Motif 644 (n=64)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00425 | IGF2BP3 | S243 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O60292 | SIPA1L3 | S1534 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60563 | CCNT1 | S352 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O75391 | SPAG7 | S63 | ochoa | Sperm-associated antigen 7 | None |
| O75832 | PSMD10 | S115 | ochoa | 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
| O94822 | LTN1 | S579 | ochoa | E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) | E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). {ECO:0000250|UniProtKB:Q04781, ECO:0000269|PubMed:23685075, ECO:0000269|PubMed:25132172, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:28757607}. |
| P04049 | RAF1 | S471 | psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P07900 | HSP90AA1 | S505 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S497 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10398 | ARAF | S432 | psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10515 | DLAT | S475 | ochoa | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). {ECO:0000305|PubMed:20160912}. |
| P11055 | MYH3 | Y1376 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | Y1379 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | Y1375 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12956 | XRCC6 | S180 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13533 | MYH6 | Y1377 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | Y1378 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14625 | HSP90B1 | S106 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15056 | BRAF | S579 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15622 | ZNF250 | S168 | ochoa | Zinc finger protein 250 (Zinc finger protein 647) | May be involved in transcriptional regulation. |
| P20929 | NEB | S1865 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P22059 | OSBP | S200 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P23526 | AHCY | S187 | ochoa | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P24588 | AKAP5 | S81 | ochoa | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}. |
| P29590 | PML | S582 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P38398 | BRCA1 | S308 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40227 | CCT6A | S200 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P46013 | MKI67 | S2838 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48444 | ARCN1 | S493 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49759 | CLK1 | S328 | ochoa | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
| P61026 | RAB10 | S77 | ochoa | Ras-related protein Rab-10 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. |
| P62314 | SNRPD1 | S59 | ochoa | Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000305|PubMed:23333303}. |
| Q13206 | DDX10 | S840 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13315 | ATM | S1987 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13422 | IKZF1 | S393 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q14680 | MELK | S407 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q58FF7 | HSP90AB3P | S370 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5QJE6 | DNTTIP2 | S245 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q86UP2 | KTN1 | S79 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q92614 | MYO18A | S2031 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q96TC7 | RMDN3 | S224 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99767 | APBA2 | S208 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BSC4 | NOL10 | S607 | ochoa | Nucleolar protein 10 | None |
| Q9BVI0 | PHF20 | S225 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9C0C2 | TNKS1BP1 | S1677 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S243 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H6N6 | MYH16 | Y538 | ochoa | Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) | Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303|PubMed:15042088}. |
| Q9HAZ1 | CLK4 | S326 | ochoa | Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. |
| Q9HD26 | GOPC | S439 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NYL9 | TMOD3 | S25 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9UKX2 | MYH2 | Y1381 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | Y1379 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULT0 | TTC7A | S674 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UM54 | MYO6 | S1142 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9Y2D4 | EXOC6B | S265 | ochoa | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q9Y448 | KNSTRN | S241 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
| Q9Y623 | MYH4 | Y1379 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q3B891 | BRCA1 | S308 | GPS6 | BRCA1 DNA repair associated (BRCA1 protein) | None |
| Q9GZZ9 | UBA5 | S54 | Sugiyama | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| P02671 | FGA | S618 | ELM | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P52907 | CAPZA1 | S244 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P10809 | HSPD1 | S175 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| Q5T9S5 | CCDC18 | S336 | Sugiyama | Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) | None |
| P47755 | CAPZA2 | S244 | Sugiyama | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.962593e-07 | 6.707 |
| R-HSA-390522 | Striated Muscle Contraction | 1.508641e-06 | 5.821 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.627354e-05 | 4.789 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 2.158670e-05 | 4.666 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 2.158670e-05 | 4.666 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.112222e-05 | 4.214 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 9.235105e-05 | 4.035 |
| R-HSA-5674135 | MAP2K and MAPK activation | 9.235105e-05 | 4.035 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.691338e-05 | 4.014 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.338153e-04 | 3.873 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.338153e-04 | 3.873 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.338153e-04 | 3.873 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.338153e-04 | 3.873 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.177320e-04 | 3.379 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.855523e-04 | 3.314 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 6.864067e-04 | 3.163 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.660837e-04 | 3.062 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.025029e-03 | 2.989 |
| R-HSA-5673000 | RAF activation | 1.009879e-03 | 2.996 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.065979e-03 | 2.972 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.285903e-03 | 2.891 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.525668e-03 | 2.817 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.785087e-03 | 2.748 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.677993e-03 | 2.775 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.785087e-03 | 2.748 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.446409e-03 | 2.611 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.362146e-03 | 2.627 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.679419e-03 | 2.572 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 3.015612e-03 | 2.521 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.744036e-03 | 2.427 |
| R-HSA-397014 | Muscle contraction | 4.918767e-03 | 2.308 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 5.883712e-03 | 2.230 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 6.364869e-03 | 2.196 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.364869e-03 | 2.196 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.364869e-03 | 2.196 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 6.364869e-03 | 2.196 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.420064e-03 | 2.266 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.027381e-03 | 2.044 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 8.461208e-03 | 2.073 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 9.395406e-03 | 2.027 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 9.395406e-03 | 2.027 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 9.610058e-03 | 2.017 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.019468e-02 | 1.992 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 1.406039e-02 | 1.852 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 1.870369e-02 | 1.728 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 1.870369e-02 | 1.728 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 1.870369e-02 | 1.728 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 1.870369e-02 | 1.728 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 1.870369e-02 | 1.728 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 1.870369e-02 | 1.728 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 1.870369e-02 | 1.728 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 1.870369e-02 | 1.728 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 1.870369e-02 | 1.728 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 1.870369e-02 | 1.728 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 1.870369e-02 | 1.728 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 1.870369e-02 | 1.728 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.210254e-02 | 1.917 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.557017e-02 | 1.808 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.510740e-02 | 1.821 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.344361e-02 | 1.871 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.630906e-02 | 1.788 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.630906e-02 | 1.788 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.484619e-02 | 1.828 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.557017e-02 | 1.808 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.484619e-02 | 1.828 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.438647e-02 | 1.842 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.630906e-02 | 1.788 |
| R-HSA-3371511 | HSF1 activation | 1.783099e-02 | 1.749 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.706272e-02 | 1.768 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.344361e-02 | 1.871 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.082427e-02 | 1.966 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.783099e-02 | 1.749 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.484619e-02 | 1.828 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.941077e-02 | 1.712 |
| R-HSA-69541 | Stabilization of p53 | 2.022198e-02 | 1.694 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.022198e-02 | 1.694 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.022198e-02 | 1.694 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.022198e-02 | 1.694 |
| R-HSA-3371568 | Attenuation phase | 2.104721e-02 | 1.677 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.720412e-02 | 1.565 |
| R-HSA-3371556 | Cellular response to heat stress | 2.632774e-02 | 1.580 |
| R-HSA-9675135 | Diseases of DNA repair | 2.720412e-02 | 1.565 |
| R-HSA-2262752 | Cellular responses to stress | 2.403550e-02 | 1.619 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.250813e-02 | 1.648 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.537852e-02 | 1.596 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.003875e-02 | 1.522 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.003875e-02 | 1.522 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.008852e-02 | 1.522 |
| R-HSA-912446 | Meiotic recombination | 3.199105e-02 | 1.495 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.199105e-02 | 1.495 |
| R-HSA-212436 | Generic Transcription Pathway | 3.204617e-02 | 1.494 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.298555e-02 | 1.482 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.322967e-02 | 1.478 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.027746e-02 | 1.395 |
| R-HSA-191859 | snRNP Assembly | 4.027746e-02 | 1.395 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.027746e-02 | 1.395 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.706207e-02 | 1.431 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 3.706207e-02 | 1.431 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.604091e-02 | 1.443 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.117366e-02 | 1.385 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.469250e-02 | 1.350 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.353670e-02 | 1.361 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.501062e-02 | 1.456 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.911876e-02 | 1.408 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.357244e-02 | 1.361 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.611168e-02 | 1.442 |
| R-HSA-373755 | Semaphorin interactions | 4.469250e-02 | 1.350 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 4.611374e-02 | 1.336 |
| R-HSA-8948747 | Regulation of PTEN localization | 4.611374e-02 | 1.336 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.696445e-02 | 1.328 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.720614e-02 | 1.326 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.751429e-02 | 1.323 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 5.060803e-02 | 1.296 |
| R-HSA-164843 | 2-LTR circle formation | 5.953402e-02 | 1.225 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 7.276795e-02 | 1.138 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.656058e-02 | 1.177 |
| R-HSA-9664873 | Pexophagy | 5.953402e-02 | 1.225 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.927805e-02 | 1.307 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.927805e-02 | 1.307 |
| R-HSA-190873 | Gap junction degradation | 5.508143e-02 | 1.259 |
| R-HSA-192905 | vRNP Assembly | 6.396591e-02 | 1.194 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 7.276795e-02 | 1.138 |
| R-HSA-1500620 | Meiosis | 7.182087e-02 | 1.144 |
| R-HSA-170984 | ARMS-mediated activation | 5.508143e-02 | 1.259 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 5.953402e-02 | 1.225 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 6.837719e-02 | 1.165 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.872457e-02 | 1.231 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.270114e-02 | 1.203 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 7.276795e-02 | 1.138 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.768992e-02 | 1.239 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 5.508143e-02 | 1.259 |
| R-HSA-877300 | Interferon gamma signaling | 5.166535e-02 | 1.287 |
| R-HSA-162592 | Integration of provirus | 6.837719e-02 | 1.165 |
| R-HSA-9612973 | Autophagy | 4.956830e-02 | 1.305 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.045017e-02 | 1.297 |
| R-HSA-9659379 | Sensory processing of sound | 6.398153e-02 | 1.194 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.356110e-02 | 1.197 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.752485e-02 | 1.240 |
| R-HSA-9020591 | Interleukin-12 signaling | 6.017927e-02 | 1.221 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.450042e-02 | 1.128 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.585218e-02 | 1.120 |
| R-HSA-447115 | Interleukin-12 family signaling | 7.585218e-02 | 1.120 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 7.713829e-02 | 1.113 |
| R-HSA-170968 | Frs2-mediated activation | 7.713829e-02 | 1.113 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 7.713829e-02 | 1.113 |
| R-HSA-9663891 | Selective autophagy | 7.721180e-02 | 1.112 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 9.012770e-02 | 1.045 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 9.868690e-02 | 1.006 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 9.868690e-02 | 1.006 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 9.868690e-02 | 1.006 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.155676e-01 | 0.937 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.155676e-01 | 0.937 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.155676e-01 | 0.937 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.197388e-01 | 0.922 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.443614e-01 | 0.841 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.443614e-01 | 0.841 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.483985e-01 | 0.829 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.483985e-01 | 0.829 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.403054e-01 | 0.853 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.196238e-01 | 0.922 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.403054e-01 | 0.853 |
| R-HSA-5693538 | Homology Directed Repair | 1.290055e-01 | 0.889 |
| R-HSA-391251 | Protein folding | 8.412417e-02 | 1.075 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 1.524169e-01 | 0.817 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.029367e-01 | 0.987 |
| R-HSA-169893 | Prolonged ERK activation events | 9.012770e-02 | 1.045 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.564165e-01 | 0.806 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.321363e-01 | 0.879 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.321363e-01 | 0.879 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.029367e-01 | 0.987 |
| R-HSA-9857492 | Protein lipoylation | 8.581807e-02 | 1.066 |
| R-HSA-429947 | Deadenylation of mRNA | 1.321363e-01 | 0.879 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.524169e-01 | 0.817 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.071666e-01 | 0.970 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 8.581807e-02 | 1.066 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.579451e-02 | 1.019 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 8.581807e-02 | 1.066 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.403054e-01 | 0.853 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.531896e-02 | 1.069 |
| R-HSA-1474165 | Reproduction | 1.515182e-01 | 0.820 |
| R-HSA-392517 | Rap1 signalling | 1.071666e-01 | 0.970 |
| R-HSA-622312 | Inflammasomes | 1.483985e-01 | 0.829 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.483985e-01 | 0.829 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.524169e-01 | 0.817 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.564165e-01 | 0.806 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.442701e-01 | 0.841 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.113769e-01 | 0.953 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 1.564165e-01 | 0.806 |
| R-HSA-69481 | G2/M Checkpoints | 1.450051e-01 | 0.839 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.711002e-02 | 1.060 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.623164e-02 | 1.017 |
| R-HSA-8939211 | ESR-mediated signaling | 1.219350e-01 | 0.914 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.564165e-01 | 0.806 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.029367e-01 | 0.987 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.155676e-01 | 0.937 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.238906e-01 | 0.907 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 1.362303e-01 | 0.866 |
| R-HSA-392499 | Metabolism of proteins | 1.015711e-01 | 0.993 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.075983e-01 | 0.968 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 9.012770e-02 | 1.045 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.071666e-01 | 0.970 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.403054e-01 | 0.853 |
| R-HSA-597592 | Post-translational protein modification | 9.491687e-02 | 1.023 |
| R-HSA-168249 | Innate Immune System | 1.024046e-01 | 0.990 |
| R-HSA-74160 | Gene expression (Transcription) | 8.127414e-02 | 1.090 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.831802e-02 | 1.106 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.443614e-01 | 0.841 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.369520e-01 | 0.863 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.835947e-02 | 1.054 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.441979e-01 | 0.841 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.723444e-02 | 1.012 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.647137e-01 | 0.783 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.680448e-01 | 0.775 |
| R-HSA-354192 | Integrin signaling | 1.683040e-01 | 0.774 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.683040e-01 | 0.774 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.683040e-01 | 0.774 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.683040e-01 | 0.774 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.683040e-01 | 0.774 |
| R-HSA-1632852 | Macroautophagy | 1.713876e-01 | 0.766 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.747417e-01 | 0.758 |
| R-HSA-203615 | eNOS activation | 1.761370e-01 | 0.754 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.761370e-01 | 0.754 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.761370e-01 | 0.754 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 1.761370e-01 | 0.754 |
| R-HSA-187687 | Signalling to ERKs | 1.800262e-01 | 0.745 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 1.800262e-01 | 0.745 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.800262e-01 | 0.745 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.838972e-01 | 0.735 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 1.838972e-01 | 0.735 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.877502e-01 | 0.726 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 1.882616e-01 | 0.725 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.882616e-01 | 0.725 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.882616e-01 | 0.725 |
| R-HSA-6798695 | Neutrophil degranulation | 1.894817e-01 | 0.722 |
| R-HSA-449147 | Signaling by Interleukins | 1.896321e-01 | 0.722 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.915853e-01 | 0.718 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.915853e-01 | 0.718 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.954025e-01 | 0.709 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.992019e-01 | 0.701 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.992019e-01 | 0.701 |
| R-HSA-167169 | HIV Transcription Elongation | 1.992019e-01 | 0.701 |
| R-HSA-5260271 | Diseases of Immune System | 1.992019e-01 | 0.701 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.992019e-01 | 0.701 |
| R-HSA-9646399 | Aggrephagy | 1.992019e-01 | 0.701 |
| R-HSA-162587 | HIV Life Cycle | 2.002093e-01 | 0.699 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.029835e-01 | 0.693 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.029835e-01 | 0.693 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.067476e-01 | 0.685 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 2.067476e-01 | 0.685 |
| R-HSA-199991 | Membrane Trafficking | 2.086348e-01 | 0.681 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.104941e-01 | 0.677 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.142232e-01 | 0.669 |
| R-HSA-9907900 | Proteasome assembly | 2.179348e-01 | 0.662 |
| R-HSA-190828 | Gap junction trafficking | 2.179348e-01 | 0.662 |
| R-HSA-156581 | Methylation | 2.179348e-01 | 0.662 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.216292e-01 | 0.654 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.216292e-01 | 0.654 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.253064e-01 | 0.647 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 2.253064e-01 | 0.647 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 2.253064e-01 | 0.647 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.330397e-01 | 0.633 |
| R-HSA-168256 | Immune System | 2.360615e-01 | 0.627 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.362352e-01 | 0.627 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.470120e-01 | 0.607 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.470120e-01 | 0.607 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.505707e-01 | 0.601 |
| R-HSA-1221632 | Meiotic synapsis | 2.505707e-01 | 0.601 |
| R-HSA-69275 | G2/M Transition | 2.522132e-01 | 0.598 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.557060e-01 | 0.592 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.576386e-01 | 0.589 |
| R-HSA-1640170 | Cell Cycle | 2.608987e-01 | 0.584 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.609474e-01 | 0.583 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.611478e-01 | 0.583 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.611478e-01 | 0.583 |
| R-HSA-1643685 | Disease | 2.643609e-01 | 0.578 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.646406e-01 | 0.577 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.661905e-01 | 0.575 |
| R-HSA-73894 | DNA Repair | 2.669487e-01 | 0.574 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.715775e-01 | 0.566 |
| R-HSA-8873719 | RAB geranylgeranylation | 2.750217e-01 | 0.561 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.750217e-01 | 0.561 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 2.750217e-01 | 0.561 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 2.750217e-01 | 0.561 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.818619e-01 | 0.550 |
| R-HSA-1268020 | Mitochondrial protein import | 2.818619e-01 | 0.550 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.818619e-01 | 0.550 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.852581e-01 | 0.545 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.852581e-01 | 0.545 |
| R-HSA-72172 | mRNA Splicing | 2.854125e-01 | 0.545 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.886384e-01 | 0.540 |
| R-HSA-9679506 | SARS-CoV Infections | 2.888205e-01 | 0.539 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.953518e-01 | 0.530 |
| R-HSA-9824446 | Viral Infection Pathways | 2.976566e-01 | 0.526 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.977583e-01 | 0.526 |
| R-HSA-913531 | Interferon Signaling | 2.977583e-01 | 0.526 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.993691e-01 | 0.524 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.011112e-01 | 0.521 |
| R-HSA-167172 | Transcription of the HIV genome | 3.020027e-01 | 0.520 |
| R-HSA-5218859 | Regulated Necrosis | 3.020027e-01 | 0.520 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.085916e-01 | 0.511 |
| R-HSA-8978934 | Metabolism of cofactors | 3.118630e-01 | 0.506 |
| R-HSA-8951664 | Neddylation | 3.150225e-01 | 0.502 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.183601e-01 | 0.497 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.183601e-01 | 0.497 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.215859e-01 | 0.493 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.215859e-01 | 0.493 |
| R-HSA-380287 | Centrosome maturation | 3.247966e-01 | 0.488 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.247966e-01 | 0.488 |
| R-HSA-162906 | HIV Infection | 3.254193e-01 | 0.488 |
| R-HSA-216083 | Integrin cell surface interactions | 3.343390e-01 | 0.476 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 3.374902e-01 | 0.472 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.406266e-01 | 0.468 |
| R-HSA-977225 | Amyloid fiber formation | 3.437484e-01 | 0.464 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.482091e-01 | 0.458 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.530265e-01 | 0.452 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.560903e-01 | 0.448 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.591398e-01 | 0.445 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.621751e-01 | 0.441 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 3.621751e-01 | 0.441 |
| R-HSA-70268 | Pyruvate metabolism | 3.651961e-01 | 0.437 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.682031e-01 | 0.434 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.711960e-01 | 0.430 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.741749e-01 | 0.427 |
| R-HSA-9837999 | Mitochondrial protein degradation | 3.888618e-01 | 0.410 |
| R-HSA-1280218 | Adaptive Immune System | 3.904774e-01 | 0.408 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.946408e-01 | 0.404 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.975101e-01 | 0.401 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.003659e-01 | 0.398 |
| R-HSA-422356 | Regulation of insulin secretion | 4.032084e-01 | 0.394 |
| R-HSA-190236 | Signaling by FGFR | 4.032084e-01 | 0.394 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.051022e-01 | 0.392 |
| R-HSA-3214847 | HATs acetylate histones | 4.060376e-01 | 0.391 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 4.060376e-01 | 0.391 |
| R-HSA-112316 | Neuronal System | 4.073015e-01 | 0.390 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.116563e-01 | 0.385 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.133396e-01 | 0.384 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.144460e-01 | 0.383 |
| R-HSA-9658195 | Leishmania infection | 4.166193e-01 | 0.380 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.166193e-01 | 0.380 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.182558e-01 | 0.379 |
| R-HSA-211000 | Gene Silencing by RNA | 4.309119e-01 | 0.366 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.336114e-01 | 0.363 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.336114e-01 | 0.363 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 4.389726e-01 | 0.358 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.573455e-01 | 0.340 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.624849e-01 | 0.335 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.675763e-01 | 0.330 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.675763e-01 | 0.330 |
| R-HSA-162582 | Signal Transduction | 4.750080e-01 | 0.323 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.751243e-01 | 0.323 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.751243e-01 | 0.323 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.776168e-01 | 0.321 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.800975e-01 | 0.319 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.832663e-01 | 0.316 |
| R-HSA-194138 | Signaling by VEGF | 4.850243e-01 | 0.314 |
| R-HSA-114608 | Platelet degranulation | 4.899049e-01 | 0.310 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.923281e-01 | 0.308 |
| R-HSA-422475 | Axon guidance | 5.022839e-01 | 0.299 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.066304e-01 | 0.295 |
| R-HSA-163685 | Integration of energy metabolism | 5.159436e-01 | 0.287 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.205349e-01 | 0.284 |
| R-HSA-6807070 | PTEN Regulation | 5.228144e-01 | 0.282 |
| R-HSA-9664407 | Parasite infection | 5.250833e-01 | 0.280 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.250833e-01 | 0.280 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.250833e-01 | 0.280 |
| R-HSA-109582 | Hemostasis | 5.305699e-01 | 0.275 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.318261e-01 | 0.274 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.450295e-01 | 0.264 |
| R-HSA-166520 | Signaling by NTRKs | 5.450295e-01 | 0.264 |
| R-HSA-9675108 | Nervous system development | 5.452227e-01 | 0.263 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.514927e-01 | 0.258 |
| R-HSA-9609507 | Protein localization | 5.557511e-01 | 0.255 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.578653e-01 | 0.253 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.599696e-01 | 0.252 |
| R-HSA-5663205 | Infectious disease | 5.666004e-01 | 0.247 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.703436e-01 | 0.244 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.784688e-01 | 0.238 |
| R-HSA-8953854 | Metabolism of RNA | 5.798100e-01 | 0.237 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.808319e-01 | 0.236 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.942668e-01 | 0.226 |
| R-HSA-168255 | Influenza Infection | 6.094803e-01 | 0.215 |
| R-HSA-2559583 | Cellular Senescence | 6.113420e-01 | 0.214 |
| R-HSA-983712 | Ion channel transport | 6.277076e-01 | 0.202 |
| R-HSA-5617833 | Cilium Assembly | 6.294835e-01 | 0.201 |
| R-HSA-68877 | Mitotic Prometaphase | 6.347611e-01 | 0.197 |
| R-HSA-9609690 | HCMV Early Events | 6.399645e-01 | 0.194 |
| R-HSA-428157 | Sphingolipid metabolism | 6.484748e-01 | 0.188 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.518231e-01 | 0.186 |
| R-HSA-5357801 | Programmed Cell Death | 6.567865e-01 | 0.183 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.896286e-01 | 0.161 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.013067e-01 | 0.154 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 7.083842e-01 | 0.150 |
| R-HSA-157118 | Signaling by NOTCH | 7.097797e-01 | 0.149 |
| R-HSA-4839726 | Chromatin organization | 7.220463e-01 | 0.141 |
| R-HSA-9609646 | HCMV Infection | 7.233773e-01 | 0.141 |
| R-HSA-5688426 | Deubiquitination | 7.299384e-01 | 0.137 |
| R-HSA-211859 | Biological oxidations | 7.315614e-01 | 0.136 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.462870e-01 | 0.127 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.581947e-01 | 0.120 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.695147e-01 | 0.114 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.771849e-01 | 0.109 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.024676e-01 | 0.096 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.053045e-01 | 0.094 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.056563e-01 | 0.094 |
| R-HSA-8957322 | Metabolism of steroids | 8.062411e-01 | 0.094 |
| R-HSA-1474244 | Extracellular matrix organization | 8.126744e-01 | 0.090 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.215006e-01 | 0.085 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.223603e-01 | 0.085 |
| R-HSA-1266738 | Developmental Biology | 8.356495e-01 | 0.078 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.402734e-01 | 0.076 |
| R-HSA-68886 | M Phase | 8.543007e-01 | 0.068 |
| R-HSA-5668914 | Diseases of metabolism | 8.828568e-01 | 0.054 |
| R-HSA-72766 | Translation | 8.839887e-01 | 0.054 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.539167e-01 | 0.020 |
| R-HSA-9709957 | Sensory Perception | 9.846264e-01 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 9.924226e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.994346e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.998986e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.767 | 0.279 | 1 | 0.778 |
COT |
0.764 | 0.180 | 2 | 0.691 |
PIM3 |
0.755 | 0.197 | -3 | 0.831 |
MOS |
0.753 | 0.232 | 1 | 0.778 |
SRPK1 |
0.752 | 0.224 | -3 | 0.807 |
CDKL1 |
0.749 | 0.187 | -3 | 0.835 |
CDC7 |
0.748 | 0.191 | 1 | 0.760 |
CHAK2 |
0.748 | 0.199 | -1 | 0.778 |
GRK1 |
0.747 | 0.205 | -2 | 0.794 |
CDKL5 |
0.747 | 0.167 | -3 | 0.830 |
SRPK2 |
0.746 | 0.210 | -3 | 0.754 |
DSTYK |
0.745 | 0.058 | 2 | 0.698 |
HIPK4 |
0.745 | 0.132 | 1 | 0.744 |
NDR2 |
0.744 | 0.101 | -3 | 0.807 |
PRKD1 |
0.744 | 0.130 | -3 | 0.812 |
PRKD2 |
0.744 | 0.171 | -3 | 0.758 |
PIM1 |
0.743 | 0.184 | -3 | 0.792 |
PRPK |
0.742 | -0.031 | -1 | 0.675 |
KIS |
0.742 | 0.085 | 1 | 0.619 |
SKMLCK |
0.741 | 0.122 | -2 | 0.756 |
CAMK1B |
0.740 | 0.103 | -3 | 0.846 |
GCN2 |
0.740 | -0.095 | 2 | 0.608 |
RAF1 |
0.740 | 0.036 | 1 | 0.688 |
PKCD |
0.739 | 0.125 | 2 | 0.637 |
CLK2 |
0.739 | 0.225 | -3 | 0.790 |
NLK |
0.739 | 0.032 | 1 | 0.703 |
SRPK3 |
0.738 | 0.188 | -3 | 0.790 |
FAM20C |
0.738 | 0.041 | 2 | 0.395 |
RIPK3 |
0.737 | 0.040 | 3 | 0.630 |
ERK5 |
0.737 | 0.043 | 1 | 0.736 |
MTOR |
0.737 | -0.032 | 1 | 0.640 |
LATS2 |
0.737 | 0.125 | -5 | 0.651 |
BMPR1B |
0.737 | 0.183 | 1 | 0.737 |
NDR1 |
0.737 | 0.076 | -3 | 0.814 |
IKKB |
0.736 | -0.019 | -2 | 0.668 |
MARK4 |
0.736 | 0.076 | 4 | 0.741 |
PKCB |
0.736 | 0.111 | 2 | 0.613 |
ICK |
0.735 | 0.132 | -3 | 0.842 |
PKN3 |
0.734 | 0.064 | -3 | 0.816 |
MLK1 |
0.734 | -0.018 | 2 | 0.650 |
PKN2 |
0.734 | 0.068 | -3 | 0.802 |
CAMK2G |
0.734 | -0.033 | 2 | 0.573 |
HUNK |
0.734 | 0.055 | 2 | 0.610 |
NUAK2 |
0.734 | 0.106 | -3 | 0.812 |
ULK2 |
0.733 | -0.087 | 2 | 0.612 |
MST4 |
0.733 | 0.048 | 2 | 0.637 |
DYRK2 |
0.733 | 0.104 | 1 | 0.647 |
RSK2 |
0.733 | 0.108 | -3 | 0.809 |
WNK1 |
0.733 | 0.038 | -2 | 0.772 |
NEK7 |
0.732 | -0.059 | -3 | 0.743 |
LATS1 |
0.732 | 0.173 | -3 | 0.832 |
NIK |
0.732 | 0.056 | -3 | 0.831 |
BMPR2 |
0.732 | -0.096 | -2 | 0.752 |
CLK1 |
0.732 | 0.155 | -3 | 0.774 |
BCKDK |
0.732 | -0.030 | -1 | 0.643 |
P70S6KB |
0.731 | 0.094 | -3 | 0.806 |
CLK4 |
0.731 | 0.139 | -3 | 0.801 |
NEK6 |
0.731 | -0.040 | -2 | 0.740 |
PKR |
0.730 | 0.154 | 1 | 0.741 |
GRK5 |
0.730 | -0.003 | -3 | 0.796 |
DAPK2 |
0.730 | 0.068 | -3 | 0.846 |
GRK6 |
0.730 | 0.066 | 1 | 0.708 |
CAMLCK |
0.730 | 0.030 | -2 | 0.701 |
ATR |
0.730 | -0.053 | 1 | 0.670 |
IRE1 |
0.729 | 0.032 | 1 | 0.723 |
PKCG |
0.729 | 0.058 | 2 | 0.603 |
NUAK1 |
0.729 | 0.123 | -3 | 0.781 |
PRKD3 |
0.729 | 0.121 | -3 | 0.773 |
MAPKAPK3 |
0.729 | 0.072 | -3 | 0.770 |
RSK3 |
0.729 | 0.082 | -3 | 0.811 |
PKCZ |
0.729 | 0.107 | 2 | 0.631 |
P90RSK |
0.729 | 0.080 | -3 | 0.817 |
PDHK4 |
0.729 | -0.203 | 1 | 0.694 |
MAPKAPK2 |
0.728 | 0.118 | -3 | 0.745 |
MLK3 |
0.728 | 0.015 | 2 | 0.604 |
PKACG |
0.728 | 0.062 | -2 | 0.631 |
IKKA |
0.728 | 0.037 | -2 | 0.676 |
ANKRD3 |
0.728 | 0.010 | 1 | 0.688 |
TBK1 |
0.727 | -0.110 | 1 | 0.552 |
HIPK2 |
0.727 | 0.116 | 1 | 0.575 |
MSK2 |
0.727 | 0.087 | -3 | 0.792 |
TSSK2 |
0.726 | 0.064 | -5 | 0.617 |
IRE2 |
0.726 | 0.012 | 2 | 0.603 |
TGFBR2 |
0.726 | -0.057 | -2 | 0.674 |
ULK1 |
0.726 | -0.083 | -3 | 0.711 |
AMPKA1 |
0.725 | 0.072 | -3 | 0.810 |
CAMK1G |
0.725 | 0.132 | -3 | 0.777 |
RIPK1 |
0.725 | -0.012 | 1 | 0.683 |
PKCA |
0.725 | 0.049 | 2 | 0.608 |
CHAK1 |
0.725 | 0.043 | 2 | 0.613 |
HIPK1 |
0.725 | 0.117 | 1 | 0.659 |
PKCH |
0.724 | 0.053 | 2 | 0.600 |
RSK4 |
0.724 | 0.123 | -3 | 0.775 |
ATM |
0.724 | -0.022 | 1 | 0.613 |
MLK2 |
0.724 | -0.058 | 2 | 0.660 |
IKKE |
0.724 | -0.125 | 1 | 0.554 |
GRK7 |
0.724 | 0.113 | 1 | 0.645 |
GRK4 |
0.724 | 0.002 | -2 | 0.781 |
CDK1 |
0.724 | 0.068 | 1 | 0.556 |
DLK |
0.724 | 0.002 | 1 | 0.680 |
PDHK1 |
0.724 | -0.198 | 1 | 0.686 |
QSK |
0.723 | 0.090 | 4 | 0.708 |
NIM1 |
0.723 | -0.021 | 3 | 0.658 |
TTBK2 |
0.722 | -0.053 | 2 | 0.509 |
MYLK4 |
0.722 | 0.077 | -2 | 0.644 |
MLK4 |
0.722 | -0.013 | 2 | 0.587 |
BMPR1A |
0.722 | 0.159 | 1 | 0.728 |
NEK9 |
0.722 | -0.113 | 2 | 0.648 |
QIK |
0.722 | 0.031 | -3 | 0.798 |
TSSK1 |
0.722 | 0.073 | -3 | 0.825 |
WNK3 |
0.721 | -0.124 | 1 | 0.667 |
PAK1 |
0.721 | 0.010 | -2 | 0.633 |
ALK2 |
0.721 | 0.106 | -2 | 0.724 |
CAMK2A |
0.721 | 0.071 | 2 | 0.567 |
MARK3 |
0.721 | 0.089 | 4 | 0.670 |
SIK |
0.721 | 0.097 | -3 | 0.762 |
CAMK2D |
0.721 | -0.012 | -3 | 0.806 |
CDK8 |
0.721 | 0.003 | 1 | 0.579 |
CK1E |
0.720 | 0.056 | -3 | 0.491 |
PASK |
0.720 | 0.189 | -3 | 0.828 |
AMPKA2 |
0.720 | 0.074 | -3 | 0.790 |
CDK13 |
0.720 | 0.028 | 1 | 0.564 |
CAMK2B |
0.720 | 0.050 | 2 | 0.554 |
CDK5 |
0.719 | 0.049 | 1 | 0.608 |
PRKX |
0.719 | 0.130 | -3 | 0.702 |
PIM2 |
0.719 | 0.112 | -3 | 0.780 |
PKACB |
0.719 | 0.079 | -2 | 0.544 |
CDK18 |
0.719 | 0.042 | 1 | 0.531 |
DYRK1A |
0.719 | 0.103 | 1 | 0.650 |
PLK1 |
0.718 | -0.042 | -2 | 0.688 |
DYRK4 |
0.718 | 0.102 | 1 | 0.571 |
PAK3 |
0.718 | -0.028 | -2 | 0.629 |
MASTL |
0.718 | -0.189 | -2 | 0.738 |
JNK3 |
0.718 | 0.062 | 1 | 0.564 |
AURC |
0.717 | 0.026 | -2 | 0.519 |
MELK |
0.717 | 0.040 | -3 | 0.787 |
TGFBR1 |
0.717 | 0.013 | -2 | 0.712 |
BRSK1 |
0.717 | 0.067 | -3 | 0.790 |
MSK1 |
0.716 | 0.079 | -3 | 0.786 |
PHKG1 |
0.716 | -0.014 | -3 | 0.799 |
CDK19 |
0.716 | 0.002 | 1 | 0.546 |
MARK2 |
0.716 | 0.057 | 4 | 0.636 |
ALK4 |
0.716 | -0.018 | -2 | 0.721 |
MNK2 |
0.716 | 0.020 | -2 | 0.654 |
ERK1 |
0.716 | 0.037 | 1 | 0.555 |
SGK3 |
0.716 | 0.069 | -3 | 0.780 |
CAMK4 |
0.716 | -0.027 | -3 | 0.787 |
ACVR2B |
0.715 | 0.042 | -2 | 0.673 |
YSK4 |
0.715 | -0.052 | 1 | 0.617 |
HIPK3 |
0.715 | 0.071 | 1 | 0.636 |
MARK1 |
0.714 | 0.076 | 4 | 0.689 |
TLK1 |
0.714 | -0.025 | -2 | 0.744 |
BRAF |
0.714 | 0.075 | -4 | 0.821 |
NEK2 |
0.714 | -0.074 | 2 | 0.633 |
MNK1 |
0.714 | 0.043 | -2 | 0.663 |
DYRK3 |
0.714 | 0.100 | 1 | 0.667 |
JNK2 |
0.714 | 0.061 | 1 | 0.529 |
PKCT |
0.714 | 0.049 | 2 | 0.609 |
ERK2 |
0.714 | 0.029 | 1 | 0.594 |
CDK2 |
0.714 | 0.007 | 1 | 0.607 |
PRP4 |
0.713 | 0.042 | -3 | 0.739 |
VRK2 |
0.713 | -0.117 | 1 | 0.743 |
SMMLCK |
0.713 | 0.065 | -3 | 0.822 |
PERK |
0.713 | -0.045 | -2 | 0.717 |
P38A |
0.713 | 0.018 | 1 | 0.631 |
CDK7 |
0.713 | -0.006 | 1 | 0.588 |
CDK12 |
0.712 | 0.022 | 1 | 0.539 |
SNRK |
0.712 | -0.063 | 2 | 0.578 |
GRK2 |
0.712 | -0.001 | -2 | 0.668 |
AKT2 |
0.712 | 0.098 | -3 | 0.742 |
AURB |
0.712 | 0.008 | -2 | 0.517 |
DYRK1B |
0.712 | 0.077 | 1 | 0.584 |
DRAK1 |
0.712 | 0.009 | 1 | 0.558 |
CDK9 |
0.712 | 0.010 | 1 | 0.568 |
CDK3 |
0.712 | 0.052 | 1 | 0.501 |
MAPKAPK5 |
0.711 | 0.018 | -3 | 0.766 |
PAK2 |
0.711 | -0.039 | -2 | 0.619 |
IRAK4 |
0.711 | 0.005 | 1 | 0.709 |
TLK2 |
0.711 | -0.060 | 1 | 0.670 |
CDK17 |
0.711 | 0.026 | 1 | 0.482 |
MEK1 |
0.710 | -0.109 | 2 | 0.618 |
PDHK3_TYR |
0.710 | 0.152 | 4 | 0.818 |
PKG2 |
0.710 | 0.014 | -2 | 0.541 |
MEKK3 |
0.710 | -0.027 | 1 | 0.642 |
ACVR2A |
0.709 | -0.018 | -2 | 0.646 |
PKCI |
0.709 | 0.047 | 2 | 0.587 |
P38B |
0.709 | 0.028 | 1 | 0.574 |
CDK10 |
0.709 | 0.081 | 1 | 0.546 |
EPHA6 |
0.708 | 0.116 | -1 | 0.725 |
P38G |
0.708 | 0.029 | 1 | 0.480 |
CHK1 |
0.708 | 0.021 | -3 | 0.779 |
PLK3 |
0.708 | -0.054 | 2 | 0.571 |
BRSK2 |
0.708 | -0.011 | -3 | 0.790 |
CK1D |
0.707 | 0.044 | -3 | 0.433 |
PKCE |
0.707 | 0.083 | 2 | 0.589 |
MEKK1 |
0.707 | -0.102 | 1 | 0.655 |
NEK5 |
0.707 | -0.024 | 1 | 0.687 |
CK1G1 |
0.707 | 0.003 | -3 | 0.506 |
MST3 |
0.707 | 0.007 | 2 | 0.657 |
CAMK1D |
0.707 | 0.111 | -3 | 0.723 |
CK2A2 |
0.707 | 0.064 | 1 | 0.598 |
DAPK3 |
0.706 | 0.098 | -3 | 0.798 |
MEK5 |
0.706 | -0.111 | 2 | 0.644 |
SMG1 |
0.706 | -0.095 | 1 | 0.620 |
PINK1 |
0.706 | -0.090 | 1 | 0.749 |
ERK7 |
0.706 | 0.026 | 2 | 0.446 |
DCAMKL1 |
0.706 | 0.062 | -3 | 0.773 |
MEKK2 |
0.706 | -0.051 | 2 | 0.634 |
GAK |
0.706 | 0.130 | 1 | 0.698 |
P70S6K |
0.706 | 0.061 | -3 | 0.756 |
MPSK1 |
0.705 | 0.030 | 1 | 0.699 |
PDHK4_TYR |
0.705 | 0.118 | 2 | 0.696 |
ZAK |
0.705 | -0.096 | 1 | 0.636 |
HRI |
0.705 | -0.135 | -2 | 0.698 |
TAO3 |
0.705 | 0.024 | 1 | 0.641 |
WNK4 |
0.705 | -0.055 | -2 | 0.756 |
PLK4 |
0.704 | -0.078 | 2 | 0.476 |
TESK1_TYR |
0.704 | 0.026 | 3 | 0.731 |
AKT1 |
0.703 | 0.077 | -3 | 0.740 |
PDHK1_TYR |
0.703 | 0.065 | -1 | 0.711 |
MAP2K6_TYR |
0.703 | 0.051 | -1 | 0.689 |
MST2 |
0.703 | 0.037 | 1 | 0.641 |
PAK6 |
0.702 | -0.042 | -2 | 0.533 |
SSTK |
0.702 | 0.024 | 4 | 0.705 |
GSK3A |
0.702 | 0.017 | 4 | 0.408 |
PKACA |
0.702 | 0.059 | -2 | 0.487 |
CDK14 |
0.702 | 0.014 | 1 | 0.557 |
DCAMKL2 |
0.701 | 0.019 | -3 | 0.788 |
CDK16 |
0.701 | 0.021 | 1 | 0.497 |
NEK8 |
0.701 | -0.030 | 2 | 0.658 |
BMPR2_TYR |
0.701 | 0.023 | -1 | 0.691 |
EEF2K |
0.701 | 0.059 | 3 | 0.740 |
EPHB4 |
0.700 | 0.057 | -1 | 0.701 |
NEK11 |
0.700 | -0.053 | 1 | 0.619 |
PKMYT1_TYR |
0.699 | -0.060 | 3 | 0.720 |
PINK1_TYR |
0.699 | -0.024 | 1 | 0.707 |
MAP2K4_TYR |
0.699 | -0.039 | -1 | 0.681 |
MAK |
0.699 | 0.131 | -2 | 0.630 |
AURA |
0.699 | -0.034 | -2 | 0.491 |
GRK3 |
0.699 | -0.003 | -2 | 0.650 |
MOK |
0.699 | 0.128 | 1 | 0.704 |
CHK2 |
0.699 | 0.112 | -3 | 0.695 |
CAMKK1 |
0.699 | -0.076 | -2 | 0.656 |
CK1A2 |
0.699 | 0.004 | -3 | 0.440 |
DNAPK |
0.699 | -0.093 | 1 | 0.506 |
LRRK2 |
0.699 | 0.050 | 2 | 0.656 |
STK33 |
0.698 | -0.020 | 2 | 0.479 |
MAP2K7_TYR |
0.698 | -0.094 | 2 | 0.663 |
PHKG2 |
0.698 | -0.024 | -3 | 0.775 |
LIMK2_TYR |
0.697 | 0.013 | -3 | 0.813 |
TAO2 |
0.697 | -0.033 | 2 | 0.671 |
JNK1 |
0.697 | 0.046 | 1 | 0.514 |
DAPK1 |
0.697 | 0.071 | -3 | 0.796 |
EPHA4 |
0.697 | 0.083 | 2 | 0.585 |
TNIK |
0.696 | 0.030 | 3 | 0.750 |
TXK |
0.696 | 0.111 | 1 | 0.683 |
CAMKK2 |
0.696 | -0.036 | -2 | 0.649 |
TTBK1 |
0.696 | -0.107 | 2 | 0.450 |
GCK |
0.696 | 0.031 | 1 | 0.631 |
LKB1 |
0.695 | -0.007 | -3 | 0.747 |
ROCK2 |
0.695 | 0.104 | -3 | 0.787 |
P38D |
0.695 | 0.015 | 1 | 0.489 |
CAMK1A |
0.695 | 0.099 | -3 | 0.694 |
BLK |
0.695 | 0.108 | -1 | 0.680 |
GSK3B |
0.695 | -0.030 | 4 | 0.394 |
TAK1 |
0.695 | 0.018 | 1 | 0.680 |
PKN1 |
0.695 | 0.035 | -3 | 0.759 |
MEKK6 |
0.694 | -0.055 | 1 | 0.672 |
MST1 |
0.694 | 0.040 | 1 | 0.630 |
CDK4 |
0.694 | 0.037 | 1 | 0.530 |
MRCKB |
0.694 | 0.083 | -3 | 0.757 |
CDK6 |
0.694 | 0.031 | 1 | 0.538 |
RET |
0.694 | -0.080 | 1 | 0.665 |
HGK |
0.693 | -0.008 | 3 | 0.744 |
TNK2 |
0.693 | 0.050 | 3 | 0.674 |
LIMK1_TYR |
0.693 | -0.067 | 2 | 0.655 |
TYRO3 |
0.693 | -0.036 | 3 | 0.688 |
CK2A1 |
0.693 | 0.028 | 1 | 0.566 |
MST1R |
0.693 | -0.072 | 3 | 0.719 |
CSF1R |
0.693 | -0.045 | 3 | 0.688 |
SLK |
0.692 | 0.052 | -2 | 0.624 |
TEC |
0.692 | 0.089 | -1 | 0.617 |
ABL2 |
0.692 | 0.000 | -1 | 0.672 |
SGK1 |
0.692 | 0.098 | -3 | 0.690 |
MRCKA |
0.692 | 0.082 | -3 | 0.768 |
MINK |
0.692 | -0.023 | 1 | 0.641 |
AKT3 |
0.691 | 0.084 | -3 | 0.696 |
EPHB2 |
0.691 | 0.066 | -1 | 0.686 |
JAK3 |
0.691 | -0.053 | 1 | 0.636 |
MAP3K15 |
0.691 | -0.061 | 1 | 0.614 |
DDR1 |
0.691 | -0.052 | 4 | 0.757 |
PDK1 |
0.691 | -0.049 | 1 | 0.632 |
ROS1 |
0.691 | -0.091 | 3 | 0.657 |
SRMS |
0.690 | 0.072 | 1 | 0.724 |
NEK4 |
0.690 | -0.113 | 1 | 0.648 |
LCK |
0.690 | 0.057 | -1 | 0.664 |
EPHB3 |
0.690 | 0.034 | -1 | 0.699 |
INSRR |
0.690 | -0.035 | 3 | 0.638 |
PLK2 |
0.690 | -0.004 | -3 | 0.770 |
TTK |
0.690 | 0.033 | -2 | 0.713 |
IRAK1 |
0.690 | -0.189 | -1 | 0.572 |
VRK1 |
0.690 | -0.059 | 2 | 0.632 |
FER |
0.690 | 0.006 | 1 | 0.739 |
EPHB1 |
0.689 | 0.027 | 1 | 0.716 |
HPK1 |
0.689 | -0.007 | 1 | 0.615 |
YES1 |
0.689 | 0.004 | -1 | 0.675 |
LOK |
0.689 | -0.019 | -2 | 0.652 |
KHS2 |
0.689 | 0.060 | 1 | 0.629 |
MET |
0.689 | 0.001 | 3 | 0.686 |
KIT |
0.688 | -0.039 | 3 | 0.692 |
HCK |
0.688 | -0.006 | -1 | 0.659 |
TYK2 |
0.688 | -0.165 | 1 | 0.666 |
FGR |
0.688 | -0.045 | 1 | 0.692 |
EPHA7 |
0.688 | 0.039 | 2 | 0.600 |
ITK |
0.687 | 0.023 | -1 | 0.632 |
KHS1 |
0.687 | 0.014 | 1 | 0.625 |
ABL1 |
0.687 | -0.020 | -1 | 0.665 |
SBK |
0.686 | 0.107 | -3 | 0.644 |
ALPHAK3 |
0.686 | 0.120 | -1 | 0.642 |
FGFR2 |
0.686 | -0.074 | 3 | 0.671 |
FRK |
0.685 | 0.031 | -1 | 0.686 |
ROCK1 |
0.685 | 0.083 | -3 | 0.766 |
KDR |
0.685 | -0.068 | 3 | 0.657 |
PAK5 |
0.685 | -0.059 | -2 | 0.489 |
HASPIN |
0.685 | 0.023 | -1 | 0.525 |
PDGFRB |
0.685 | -0.104 | 3 | 0.700 |
EPHA5 |
0.685 | 0.067 | 2 | 0.594 |
JAK2 |
0.685 | -0.170 | 1 | 0.661 |
FYN |
0.685 | 0.060 | -1 | 0.641 |
NEK1 |
0.684 | -0.089 | 1 | 0.669 |
BMX |
0.684 | 0.023 | -1 | 0.597 |
FLT3 |
0.684 | -0.065 | 3 | 0.703 |
PAK4 |
0.684 | -0.059 | -2 | 0.498 |
EPHA3 |
0.684 | -0.021 | 2 | 0.573 |
EPHA8 |
0.683 | 0.024 | -1 | 0.695 |
WEE1_TYR |
0.683 | -0.021 | -1 | 0.589 |
MATK |
0.682 | -0.020 | -1 | 0.625 |
TEK |
0.682 | -0.059 | 3 | 0.629 |
DMPK1 |
0.682 | 0.083 | -3 | 0.763 |
OSR1 |
0.682 | -0.024 | 2 | 0.622 |
YSK1 |
0.682 | -0.068 | 2 | 0.635 |
BUB1 |
0.682 | 0.028 | -5 | 0.619 |
DDR2 |
0.682 | 0.000 | 3 | 0.633 |
AXL |
0.681 | -0.049 | 3 | 0.664 |
SYK |
0.681 | 0.106 | -1 | 0.633 |
TNNI3K_TYR |
0.681 | -0.056 | 1 | 0.712 |
MERTK |
0.681 | -0.037 | 3 | 0.658 |
RIPK2 |
0.680 | -0.176 | 1 | 0.572 |
TNK1 |
0.680 | -0.061 | 3 | 0.665 |
FGFR1 |
0.680 | -0.099 | 3 | 0.661 |
EPHA1 |
0.680 | -0.028 | 3 | 0.679 |
FLT1 |
0.680 | -0.055 | -1 | 0.673 |
LTK |
0.680 | -0.065 | 3 | 0.641 |
FGFR3 |
0.679 | -0.061 | 3 | 0.657 |
LYN |
0.679 | 0.005 | 3 | 0.637 |
ALK |
0.678 | -0.088 | 3 | 0.628 |
PTK2 |
0.678 | 0.044 | -1 | 0.640 |
PTK2B |
0.678 | 0.016 | -1 | 0.641 |
PTK6 |
0.677 | -0.091 | -1 | 0.581 |
PBK |
0.677 | -0.039 | 1 | 0.624 |
ERBB2 |
0.676 | -0.084 | 1 | 0.610 |
BTK |
0.676 | -0.075 | -1 | 0.600 |
PDGFRA |
0.676 | -0.167 | 3 | 0.698 |
NTRK1 |
0.676 | -0.121 | -1 | 0.650 |
MYO3B |
0.675 | -0.032 | 2 | 0.640 |
PKG1 |
0.675 | -0.001 | -2 | 0.438 |
FLT4 |
0.675 | -0.114 | 3 | 0.637 |
JAK1 |
0.674 | -0.139 | 1 | 0.585 |
SRC |
0.674 | 0.004 | -1 | 0.655 |
NTRK2 |
0.674 | -0.128 | 3 | 0.670 |
CK1A |
0.674 | 0.005 | -3 | 0.354 |
NEK10_TYR |
0.673 | -0.110 | 1 | 0.547 |
NTRK3 |
0.673 | -0.093 | -1 | 0.623 |
NEK3 |
0.673 | -0.153 | 1 | 0.620 |
EPHA2 |
0.673 | 0.006 | -1 | 0.656 |
INSR |
0.673 | -0.116 | 3 | 0.636 |
MYO3A |
0.672 | -0.049 | 1 | 0.665 |
CRIK |
0.671 | 0.079 | -3 | 0.738 |
EGFR |
0.671 | -0.042 | 1 | 0.529 |
MEK2 |
0.671 | -0.222 | 2 | 0.599 |
YANK3 |
0.668 | -0.056 | 2 | 0.287 |
ASK1 |
0.668 | -0.112 | 1 | 0.605 |
FGFR4 |
0.667 | -0.060 | -1 | 0.633 |
TAO1 |
0.666 | -0.081 | 1 | 0.577 |
BIKE |
0.666 | -0.018 | 1 | 0.580 |
ERBB4 |
0.666 | -0.013 | 1 | 0.554 |
CSK |
0.665 | -0.097 | 2 | 0.592 |
IGF1R |
0.663 | -0.097 | 3 | 0.581 |
MUSK |
0.661 | -0.113 | 1 | 0.521 |
CK1G3 |
0.660 | 0.021 | -3 | 0.309 |
STLK3 |
0.656 | -0.150 | 1 | 0.597 |
ZAP70 |
0.655 | -0.003 | -1 | 0.584 |
FES |
0.655 | -0.049 | -1 | 0.583 |
CK1G2 |
0.649 | 0.029 | -3 | 0.406 |
AAK1 |
0.647 | -0.010 | 1 | 0.499 |
YANK2 |
0.639 | -0.075 | 2 | 0.302 |