Motif 646 (n=262)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6H8Y1 | BDP1 | S1621 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A8CG34 | POM121C | S443 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00291 | HIP1 | S516 | ochoa | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}. |
| O00311 | CDC7 | S216 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00443 | PIK3C2A | S108 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O00622 | CCN1 | S84 | ochoa | CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}. |
| O14654 | IRS4 | S918 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14745 | NHERF1 | S77 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14967 | CLGN | S591 | ochoa | Calmegin | Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}. |
| O15014 | ZNF609 | S778 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15037 | KHNYN | S291 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15446 | POLR1G | S309 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43148 | RNMT | S70 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43298 | ZBTB43 | S200 | ochoa | Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) | May be involved in transcriptional regulation. |
| O43663 | PRC1 | S554 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43791 | SPOP | S119 | psp | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}. |
| O60271 | SPAG9 | S268 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60610 | DIAPH1 | S208 | ochoa | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O60664 | PLIN3 | S374 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60716 | CTNND1 | S225 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75150 | RNF40 | S819 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75152 | ZC3H11A | S370 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75152 | ZC3H11A | S781 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75410 | TACC1 | S147 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75899 | GABBR2 | S776 | ochoa | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}. |
| O75914 | PAK3 | S272 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O94913 | PCF11 | S395 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94986 | CEP152 | S1552 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95155 | UBE4B | S798 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95210 | STBD1 | S211 | ochoa|psp | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95359 | TACC2 | S2533 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95400 | CD2BP2 | S60 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| O95835 | LATS1 | S674 | psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P02144 | MB | S93 | ochoa | Myoglobin (Nitrite reductase MB) (EC 1.7.-.-) (Pseudoperoxidase MB) (EC 1.11.1.-) | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). {ECO:0000269|PubMed:30918256, ECO:0000269|PubMed:32891753, ECO:0000269|PubMed:34679218}. |
| P04350 | TUBB4A | S335 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P06241 | FYN | S186 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07311 | ACYP1 | S71 | ochoa | Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1) | None |
| P07339 | CTSD | S359 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| P07451 | CA3 | S242 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P07858 | CTSB | S83 | ochoa | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}. |
| P07947 | YES1 | S195 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | S166 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P09769 | FGR | S181 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0C7T5 | ATXN1L | S292 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0DJ93 | SMIM13 | S50 | ochoa | Small integral membrane protein 13 | None |
| P10645 | CHGA | S113 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11142 | HSPA8 | S537 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11171 | EPB41 | S664 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11277 | SPTB | S1829 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P11441 | UBL4A | S90 | ochoa | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}. |
| P11940 | PABPC1 | S315 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12882 | MYH1 | S1832 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P13533 | MYH6 | S1720 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P15822 | HIVEP1 | S1048 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16591 | FER | S423 | ochoa | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}. |
| P17480 | UBTF | S364 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P17706 | PTPN2 | S298 | ochoa | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}. |
| P21359 | NF1 | S2587 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P21796 | VDAC1 | S43 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P25054 | APC | S1906 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27707 | DCK | S74 | ochoa|psp | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P28715 | ERCC5 | S705 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P30260 | CDC27 | S435 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30533 | LRPAP1 | S310 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P32248 | CCR7 | S357 | psp | C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) | Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. |
| P33981 | TTK | S37 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P33981 | TTK | S42 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P34910 | EVI2B | S268 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35251 | RFC1 | S552 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35749 | MYH11 | S1722 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37059 | HSD17B2 | S234 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P38432 | COIL | S462 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P46013 | MKI67 | S171 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46063 | RECQL | S58 | ochoa | ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:19151156, ECO:0000269|PubMed:25831490, ECO:0000269|PubMed:35025765, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}. |
| P47710 | CSN1S1 | S88 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P48681 | NES | S768 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S809 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S831 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S894 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P50579 | METAP2 | S60 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P50851 | LRBA | S1261 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P52597 | HNRNPF | S32 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P53794 | SLC5A3 | S632 | ochoa | Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}. |
| P54296 | MYOM2 | S91 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P60891 | PRPS1 | S285 | psp | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P78344 | EIF4G2 | S602 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78352 | DLG4 | S561 | psp | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P78527 | PRKDC | S511 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q00537 | CDK17 | S146 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q01780 | EXOSC10 | S821 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q01814 | ATP2B2 | S1160 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q01814 | ATP2B2 | S1163 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q01968 | OCRL | S716 | ochoa | Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:25869668, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:15474001, ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:7761412, ECO:0000269|PubMed:9430698}. |
| Q07021 | C1QBP | S205 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q07866 | KLC1 | S521 | ochoa|psp | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q08211 | DHX9 | S279 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12802 | AKAP13 | S2436 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12830 | BPTF | S2682 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12923 | PTPN13 | S2171 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12955 | ANK3 | S1459 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13153 | PAK1 | S259 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13263 | TRIM28 | S784 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13310 | PABPC4 | S315 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13393 | PLD1 | S45 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13426 | XRCC4 | S304 | ochoa|psp | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13427 | PPIG | S544 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13895 | BYSL | S170 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q14116 | IL18 | S35 | ochoa | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) | Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993714}. |
| Q14141 | SEPTIN6 | S411 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14160 | SCRIB | S37 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14202 | ZMYM3 | S950 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14244 | MAP7 | S308 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14677 | CLINT1 | S210 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14847 | LASP1 | S134 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14966 | ZNF638 | S1697 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15185 | PTGES3 | S39 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15276 | RABEP1 | S491 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15326 | ZMYND11 | S419 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15398 | DLGAP5 | S787 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q16206 | ENOX2 | S504 | psp | Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}. |
| Q16649 | NFIL3 | S353 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
| Q19T08 | ECSCR | S165 | ochoa | Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2) | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}. |
| Q27J81 | INF2 | S23 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q3V6T2 | CCDC88A | S1020 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53H47 | SETMAR | S410 | ochoa | Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] | Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17403897, PubMed:17877369, PubMed:18263876, PubMed:20521842, PubMed:22231448, PubMed:24573677). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269|PubMed:16332963, ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897, ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842, ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448, ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}. |
| Q53HL2 | CDCA8 | S244 | ochoa | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q5JQS6 | GCSAML | S116 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5QJE6 | DNTTIP2 | S145 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | S151 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SNT2 | TMEM201 | S615 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5T200 | ZC3H13 | S1406 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5X7 | BEND3 | S33 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q6P0N0 | MIS18BP1 | S175 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P2Q9 | PRPF8 | S2060 | ochoa | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}. |
| Q6P4R8 | NFRKB | S338 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PCB8 | EMB | S306 | ochoa | Embigin | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}. |
| Q6PCB8 | EMB | S309 | ochoa | Embigin | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}. |
| Q6PKG0 | LARP1 | S700 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6VN20 | RANBP10 | S489 | ochoa | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q6WCQ1 | MPRIP | S671 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZN28 | MACC1 | S115 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q71F23 | CENPU | S170 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71RC2 | LARP4 | S74 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7L0Y3 | TRMT10C | S83 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7L2Z9 | CENPQ | S139 | psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7L8S5 | OTUD6A | S71 | psp | OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2) | Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. {ECO:0000269|PubMed:23827681}. |
| Q7Z4H7 | HAUS6 | S510 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q86SF2 | GALNT7 | S103 | ochoa | N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) | Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. {ECO:0000269|PubMed:10544240, ECO:0000269|PubMed:11925450}. |
| Q86XP3 | DDX42 | S185 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q86YA3 | ZGRF1 | S793 | ochoa | 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) | 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219). {ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:34552057}. |
| Q86YC2 | PALB2 | S380 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q86YV0 | RASAL3 | S224 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IUI4 | SNX29P2 | S208 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IX03 | WWC1 | S833 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IY18 | SMC5 | S792 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IZ40 | RCOR2 | S213 | ochoa | REST corepressor 2 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q8N1W1 | ARHGEF28 | S325 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N4Y2 | CRACR2B | S174 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8N5C7 | DTWD1 | S192 | ochoa | tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1) | Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)). {ECO:0000269|PubMed:31804502}. |
| Q8NB12 | SMYD1 | S321 | ochoa | Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1) | Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. {ECO:0000250|UniProtKB:P97443}. |
| Q8NBJ4 | GOLM1 | S86 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8NCN4 | RNF169 | S553 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NF91 | SYNE1 | S8664 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFP9 | NBEA | S1011 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8NFP9 | NBEA | S1731 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8NG31 | KNL1 | S1773 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TC05 | MDM1 | S686 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TDW5 | SYTL5 | S482 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TEQ0 | SNX29 | S361 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEW8 | PARD3B | S90 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TEY7 | USP33 | S387 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
| Q8WV83 | SLC35F5 | S208 | ochoa | Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3) | Putative solute transporter. {ECO:0000305}. |
| Q8WYP5 | AHCTF1 | S2181 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92556 | ELMO1 | S344 | ochoa | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}. |
| Q92576 | PHF3 | S419 | ochoa | PHD finger protein 3 | None |
| Q92599 | SEPTIN8 | S141 | ochoa | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92614 | MYO18A | S1640 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92621 | NUP205 | S1167 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q92692 | NECTIN2 | S405 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q969F1 | GTF3C6 | S174 | ochoa | General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}. |
| Q96BP3 | PPWD1 | S464 | ochoa | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:20676357}. |
| Q96DG6 | CMBL | S208 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q96EY4 | TMA16 | S97 | ochoa | Translation machinery-associated protein 16 | Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. {ECO:0000269|PubMed:32669547}. |
| Q96GA3 | LTV1 | S358 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96HA1 | POM121 | S466 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96I25 | RBM17 | S202 | psp | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96J84 | KIRREL1 | S562 | ochoa | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q96L73 | NSD1 | S1143 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96QT4 | TRPM7 | S1476 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RS0 | TGS1 | S578 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99572 | P2RX7 | S390 | ochoa | P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) | ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:17483156, PubMed:25281740, PubMed:9038151). Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux (PubMed:17483156, PubMed:20453110, PubMed:28235784, PubMed:39262850). Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules (PubMed:17483156). In microglia, may mediate NADPH transport across the plasma membrane (PubMed:39142135). In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1 (PubMed:26877061). Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy (PubMed:21821797, PubMed:23303206, PubMed:28326637). Activates death pathways leading to pyroptosis (By similarity). {ECO:0000250|UniProtKB:Q9Z1M0, ECO:0000269|PubMed:17483156, ECO:0000269|PubMed:20453110, ECO:0000269|PubMed:21821797, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:25281740, ECO:0000269|PubMed:26877061, ECO:0000269|PubMed:28235784, ECO:0000269|PubMed:28326637, ECO:0000269|PubMed:39142135, ECO:0000269|PubMed:39262850, ECO:0000269|PubMed:9038151}.; FUNCTION: [Isoform B]: Shows ion channel activity but no macropore function. {ECO:0000269|PubMed:20453110}.; FUNCTION: [Isoform H]: Non-functional channel. {ECO:0000269|PubMed:15896293}.; FUNCTION: [Isoform J]: Non-functional channel. {ECO:0000269|PubMed:16624800}. |
| Q99590 | SCAF11 | S614 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BQ39 | DDX50 | S112 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BRK4 | LZTS2 | S346 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BT25 | HAUS8 | S151 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTT6 | LRRC1 | S37 | ochoa | Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) | None |
| Q9BWH2 | FUNDC2 | S151 | ochoa | FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6) | Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}. |
| Q9BZI7 | UPF3B | S166 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0C2 | TNKS1BP1 | S1678 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV1 | ANKRD2 | S83 | ochoa | Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp) | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}. |
| Q9H2G4 | TSPYL2 | S182 | ochoa | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
| Q9H3Q1 | CDC42EP4 | S105 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9HAW4 | CLSPN | S945 | ochoa|psp | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HC77 | CPAP | S589 | psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQS7 | INCENP | S476 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NUA8 | ZBTB40 | S703 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NWQ8 | PAG1 | S282 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NZ63 | C9orf78 | S101 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9P0K7 | RAI14 | S386 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0K7 | RAI14 | S667 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P260 | RELCH | S341 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UBW5 | BIN2 | S90 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UEY8 | ADD3 | S589 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UH99 | SUN2 | S266 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UHD2 | TBK1 | S172 | ochoa|psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UII2 | ATP5IF1 | S63 | ochoa|psp | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. |
| Q9UJY4 | GGA2 | S233 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UKX2 | MYH2 | S1834 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULL0 | KIAA1210 | S818 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9UN19 | DAPP1 | S141 | ochoa|psp | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9UNF1 | MAGED2 | S194 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UNW9 | NOVA2 | S194 | psp | RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) | Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion (PubMed:32197073). It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons (PubMed:10811881). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (By similarity). {ECO:0000250|UniProtKB:A0A1W2P872, ECO:0000269|PubMed:10811881, ECO:0000269|PubMed:32197073}. |
| Q9Y294 | ASF1A | S165 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y297 | BTRC | S158 | psp | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}. |
| Q9Y2K6 | USP20 | S289 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2R2 | PTPN22 | S414 | ochoa | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
| Q9Y2Y0 | ARL2BP | S140 | ochoa | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) | Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}. |
| Q9Y3E5 | PTRH2 | S62 | ochoa | Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) | Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269|PubMed:14660562, ECO:0000269|PubMed:15006356}. |
| Q9Y4G8 | RAPGEF2 | S1325 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| R4GMW8 | BIVM-ERCC5 | S1159 | ochoa | DNA excision repair protein ERCC-5 | None |
| P30050 | RPL12 | S138 | Sugiyama | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P07900 | HSP90AA1 | S165 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S160 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q14568 | HSP90AA2P | S165 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| C4AMC7 | WASH3P | S105 | Sugiyama | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| P25208 | NFYB | S95 | Sugiyama | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| P62942 | FKBP1A | S68 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) | Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}. |
| Q6VEQ5 | WASH2P | S105 | Sugiyama | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q92621 | NUP205 | S1857 | Sugiyama | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q9NQA3 | WASH6P | S87 | Sugiyama | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q8TDY2 | RB1CC1 | S943 | PSP | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| O75676 | RPS6KA4 | S87 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| Q4G0X9 | CCDC40 | S553 | Sugiyama | Coiled-coil domain-containing protein 40 | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}. |
| P50990 | CCT8 | S425 | Sugiyama | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P11388 | TOP2A | S29 | SIGNOR|iPTMNet|EPSD | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| Q14247 | CTTN | S332 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| P33176 | KIF5B | S717 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P08684 | CYP3A4 | S131 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P29597 | TYK2 | S912 | Sugiyama | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| P78371 | CCT2 | S101 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P13073 | COX4I1 | S71 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| Q92878 | RAD50 | S703 | Sugiyama | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q08881 | ITK | S71 | Sugiyama | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q12906 | ILF3 | S36 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13451 | FKBP5 | S27 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q16658 | FSCN1 | S259 | Sugiyama | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| P54577 | YARS1 | S366 | Sugiyama | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}. |
| Q15751 | HERC1 | S2436 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| O60763 | USO1 | S883 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| Q9P0L2 | MARK1 | S383 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| P04920 | SLC4A2 | S56 | Sugiyama | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| Q9NSC5 | HOMER3 | S176 | SIGNOR | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 4.319884e-07 | 6.365 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.056801e-06 | 5.976 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.889865e-06 | 5.311 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.763366e-05 | 4.559 |
| R-HSA-68877 | Mitotic Prometaphase | 1.434700e-04 | 3.843 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.950124e-04 | 3.530 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.859160e-04 | 3.414 |
| R-HSA-68886 | M Phase | 4.137938e-04 | 3.383 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.777728e-04 | 3.238 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.462878e-04 | 3.072 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.333540e-04 | 3.079 |
| R-HSA-9012546 | Interleukin-18 signaling | 1.085998e-03 | 2.964 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.689653e-03 | 2.772 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.689653e-03 | 2.772 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.904352e-04 | 3.004 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.497631e-03 | 2.825 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.449134e-03 | 2.839 |
| R-HSA-69275 | G2/M Transition | 1.343333e-03 | 2.872 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.697219e-03 | 2.770 |
| R-HSA-422475 | Axon guidance | 1.486251e-03 | 2.828 |
| R-HSA-449147 | Signaling by Interleukins | 1.524611e-03 | 2.817 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.227303e-03 | 2.911 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.923780e-03 | 2.716 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.923780e-03 | 2.716 |
| R-HSA-373755 | Semaphorin interactions | 1.923780e-03 | 2.716 |
| R-HSA-210990 | PECAM1 interactions | 2.152411e-03 | 2.667 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.222482e-03 | 2.653 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.359705e-03 | 2.627 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.655978e-03 | 2.576 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.634587e-03 | 2.579 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.480046e-03 | 2.606 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.689065e-03 | 2.570 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.121438e-03 | 2.506 |
| R-HSA-9675108 | Nervous system development | 3.122782e-03 | 2.505 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.298112e-03 | 2.482 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 3.705299e-03 | 2.431 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.662685e-03 | 2.436 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.603696e-03 | 2.443 |
| R-HSA-380287 | Centrosome maturation | 4.117576e-03 | 2.385 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.067524e-03 | 2.391 |
| R-HSA-68882 | Mitotic Anaphase | 3.915120e-03 | 2.407 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.038723e-03 | 2.394 |
| R-HSA-1433559 | Regulation of KIT signaling | 4.341262e-03 | 2.362 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.241193e-03 | 2.373 |
| R-HSA-1538133 | G0 and Early G1 | 5.121734e-03 | 2.291 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.546165e-03 | 2.256 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.031246e-03 | 2.220 |
| R-HSA-8953854 | Metabolism of RNA | 6.386271e-03 | 2.195 |
| R-HSA-162582 | Signal Transduction | 6.607274e-03 | 2.180 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 7.191391e-03 | 2.143 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.551567e-03 | 2.068 |
| R-HSA-72172 | mRNA Splicing | 7.755711e-03 | 2.110 |
| R-HSA-3928664 | Ephrin signaling | 8.485331e-03 | 2.071 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.388242e-03 | 2.027 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 9.146768e-03 | 2.039 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.159816e-03 | 2.088 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 9.283472e-03 | 2.032 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 8.485331e-03 | 2.071 |
| R-HSA-912631 | Regulation of signaling by CBL | 9.516382e-03 | 2.022 |
| R-HSA-9663891 | Selective autophagy | 8.551567e-03 | 2.068 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 7.191391e-03 | 2.143 |
| R-HSA-1227986 | Signaling by ERBB2 | 8.016120e-03 | 2.096 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.815857e-03 | 2.055 |
| R-HSA-168256 | Immune System | 9.427026e-03 | 2.026 |
| R-HSA-373760 | L1CAM interactions | 9.571363e-03 | 2.019 |
| R-HSA-3371568 | Attenuation phase | 1.058966e-02 | 1.975 |
| R-HSA-5693538 | Homology Directed Repair | 1.034050e-02 | 1.985 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.058966e-02 | 1.975 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.061735e-02 | 1.974 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 9.851072e-03 | 2.007 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.136313e-02 | 1.945 |
| R-HSA-3371556 | Cellular response to heat stress | 1.157726e-02 | 1.936 |
| R-HSA-73886 | Chromosome Maintenance | 1.157726e-02 | 1.936 |
| R-HSA-164944 | Nef and signal transduction | 1.161279e-02 | 1.935 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.217204e-02 | 1.915 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.381104e-02 | 1.860 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.291775e-02 | 1.889 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.389836e-02 | 1.857 |
| R-HSA-9612973 | Autophagy | 1.398618e-02 | 1.854 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.417034e-02 | 1.849 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.573530e-02 | 1.803 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.434749e-02 | 1.843 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.471297e-02 | 1.832 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.434749e-02 | 1.843 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.577270e-02 | 1.802 |
| R-HSA-774815 | Nucleosome assembly | 1.577270e-02 | 1.802 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.577270e-02 | 1.802 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.694735e-02 | 1.771 |
| R-HSA-429947 | Deadenylation of mRNA | 1.719607e-02 | 1.765 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.719607e-02 | 1.765 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.598593e-02 | 1.796 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.676654e-02 | 1.776 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.755597e-02 | 1.756 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.772643e-02 | 1.751 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.886965e-02 | 1.724 |
| R-HSA-9613354 | Lipophagy | 1.993530e-02 | 1.700 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.993530e-02 | 1.700 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.033761e-02 | 1.692 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.312589e-02 | 1.636 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.231848e-02 | 1.651 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.312589e-02 | 1.636 |
| R-HSA-9833482 | PKR-mediated signaling | 2.191826e-02 | 1.659 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.083246e-02 | 1.681 |
| R-HSA-202403 | TCR signaling | 2.356415e-02 | 1.628 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.384354e-02 | 1.623 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.481758e-02 | 1.605 |
| R-HSA-1632852 | Macroautophagy | 2.482361e-02 | 1.605 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.560185e-02 | 1.592 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.750370e-02 | 1.561 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.947886e-02 | 1.530 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.947886e-02 | 1.530 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.947886e-02 | 1.530 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.977588e-02 | 1.526 |
| R-HSA-5688426 | Deubiquitination | 2.777896e-02 | 1.556 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.747905e-02 | 1.561 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 3.008291e-02 | 1.522 |
| R-HSA-69109 | Leading Strand Synthesis | 3.383387e-02 | 1.471 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 3.383387e-02 | 1.471 |
| R-HSA-69091 | Polymerase switching | 3.383387e-02 | 1.471 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.364800e-02 | 1.473 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.364800e-02 | 1.473 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 3.008291e-02 | 1.522 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.364800e-02 | 1.473 |
| R-HSA-191859 | snRNP Assembly | 3.329561e-02 | 1.478 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.329561e-02 | 1.478 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 3.008291e-02 | 1.522 |
| R-HSA-983189 | Kinesins | 3.485344e-02 | 1.458 |
| R-HSA-428540 | Activation of RAC1 | 3.008291e-02 | 1.522 |
| R-HSA-913531 | Interferon Signaling | 3.158713e-02 | 1.500 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 3.513970e-02 | 1.454 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 3.513970e-02 | 1.454 |
| R-HSA-162906 | HIV Infection | 3.536419e-02 | 1.451 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.584129e-02 | 1.446 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.584129e-02 | 1.446 |
| R-HSA-5617833 | Cilium Assembly | 3.601535e-02 | 1.444 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 3.775649e-02 | 1.423 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.808813e-02 | 1.419 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.810648e-02 | 1.419 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.810648e-02 | 1.419 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.810648e-02 | 1.419 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.044308e-02 | 1.393 |
| R-HSA-194138 | Signaling by VEGF | 4.155099e-02 | 1.381 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.049189e-02 | 1.297 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 4.608802e-02 | 1.336 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.692755e-02 | 1.329 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 4.608802e-02 | 1.336 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.285055e-02 | 1.368 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.532828e-02 | 1.344 |
| R-HSA-3371511 | HSF1 activation | 4.285055e-02 | 1.368 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.532828e-02 | 1.344 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 5.048310e-02 | 1.297 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.049189e-02 | 1.297 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 5.224533e-02 | 1.282 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.317634e-02 | 1.274 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.317634e-02 | 1.274 |
| R-HSA-202433 | Generation of second messenger molecules | 5.317634e-02 | 1.274 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 5.502214e-02 | 1.259 |
| R-HSA-1483148 | Synthesis of PG | 5.502214e-02 | 1.259 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.904874e-02 | 1.161 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.904874e-02 | 1.161 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.904874e-02 | 1.161 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.904874e-02 | 1.161 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.904874e-02 | 1.161 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.904874e-02 | 1.161 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.904874e-02 | 1.161 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 6.904874e-02 | 1.161 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.904874e-02 | 1.161 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.904874e-02 | 1.161 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.904874e-02 | 1.161 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.904874e-02 | 1.161 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 6.450653e-02 | 1.190 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 6.943952e-02 | 1.158 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.592822e-02 | 1.252 |
| R-HSA-844456 | The NLRP3 inflammasome | 6.943952e-02 | 1.158 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 6.943952e-02 | 1.158 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.680209e-02 | 1.246 |
| R-HSA-2028269 | Signaling by Hippo | 5.969871e-02 | 1.224 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.592822e-02 | 1.252 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.486098e-02 | 1.188 |
| R-HSA-9664407 | Parasite infection | 6.486098e-02 | 1.188 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.486098e-02 | 1.188 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.680209e-02 | 1.246 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.918185e-02 | 1.228 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.817464e-02 | 1.166 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.163095e-02 | 1.210 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 7.380759e-02 | 1.132 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 7.380759e-02 | 1.132 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7.449178e-02 | 1.128 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7.449178e-02 | 1.128 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.449178e-02 | 1.128 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.449178e-02 | 1.128 |
| R-HSA-373753 | Nephrin family interactions | 7.449178e-02 | 1.128 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 7.449178e-02 | 1.128 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 7.449178e-02 | 1.128 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.472632e-02 | 1.127 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.630623e-02 | 1.117 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 7.700692e-02 | 1.113 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 7.714627e-02 | 1.113 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.017701e-01 | 0.992 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.176984e-01 | 0.929 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.176984e-01 | 0.929 |
| R-HSA-68911 | G2 Phase | 1.176984e-01 | 0.929 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.333452e-01 | 0.875 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.487154e-01 | 0.828 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.487154e-01 | 0.828 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.638140e-01 | 0.786 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.786457e-01 | 0.748 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 1.932153e-01 | 0.714 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.932153e-01 | 0.714 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.075273e-01 | 0.683 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.075273e-01 | 0.683 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 2.075273e-01 | 0.683 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 8.493125e-02 | 1.071 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 8.493125e-02 | 1.071 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 8.493125e-02 | 1.071 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 8.493125e-02 | 1.071 |
| R-HSA-4839744 | Signaling by APC mutants | 2.215862e-01 | 0.654 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.215862e-01 | 0.654 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.215862e-01 | 0.654 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.215862e-01 | 0.654 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.353966e-01 | 0.628 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.069994e-01 | 0.971 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.489628e-01 | 0.604 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.489628e-01 | 0.604 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.489628e-01 | 0.604 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.489628e-01 | 0.604 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.489628e-01 | 0.604 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.489628e-01 | 0.604 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.489628e-01 | 0.604 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.185475e-01 | 0.926 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.622891e-01 | 0.581 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.622891e-01 | 0.581 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.303884e-01 | 0.885 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.753798e-01 | 0.560 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.753798e-01 | 0.560 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.882390e-01 | 0.540 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.882390e-01 | 0.540 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.882390e-01 | 0.540 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.882390e-01 | 0.540 |
| R-HSA-72187 | mRNA 3'-end processing | 9.388388e-02 | 1.027 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.610494e-01 | 0.793 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.008707e-01 | 0.522 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.008707e-01 | 0.522 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.008707e-01 | 0.522 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 3.132791e-01 | 0.504 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.132791e-01 | 0.504 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.516343e-01 | 0.599 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.779925e-01 | 0.556 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.911568e-01 | 0.536 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.911568e-01 | 0.536 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.977284e-01 | 0.526 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.835432e-01 | 0.736 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.835432e-01 | 0.736 |
| R-HSA-72649 | Translation initiation complex formation | 3.042906e-01 | 0.517 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.108417e-01 | 0.507 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.709212e-01 | 0.567 |
| R-HSA-69186 | Lagging Strand Synthesis | 7.965755e-02 | 1.099 |
| R-HSA-6798695 | Neutrophil degranulation | 9.070063e-02 | 1.042 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.303884e-01 | 0.885 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.882390e-01 | 0.540 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.122859e-01 | 0.673 |
| R-HSA-73893 | DNA Damage Bypass | 2.714036e-01 | 0.566 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.364077e-01 | 0.865 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.470317e-01 | 0.607 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.013466e-01 | 0.994 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.270205e-01 | 0.896 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.075273e-01 | 0.683 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 9.030747e-02 | 1.044 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.215862e-01 | 0.654 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.882390e-01 | 0.540 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.692775e-01 | 0.771 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.692775e-01 | 0.771 |
| R-HSA-391251 | Protein folding | 2.757316e-01 | 0.560 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.185475e-01 | 0.926 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.244335e-01 | 0.905 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.008707e-01 | 0.522 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.673318e-01 | 0.776 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.303884e-01 | 0.885 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.159298e-01 | 0.936 |
| R-HSA-1059683 | Interleukin-6 signaling | 2.622891e-01 | 0.581 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.800176e-01 | 0.745 |
| R-HSA-6794361 | Neurexins and neuroligins | 9.388388e-02 | 1.027 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.800176e-01 | 0.745 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.176984e-01 | 0.929 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.932153e-01 | 0.714 |
| R-HSA-164843 | 2-LTR circle formation | 2.075273e-01 | 0.683 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.353966e-01 | 0.628 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 1.069994e-01 | 0.971 |
| R-HSA-69190 | DNA strand elongation | 1.486236e-01 | 0.828 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.882390e-01 | 0.540 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.188101e-01 | 0.660 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.253514e-01 | 0.647 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 2.622891e-01 | 0.581 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.610494e-01 | 0.793 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.316009e-01 | 0.881 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.353966e-01 | 0.628 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.132791e-01 | 0.504 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.786457e-01 | 0.748 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.548122e-01 | 0.810 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.185475e-01 | 0.926 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 8.493125e-02 | 1.071 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.673318e-01 | 0.776 |
| R-HSA-5205647 | Mitophagy | 1.673318e-01 | 0.776 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 8.555524e-02 | 1.068 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.176984e-01 | 0.929 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.487154e-01 | 0.828 |
| R-HSA-166208 | mTORC1-mediated signalling | 9.030747e-02 | 1.044 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 2.215862e-01 | 0.654 |
| R-HSA-192905 | vRNP Assembly | 2.215862e-01 | 0.654 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.353966e-01 | 0.628 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.353966e-01 | 0.628 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.489628e-01 | 0.604 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.882390e-01 | 0.540 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.673318e-01 | 0.776 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.132791e-01 | 0.504 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.121290e-01 | 0.950 |
| R-HSA-180786 | Extension of Telomeres | 1.197786e-01 | 0.922 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.276153e-01 | 0.894 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.316009e-01 | 0.881 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.460535e-01 | 0.835 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.042906e-01 | 0.517 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.328628e-01 | 0.633 |
| R-HSA-69239 | Synthesis of DNA | 1.661176e-01 | 0.780 |
| R-HSA-6783783 | Interleukin-10 signaling | 2.004602e-01 | 0.698 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.132791e-01 | 0.504 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.132791e-01 | 0.504 |
| R-HSA-9620244 | Long-term potentiation | 1.069994e-01 | 0.971 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.303884e-01 | 0.885 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.869247e-01 | 0.728 |
| R-HSA-157579 | Telomere Maintenance | 3.047443e-01 | 0.516 |
| R-HSA-73894 | DNA Repair | 8.221405e-02 | 1.085 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.593219e-01 | 0.798 |
| R-HSA-448706 | Interleukin-1 processing | 1.932153e-01 | 0.714 |
| R-HSA-9020956 | Interleukin-27 signaling | 2.075273e-01 | 0.683 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.197786e-01 | 0.922 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.928425e-01 | 0.715 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.463865e-02 | 1.072 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.316009e-01 | 0.881 |
| R-HSA-9646399 | Aggrephagy | 2.057813e-01 | 0.687 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.639967e-01 | 0.785 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.548122e-01 | 0.810 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.999348e-01 | 0.699 |
| R-HSA-8981607 | Intracellular oxygen transport | 8.555524e-02 | 1.068 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 8.555524e-02 | 1.068 |
| R-HSA-429593 | Inositol transporters | 1.176984e-01 | 0.929 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.786457e-01 | 0.748 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.932153e-01 | 0.714 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.215862e-01 | 0.654 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.882390e-01 | 0.540 |
| R-HSA-9754706 | Atorvastatin ADME | 3.008707e-01 | 0.522 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.132791e-01 | 0.504 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.276153e-01 | 0.894 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.824678e-01 | 0.739 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.554508e-01 | 0.808 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.127346e-01 | 0.948 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.977284e-01 | 0.526 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.622891e-01 | 0.581 |
| R-HSA-9766229 | Degradation of CDH1 | 8.358479e-02 | 1.078 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.932153e-01 | 0.714 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.932153e-01 | 0.714 |
| R-HSA-622312 | Inflammasomes | 1.244335e-01 | 0.905 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.364077e-01 | 0.865 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.548122e-01 | 0.810 |
| R-HSA-69306 | DNA Replication | 1.937638e-01 | 0.713 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.127346e-01 | 0.948 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.460535e-01 | 0.835 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.470317e-01 | 0.607 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 8.555524e-02 | 1.068 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.017701e-01 | 0.992 |
| R-HSA-8866376 | Reelin signalling pathway | 1.176984e-01 | 0.929 |
| R-HSA-447038 | NrCAM interactions | 1.176984e-01 | 0.929 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 2.075273e-01 | 0.683 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 8.493125e-02 | 1.071 |
| R-HSA-425381 | Bicarbonate transporters | 2.215862e-01 | 0.654 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 2.353966e-01 | 0.628 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.489628e-01 | 0.604 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.622891e-01 | 0.581 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.753798e-01 | 0.560 |
| R-HSA-69481 | G2/M Checkpoints | 1.132955e-01 | 0.946 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.911568e-01 | 0.536 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.902111e-01 | 0.537 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.035898e-01 | 0.985 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.272155e-01 | 0.644 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.548122e-01 | 0.810 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 3.132791e-01 | 0.504 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.738913e-01 | 0.562 |
| R-HSA-1500931 | Cell-Cell communication | 1.515417e-01 | 0.819 |
| R-HSA-1170546 | Prolactin receptor signaling | 2.753798e-01 | 0.560 |
| R-HSA-437239 | Recycling pathway of L1 | 2.582224e-01 | 0.588 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.590411e-01 | 0.798 |
| R-HSA-168249 | Innate Immune System | 9.160361e-02 | 1.038 |
| R-HSA-199991 | Membrane Trafficking | 1.484112e-01 | 0.829 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.333452e-01 | 0.875 |
| R-HSA-447041 | CHL1 interactions | 1.638140e-01 | 0.786 |
| R-HSA-5682910 | LGI-ADAM interactions | 2.215862e-01 | 0.654 |
| R-HSA-8851805 | MET activates RAS signaling | 2.489628e-01 | 0.604 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.622891e-01 | 0.581 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.753798e-01 | 0.560 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.800176e-01 | 0.745 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.736430e-01 | 0.760 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.093150e-01 | 0.679 |
| R-HSA-418990 | Adherens junctions interactions | 2.552291e-01 | 0.593 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.914099e-01 | 0.718 |
| R-HSA-418346 | Platelet homeostasis | 1.627068e-01 | 0.789 |
| R-HSA-1500620 | Meiosis | 2.328628e-01 | 0.633 |
| R-HSA-446728 | Cell junction organization | 2.864622e-01 | 0.543 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.270205e-01 | 0.896 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.661176e-01 | 0.780 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.661176e-01 | 0.780 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.835432e-01 | 0.736 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.622891e-01 | 0.581 |
| R-HSA-2029481 | FCGR activation | 1.149586e-01 | 0.939 |
| R-HSA-1221632 | Meiotic synapsis | 2.977284e-01 | 0.526 |
| R-HSA-8984722 | Interleukin-35 Signalling | 2.489628e-01 | 0.604 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.121290e-01 | 0.950 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.470317e-01 | 0.607 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.805507e-01 | 0.552 |
| R-HSA-168255 | Influenza Infection | 1.466620e-01 | 0.834 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.907041e-01 | 0.720 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.978419e-02 | 1.098 |
| R-HSA-9675135 | Diseases of DNA repair | 2.516343e-01 | 0.599 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.487154e-01 | 0.828 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 9.030747e-02 | 1.044 |
| R-HSA-162592 | Integration of provirus | 2.353966e-01 | 0.628 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.489628e-01 | 0.604 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.753798e-01 | 0.560 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 3.132791e-01 | 0.504 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.316009e-01 | 0.881 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.122859e-01 | 0.673 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.332884e-02 | 1.079 |
| R-HSA-2262752 | Cellular responses to stress | 2.364401e-01 | 0.626 |
| R-HSA-165159 | MTOR signalling | 2.253514e-01 | 0.647 |
| R-HSA-9658195 | Leishmania infection | 9.402051e-02 | 1.027 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.402051e-02 | 1.027 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 1.176984e-01 | 0.929 |
| R-HSA-193144 | Estrogen biosynthesis | 2.489628e-01 | 0.604 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.668587e-01 | 0.574 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.316009e-01 | 0.881 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 2.753798e-01 | 0.560 |
| R-HSA-8876725 | Protein methylation | 2.882390e-01 | 0.540 |
| R-HSA-9733709 | Cardiogenesis | 1.548122e-01 | 0.810 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 1.610494e-01 | 0.793 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 3.008707e-01 | 0.522 |
| R-HSA-8939211 | ESR-mediated signaling | 1.799969e-01 | 0.745 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.692775e-01 | 0.771 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.611272e-01 | 0.793 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 8.493125e-02 | 1.071 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 9.578095e-02 | 1.019 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.328628e-01 | 0.633 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.466326e-01 | 0.608 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.078810e-01 | 0.682 |
| R-HSA-68875 | Mitotic Prophase | 2.200318e-01 | 0.658 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.548019e-01 | 0.594 |
| R-HSA-162587 | HIV Life Cycle | 9.645132e-02 | 1.016 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.127346e-01 | 0.948 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.121290e-01 | 0.950 |
| R-HSA-8854214 | TBC/RABGAPs | 2.319069e-01 | 0.635 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.319069e-01 | 0.635 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 9.388388e-02 | 1.027 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.061676e-01 | 0.974 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.992992e-01 | 0.700 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.416377e-01 | 0.849 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3.008707e-01 | 0.522 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.486236e-01 | 0.828 |
| R-HSA-211000 | Gene Silencing by RNA | 1.661176e-01 | 0.780 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.443560e-01 | 0.841 |
| R-HSA-5357801 | Programmed Cell Death | 2.175608e-01 | 0.662 |
| R-HSA-75153 | Apoptotic execution phase | 2.516343e-01 | 0.599 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.911568e-01 | 0.536 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.163210e-01 | 0.500 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.173800e-01 | 0.498 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.173800e-01 | 0.498 |
| R-HSA-5578775 | Ion homeostasis | 3.173800e-01 | 0.498 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.173892e-01 | 0.498 |
| R-HSA-70171 | Glycolysis | 3.193082e-01 | 0.496 |
| R-HSA-5621480 | Dectin-2 family | 3.239039e-01 | 0.490 |
| R-HSA-1483166 | Synthesis of PA | 3.239039e-01 | 0.490 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.254679e-01 | 0.487 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.254679e-01 | 0.487 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.254679e-01 | 0.487 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.254679e-01 | 0.487 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.254679e-01 | 0.487 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.254679e-01 | 0.487 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 3.254679e-01 | 0.487 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.254679e-01 | 0.487 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.254679e-01 | 0.487 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.254679e-01 | 0.487 |
| R-HSA-1483255 | PI Metabolism | 3.290236e-01 | 0.483 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.304118e-01 | 0.481 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.369023e-01 | 0.472 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.369023e-01 | 0.472 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.374412e-01 | 0.472 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.374412e-01 | 0.472 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.374412e-01 | 0.472 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.374412e-01 | 0.472 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.374412e-01 | 0.472 |
| R-HSA-163615 | PKA activation | 3.374412e-01 | 0.472 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 3.374412e-01 | 0.472 |
| R-HSA-180292 | GAB1 signalosome | 3.374412e-01 | 0.472 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.374412e-01 | 0.472 |
| R-HSA-5358508 | Mismatch Repair | 3.374412e-01 | 0.472 |
| R-HSA-9609690 | HCMV Early Events | 3.407537e-01 | 0.468 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.407537e-01 | 0.468 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.411522e-01 | 0.467 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.417335e-01 | 0.466 |
| R-HSA-69242 | S Phase | 3.457598e-01 | 0.461 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.484412e-01 | 0.458 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.492026e-01 | 0.457 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.492026e-01 | 0.457 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.492026e-01 | 0.457 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.492026e-01 | 0.457 |
| R-HSA-449836 | Other interleukin signaling | 3.492026e-01 | 0.457 |
| R-HSA-1442490 | Collagen degradation | 3.498254e-01 | 0.456 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.532886e-01 | 0.452 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.547958e-01 | 0.450 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.562553e-01 | 0.448 |
| R-HSA-9707616 | Heme signaling | 3.562553e-01 | 0.448 |
| R-HSA-421270 | Cell-cell junction organization | 3.569460e-01 | 0.447 |
| R-HSA-1280218 | Adaptive Immune System | 3.572254e-01 | 0.447 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.607560e-01 | 0.443 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.607560e-01 | 0.443 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.607560e-01 | 0.443 |
| R-HSA-445144 | Signal transduction by L1 | 3.607560e-01 | 0.443 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.607560e-01 | 0.443 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.626624e-01 | 0.440 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.626624e-01 | 0.440 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.629697e-01 | 0.440 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.653449e-01 | 0.437 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.690454e-01 | 0.433 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.690454e-01 | 0.433 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.721050e-01 | 0.429 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.721050e-01 | 0.429 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.721050e-01 | 0.429 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.721050e-01 | 0.429 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 3.721050e-01 | 0.429 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.721050e-01 | 0.429 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.721050e-01 | 0.429 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.726283e-01 | 0.429 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.726283e-01 | 0.429 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.754034e-01 | 0.426 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.832532e-01 | 0.417 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 3.832532e-01 | 0.417 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.832532e-01 | 0.417 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.880393e-01 | 0.411 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.942041e-01 | 0.404 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.942041e-01 | 0.404 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.942041e-01 | 0.404 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.942041e-01 | 0.404 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.942041e-01 | 0.404 |
| R-HSA-5218859 | Regulated Necrosis | 3.943152e-01 | 0.404 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.005111e-01 | 0.397 |
| R-HSA-397014 | Muscle contraction | 4.005111e-01 | 0.397 |
| R-HSA-109581 | Apoptosis | 4.020413e-01 | 0.396 |
| R-HSA-8854691 | Interleukin-20 family signaling | 4.049612e-01 | 0.393 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.049612e-01 | 0.393 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.049612e-01 | 0.393 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.049612e-01 | 0.393 |
| R-HSA-9018682 | Biosynthesis of maresins | 4.049612e-01 | 0.393 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.049612e-01 | 0.393 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.067780e-01 | 0.391 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.067780e-01 | 0.391 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.109359e-01 | 0.386 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.109359e-01 | 0.386 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.129632e-01 | 0.384 |
| R-HSA-6783589 | Interleukin-6 family signaling | 4.155280e-01 | 0.381 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.155280e-01 | 0.381 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.155280e-01 | 0.381 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.155280e-01 | 0.381 |
| R-HSA-70326 | Glucose metabolism | 4.156778e-01 | 0.381 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.252366e-01 | 0.371 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 4.259078e-01 | 0.371 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 4.259078e-01 | 0.371 |
| R-HSA-1296059 | G protein gated Potassium channels | 4.259078e-01 | 0.371 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.259078e-01 | 0.371 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.259078e-01 | 0.371 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.259078e-01 | 0.371 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.259078e-01 | 0.371 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.361038e-01 | 0.360 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.361038e-01 | 0.360 |
| R-HSA-525793 | Myogenesis | 4.361038e-01 | 0.360 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.361038e-01 | 0.360 |
| R-HSA-3295583 | TRP channels | 4.361038e-01 | 0.360 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 4.361038e-01 | 0.360 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.361038e-01 | 0.360 |
| R-HSA-8852135 | Protein ubiquitination | 4.373756e-01 | 0.359 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.378090e-01 | 0.359 |
| R-HSA-72306 | tRNA processing | 4.378090e-01 | 0.359 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.433929e-01 | 0.353 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.438549e-01 | 0.353 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.461194e-01 | 0.351 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.461194e-01 | 0.351 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.461194e-01 | 0.351 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.461194e-01 | 0.351 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.461194e-01 | 0.351 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.461194e-01 | 0.351 |
| R-HSA-264876 | Insulin processing | 4.461194e-01 | 0.351 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.461194e-01 | 0.351 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 4.461194e-01 | 0.351 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.496035e-01 | 0.347 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.496035e-01 | 0.347 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.496035e-01 | 0.347 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.496035e-01 | 0.347 |
| R-HSA-597592 | Post-translational protein modification | 4.551496e-01 | 0.342 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.553199e-01 | 0.342 |
| R-HSA-9679506 | SARS-CoV Infections | 4.553246e-01 | 0.342 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 4.559577e-01 | 0.341 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.559577e-01 | 0.341 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.559577e-01 | 0.341 |
| R-HSA-77387 | Insulin receptor recycling | 4.559577e-01 | 0.341 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.559577e-01 | 0.341 |
| R-HSA-73614 | Pyrimidine salvage | 4.559577e-01 | 0.341 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.559577e-01 | 0.341 |
| R-HSA-9757110 | Prednisone ADME | 4.559577e-01 | 0.341 |
| R-HSA-5620971 | Pyroptosis | 4.559577e-01 | 0.341 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.574235e-01 | 0.340 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.612283e-01 | 0.336 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.656219e-01 | 0.332 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.656219e-01 | 0.332 |
| R-HSA-72086 | mRNA Capping | 4.656219e-01 | 0.332 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.656219e-01 | 0.332 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.656219e-01 | 0.332 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.670993e-01 | 0.331 |
| R-HSA-6806834 | Signaling by MET | 4.670993e-01 | 0.331 |
| R-HSA-72312 | rRNA processing | 4.699795e-01 | 0.328 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.751149e-01 | 0.323 |
| R-HSA-2424491 | DAP12 signaling | 4.751149e-01 | 0.323 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.751149e-01 | 0.323 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.751149e-01 | 0.323 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.751149e-01 | 0.323 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.751149e-01 | 0.323 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.751149e-01 | 0.323 |
| R-HSA-2559583 | Cellular Senescence | 4.768054e-01 | 0.322 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.787267e-01 | 0.320 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.844399e-01 | 0.315 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.844399e-01 | 0.315 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.844399e-01 | 0.315 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.844821e-01 | 0.315 |
| R-HSA-1474165 | Reproduction | 4.850729e-01 | 0.314 |
| R-HSA-9824446 | Viral Infection Pathways | 4.897703e-01 | 0.310 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.935998e-01 | 0.307 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 4.935998e-01 | 0.307 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.935998e-01 | 0.307 |
| R-HSA-1483257 | Phospholipid metabolism | 4.949116e-01 | 0.305 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.958744e-01 | 0.305 |
| R-HSA-157118 | Signaling by NOTCH | 4.971087e-01 | 0.304 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.015104e-01 | 0.300 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.025975e-01 | 0.299 |
| R-HSA-9930044 | Nuclear RNA decay | 5.025975e-01 | 0.299 |
| R-HSA-397795 | G-protein beta:gamma signalling | 5.025975e-01 | 0.299 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.025975e-01 | 0.299 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.025975e-01 | 0.299 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.025975e-01 | 0.299 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.025975e-01 | 0.299 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.025975e-01 | 0.299 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.071058e-01 | 0.295 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.071058e-01 | 0.295 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.072468e-01 | 0.295 |
| R-HSA-390522 | Striated Muscle Contraction | 5.114359e-01 | 0.291 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.114359e-01 | 0.291 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.114359e-01 | 0.291 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.114359e-01 | 0.291 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.114359e-01 | 0.291 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.184597e-01 | 0.285 |
| R-HSA-203615 | eNOS activation | 5.201178e-01 | 0.284 |
| R-HSA-190861 | Gap junction assembly | 5.201178e-01 | 0.284 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.201178e-01 | 0.284 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 5.201178e-01 | 0.284 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.247796e-01 | 0.280 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.286459e-01 | 0.277 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.286459e-01 | 0.277 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.286459e-01 | 0.277 |
| R-HSA-381042 | PERK regulates gene expression | 5.286459e-01 | 0.277 |
| R-HSA-73884 | Base Excision Repair | 5.290752e-01 | 0.276 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.290880e-01 | 0.276 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.292499e-01 | 0.276 |
| R-HSA-9609646 | HCMV Infection | 5.302618e-01 | 0.276 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.344632e-01 | 0.272 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.370230e-01 | 0.270 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.370230e-01 | 0.270 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 5.370230e-01 | 0.270 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.370230e-01 | 0.270 |
| R-HSA-163560 | Triglyceride catabolism | 5.370230e-01 | 0.270 |
| R-HSA-111933 | Calmodulin induced events | 5.370230e-01 | 0.270 |
| R-HSA-111997 | CaM pathway | 5.370230e-01 | 0.270 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.370230e-01 | 0.270 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.398089e-01 | 0.268 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.452517e-01 | 0.263 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.452517e-01 | 0.263 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.452517e-01 | 0.263 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.452517e-01 | 0.263 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 5.533346e-01 | 0.257 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.533346e-01 | 0.257 |
| R-HSA-74217 | Purine salvage | 5.533346e-01 | 0.257 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.533346e-01 | 0.257 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.533346e-01 | 0.257 |
| R-HSA-1474290 | Collagen formation | 5.555906e-01 | 0.255 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.585079e-01 | 0.253 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.612744e-01 | 0.251 |
| R-HSA-71336 | Pentose phosphate pathway | 5.612744e-01 | 0.251 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.612744e-01 | 0.251 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.612744e-01 | 0.251 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.690735e-01 | 0.245 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.690735e-01 | 0.245 |
| R-HSA-5260271 | Diseases of Immune System | 5.690735e-01 | 0.245 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 5.690735e-01 | 0.245 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.709401e-01 | 0.243 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.709861e-01 | 0.243 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.709861e-01 | 0.243 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.760316e-01 | 0.240 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.767345e-01 | 0.239 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.767345e-01 | 0.239 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.767345e-01 | 0.239 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 5.767345e-01 | 0.239 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.767345e-01 | 0.239 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.767345e-01 | 0.239 |
| R-HSA-9607240 | FLT3 Signaling | 5.767345e-01 | 0.239 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.775949e-01 | 0.238 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.810338e-01 | 0.236 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.842597e-01 | 0.233 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.842597e-01 | 0.233 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.909080e-01 | 0.228 |
| R-HSA-977444 | GABA B receptor activation | 5.916516e-01 | 0.228 |
| R-HSA-991365 | Activation of GABAB receptors | 5.916516e-01 | 0.228 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.916516e-01 | 0.228 |
| R-HSA-111996 | Ca-dependent events | 5.916516e-01 | 0.228 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.957800e-01 | 0.225 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.060447e-01 | 0.217 |
| R-HSA-2172127 | DAP12 interactions | 6.060447e-01 | 0.217 |
| R-HSA-373752 | Netrin-1 signaling | 6.060447e-01 | 0.217 |
| R-HSA-190828 | Gap junction trafficking | 6.060447e-01 | 0.217 |
| R-HSA-5683826 | Surfactant metabolism | 6.060447e-01 | 0.217 |
| R-HSA-69236 | G1 Phase | 6.060447e-01 | 0.217 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.060447e-01 | 0.217 |
| R-HSA-9610379 | HCMV Late Events | 6.065866e-01 | 0.217 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.130506e-01 | 0.213 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.130506e-01 | 0.213 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.130506e-01 | 0.213 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.130506e-01 | 0.213 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.130506e-01 | 0.213 |
| R-HSA-392499 | Metabolism of proteins | 6.199266e-01 | 0.208 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.199322e-01 | 0.208 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.199322e-01 | 0.208 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.199322e-01 | 0.208 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.266920e-01 | 0.203 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.266920e-01 | 0.203 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.266920e-01 | 0.203 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.331939e-01 | 0.198 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.331939e-01 | 0.198 |
| R-HSA-5620924 | Intraflagellar transport | 6.333318e-01 | 0.198 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.376761e-01 | 0.195 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.376761e-01 | 0.195 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.398540e-01 | 0.194 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.398540e-01 | 0.194 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 6.398540e-01 | 0.194 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.398540e-01 | 0.194 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.398540e-01 | 0.194 |
| R-HSA-5619102 | SLC transporter disorders | 6.438313e-01 | 0.191 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.462606e-01 | 0.190 |
| R-HSA-112316 | Neuronal System | 6.488254e-01 | 0.188 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.508654e-01 | 0.187 |
| R-HSA-9864848 | Complex IV assembly | 6.525536e-01 | 0.185 |
| R-HSA-912446 | Meiotic recombination | 6.525536e-01 | 0.185 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.525536e-01 | 0.185 |
| R-HSA-2514856 | The phototransduction cascade | 6.525536e-01 | 0.185 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.551765e-01 | 0.184 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.587351e-01 | 0.181 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.587351e-01 | 0.181 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.594451e-01 | 0.181 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.636714e-01 | 0.178 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.648069e-01 | 0.177 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.648069e-01 | 0.177 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.678555e-01 | 0.175 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.719977e-01 | 0.173 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.719977e-01 | 0.173 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.751741e-01 | 0.171 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.766295e-01 | 0.170 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.801566e-01 | 0.167 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.801566e-01 | 0.167 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.823840e-01 | 0.166 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.823840e-01 | 0.166 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.823840e-01 | 0.166 |
| R-HSA-75893 | TNF signaling | 6.823840e-01 | 0.166 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.823840e-01 | 0.166 |
| R-HSA-177929 | Signaling by EGFR | 6.823840e-01 | 0.166 |
| R-HSA-109582 | Hemostasis | 6.852082e-01 | 0.164 |
| R-HSA-8979227 | Triglyceride metabolism | 6.990424e-01 | 0.155 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.012946e-01 | 0.154 |
| R-HSA-977443 | GABA receptor activation | 7.043994e-01 | 0.152 |
| R-HSA-379724 | tRNA Aminoacylation | 7.043994e-01 | 0.152 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 7.096613e-01 | 0.149 |
| R-HSA-8956321 | Nucleotide salvage | 7.096613e-01 | 0.149 |
| R-HSA-450294 | MAP kinase activation | 7.096613e-01 | 0.149 |
| R-HSA-112043 | PLC beta mediated events | 7.096613e-01 | 0.149 |
| R-HSA-1268020 | Mitochondrial protein import | 7.148300e-01 | 0.146 |
| R-HSA-69206 | G1/S Transition | 7.148415e-01 | 0.146 |
| R-HSA-5663205 | Infectious disease | 7.189702e-01 | 0.143 |
| R-HSA-983712 | Ion channel transport | 7.198186e-01 | 0.143 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.199069e-01 | 0.143 |
| R-HSA-8848021 | Signaling by PTK6 | 7.199069e-01 | 0.143 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.248937e-01 | 0.140 |
| R-HSA-211981 | Xenobiotics | 7.248937e-01 | 0.140 |
| R-HSA-2428924 | IGF1R signaling cascade | 7.248937e-01 | 0.140 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.297921e-01 | 0.137 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 7.297921e-01 | 0.137 |
| R-HSA-112040 | G-protein mediated events | 7.393296e-01 | 0.131 |
| R-HSA-196071 | Metabolism of steroid hormones | 7.393296e-01 | 0.131 |
| R-HSA-5576891 | Cardiac conduction | 7.395955e-01 | 0.131 |
| R-HSA-9843745 | Adipogenesis | 7.395955e-01 | 0.131 |
| R-HSA-9909396 | Circadian clock | 7.429784e-01 | 0.129 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.429784e-01 | 0.129 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.439718e-01 | 0.128 |
| R-HSA-913709 | O-linked glycosylation of mucins | 7.439718e-01 | 0.128 |
| R-HSA-167172 | Transcription of the HIV genome | 7.439718e-01 | 0.128 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.530104e-01 | 0.123 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.530104e-01 | 0.123 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.530104e-01 | 0.123 |
| R-HSA-448424 | Interleukin-17 signaling | 7.530104e-01 | 0.123 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.574098e-01 | 0.121 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.574098e-01 | 0.121 |
| R-HSA-8978934 | Metabolism of cofactors | 7.574098e-01 | 0.121 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.574098e-01 | 0.121 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.580719e-01 | 0.120 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.595649e-01 | 0.119 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.617311e-01 | 0.118 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 7.617311e-01 | 0.118 |
| R-HSA-9749641 | Aspirin ADME | 7.659756e-01 | 0.116 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.659756e-01 | 0.116 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.659756e-01 | 0.116 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.701448e-01 | 0.113 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.701448e-01 | 0.113 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.701448e-01 | 0.113 |
| R-HSA-5689603 | UCH proteinases | 7.782625e-01 | 0.109 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.782625e-01 | 0.109 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.809003e-01 | 0.107 |
| R-HSA-4086400 | PCP/CE pathway | 7.860944e-01 | 0.105 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.860944e-01 | 0.105 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.860944e-01 | 0.105 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.865170e-01 | 0.104 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.875044e-01 | 0.104 |
| R-HSA-9659379 | Sensory processing of sound | 7.899063e-01 | 0.102 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.936506e-01 | 0.100 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.936506e-01 | 0.100 |
| R-HSA-977225 | Amyloid fiber formation | 7.973284e-01 | 0.098 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.973284e-01 | 0.098 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 7.973284e-01 | 0.098 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.031088e-01 | 0.095 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 8.044890e-01 | 0.094 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.057604e-01 | 0.094 |
| R-HSA-9609507 | Protein localization | 8.109688e-01 | 0.091 |
| R-HSA-73887 | Death Receptor Signaling | 8.135262e-01 | 0.090 |
| R-HSA-1989781 | PPARA activates gene expression | 8.160527e-01 | 0.088 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.180628e-01 | 0.087 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.210143e-01 | 0.086 |
| R-HSA-70268 | Pyruvate metabolism | 8.213069e-01 | 0.085 |
| R-HSA-195721 | Signaling by WNT | 8.214221e-01 | 0.085 |
| R-HSA-156902 | Peptide chain elongation | 8.244933e-01 | 0.084 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 8.244933e-01 | 0.084 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.244933e-01 | 0.084 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.282323e-01 | 0.082 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.282323e-01 | 0.082 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.306973e-01 | 0.081 |
| R-HSA-202424 | Downstream TCR signaling | 8.306973e-01 | 0.081 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.337168e-01 | 0.079 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.391980e-01 | 0.076 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.395958e-01 | 0.076 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.395958e-01 | 0.076 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.424572e-01 | 0.074 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.452677e-01 | 0.073 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.452677e-01 | 0.073 |
| R-HSA-1266738 | Developmental Biology | 8.477969e-01 | 0.072 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.480282e-01 | 0.072 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.507396e-01 | 0.070 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.507396e-01 | 0.070 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.507396e-01 | 0.070 |
| R-HSA-1296071 | Potassium Channels | 8.534028e-01 | 0.069 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.534028e-01 | 0.069 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.565761e-01 | 0.067 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.573212e-01 | 0.067 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.585881e-01 | 0.066 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.585881e-01 | 0.066 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.585881e-01 | 0.066 |
| R-HSA-190236 | Signaling by FGFR | 8.585881e-01 | 0.066 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.611117e-01 | 0.065 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.611117e-01 | 0.065 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.660252e-01 | 0.062 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.660252e-01 | 0.062 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.684166e-01 | 0.061 |
| R-HSA-192823 | Viral mRNA Translation | 8.707654e-01 | 0.060 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.730725e-01 | 0.059 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.730725e-01 | 0.059 |
| R-HSA-111885 | Opioid Signalling | 8.730725e-01 | 0.059 |
| R-HSA-9833110 | RSV-host interactions | 8.753385e-01 | 0.058 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.818975e-01 | 0.055 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.840064e-01 | 0.054 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.840064e-01 | 0.054 |
| R-HSA-6803157 | Antimicrobial peptides | 8.901108e-01 | 0.051 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.976205e-01 | 0.047 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.995816e-01 | 0.046 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.013758e-01 | 0.045 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.036806e-01 | 0.044 |
| R-HSA-1592230 | Mitochondrial biogenesis | 9.048689e-01 | 0.043 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.065690e-01 | 0.043 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.074273e-01 | 0.042 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.082387e-01 | 0.042 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.082387e-01 | 0.042 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 9.082387e-01 | 0.042 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 9.114896e-01 | 0.040 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.130717e-01 | 0.039 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.130717e-01 | 0.039 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.146256e-01 | 0.039 |
| R-HSA-114608 | Platelet degranulation | 9.219897e-01 | 0.035 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.261007e-01 | 0.033 |
| R-HSA-8951664 | Neddylation | 9.301172e-01 | 0.031 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.312481e-01 | 0.031 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 9.360381e-01 | 0.029 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.365466e-01 | 0.028 |
| R-HSA-5173105 | O-linked glycosylation | 9.371827e-01 | 0.028 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.383068e-01 | 0.028 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.422022e-01 | 0.026 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.446431e-01 | 0.025 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.455650e-01 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 9.462810e-01 | 0.024 |
| R-HSA-2187338 | Visual phototransduction | 9.485027e-01 | 0.023 |
| R-HSA-382551 | Transport of small molecules | 9.485893e-01 | 0.023 |
| R-HSA-166520 | Signaling by NTRKs | 9.494249e-01 | 0.023 |
| R-HSA-1474244 | Extracellular matrix organization | 9.510536e-01 | 0.022 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.512203e-01 | 0.022 |
| R-HSA-1643685 | Disease | 9.513398e-01 | 0.022 |
| R-HSA-2142753 | Arachidonate metabolism | 9.529521e-01 | 0.021 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.573908e-01 | 0.019 |
| R-HSA-9711097 | Cellular response to starvation | 9.577886e-01 | 0.019 |
| R-HSA-877300 | Interferon gamma signaling | 9.585450e-01 | 0.018 |
| R-HSA-72766 | Translation | 9.609318e-01 | 0.017 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.621294e-01 | 0.017 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.641300e-01 | 0.016 |
| R-HSA-74160 | Gene expression (Transcription) | 9.690345e-01 | 0.014 |
| R-HSA-611105 | Respiratory electron transport | 9.711328e-01 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.718365e-01 | 0.012 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.750264e-01 | 0.011 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.762521e-01 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.784645e-01 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 9.830511e-01 | 0.007 |
| R-HSA-9748784 | Drug ADME | 9.862727e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.884315e-01 | 0.005 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.887583e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.889040e-01 | 0.005 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.889606e-01 | 0.005 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.890783e-01 | 0.005 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.897345e-01 | 0.004 |
| R-HSA-15869 | Metabolism of nucleotides | 9.901009e-01 | 0.004 |
| R-HSA-4839726 | Chromatin organization | 9.921847e-01 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.923045e-01 | 0.003 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.939423e-01 | 0.003 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.963860e-01 | 0.002 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.966189e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.987348e-01 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 9.992399e-01 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.994576e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.995728e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996100e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997387e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.998175e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999914e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.891 | 0.104 | 2 | 0.898 |
CDC7 |
0.883 | 0.058 | 1 | 0.852 |
CAMK1B |
0.880 | 0.146 | -3 | 0.878 |
DSTYK |
0.879 | 0.064 | 2 | 0.901 |
CLK3 |
0.879 | 0.164 | 1 | 0.839 |
PRKD1 |
0.878 | 0.207 | -3 | 0.823 |
MOS |
0.877 | 0.055 | 1 | 0.873 |
PRPK |
0.877 | -0.116 | -1 | 0.881 |
RAF1 |
0.877 | 0.002 | 1 | 0.873 |
IKKB |
0.876 | -0.043 | -2 | 0.799 |
PRKD2 |
0.876 | 0.199 | -3 | 0.793 |
PIM3 |
0.875 | 0.045 | -3 | 0.839 |
GCN2 |
0.874 | -0.124 | 2 | 0.825 |
CAMK2G |
0.874 | -0.006 | 2 | 0.846 |
ATR |
0.873 | 0.065 | 1 | 0.882 |
RSK2 |
0.873 | 0.117 | -3 | 0.784 |
TBK1 |
0.873 | -0.038 | 1 | 0.780 |
NUAK2 |
0.873 | 0.125 | -3 | 0.862 |
NLK |
0.872 | 0.029 | 1 | 0.839 |
MTOR |
0.872 | -0.101 | 1 | 0.801 |
BMPR2 |
0.872 | -0.058 | -2 | 0.922 |
NDR2 |
0.872 | 0.019 | -3 | 0.849 |
TSSK2 |
0.872 | 0.249 | -5 | 0.901 |
NEK6 |
0.872 | 0.032 | -2 | 0.908 |
WNK1 |
0.871 | 0.098 | -2 | 0.893 |
PDHK4 |
0.871 | -0.216 | 1 | 0.873 |
ULK2 |
0.871 | -0.115 | 2 | 0.813 |
TSSK1 |
0.871 | 0.243 | -3 | 0.887 |
PKN3 |
0.870 | 0.059 | -3 | 0.837 |
NEK7 |
0.870 | -0.032 | -3 | 0.858 |
IKKE |
0.870 | -0.049 | 1 | 0.781 |
MAPKAPK2 |
0.870 | 0.128 | -3 | 0.747 |
MARK4 |
0.870 | 0.082 | 4 | 0.887 |
MAPKAPK3 |
0.870 | 0.100 | -3 | 0.796 |
NIK |
0.869 | 0.080 | -3 | 0.898 |
CDKL1 |
0.869 | 0.032 | -3 | 0.801 |
TGFBR2 |
0.869 | 0.042 | -2 | 0.853 |
MST4 |
0.869 | 0.076 | 2 | 0.883 |
AMPKA1 |
0.868 | 0.129 | -3 | 0.872 |
PDHK1 |
0.868 | -0.123 | 1 | 0.875 |
GRK6 |
0.868 | 0.075 | 1 | 0.860 |
CAMLCK |
0.868 | 0.081 | -2 | 0.903 |
SKMLCK |
0.867 | 0.089 | -2 | 0.896 |
NDR1 |
0.867 | 0.026 | -3 | 0.851 |
DAPK2 |
0.867 | 0.090 | -3 | 0.880 |
PIM1 |
0.867 | 0.103 | -3 | 0.797 |
PKN2 |
0.866 | 0.081 | -3 | 0.857 |
ERK5 |
0.866 | 0.011 | 1 | 0.802 |
IKKA |
0.866 | 0.017 | -2 | 0.784 |
P90RSK |
0.865 | 0.056 | -3 | 0.784 |
CAMK2D |
0.865 | 0.051 | -3 | 0.857 |
P70S6KB |
0.865 | 0.062 | -3 | 0.821 |
CAMK2B |
0.864 | 0.130 | 2 | 0.814 |
GRK5 |
0.864 | -0.105 | -3 | 0.851 |
HUNK |
0.864 | -0.056 | 2 | 0.842 |
ATM |
0.863 | 0.088 | 1 | 0.831 |
RSK3 |
0.863 | 0.047 | -3 | 0.778 |
CDKL5 |
0.863 | 0.031 | -3 | 0.790 |
PRKD3 |
0.863 | 0.164 | -3 | 0.766 |
PKCD |
0.863 | 0.072 | 2 | 0.811 |
BMPR1B |
0.863 | 0.167 | 1 | 0.805 |
RIPK3 |
0.863 | -0.062 | 3 | 0.749 |
SRPK1 |
0.862 | 0.059 | -3 | 0.747 |
MLK1 |
0.862 | -0.091 | 2 | 0.835 |
AMPKA2 |
0.862 | 0.112 | -3 | 0.844 |
WNK3 |
0.862 | -0.112 | 1 | 0.843 |
LATS2 |
0.862 | 0.010 | -5 | 0.740 |
GRK1 |
0.862 | 0.031 | -2 | 0.804 |
PKACG |
0.862 | 0.071 | -2 | 0.790 |
FAM20C |
0.862 | 0.093 | 2 | 0.643 |
HIPK4 |
0.861 | 0.031 | 1 | 0.803 |
ULK1 |
0.861 | -0.148 | -3 | 0.834 |
AURC |
0.861 | 0.140 | -2 | 0.721 |
CAMK4 |
0.860 | 0.064 | -3 | 0.852 |
PLK1 |
0.859 | 0.058 | -2 | 0.861 |
ICK |
0.859 | 0.024 | -3 | 0.834 |
KIS |
0.859 | 0.025 | 1 | 0.698 |
NEK9 |
0.859 | -0.093 | 2 | 0.859 |
CAMK2A |
0.859 | 0.104 | 2 | 0.820 |
ALK4 |
0.859 | 0.075 | -2 | 0.870 |
TGFBR1 |
0.858 | 0.103 | -2 | 0.839 |
SRPK2 |
0.858 | 0.061 | -3 | 0.680 |
QSK |
0.858 | 0.097 | 4 | 0.868 |
BCKDK |
0.858 | -0.142 | -1 | 0.804 |
CHK1 |
0.857 | 0.179 | -3 | 0.852 |
CHAK2 |
0.857 | -0.085 | -1 | 0.854 |
GRK4 |
0.857 | -0.081 | -2 | 0.853 |
MELK |
0.857 | 0.088 | -3 | 0.834 |
SIK |
0.857 | 0.099 | -3 | 0.798 |
NUAK1 |
0.857 | 0.074 | -3 | 0.824 |
PAK1 |
0.856 | 0.059 | -2 | 0.829 |
PAK6 |
0.856 | 0.151 | -2 | 0.777 |
QIK |
0.856 | 0.044 | -3 | 0.859 |
NIM1 |
0.856 | -0.031 | 3 | 0.799 |
MARK3 |
0.856 | 0.114 | 4 | 0.835 |
CLK4 |
0.856 | 0.116 | -3 | 0.791 |
DLK |
0.855 | -0.128 | 1 | 0.858 |
ANKRD3 |
0.855 | -0.098 | 1 | 0.880 |
MNK2 |
0.855 | 0.101 | -2 | 0.839 |
PKR |
0.855 | 0.045 | 1 | 0.863 |
AURB |
0.855 | 0.124 | -2 | 0.720 |
CLK1 |
0.855 | 0.130 | -3 | 0.773 |
MARK2 |
0.855 | 0.105 | 4 | 0.802 |
RSK4 |
0.855 | 0.088 | -3 | 0.752 |
MSK2 |
0.855 | 0.024 | -3 | 0.745 |
LATS1 |
0.854 | 0.064 | -3 | 0.862 |
ACVR2A |
0.854 | 0.108 | -2 | 0.849 |
SRPK3 |
0.854 | 0.044 | -3 | 0.723 |
CDK8 |
0.854 | -0.005 | 1 | 0.672 |
GRK7 |
0.854 | 0.086 | 1 | 0.787 |
PKACB |
0.853 | 0.127 | -2 | 0.732 |
TTBK2 |
0.853 | -0.148 | 2 | 0.747 |
ACVR2B |
0.853 | 0.093 | -2 | 0.857 |
BRSK1 |
0.852 | 0.038 | -3 | 0.818 |
PAK3 |
0.852 | 0.007 | -2 | 0.830 |
MYLK4 |
0.852 | 0.089 | -2 | 0.826 |
ALK2 |
0.852 | 0.089 | -2 | 0.851 |
MSK1 |
0.852 | 0.080 | -3 | 0.754 |
RIPK1 |
0.851 | -0.159 | 1 | 0.828 |
MASTL |
0.851 | -0.306 | -2 | 0.843 |
MARK1 |
0.851 | 0.088 | 4 | 0.852 |
PRKX |
0.851 | 0.154 | -3 | 0.708 |
AURA |
0.851 | 0.111 | -2 | 0.697 |
IRE1 |
0.851 | -0.083 | 1 | 0.810 |
PLK3 |
0.851 | 0.013 | 2 | 0.807 |
DYRK2 |
0.851 | 0.033 | 1 | 0.704 |
DNAPK |
0.850 | 0.094 | 1 | 0.783 |
NEK2 |
0.849 | -0.045 | 2 | 0.832 |
PKG2 |
0.849 | 0.093 | -2 | 0.732 |
MLK3 |
0.849 | -0.061 | 2 | 0.764 |
CAMK1G |
0.849 | 0.064 | -3 | 0.790 |
MLK2 |
0.848 | -0.178 | 2 | 0.832 |
AKT2 |
0.848 | 0.086 | -3 | 0.709 |
PKCA |
0.848 | 0.025 | 2 | 0.751 |
JNK2 |
0.848 | 0.070 | 1 | 0.622 |
MNK1 |
0.848 | 0.083 | -2 | 0.848 |
MEK1 |
0.848 | -0.123 | 2 | 0.855 |
BMPR1A |
0.848 | 0.142 | 1 | 0.785 |
CLK2 |
0.848 | 0.141 | -3 | 0.767 |
SGK3 |
0.848 | 0.079 | -3 | 0.774 |
TLK2 |
0.848 | -0.009 | 1 | 0.852 |
PKCG |
0.847 | -0.007 | 2 | 0.762 |
PAK2 |
0.847 | 0.010 | -2 | 0.818 |
BRSK2 |
0.847 | -0.009 | -3 | 0.846 |
PKCB |
0.847 | 0.002 | 2 | 0.757 |
IRE2 |
0.847 | -0.060 | 2 | 0.777 |
YSK4 |
0.847 | -0.101 | 1 | 0.810 |
SMG1 |
0.846 | -0.010 | 1 | 0.840 |
JNK3 |
0.846 | 0.036 | 1 | 0.655 |
PHKG1 |
0.846 | -0.025 | -3 | 0.852 |
CDK19 |
0.846 | -0.011 | 1 | 0.630 |
PIM2 |
0.845 | 0.050 | -3 | 0.766 |
VRK2 |
0.845 | -0.222 | 1 | 0.882 |
MLK4 |
0.844 | -0.075 | 2 | 0.745 |
PKCH |
0.844 | -0.009 | 2 | 0.745 |
MAPKAPK5 |
0.844 | -0.062 | -3 | 0.735 |
DCAMKL1 |
0.844 | 0.056 | -3 | 0.818 |
P38A |
0.843 | 0.028 | 1 | 0.703 |
SSTK |
0.843 | 0.110 | 4 | 0.857 |
BRAF |
0.843 | -0.031 | -4 | 0.789 |
CDK1 |
0.843 | 0.016 | 1 | 0.636 |
PERK |
0.843 | -0.056 | -2 | 0.887 |
CAMK1D |
0.843 | 0.125 | -3 | 0.720 |
GRK2 |
0.843 | -0.018 | -2 | 0.752 |
DRAK1 |
0.843 | -0.026 | 1 | 0.790 |
CDK7 |
0.842 | -0.035 | 1 | 0.676 |
HRI |
0.842 | -0.088 | -2 | 0.902 |
WNK4 |
0.841 | -0.025 | -2 | 0.887 |
TLK1 |
0.840 | -0.031 | -2 | 0.869 |
PINK1 |
0.840 | -0.111 | 1 | 0.838 |
SMMLCK |
0.840 | 0.053 | -3 | 0.830 |
CDK5 |
0.840 | 0.004 | 1 | 0.695 |
HIPK1 |
0.840 | 0.051 | 1 | 0.718 |
AKT1 |
0.840 | 0.101 | -3 | 0.731 |
SNRK |
0.840 | -0.139 | 2 | 0.722 |
PKCZ |
0.840 | -0.057 | 2 | 0.800 |
PKACA |
0.840 | 0.108 | -2 | 0.687 |
CDK13 |
0.839 | -0.032 | 1 | 0.647 |
CHAK1 |
0.839 | -0.164 | 2 | 0.781 |
P38B |
0.839 | 0.030 | 1 | 0.635 |
PHKG2 |
0.838 | 0.035 | -3 | 0.838 |
DCAMKL2 |
0.838 | 0.038 | -3 | 0.846 |
CDK2 |
0.838 | -0.032 | 1 | 0.724 |
CDK18 |
0.838 | 0.017 | 1 | 0.604 |
PLK4 |
0.838 | -0.107 | 2 | 0.680 |
MEKK3 |
0.838 | -0.135 | 1 | 0.832 |
P70S6K |
0.838 | 0.012 | -3 | 0.730 |
PRP4 |
0.837 | 0.000 | -3 | 0.754 |
HIPK2 |
0.837 | 0.047 | 1 | 0.611 |
NEK5 |
0.837 | -0.067 | 1 | 0.850 |
CK2A2 |
0.837 | 0.138 | 1 | 0.721 |
P38G |
0.837 | 0.019 | 1 | 0.546 |
ERK1 |
0.836 | 0.003 | 1 | 0.622 |
DYRK1A |
0.836 | 0.013 | 1 | 0.741 |
DAPK3 |
0.836 | 0.114 | -3 | 0.824 |
MEK5 |
0.835 | -0.228 | 2 | 0.842 |
MEKK2 |
0.835 | -0.097 | 2 | 0.821 |
ERK2 |
0.835 | -0.025 | 1 | 0.666 |
PASK |
0.835 | 0.019 | -3 | 0.847 |
MEKK1 |
0.835 | -0.162 | 1 | 0.843 |
TAO3 |
0.834 | -0.017 | 1 | 0.828 |
MST3 |
0.834 | -0.009 | 2 | 0.857 |
PAK5 |
0.834 | 0.071 | -2 | 0.706 |
DYRK4 |
0.833 | 0.034 | 1 | 0.625 |
HIPK3 |
0.833 | 0.014 | 1 | 0.715 |
ZAK |
0.832 | -0.157 | 1 | 0.815 |
CDK17 |
0.832 | -0.004 | 1 | 0.553 |
GAK |
0.832 | 0.038 | 1 | 0.840 |
DYRK3 |
0.832 | 0.049 | 1 | 0.724 |
DYRK1B |
0.832 | 0.020 | 1 | 0.651 |
CDK12 |
0.832 | -0.030 | 1 | 0.621 |
IRAK4 |
0.832 | -0.105 | 1 | 0.815 |
PKCT |
0.831 | -0.017 | 2 | 0.754 |
CK1E |
0.831 | -0.043 | -3 | 0.550 |
CAMK1A |
0.831 | 0.127 | -3 | 0.679 |
NEK8 |
0.830 | -0.099 | 2 | 0.842 |
CDK9 |
0.830 | -0.055 | 1 | 0.652 |
DAPK1 |
0.830 | 0.097 | -3 | 0.802 |
GRK3 |
0.830 | -0.013 | -2 | 0.703 |
CHK2 |
0.830 | 0.085 | -3 | 0.662 |
CDK14 |
0.830 | 0.019 | 1 | 0.651 |
CAMKK1 |
0.829 | -0.121 | -2 | 0.812 |
TTBK1 |
0.829 | -0.143 | 2 | 0.670 |
P38D |
0.829 | 0.036 | 1 | 0.566 |
PKCI |
0.829 | 0.005 | 2 | 0.769 |
PAK4 |
0.829 | 0.064 | -2 | 0.713 |
TAO2 |
0.827 | -0.061 | 2 | 0.869 |
CDK16 |
0.827 | 0.034 | 1 | 0.570 |
CDK3 |
0.827 | 0.012 | 1 | 0.571 |
PLK2 |
0.827 | 0.040 | -3 | 0.808 |
PKCE |
0.826 | 0.042 | 2 | 0.746 |
BUB1 |
0.826 | 0.223 | -5 | 0.904 |
MRCKB |
0.826 | 0.099 | -3 | 0.766 |
MRCKA |
0.826 | 0.096 | -3 | 0.785 |
GSK3B |
0.826 | -0.033 | 4 | 0.433 |
MST2 |
0.825 | -0.041 | 1 | 0.847 |
CAMKK2 |
0.825 | -0.117 | -2 | 0.812 |
CDK10 |
0.825 | 0.032 | 1 | 0.634 |
PKN1 |
0.825 | 0.031 | -3 | 0.751 |
IRAK1 |
0.824 | -0.216 | -1 | 0.781 |
SGK1 |
0.824 | 0.069 | -3 | 0.621 |
LKB1 |
0.824 | -0.104 | -3 | 0.854 |
CK1D |
0.824 | -0.036 | -3 | 0.499 |
CK2A1 |
0.824 | 0.101 | 1 | 0.702 |
CK1A2 |
0.824 | -0.025 | -3 | 0.499 |
GSK3A |
0.824 | -0.007 | 4 | 0.442 |
MPSK1 |
0.824 | -0.062 | 1 | 0.793 |
TAK1 |
0.823 | -0.041 | 1 | 0.865 |
NEK4 |
0.823 | -0.093 | 1 | 0.827 |
AKT3 |
0.823 | 0.068 | -3 | 0.636 |
NEK11 |
0.823 | -0.195 | 1 | 0.825 |
GCK |
0.823 | -0.022 | 1 | 0.842 |
JNK1 |
0.823 | 0.009 | 1 | 0.608 |
EEF2K |
0.823 | -0.033 | 3 | 0.840 |
CK1G1 |
0.823 | -0.069 | -3 | 0.545 |
ROCK2 |
0.822 | 0.098 | -3 | 0.808 |
PDK1 |
0.822 | -0.117 | 1 | 0.809 |
TNIK |
0.822 | -0.004 | 3 | 0.861 |
MINK |
0.821 | -0.044 | 1 | 0.834 |
HGK |
0.820 | -0.051 | 3 | 0.856 |
SBK |
0.820 | 0.068 | -3 | 0.593 |
NEK1 |
0.819 | -0.055 | 1 | 0.823 |
ERK7 |
0.819 | -0.008 | 2 | 0.564 |
MST1 |
0.818 | -0.053 | 1 | 0.835 |
LOK |
0.818 | -0.041 | -2 | 0.814 |
HPK1 |
0.818 | -0.016 | 1 | 0.831 |
LRRK2 |
0.818 | -0.144 | 2 | 0.873 |
DMPK1 |
0.817 | 0.136 | -3 | 0.788 |
MEKK6 |
0.816 | -0.144 | 1 | 0.818 |
MAP3K15 |
0.815 | -0.155 | 1 | 0.796 |
VRK1 |
0.815 | -0.171 | 2 | 0.867 |
KHS2 |
0.814 | 0.039 | 1 | 0.841 |
KHS1 |
0.813 | 0.003 | 1 | 0.827 |
MAK |
0.813 | 0.053 | -2 | 0.760 |
CDK6 |
0.813 | -0.016 | 1 | 0.625 |
SLK |
0.813 | -0.079 | -2 | 0.754 |
MOK |
0.812 | 0.041 | 1 | 0.729 |
CDK4 |
0.812 | -0.014 | 1 | 0.611 |
STK33 |
0.811 | -0.164 | 2 | 0.658 |
PDHK3_TYR |
0.810 | 0.144 | 4 | 0.911 |
PKG1 |
0.810 | 0.039 | -2 | 0.651 |
YSK1 |
0.810 | -0.081 | 2 | 0.831 |
ROCK1 |
0.810 | 0.081 | -3 | 0.782 |
MEK2 |
0.809 | -0.236 | 2 | 0.829 |
RIPK2 |
0.809 | -0.228 | 1 | 0.777 |
PBK |
0.809 | -0.044 | 1 | 0.759 |
CRIK |
0.808 | 0.071 | -3 | 0.713 |
TTK |
0.808 | 0.025 | -2 | 0.867 |
NEK3 |
0.805 | -0.140 | 1 | 0.781 |
OSR1 |
0.802 | -0.094 | 2 | 0.817 |
PDHK4_TYR |
0.801 | 0.027 | 2 | 0.895 |
BIKE |
0.801 | 0.010 | 1 | 0.707 |
BMPR2_TYR |
0.801 | 0.031 | -1 | 0.901 |
MAP2K4_TYR |
0.801 | -0.067 | -1 | 0.898 |
TESK1_TYR |
0.800 | -0.088 | 3 | 0.898 |
HASPIN |
0.799 | -0.015 | -1 | 0.718 |
PDHK1_TYR |
0.799 | 0.002 | -1 | 0.922 |
MAP2K6_TYR |
0.799 | -0.042 | -1 | 0.899 |
MYO3B |
0.798 | -0.058 | 2 | 0.841 |
ALPHAK3 |
0.798 | -0.049 | -1 | 0.817 |
MAP2K7_TYR |
0.798 | -0.201 | 2 | 0.883 |
PINK1_TYR |
0.796 | -0.132 | 1 | 0.849 |
PKMYT1_TYR |
0.795 | -0.149 | 3 | 0.860 |
EPHA6 |
0.795 | 0.026 | -1 | 0.901 |
MYO3A |
0.795 | -0.087 | 1 | 0.820 |
TAO1 |
0.794 | -0.095 | 1 | 0.760 |
LIMK2_TYR |
0.793 | -0.048 | -3 | 0.898 |
RET |
0.793 | -0.071 | 1 | 0.832 |
YANK3 |
0.793 | -0.070 | 2 | 0.450 |
ASK1 |
0.792 | -0.197 | 1 | 0.782 |
EPHB4 |
0.791 | -0.019 | -1 | 0.879 |
MST1R |
0.789 | -0.100 | 3 | 0.809 |
TYK2 |
0.789 | -0.122 | 1 | 0.831 |
ABL2 |
0.787 | -0.002 | -1 | 0.864 |
TXK |
0.787 | 0.073 | 1 | 0.841 |
LIMK1_TYR |
0.787 | -0.214 | 2 | 0.875 |
JAK2 |
0.786 | -0.118 | 1 | 0.826 |
ROS1 |
0.785 | -0.119 | 3 | 0.769 |
CK1A |
0.785 | -0.070 | -3 | 0.408 |
TYRO3 |
0.785 | -0.149 | 3 | 0.796 |
FER |
0.785 | -0.088 | 1 | 0.871 |
AAK1 |
0.784 | 0.046 | 1 | 0.599 |
YES1 |
0.784 | -0.047 | -1 | 0.878 |
STLK3 |
0.784 | -0.196 | 1 | 0.792 |
ABL1 |
0.784 | -0.023 | -1 | 0.857 |
EPHA4 |
0.783 | -0.027 | 2 | 0.807 |
CSF1R |
0.783 | -0.116 | 3 | 0.781 |
FGR |
0.783 | -0.081 | 1 | 0.853 |
EPHB1 |
0.783 | -0.027 | 1 | 0.859 |
DDR1 |
0.783 | -0.180 | 4 | 0.833 |
SRMS |
0.783 | -0.040 | 1 | 0.860 |
ITK |
0.782 | -0.029 | -1 | 0.844 |
HCK |
0.781 | -0.049 | -1 | 0.871 |
JAK3 |
0.781 | -0.122 | 1 | 0.803 |
EPHB2 |
0.781 | -0.017 | -1 | 0.868 |
INSRR |
0.781 | -0.087 | 3 | 0.750 |
EPHB3 |
0.780 | -0.052 | -1 | 0.864 |
LCK |
0.780 | -0.005 | -1 | 0.875 |
BLK |
0.779 | 0.024 | -1 | 0.887 |
FGFR2 |
0.779 | -0.133 | 3 | 0.804 |
FLT3 |
0.779 | -0.106 | 3 | 0.787 |
PDGFRB |
0.777 | -0.160 | 3 | 0.799 |
TNK2 |
0.777 | -0.104 | 3 | 0.749 |
TEC |
0.777 | -0.020 | -1 | 0.796 |
KIT |
0.777 | -0.125 | 3 | 0.784 |
TNNI3K_TYR |
0.777 | -0.039 | 1 | 0.836 |
BMX |
0.776 | -0.019 | -1 | 0.775 |
KDR |
0.776 | -0.109 | 3 | 0.751 |
MERTK |
0.775 | -0.075 | 3 | 0.778 |
NEK10_TYR |
0.775 | -0.113 | 1 | 0.704 |
JAK1 |
0.774 | -0.079 | 1 | 0.776 |
EPHA7 |
0.773 | -0.050 | 2 | 0.811 |
TEK |
0.773 | -0.167 | 3 | 0.730 |
AXL |
0.773 | -0.130 | 3 | 0.777 |
FYN |
0.773 | 0.014 | -1 | 0.853 |
BTK |
0.773 | -0.147 | -1 | 0.800 |
FGFR1 |
0.773 | -0.165 | 3 | 0.771 |
TNK1 |
0.772 | -0.131 | 3 | 0.774 |
LTK |
0.772 | -0.103 | 3 | 0.740 |
FRK |
0.772 | -0.039 | -1 | 0.894 |
WEE1_TYR |
0.772 | -0.095 | -1 | 0.777 |
PDGFRA |
0.771 | -0.199 | 3 | 0.795 |
ALK |
0.771 | -0.123 | 3 | 0.716 |
EPHA3 |
0.771 | -0.099 | 2 | 0.787 |
MET |
0.771 | -0.127 | 3 | 0.779 |
PTK6 |
0.770 | -0.164 | -1 | 0.770 |
FLT1 |
0.770 | -0.113 | -1 | 0.878 |
ERBB2 |
0.769 | -0.138 | 1 | 0.790 |
NTRK1 |
0.769 | -0.182 | -1 | 0.843 |
CK1G3 |
0.768 | -0.064 | -3 | 0.359 |
EPHA1 |
0.768 | -0.104 | 3 | 0.754 |
PTK2B |
0.768 | -0.027 | -1 | 0.830 |
LYN |
0.767 | -0.072 | 3 | 0.709 |
FLT4 |
0.767 | -0.159 | 3 | 0.749 |
EPHA5 |
0.766 | -0.053 | 2 | 0.794 |
FGFR3 |
0.766 | -0.159 | 3 | 0.773 |
EGFR |
0.765 | -0.051 | 1 | 0.697 |
EPHA8 |
0.765 | -0.055 | -1 | 0.859 |
NTRK2 |
0.765 | -0.202 | 3 | 0.757 |
MATK |
0.764 | -0.114 | -1 | 0.798 |
PTK2 |
0.764 | 0.029 | -1 | 0.820 |
INSR |
0.763 | -0.173 | 3 | 0.722 |
CSK |
0.763 | -0.105 | 2 | 0.813 |
SRC |
0.761 | -0.074 | -1 | 0.854 |
NTRK3 |
0.760 | -0.163 | -1 | 0.794 |
DDR2 |
0.760 | -0.111 | 3 | 0.737 |
SYK |
0.759 | 0.000 | -1 | 0.820 |
FGFR4 |
0.758 | -0.097 | -1 | 0.822 |
YANK2 |
0.758 | -0.105 | 2 | 0.459 |
EPHA2 |
0.754 | -0.072 | -1 | 0.821 |
IGF1R |
0.751 | -0.139 | 3 | 0.666 |
MUSK |
0.750 | -0.148 | 1 | 0.685 |
ERBB4 |
0.750 | -0.057 | 1 | 0.716 |
CK1G2 |
0.745 | -0.085 | -3 | 0.460 |
FES |
0.739 | -0.137 | -1 | 0.754 |
ZAP70 |
0.728 | -0.091 | -1 | 0.739 |