Motif 643 (n=105)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
B5ME19 | EIF3CL | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
F8WAN1 | SPECC1L-ADORA2A | S226 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
O15061 | SYNM | S633 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15527 | OGG1 | S232 | psp | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
O43290 | SART1 | S591 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
O60264 | SMARCA5 | S710 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
O75164 | KDM4A | S621 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
O75410 | TACC1 | S248 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
O94782 | USP1 | S466 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
O95071 | UBR5 | S1990 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
O95613 | PCNT | S813 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
O95749 | GGPS1 | S203 | ochoa | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. {ECO:0000269|PubMed:32403198}. |
O95801 | TTC4 | S243 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
P02549 | SPTA1 | S1284 | ochoa | Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
P04350 | TUBB4A | S78 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P07437 | TUBB | S78 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0DJ93 | SMIM13 | S58 | ochoa | Small integral membrane protein 13 | None |
P11055 | MYH3 | Y1376 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
P11137 | MAP2 | S1398 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P12270 | TPR | S829 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
P12882 | MYH1 | Y1379 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12882 | MYH1 | S1702 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | Y1375 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12883 | MYH7 | S1463 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12883 | MYH7 | S1698 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | Y1377 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13533 | MYH6 | S1465 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13533 | MYH6 | S1700 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | Y1378 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P15374 | UCHL3 | S151 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
P20393 | NR1D1 | S442 | ochoa | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
P24539 | ATP5PB | S155 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
P28370 | SMARCA1 | S725 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) | [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}. |
P28715 | ERCC5 | S724 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
P35749 | MYH11 | S1291 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P45974 | USP5 | S149 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
P68363 | TUBA1B | T80 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
P68371 | TUBB4B | S78 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q00610 | CLTC | S1462 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Q01196 | RUNX1 | S193 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
Q02880 | TOP2B | S1279 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
Q04721 | NOTCH2 | S1854 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
Q13523 | PRP4K | S23 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
Q13885 | TUBB2A | S78 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14151 | SAFB2 | S207 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14739 | LBR | S130 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
Q15075 | EEA1 | S98 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
Q15075 | EEA1 | S359 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
Q15149 | PLEC | S3143 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q69YQ0 | SPECC1L | S226 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
Q6NSJ2 | PHLDB3 | S63 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
Q6ZMW3 | EML6 | S1284 | ochoa | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}. |
Q70Z53 | FRA10AC1 | S283 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
Q71U36 | TUBA1A | T80 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q7Z5K2 | WAPL | S130 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
Q7Z736 | PLEKHH3 | S30 | ochoa | Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) | None |
Q86SQ0 | PHLDB2 | S493 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86UP2 | KTN1 | S1310 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
Q86V15 | CASZ1 | S1722 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
Q86V48 | LUZP1 | S57 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
Q86WN1 | FCHSD1 | S444 | ochoa | F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) | Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}. |
Q86XI2 | NCAPG2 | S30 | ochoa | Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:30609410}. |
Q8IWS0 | PHF6 | S145 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
Q8IY92 | SLX4 | S1204 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
Q8IZD0 | SAMD14 | S64 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
Q8N4S0 | CCDC82 | S219 | ochoa | Coiled-coil domain-containing protein 82 | None |
Q8N8J7 | FAM241A | S56 | ochoa | Uncharacterized protein FAM241A | None |
Q8TBZ6 | TRMT10A | S28 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
Q8WWI1 | LMO7 | S751 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q96L73 | NSD1 | S486 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Q96T23 | RSF1 | S1310 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
Q99613 | EIF3C | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
Q9BQE3 | TUBA1C | T80 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9BVA1 | TUBB2B | S78 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9BVS4 | RIOK2 | Y348 | psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
Q9BXL6 | CARD14 | S290 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
Q9H211 | CDT1 | S150 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
Q9H6N6 | MYH16 | Y538 | ochoa | Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) | Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303|PubMed:15042088}. |
Q9H9A6 | LRRC40 | S375 | ochoa | Leucine-rich repeat-containing protein 40 | None |
Q9NR30 | DDX21 | S171 | ochoa|psp | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
Q9NU22 | MDN1 | S4752 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
Q9NW75 | GPATCH2 | S284 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
Q9NZN5 | ARHGEF12 | S1273 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
Q9UKA4 | AKAP11 | S1493 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
Q9UKE5 | TNIK | S996 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
Q9UKX2 | MYH2 | Y1381 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX2 | MYH2 | S1704 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX3 | MYH13 | Y1379 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
Q9UNF0 | PACSIN2 | S446 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
Q9UQE7 | SMC3 | S1065 | ochoa|psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
Q9UQR1 | ZNF148 | S415 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
Q9Y3T9 | NOC2L | S635 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
Q9Y623 | MYH4 | Y1379 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
Q9Y6D9 | MAD1L1 | S490 | ochoa | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
Q9Y6J0 | CABIN1 | S20 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
Q9Y6K1 | DNMT3A | S393 | psp | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
R4GMW8 | BIVM-ERCC5 | S1178 | ochoa | DNA excision repair protein ERCC-5 | None |
P0DPH7 | TUBA3C | T80 | Sugiyama | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q6PEY2 | TUBA3E | T80 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P05787 | KRT8 | S274 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
P18206 | VCL | S1101 | GPS6|SIGNOR|ELM|EPSD | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
O15226 | NKRF | S532 | Sugiyama | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
Q9BSV6 | TSEN34 | S93 | Sugiyama | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
Q6UB35 | MTHFD1L | S366 | Sugiyama | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
Q9Y5S2 | CDC42BPB | S437 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-15 | 14.955 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 1.776357e-15 | 14.750 |
R-HSA-9646399 | Aggrephagy | 5.240253e-14 | 13.281 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 8.193446e-14 | 13.087 |
R-HSA-190828 | Gap junction trafficking | 1.549871e-13 | 12.810 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.493561e-13 | 12.603 |
R-HSA-437239 | Recycling pathway of L1 | 2.822187e-13 | 12.549 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.138600e-13 | 12.503 |
R-HSA-157858 | Gap junction trafficking and regulation | 4.132250e-13 | 12.384 |
R-HSA-190861 | Gap junction assembly | 5.117018e-13 | 12.291 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.249889e-12 | 11.903 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.904676e-12 | 11.537 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.777601e-12 | 11.238 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.926659e-12 | 11.101 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 8.907430e-12 | 11.050 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.586342e-11 | 10.800 |
R-HSA-68877 | Mitotic Prometaphase | 2.919875e-11 | 10.535 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.307621e-11 | 10.480 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.106060e-11 | 10.387 |
R-HSA-983189 | Kinesins | 6.897460e-11 | 10.161 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.111223e-11 | 10.040 |
R-HSA-9663891 | Selective autophagy | 1.137892e-10 | 9.944 |
R-HSA-373760 | L1CAM interactions | 1.604911e-10 | 9.795 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.003177e-10 | 9.698 |
R-HSA-2132295 | MHC class II antigen presentation | 2.892683e-10 | 9.539 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.899664e-10 | 9.538 |
R-HSA-6807878 | COPI-mediated anterograde transport | 3.161006e-10 | 9.500 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.680632e-10 | 9.434 |
R-HSA-68886 | M Phase | 4.443106e-10 | 9.352 |
R-HSA-2467813 | Separation of Sister Chromatids | 5.887943e-10 | 9.230 |
R-HSA-9833482 | PKR-mediated signaling | 8.098096e-10 | 9.092 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.127784e-09 | 8.948 |
R-HSA-68882 | Mitotic Anaphase | 1.319548e-09 | 8.880 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.392033e-09 | 8.856 |
R-HSA-438064 | Post NMDA receptor activation events | 1.846076e-09 | 8.734 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.886522e-09 | 8.724 |
R-HSA-69278 | Cell Cycle, Mitotic | 4.398350e-09 | 8.357 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.126817e-09 | 8.290 |
R-HSA-1640170 | Cell Cycle | 5.998286e-09 | 8.222 |
R-HSA-5620924 | Intraflagellar transport | 7.376336e-09 | 8.132 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.546320e-09 | 8.068 |
R-HSA-1632852 | Macroautophagy | 1.714912e-08 | 7.766 |
R-HSA-69275 | G2/M Transition | 2.464950e-08 | 7.608 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 2.653501e-08 | 7.576 |
R-HSA-453274 | Mitotic G2-G2/M phases | 2.737827e-08 | 7.563 |
R-HSA-390466 | Chaperonin-mediated protein folding | 3.007783e-08 | 7.522 |
R-HSA-5617833 | Cilium Assembly | 3.037507e-08 | 7.517 |
R-HSA-9612973 | Autophagy | 4.518689e-08 | 7.345 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.025218e-08 | 7.395 |
R-HSA-391251 | Protein folding | 5.014337e-08 | 7.300 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.037571e-07 | 6.984 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 1.206692e-07 | 6.918 |
R-HSA-9609690 | HCMV Early Events | 3.657251e-07 | 6.437 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.782152e-07 | 6.320 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.192036e-06 | 5.924 |
R-HSA-5610787 | Hedgehog 'off' state | 1.282382e-06 | 5.892 |
R-HSA-9609646 | HCMV Infection | 3.262834e-06 | 5.486 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.468533e-06 | 5.460 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.728633e-06 | 5.242 |
R-HSA-5358351 | Signaling by Hedgehog | 1.441127e-05 | 4.841 |
R-HSA-422475 | Axon guidance | 4.128391e-05 | 4.384 |
R-HSA-9675108 | Nervous system development | 8.093270e-05 | 4.092 |
R-HSA-913531 | Interferon Signaling | 1.267899e-04 | 3.897 |
R-HSA-112315 | Transmission across Chemical Synapses | 1.508097e-04 | 3.822 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.511078e-04 | 3.821 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.511078e-04 | 3.821 |
R-HSA-8854518 | AURKA Activation by TPX2 | 1.828093e-04 | 3.738 |
R-HSA-9656249 | Defective Base Excision Repair Associated with OGG1 | 2.128194e-04 | 3.672 |
R-HSA-199991 | Membrane Trafficking | 2.367051e-04 | 3.626 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.764263e-04 | 3.558 |
R-HSA-446203 | Asparagine N-linked glycosylation | 2.790159e-04 | 3.554 |
R-HSA-380287 | Centrosome maturation | 3.088731e-04 | 3.510 |
R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 3.766297e-04 | 3.424 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.919293e-04 | 3.308 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.831116e-04 | 3.166 |
R-HSA-9605308 | Diseases of Base Excision Repair | 1.479409e-03 | 2.830 |
R-HSA-5653656 | Vesicle-mediated transport | 1.889597e-03 | 2.724 |
R-HSA-112316 | Neuronal System | 2.259002e-03 | 2.646 |
R-HSA-2262752 | Cellular responses to stress | 2.278251e-03 | 2.642 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 2.290717e-03 | 2.640 |
R-HSA-390522 | Striated Muscle Contraction | 2.854769e-03 | 2.544 |
R-HSA-8953897 | Cellular responses to stimuli | 2.918320e-03 | 2.535 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 3.819097e-03 | 2.418 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 5.038835e-03 | 2.298 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.427856e-03 | 2.265 |
R-HSA-9656255 | Defective OGG1 Substrate Binding | 6.931309e-03 | 2.159 |
R-HSA-9657050 | Defective OGG1 Localization | 6.931309e-03 | 2.159 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.850567e-03 | 2.007 |
R-HSA-9700206 | Signaling by ALK in cancer | 9.850567e-03 | 2.007 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.162141e-02 | 1.935 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.338009e-02 | 1.874 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.367614e-02 | 1.864 |
R-HSA-9656256 | Defective OGG1 Substrate Processing | 1.381500e-02 | 1.860 |
R-HSA-73894 | DNA Repair | 1.724817e-02 | 1.763 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.871002e-02 | 1.728 |
R-HSA-400685 | Sema4D in semaphorin signaling | 2.002684e-02 | 1.698 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.124440e-02 | 1.673 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.124440e-02 | 1.673 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.249204e-02 | 1.648 |
R-HSA-191273 | Cholesterol biosynthesis | 2.256365e-02 | 1.647 |
R-HSA-597592 | Post-translational protein modification | 2.288258e-02 | 1.640 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.324480e-02 | 1.634 |
R-HSA-397014 | Muscle contraction | 2.347107e-02 | 1.629 |
R-HSA-109582 | Hemostasis | 2.479330e-02 | 1.606 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.641082e-02 | 1.578 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.350111e-02 | 1.475 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.652262e-02 | 1.437 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.916531e-02 | 1.535 |
R-HSA-69205 | G1/S-Specific Transcription | 3.652262e-02 | 1.437 |
R-HSA-1280218 | Adaptive Immune System | 3.451616e-02 | 1.462 |
R-HSA-9824446 | Viral Infection Pathways | 2.846690e-02 | 1.546 |
R-HSA-73927 | Depurination | 3.964494e-02 | 1.402 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.010011e-02 | 1.397 |
R-HSA-5083630 | Defective LFNG causes SCDO3 | 4.088005e-02 | 1.388 |
R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 4.088005e-02 | 1.388 |
R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 4.753047e-02 | 1.323 |
R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 4.753047e-02 | 1.323 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.787033e-02 | 1.320 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.186949e-02 | 1.285 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.307737e-02 | 1.275 |
R-HSA-774815 | Nucleosome assembly | 5.307737e-02 | 1.275 |
R-HSA-6783310 | Fanconi Anemia Pathway | 5.307737e-02 | 1.275 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 5.413519e-02 | 1.267 |
R-HSA-9675135 | Diseases of DNA repair | 5.485605e-02 | 1.261 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 6.069452e-02 | 1.217 |
R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 6.720877e-02 | 1.173 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 7.367823e-02 | 1.133 |
R-HSA-446107 | Type I hemidesmosome assembly | 7.367823e-02 | 1.133 |
R-HSA-196025 | Formation of annular gap junctions | 7.367823e-02 | 1.133 |
R-HSA-190873 | Gap junction degradation | 8.010323e-02 | 1.096 |
R-HSA-9700645 | ALK mutants bind TKIs | 8.010323e-02 | 1.096 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 9.911441e-02 | 1.004 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.787074e-02 | 1.168 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 6.720877e-02 | 1.173 |
R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 7.367823e-02 | 1.133 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 8.648406e-02 | 1.063 |
R-HSA-9707616 | Heme signaling | 8.591167e-02 | 1.066 |
R-HSA-6784531 | tRNA processing in the nucleus | 8.591167e-02 | 1.066 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.974766e-02 | 1.098 |
R-HSA-445355 | Smooth Muscle Contraction | 6.787074e-02 | 1.168 |
R-HSA-5693606 | DNA Double Strand Break Response | 9.648961e-02 | 1.016 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 6.720877e-02 | 1.173 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 8.010323e-02 | 1.096 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.010323e-02 | 1.096 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.980627e-02 | 1.156 |
R-HSA-373755 | Semaphorin interactions | 8.799762e-02 | 1.056 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.052044e-01 | 0.978 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.053645e-01 | 0.977 |
R-HSA-8866427 | VLDLR internalisation and degradation | 1.053645e-01 | 0.977 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.053645e-01 | 0.977 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.074158e-01 | 0.969 |
R-HSA-157118 | Signaling by NOTCH | 1.084795e-01 | 0.965 |
R-HSA-69242 | S Phase | 1.098879e-01 | 0.959 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.115717e-01 | 0.952 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.115717e-01 | 0.952 |
R-HSA-8852135 | Protein ubiquitination | 1.141237e-01 | 0.943 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 1.172734e-01 | 0.931 |
R-HSA-177504 | Retrograde neurotrophin signalling | 1.177361e-01 | 0.929 |
R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.299381e-01 | 0.886 |
R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.538426e-01 | 0.813 |
R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 1.597163e-01 | 0.797 |
R-HSA-9615710 | Late endosomal microautophagy | 2.162756e-01 | 0.665 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.217196e-01 | 0.654 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.271262e-01 | 0.644 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.271262e-01 | 0.644 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.378278e-01 | 0.624 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.378278e-01 | 0.624 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.378278e-01 | 0.624 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.431235e-01 | 0.614 |
R-HSA-5696400 | Dual Incision in GG-NER | 2.483826e-01 | 0.605 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.536056e-01 | 0.596 |
R-HSA-1980145 | Signaling by NOTCH2 | 2.483826e-01 | 0.605 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.655496e-01 | 0.781 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.359763e-01 | 0.867 |
R-HSA-350054 | Notch-HLH transcription pathway | 1.770961e-01 | 0.752 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.884842e-01 | 0.725 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 2.052741e-01 | 0.688 |
R-HSA-8949613 | Cristae formation | 2.052741e-01 | 0.688 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.162756e-01 | 0.665 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 1.479283e-01 | 0.830 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.299381e-01 | 0.886 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.431235e-01 | 0.614 |
R-HSA-68962 | Activation of the pre-replicative complex | 2.217196e-01 | 0.654 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.713428e-01 | 0.766 |
R-HSA-5334118 | DNA methylation | 2.162756e-01 | 0.665 |
R-HSA-180746 | Nuclear import of Rev protein | 2.483826e-01 | 0.605 |
R-HSA-68875 | Mitotic Prophase | 2.391386e-01 | 0.621 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.052741e-01 | 0.688 |
R-HSA-3214842 | HDMs demethylate histones | 1.941195e-01 | 0.712 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.378278e-01 | 0.624 |
R-HSA-5693537 | Resolution of D-Loop Structures | 2.431235e-01 | 0.614 |
R-HSA-8964038 | LDL clearance | 1.770961e-01 | 0.752 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.655496e-01 | 0.781 |
R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 1.770961e-01 | 0.752 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.378278e-01 | 0.624 |
R-HSA-392499 | Metabolism of proteins | 2.412427e-01 | 0.618 |
R-HSA-73884 | Base Excision Repair | 1.515065e-01 | 0.820 |
R-HSA-9945266 | Differentiation of T cells | 1.299381e-01 | 0.886 |
R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.299381e-01 | 0.886 |
R-HSA-1592230 | Mitochondrial biogenesis | 2.314589e-01 | 0.636 |
R-HSA-72306 | tRNA processing | 1.453030e-01 | 0.838 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.858908e-01 | 0.731 |
R-HSA-1266738 | Developmental Biology | 1.367504e-01 | 0.864 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.483826e-01 | 0.605 |
R-HSA-2559583 | Cellular Senescence | 1.617446e-01 | 0.791 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.536056e-01 | 0.596 |
R-HSA-162582 | Signal Transduction | 2.107770e-01 | 0.676 |
R-HSA-2682334 | EPH-Ephrin signaling | 1.587662e-01 | 0.799 |
R-HSA-8957322 | Metabolism of steroids | 2.183461e-01 | 0.661 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.324955e-01 | 0.634 |
R-HSA-73886 | Chromosome Maintenance | 2.417016e-01 | 0.617 |
R-HSA-5663205 | Infectious disease | 2.088703e-01 | 0.680 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 1.403338e-01 | 0.853 |
R-HSA-69206 | G1/S Transition | 2.545340e-01 | 0.594 |
R-HSA-212300 | PRC2 methylates histones and DNA | 2.587925e-01 | 0.587 |
R-HSA-3247509 | Chromatin modifying enzymes | 2.599567e-01 | 0.585 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.639438e-01 | 0.578 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.639438e-01 | 0.578 |
R-HSA-110331 | Cleavage of the damaged purine | 2.639438e-01 | 0.578 |
R-HSA-549127 | SLC-mediated transport of organic cations | 2.639438e-01 | 0.578 |
R-HSA-196757 | Metabolism of folate and pterines | 2.639438e-01 | 0.578 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.690596e-01 | 0.570 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.741401e-01 | 0.562 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.741401e-01 | 0.562 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.741401e-01 | 0.562 |
R-HSA-8964043 | Plasma lipoprotein clearance | 2.741401e-01 | 0.562 |
R-HSA-9909396 | Circadian clock | 2.750929e-01 | 0.561 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.791856e-01 | 0.554 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.791856e-01 | 0.554 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.791856e-01 | 0.554 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.791856e-01 | 0.554 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.841964e-01 | 0.546 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.841964e-01 | 0.546 |
R-HSA-3214841 | PKMTs methylate histone lysines | 2.841964e-01 | 0.546 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.841964e-01 | 0.546 |
R-HSA-9018519 | Estrogen-dependent gene expression | 2.879348e-01 | 0.541 |
R-HSA-4839726 | Chromatin organization | 2.881441e-01 | 0.540 |
R-HSA-5674135 | MAP2K and MAPK activation | 2.891726e-01 | 0.539 |
R-HSA-9656223 | Signaling by RAF1 mutants | 2.891726e-01 | 0.539 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.941146e-01 | 0.531 |
R-HSA-73928 | Depyrimidination | 2.941146e-01 | 0.531 |
R-HSA-9710421 | Defective pyroptosis | 2.990224e-01 | 0.524 |
R-HSA-3214858 | RMTs methylate histone arginines | 3.038965e-01 | 0.517 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 3.084283e-01 | 0.511 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.087370e-01 | 0.510 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.135441e-01 | 0.504 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.135441e-01 | 0.504 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.135441e-01 | 0.504 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 3.135441e-01 | 0.504 |
R-HSA-6802949 | Signaling by RAS mutants | 3.135441e-01 | 0.504 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.135441e-01 | 0.504 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.135441e-01 | 0.504 |
R-HSA-75153 | Apoptotic execution phase | 3.135441e-01 | 0.504 |
R-HSA-9734767 | Developmental Cell Lineages | 3.146683e-01 | 0.502 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.160871e-01 | 0.500 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.183181e-01 | 0.497 |
R-HSA-73893 | DNA Damage Bypass | 3.277676e-01 | 0.484 |
R-HSA-68949 | Orc1 removal from chromatin | 3.416990e-01 | 0.466 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.416990e-01 | 0.466 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.450561e-01 | 0.462 |
R-HSA-1221632 | Meiotic synapsis | 3.462788e-01 | 0.461 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.462788e-01 | 0.461 |
R-HSA-72649 | Translation initiation complex formation | 3.508272e-01 | 0.455 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.598299e-01 | 0.444 |
R-HSA-193648 | NRAGE signals death through JNK | 3.598299e-01 | 0.444 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 3.642848e-01 | 0.439 |
R-HSA-9764561 | Regulation of CDH1 Function | 3.642848e-01 | 0.439 |
R-HSA-6782135 | Dual incision in TC-NER | 3.687089e-01 | 0.433 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.687089e-01 | 0.433 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.687089e-01 | 0.433 |
R-HSA-191859 | snRNP Assembly | 3.731025e-01 | 0.428 |
R-HSA-194441 | Metabolism of non-coding RNA | 3.731025e-01 | 0.428 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.731025e-01 | 0.428 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.774658e-01 | 0.423 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.789728e-01 | 0.421 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 3.817990e-01 | 0.418 |
R-HSA-8953854 | Metabolism of RNA | 3.860103e-01 | 0.413 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 3.861024e-01 | 0.413 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.861024e-01 | 0.413 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.861024e-01 | 0.413 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.988350e-01 | 0.399 |
R-HSA-168255 | Influenza Infection | 4.010573e-01 | 0.397 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.030208e-01 | 0.395 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.071776e-01 | 0.390 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.113058e-01 | 0.386 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.227744e-01 | 0.374 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.235203e-01 | 0.373 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.235203e-01 | 0.373 |
R-HSA-1643685 | Disease | 4.259569e-01 | 0.371 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.275356e-01 | 0.369 |
R-HSA-212165 | Epigenetic regulation of gene expression | 4.276196e-01 | 0.369 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.315233e-01 | 0.365 |
R-HSA-69052 | Switching of origins to a post-replicative state | 4.315233e-01 | 0.365 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.315233e-01 | 0.365 |
R-HSA-9013694 | Signaling by NOTCH4 | 4.354834e-01 | 0.361 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 4.370301e-01 | 0.359 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.394162e-01 | 0.357 |
R-HSA-1169408 | ISG15 antiviral mechanism | 4.394162e-01 | 0.357 |
R-HSA-5689603 | UCH proteinases | 4.433219e-01 | 0.353 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.472006e-01 | 0.349 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 4.510524e-01 | 0.346 |
R-HSA-416482 | G alpha (12/13) signalling events | 4.510524e-01 | 0.346 |
R-HSA-4086400 | PCP/CE pathway | 4.510524e-01 | 0.346 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.586766e-01 | 0.338 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.586766e-01 | 0.338 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.624492e-01 | 0.335 |
R-HSA-72172 | mRNA Splicing | 4.626678e-01 | 0.335 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.661958e-01 | 0.331 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.736114e-01 | 0.325 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.736114e-01 | 0.325 |
R-HSA-6802957 | Oncogenic MAPK signaling | 4.772809e-01 | 0.321 |
R-HSA-1500620 | Meiosis | 4.772809e-01 | 0.321 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.809250e-01 | 0.318 |
R-HSA-141424 | Amplification of signal from the kinetochores | 4.809250e-01 | 0.318 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.845439e-01 | 0.315 |
R-HSA-9645723 | Diseases of programmed cell death | 4.917069e-01 | 0.308 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 4.994547e-01 | 0.302 |
R-HSA-8951664 | Neddylation | 5.009288e-01 | 0.300 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.022668e-01 | 0.299 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.091857e-01 | 0.293 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.118505e-01 | 0.291 |
R-HSA-68867 | Assembly of the pre-replicative complex | 5.126093e-01 | 0.290 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.142349e-01 | 0.289 |
R-HSA-1474290 | Collagen formation | 5.160092e-01 | 0.287 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 5.227387e-01 | 0.282 |
R-HSA-72312 | rRNA processing | 5.247508e-01 | 0.280 |
R-HSA-8957275 | Post-translational protein phosphorylation | 5.326595e-01 | 0.274 |
R-HSA-8939211 | ESR-mediated signaling | 5.353270e-01 | 0.271 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.359207e-01 | 0.271 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 5.391595e-01 | 0.268 |
R-HSA-70171 | Glycolysis | 5.391595e-01 | 0.268 |
R-HSA-9842860 | Regulation of endogenous retroelements | 5.455699e-01 | 0.263 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.455699e-01 | 0.263 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.518919e-01 | 0.258 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 5.518919e-01 | 0.258 |
R-HSA-5696398 | Nucleotide Excision Repair | 5.581267e-01 | 0.253 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 5.612118e-01 | 0.251 |
R-HSA-69239 | Synthesis of DNA | 5.642755e-01 | 0.249 |
R-HSA-211000 | Gene Silencing by RNA | 5.642755e-01 | 0.249 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.673181e-01 | 0.246 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.673181e-01 | 0.246 |
R-HSA-69002 | DNA Replication Pre-Initiation | 5.703396e-01 | 0.244 |
R-HSA-5688426 | Deubiquitination | 5.720662e-01 | 0.243 |
R-HSA-1483249 | Inositol phosphate metabolism | 5.792792e-01 | 0.237 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.851362e-01 | 0.233 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.851362e-01 | 0.233 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.880344e-01 | 0.231 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.909124e-01 | 0.228 |
R-HSA-72737 | Cap-dependent Translation Initiation | 5.966090e-01 | 0.224 |
R-HSA-72613 | Eukaryotic Translation Initiation | 5.966090e-01 | 0.224 |
R-HSA-70326 | Glucose metabolism | 5.994277e-01 | 0.222 |
R-HSA-5693538 | Homology Directed Repair | 6.022268e-01 | 0.220 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.050066e-01 | 0.218 |
R-HSA-3371556 | Cellular response to heat stress | 6.105086e-01 | 0.214 |
R-HSA-446728 | Cell junction organization | 6.159161e-01 | 0.210 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.159346e-01 | 0.210 |
R-HSA-6809371 | Formation of the cornified envelope | 6.186194e-01 | 0.209 |
R-HSA-162909 | Host Interactions of HIV factors | 6.186194e-01 | 0.209 |
R-HSA-114608 | Platelet degranulation | 6.291740e-01 | 0.201 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.317671e-01 | 0.199 |
R-HSA-5673001 | RAF/MAP kinase cascade | 6.356542e-01 | 0.197 |
R-HSA-1474165 | Reproduction | 6.394391e-01 | 0.194 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.469526e-01 | 0.189 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.478014e-01 | 0.189 |
R-HSA-6798695 | Neutrophil degranulation | 6.494598e-01 | 0.187 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.567297e-01 | 0.183 |
R-HSA-9664407 | Parasite infection | 6.662385e-01 | 0.176 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.662385e-01 | 0.176 |
R-HSA-9664417 | Leishmania phagocytosis | 6.662385e-01 | 0.176 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.685746e-01 | 0.175 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.731983e-01 | 0.172 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 6.731983e-01 | 0.172 |
R-HSA-168256 | Immune System | 6.769142e-01 | 0.169 |
R-HSA-1500931 | Cell-Cell communication | 6.807589e-01 | 0.167 |
R-HSA-166520 | Signaling by NTRKs | 6.866892e-01 | 0.163 |
R-HSA-9679191 | Potential therapeutics for SARS | 6.910624e-01 | 0.160 |
R-HSA-69306 | DNA Replication | 6.975089e-01 | 0.156 |
R-HSA-73887 | Death Receptor Signaling | 6.996280e-01 | 0.155 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.017324e-01 | 0.154 |
R-HSA-1989781 | PPARA activates gene expression | 7.017324e-01 | 0.154 |
R-HSA-9610379 | HCMV Late Events | 7.058974e-01 | 0.151 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.058974e-01 | 0.151 |
R-HSA-162587 | HIV Life Cycle | 7.058974e-01 | 0.151 |
R-HSA-5633007 | Regulation of TP53 Activity | 7.120371e-01 | 0.147 |
R-HSA-109581 | Apoptosis | 7.160594e-01 | 0.145 |
R-HSA-5619102 | SLC transporter disorders | 7.258734e-01 | 0.139 |
R-HSA-5683057 | MAPK family signaling cascades | 7.268723e-01 | 0.139 |
R-HSA-5689880 | Ub-specific processing proteases | 7.390505e-01 | 0.131 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.390505e-01 | 0.131 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.390505e-01 | 0.131 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.408810e-01 | 0.130 |
R-HSA-9678108 | SARS-CoV-1 Infection | 7.426987e-01 | 0.129 |
R-HSA-3781865 | Diseases of glycosylation | 7.585000e-01 | 0.120 |
R-HSA-9679506 | SARS-CoV Infections | 7.681257e-01 | 0.115 |
R-HSA-168898 | Toll-like Receptor Cascades | 7.701216e-01 | 0.113 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.780817e-01 | 0.109 |
R-HSA-5357801 | Programmed Cell Death | 7.931914e-01 | 0.101 |
R-HSA-6805567 | Keratinization | 7.946451e-01 | 0.100 |
R-HSA-418990 | Adherens junctions interactions | 8.113192e-01 | 0.091 |
R-HSA-162906 | HIV Infection | 8.229375e-01 | 0.085 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 8.241838e-01 | 0.084 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.266505e-01 | 0.083 |
R-HSA-74160 | Gene expression (Transcription) | 8.309087e-01 | 0.080 |
R-HSA-5619115 | Disorders of transmembrane transporters | 8.462786e-01 | 0.072 |
R-HSA-421270 | Cell-cell junction organization | 8.505669e-01 | 0.070 |
R-HSA-69620 | Cell Cycle Checkpoints | 8.577882e-01 | 0.067 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 8.730210e-01 | 0.059 |
R-HSA-9824443 | Parasitic Infection Pathways | 8.791659e-01 | 0.056 |
R-HSA-9658195 | Leishmania infection | 8.791659e-01 | 0.056 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.800193e-01 | 0.056 |
R-HSA-195721 | Signaling by WNT | 8.928893e-01 | 0.049 |
R-HSA-1474244 | Extracellular matrix organization | 9.152699e-01 | 0.038 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.210869e-01 | 0.036 |
R-HSA-9694516 | SARS-CoV-2 Infection | 9.254541e-01 | 0.034 |
R-HSA-212436 | Generic Transcription Pathway | 9.292243e-01 | 0.032 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.330070e-01 | 0.030 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.419099e-01 | 0.026 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.474339e-01 | 0.023 |
R-HSA-5668914 | Diseases of metabolism | 9.575788e-01 | 0.019 |
R-HSA-72766 | Translation | 9.581815e-01 | 0.019 |
R-HSA-73857 | RNA Polymerase II Transcription | 9.605963e-01 | 0.017 |
R-HSA-168249 | Innate Immune System | 9.629047e-01 | 0.016 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.652858e-01 | 0.015 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.676874e-01 | 0.014 |
R-HSA-556833 | Metabolism of lipids | 9.829635e-01 | 0.007 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.888773e-01 | 0.005 |
R-HSA-382551 | Transport of small molecules | 9.936761e-01 | 0.003 |
R-HSA-388396 | GPCR downstream signalling | 9.965541e-01 | 0.001 |
R-HSA-372790 | Signaling by GPCR | 9.981256e-01 | 0.001 |
R-HSA-1430728 | Metabolism | 9.999987e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
BMPR1B |
0.777 | 0.494 | 1 | 0.707 |
BMPR1A |
0.774 | 0.527 | 1 | 0.704 |
ALK2 |
0.764 | 0.544 | -2 | 0.746 |
TGFBR1 |
0.762 | 0.516 | -2 | 0.769 |
DSTYK |
0.759 | 0.252 | 2 | 0.856 |
COT |
0.757 | 0.191 | 2 | 0.836 |
TGFBR2 |
0.756 | 0.339 | -2 | 0.707 |
ALK4 |
0.755 | 0.518 | -2 | 0.740 |
ACVR2A |
0.754 | 0.399 | -2 | 0.687 |
CDC7 |
0.752 | 0.120 | 1 | 0.791 |
ACVR2B |
0.751 | 0.392 | -2 | 0.682 |
MOS |
0.751 | 0.146 | 1 | 0.814 |
GRK7 |
0.750 | 0.280 | 1 | 0.653 |
GCN2 |
0.749 | 0.120 | 2 | 0.784 |
IKKB |
0.748 | 0.075 | -2 | 0.384 |
CLK3 |
0.748 | 0.154 | 1 | 0.656 |
PIM3 |
0.747 | 0.096 | -3 | 0.764 |
RAF1 |
0.746 | 0.058 | 1 | 0.767 |
CK2A2 |
0.745 | 0.312 | 1 | 0.662 |
GRK6 |
0.745 | 0.186 | 1 | 0.734 |
IKKA |
0.744 | 0.138 | -2 | 0.397 |
NEK6 |
0.744 | 0.149 | -2 | 0.530 |
GRK4 |
0.742 | 0.123 | -2 | 0.528 |
HUNK |
0.741 | 0.052 | 2 | 0.802 |
NEK7 |
0.741 | 0.127 | -3 | 0.719 |
GRK1 |
0.741 | 0.114 | -2 | 0.474 |
PLK1 |
0.740 | 0.205 | -2 | 0.548 |
BMPR2 |
0.740 | 0.220 | -2 | 0.547 |
PIM1 |
0.738 | 0.093 | -3 | 0.731 |
PLK3 |
0.738 | 0.183 | 2 | 0.740 |
CAMK2G |
0.737 | 0.047 | 2 | 0.750 |
GRK5 |
0.737 | 0.066 | -3 | 0.792 |
TBK1 |
0.737 | 0.009 | 1 | 0.677 |
PRPK |
0.736 | -0.069 | -1 | 0.697 |
ATM |
0.736 | 0.093 | 1 | 0.713 |
TLK1 |
0.736 | 0.244 | -2 | 0.627 |
CAMK1B |
0.735 | 0.001 | -3 | 0.778 |
TLK2 |
0.734 | 0.236 | 1 | 0.715 |
ULK2 |
0.734 | -0.017 | 2 | 0.757 |
MLK1 |
0.734 | 0.033 | 2 | 0.809 |
CDKL1 |
0.734 | 0.044 | -3 | 0.759 |
IKKE |
0.733 | -0.013 | 1 | 0.670 |
CK2A1 |
0.733 | 0.273 | 1 | 0.634 |
FAM20C |
0.733 | 0.066 | 2 | 0.501 |
KIS |
0.732 | 0.025 | 1 | 0.522 |
CHAK2 |
0.731 | 0.020 | -1 | 0.819 |
MTOR |
0.731 | -0.045 | 1 | 0.672 |
NDR2 |
0.731 | -0.001 | -3 | 0.730 |
ATR |
0.730 | -0.006 | 1 | 0.747 |
ANKRD3 |
0.730 | 0.068 | 1 | 0.778 |
PKN3 |
0.730 | 0.016 | -3 | 0.733 |
NUAK2 |
0.729 | -0.011 | -3 | 0.746 |
CAMK2B |
0.729 | 0.079 | 2 | 0.728 |
PDHK4 |
0.728 | -0.171 | 1 | 0.753 |
ULK1 |
0.728 | -0.007 | -3 | 0.693 |
PERK |
0.728 | 0.174 | -2 | 0.591 |
TTBK2 |
0.728 | 0.015 | 2 | 0.652 |
GRK2 |
0.728 | 0.059 | -2 | 0.484 |
RSK2 |
0.728 | 0.038 | -3 | 0.707 |
GRK3 |
0.727 | 0.090 | -2 | 0.495 |
RIPK3 |
0.727 | -0.078 | 3 | 0.567 |
LATS2 |
0.727 | 0.041 | -5 | 0.654 |
MARK4 |
0.726 | -0.040 | 4 | 0.777 |
SKMLCK |
0.726 | -0.031 | -2 | 0.411 |
DLK |
0.725 | 0.003 | 1 | 0.713 |
NIK |
0.725 | -0.057 | -3 | 0.772 |
SRPK1 |
0.725 | 0.043 | -3 | 0.731 |
TSSK2 |
0.725 | -0.023 | -5 | 0.758 |
PKCD |
0.725 | 0.012 | 2 | 0.793 |
PRKD1 |
0.724 | -0.016 | -3 | 0.693 |
NDR1 |
0.724 | -0.037 | -3 | 0.731 |
BRAF |
0.724 | 0.118 | -4 | 0.710 |
CAMLCK |
0.724 | -0.049 | -2 | 0.415 |
MST4 |
0.723 | -0.033 | 2 | 0.819 |
AMPKA1 |
0.723 | -0.037 | -3 | 0.733 |
PRKD2 |
0.723 | 0.011 | -3 | 0.660 |
AURC |
0.723 | -0.007 | -2 | 0.286 |
MAPKAPK2 |
0.723 | 0.063 | -3 | 0.653 |
CLK4 |
0.723 | 0.065 | -3 | 0.721 |
PKR |
0.723 | 0.046 | 1 | 0.767 |
PDHK1 |
0.722 | -0.155 | 1 | 0.754 |
MLK4 |
0.722 | 0.067 | 2 | 0.736 |
CDKL5 |
0.722 | 0.003 | -3 | 0.740 |
LATS1 |
0.722 | 0.081 | -3 | 0.736 |
PLK2 |
0.721 | 0.150 | -3 | 0.779 |
AURA |
0.721 | -0.007 | -2 | 0.294 |
HIPK4 |
0.720 | -0.024 | 1 | 0.651 |
SRPK2 |
0.720 | 0.061 | -3 | 0.669 |
PKACG |
0.720 | -0.030 | -2 | 0.324 |
DAPK2 |
0.720 | -0.059 | -3 | 0.766 |
MEKK3 |
0.720 | 0.030 | 1 | 0.700 |
MEK1 |
0.720 | -0.001 | 2 | 0.830 |
CK1E |
0.720 | 0.046 | -3 | 0.628 |
SRPK3 |
0.719 | 0.037 | -3 | 0.729 |
ERK5 |
0.719 | -0.068 | 1 | 0.666 |
MLK3 |
0.719 | 0.011 | 2 | 0.767 |
PKN2 |
0.719 | -0.053 | -3 | 0.739 |
MSK2 |
0.719 | 0.006 | -3 | 0.705 |
NEK9 |
0.719 | -0.088 | 2 | 0.795 |
CAMK2A |
0.719 | 0.045 | 2 | 0.769 |
CLK2 |
0.718 | 0.104 | -3 | 0.716 |
P90RSK |
0.718 | 0.000 | -3 | 0.716 |
TSSK1 |
0.718 | -0.028 | -3 | 0.737 |
P70S6KB |
0.718 | -0.013 | -3 | 0.722 |
NLK |
0.718 | -0.107 | 1 | 0.667 |
RSK4 |
0.718 | 0.048 | -3 | 0.682 |
ICK |
0.718 | -0.018 | -3 | 0.761 |
PAK1 |
0.718 | -0.029 | -2 | 0.348 |
CAMK2D |
0.718 | -0.046 | -3 | 0.712 |
AURB |
0.718 | -0.027 | -2 | 0.286 |
PRKX |
0.718 | 0.046 | -3 | 0.621 |
WNK1 |
0.717 | -0.104 | -2 | 0.402 |
RSK3 |
0.717 | -0.003 | -3 | 0.710 |
YSK4 |
0.717 | -0.025 | 1 | 0.693 |
MAPKAPK3 |
0.717 | -0.020 | -3 | 0.667 |
AMPKA2 |
0.716 | -0.040 | -3 | 0.707 |
PKACB |
0.716 | 0.008 | -2 | 0.290 |
CK1G1 |
0.716 | 0.042 | -3 | 0.657 |
MASTL |
0.716 | -0.188 | -2 | 0.413 |
HRI |
0.716 | 0.055 | -2 | 0.556 |
BCKDK |
0.716 | -0.123 | -1 | 0.619 |
NUAK1 |
0.715 | -0.024 | -3 | 0.698 |
RIPK1 |
0.715 | -0.141 | 1 | 0.750 |
MSK1 |
0.715 | 0.009 | -3 | 0.700 |
MLK2 |
0.715 | -0.104 | 2 | 0.818 |
CLK1 |
0.715 | 0.054 | -3 | 0.685 |
NIM1 |
0.715 | -0.081 | 3 | 0.620 |
PLK4 |
0.714 | 0.021 | 2 | 0.624 |
CHK1 |
0.714 | 0.012 | -3 | 0.679 |
DRAK1 |
0.714 | 0.005 | 1 | 0.660 |
QSK |
0.714 | -0.032 | 4 | 0.749 |
DNAPK |
0.714 | 0.015 | 1 | 0.674 |
IRE1 |
0.714 | -0.068 | 1 | 0.733 |
CAMK4 |
0.713 | -0.088 | -3 | 0.709 |
MEKK2 |
0.713 | 0.025 | 2 | 0.796 |
MYLK4 |
0.712 | -0.032 | -2 | 0.346 |
BRSK1 |
0.712 | -0.020 | -3 | 0.701 |
GAK |
0.712 | 0.130 | 1 | 0.791 |
WNK3 |
0.711 | -0.208 | 1 | 0.747 |
SIK |
0.711 | -0.023 | -3 | 0.678 |
PKCG |
0.710 | -0.027 | 2 | 0.760 |
MARK3 |
0.710 | -0.030 | 4 | 0.695 |
CK1D |
0.710 | 0.040 | -3 | 0.586 |
IRE2 |
0.710 | -0.043 | 2 | 0.721 |
DYRK2 |
0.710 | -0.030 | 1 | 0.547 |
NEK8 |
0.709 | 0.046 | 2 | 0.791 |
QIK |
0.709 | -0.104 | -3 | 0.711 |
DCAMKL1 |
0.709 | 0.042 | -3 | 0.684 |
PAK3 |
0.709 | -0.087 | -2 | 0.339 |
JNK3 |
0.709 | -0.005 | 1 | 0.474 |
PAK2 |
0.709 | -0.071 | -2 | 0.341 |
PRKD3 |
0.709 | -0.020 | -3 | 0.675 |
MARK2 |
0.709 | -0.039 | 4 | 0.675 |
PINK1 |
0.709 | -0.031 | 1 | 0.708 |
PKCB |
0.708 | -0.021 | 2 | 0.760 |
CAMK1G |
0.708 | -0.010 | -3 | 0.697 |
SMG1 |
0.708 | -0.050 | 1 | 0.716 |
NEK2 |
0.708 | -0.094 | 2 | 0.772 |
PKCA |
0.708 | -0.037 | 2 | 0.749 |
PASK |
0.707 | 0.039 | -3 | 0.770 |
PKCH |
0.707 | -0.038 | 2 | 0.743 |
NEK5 |
0.707 | 0.004 | 1 | 0.766 |
PHKG1 |
0.707 | -0.027 | -3 | 0.715 |
JNK2 |
0.706 | -0.012 | 1 | 0.434 |
PIM2 |
0.706 | 0.010 | -3 | 0.687 |
CDK8 |
0.706 | -0.061 | 1 | 0.481 |
MARK1 |
0.705 | -0.048 | 4 | 0.719 |
PKCZ |
0.705 | -0.056 | 2 | 0.760 |
MEKK1 |
0.705 | -0.076 | 1 | 0.727 |
SGK3 |
0.705 | -0.015 | -3 | 0.683 |
MELK |
0.705 | -0.083 | -3 | 0.686 |
ZAK |
0.705 | -0.053 | 1 | 0.688 |
MNK2 |
0.704 | -0.073 | -2 | 0.346 |
PKACA |
0.704 | -0.004 | -2 | 0.255 |
MEK5 |
0.704 | -0.126 | 2 | 0.818 |
CK1A2 |
0.703 | 0.024 | -3 | 0.592 |
BRSK2 |
0.703 | -0.078 | -3 | 0.693 |
MST2 |
0.703 | 0.050 | 1 | 0.714 |
CHAK1 |
0.703 | -0.119 | 2 | 0.750 |
PAK6 |
0.703 | -0.049 | -2 | 0.273 |
PRP4 |
0.703 | -0.010 | -3 | 0.677 |
TTBK1 |
0.703 | -0.052 | 2 | 0.578 |
DCAMKL2 |
0.703 | 0.025 | -3 | 0.701 |
VRK2 |
0.703 | -0.237 | 1 | 0.765 |
TTK |
0.703 | 0.188 | -2 | 0.596 |
AKT2 |
0.702 | -0.001 | -3 | 0.656 |
CDK1 |
0.701 | -0.026 | 1 | 0.432 |
MNK1 |
0.701 | -0.062 | -2 | 0.356 |
HIPK2 |
0.701 | -0.016 | 1 | 0.458 |
CAMK1D |
0.701 | 0.008 | -3 | 0.622 |
CAMKK1 |
0.700 | -0.071 | -2 | 0.354 |
PKG2 |
0.700 | -0.066 | -2 | 0.279 |
HIPK1 |
0.700 | -0.026 | 1 | 0.563 |
ERK1 |
0.700 | -0.045 | 1 | 0.452 |
TAK1 |
0.700 | 0.060 | 1 | 0.744 |
P38A |
0.699 | -0.064 | 1 | 0.536 |
P38G |
0.699 | -0.023 | 1 | 0.354 |
ERK2 |
0.698 | -0.054 | 1 | 0.481 |
EEF2K |
0.698 | 0.034 | 3 | 0.592 |
DAPK3 |
0.698 | -0.007 | -3 | 0.726 |
TAO3 |
0.698 | -0.037 | 1 | 0.688 |
DYRK4 |
0.698 | -0.014 | 1 | 0.460 |
WNK4 |
0.697 | -0.120 | -2 | 0.403 |
SMMLCK |
0.697 | -0.060 | -3 | 0.741 |
P38B |
0.696 | -0.047 | 1 | 0.454 |
CDK19 |
0.696 | -0.076 | 1 | 0.445 |
SNRK |
0.696 | -0.154 | 2 | 0.668 |
MAPKAPK5 |
0.696 | -0.071 | -3 | 0.661 |
PKCT |
0.696 | -0.051 | 2 | 0.748 |
CDK18 |
0.695 | -0.049 | 1 | 0.426 |
MST3 |
0.695 | -0.083 | 2 | 0.834 |
CDK5 |
0.695 | -0.049 | 1 | 0.519 |
SSTK |
0.695 | -0.069 | 4 | 0.745 |
DYRK1B |
0.695 | -0.015 | 1 | 0.479 |
DYRK3 |
0.694 | -0.022 | 1 | 0.580 |
MST1 |
0.694 | 0.023 | 1 | 0.701 |
DYRK1A |
0.694 | -0.037 | 1 | 0.567 |
P38D |
0.693 | -0.024 | 1 | 0.416 |
CAMKK2 |
0.693 | -0.094 | -2 | 0.339 |
IRAK4 |
0.693 | -0.129 | 1 | 0.752 |
NEK11 |
0.692 | -0.125 | 1 | 0.692 |
LKB1 |
0.692 | -0.081 | -3 | 0.676 |
PDK1 |
0.692 | -0.052 | 1 | 0.735 |
AKT1 |
0.691 | -0.021 | -3 | 0.649 |
DAPK1 |
0.691 | -0.020 | -3 | 0.728 |
GSK3A |
0.691 | 0.005 | 4 | 0.408 |
CDK13 |
0.691 | -0.084 | 1 | 0.473 |
MPSK1 |
0.691 | -0.055 | 1 | 0.742 |
PAK5 |
0.691 | -0.060 | -2 | 0.253 |
CDK7 |
0.691 | -0.100 | 1 | 0.500 |
JNK1 |
0.691 | -0.010 | 1 | 0.418 |
CDK2 |
0.690 | -0.082 | 1 | 0.515 |
CHK2 |
0.689 | 0.014 | -3 | 0.602 |
PDHK3_TYR |
0.689 | 0.153 | 4 | 0.858 |
GCK |
0.689 | -0.055 | 1 | 0.691 |
CDK17 |
0.688 | -0.060 | 1 | 0.362 |
MAP2K6_TYR |
0.688 | 0.174 | -1 | 0.721 |
SGK1 |
0.688 | 0.020 | -3 | 0.600 |
PHKG2 |
0.687 | -0.087 | -3 | 0.691 |
P70S6K |
0.687 | -0.046 | -3 | 0.655 |
PKCE |
0.687 | -0.027 | 2 | 0.744 |
PKCI |
0.687 | -0.071 | 2 | 0.729 |
MRCKB |
0.687 | -0.016 | -3 | 0.672 |
PDHK1_TYR |
0.687 | 0.143 | -1 | 0.740 |
PAK4 |
0.687 | -0.059 | -2 | 0.265 |
ROCK2 |
0.686 | -0.010 | -3 | 0.698 |
HIPK3 |
0.686 | -0.076 | 1 | 0.567 |
ALPHAK3 |
0.686 | 0.070 | -1 | 0.649 |
PDHK4_TYR |
0.686 | 0.140 | 2 | 0.866 |
TAO2 |
0.686 | -0.116 | 2 | 0.819 |
NEK4 |
0.686 | -0.131 | 1 | 0.726 |
CAMK1A |
0.685 | -0.013 | -3 | 0.616 |
GSK3B |
0.685 | -0.037 | 4 | 0.400 |
TNIK |
0.685 | -0.058 | 3 | 0.596 |
CDK3 |
0.685 | -0.039 | 1 | 0.387 |
MRCKA |
0.684 | -0.027 | -3 | 0.677 |
CDK12 |
0.684 | -0.082 | 1 | 0.441 |
MINK |
0.684 | -0.092 | 1 | 0.710 |
MAP2K4_TYR |
0.684 | 0.081 | -1 | 0.719 |
SLK |
0.683 | -0.057 | -2 | 0.327 |
IRAK1 |
0.683 | -0.210 | -1 | 0.635 |
MEK2 |
0.683 | -0.102 | 2 | 0.786 |
OSR1 |
0.682 | 0.029 | 2 | 0.798 |
MAP3K15 |
0.682 | -0.131 | 1 | 0.682 |
CDK14 |
0.682 | -0.076 | 1 | 0.470 |
NEK1 |
0.682 | -0.111 | 1 | 0.743 |
TXK |
0.681 | 0.151 | 1 | 0.741 |
CDK9 |
0.681 | -0.106 | 1 | 0.484 |
STK33 |
0.681 | -0.090 | 2 | 0.623 |
MAK |
0.680 | -0.005 | -2 | 0.326 |
LRRK2 |
0.680 | -0.143 | 2 | 0.795 |
CDK16 |
0.679 | -0.055 | 1 | 0.385 |
VRK1 |
0.679 | -0.151 | 2 | 0.785 |
HGK |
0.679 | -0.116 | 3 | 0.582 |
SBK |
0.679 | 0.015 | -3 | 0.554 |
DMPK1 |
0.679 | -0.009 | -3 | 0.692 |
CK1A |
0.679 | 0.015 | -3 | 0.529 |
MAP2K7_TYR |
0.679 | -0.032 | 2 | 0.831 |
MEKK6 |
0.679 | -0.175 | 1 | 0.700 |
BUB1 |
0.679 | -0.025 | -5 | 0.702 |
PKN1 |
0.679 | -0.047 | -3 | 0.653 |
PBK |
0.678 | 0.001 | 1 | 0.762 |
HPK1 |
0.678 | -0.105 | 1 | 0.678 |
BLK |
0.678 | 0.145 | -1 | 0.652 |
LOK |
0.678 | -0.119 | -2 | 0.333 |
BMPR2_TYR |
0.678 | 0.027 | -1 | 0.705 |
AKT3 |
0.678 | -0.014 | -3 | 0.606 |
HASPIN |
0.677 | 0.039 | -1 | 0.764 |
CK1G3 |
0.677 | 0.044 | -3 | 0.502 |
TESK1_TYR |
0.677 | -0.085 | 3 | 0.680 |
RIPK2 |
0.677 | -0.174 | 1 | 0.669 |
ERK7 |
0.676 | -0.061 | 2 | 0.485 |
PINK1_TYR |
0.676 | -0.040 | 1 | 0.735 |
BIKE |
0.676 | 0.063 | 1 | 0.725 |
KHS2 |
0.675 | -0.059 | 1 | 0.694 |
KHS1 |
0.674 | -0.094 | 1 | 0.698 |
CDK10 |
0.674 | -0.065 | 1 | 0.458 |
PKMYT1_TYR |
0.674 | -0.093 | 3 | 0.655 |
PKG1 |
0.674 | -0.063 | -2 | 0.253 |
ROCK1 |
0.673 | -0.030 | -3 | 0.677 |
FGR |
0.673 | 0.029 | 1 | 0.765 |
YSK1 |
0.672 | -0.129 | 2 | 0.780 |
MOK |
0.672 | -0.029 | 1 | 0.606 |
FYN |
0.672 | 0.117 | -1 | 0.597 |
ABL2 |
0.672 | 0.016 | -1 | 0.657 |
FER |
0.672 | 0.026 | 1 | 0.785 |
YES1 |
0.672 | 0.053 | -1 | 0.666 |
LCK |
0.671 | 0.070 | -1 | 0.628 |
SRMS |
0.670 | 0.058 | 1 | 0.760 |
YANK3 |
0.670 | -0.025 | 2 | 0.390 |
CRIK |
0.670 | -0.007 | -3 | 0.644 |
EPHA6 |
0.670 | -0.017 | -1 | 0.691 |
EPHA4 |
0.669 | 0.045 | 2 | 0.755 |
EPHB4 |
0.668 | -0.034 | -1 | 0.659 |
NEK3 |
0.668 | -0.155 | 1 | 0.697 |
EPHB2 |
0.667 | 0.047 | -1 | 0.633 |
RET |
0.667 | -0.109 | 1 | 0.716 |
FLT1 |
0.666 | 0.035 | -1 | 0.683 |
CK1G2 |
0.666 | 0.055 | -3 | 0.580 |
HCK |
0.666 | 0.005 | -1 | 0.627 |
ABL1 |
0.665 | -0.021 | -1 | 0.648 |
CSF1R |
0.665 | -0.049 | 3 | 0.582 |
LIMK2_TYR |
0.665 | -0.116 | -3 | 0.733 |
TNK2 |
0.664 | -0.047 | 3 | 0.539 |
FLT3 |
0.664 | -0.032 | 3 | 0.567 |
SYK |
0.664 | 0.095 | -1 | 0.600 |
CDK6 |
0.664 | -0.090 | 1 | 0.463 |
INSRR |
0.664 | -0.009 | 3 | 0.550 |
ASK1 |
0.663 | -0.128 | 1 | 0.671 |
STLK3 |
0.663 | -0.059 | 1 | 0.653 |
TEC |
0.663 | 0.035 | -1 | 0.571 |
CDK4 |
0.662 | -0.093 | 1 | 0.430 |
LIMK1_TYR |
0.662 | -0.162 | 2 | 0.803 |
MST1R |
0.662 | -0.142 | 3 | 0.601 |
KIT |
0.662 | -0.018 | 3 | 0.586 |
AAK1 |
0.662 | 0.088 | 1 | 0.642 |
EPHB3 |
0.662 | -0.020 | -1 | 0.634 |
TYK2 |
0.662 | -0.170 | 1 | 0.728 |
FRK |
0.662 | 0.019 | -1 | 0.670 |
EPHB1 |
0.661 | -0.019 | 1 | 0.751 |
ITK |
0.661 | 0.009 | -1 | 0.608 |
JAK3 |
0.661 | -0.076 | 1 | 0.699 |
MYO3A |
0.661 | -0.096 | 1 | 0.698 |
TYRO3 |
0.661 | -0.126 | 3 | 0.573 |
LYN |
0.661 | 0.035 | 3 | 0.541 |
JAK2 |
0.660 | -0.147 | 1 | 0.713 |
ERBB2 |
0.659 | -0.024 | 1 | 0.666 |
MET |
0.659 | -0.028 | 3 | 0.578 |
MYO3B |
0.659 | -0.117 | 2 | 0.789 |
ROS1 |
0.659 | -0.130 | 3 | 0.549 |
SRC |
0.659 | 0.055 | -1 | 0.609 |
EPHA5 |
0.658 | 0.029 | 2 | 0.750 |
PTK2 |
0.658 | 0.048 | -1 | 0.612 |
KDR |
0.658 | -0.072 | 3 | 0.560 |
MERTK |
0.658 | -0.044 | 3 | 0.601 |
BMX |
0.657 | -0.004 | -1 | 0.544 |
EGFR |
0.656 | 0.034 | 1 | 0.571 |
FGFR2 |
0.656 | -0.068 | 3 | 0.596 |
NEK10_TYR |
0.655 | -0.081 | 1 | 0.610 |
PTK6 |
0.654 | -0.049 | -1 | 0.556 |
EPHA7 |
0.654 | -0.024 | 2 | 0.749 |
EPHA8 |
0.654 | 0.019 | -1 | 0.626 |
TAO1 |
0.654 | -0.138 | 1 | 0.646 |
DDR1 |
0.653 | -0.183 | 4 | 0.779 |
PDGFRB |
0.652 | -0.130 | 3 | 0.581 |
FGFR4 |
0.652 | 0.014 | -1 | 0.615 |
BTK |
0.652 | -0.086 | -1 | 0.582 |
EPHA3 |
0.652 | -0.066 | 2 | 0.727 |
FGFR3 |
0.652 | -0.034 | 3 | 0.578 |
FLT4 |
0.651 | -0.061 | 3 | 0.575 |
MATK |
0.650 | -0.040 | -1 | 0.623 |
NTRK1 |
0.650 | -0.097 | -1 | 0.629 |
AXL |
0.650 | -0.131 | 3 | 0.580 |
FGFR1 |
0.650 | -0.112 | 3 | 0.575 |
PTK2B |
0.649 | -0.025 | -1 | 0.596 |
TEK |
0.649 | -0.111 | 3 | 0.530 |
TNK1 |
0.649 | -0.126 | 3 | 0.576 |
ERBB4 |
0.649 | 0.021 | 1 | 0.577 |
CSK |
0.648 | -0.054 | 2 | 0.746 |
TNNI3K_TYR |
0.645 | -0.139 | 1 | 0.722 |
NTRK3 |
0.645 | -0.075 | -1 | 0.581 |
EPHA1 |
0.644 | -0.122 | 3 | 0.557 |
JAK1 |
0.644 | -0.144 | 1 | 0.678 |
WEE1_TYR |
0.644 | -0.115 | -1 | 0.593 |
NTRK2 |
0.644 | -0.119 | 3 | 0.565 |
LTK |
0.642 | -0.140 | 3 | 0.557 |
EPHA2 |
0.642 | -0.004 | -1 | 0.594 |
PDGFRA |
0.642 | -0.211 | 3 | 0.573 |
YANK2 |
0.640 | -0.047 | 2 | 0.407 |
INSR |
0.640 | -0.112 | 3 | 0.534 |
ALK |
0.639 | -0.162 | 3 | 0.518 |
ZAP70 |
0.637 | 0.003 | -1 | 0.525 |
IGF1R |
0.635 | -0.058 | 3 | 0.503 |
FES |
0.625 | -0.081 | -1 | 0.521 |
DDR2 |
0.625 | -0.171 | 3 | 0.524 |
MUSK |
0.624 | -0.119 | 1 | 0.575 |