSA-168249 | Innate Immune System | 8.159261e-01 | 0.088 |
| R-HSA-5619102 | SLC transporter disorders | 8.232920e-01 | 0.084 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.298296e-01 | 0.081 |
| R-HSA-382551 | Transport of small molecules | 8.305750e-01 | 0.081 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.330076e-01 | 0.079 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.337145e-01 | 0.079 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.361268e-01 | 0.078 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.494618e-01 | 0.071 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.563984e-01 | 0.067 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.583599e-01 | 0.066 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.604070e-01 | 0.065 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.717779e-01 | 0.060 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.717779e-01 | 0.060 |
| R-HSA-199991 | Membrane Trafficking | 8.736919e-01 | 0.059 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.751151e-01 | 0.058 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.753599e-01 | 0.058 |
| R-HSA-9748784 | Drug ADME | 8.928499e-01 | 0.049 |
| R-HSA-422475 | Axon guidance | 9.006142e-01 | 0.045 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.006575e-01 | 0.045 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.025194e-01 | 0.045 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.034374e-01 | 0.044 |
| R-HSA-72312 | rRNA processing | 9.061399e-01 | 0.043 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.078997e-01 | 0.042 |
| R-HSA-157118 | Signaling by NOTCH | 9.129849e-01 | 0.040 |
| R-HSA-4839726 | Chromatin organization | 9.200944e-01 | 0.036 |
| R-HSA-9675108 | Nervous system development | 9.224878e-01 | 0.035 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.252224e-01 | 0.034 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.328624e-01 | 0.030 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.373470e-01 | 0.028 |
| R-HSA-112316 | Neuronal System | 9.441777e-01 | 0.025 |
| R-HSA-109582 | Hemostasis | 9.451774e-01 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 9.483526e-01 | 0.023 |
| R-HSA-195721 | Signaling by WNT | 9.498040e-01 | 0.022 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.530619e-01 | 0.021 |
| R-HSA-597592 | Post-translational protein modification | 9.572046e-01 | 0.019 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.604257e-01 | 0.018 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.604257e-01 | 0.018 |
| R-HSA-211859 | Biological oxidations | 9.639642e-01 | 0.016 |
| R-HSA-74160 | Gene expression (Transcription) | 9.660958e-01 | 0.015 |
| R-HSA-392499 | Metabolism of proteins | 9.735765e-01 | 0.012 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.800878e-01 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 9.824162e-01 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.834238e-01 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 9.854808e-01 | 0.006 |
| R-HSA-212436 | Generic Transcription Pathway | 9.928656e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.969499e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.994968e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.995280e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.997774e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999936e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.839 | 0.154 | 2 | 0.872 |
CDC7 |
0.832 | 0.116 | 1 | 0.874 |
DSTYK |
0.831 | 0.145 | 2 | 0.883 |
BMPR1B |
0.823 | 0.224 | 1 | 0.849 |
MOS |
0.821 | 0.078 | 1 | 0.865 |
PIM3 |
0.821 | 0.024 | -3 | 0.718 |
CLK3 |
0.821 | 0.102 | 1 | 0.784 |
IKKB |
0.820 | -0.022 | -2 | 0.753 |
RAF1 |
0.820 | -0.002 | 1 | 0.800 |
GCN2 |
0.819 | -0.049 | 2 | 0.788 |
PRPK |
0.818 | -0.124 | -1 | 0.827 |
CAMK1B |
0.817 | 0.005 | -3 | 0.778 |
ULK2 |
0.817 | -0.059 | 2 | 0.770 |
BMPR2 |
0.816 | 0.019 | -2 | 0.881 |
NEK7 |
0.816 | 0.019 | -3 | 0.744 |
GRK6 |
0.815 | 0.083 | 1 | 0.825 |
FAM20C |
0.814 | 0.084 | 2 | 0.604 |
RSK2 |
0.814 | 0.024 | -3 | 0.669 |
IKKA |
0.814 | 0.085 | -2 | 0.731 |
IKKE |
0.814 | -0.032 | 1 | 0.681 |
CAMK2G |
0.813 | -0.051 | 2 | 0.789 |
TBK1 |
0.813 | -0.057 | 1 | 0.677 |
TGFBR2 |
0.813 | 0.032 | -2 | 0.821 |
NEK6 |
0.812 | 0.023 | -2 | 0.879 |
NDR2 |
0.812 | -0.028 | -3 | 0.716 |
ATR |
0.812 | -0.016 | 1 | 0.780 |
NLK |
0.811 | -0.020 | 1 | 0.750 |
ACVR2B |
0.811 | 0.195 | -2 | 0.834 |
BMPR1A |
0.811 | 0.212 | 1 | 0.837 |
MLK1 |
0.810 | -0.026 | 2 | 0.803 |
ERK5 |
0.810 | 0.042 | 1 | 0.775 |
ACVR2A |
0.810 | 0.168 | -2 | 0.826 |
NDR1 |
0.810 | -0.020 | -3 | 0.724 |
MTOR |
0.809 | -0.118 | 1 | 0.699 |
PDHK4 |
0.809 | -0.259 | 1 | 0.792 |
PRKD2 |
0.809 | 0.026 | -3 | 0.674 |
CHAK2 |
0.809 | 0.027 | -1 | 0.827 |
PIM1 |
0.808 | 0.021 | -3 | 0.683 |
ULK1 |
0.808 | -0.091 | -3 | 0.749 |
PKN3 |
0.807 | -0.042 | -3 | 0.718 |
PLK1 |
0.807 | 0.087 | -2 | 0.859 |
GRK5 |
0.807 | -0.082 | -3 | 0.763 |
RIPK3 |
0.807 | -0.061 | 3 | 0.782 |
NIK |
0.807 | -0.059 | -3 | 0.792 |
CAMLCK |
0.807 | -0.018 | -2 | 0.847 |
PRKD1 |
0.806 | -0.026 | -3 | 0.689 |
GRK1 |
0.806 | 0.034 | -2 | 0.730 |
P70S6KB |
0.806 | -0.002 | -3 | 0.704 |
SKMLCK |
0.806 | -0.006 | -2 | 0.832 |
CDKL1 |
0.806 | -0.045 | -3 | 0.692 |
MST4 |
0.806 | -0.026 | 2 | 0.818 |
PDHK1 |
0.806 | -0.201 | 1 | 0.786 |
TGFBR1 |
0.805 | 0.091 | -2 | 0.781 |
DAPK2 |
0.805 | -0.021 | -3 | 0.764 |
TSSK2 |
0.804 | -0.009 | -5 | 0.678 |
PKCD |
0.804 | 0.016 | 2 | 0.767 |
P90RSK |
0.804 | -0.036 | -3 | 0.666 |
RSK3 |
0.804 | -0.019 | -3 | 0.668 |
MARK4 |
0.804 | -0.055 | 4 | 0.734 |
PKN2 |
0.804 | -0.029 | -3 | 0.741 |
NUAK2 |
0.803 | -0.046 | -3 | 0.750 |
ALK2 |
0.803 | 0.124 | -2 | 0.793 |
NEK9 |
0.803 | -0.048 | 2 | 0.817 |
GRK4 |
0.802 | -0.032 | -2 | 0.795 |
SRPK1 |
0.802 | -0.009 | -3 | 0.643 |
ALK4 |
0.802 | 0.038 | -2 | 0.808 |
HUNK |
0.802 | -0.114 | 2 | 0.811 |
WNK1 |
0.801 | -0.071 | -2 | 0.839 |
ATM |
0.801 | 0.007 | 1 | 0.730 |
MAPKAPK3 |
0.801 | -0.042 | -3 | 0.662 |
LATS2 |
0.801 | -0.032 | -5 | 0.679 |
PLK3 |
0.800 | 0.069 | 2 | 0.780 |
CDKL5 |
0.800 | -0.032 | -3 | 0.675 |
PKACG |
0.800 | -0.003 | -2 | 0.776 |
ANKRD3 |
0.800 | -0.076 | 1 | 0.798 |
AURC |
0.800 | 0.032 | -2 | 0.678 |
KIS |
0.799 | -0.017 | 1 | 0.618 |
PKR |
0.799 | 0.040 | 1 | 0.793 |
MAPKAPK2 |
0.799 | -0.020 | -3 | 0.624 |
LATS1 |
0.799 | 0.047 | -3 | 0.718 |
MLK4 |
0.799 | 0.036 | 2 | 0.727 |
DLK |
0.799 | -0.093 | 1 | 0.790 |
PAK6 |
0.799 | 0.071 | -2 | 0.712 |
CAMK2D |
0.798 | -0.086 | -3 | 0.729 |
TTBK2 |
0.798 | -0.090 | 2 | 0.713 |
RSK4 |
0.798 | 0.021 | -3 | 0.631 |
TSSK1 |
0.798 | -0.014 | -3 | 0.761 |
AMPKA1 |
0.798 | -0.068 | -3 | 0.749 |
MEK1 |
0.797 | -0.023 | 2 | 0.844 |
WNK3 |
0.797 | -0.181 | 1 | 0.751 |
CAMK2B |
0.797 | -0.016 | 2 | 0.776 |
PRKD3 |
0.797 | -0.013 | -3 | 0.662 |
GRK7 |
0.796 | 0.089 | 1 | 0.729 |
BCKDK |
0.796 | -0.178 | -1 | 0.777 |
MLK3 |
0.796 | -0.024 | 2 | 0.733 |
MLK2 |
0.795 | -0.101 | 2 | 0.816 |
CLK1 |
0.795 | 0.030 | -3 | 0.678 |
NIM1 |
0.794 | -0.102 | 3 | 0.819 |
PAK1 |
0.794 | -0.034 | -2 | 0.763 |
PKACB |
0.794 | 0.032 | -2 | 0.713 |
ICK |
0.794 | -0.068 | -3 | 0.720 |
HIPK4 |
0.793 | -0.066 | 1 | 0.724 |
CAMK4 |
0.793 | -0.083 | -3 | 0.735 |
AURB |
0.793 | 0.012 | -2 | 0.675 |
MYLK4 |
0.793 | -0.013 | -2 | 0.781 |
SRPK2 |
0.793 | -0.022 | -3 | 0.575 |
CLK4 |
0.793 | 0.000 | -3 | 0.685 |
YSK4 |
0.792 | -0.061 | 1 | 0.722 |
AMPKA2 |
0.792 | -0.060 | -3 | 0.719 |
PAK3 |
0.791 | -0.065 | -2 | 0.776 |
SRPK3 |
0.791 | -0.024 | -3 | 0.624 |
RIPK1 |
0.791 | -0.183 | 1 | 0.752 |
IRE1 |
0.791 | -0.110 | 1 | 0.739 |
BRAF |
0.791 | 0.019 | -4 | 0.725 |
QSK |
0.791 | -0.044 | 4 | 0.716 |
PRKX |
0.791 | 0.063 | -3 | 0.588 |
TLK2 |
0.790 | -0.009 | 1 | 0.745 |
MSK2 |
0.790 | -0.074 | -3 | 0.622 |
CDK8 |
0.790 | -0.046 | 1 | 0.589 |
PKG2 |
0.790 | 0.027 | -2 | 0.724 |
MSK1 |
0.790 | -0.022 | -3 | 0.629 |
AKT2 |
0.790 | 0.004 | -3 | 0.606 |
JNK2 |
0.789 | 0.029 | 1 | 0.538 |
MASTL |
0.789 | -0.322 | -2 | 0.803 |
PERK |
0.789 | -0.014 | -2 | 0.864 |
NUAK1 |
0.789 | -0.061 | -3 | 0.709 |
SMG1 |
0.789 | -0.019 | 1 | 0.727 |
CAMK2A |
0.789 | -0.044 | 2 | 0.786 |
NEK2 |
0.789 | -0.081 | 2 | 0.798 |
PKCB |
0.789 | -0.035 | 2 | 0.728 |
AURA |
0.789 | 0.006 | -2 | 0.630 |
MNK2 |
0.789 | -0.026 | -2 | 0.801 |
MELK |
0.789 | -0.066 | -3 | 0.705 |
DRAK1 |
0.789 | -0.019 | 1 | 0.724 |
PIM2 |
0.789 | -0.012 | -3 | 0.655 |
MARK2 |
0.788 | -0.036 | 4 | 0.638 |
JNK3 |
0.788 | 0.011 | 1 | 0.571 |
CLK2 |
0.788 | 0.046 | -3 | 0.663 |
CHAK1 |
0.788 | -0.091 | 2 | 0.770 |
CHK1 |
0.788 | -0.046 | -3 | 0.724 |
SIK |
0.788 | -0.052 | -3 | 0.680 |
QIK |
0.787 | -0.124 | -3 | 0.734 |
MARK3 |
0.787 | -0.036 | 4 | 0.672 |
IRE2 |
0.787 | -0.089 | 2 | 0.701 |
GRK2 |
0.786 | -0.026 | -2 | 0.673 |
VRK2 |
0.786 | -0.193 | 1 | 0.815 |
CK2A2 |
0.786 | 0.124 | 1 | 0.760 |
BRSK1 |
0.786 | -0.080 | -3 | 0.697 |
PKCG |
0.785 | -0.069 | 2 | 0.725 |
MNK1 |
0.785 | -0.018 | -2 | 0.819 |
SGK3 |
0.785 | -0.007 | -3 | 0.646 |
DYRK2 |
0.784 | -0.045 | 1 | 0.638 |
CDK1 |
0.784 | -0.007 | 1 | 0.559 |
PINK1 |
0.784 | -0.090 | 1 | 0.741 |
MEKK3 |
0.784 | -0.092 | 1 | 0.752 |
PAK2 |
0.784 | -0.084 | -2 | 0.750 |
PLK2 |
0.784 | 0.135 | -3 | 0.833 |
PKCA |
0.784 | -0.053 | 2 | 0.712 |
HRI |
0.783 | -0.087 | -2 | 0.881 |
TLK1 |
0.783 | -0.044 | -2 | 0.830 |
CDK19 |
0.783 | -0.050 | 1 | 0.551 |
PKCH |
0.783 | -0.071 | 2 | 0.703 |
MARK1 |
0.783 | -0.063 | 4 | 0.688 |
CDK5 |
0.783 | -0.011 | 1 | 0.611 |
MEKK2 |
0.782 | -0.028 | 2 | 0.792 |
PLK4 |
0.782 | -0.067 | 2 | 0.633 |
CDK2 |
0.782 | -0.022 | 1 | 0.636 |
PKACA |
0.781 | 0.024 | -2 | 0.677 |
P38A |
0.781 | -0.021 | 1 | 0.632 |
DNAPK |
0.781 | -0.044 | 1 | 0.634 |
PHKG1 |
0.780 | -0.117 | -3 | 0.724 |
GAK |
0.780 | 0.047 | 1 | 0.782 |
SNRK |
0.780 | -0.173 | 2 | 0.689 |
CAMK1G |
0.780 | -0.082 | -3 | 0.682 |
BRSK2 |
0.779 | -0.122 | -3 | 0.721 |
SSTK |
0.779 | -0.026 | 4 | 0.701 |
PKCZ |
0.779 | -0.092 | 2 | 0.771 |
CDK7 |
0.779 | -0.080 | 1 | 0.595 |
SMMLCK |
0.779 | -0.046 | -3 | 0.722 |
DCAMKL1 |
0.779 | -0.045 | -3 | 0.700 |
ZAK |
0.778 | -0.110 | 1 | 0.736 |
PRP4 |
0.778 | -0.036 | -3 | 0.658 |
MEK5 |
0.778 | -0.202 | 2 | 0.822 |
MEKK1 |
0.778 | -0.109 | 1 | 0.756 |
P38B |
0.778 | -0.016 | 1 | 0.573 |
CDK18 |
0.777 | -0.024 | 1 | 0.522 |
P70S6K |
0.777 | -0.058 | -3 | 0.609 |
NEK5 |
0.777 | -0.079 | 1 | 0.766 |
AKT1 |
0.777 | -0.003 | -3 | 0.613 |
MAPKAPK5 |
0.776 | -0.146 | -3 | 0.596 |
ERK1 |
0.776 | -0.031 | 1 | 0.552 |
PASK |
0.776 | -0.022 | -3 | 0.725 |
P38G |
0.776 | -0.015 | 1 | 0.470 |
CK2A1 |
0.776 | 0.094 | 1 | 0.739 |
CAMKK1 |
0.776 | -0.059 | -2 | 0.794 |
MST3 |
0.776 | -0.059 | 2 | 0.825 |
DAPK3 |
0.776 | 0.008 | -3 | 0.710 |
DCAMKL2 |
0.775 | -0.048 | -3 | 0.739 |
ERK2 |
0.775 | -0.054 | 1 | 0.588 |
TAO3 |
0.775 | -0.027 | 1 | 0.733 |
IRAK4 |
0.775 | -0.111 | 1 | 0.751 |
PHKG2 |
0.775 | -0.067 | -3 | 0.737 |
CK1E |
0.774 | -0.070 | -3 | 0.505 |
GRK3 |
0.774 | -0.032 | -2 | 0.617 |
TTBK1 |
0.774 | -0.114 | 2 | 0.625 |
GSK3B |
0.773 | -0.037 | 4 | 0.386 |
CAMK1D |
0.773 | -0.044 | -3 | 0.610 |
CDK13 |
0.773 | -0.081 | 1 | 0.562 |
HIPK1 |
0.772 | -0.048 | 1 | 0.648 |
NEK8 |
0.772 | -0.094 | 2 | 0.798 |
MST2 |
0.772 | -0.005 | 1 | 0.765 |
PAK5 |
0.772 | -0.015 | -2 | 0.638 |
PKCT |
0.771 | -0.082 | 2 | 0.713 |
CDK17 |
0.771 | -0.042 | 1 | 0.470 |
CDK3 |
0.771 | 0.004 | 1 | 0.494 |
WNK4 |
0.770 | -0.175 | -2 | 0.824 |
GSK3A |
0.770 | -0.023 | 4 | 0.395 |
CK1G1 |
0.769 | -0.078 | -3 | 0.510 |
IRAK1 |
0.769 | -0.202 | -1 | 0.758 |
P38D |
0.768 | -0.000 | 1 | 0.489 |
DAPK1 |
0.768 | -0.014 | -3 | 0.691 |
CDK9 |
0.768 | -0.092 | 1 | 0.569 |
TAK1 |
0.768 | -0.021 | 1 | 0.767 |
ERK7 |
0.768 | 0.014 | 2 | 0.556 |
DYRK4 |
0.767 | -0.033 | 1 | 0.559 |
TAO2 |
0.767 | -0.090 | 2 | 0.820 |
HIPK2 |
0.767 | -0.048 | 1 | 0.543 |
EEF2K |
0.767 | -0.028 | 3 | 0.845 |
CDK16 |
0.767 | -0.024 | 1 | 0.485 |
CK1D |
0.766 | -0.067 | -3 | 0.457 |
CDK14 |
0.766 | -0.044 | 1 | 0.560 |
DYRK1A |
0.766 | -0.082 | 1 | 0.652 |
PAK4 |
0.766 | -0.019 | -2 | 0.637 |
MRCKB |
0.766 | 0.007 | -3 | 0.656 |
DYRK3 |
0.766 | -0.052 | 1 | 0.656 |
AKT3 |
0.765 | -0.009 | -3 | 0.529 |
CAMKK2 |
0.765 | -0.116 | -2 | 0.791 |
NEK4 |
0.765 | -0.106 | 1 | 0.735 |
PKCI |
0.765 | -0.085 | 2 | 0.728 |
CHK2 |
0.764 | -0.044 | -3 | 0.567 |
CDK12 |
0.764 | -0.085 | 1 | 0.535 |
CK1A2 |
0.764 | -0.070 | -3 | 0.458 |
LOK |
0.763 | -0.041 | -2 | 0.808 |
TNIK |
0.763 | -0.028 | 3 | 0.862 |
LKB1 |
0.763 | -0.121 | -3 | 0.719 |
MINK |
0.763 | -0.065 | 1 | 0.742 |
GCK |
0.763 | -0.065 | 1 | 0.747 |
MRCKA |
0.763 | -0.009 | -3 | 0.667 |
NEK11 |
0.763 | -0.207 | 1 | 0.722 |
HIPK3 |
0.763 | -0.088 | 1 | 0.637 |
SGK1 |
0.763 | -0.016 | -3 | 0.513 |
TTK |
0.762 | 0.110 | -2 | 0.850 |
JNK1 |
0.762 | -0.019 | 1 | 0.525 |
PDK1 |
0.762 | -0.128 | 1 | 0.714 |
PKCE |
0.762 | -0.052 | 2 | 0.700 |
HGK |
0.762 | -0.078 | 3 | 0.863 |
MEK2 |
0.761 | -0.107 | 2 | 0.807 |
DYRK1B |
0.761 | -0.071 | 1 | 0.580 |
PKN1 |
0.760 | -0.075 | -3 | 0.633 |
MST1 |
0.759 | -0.077 | 1 | 0.743 |
ROCK2 |
0.759 | 0.002 | -3 | 0.680 |
MPSK1 |
0.759 | -0.115 | 1 | 0.706 |
CAMK1A |
0.759 | -0.052 | -3 | 0.591 |
CDK10 |
0.759 | -0.055 | 1 | 0.546 |
MEKK6 |
0.759 | -0.141 | 1 | 0.753 |
SLK |
0.759 | -0.048 | -2 | 0.735 |
VRK1 |
0.758 | -0.118 | 2 | 0.805 |
HPK1 |
0.757 | -0.082 | 1 | 0.734 |
NEK1 |
0.757 | -0.111 | 1 | 0.742 |
LRRK2 |
0.756 | -0.176 | 2 | 0.829 |
DMPK1 |
0.756 | 0.021 | -3 | 0.692 |
PKG1 |
0.756 | 0.002 | -2 | 0.662 |
PDHK3_TYR |
0.756 | 0.082 | 4 | 0.785 |
SBK |
0.755 | -0.047 | -3 | 0.502 |
TXK |
0.754 | 0.246 | 1 | 0.856 |
BUB1 |
0.754 | -0.017 | -5 | 0.622 |
MAP3K15 |
0.753 | -0.172 | 1 | 0.705 |
CDK6 |
0.753 | -0.047 | 1 | 0.536 |
STK33 |
0.753 | -0.157 | 2 | 0.632 |
KHS2 |
0.752 | -0.040 | 1 | 0.736 |
RIPK2 |
0.752 | -0.218 | 1 | 0.681 |
KHS1 |
0.752 | -0.065 | 1 | 0.727 |
EPHA6 |
0.752 | 0.126 | -1 | 0.858 |
OSR1 |
0.751 | -0.011 | 2 | 0.804 |
YSK1 |
0.751 | -0.111 | 2 | 0.786 |
MOK |
0.749 | -0.043 | 1 | 0.685 |
PBK |
0.749 | -0.066 | 1 | 0.708 |
MAP2K6_TYR |
0.748 | 0.023 | -1 | 0.835 |
CDK4 |
0.748 | -0.063 | 1 | 0.523 |
EPHB4 |
0.748 | 0.124 | -1 | 0.849 |
ROCK1 |
0.748 | -0.014 | -3 | 0.664 |
NEK3 |
0.747 | -0.133 | 1 | 0.700 |
BMPR2_TYR |
0.747 | 0.017 | -1 | 0.828 |
PDHK4_TYR |
0.746 | -0.007 | 2 | 0.878 |
BIKE |
0.746 | -0.008 | 1 | 0.653 |
MAP2K4_TYR |
0.746 | -0.049 | -1 | 0.843 |
PDHK1_TYR |
0.745 | 0.010 | -1 | 0.861 |
MAK |
0.745 | -0.045 | -2 | 0.651 |
ALPHAK3 |
0.745 | 0.019 | -1 | 0.743 |
ITK |
0.745 | 0.138 | -1 | 0.829 |
TESK1_TYR |
0.744 | -0.127 | 3 | 0.896 |
YES1 |
0.744 | 0.116 | -1 | 0.870 |
SRMS |
0.744 | 0.148 | 1 | 0.861 |
CRIK |
0.744 | -0.034 | -3 | 0.597 |
BLK |
0.743 | 0.178 | -1 | 0.860 |
EPHB1 |
0.742 | 0.121 | 1 | 0.855 |
TEC |
0.742 | 0.145 | -1 | 0.804 |
FER |
0.742 | 0.056 | 1 | 0.866 |
EPHB2 |
0.741 | 0.139 | -1 | 0.841 |
LCK |
0.741 | 0.133 | -1 | 0.856 |
MAP2K7_TYR |
0.741 | -0.219 | 2 | 0.844 |
TYRO3 |
0.741 | 0.024 | 3 | 0.828 |
EPHA4 |
0.740 | 0.074 | 2 | 0.780 |
PINK1_TYR |
0.740 | -0.150 | 1 | 0.775 |
MYO3A |
0.740 | -0.069 | 1 | 0.728 |
MYO3B |
0.739 | -0.082 | 2 | 0.798 |
ABL2 |
0.739 | 0.073 | -1 | 0.820 |
RET |
0.739 | -0.052 | 1 | 0.745 |
HCK |
0.739 | 0.089 | -1 | 0.858 |
EPHB3 |
0.739 | 0.089 | -1 | 0.845 |
PKMYT1_TYR |
0.737 | -0.197 | 3 | 0.870 |
FGR |
0.737 | 0.013 | 1 | 0.818 |
LIMK2_TYR |
0.737 | -0.067 | -3 | 0.781 |
HASPIN |
0.737 | -0.069 | -1 | 0.636 |
BMX |
0.736 | 0.084 | -1 | 0.747 |
ABL1 |
0.736 | 0.061 | -1 | 0.824 |
ROS1 |
0.735 | -0.042 | 3 | 0.810 |
CSF1R |
0.734 | -0.013 | 3 | 0.811 |
MERTK |
0.733 | 0.080 | 3 | 0.805 |
INSRR |
0.733 | -0.013 | 3 | 0.798 |
EPHA7 |
0.733 | 0.081 | 2 | 0.783 |
MST1R |
0.733 | -0.089 | 3 | 0.830 |
YANK3 |
0.733 | -0.088 | 2 | 0.427 |
FYN |
0.733 | 0.118 | -1 | 0.825 |
STLK3 |
0.732 | -0.103 | 1 | 0.701 |
TYK2 |
0.732 | -0.137 | 1 | 0.746 |
CK1A |
0.732 | -0.088 | -3 | 0.382 |
TNK2 |
0.732 | 0.029 | 3 | 0.794 |
BTK |
0.731 | 0.036 | -1 | 0.815 |
AXL |
0.731 | 0.026 | 3 | 0.810 |
TAO1 |
0.731 | -0.133 | 1 | 0.660 |
ASK1 |
0.730 | -0.204 | 1 | 0.692 |
JAK2 |
0.730 | -0.106 | 1 | 0.743 |
DDR1 |
0.730 | -0.145 | 4 | 0.681 |
LYN |
0.729 | 0.082 | 3 | 0.750 |
AAK1 |
0.729 | 0.013 | 1 | 0.551 |
TEK |
0.729 | -0.035 | 3 | 0.791 |
FLT3 |
0.729 | -0.035 | 3 | 0.820 |
LIMK1_TYR |
0.728 | -0.234 | 2 | 0.824 |
JAK3 |
0.728 | -0.091 | 1 | 0.723 |
PTK2B |
0.727 | 0.084 | -1 | 0.834 |
PDGFRB |
0.727 | -0.073 | 3 | 0.833 |
EPHA5 |
0.727 | 0.078 | 2 | 0.771 |
KIT |
0.727 | -0.055 | 3 | 0.819 |
FRK |
0.727 | 0.050 | -1 | 0.877 |
FGFR2 |
0.727 | -0.081 | 3 | 0.836 |
LTK |
0.726 | -0.001 | 3 | 0.778 |
EPHA3 |
0.726 | -0.004 | 2 | 0.754 |
EPHA1 |
0.725 | 0.016 | 3 | 0.794 |
EPHA8 |
0.724 | 0.052 | -1 | 0.816 |
PTK6 |
0.724 | -0.047 | -1 | 0.757 |
ALK |
0.723 | -0.041 | 3 | 0.765 |
SRC |
0.723 | 0.064 | -1 | 0.837 |
FGFR1 |
0.722 | -0.089 | 3 | 0.807 |
MET |
0.722 | -0.047 | 3 | 0.810 |
KDR |
0.722 | -0.083 | 3 | 0.788 |
PTK2 |
0.720 | 0.068 | -1 | 0.762 |
NEK10_TYR |
0.720 | -0.110 | 1 | 0.604 |
TNNI3K_TYR |
0.720 | -0.079 | 1 | 0.787 |
NTRK1 |
0.719 | -0.092 | -1 | 0.795 |
ERBB2 |
0.718 | -0.100 | 1 | 0.709 |
JAK1 |
0.717 | -0.079 | 1 | 0.680 |
FLT1 |
0.717 | -0.085 | -1 | 0.805 |
FGFR3 |
0.717 | -0.083 | 3 | 0.811 |
MATK |
0.716 | -0.054 | -1 | 0.730 |
TNK1 |
0.716 | -0.130 | 3 | 0.810 |
NTRK2 |
0.716 | -0.086 | 3 | 0.784 |
PDGFRA |
0.716 | -0.168 | 3 | 0.830 |
CK1G3 |
0.715 | -0.081 | -3 | 0.342 |
CSK |
0.714 | -0.036 | 2 | 0.782 |
WEE1_TYR |
0.714 | -0.119 | -1 | 0.744 |
INSR |
0.714 | -0.103 | 3 | 0.771 |
FLT4 |
0.713 | -0.118 | 3 | 0.786 |
SYK |
0.713 | 0.039 | -1 | 0.745 |
EPHA2 |
0.713 | 0.021 | -1 | 0.777 |
EGFR |
0.712 | -0.032 | 1 | 0.625 |
NTRK3 |
0.712 | -0.072 | -1 | 0.745 |
DDR2 |
0.710 | -0.075 | 3 | 0.784 |
FGFR4 |
0.710 | -0.032 | -1 | 0.766 |
ERBB4 |
0.704 | -0.022 | 1 | 0.672 |
IGF1R |
0.702 | -0.083 | 3 | 0.723 |
YANK2 |
0.701 | -0.110 | 2 | 0.438 |
FES |
0.698 | -0.036 | -1 | 0.733 |
MUSK |
0.694 | -0.146 | 1 | 0.607 |
CK1G2 |
0.692 | -0.099 | -3 | 0.433 |
ZAP70 |
0.679 | -0.077 | -1 | 0.654 |