Motif 643 (n=105)

Position-wise Probabilities

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uniprot genes site source protein function
B5ME19 EIF3CL S181 ochoa Eukaryotic translation initiation factor 3 subunit C-like protein Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}.
F8WAN1 SPECC1L-ADORA2A S226 ochoa SPECC1L-ADORA2A readthrough (NMD candidate) None
O15061 SYNM S633 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15527 OGG1 S232 psp N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
O43290 SART1 S591 ochoa U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}.
O60264 SMARCA5 S710 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O75164 KDM4A S621 ochoa Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}.
O75410 TACC1 S248 ochoa Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.
O94782 USP1 S466 ochoa Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}.
O95071 UBR5 S1990 ochoa E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95613 PCNT S813 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95749 GGPS1 S203 ochoa Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. {ECO:0000269|PubMed:32403198}.
O95801 TTC4 S243 ochoa Tetratricopeptide repeat protein 4 (TPR repeat protein 4) May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}.
P02549 SPTA1 S1284 ochoa Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
P04350 TUBB4A S78 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P07437 TUBB S78 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DJ93 SMIM13 S58 ochoa Small integral membrane protein 13 None
P11055 MYH3 Y1376 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P11137 MAP2 S1398 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P12270 TPR S829 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P12882 MYH1 Y1379 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 S1702 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 Y1375 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 S1463 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 S1698 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 Y1377 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13533 MYH6 S1465 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13533 MYH6 S1700 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 Y1378 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P15374 UCHL3 S151 ochoa Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}.
P20393 NR1D1 S442 ochoa Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}.
P24539 ATP5PB S155 ochoa ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}.
P28370 SMARCA1 S725 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
P28715 ERCC5 S724 ochoa DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.
P35749 MYH11 S1291 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P45974 USP5 S149 ochoa Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}.
P68363 TUBA1B T80 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68371 TUBB4B S78 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q00610 CLTC S1462 ochoa Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q01196 RUNX1 S193 ochoa Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.
Q02880 TOP2B S1279 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q04721 NOTCH2 S1854 ochoa Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.
Q13523 PRP4K S23 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q13885 TUBB2A S78 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14151 SAFB2 S207 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14739 LBR S130 ochoa Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}.
Q15075 EEA1 S98 ochoa Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Q15075 EEA1 S359 ochoa Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Q15149 PLEC S3143 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q69YQ0 SPECC1L S226 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q6NSJ2 PHLDB3 S63 ochoa Pleckstrin homology-like domain family B member 3 None
Q6ZMW3 EML6 S1284 ochoa Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}.
Q70Z53 FRA10AC1 S283 ochoa Protein FRA10AC1 May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}.
Q71U36 TUBA1A T80 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7Z5K2 WAPL S130 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q7Z736 PLEKHH3 S30 ochoa Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) None
Q86SQ0 PHLDB2 S493 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86UP2 KTN1 S1310 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86V15 CASZ1 S1722 ochoa Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.
Q86V48 LUZP1 S57 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q86WN1 FCHSD1 S444 ochoa F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}.
Q86XI2 NCAPG2 S30 ochoa Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:30609410}.
Q8IWS0 PHF6 S145 ochoa PHD finger protein 6 (PHD-like zinc finger protein) Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}.
Q8IY92 SLX4 S1204 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IZD0 SAMD14 S64 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8N4S0 CCDC82 S219 ochoa Coiled-coil domain-containing protein 82 None
Q8N8J7 FAM241A S56 ochoa Uncharacterized protein FAM241A None
Q8TBZ6 TRMT10A S28 ochoa tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}.
Q8WWI1 LMO7 S751 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q96L73 NSD1 S486 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96T23 RSF1 S1310 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q99613 EIF3C S181 ochoa Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
Q9BQE3 TUBA1C T80 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BVA1 TUBB2B S78 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9BVS4 RIOK2 Y348 psp Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
Q9BXL6 CARD14 S290 ochoa Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}.
Q9H211 CDT1 S150 ochoa DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H6N6 MYH16 Y538 ochoa Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303|PubMed:15042088}.
Q9H9A6 LRRC40 S375 ochoa Leucine-rich repeat-containing protein 40 None
Q9NR30 DDX21 S171 ochoa|psp Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.
Q9NU22 MDN1 S4752 ochoa Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}.
Q9NW75 GPATCH2 S284 ochoa G patch domain-containing protein 2 Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.
Q9NZN5 ARHGEF12 S1273 ochoa Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Q9UKA4 AKAP11 S1493 ochoa A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UKE5 TNIK S996 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKX2 MYH2 Y1381 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 S1704 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX3 MYH13 Y1379 ochoa Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.
Q9UNF0 PACSIN2 S446 ochoa Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}.
Q9UQE7 SMC3 S1065 ochoa|psp Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.
Q9UQR1 ZNF148 S415 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y3T9 NOC2L S635 ochoa Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}.
Q9Y623 MYH4 Y1379 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y6D9 MAD1L1 S490 ochoa Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}.
Q9Y6J0 CABIN1 S20 ochoa Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.
Q9Y6K1 DNMT3A S393 psp DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.
R4GMW8 BIVM-ERCC5 S1178 ochoa DNA excision repair protein ERCC-5 None
P0DPH7 TUBA3C T80 Sugiyama Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PEY2 TUBA3E T80 Sugiyama Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P05787 KRT8 S274 Sugiyama Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.
P18206 VCL S1101 GPS6|SIGNOR|ELM|EPSD Vinculin (Metavinculin) (MV) Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
O15226 NKRF S532 Sugiyama NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}.
Q9BSV6 TSEN34 S93 Sugiyama tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
Q6UB35 MTHFD1L S366 Sugiyama Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.
Q9Y5S2 CDC42BPB S437 Sugiyama Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
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reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.110223e-15 14.955
R-HSA-190872 Transport of connexons to the plasma membrane 1.776357e-15 14.750
R-HSA-9646399 Aggrephagy 5.240253e-14 13.281
R-HSA-9619483 Activation of AMPK downstream of NMDARs 8.193446e-14 13.087
R-HSA-190828 Gap junction trafficking 1.549871e-13 12.810
R-HSA-389977 Post-chaperonin tubulin folding pathway 2.493561e-13 12.603
R-HSA-437239 Recycling pathway of L1 2.822187e-13 12.549
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 3.138600e-13 12.503
R-HSA-157858 Gap junction trafficking and regulation 4.132250e-13 12.384
R-HSA-190861 Gap junction assembly 5.117018e-13 12.291
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.249889e-12 11.903
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 2.904676e-12 11.537
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.777601e-12 11.238
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 7.926659e-12 11.101
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 8.907430e-12 11.050
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.586342e-11 10.800
R-HSA-68877 Mitotic Prometaphase 2.919875e-11 10.535
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.307621e-11 10.480
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.106060e-11 10.387
R-HSA-983189 Kinesins 6.897460e-11 10.161
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 9.111223e-11 10.040
R-HSA-9663891 Selective autophagy 1.137892e-10 9.944
R-HSA-373760 L1CAM interactions 1.604911e-10 9.795
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.003177e-10 9.698
R-HSA-2132295 MHC class II antigen presentation 2.892683e-10 9.539
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.899664e-10 9.538
R-HSA-6807878 COPI-mediated anterograde transport 3.161006e-10 9.500
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 3.680632e-10 9.434
R-HSA-68886 M Phase 4.443106e-10 9.352
R-HSA-2467813 Separation of Sister Chromatids 5.887943e-10 9.230
R-HSA-9833482 PKR-mediated signaling 8.098096e-10 9.092
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.127784e-09 8.948
R-HSA-68882 Mitotic Anaphase 1.319548e-09 8.880
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.392033e-09 8.856
R-HSA-438064 Post NMDA receptor activation events 1.846076e-09 8.734
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.886522e-09 8.724
R-HSA-69278 Cell Cycle, Mitotic 4.398350e-09 8.357
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.126817e-09 8.290
R-HSA-1640170 Cell Cycle 5.998286e-09 8.222
R-HSA-5620924 Intraflagellar transport 7.376336e-09 8.132
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 8.546320e-09 8.068
R-HSA-1632852 Macroautophagy 1.714912e-08 7.766
R-HSA-69275 G2/M Transition 2.464950e-08 7.608
R-HSA-199977 ER to Golgi Anterograde Transport 2.653501e-08 7.576
R-HSA-453274 Mitotic G2-G2/M phases 2.737827e-08 7.563
R-HSA-390466 Chaperonin-mediated protein folding 3.007783e-08 7.522
R-HSA-5617833 Cilium Assembly 3.037507e-08 7.517
R-HSA-9612973 Autophagy 4.518689e-08 7.345
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.025218e-08 7.395
R-HSA-391251 Protein folding 5.014337e-08 7.300
R-HSA-8856688 Golgi-to-ER retrograde transport 1.037571e-07 6.984
R-HSA-1852241 Organelle biogenesis and maintenance 1.206692e-07 6.918
R-HSA-9609690 HCMV Early Events 3.657251e-07 6.437
R-HSA-948021 Transport to the Golgi and subsequent modification 4.782152e-07 6.320
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.192036e-06 5.924
R-HSA-5610787 Hedgehog 'off' state 1.282382e-06 5.892
R-HSA-9609646 HCMV Infection 3.262834e-06 5.486
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.468533e-06 5.460
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 5.728633e-06 5.242
R-HSA-5358351 Signaling by Hedgehog 1.441127e-05 4.841
R-HSA-422475 Axon guidance 4.128391e-05 4.384
R-HSA-9675108 Nervous system development 8.093270e-05 4.092
R-HSA-913531 Interferon Signaling 1.267899e-04 3.897
R-HSA-112315 Transmission across Chemical Synapses 1.508097e-04 3.822
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.511078e-04 3.821
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.511078e-04 3.821
R-HSA-8854518 AURKA Activation by TPX2 1.828093e-04 3.738
R-HSA-9656249 Defective Base Excision Repair Associated with OGG1 2.128194e-04 3.672
R-HSA-199991 Membrane Trafficking 2.367051e-04 3.626
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 2.764263e-04 3.558
R-HSA-446203 Asparagine N-linked glycosylation 2.790159e-04 3.554
R-HSA-380287 Centrosome maturation 3.088731e-04 3.510
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 3.766297e-04 3.424
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.919293e-04 3.308
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 6.831116e-04 3.166
R-HSA-9605308 Diseases of Base Excision Repair 1.479409e-03 2.830
R-HSA-5653656 Vesicle-mediated transport 1.889597e-03 2.724
R-HSA-112316 Neuronal System 2.259002e-03 2.646
R-HSA-2262752 Cellular responses to stress 2.278251e-03 2.642
R-HSA-2470946 Cohesin Loading onto Chromatin 2.290717e-03 2.640
R-HSA-390522 Striated Muscle Contraction 2.854769e-03 2.544
R-HSA-8953897 Cellular responses to stimuli 2.918320e-03 2.535
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 3.819097e-03 2.418
R-HSA-68884 Mitotic Telophase/Cytokinesis 5.038835e-03 2.298
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.427856e-03 2.265
R-HSA-9656255 Defective OGG1 Substrate Binding 6.931309e-03 2.159
R-HSA-9657050 Defective OGG1 Localization 6.931309e-03 2.159
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 9.850567e-03 2.007
R-HSA-9700206 Signaling by ALK in cancer 9.850567e-03 2.007
R-HSA-1912422 Pre-NOTCH Expression and Processing 1.162141e-02 1.935
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.338009e-02 1.874
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 1.367614e-02 1.864
R-HSA-9656256 Defective OGG1 Substrate Processing 1.381500e-02 1.860
R-HSA-73894 DNA Repair 1.724817e-02 1.763
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.871002e-02 1.728
R-HSA-400685 Sema4D in semaphorin signaling 2.002684e-02 1.698
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 2.124440e-02 1.673
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.124440e-02 1.673
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 2.249204e-02 1.648
R-HSA-191273 Cholesterol biosynthesis 2.256365e-02 1.647
R-HSA-597592 Post-translational protein modification 2.288258e-02 1.640
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 2.324480e-02 1.634
R-HSA-397014 Muscle contraction 2.347107e-02 1.629
R-HSA-109582 Hemostasis 2.479330e-02 1.606
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2.641082e-02 1.578
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 3.350111e-02 1.475
R-HSA-432720 Lysosome Vesicle Biogenesis 3.652262e-02 1.437
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 2.916531e-02 1.535
R-HSA-69205 G1/S-Specific Transcription 3.652262e-02 1.437
R-HSA-1280218 Adaptive Immune System 3.451616e-02 1.462
R-HSA-9824446 Viral Infection Pathways 2.846690e-02 1.546
R-HSA-73927 Depurination 3.964494e-02 1.402
R-HSA-8878159 Transcriptional regulation by RUNX3 4.010011e-02 1.397
R-HSA-5083630 Defective LFNG causes SCDO3 4.088005e-02 1.388
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 4.088005e-02 1.388
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 4.753047e-02 1.323
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 4.753047e-02 1.323
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 4.787033e-02 1.320
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 5.186949e-02 1.285
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 5.307737e-02 1.275
R-HSA-774815 Nucleosome assembly 5.307737e-02 1.275
R-HSA-6783310 Fanconi Anemia Pathway 5.307737e-02 1.275
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 5.413519e-02 1.267
R-HSA-9675135 Diseases of DNA repair 5.485605e-02 1.261
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 6.069452e-02 1.217
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 6.720877e-02 1.173
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 7.367823e-02 1.133
R-HSA-446107 Type I hemidesmosome assembly 7.367823e-02 1.133
R-HSA-196025 Formation of annular gap junctions 7.367823e-02 1.133
R-HSA-190873 Gap junction degradation 8.010323e-02 1.096
R-HSA-9700645 ALK mutants bind TKIs 8.010323e-02 1.096
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 9.911441e-02 1.004
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 6.787074e-02 1.168
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 6.720877e-02 1.173
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocy... 7.367823e-02 1.133
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 8.648406e-02 1.063
R-HSA-9707616 Heme signaling 8.591167e-02 1.066
R-HSA-6784531 tRNA processing in the nucleus 8.591167e-02 1.066
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 7.974766e-02 1.098
R-HSA-445355 Smooth Muscle Contraction 6.787074e-02 1.168
R-HSA-5693606 DNA Double Strand Break Response 9.648961e-02 1.016
R-HSA-110357 Displacement of DNA glycosylase by APEX1 6.720877e-02 1.173
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 8.010323e-02 1.096
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 8.010323e-02 1.096
R-HSA-73929 Base-Excision Repair, AP Site Formation 6.980627e-02 1.156
R-HSA-373755 Semaphorin interactions 8.799762e-02 1.056
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 1.052044e-01 0.978
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.053645e-01 0.977
R-HSA-8866427 VLDLR internalisation and degradation 1.053645e-01 0.977
R-HSA-8951936 RUNX3 regulates p14-ARF 1.053645e-01 0.977
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.074158e-01 0.969
R-HSA-157118 Signaling by NOTCH 1.084795e-01 0.965
R-HSA-69242 S Phase 1.098879e-01 0.959
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1.115717e-01 0.952
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.115717e-01 0.952
R-HSA-8852135 Protein ubiquitination 1.141237e-01 0.943
R-HSA-5693532 DNA Double-Strand Break Repair 1.172734e-01 0.931
R-HSA-177504 Retrograde neurotrophin signalling 1.177361e-01 0.929
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 1.299381e-01 0.886
R-HSA-1912420 Pre-NOTCH Processing in Golgi 1.538426e-01 0.813
R-HSA-163210 Formation of ATP by chemiosmotic coupling 1.597163e-01 0.797
R-HSA-9615710 Late endosomal microautophagy 2.162756e-01 0.665
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.217196e-01 0.654
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.271262e-01 0.644
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.271262e-01 0.644
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 2.378278e-01 0.624
R-HSA-1855170 IPs transport between nucleus and cytosol 2.378278e-01 0.624
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.378278e-01 0.624
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.431235e-01 0.614
R-HSA-5696400 Dual Incision in GG-NER 2.483826e-01 0.605
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.536056e-01 0.596
R-HSA-1980145 Signaling by NOTCH2 2.483826e-01 0.605
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 1.655496e-01 0.781
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.359763e-01 0.867
R-HSA-350054 Notch-HLH transcription pathway 1.770961e-01 0.752
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.884842e-01 0.725
R-HSA-445095 Interaction between L1 and Ankyrins 2.052741e-01 0.688
R-HSA-8949613 Cristae formation 2.052741e-01 0.688
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.162756e-01 0.665
R-HSA-9613829 Chaperone Mediated Autophagy 1.479283e-01 0.830
R-HSA-5099900 WNT5A-dependent internalization of FZD4 1.299381e-01 0.886
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.431235e-01 0.614
R-HSA-68962 Activation of the pre-replicative complex 2.217196e-01 0.654
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.713428e-01 0.766
R-HSA-5334118 DNA methylation 2.162756e-01 0.665
R-HSA-180746 Nuclear import of Rev protein 2.483826e-01 0.605
R-HSA-68875 Mitotic Prophase 2.391386e-01 0.621
R-HSA-3928663 EPHA-mediated growth cone collapse 2.052741e-01 0.688
R-HSA-3214842 HDMs demethylate histones 1.941195e-01 0.712
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.378278e-01 0.624
R-HSA-5693537 Resolution of D-Loop Structures 2.431235e-01 0.614
R-HSA-8964038 LDL clearance 1.770961e-01 0.752
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.655496e-01 0.781
R-HSA-6807062 Cholesterol biosynthesis via lathosterol 1.770961e-01 0.752
R-HSA-9022692 Regulation of MECP2 expression and activity 2.378278e-01 0.624
R-HSA-392499 Metabolism of proteins 2.412427e-01 0.618
R-HSA-73884 Base Excision Repair 1.515065e-01 0.820
R-HSA-9945266 Differentiation of T cells 1.299381e-01 0.886
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 1.299381e-01 0.886
R-HSA-1592230 Mitochondrial biogenesis 2.314589e-01 0.636
R-HSA-72306 tRNA processing 1.453030e-01 0.838
R-HSA-2559580 Oxidative Stress Induced Senescence 1.858908e-01 0.731
R-HSA-1266738 Developmental Biology 1.367504e-01 0.864
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 2.483826e-01 0.605
R-HSA-2559583 Cellular Senescence 1.617446e-01 0.791
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 2.536056e-01 0.596
R-HSA-162582 Signal Transduction 2.107770e-01 0.676
R-HSA-2682334 EPH-Ephrin signaling 1.587662e-01 0.799
R-HSA-8957322 Metabolism of steroids 2.183461e-01 0.661
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.324955e-01 0.634
R-HSA-73886 Chromosome Maintenance 2.417016e-01 0.617
R-HSA-5663205 Infectious disease 2.088703e-01 0.680
R-HSA-1280215 Cytokine Signaling in Immune system 1.403338e-01 0.853
R-HSA-69206 G1/S Transition 2.545340e-01 0.594
R-HSA-212300 PRC2 methylates histones and DNA 2.587925e-01 0.587
R-HSA-3247509 Chromatin modifying enzymes 2.599567e-01 0.585
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 2.639438e-01 0.578
R-HSA-180910 Vpr-mediated nuclear import of PICs 2.639438e-01 0.578
R-HSA-110331 Cleavage of the damaged purine 2.639438e-01 0.578
R-HSA-549127 SLC-mediated transport of organic cations 2.639438e-01 0.578
R-HSA-196757 Metabolism of folate and pterines 2.639438e-01 0.578
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.690596e-01 0.570
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 2.741401e-01 0.562
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 2.741401e-01 0.562
R-HSA-168276 NS1 Mediated Effects on Host Pathways 2.741401e-01 0.562
R-HSA-8964043 Plasma lipoprotein clearance 2.741401e-01 0.562
R-HSA-9909396 Circadian clock 2.750929e-01 0.561
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.791856e-01 0.554
R-HSA-177243 Interactions of Rev with host cellular proteins 2.791856e-01 0.554
R-HSA-176033 Interactions of Vpr with host cellular proteins 2.791856e-01 0.554
R-HSA-5696395 Formation of Incision Complex in GG-NER 2.791856e-01 0.554
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.841964e-01 0.546
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 2.841964e-01 0.546
R-HSA-3214841 PKMTs methylate histone lysines 2.841964e-01 0.546
R-HSA-73933 Resolution of Abasic Sites (AP sites) 2.841964e-01 0.546
R-HSA-9018519 Estrogen-dependent gene expression 2.879348e-01 0.541
R-HSA-4839726 Chromatin organization 2.881441e-01 0.540
R-HSA-5674135 MAP2K and MAPK activation 2.891726e-01 0.539
R-HSA-9656223 Signaling by RAF1 mutants 2.891726e-01 0.539
R-HSA-110329 Cleavage of the damaged pyrimidine 2.941146e-01 0.531
R-HSA-73928 Depyrimidination 2.941146e-01 0.531
R-HSA-9710421 Defective pyroptosis 2.990224e-01 0.524
R-HSA-3214858 RMTs methylate histone arginines 3.038965e-01 0.517
R-HSA-8856828 Clathrin-mediated endocytosis 3.084283e-01 0.511
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.087370e-01 0.510
R-HSA-2299718 Condensation of Prophase Chromosomes 3.135441e-01 0.504
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.135441e-01 0.504
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.135441e-01 0.504
R-HSA-9649948 Signaling downstream of RAS mutants 3.135441e-01 0.504
R-HSA-6802949 Signaling by RAS mutants 3.135441e-01 0.504
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.135441e-01 0.504
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.135441e-01 0.504
R-HSA-75153 Apoptotic execution phase 3.135441e-01 0.504
R-HSA-9734767 Developmental Cell Lineages 3.146683e-01 0.502
R-HSA-453279 Mitotic G1 phase and G1/S transition 3.160871e-01 0.500
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.183181e-01 0.497
R-HSA-73893 DNA Damage Bypass 3.277676e-01 0.484
R-HSA-68949 Orc1 removal from chromatin 3.416990e-01 0.466
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.416990e-01 0.466
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 3.450561e-01 0.462
R-HSA-1221632 Meiotic synapsis 3.462788e-01 0.461
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.462788e-01 0.461
R-HSA-72649 Translation initiation complex formation 3.508272e-01 0.455
R-HSA-72702 Ribosomal scanning and start codon recognition 3.598299e-01 0.444
R-HSA-193648 NRAGE signals death through JNK 3.598299e-01 0.444
R-HSA-2980766 Nuclear Envelope Breakdown 3.642848e-01 0.439
R-HSA-9764561 Regulation of CDH1 Function 3.642848e-01 0.439
R-HSA-6782135 Dual incision in TC-NER 3.687089e-01 0.433
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 3.687089e-01 0.433
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 3.687089e-01 0.433
R-HSA-191859 snRNP Assembly 3.731025e-01 0.428
R-HSA-194441 Metabolism of non-coding RNA 3.731025e-01 0.428
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 3.731025e-01 0.428
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 3.774658e-01 0.423
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 3.789728e-01 0.421
R-HSA-168325 Viral Messenger RNA Synthesis 3.817990e-01 0.418
R-HSA-8953854 Metabolism of RNA 3.860103e-01 0.413
R-HSA-375165 NCAM signaling for neurite out-growth 3.861024e-01 0.413
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.861024e-01 0.413
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 3.861024e-01 0.413
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 3.988350e-01 0.399
R-HSA-168255 Influenza Infection 4.010573e-01 0.397
R-HSA-6782315 tRNA modification in the nucleus and cytosol 4.030208e-01 0.395
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.071776e-01 0.390
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 4.113058e-01 0.386
R-HSA-8868773 rRNA processing in the nucleus and cytosol 4.227744e-01 0.374
R-HSA-427413 NoRC negatively regulates rRNA expression 4.235203e-01 0.373
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.235203e-01 0.373
R-HSA-1643685 Disease 4.259569e-01 0.371
R-HSA-5578749 Transcriptional regulation by small RNAs 4.275356e-01 0.369
R-HSA-212165 Epigenetic regulation of gene expression 4.276196e-01 0.369
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 4.315233e-01 0.365
R-HSA-69052 Switching of origins to a post-replicative state 4.315233e-01 0.365
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.315233e-01 0.365
R-HSA-9013694 Signaling by NOTCH4 4.354834e-01 0.361
R-HSA-72163 mRNA Splicing - Major Pathway 4.370301e-01 0.359
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 4.394162e-01 0.357
R-HSA-1169408 ISG15 antiviral mechanism 4.394162e-01 0.357
R-HSA-5689603 UCH proteinases 4.433219e-01 0.353
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 4.472006e-01 0.349
R-HSA-383280 Nuclear Receptor transcription pathway 4.510524e-01 0.346
R-HSA-416482 G alpha (12/13) signalling events 4.510524e-01 0.346
R-HSA-4086400 PCP/CE pathway 4.510524e-01 0.346
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 4.586766e-01 0.338
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 4.586766e-01 0.338
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 4.624492e-01 0.335
R-HSA-72172 mRNA Splicing 4.626678e-01 0.335
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 4.661958e-01 0.331
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.736114e-01 0.325
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 4.736114e-01 0.325
R-HSA-6802957 Oncogenic MAPK signaling 4.772809e-01 0.321
R-HSA-1500620 Meiosis 4.772809e-01 0.321
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 4.809250e-01 0.318
R-HSA-141424 Amplification of signal from the kinetochores 4.809250e-01 0.318
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 4.845439e-01 0.315
R-HSA-9645723 Diseases of programmed cell death 4.917069e-01 0.308
R-HSA-9006931 Signaling by Nuclear Receptors 4.994547e-01 0.302
R-HSA-8951664 Neddylation 5.009288e-01 0.300
R-HSA-8986944 Transcriptional Regulation by MECP2 5.022668e-01 0.299
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 5.091857e-01 0.293
R-HSA-8878171 Transcriptional regulation by RUNX1 5.118505e-01 0.291
R-HSA-68867 Assembly of the pre-replicative complex 5.126093e-01 0.290
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.142349e-01 0.289
R-HSA-1474290 Collagen formation 5.160092e-01 0.287
R-HSA-72689 Formation of a pool of free 40S subunits 5.227387e-01 0.282
R-HSA-72312 rRNA processing 5.247508e-01 0.280
R-HSA-8957275 Post-translational protein phosphorylation 5.326595e-01 0.274
R-HSA-8939211 ESR-mediated signaling 5.353270e-01 0.271
R-HSA-193704 p75 NTR receptor-mediated signalling 5.359207e-01 0.271
R-HSA-69618 Mitotic Spindle Checkpoint 5.391595e-01 0.268
R-HSA-70171 Glycolysis 5.391595e-01 0.268
R-HSA-9842860 Regulation of endogenous retroelements 5.455699e-01 0.263
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5.455699e-01 0.263
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.518919e-01 0.258
R-HSA-9860931 Response of endothelial cells to shear stress 5.518919e-01 0.258
R-HSA-5696398 Nucleotide Excision Repair 5.581267e-01 0.253
R-HSA-9692914 SARS-CoV-1-host interactions 5.612118e-01 0.251
R-HSA-69239 Synthesis of DNA 5.642755e-01 0.249
R-HSA-211000 Gene Silencing by RNA 5.642755e-01 0.249
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.673181e-01 0.246
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.673181e-01 0.246
R-HSA-69002 DNA Replication Pre-Initiation 5.703396e-01 0.244
R-HSA-5688426 Deubiquitination 5.720662e-01 0.243
R-HSA-1483249 Inositol phosphate metabolism 5.792792e-01 0.237
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.851362e-01 0.233
R-HSA-9855142 Cellular responses to mechanical stimuli 5.851362e-01 0.233
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 5.880344e-01 0.231
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 5.909124e-01 0.228
R-HSA-72737 Cap-dependent Translation Initiation 5.966090e-01 0.224
R-HSA-72613 Eukaryotic Translation Initiation 5.966090e-01 0.224
R-HSA-70326 Glucose metabolism 5.994277e-01 0.222
R-HSA-5693538 Homology Directed Repair 6.022268e-01 0.220
R-HSA-8878166 Transcriptional regulation by RUNX2 6.050066e-01 0.218
R-HSA-3371556 Cellular response to heat stress 6.105086e-01 0.214
R-HSA-446728 Cell junction organization 6.159161e-01 0.210
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.159346e-01 0.210
R-HSA-6809371 Formation of the cornified envelope 6.186194e-01 0.209
R-HSA-162909 Host Interactions of HIV factors 6.186194e-01 0.209
R-HSA-114608 Platelet degranulation 6.291740e-01 0.201
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.317671e-01 0.199
R-HSA-5673001 RAF/MAP kinase cascade 6.356542e-01 0.197
R-HSA-1474165 Reproduction 6.394391e-01 0.194
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.469526e-01 0.189
R-HSA-5684996 MAPK1/MAPK3 signaling 6.478014e-01 0.189
R-HSA-6798695 Neutrophil degranulation 6.494598e-01 0.187
R-HSA-3858494 Beta-catenin independent WNT signaling 6.567297e-01 0.183
R-HSA-9664407 Parasite infection 6.662385e-01 0.176
R-HSA-9664422 FCGR3A-mediated phagocytosis 6.662385e-01 0.176
R-HSA-9664417 Leishmania phagocytosis 6.662385e-01 0.176
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 6.685746e-01 0.175
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.731983e-01 0.172
R-HSA-162599 Late Phase of HIV Life Cycle 6.731983e-01 0.172
R-HSA-168256 Immune System 6.769142e-01 0.169
R-HSA-1500931 Cell-Cell communication 6.807589e-01 0.167
R-HSA-166520 Signaling by NTRKs 6.866892e-01 0.163
R-HSA-9679191 Potential therapeutics for SARS 6.910624e-01 0.160
R-HSA-69306 DNA Replication 6.975089e-01 0.156
R-HSA-73887 Death Receptor Signaling 6.996280e-01 0.155
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.017324e-01 0.154
R-HSA-1989781 PPARA activates gene expression 7.017324e-01 0.154
R-HSA-9610379 HCMV Late Events 7.058974e-01 0.151
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.058974e-01 0.151
R-HSA-162587 HIV Life Cycle 7.058974e-01 0.151
R-HSA-5633007 Regulation of TP53 Activity 7.120371e-01 0.147
R-HSA-109581 Apoptosis 7.160594e-01 0.145
R-HSA-5619102 SLC transporter disorders 7.258734e-01 0.139
R-HSA-5683057 MAPK family signaling cascades 7.268723e-01 0.139
R-HSA-5689880 Ub-specific processing proteases 7.390505e-01 0.131
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.390505e-01 0.131
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.390505e-01 0.131
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.408810e-01 0.130
R-HSA-9678108 SARS-CoV-1 Infection 7.426987e-01 0.129
R-HSA-3781865 Diseases of glycosylation 7.585000e-01 0.120
R-HSA-9679506 SARS-CoV Infections 7.681257e-01 0.115
R-HSA-168898 Toll-like Receptor Cascades 7.701216e-01 0.113
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.780817e-01 0.109
R-HSA-5357801 Programmed Cell Death 7.931914e-01 0.101
R-HSA-6805567 Keratinization 7.946451e-01 0.100
R-HSA-418990 Adherens junctions interactions 8.113192e-01 0.091
R-HSA-162906 HIV Infection 8.229375e-01 0.085
R-HSA-9705683 SARS-CoV-2-host interactions 8.241838e-01 0.084
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.266505e-01 0.083
R-HSA-74160 Gene expression (Transcription) 8.309087e-01 0.080
R-HSA-5619115 Disorders of transmembrane transporters 8.462786e-01 0.072
R-HSA-421270 Cell-cell junction organization 8.505669e-01 0.070
R-HSA-69620 Cell Cycle Checkpoints 8.577882e-01 0.067
R-HSA-76002 Platelet activation, signaling and aggregation 8.730210e-01 0.059
R-HSA-9824443 Parasitic Infection Pathways 8.791659e-01 0.056
R-HSA-9658195 Leishmania infection 8.791659e-01 0.056
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.800193e-01 0.056
R-HSA-195721 Signaling by WNT 8.928893e-01 0.049
R-HSA-1474244 Extracellular matrix organization 9.152699e-01 0.038
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.210869e-01 0.036
R-HSA-9694516 SARS-CoV-2 Infection 9.254541e-01 0.034
R-HSA-212436 Generic Transcription Pathway 9.292243e-01 0.032
R-HSA-196854 Metabolism of vitamins and cofactors 9.330070e-01 0.030
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.419099e-01 0.026
R-HSA-425407 SLC-mediated transmembrane transport 9.474339e-01 0.023
R-HSA-5668914 Diseases of metabolism 9.575788e-01 0.019
R-HSA-72766 Translation 9.581815e-01 0.019
R-HSA-73857 RNA Polymerase II Transcription 9.605963e-01 0.017
R-HSA-168249 Innate Immune System 9.629047e-01 0.016
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.652858e-01 0.015
R-HSA-3700989 Transcriptional Regulation by TP53 9.676874e-01 0.014
R-HSA-556833 Metabolism of lipids 9.829635e-01 0.007
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 9.888773e-01 0.005
R-HSA-382551 Transport of small molecules 9.936761e-01 0.003
R-HSA-388396 GPCR downstream signalling 9.965541e-01 0.001
R-HSA-372790 Signaling by GPCR 9.981256e-01 0.001
R-HSA-1430728 Metabolism 9.999987e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
BMPR1BBMPR1B 0.777 0.494 1 0.707
BMPR1ABMPR1A 0.774 0.527 1 0.704
ALK2ALK2 0.764 0.544 -2 0.746
TGFBR1TGFBR1 0.762 0.516 -2 0.769
DSTYKDSTYK 0.759 0.252 2 0.856
COTCOT 0.757 0.191 2 0.836
TGFBR2TGFBR2 0.756 0.339 -2 0.707
ALK4ALK4 0.755 0.518 -2 0.740
ACVR2AACVR2A 0.754 0.399 -2 0.687
CDC7CDC7 0.752 0.120 1 0.791
ACVR2BACVR2B 0.751 0.392 -2 0.682
MOSMOS 0.751 0.146 1 0.814
GRK7GRK7 0.750 0.280 1 0.653
GCN2GCN2 0.749 0.120 2 0.784
IKKBIKKB 0.748 0.075 -2 0.384
CLK3CLK3 0.748 0.154 1 0.656
PIM3PIM3 0.747 0.096 -3 0.764
RAF1RAF1 0.746 0.058 1 0.767
CK2A2CK2A2 0.745 0.312 1 0.662
GRK6GRK6 0.745 0.186 1 0.734
IKKAIKKA 0.744 0.138 -2 0.397
NEK6NEK6 0.744 0.149 -2 0.530
GRK4GRK4 0.742 0.123 -2 0.528
HUNKHUNK 0.741 0.052 2 0.802
NEK7NEK7 0.741 0.127 -3 0.719
GRK1GRK1 0.741 0.114 -2 0.474
PLK1PLK1 0.740 0.205 -2 0.548
BMPR2BMPR2 0.740 0.220 -2 0.547
PIM1PIM1 0.738 0.093 -3 0.731
PLK3PLK3 0.738 0.183 2 0.740
CAMK2GCAMK2G 0.737 0.047 2 0.750
GRK5GRK5 0.737 0.066 -3 0.792
TBK1TBK1 0.737 0.009 1 0.677
PRPKPRPK 0.736 -0.069 -1 0.697
ATMATM 0.736 0.093 1 0.713
TLK1TLK1 0.736 0.244 -2 0.627
CAMK1BCAMK1B 0.735 0.001 -3 0.778
TLK2TLK2 0.734 0.236 1 0.715
ULK2ULK2 0.734 -0.017 2 0.757
MLK1MLK1 0.734 0.033 2 0.809
CDKL1CDKL1 0.734 0.044 -3 0.759
IKKEIKKE 0.733 -0.013 1 0.670
CK2A1CK2A1 0.733 0.273 1 0.634
FAM20CFAM20C 0.733 0.066 2 0.501
KISKIS 0.732 0.025 1 0.522
CHAK2CHAK2 0.731 0.020 -1 0.819
MTORMTOR 0.731 -0.045 1 0.672
NDR2NDR2 0.731 -0.001 -3 0.730
ATRATR 0.730 -0.006 1 0.747
ANKRD3ANKRD3 0.730 0.068 1 0.778
PKN3PKN3 0.730 0.016 -3 0.733
NUAK2NUAK2 0.729 -0.011 -3 0.746
CAMK2BCAMK2B 0.729 0.079 2 0.728
PDHK4PDHK4 0.728 -0.171 1 0.753
ULK1ULK1 0.728 -0.007 -3 0.693
PERKPERK 0.728 0.174 -2 0.591
TTBK2TTBK2 0.728 0.015 2 0.652
GRK2GRK2 0.728 0.059 -2 0.484
RSK2RSK2 0.728 0.038 -3 0.707
GRK3GRK3 0.727 0.090 -2 0.495
RIPK3RIPK3 0.727 -0.078 3 0.567
LATS2LATS2 0.727 0.041 -5 0.654
MARK4MARK4 0.726 -0.040 4 0.777
SKMLCKSKMLCK 0.726 -0.031 -2 0.411
DLKDLK 0.725 0.003 1 0.713
NIKNIK 0.725 -0.057 -3 0.772
SRPK1SRPK1 0.725 0.043 -3 0.731
TSSK2TSSK2 0.725 -0.023 -5 0.758
PKCDPKCD 0.725 0.012 2 0.793
PRKD1PRKD1 0.724 -0.016 -3 0.693
NDR1NDR1 0.724 -0.037 -3 0.731
BRAFBRAF 0.724 0.118 -4 0.710
CAMLCKCAMLCK 0.724 -0.049 -2 0.415
MST4MST4 0.723 -0.033 2 0.819
AMPKA1AMPKA1 0.723 -0.037 -3 0.733
PRKD2PRKD2 0.723 0.011 -3 0.660
AURCAURC 0.723 -0.007 -2 0.286
MAPKAPK2MAPKAPK2 0.723 0.063 -3 0.653
CLK4CLK4 0.723 0.065 -3 0.721
PKRPKR 0.723 0.046 1 0.767
PDHK1PDHK1 0.722 -0.155 1 0.754
MLK4MLK4 0.722 0.067 2 0.736
CDKL5CDKL5 0.722 0.003 -3 0.740
LATS1LATS1 0.722 0.081 -3 0.736
PLK2PLK2 0.721 0.150 -3 0.779
AURAAURA 0.721 -0.007 -2 0.294
HIPK4HIPK4 0.720 -0.024 1 0.651
SRPK2SRPK2 0.720 0.061 -3 0.669
PKACGPKACG 0.720 -0.030 -2 0.324
DAPK2DAPK2 0.720 -0.059 -3 0.766
MEKK3MEKK3 0.720 0.030 1 0.700
MEK1MEK1 0.720 -0.001 2 0.830
CK1ECK1E 0.720 0.046 -3 0.628
SRPK3SRPK3 0.719 0.037 -3 0.729
ERK5ERK5 0.719 -0.068 1 0.666
MLK3MLK3 0.719 0.011 2 0.767
PKN2PKN2 0.719 -0.053 -3 0.739
MSK2MSK2 0.719 0.006 -3 0.705
NEK9NEK9 0.719 -0.088 2 0.795
CAMK2ACAMK2A 0.719 0.045 2 0.769
CLK2CLK2 0.718 0.104 -3 0.716
P90RSKP90RSK 0.718 0.000 -3 0.716
TSSK1TSSK1 0.718 -0.028 -3 0.737
P70S6KBP70S6KB 0.718 -0.013 -3 0.722
NLKNLK 0.718 -0.107 1 0.667
RSK4RSK4 0.718 0.048 -3 0.682
ICKICK 0.718 -0.018 -3 0.761
PAK1PAK1 0.718 -0.029 -2 0.348
CAMK2DCAMK2D 0.718 -0.046 -3 0.712
AURBAURB 0.718 -0.027 -2 0.286
PRKXPRKX 0.718 0.046 -3 0.621
WNK1WNK1 0.717 -0.104 -2 0.402
RSK3RSK3 0.717 -0.003 -3 0.710
YSK4YSK4 0.717 -0.025 1 0.693
MAPKAPK3MAPKAPK3 0.717 -0.020 -3 0.667
AMPKA2AMPKA2 0.716 -0.040 -3 0.707
PKACBPKACB 0.716 0.008 -2 0.290
CK1G1CK1G1 0.716 0.042 -3 0.657
MASTLMASTL 0.716 -0.188 -2 0.413
HRIHRI 0.716 0.055 -2 0.556
BCKDKBCKDK 0.716 -0.123 -1 0.619
NUAK1NUAK1 0.715 -0.024 -3 0.698
RIPK1RIPK1 0.715 -0.141 1 0.750
MSK1MSK1 0.715 0.009 -3 0.700
MLK2MLK2 0.715 -0.104 2 0.818
CLK1CLK1 0.715 0.054 -3 0.685
NIM1NIM1 0.715 -0.081 3 0.620
PLK4PLK4 0.714 0.021 2 0.624
CHK1CHK1 0.714 0.012 -3 0.679
DRAK1DRAK1 0.714 0.005 1 0.660
QSKQSK 0.714 -0.032 4 0.749
DNAPKDNAPK 0.714 0.015 1 0.674
IRE1IRE1 0.714 -0.068 1 0.733
CAMK4CAMK4 0.713 -0.088 -3 0.709
MEKK2MEKK2 0.713 0.025 2 0.796
MYLK4MYLK4 0.712 -0.032 -2 0.346
BRSK1BRSK1 0.712 -0.020 -3 0.701
GAKGAK 0.712 0.130 1 0.791
WNK3WNK3 0.711 -0.208 1 0.747
SIKSIK 0.711 -0.023 -3 0.678
PKCGPKCG 0.710 -0.027 2 0.760
MARK3MARK3 0.710 -0.030 4 0.695
CK1DCK1D 0.710 0.040 -3 0.586
IRE2IRE2 0.710 -0.043 2 0.721
DYRK2DYRK2 0.710 -0.030 1 0.547
NEK8NEK8 0.709 0.046 2 0.791
QIKQIK 0.709 -0.104 -3 0.711
DCAMKL1DCAMKL1 0.709 0.042 -3 0.684
PAK3PAK3 0.709 -0.087 -2 0.339
JNK3JNK3 0.709 -0.005 1 0.474
PAK2PAK2 0.709 -0.071 -2 0.341
PRKD3PRKD3 0.709 -0.020 -3 0.675
MARK2MARK2 0.709 -0.039 4 0.675
PINK1PINK1 0.709 -0.031 1 0.708
PKCBPKCB 0.708 -0.021 2 0.760
CAMK1GCAMK1G 0.708 -0.010 -3 0.697
SMG1SMG1 0.708 -0.050 1 0.716
NEK2NEK2 0.708 -0.094 2 0.772
PKCAPKCA 0.708 -0.037 2 0.749
PASKPASK 0.707 0.039 -3 0.770
PKCHPKCH 0.707 -0.038 2 0.743
NEK5NEK5 0.707 0.004 1 0.766
PHKG1PHKG1 0.707 -0.027 -3 0.715
JNK2JNK2 0.706 -0.012 1 0.434
PIM2PIM2 0.706 0.010 -3 0.687
CDK8CDK8 0.706 -0.061 1 0.481
MARK1MARK1 0.705 -0.048 4 0.719
PKCZPKCZ 0.705 -0.056 2 0.760
MEKK1MEKK1 0.705 -0.076 1 0.727
SGK3SGK3 0.705 -0.015 -3 0.683
MELKMELK 0.705 -0.083 -3 0.686
ZAKZAK 0.705 -0.053 1 0.688
MNK2MNK2 0.704 -0.073 -2 0.346
PKACAPKACA 0.704 -0.004 -2 0.255
MEK5MEK5 0.704 -0.126 2 0.818
CK1A2CK1A2 0.703 0.024 -3 0.592
BRSK2BRSK2 0.703 -0.078 -3 0.693
MST2MST2 0.703 0.050 1 0.714
CHAK1CHAK1 0.703 -0.119 2 0.750
PAK6PAK6 0.703 -0.049 -2 0.273
PRP4PRP4 0.703 -0.010 -3 0.677
TTBK1TTBK1 0.703 -0.052 2 0.578
DCAMKL2DCAMKL2 0.703 0.025 -3 0.701
VRK2VRK2 0.703 -0.237 1 0.765
TTKTTK 0.703 0.188 -2 0.596
AKT2AKT2 0.702 -0.001 -3 0.656
CDK1CDK1 0.701 -0.026 1 0.432
MNK1MNK1 0.701 -0.062 -2 0.356
HIPK2HIPK2 0.701 -0.016 1 0.458
CAMK1DCAMK1D 0.701 0.008 -3 0.622
CAMKK1CAMKK1 0.700 -0.071 -2 0.354
PKG2PKG2 0.700 -0.066 -2 0.279
HIPK1HIPK1 0.700 -0.026 1 0.563
ERK1ERK1 0.700 -0.045 1 0.452
TAK1TAK1 0.700 0.060 1 0.744
P38AP38A 0.699 -0.064 1 0.536
P38GP38G 0.699 -0.023 1 0.354
ERK2ERK2 0.698 -0.054 1 0.481
EEF2KEEF2K 0.698 0.034 3 0.592
DAPK3DAPK3 0.698 -0.007 -3 0.726
TAO3TAO3 0.698 -0.037 1 0.688
DYRK4DYRK4 0.698 -0.014 1 0.460
WNK4WNK4 0.697 -0.120 -2 0.403
SMMLCKSMMLCK 0.697 -0.060 -3 0.741
P38BP38B 0.696 -0.047 1 0.454
CDK19CDK19 0.696 -0.076 1 0.445
SNRKSNRK 0.696 -0.154 2 0.668
MAPKAPK5MAPKAPK5 0.696 -0.071 -3 0.661
PKCTPKCT 0.696 -0.051 2 0.748
CDK18CDK18 0.695 -0.049 1 0.426
MST3MST3 0.695 -0.083 2 0.834
CDK5CDK5 0.695 -0.049 1 0.519
SSTKSSTK 0.695 -0.069 4 0.745
DYRK1BDYRK1B 0.695 -0.015 1 0.479
DYRK3DYRK3 0.694 -0.022 1 0.580
MST1MST1 0.694 0.023 1 0.701
DYRK1ADYRK1A 0.694 -0.037 1 0.567
P38DP38D 0.693 -0.024 1 0.416
CAMKK2CAMKK2 0.693 -0.094 -2 0.339
IRAK4IRAK4 0.693 -0.129 1 0.752
NEK11NEK11 0.692 -0.125 1 0.692
LKB1LKB1 0.692 -0.081 -3 0.676
PDK1PDK1 0.692 -0.052 1 0.735
AKT1AKT1 0.691 -0.021 -3 0.649
DAPK1DAPK1 0.691 -0.020 -3 0.728
GSK3AGSK3A 0.691 0.005 4 0.408
CDK13CDK13 0.691 -0.084 1 0.473
MPSK1MPSK1 0.691 -0.055 1 0.742
PAK5PAK5 0.691 -0.060 -2 0.253
CDK7CDK7 0.691 -0.100 1 0.500
JNK1JNK1 0.691 -0.010 1 0.418
CDK2CDK2 0.690 -0.082 1 0.515
CHK2CHK2 0.689 0.014 -3 0.602
PDHK3_TYRPDHK3_TYR 0.689 0.153 4 0.858
GCKGCK 0.689 -0.055 1 0.691
CDK17CDK17 0.688 -0.060 1 0.362
MAP2K6_TYRMAP2K6_TYR 0.688 0.174 -1 0.721
SGK1SGK1 0.688 0.020 -3 0.600
PHKG2PHKG2 0.687 -0.087 -3 0.691
P70S6KP70S6K 0.687 -0.046 -3 0.655
PKCEPKCE 0.687 -0.027 2 0.744
PKCIPKCI 0.687 -0.071 2 0.729
MRCKBMRCKB 0.687 -0.016 -3 0.672
PDHK1_TYRPDHK1_TYR 0.687 0.143 -1 0.740
PAK4PAK4 0.687 -0.059 -2 0.265
ROCK2ROCK2 0.686 -0.010 -3 0.698
HIPK3HIPK3 0.686 -0.076 1 0.567
ALPHAK3ALPHAK3 0.686 0.070 -1 0.649
PDHK4_TYRPDHK4_TYR 0.686 0.140 2 0.866
TAO2TAO2 0.686 -0.116 2 0.819
NEK4NEK4 0.686 -0.131 1 0.726
CAMK1ACAMK1A 0.685 -0.013 -3 0.616
GSK3BGSK3B 0.685 -0.037 4 0.400
TNIKTNIK 0.685 -0.058 3 0.596
CDK3CDK3 0.685 -0.039 1 0.387
MRCKAMRCKA 0.684 -0.027 -3 0.677
CDK12CDK12 0.684 -0.082 1 0.441
MINKMINK 0.684 -0.092 1 0.710
MAP2K4_TYRMAP2K4_TYR 0.684 0.081 -1 0.719
SLKSLK 0.683 -0.057 -2 0.327
IRAK1IRAK1 0.683 -0.210 -1 0.635
MEK2MEK2 0.683 -0.102 2 0.786
OSR1OSR1 0.682 0.029 2 0.798
MAP3K15MAP3K15 0.682 -0.131 1 0.682
CDK14CDK14 0.682 -0.076 1 0.470
NEK1NEK1 0.682 -0.111 1 0.743
TXKTXK 0.681 0.151 1 0.741
CDK9CDK9 0.681 -0.106 1 0.484
STK33STK33 0.681 -0.090 2 0.623
MAKMAK 0.680 -0.005 -2 0.326
LRRK2LRRK2 0.680 -0.143 2 0.795
CDK16CDK16 0.679 -0.055 1 0.385
VRK1VRK1 0.679 -0.151 2 0.785
HGKHGK 0.679 -0.116 3 0.582
SBKSBK 0.679 0.015 -3 0.554
DMPK1DMPK1 0.679 -0.009 -3 0.692
CK1ACK1A 0.679 0.015 -3 0.529
MAP2K7_TYRMAP2K7_TYR 0.679 -0.032 2 0.831
MEKK6MEKK6 0.679 -0.175 1 0.700
BUB1BUB1 0.679 -0.025 -5 0.702
PKN1PKN1 0.679 -0.047 -3 0.653
PBKPBK 0.678 0.001 1 0.762
HPK1HPK1 0.678 -0.105 1 0.678
BLKBLK 0.678 0.145 -1 0.652
LOKLOK 0.678 -0.119 -2 0.333
BMPR2_TYRBMPR2_TYR 0.678 0.027 -1 0.705
AKT3AKT3 0.678 -0.014 -3 0.606
HASPINHASPIN 0.677 0.039 -1 0.764
CK1G3CK1G3 0.677 0.044 -3 0.502
TESK1_TYRTESK1_TYR 0.677 -0.085 3 0.680
RIPK2RIPK2 0.677 -0.174 1 0.669
ERK7ERK7 0.676 -0.061 2 0.485
PINK1_TYRPINK1_TYR 0.676 -0.040 1 0.735
BIKEBIKE 0.676 0.063 1 0.725
KHS2KHS2 0.675 -0.059 1 0.694
KHS1KHS1 0.674 -0.094 1 0.698
CDK10CDK10 0.674 -0.065 1 0.458
PKMYT1_TYRPKMYT1_TYR 0.674 -0.093 3 0.655
PKG1PKG1 0.674 -0.063 -2 0.253
ROCK1ROCK1 0.673 -0.030 -3 0.677
FGRFGR 0.673 0.029 1 0.765
YSK1YSK1 0.672 -0.129 2 0.780
MOKMOK 0.672 -0.029 1 0.606
FYNFYN 0.672 0.117 -1 0.597
ABL2ABL2 0.672 0.016 -1 0.657
FERFER 0.672 0.026 1 0.785
YES1YES1 0.672 0.053 -1 0.666
LCKLCK 0.671 0.070 -1 0.628
SRMSSRMS 0.670 0.058 1 0.760
YANK3YANK3 0.670 -0.025 2 0.390
CRIKCRIK 0.670 -0.007 -3 0.644
EPHA6EPHA6 0.670 -0.017 -1 0.691
EPHA4EPHA4 0.669 0.045 2 0.755
EPHB4EPHB4 0.668 -0.034 -1 0.659
NEK3NEK3 0.668 -0.155 1 0.697
EPHB2EPHB2 0.667 0.047 -1 0.633
RETRET 0.667 -0.109 1 0.716
FLT1FLT1 0.666 0.035 -1 0.683
CK1G2CK1G2 0.666 0.055 -3 0.580
HCKHCK 0.666 0.005 -1 0.627
ABL1ABL1 0.665 -0.021 -1 0.648
CSF1RCSF1R 0.665 -0.049 3 0.582
LIMK2_TYRLIMK2_TYR 0.665 -0.116 -3 0.733
TNK2TNK2 0.664 -0.047 3 0.539
FLT3FLT3 0.664 -0.032 3 0.567
SYKSYK 0.664 0.095 -1 0.600
CDK6CDK6 0.664 -0.090 1 0.463
INSRRINSRR 0.664 -0.009 3 0.550
ASK1ASK1 0.663 -0.128 1 0.671
STLK3STLK3 0.663 -0.059 1 0.653
TECTEC 0.663 0.035 -1 0.571
CDK4CDK4 0.662 -0.093 1 0.430
LIMK1_TYRLIMK1_TYR 0.662 -0.162 2 0.803
MST1RMST1R 0.662 -0.142 3 0.601
KITKIT 0.662 -0.018 3 0.586
AAK1AAK1 0.662 0.088 1 0.642
EPHB3EPHB3 0.662 -0.020 -1 0.634
TYK2TYK2 0.662 -0.170 1 0.728
FRKFRK 0.662 0.019 -1 0.670
EPHB1EPHB1 0.661 -0.019 1 0.751
ITKITK 0.661 0.009 -1 0.608
JAK3JAK3 0.661 -0.076 1 0.699
MYO3AMYO3A 0.661 -0.096 1 0.698
TYRO3TYRO3 0.661 -0.126 3 0.573
LYNLYN 0.661 0.035 3 0.541
JAK2JAK2 0.660 -0.147 1 0.713
ERBB2ERBB2 0.659 -0.024 1 0.666
METMET 0.659 -0.028 3 0.578
MYO3BMYO3B 0.659 -0.117 2 0.789
ROS1ROS1 0.659 -0.130 3 0.549
SRCSRC 0.659 0.055 -1 0.609
EPHA5EPHA5 0.658 0.029 2 0.750
PTK2PTK2 0.658 0.048 -1 0.612
KDRKDR 0.658 -0.072 3 0.560
MERTKMERTK 0.658 -0.044 3 0.601
BMXBMX 0.657 -0.004 -1 0.544
EGFREGFR 0.656 0.034 1 0.571
FGFR2FGFR2 0.656 -0.068 3 0.596
NEK10_TYRNEK10_TYR 0.655 -0.081 1 0.610
PTK6PTK6 0.654 -0.049 -1 0.556
EPHA7EPHA7 0.654 -0.024 2 0.749
EPHA8EPHA8 0.654 0.019 -1 0.626
TAO1TAO1 0.654 -0.138 1 0.646
DDR1DDR1 0.653 -0.183 4 0.779
PDGFRBPDGFRB 0.652 -0.130 3 0.581
FGFR4FGFR4 0.652 0.014 -1 0.615
BTKBTK 0.652 -0.086 -1 0.582
EPHA3EPHA3 0.652 -0.066 2 0.727
FGFR3FGFR3 0.652 -0.034 3 0.578
FLT4FLT4 0.651 -0.061 3 0.575
MATKMATK 0.650 -0.040 -1 0.623
NTRK1NTRK1 0.650 -0.097 -1 0.629
AXLAXL 0.650 -0.131 3 0.580
FGFR1FGFR1 0.650 -0.112 3 0.575
PTK2BPTK2B 0.649 -0.025 -1 0.596
TEKTEK 0.649 -0.111 3 0.530
TNK1TNK1 0.649 -0.126 3 0.576
ERBB4ERBB4 0.649 0.021 1 0.577
CSKCSK 0.648 -0.054 2 0.746
TNNI3K_TYRTNNI3K_TYR 0.645 -0.139 1 0.722
NTRK3NTRK3 0.645 -0.075 -1 0.581
EPHA1EPHA1 0.644 -0.122 3 0.557
JAK1JAK1 0.644 -0.144 1 0.678
WEE1_TYRWEE1_TYR 0.644 -0.115 -1 0.593
NTRK2NTRK2 0.644 -0.119 3 0.565
LTKLTK 0.642 -0.140 3 0.557
EPHA2EPHA2 0.642 -0.004 -1 0.594
PDGFRAPDGFRA 0.642 -0.211 3 0.573
YANK2YANK2 0.640 -0.047 2 0.407
INSRINSR 0.640 -0.112 3 0.534
ALKALK 0.639 -0.162 3 0.518
ZAP70ZAP70 0.637 0.003 -1 0.525
IGF1RIGF1R 0.635 -0.058 3 0.503
FESFES 0.625 -0.081 -1 0.521
DDR2DDR2 0.625 -0.171 3 0.524
MUSKMUSK 0.624 -0.119 1 0.575