Motif 641 (n=277)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S383 | ochoa | Golgin A8 family member Q | None |
| A0A0M3HER8 | GOLGA6L10 | S444 | ochoa | Golgin A6 family like 10 | None |
| A4D2H0 | CTAGE15 | S138 | ochoa | cTAGE family member 15 (Protein cTAGE-15) | None |
| A4FU28 | CTAGE9 | S138 | ochoa | cTAGE family member 9 (Protein cTAGE-9) | None |
| A6NEF3 | GOLGA6L4 | S482 | ochoa | Golgin subfamily A member 6-like protein 4 | None |
| A6NEM1 | GOLGA6L9 | S340 | ochoa | Golgin subfamily A member 6-like protein 9 | None |
| A6NI86 | GOLGA6L10 | S430 | ochoa | Golgin subfamily A member 6-like protein 10 | None |
| H0Y858 | None | S28 | ochoa | Toll-like receptor 9 | None |
| H0YKK7 | GOLGA6L19 | S458 | ochoa | Putative golgin subfamily A member 6-like protein 19 | None |
| H3BSY2 | GOLGA8M | S383 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S382 | ochoa | Golgin subfamily A member 8R | None |
| O00139 | KIF2A | S635 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O14980 | XPO1 | S1031 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15504 | NUP42 | S106 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O43156 | TTI1 | S802 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43290 | SART1 | S521 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O60271 | SPAG9 | S730 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60462 | NRP2 | S901 | ochoa | Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) | High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. {ECO:0000269|PubMed:30057110}. |
| O60826 | CCDC22 | S347 | ochoa | Coiled-coil domain-containing protein 22 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). Involved in regulation of NF-kappa-B signaling (PubMed:23563313). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (PubMed:23563313). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Plays a role in copper ion homeostasis (PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| O75116 | ROCK2 | S937 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75400 | PRPF40A | S938 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75563 | SKAP2 | S203 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75821 | EIF3G | S189 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O94915 | FRYL | S479 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94992 | HEXIM1 | S283 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95235 | KIF20A | S433 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95235 | KIF20A | S685 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95295 | SNAPIN | S50 | psp | SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}. |
| O95613 | PCNT | S813 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S2477 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | Y3306 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95721 | SNAP29 | S77 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| O95816 | BAG2 | S31 | ochoa | BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9873016}. |
| O96017 | CHEK2 | S456 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P01106 | MYC | S388 | psp | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}. |
| P01270 | PTH | S48 | psp | Parathyroid hormone (PTH) (Parathormone) (Parathyrin) | Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed:11604398, PubMed:35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:18375760, PubMed:35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed:21076856). {ECO:0000269|PubMed:11604398, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:35932760}. |
| P05976 | MYL1 | S99 | ochoa | Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2) | Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}. |
| P06753 | TPM3 | Y61 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P06753 | TPM3 | S246 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07195 | LDHB | S44 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07951 | TPM2 | S245 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P08670 | VIM | T336 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09086 | POU2F2 | S250 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P09543 | CNP | S170 | ochoa | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) | Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}. |
| P0CG41 | CTAGE8 | S138 | ochoa | cTAGE family member 8 (Protein cTAGE-8) | None |
| P0DP23 | CALM1 | S102 | ochoa|psp | Calmodulin-1 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:23893133, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. {ECO:0000269|PubMed:31330532}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P0DP24 | CALM2 | S102 | ochoa | Calmodulin-2 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P0DP25 | CALM3 | S102 | ochoa | Calmodulin-3 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P11055 | MYH3 | S1200 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11055 | MYH3 | T1776 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11171 | EPB41 | S664 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12882 | MYH1 | T992 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1069 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1132 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1203 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1611 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1650 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1779 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1199 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1269 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | Y1308 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1463 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1607 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1775 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1201 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1465 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1609 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1777 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S900 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T991 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T1729 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T1778 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14859 | POU2F1 | S335 | ochoa|psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P24539 | ATP5PB | S155 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P25205 | MCM3 | S740 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P30153 | PPP2R1A | S120 | ochoa | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:8694763}. |
| P35579 | MYH9 | S1126 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1660 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1808 | ochoa|psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1667 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36507 | MAP2K2 | S30 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P42566 | EPS15 | S467 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46939 | UTRN | S2111 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46940 | IQGAP1 | S1441 | ochoa|psp | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48681 | NES | T585 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P51956 | NEK3 | S319 | ochoa | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
| P52948 | NUP98 | S704 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54278 | PMS2 | S373 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P60981 | DSTN | S88 | ochoa | Destrin (Actin-depolymerizing factor) (ADF) | Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}. |
| P80303 | NUCB2 | S332 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q03252 | LMNB2 | S134 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q07687 | DLX2 | S127 | ochoa | Homeobox protein DLX-2 | Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}. |
| Q08378 | GOLGA3 | S385 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08378 | GOLGA3 | S1127 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q0ZGT2 | NEXN | S243 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12802 | AKAP13 | S1281 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S692 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12912 | IRAG2 | S345 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13439 | GOLGA4 | S181 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13464 | ROCK1 | S456 | psp | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14155 | ARHGEF7 | S703 | ochoa|psp | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14289 | PTK2B | S839 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14318 | FKBP8 | S281 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14586 | ZNF267 | S229 | ochoa | Zinc finger protein 267 (Zinc finger protein HZF2) | May be involved in transcriptional regulation. |
| Q14789 | GOLGB1 | S2589 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15052 | ARHGEF6 | S649 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15075 | EEA1 | S98 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15149 | PLEC | S4037 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15361 | TTF1 | S487 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q155Q3 | DIXDC1 | S346 | ochoa | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}. |
| Q15643 | TRIP11 | S1341 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15751 | HERC1 | S1558 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15814 | TBCC | S80 | ochoa | Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) | Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}. |
| Q3SXY8 | ARL13B | S148 | ochoa | ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (PubMed:38219074). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (PubMed:23223633). {ECO:0000269|PubMed:23150559, ECO:0000269|PubMed:23223633, ECO:0000269|PubMed:38219074}. |
| Q4V328 | GRIPAP1 | S241 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q52LW3 | ARHGAP29 | S357 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53QZ3 | ARHGAP15 | S64 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5M775 | SPECC1 | S597 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5M775 | SPECC1 | S692 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0W9 | FAM83B | S466 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5TZA2 | CROCC | S1218 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VYK3 | ECPAS | S1826 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q6DN90 | IQSEC1 | S361 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6IBS0 | TWF2 | S167 | ochoa | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
| Q6NTE8 | MRNIP | S100 | psp | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
| Q6NWY9 | PRPF40B | S852 | ochoa | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}. |
| Q6P0N0 | MIS18BP1 | S991 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P996 | PDXDC1 | S537 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6UXY8 | TMC5 | S967 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6ZN28 | MACC1 | S34 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZU80 | CEP128 | S301 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7Z7L8 | C11orf96 | S406 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86T23 | CROCCP2 | S26 | ochoa | Putative ciliary rootlet coiled-coil protein-like 1 protein (Ciliary rootlet coiled-coil protein pseudogene 2) | None |
| Q86UF2 | CTAGE6 | S138 | ochoa | cTAGE family member 6 (Protein cTAGE-6) | None |
| Q86XR8 | CEP57 | S118 | ochoa | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}. |
| Q86XZ4 | SPATS2 | S143 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q86YP4 | GATAD2A | S137 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IUD2 | ERC1 | S688 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IX94 | CTAGE4 | S138 | ochoa | cTAGE family member 4 (Protein cTAGE-4) | Tumor-associated antigen. |
| Q8NF91 | SYNE1 | S8386 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TBA6 | GOLGA5 | S583 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TDW5 | SYTL5 | S482 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8WXD5 | GEMIN6 | S95 | ochoa | Gem-associated protein 6 (Gemin-6) (SIP2) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}. |
| Q8WXH0 | SYNE2 | S5857 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92609 | TBC1D5 | S584 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92878 | RAD50 | S470 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q969Z0 | TBRG4 | S64 | ochoa | FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) | Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}. |
| Q96C92 | ENTR1 | S270 | ochoa | Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3) | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}. |
| Q96KQ7 | EHMT2 | S1187 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96PC5 | MIA2 | S745 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q99576 | TSC22D3 | S102 | ochoa | TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}. |
| Q99661 | KIF2C | S633 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99767 | APBA2 | S208 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BSC4 | NOL10 | S632 | ochoa | Nucleolar protein 10 | None |
| Q9BV73 | CEP250 | S2179 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BYC5 | FUT8 | S39 | ochoa | Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) | Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:29304374, ECO:0000269|PubMed:9133635}. |
| Q9BYM8 | RBCK1 | S333 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BZ29 | DOCK9 | S308 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9BZF9 | UACA | T1232 | ochoa | Uveal autoantigen with coiled-coil domains and ankyrin repeats | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}. |
| Q9H2U1 | DHX36 | S136 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9NP74 | PALMD | S81 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NRL3 | STRN4 | S342 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9NS87 | KIF15 | S1169 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NW97 | TMEM51 | S143 | ochoa | Transmembrane protein 51 | None |
| Q9NWU2 | GID8 | S188 | ochoa | Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). {ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}. |
| Q9P0P0 | RNF181 | S70 | ochoa | E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:18331836). Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749). {ECO:0000269|PubMed:18331836, ECO:0000269|PubMed:24811749}. |
| Q9P1Z2 | CALCOCO1 | S468 | ochoa | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Q9P253 | VPS18 | S829 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9P2F8 | SIPA1L2 | S1650 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBC2 | EPS15L1 | S434 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UKI9 | POU2F3 | S238 | ochoa | POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:11329378, ECO:0000269|PubMed:35576971}. |
| Q9UKV0 | HDAC9 | S491 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9UKX2 | MYH2 | T994 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1071 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1134 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1205 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1613 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1781 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T1779 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UPN3 | MACF1 | S3692 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UQE7 | SMC3 | S886 | ochoa | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y2X3 | NOP58 | S380 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y448 | KNSTRN | S241 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
| Q9Y490 | TLN1 | S604 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B5 | MTCL1 | S651 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y5B0 | CTDP1 | S942 | psp | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9Y5K6 | CD2AP | S582 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y623 | MYH4 | T992 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | S1132 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T1779 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6A5 | TACC3 | S799 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6D9 | MAD1L1 | S490 | ochoa | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6X4 | FAM169A | S358 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| P05023 | ATP1A1 | S519 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| O15020 | SPTBN2 | S1417 | Sugiyama | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| Q01082 | SPTBN1 | S1414 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q08378 | GOLGA3 | S739 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| P33176 | KIF5B | Y649 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P33176 | KIF5B | S663 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| O75676 | RPS6KA4 | S87 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| Q9Y4K3 | TRAF6 | Y326 | SIGNOR | TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19465916, PubMed:19713527, PubMed:27746020, PubMed:31620128). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569). Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271, PubMed:17703191). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:12140561, PubMed:19825828, PubMed:8837778). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Participates also in the TCR signaling by ubiquitinating LAT (PubMed:23514740, PubMed:25907557). {ECO:0000250|UniProtKB:P70196, ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:12140561, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:17135271, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:18347055, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:19465916, ECO:0000269|PubMed:19675569, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:31620128, ECO:0000269|PubMed:8837778}. |
| P34897 | SHMT2 | S81 | Sugiyama | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| Q14980 | NUMA1 | S1181 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q9Y490 | TLN1 | S1535 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S1537 | Sugiyama | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| P22415 | USF1 | Y250 | Sugiyama | Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| O75347 | TBCA | S60 | Sugiyama | Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) | Tubulin-folding protein; involved in the early step of the tubulin folding pathway. |
| O43293 | DAPK3 | S318 | GPS6|EPSD | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| P20700 | LMNB1 | Y138 | Sugiyama | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| Q00534 | CDK6 | Y299 | Sugiyama | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q9GZM8 | NDEL1 | S166 | PSP | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| P20810 | CAST | S287 | Sugiyama | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| Q6PHR2 | ULK3 | S300 | GPS6|SIGNOR|EPSD|PSP | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q02818 | NUCB1 | S378 | Sugiyama | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q9Y388 | RBMX2 | S227 | Sugiyama | RNA-binding motif protein, X-linked 2 | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q08378 | GOLGA3 | S476 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| O60271 | SPAG9 | T423 | Sugiyama | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| Q9P2E9 | RRBP1 | S1321 | Sugiyama | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q08378 | GOLGA3 | S1036 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q13439 | GOLGA4 | S993 | Sugiyama | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q9UHD2 | TBK1 | S348 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| O00592 | PODXL | S519 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O15516 | CLOCK | S406 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O75116 | ROCK2 | S930 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O95239 | KIF4A | S887 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| P01241 | GH1 | S132 | psp | Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
| P02545 | LMNA | S295 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S326 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P07951 | TPM2 | S63 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P12081 | HARS1 | S27 | ochoa | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) | Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). {ECO:0000269|PubMed:26072516, ECO:0000269|PubMed:29235198}. |
| P12270 | TPR | S829 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12882 | MYH1 | S1702 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1698 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1700 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P20810 | CAST | S311 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P36402 | TCF7 | S40 | ochoa | Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1) | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. {ECO:0000250|UniProtKB:Q00417}. |
| P36507 | MAP2K2 | S26 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P48681 | NES | S578 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S610 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P57737 | CORO7 | S613 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| Q03188 | CENPC | S110 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08AD1 | CAMSAP2 | S901 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13561 | DCTN2 | S127 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13568 | IRF5 | S446 | ochoa|psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
| Q13813 | SPTAN1 | S484 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13813 | SPTAN1 | S1231 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13813 | SPTAN1 | S1302 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14573 | ITPR3 | S954 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14789 | GOLGB1 | S3075 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15149 | PLEC | S1732 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q5M775 | SPECC1 | S425 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SXM2 | SNAPC4 | S1394 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SXM2 | SNAPC4 | S1398 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q6IQ55 | TTBK2 | S794 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6UXH0 | ANGPTL8 | S94 | psp | Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein) | Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). {ECO:0000250|UniProtKB:Q8R1L8, ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23150577}. |
| Q6WKZ4 | RAB11FIP1 | S315 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZU80 | CEP128 | S961 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q86V48 | LUZP1 | S57 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8WUR7 | C15orf40 | S116 | ochoa | UPF0235 protein C15orf40 | None |
| Q8WVV4 | POF1B | S495 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WYK2 | JDP2 | S145 | ochoa | Jun dimerization protein 2 | Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}. |
| Q96NT1 | NAP1L5 | S76 | ochoa | Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy) | None |
| Q99614 | TTC1 | S89 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q9BRK4 | LZTS2 | S346 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BXL6 | CARD14 | S290 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9NTJ3 | SMC4 | S982 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9P0J7 | KCMF1 | S219 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9UKX2 | MYH2 | S1704 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9Y5Q9 | GTF3C3 | S495 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| P33991 | MCM4 | S469 | Sugiyama | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q9UBC2 | EPS15L1 | S518 | Sugiyama | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| P49321 | NASP | S659 | Sugiyama | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| O43896 | KIF1C | S684 | Sugiyama | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| P09211 | GSTP1 | S66 | Sugiyama | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| Q5T9S5 | CCDC18 | S336 | Sugiyama | Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) | None |
| Q86UP2 | KTN1 | S1181 | Sugiyama | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q8IX12 | CCAR1 | S1075 | Sugiyama | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 1.529477e-08 | 7.815 |
| R-HSA-68886 | M Phase | 5.174034e-08 | 7.286 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.234518e-08 | 7.141 |
| R-HSA-68877 | Mitotic Prometaphase | 9.022015e-07 | 6.045 |
| R-HSA-390522 | Striated Muscle Contraction | 2.854866e-06 | 5.544 |
| R-HSA-68875 | Mitotic Prophase | 6.741661e-06 | 5.171 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.238448e-06 | 5.140 |
| R-HSA-983189 | Kinesins | 9.998276e-06 | 5.000 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.624198e-05 | 4.581 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.017259e-05 | 4.520 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.640609e-05 | 4.178 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 8.411171e-05 | 4.075 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.600369e-05 | 4.018 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.600369e-05 | 4.018 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.606810e-04 | 3.794 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.775619e-04 | 3.751 |
| R-HSA-199991 | Membrane Trafficking | 1.857828e-04 | 3.731 |
| R-HSA-75153 | Apoptotic execution phase | 1.775619e-04 | 3.751 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.255324e-04 | 3.647 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.555674e-04 | 3.592 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.555674e-04 | 3.592 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.193911e-04 | 3.659 |
| R-HSA-397014 | Muscle contraction | 2.164484e-04 | 3.665 |
| R-HSA-68882 | Mitotic Anaphase | 2.523761e-04 | 3.598 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.621118e-04 | 3.582 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.297407e-04 | 3.639 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.441623e-04 | 3.612 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.246579e-04 | 3.489 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.246579e-04 | 3.489 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.930239e-04 | 3.533 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.123839e-04 | 3.505 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.640898e-04 | 3.439 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.640898e-04 | 3.439 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.070382e-04 | 3.390 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.255779e-04 | 3.371 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.537029e-04 | 3.343 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 4.822582e-04 | 3.317 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 4.822582e-04 | 3.317 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.152758e-04 | 3.288 |
| R-HSA-191859 | snRNP Assembly | 5.525465e-04 | 3.258 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.525465e-04 | 3.258 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 5.761101e-04 | 3.239 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.590002e-04 | 3.253 |
| R-HSA-373753 | Nephrin family interactions | 5.761101e-04 | 3.239 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.816608e-04 | 3.166 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.816608e-04 | 3.166 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 7.500435e-04 | 3.125 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 7.500435e-04 | 3.125 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.153592e-04 | 3.089 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 7.659125e-04 | 3.116 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 8.234231e-04 | 3.084 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 9.585456e-04 | 3.018 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.025423e-03 | 2.989 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.214827e-03 | 2.915 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.271033e-03 | 2.896 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.595047e-03 | 2.797 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.780702e-03 | 2.749 |
| R-HSA-4641265 | Repression of WNT target genes | 1.850363e-03 | 2.733 |
| R-HSA-1221632 | Meiotic synapsis | 2.338230e-03 | 2.631 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 2.195458e-03 | 2.658 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.338230e-03 | 2.631 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 2.577987e-03 | 2.589 |
| R-HSA-1500620 | Meiosis | 2.879926e-03 | 2.541 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.719486e-03 | 2.566 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.179315e-03 | 2.498 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.532290e-03 | 2.452 |
| R-HSA-373760 | L1CAM interactions | 3.573797e-03 | 2.447 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.896881e-03 | 2.409 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.938203e-03 | 2.405 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.436770e-03 | 2.353 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.436770e-03 | 2.353 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.182184e-03 | 2.379 |
| R-HSA-373755 | Semaphorin interactions | 4.436770e-03 | 2.353 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.978743e-03 | 2.303 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.094748e-03 | 2.293 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 5.094748e-03 | 2.293 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.266620e-03 | 2.278 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.455318e-03 | 2.190 |
| R-HSA-109581 | Apoptosis | 5.913719e-03 | 2.228 |
| R-HSA-70171 | Glycolysis | 6.696551e-03 | 2.174 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 6.919277e-03 | 2.160 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.245562e-03 | 2.140 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.276235e-03 | 2.138 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.619542e-03 | 2.118 |
| R-HSA-380287 | Centrosome maturation | 8.407433e-03 | 2.075 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.619542e-03 | 2.118 |
| R-HSA-4086398 | Ca2+ pathway | 7.619542e-03 | 2.118 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 8.407433e-03 | 2.075 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.994371e-03 | 2.046 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.994371e-03 | 2.046 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.994371e-03 | 2.046 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.994371e-03 | 2.046 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.058094e-02 | 1.975 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.062048e-02 | 1.974 |
| R-HSA-416482 | G alpha (12/13) signalling events | 9.692458e-03 | 2.014 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.058094e-02 | 1.975 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.048372e-02 | 1.979 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.048372e-02 | 1.979 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.112894e-02 | 1.954 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.160755e-02 | 1.935 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.245276e-02 | 1.905 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.259726e-02 | 1.900 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.265530e-02 | 1.898 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.320242e-02 | 1.879 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.351123e-02 | 1.869 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.351123e-02 | 1.869 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.405155e-02 | 1.852 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.577766e-02 | 1.802 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.577766e-02 | 1.802 |
| R-HSA-176974 | Unwinding of DNA | 1.405155e-02 | 1.852 |
| R-HSA-177929 | Signaling by EGFR | 1.584293e-02 | 1.800 |
| R-HSA-5617833 | Cilium Assembly | 1.363966e-02 | 1.865 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.584293e-02 | 1.800 |
| R-HSA-70326 | Glucose metabolism | 1.422505e-02 | 1.847 |
| R-HSA-3371556 | Cellular response to heat stress | 1.624086e-02 | 1.789 |
| R-HSA-162587 | HIV Life Cycle | 1.649935e-02 | 1.783 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.698611e-02 | 1.770 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.787654e-02 | 1.748 |
| R-HSA-182971 | EGFR downregulation | 1.824498e-02 | 1.739 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.885747e-02 | 1.725 |
| R-HSA-194138 | Signaling by VEGF | 1.902775e-02 | 1.721 |
| R-HSA-5357801 | Programmed Cell Death | 2.020216e-02 | 1.695 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.091443e-02 | 1.680 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.132885e-02 | 1.671 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.235772e-02 | 1.651 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.686146e-02 | 1.571 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.686146e-02 | 1.571 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.259719e-02 | 1.646 |
| R-HSA-5673000 | RAF activation | 2.378661e-02 | 1.624 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.686146e-02 | 1.571 |
| R-HSA-1474165 | Reproduction | 2.278282e-02 | 1.642 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.751604e-02 | 1.560 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.847472e-02 | 1.546 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 2.924946e-02 | 1.534 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 2.924946e-02 | 1.534 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.984006e-02 | 1.525 |
| R-HSA-1170546 | Prolactin receptor signaling | 2.984006e-02 | 1.525 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.984006e-02 | 1.525 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.985044e-02 | 1.525 |
| R-HSA-1500931 | Cell-Cell communication | 2.985045e-02 | 1.525 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.106028e-02 | 1.508 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.196329e-02 | 1.495 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.343916e-02 | 1.476 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.343916e-02 | 1.476 |
| R-HSA-211000 | Gene Silencing by RNA | 3.343916e-02 | 1.476 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.356561e-02 | 1.474 |
| R-HSA-9646399 | Aggrephagy | 3.361619e-02 | 1.473 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.361619e-02 | 1.473 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.729328e-02 | 1.428 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.033117e-02 | 1.394 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.753865e-02 | 1.426 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.597894e-02 | 1.444 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.729328e-02 | 1.428 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.786454e-02 | 1.422 |
| R-HSA-69275 | G2/M Transition | 3.470955e-02 | 1.460 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.626400e-02 | 1.441 |
| R-HSA-9659379 | Sensory processing of sound | 4.177063e-02 | 1.379 |
| R-HSA-162582 | Signal Transduction | 3.437190e-02 | 1.464 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 4.290089e-02 | 1.368 |
| R-HSA-9675108 | Nervous system development | 3.686881e-02 | 1.433 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 4.355311e-02 | 1.361 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 4.355311e-02 | 1.361 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 4.355311e-02 | 1.361 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 4.355311e-02 | 1.361 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 4.355311e-02 | 1.361 |
| R-HSA-422475 | Axon guidance | 4.453507e-02 | 1.351 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.458595e-02 | 1.351 |
| R-HSA-73887 | Death Receptor Signaling | 4.471961e-02 | 1.350 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.471961e-02 | 1.350 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 4.644418e-02 | 1.333 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.843720e-02 | 1.315 |
| R-HSA-9679506 | SARS-CoV Infections | 5.011314e-02 | 1.300 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.049948e-02 | 1.297 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.383701e-02 | 1.269 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.394692e-02 | 1.268 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.432090e-02 | 1.265 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 5.764686e-02 | 1.239 |
| R-HSA-9675132 | Diseases of cellular response to stress | 5.764686e-02 | 1.239 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 5.764686e-02 | 1.239 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 5.767906e-02 | 1.239 |
| R-HSA-9663891 | Selective autophagy | 5.774414e-02 | 1.238 |
| R-HSA-69481 | G2/M Checkpoints | 6.204080e-02 | 1.207 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.492895e-02 | 1.188 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 8.521693e-02 | 1.069 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 6.563639e-02 | 1.183 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 8.696465e-02 | 1.061 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 7.620387e-02 | 1.118 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.889213e-02 | 1.103 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 8.521693e-02 | 1.069 |
| R-HSA-982772 | Growth hormone receptor signaling | 6.974469e-02 | 1.156 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 7.153380e-02 | 1.145 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 8.521693e-02 | 1.069 |
| R-HSA-5578775 | Ion homeostasis | 7.095265e-02 | 1.149 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 7.153380e-02 | 1.145 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.270720e-02 | 1.082 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 7.820377e-02 | 1.107 |
| R-HSA-162906 | HIV Infection | 7.728546e-02 | 1.112 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.943090e-02 | 1.100 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.943090e-02 | 1.100 |
| R-HSA-193648 | NRAGE signals death through JNK | 7.095265e-02 | 1.149 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 8.162139e-02 | 1.088 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 8.162139e-02 | 1.088 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 8.162139e-02 | 1.088 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 8.162139e-02 | 1.088 |
| R-HSA-168255 | Influenza Infection | 7.663107e-02 | 1.116 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 8.162139e-02 | 1.088 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 8.720051e-02 | 1.059 |
| R-HSA-9707616 | Heme signaling | 8.720051e-02 | 1.059 |
| R-HSA-8939211 | ESR-mediated signaling | 9.058229e-02 | 1.043 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.183169e-02 | 1.037 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 9.869924e-02 | 1.006 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 9.869924e-02 | 1.006 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.379704e-01 | 0.860 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.379704e-01 | 0.860 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.506783e-01 | 0.822 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.631997e-01 | 0.787 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.631997e-01 | 0.787 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.755373e-01 | 0.756 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.755373e-01 | 0.756 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.755373e-01 | 0.756 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.876937e-01 | 0.727 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.876937e-01 | 0.727 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.876937e-01 | 0.727 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.996716e-01 | 0.700 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.996716e-01 | 0.700 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.996716e-01 | 0.700 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.114736e-01 | 0.675 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.114736e-01 | 0.675 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.114736e-01 | 0.675 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.114736e-01 | 0.675 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.114736e-01 | 0.675 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.114736e-01 | 0.675 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.114736e-01 | 0.675 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.231022e-01 | 0.651 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.231022e-01 | 0.651 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.345601e-01 | 0.630 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.458497e-01 | 0.609 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.458497e-01 | 0.609 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.569735e-01 | 0.590 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.679339e-01 | 0.572 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.679339e-01 | 0.572 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.787333e-01 | 0.555 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.862813e-01 | 0.730 |
| R-HSA-774815 | Nucleosome assembly | 1.862813e-01 | 0.730 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.684954e-01 | 0.773 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.006181e-01 | 0.997 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.506783e-01 | 0.822 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.018232e-01 | 0.992 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.755373e-01 | 0.756 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.809701e-01 | 0.742 |
| R-HSA-69236 | G1 Phase | 1.809701e-01 | 0.742 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 9.869924e-02 | 1.006 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.294129e-01 | 0.639 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 9.869924e-02 | 1.006 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.119837e-01 | 0.951 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.506783e-01 | 0.822 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.631997e-01 | 0.787 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.996716e-01 | 0.700 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.996716e-01 | 0.700 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.114736e-01 | 0.675 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.458497e-01 | 0.609 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.458497e-01 | 0.609 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.869924e-02 | 1.006 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.876937e-01 | 0.727 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.458497e-01 | 0.609 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.679339e-01 | 0.572 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.345601e-01 | 0.630 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.862813e-01 | 0.730 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.394972e-01 | 0.855 |
| R-HSA-111957 | Cam-PDE 1 activation | 1.119837e-01 | 0.951 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.876937e-01 | 0.727 |
| R-HSA-4839744 | Signaling by APC mutants | 1.876937e-01 | 0.727 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.996716e-01 | 0.700 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.996716e-01 | 0.700 |
| R-HSA-202670 | ERKs are inactivated | 1.996716e-01 | 0.700 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.996716e-01 | 0.700 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.231022e-01 | 0.651 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.231022e-01 | 0.651 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.345601e-01 | 0.630 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.787333e-01 | 0.555 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.237896e-01 | 0.907 |
| R-HSA-112043 | PLC beta mediated events | 2.731228e-01 | 0.564 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.785923e-01 | 0.555 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.679339e-01 | 0.572 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.679339e-01 | 0.572 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.787333e-01 | 0.555 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.996716e-01 | 0.700 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.679339e-01 | 0.572 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.394972e-01 | 0.855 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.916143e-01 | 0.718 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.119837e-01 | 0.951 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.755373e-01 | 0.756 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.996716e-01 | 0.700 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.996716e-01 | 0.700 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2.231022e-01 | 0.651 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.458497e-01 | 0.609 |
| R-HSA-111885 | Opioid Signalling | 2.443000e-01 | 0.612 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.009748e-01 | 0.996 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.245057e-01 | 0.905 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.132125e-01 | 0.671 |
| R-HSA-75893 | TNF signaling | 2.457756e-01 | 0.609 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.037160e-01 | 0.691 |
| R-HSA-170968 | Frs2-mediated activation | 2.231022e-01 | 0.651 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.023389e-01 | 0.694 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.496675e-01 | 0.825 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.370478e-01 | 0.863 |
| R-HSA-195721 | Signaling by WNT | 1.036782e-01 | 0.984 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.250731e-01 | 0.903 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.631997e-01 | 0.787 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.833459e-01 | 0.737 |
| R-HSA-447038 | NrCAM interactions | 9.869924e-02 | 1.006 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.631997e-01 | 0.787 |
| R-HSA-425561 | Sodium/Calcium exchangers | 1.996716e-01 | 0.700 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.231022e-01 | 0.651 |
| R-HSA-180024 | DARPP-32 events | 9.600262e-02 | 1.018 |
| R-HSA-418360 | Platelet calcium homeostasis | 9.600262e-02 | 1.018 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 2.458497e-01 | 0.609 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.569735e-01 | 0.590 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.173464e-01 | 0.931 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.239745e-01 | 0.650 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.720561e-01 | 0.565 |
| R-HSA-9612973 | Autophagy | 2.597002e-01 | 0.586 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.720561e-01 | 0.565 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.521870e-01 | 0.598 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.916073e-02 | 1.004 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.148168e-01 | 0.940 |
| R-HSA-437239 | Recycling pathway of L1 | 1.969675e-01 | 0.706 |
| R-HSA-169893 | Prolonged ERK activation events | 2.569735e-01 | 0.590 |
| R-HSA-9675135 | Diseases of DNA repair | 1.916143e-01 | 0.718 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.119837e-01 | 0.951 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.631997e-01 | 0.787 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.631997e-01 | 0.787 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.876937e-01 | 0.727 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.114736e-01 | 0.675 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.114736e-01 | 0.675 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.114736e-01 | 0.675 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.231022e-01 | 0.651 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.787333e-01 | 0.555 |
| R-HSA-1632852 | Macroautophagy | 2.092001e-01 | 0.679 |
| R-HSA-69206 | G1/S Transition | 1.564384e-01 | 0.806 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.755373e-01 | 0.756 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.679339e-01 | 0.572 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 2.787333e-01 | 0.555 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.704205e-01 | 0.768 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.640852e-01 | 0.578 |
| R-HSA-9609690 | HCMV Early Events | 2.168178e-01 | 0.664 |
| R-HSA-69242 | S Phase | 2.341137e-01 | 0.631 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.239745e-01 | 0.650 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.443000e-01 | 0.612 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.785923e-01 | 0.555 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.169647e-01 | 0.932 |
| R-HSA-69190 | DNA strand elongation | 1.100279e-01 | 0.958 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.631997e-01 | 0.787 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.458497e-01 | 0.609 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.569735e-01 | 0.590 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.651860e-01 | 0.782 |
| R-HSA-168256 | Immune System | 1.509611e-01 | 0.821 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.876937e-01 | 0.727 |
| R-HSA-8876725 | Protein methylation | 2.458497e-01 | 0.609 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.068943e-01 | 0.971 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.757510e-01 | 0.755 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.876937e-01 | 0.727 |
| R-HSA-9610379 | HCMV Late Events | 1.211153e-01 | 0.917 |
| R-HSA-111458 | Formation of apoptosome | 1.755373e-01 | 0.756 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.458497e-01 | 0.609 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.344712e-01 | 0.871 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.613308e-01 | 0.792 |
| R-HSA-418346 | Platelet homeostasis | 2.561446e-01 | 0.592 |
| R-HSA-450294 | MAP kinase activation | 2.731228e-01 | 0.564 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.569735e-01 | 0.590 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.496675e-01 | 0.825 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.996716e-01 | 0.700 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.394972e-01 | 0.855 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.274688e-01 | 0.895 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.809701e-01 | 0.742 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.303585e-01 | 0.885 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.384648e-01 | 0.859 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.239745e-01 | 0.650 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.170520e-01 | 0.663 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.478604e-01 | 0.830 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.517275e-01 | 0.819 |
| R-HSA-2262752 | Cellular responses to stress | 1.420974e-01 | 0.847 |
| R-HSA-913531 | Interferon Signaling | 2.537171e-01 | 0.596 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.641590e-02 | 1.016 |
| R-HSA-449147 | Signaling by Interleukins | 2.542808e-01 | 0.595 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.170520e-01 | 0.663 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.457756e-01 | 0.609 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.239745e-01 | 0.650 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.030957e-01 | 0.692 |
| R-HSA-72306 | tRNA processing | 1.520181e-01 | 0.818 |
| R-HSA-5619102 | SLC transporter disorders | 1.428704e-01 | 0.845 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.840598e-01 | 0.547 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.880716e-01 | 0.540 |
| R-HSA-5358508 | Mismatch Repair | 2.893740e-01 | 0.539 |
| R-HSA-3928664 | Ephrin signaling | 2.893740e-01 | 0.539 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.893740e-01 | 0.539 |
| R-HSA-163615 | PKA activation | 2.893740e-01 | 0.539 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.893740e-01 | 0.539 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.893740e-01 | 0.539 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.895221e-01 | 0.538 |
| R-HSA-8953854 | Metabolism of RNA | 2.915111e-01 | 0.535 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.949802e-01 | 0.530 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.998584e-01 | 0.523 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.998584e-01 | 0.523 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.998584e-01 | 0.523 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.998584e-01 | 0.523 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.998584e-01 | 0.523 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.998584e-01 | 0.523 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.004323e-01 | 0.522 |
| R-HSA-112040 | G-protein mediated events | 3.058776e-01 | 0.514 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.101887e-01 | 0.508 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.101887e-01 | 0.508 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.101887e-01 | 0.508 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.101887e-01 | 0.508 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.101887e-01 | 0.508 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.101887e-01 | 0.508 |
| R-HSA-445144 | Signal transduction by L1 | 3.101887e-01 | 0.508 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.101887e-01 | 0.508 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.101887e-01 | 0.508 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.203672e-01 | 0.494 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.203672e-01 | 0.494 |
| R-HSA-198753 | ERK/MAPK targets | 3.203672e-01 | 0.494 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 3.203672e-01 | 0.494 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.221621e-01 | 0.492 |
| R-HSA-448424 | Interleukin-17 signaling | 3.221621e-01 | 0.492 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.275702e-01 | 0.485 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.303962e-01 | 0.481 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.303962e-01 | 0.481 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.303962e-01 | 0.481 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.303962e-01 | 0.481 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.303962e-01 | 0.481 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.303962e-01 | 0.481 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.303962e-01 | 0.481 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.303962e-01 | 0.481 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.329667e-01 | 0.478 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.383509e-01 | 0.471 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.383509e-01 | 0.471 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.402778e-01 | 0.468 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.402778e-01 | 0.468 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.402778e-01 | 0.468 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 3.402778e-01 | 0.468 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.402778e-01 | 0.468 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.402778e-01 | 0.468 |
| R-HSA-2559583 | Cellular Senescence | 3.422946e-01 | 0.466 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.425426e-01 | 0.465 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.500142e-01 | 0.456 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.544215e-01 | 0.450 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.596074e-01 | 0.444 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 3.596074e-01 | 0.444 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.596074e-01 | 0.444 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.638306e-01 | 0.439 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.690597e-01 | 0.433 |
| R-HSA-9620244 | Long-term potentiation | 3.690597e-01 | 0.433 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.690597e-01 | 0.433 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.690597e-01 | 0.433 |
| R-HSA-9609646 | HCMV Infection | 3.726022e-01 | 0.429 |
| R-HSA-5576891 | Cardiac conduction | 3.726160e-01 | 0.429 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.756301e-01 | 0.425 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.756301e-01 | 0.425 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.783730e-01 | 0.422 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.783730e-01 | 0.422 |
| R-HSA-525793 | Myogenesis | 3.783730e-01 | 0.422 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.783730e-01 | 0.422 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.783730e-01 | 0.422 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.808886e-01 | 0.419 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.861284e-01 | 0.413 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.875494e-01 | 0.412 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.875494e-01 | 0.412 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.875494e-01 | 0.412 |
| R-HSA-8949613 | Cristae formation | 3.875494e-01 | 0.412 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.875494e-01 | 0.412 |
| R-HSA-264876 | Insulin processing | 3.875494e-01 | 0.412 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.875494e-01 | 0.412 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.891007e-01 | 0.410 |
| R-HSA-163685 | Integration of energy metabolism | 3.965516e-01 | 0.402 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.965910e-01 | 0.402 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.965910e-01 | 0.402 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.965910e-01 | 0.402 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.965910e-01 | 0.402 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.965910e-01 | 0.402 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.965910e-01 | 0.402 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 3.965910e-01 | 0.402 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.965910e-01 | 0.402 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.965910e-01 | 0.402 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.017299e-01 | 0.396 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.054995e-01 | 0.392 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.054995e-01 | 0.392 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.054995e-01 | 0.392 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.120271e-01 | 0.385 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.142771e-01 | 0.383 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.142771e-01 | 0.383 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.142771e-01 | 0.383 |
| R-HSA-1643685 | Disease | 4.165356e-01 | 0.380 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.171430e-01 | 0.380 |
| R-HSA-70268 | Pyruvate metabolism | 4.171430e-01 | 0.380 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.171430e-01 | 0.380 |
| R-HSA-1280218 | Adaptive Immune System | 4.172018e-01 | 0.380 |
| R-HSA-109582 | Hemostasis | 4.178817e-01 | 0.379 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.229257e-01 | 0.374 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.229257e-01 | 0.374 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.229257e-01 | 0.374 |
| R-HSA-72172 | mRNA Splicing | 4.255890e-01 | 0.371 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.314470e-01 | 0.365 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.314470e-01 | 0.365 |
| R-HSA-1538133 | G0 and Early G1 | 4.314470e-01 | 0.365 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.334958e-01 | 0.363 |
| R-HSA-354192 | Integrin signaling | 4.398431e-01 | 0.357 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.398431e-01 | 0.357 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.398431e-01 | 0.357 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.398431e-01 | 0.357 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.398431e-01 | 0.357 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.398431e-01 | 0.357 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.398431e-01 | 0.357 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.398431e-01 | 0.357 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.398431e-01 | 0.357 |
| R-HSA-391251 | Protein folding | 4.473530e-01 | 0.349 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.474790e-01 | 0.349 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.481157e-01 | 0.349 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.481157e-01 | 0.349 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.481157e-01 | 0.349 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.481157e-01 | 0.349 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.523032e-01 | 0.345 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.523032e-01 | 0.345 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.562666e-01 | 0.341 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.562666e-01 | 0.341 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.562666e-01 | 0.341 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.562666e-01 | 0.341 |
| R-HSA-203615 | eNOS activation | 4.562666e-01 | 0.341 |
| R-HSA-5205647 | Mitophagy | 4.562666e-01 | 0.341 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.562666e-01 | 0.341 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.562666e-01 | 0.341 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 4.562666e-01 | 0.341 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.621277e-01 | 0.335 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.642976e-01 | 0.333 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.642976e-01 | 0.333 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.642976e-01 | 0.333 |
| R-HSA-187687 | Signalling to ERKs | 4.642976e-01 | 0.333 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.642976e-01 | 0.333 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.666208e-01 | 0.331 |
| R-HSA-111997 | CaM pathway | 4.722105e-01 | 0.326 |
| R-HSA-111933 | Calmodulin induced events | 4.722105e-01 | 0.326 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.800070e-01 | 0.319 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 4.800070e-01 | 0.319 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.800070e-01 | 0.319 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.814643e-01 | 0.317 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.814643e-01 | 0.317 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.814643e-01 | 0.317 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.814643e-01 | 0.317 |
| R-HSA-422356 | Regulation of insulin secretion | 4.814643e-01 | 0.317 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.865039e-01 | 0.313 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.876887e-01 | 0.312 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.876887e-01 | 0.312 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.929163e-01 | 0.307 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.952575e-01 | 0.305 |
| R-HSA-9648002 | RAS processing | 4.952575e-01 | 0.305 |
| R-HSA-69541 | Stabilization of p53 | 4.952575e-01 | 0.305 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.952575e-01 | 0.305 |
| R-HSA-201556 | Signaling by ALK | 4.952575e-01 | 0.305 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.952575e-01 | 0.305 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.956844e-01 | 0.305 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.003694e-01 | 0.301 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.003694e-01 | 0.301 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.027149e-01 | 0.299 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.027149e-01 | 0.299 |
| R-HSA-167169 | HIV Transcription Elongation | 5.027149e-01 | 0.299 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.027149e-01 | 0.299 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.027149e-01 | 0.299 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.027149e-01 | 0.299 |
| R-HSA-8982491 | Glycogen metabolism | 5.027149e-01 | 0.299 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 5.027149e-01 | 0.299 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.027149e-01 | 0.299 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.096555e-01 | 0.293 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.100626e-01 | 0.292 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.100626e-01 | 0.292 |
| R-HSA-9694548 | Maturation of spike protein | 5.100626e-01 | 0.292 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.100626e-01 | 0.292 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.233721e-01 | 0.281 |
| R-HSA-111996 | Ca-dependent events | 5.244353e-01 | 0.280 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.244353e-01 | 0.280 |
| R-HSA-69239 | Synthesis of DNA | 5.278870e-01 | 0.277 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.314633e-01 | 0.275 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.314633e-01 | 0.275 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.323729e-01 | 0.274 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.323729e-01 | 0.274 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.364470e-01 | 0.270 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.368298e-01 | 0.270 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.368298e-01 | 0.270 |
| R-HSA-5683826 | Surfactant metabolism | 5.383880e-01 | 0.269 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.383880e-01 | 0.269 |
| R-HSA-157118 | Signaling by NOTCH | 5.399041e-01 | 0.268 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.434957e-01 | 0.265 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.434957e-01 | 0.265 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.434957e-01 | 0.265 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.452107e-01 | 0.263 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.452107e-01 | 0.263 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.452107e-01 | 0.263 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.452107e-01 | 0.263 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.452107e-01 | 0.263 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.452107e-01 | 0.263 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.469969e-01 | 0.262 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.519330e-01 | 0.258 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.519330e-01 | 0.258 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.519330e-01 | 0.258 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.519330e-01 | 0.258 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.585563e-01 | 0.253 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.585563e-01 | 0.253 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.586749e-01 | 0.253 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.622569e-01 | 0.250 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.629554e-01 | 0.250 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.650821e-01 | 0.248 |
| R-HSA-5620924 | Intraflagellar transport | 5.650821e-01 | 0.248 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 5.650821e-01 | 0.248 |
| R-HSA-425410 | Metal ion SLC transporters | 5.650821e-01 | 0.248 |
| R-HSA-6798695 | Neutrophil degranulation | 5.666935e-01 | 0.247 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.714272e-01 | 0.243 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.714272e-01 | 0.243 |
| R-HSA-9766229 | Degradation of CDH1 | 5.715119e-01 | 0.243 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.715119e-01 | 0.243 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.715119e-01 | 0.243 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.797798e-01 | 0.237 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.797798e-01 | 0.237 |
| R-HSA-5693538 | Homology Directed Repair | 5.839113e-01 | 0.234 |
| R-HSA-912446 | Meiotic recombination | 5.840888e-01 | 0.234 |
| R-HSA-2514856 | The phototransduction cascade | 5.840888e-01 | 0.234 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.880129e-01 | 0.231 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.880129e-01 | 0.231 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.902387e-01 | 0.229 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.902387e-01 | 0.229 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.902387e-01 | 0.229 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.902387e-01 | 0.229 |
| R-HSA-73886 | Chromosome Maintenance | 5.961264e-01 | 0.225 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.962980e-01 | 0.225 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.962980e-01 | 0.225 |
| R-HSA-983712 | Ion channel transport | 5.975811e-01 | 0.224 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.001382e-01 | 0.222 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.001382e-01 | 0.222 |
| R-HSA-72649 | Translation initiation complex formation | 6.022682e-01 | 0.220 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.022682e-01 | 0.220 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.041201e-01 | 0.219 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.066188e-01 | 0.217 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.081503e-01 | 0.216 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.081503e-01 | 0.216 |
| R-HSA-9753281 | Paracetamol ADME | 6.081503e-01 | 0.216 |
| R-HSA-9012852 | Signaling by NOTCH3 | 6.081503e-01 | 0.216 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.139459e-01 | 0.212 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.139459e-01 | 0.212 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.139459e-01 | 0.212 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.139459e-01 | 0.212 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.196561e-01 | 0.208 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.197485e-01 | 0.208 |
| R-HSA-114608 | Platelet degranulation | 6.235810e-01 | 0.205 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.248372e-01 | 0.204 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.252822e-01 | 0.204 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.273836e-01 | 0.202 |
| R-HSA-168249 | Innate Immune System | 6.292386e-01 | 0.201 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.308254e-01 | 0.200 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.348997e-01 | 0.197 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.362869e-01 | 0.196 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.362869e-01 | 0.196 |
| R-HSA-156590 | Glutathione conjugation | 6.362869e-01 | 0.196 |
| R-HSA-379724 | tRNA Aminoacylation | 6.362869e-01 | 0.196 |
| R-HSA-9824446 | Viral Infection Pathways | 6.388877e-01 | 0.195 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.413601e-01 | 0.193 |
| R-HSA-9640148 | Infection with Enterobacteria | 6.413601e-01 | 0.193 |
| R-HSA-9909396 | Circadian clock | 6.459515e-01 | 0.190 |
| R-HSA-446728 | Cell junction organization | 6.468305e-01 | 0.189 |
| R-HSA-5663205 | Infectious disease | 6.469560e-01 | 0.189 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.495764e-01 | 0.187 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.521934e-01 | 0.186 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.521934e-01 | 0.186 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.545411e-01 | 0.184 |
| R-HSA-9658195 | Leishmania infection | 6.545411e-01 | 0.184 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.573401e-01 | 0.182 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.723296e-01 | 0.172 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.733482e-01 | 0.172 |
| R-HSA-167172 | Transcription of the HIV genome | 6.771795e-01 | 0.169 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.771795e-01 | 0.169 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.775240e-01 | 0.169 |
| R-HSA-9664407 | Parasite infection | 6.775240e-01 | 0.169 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.775240e-01 | 0.169 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.808874e-01 | 0.167 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.866659e-01 | 0.163 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.866659e-01 | 0.163 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.866659e-01 | 0.163 |
| R-HSA-597592 | Post-translational protein modification | 6.894200e-01 | 0.162 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.908064e-01 | 0.161 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.913045e-01 | 0.160 |
| R-HSA-8978934 | Metabolism of cofactors | 6.913045e-01 | 0.160 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.913045e-01 | 0.160 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.913045e-01 | 0.160 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.958747e-01 | 0.157 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.958747e-01 | 0.157 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.958747e-01 | 0.157 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.048140e-01 | 0.152 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.048140e-01 | 0.152 |
| R-HSA-166520 | Signaling by NTRKs | 7.067747e-01 | 0.151 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.091850e-01 | 0.149 |
| R-HSA-8852135 | Protein ubiquitination | 7.091850e-01 | 0.149 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.129677e-01 | 0.147 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.177346e-01 | 0.144 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.190511e-01 | 0.143 |
| R-HSA-74160 | Gene expression (Transcription) | 7.191905e-01 | 0.143 |
| R-HSA-69306 | DNA Replication | 7.220521e-01 | 0.141 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.260339e-01 | 0.139 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.285031e-01 | 0.138 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.300919e-01 | 0.137 |
| R-HSA-9833482 | PKR-mediated signaling | 7.300919e-01 | 0.137 |
| R-HSA-6806834 | Signaling by MET | 7.300919e-01 | 0.137 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.316229e-01 | 0.136 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.340901e-01 | 0.134 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.366554e-01 | 0.133 |
| R-HSA-877300 | Interferon gamma signaling | 7.394968e-01 | 0.131 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.505303e-01 | 0.125 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.568706e-01 | 0.121 |
| R-HSA-4839726 | Chromatin organization | 7.632585e-01 | 0.117 |
| R-HSA-202424 | Downstream TCR signaling | 7.709669e-01 | 0.113 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.709669e-01 | 0.113 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.743619e-01 | 0.111 |
| R-HSA-5688426 | Deubiquitination | 7.761187e-01 | 0.110 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.766029e-01 | 0.110 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.782057e-01 | 0.109 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.790687e-01 | 0.108 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.790687e-01 | 0.108 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.810024e-01 | 0.107 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.810024e-01 | 0.107 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.839292e-01 | 0.106 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.874482e-01 | 0.104 |
| R-HSA-1474290 | Collagen formation | 7.874482e-01 | 0.104 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.937050e-01 | 0.100 |
| R-HSA-190236 | Signaling by FGFR | 8.027480e-01 | 0.095 |
| R-HSA-3214847 | HATs acetylate histones | 8.056737e-01 | 0.094 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.113962e-01 | 0.091 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.131132e-01 | 0.090 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.141942e-01 | 0.089 |
| R-HSA-73894 | DNA Repair | 8.169990e-01 | 0.088 |
| R-HSA-1266738 | Developmental Biology | 8.230854e-01 | 0.085 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.295511e-01 | 0.081 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.326560e-01 | 0.080 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.326560e-01 | 0.080 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.371937e-01 | 0.077 |
| R-HSA-202403 | TCR signaling | 8.375870e-01 | 0.077 |
| R-HSA-388396 | GPCR downstream signalling | 8.380717e-01 | 0.077 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.423732e-01 | 0.074 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.423732e-01 | 0.074 |
| R-HSA-392499 | Metabolism of proteins | 8.429646e-01 | 0.074 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.478736e-01 | 0.072 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.537331e-01 | 0.069 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.559053e-01 | 0.068 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.559053e-01 | 0.068 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.599435e-01 | 0.066 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.662937e-01 | 0.062 |
| R-HSA-418990 | Adherens junctions interactions | 8.694341e-01 | 0.061 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.702372e-01 | 0.060 |
| R-HSA-9843745 | Adipogenesis | 8.882830e-01 | 0.051 |
| R-HSA-9717189 | Sensory perception of taste | 8.882830e-01 | 0.051 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.899440e-01 | 0.051 |
| R-HSA-1474244 | Extracellular matrix organization | 8.945258e-01 | 0.048 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.994058e-01 | 0.046 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.009020e-01 | 0.045 |
| R-HSA-6807070 | PTEN Regulation | 9.023761e-01 | 0.045 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.049895e-01 | 0.043 |
| R-HSA-372790 | Signaling by GPCR | 9.079304e-01 | 0.042 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.107731e-01 | 0.041 |
| R-HSA-421270 | Cell-cell junction organization | 9.118682e-01 | 0.040 |
| R-HSA-2187338 | Visual phototransduction | 9.146978e-01 | 0.039 |
| R-HSA-9758941 | Gastrulation | 9.172183e-01 | 0.038 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.196646e-01 | 0.036 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.208607e-01 | 0.036 |
| R-HSA-1989781 | PPARA activates gene expression | 9.243434e-01 | 0.034 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.265800e-01 | 0.033 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.283268e-01 | 0.032 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.325852e-01 | 0.030 |
| R-HSA-112316 | Neuronal System | 9.336265e-01 | 0.030 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.396630e-01 | 0.027 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.404966e-01 | 0.027 |
| R-HSA-418555 | G alpha (s) signalling events | 9.413836e-01 | 0.026 |
| R-HSA-418594 | G alpha (i) signalling events | 9.540577e-01 | 0.020 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.545981e-01 | 0.020 |
| R-HSA-212436 | Generic Transcription Pathway | 9.623307e-01 | 0.017 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.637689e-01 | 0.016 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.637689e-01 | 0.016 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.638828e-01 | 0.016 |
| R-HSA-9748784 | Drug ADME | 9.715256e-01 | 0.013 |
| R-HSA-8951664 | Neddylation | 9.727839e-01 | 0.012 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.747593e-01 | 0.011 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.762362e-01 | 0.010 |
| R-HSA-72312 | rRNA processing | 9.769421e-01 | 0.010 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.786305e-01 | 0.009 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.792522e-01 | 0.009 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.835178e-01 | 0.007 |
| R-HSA-416476 | G alpha (q) signalling events | 9.857746e-01 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.862753e-01 | 0.006 |
| R-HSA-72766 | Translation | 9.910025e-01 | 0.004 |
| R-HSA-1483257 | Phospholipid metabolism | 9.910986e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.992772e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.997290e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998714e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999019e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999373e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.838 | 0.110 | 2 | 0.862 |
DSTYK |
0.832 | 0.150 | 2 | 0.887 |
MARK4 |
0.829 | 0.323 | 4 | 0.829 |
CLK3 |
0.829 | 0.115 | 1 | 0.818 |
MARK3 |
0.824 | 0.380 | 4 | 0.870 |
NEK7 |
0.823 | 0.127 | -3 | 0.815 |
MARK2 |
0.823 | 0.374 | 4 | 0.847 |
NEK6 |
0.822 | 0.093 | -2 | 0.858 |
RAF1 |
0.821 | 0.047 | 1 | 0.875 |
AMPKA1 |
0.821 | 0.206 | -3 | 0.718 |
CAMK1B |
0.821 | 0.068 | -3 | 0.757 |
HUNK |
0.820 | 0.117 | 2 | 0.772 |
ULK2 |
0.819 | 0.030 | 2 | 0.750 |
NUAK2 |
0.818 | 0.099 | -3 | 0.715 |
QSK |
0.818 | 0.272 | 4 | 0.838 |
PIM3 |
0.817 | 0.009 | -3 | 0.706 |
TSSK1 |
0.817 | 0.182 | -3 | 0.728 |
BMPR1B |
0.816 | 0.180 | 1 | 0.796 |
CDC7 |
0.816 | -0.008 | 1 | 0.829 |
CAMK2G |
0.816 | 0.000 | 2 | 0.780 |
GCN2 |
0.816 | -0.023 | 2 | 0.765 |
PLK1 |
0.816 | 0.129 | -2 | 0.857 |
TSSK2 |
0.815 | 0.148 | -5 | 0.734 |
PKN3 |
0.815 | 0.013 | -3 | 0.714 |
PRPK |
0.815 | -0.130 | -1 | 0.805 |
BMPR2 |
0.815 | -0.016 | -2 | 0.868 |
AMPKA2 |
0.815 | 0.169 | -3 | 0.686 |
ATR |
0.815 | 0.027 | 1 | 0.858 |
PKCD |
0.814 | 0.064 | 2 | 0.778 |
PIM1 |
0.814 | 0.050 | -3 | 0.655 |
MST4 |
0.814 | 0.036 | 2 | 0.825 |
TGFBR2 |
0.814 | 0.069 | -2 | 0.863 |
FAM20C |
0.813 | 0.116 | 2 | 0.661 |
NLK |
0.813 | 0.006 | 1 | 0.839 |
MARK1 |
0.812 | 0.299 | 4 | 0.837 |
ULK1 |
0.812 | 0.007 | -3 | 0.779 |
NIK |
0.812 | 0.022 | -3 | 0.772 |
RSK2 |
0.812 | 0.041 | -3 | 0.657 |
MOS |
0.812 | -0.053 | 1 | 0.855 |
TBK1 |
0.812 | -0.015 | 1 | 0.777 |
SIK |
0.811 | 0.198 | -3 | 0.646 |
GRK6 |
0.811 | 0.060 | 1 | 0.852 |
CDKL1 |
0.811 | -0.003 | -3 | 0.711 |
PLK3 |
0.811 | 0.135 | 2 | 0.738 |
SRPK1 |
0.811 | 0.043 | -3 | 0.649 |
WNK1 |
0.811 | 0.043 | -2 | 0.810 |
PKN2 |
0.811 | 0.020 | -3 | 0.724 |
MLK1 |
0.811 | -0.027 | 2 | 0.804 |
IKKB |
0.810 | -0.048 | -2 | 0.700 |
MTOR |
0.810 | -0.094 | 1 | 0.803 |
NUAK1 |
0.810 | 0.114 | -3 | 0.670 |
TGFBR1 |
0.810 | 0.166 | -2 | 0.869 |
PDHK4 |
0.809 | -0.156 | 1 | 0.874 |
CAMLCK |
0.809 | 0.028 | -2 | 0.843 |
CHAK2 |
0.808 | 0.014 | -1 | 0.868 |
NEK9 |
0.808 | 0.010 | 2 | 0.810 |
ATM |
0.808 | 0.048 | 1 | 0.802 |
IKKE |
0.808 | -0.031 | 1 | 0.777 |
NDR1 |
0.808 | 0.004 | -3 | 0.702 |
QIK |
0.807 | 0.153 | -3 | 0.725 |
SKMLCK |
0.807 | 0.014 | -2 | 0.839 |
ALK4 |
0.806 | 0.127 | -2 | 0.879 |
PRKD2 |
0.806 | 0.023 | -3 | 0.630 |
NDR2 |
0.806 | -0.032 | -3 | 0.694 |
IKKA |
0.805 | 0.014 | -2 | 0.694 |
P70S6KB |
0.805 | 0.013 | -3 | 0.686 |
SRPK2 |
0.805 | 0.043 | -3 | 0.586 |
DAPK2 |
0.805 | -0.005 | -3 | 0.762 |
SSTK |
0.804 | 0.235 | 4 | 0.778 |
CAMK2B |
0.804 | 0.035 | 2 | 0.775 |
PKACG |
0.804 | 0.042 | -2 | 0.766 |
NIM1 |
0.804 | 0.054 | 3 | 0.705 |
RSK3 |
0.804 | 0.013 | -3 | 0.665 |
AURC |
0.804 | 0.089 | -2 | 0.709 |
ANKRD3 |
0.804 | -0.018 | 1 | 0.895 |
PDHK1 |
0.804 | -0.128 | 1 | 0.876 |
PKCB |
0.804 | 0.035 | 2 | 0.747 |
RIPK3 |
0.804 | -0.060 | 3 | 0.629 |
ALK2 |
0.803 | 0.141 | -2 | 0.860 |
PKR |
0.803 | 0.034 | 1 | 0.888 |
CLK1 |
0.803 | 0.079 | -3 | 0.633 |
CLK4 |
0.803 | 0.067 | -3 | 0.655 |
BMPR1A |
0.803 | 0.164 | 1 | 0.779 |
PRKD1 |
0.803 | -0.025 | -3 | 0.693 |
P90RSK |
0.803 | -0.004 | -3 | 0.665 |
BRSK1 |
0.803 | 0.120 | -3 | 0.671 |
HIPK4 |
0.803 | 0.033 | 1 | 0.840 |
NEK2 |
0.802 | 0.065 | 2 | 0.783 |
GRK5 |
0.802 | -0.097 | -3 | 0.767 |
LATS1 |
0.802 | 0.017 | -3 | 0.709 |
WNK3 |
0.801 | -0.058 | 1 | 0.857 |
GRK7 |
0.801 | 0.091 | 1 | 0.764 |
ACVR2A |
0.801 | 0.106 | -2 | 0.846 |
CLK2 |
0.801 | 0.085 | -3 | 0.630 |
LATS2 |
0.801 | -0.015 | -5 | 0.694 |
DLK |
0.800 | -0.097 | 1 | 0.872 |
ICK |
0.800 | -0.014 | -3 | 0.727 |
GRK1 |
0.800 | -0.007 | -2 | 0.712 |
RSK4 |
0.799 | 0.040 | -3 | 0.617 |
PKACB |
0.799 | 0.069 | -2 | 0.730 |
CAMK2D |
0.799 | -0.049 | -3 | 0.725 |
IRE2 |
0.799 | 0.004 | 2 | 0.716 |
CDKL5 |
0.799 | -0.023 | -3 | 0.697 |
PKCH |
0.798 | 0.019 | 2 | 0.716 |
ACVR2B |
0.798 | 0.092 | -2 | 0.850 |
MAPKAPK3 |
0.798 | -0.014 | -3 | 0.648 |
CAMK1G |
0.798 | 0.077 | -3 | 0.662 |
AURB |
0.798 | 0.075 | -2 | 0.709 |
SRPK3 |
0.798 | 0.013 | -3 | 0.645 |
CAMK2A |
0.798 | 0.007 | 2 | 0.779 |
MELK |
0.797 | 0.047 | -3 | 0.678 |
PKCG |
0.797 | 0.007 | 2 | 0.731 |
ERK5 |
0.797 | -0.066 | 1 | 0.771 |
PRKD3 |
0.797 | 0.011 | -3 | 0.638 |
MSK2 |
0.797 | -0.000 | -3 | 0.641 |
IRE1 |
0.797 | -0.037 | 1 | 0.849 |
TLK2 |
0.797 | 0.033 | 1 | 0.866 |
PAK6 |
0.797 | 0.098 | -2 | 0.707 |
MLK4 |
0.797 | -0.025 | 2 | 0.722 |
PAK1 |
0.796 | 0.021 | -2 | 0.776 |
PRKX |
0.796 | 0.081 | -3 | 0.538 |
MLK3 |
0.796 | -0.038 | 2 | 0.746 |
BCKDK |
0.796 | -0.104 | -1 | 0.760 |
MNK2 |
0.796 | 0.031 | -2 | 0.810 |
BRSK2 |
0.796 | 0.102 | -3 | 0.686 |
MYLK4 |
0.796 | 0.044 | -2 | 0.788 |
BRAF |
0.795 | 0.044 | -4 | 0.786 |
GRK4 |
0.795 | -0.063 | -2 | 0.790 |
PKCA |
0.795 | -0.000 | 2 | 0.726 |
CHAK1 |
0.795 | -0.012 | 2 | 0.733 |
MSK1 |
0.795 | 0.028 | -3 | 0.645 |
MAPKAPK2 |
0.795 | 0.004 | -3 | 0.601 |
TLK1 |
0.794 | 0.047 | -2 | 0.858 |
PINK1 |
0.794 | 0.013 | 1 | 0.854 |
MLK2 |
0.793 | -0.123 | 2 | 0.814 |
CAMK4 |
0.793 | -0.042 | -3 | 0.693 |
TTBK2 |
0.793 | -0.082 | 2 | 0.675 |
DNAPK |
0.793 | 0.021 | 1 | 0.754 |
PKCZ |
0.793 | -0.009 | 2 | 0.761 |
SGK3 |
0.793 | 0.038 | -3 | 0.642 |
MEK1 |
0.793 | -0.071 | 2 | 0.810 |
PKG2 |
0.792 | 0.052 | -2 | 0.720 |
RIPK1 |
0.792 | -0.127 | 1 | 0.870 |
PAK3 |
0.792 | -0.006 | -2 | 0.774 |
AKT2 |
0.791 | 0.027 | -3 | 0.584 |
AURA |
0.791 | 0.047 | -2 | 0.695 |
YSK4 |
0.791 | -0.084 | 1 | 0.815 |
CDK5 |
0.791 | 0.015 | 1 | 0.678 |
NEK5 |
0.790 | 0.039 | 1 | 0.862 |
CDK2 |
0.790 | 0.030 | 1 | 0.705 |
CDK1 |
0.789 | 0.019 | 1 | 0.620 |
MNK1 |
0.789 | 0.016 | -2 | 0.820 |
HRI |
0.789 | -0.032 | -2 | 0.848 |
CHK1 |
0.789 | -0.015 | -3 | 0.696 |
MASTL |
0.789 | -0.240 | -2 | 0.760 |
CDK8 |
0.789 | -0.021 | 1 | 0.667 |
KIS |
0.788 | -0.020 | 1 | 0.686 |
DCAMKL1 |
0.788 | 0.012 | -3 | 0.647 |
MEKK1 |
0.788 | -0.047 | 1 | 0.860 |
CK2A2 |
0.787 | 0.160 | 1 | 0.677 |
PIM2 |
0.787 | 0.005 | -3 | 0.638 |
VRK2 |
0.787 | -0.183 | 1 | 0.898 |
PERK |
0.787 | -0.029 | -2 | 0.827 |
PHKG1 |
0.787 | -0.041 | -3 | 0.690 |
PAK2 |
0.786 | -0.005 | -2 | 0.759 |
DYRK2 |
0.786 | -0.009 | 1 | 0.725 |
PKCT |
0.786 | 0.007 | 2 | 0.726 |
PLK2 |
0.786 | 0.088 | -3 | 0.804 |
CAMK1D |
0.786 | 0.045 | -3 | 0.561 |
GRK2 |
0.786 | -0.020 | -2 | 0.701 |
PLK4 |
0.785 | -0.025 | 2 | 0.576 |
DRAK1 |
0.785 | -0.037 | 1 | 0.793 |
JNK2 |
0.785 | 0.018 | 1 | 0.610 |
SMMLCK |
0.785 | 0.008 | -3 | 0.718 |
PKACA |
0.785 | 0.056 | -2 | 0.688 |
ZAK |
0.785 | -0.071 | 1 | 0.844 |
GSK3A |
0.785 | -0.014 | 4 | 0.338 |
SMG1 |
0.784 | -0.043 | 1 | 0.813 |
NEK8 |
0.784 | 0.010 | 2 | 0.786 |
MEKK3 |
0.784 | -0.099 | 1 | 0.848 |
MEKK2 |
0.784 | -0.060 | 2 | 0.788 |
JNK3 |
0.783 | 0.004 | 1 | 0.640 |
MST3 |
0.783 | -0.026 | 2 | 0.820 |
SNRK |
0.782 | -0.046 | 2 | 0.636 |
TAO3 |
0.781 | -0.050 | 1 | 0.833 |
WNK4 |
0.781 | -0.051 | -2 | 0.782 |
IRAK4 |
0.781 | -0.042 | 1 | 0.852 |
DCAMKL2 |
0.781 | -0.005 | -3 | 0.679 |
MEK5 |
0.781 | -0.164 | 2 | 0.800 |
GSK3B |
0.781 | -0.048 | 4 | 0.332 |
AKT1 |
0.781 | 0.029 | -3 | 0.589 |
P38A |
0.780 | -0.011 | 1 | 0.687 |
HIPK1 |
0.780 | 0.010 | 1 | 0.738 |
PKCI |
0.780 | 0.011 | 2 | 0.721 |
CAMKK1 |
0.780 | -0.044 | -2 | 0.693 |
CDK19 |
0.779 | -0.028 | 1 | 0.624 |
GAK |
0.779 | 0.011 | 1 | 0.820 |
P38G |
0.779 | 0.009 | 1 | 0.529 |
PHKG2 |
0.779 | -0.017 | -3 | 0.677 |
CDK3 |
0.779 | 0.039 | 1 | 0.547 |
MST2 |
0.779 | 0.002 | 1 | 0.844 |
PKCE |
0.779 | 0.028 | 2 | 0.713 |
DAPK3 |
0.778 | 0.027 | -3 | 0.673 |
ERK2 |
0.778 | -0.019 | 1 | 0.652 |
EEF2K |
0.777 | 0.010 | 3 | 0.796 |
PASK |
0.777 | -0.052 | -3 | 0.729 |
CDK13 |
0.776 | -0.041 | 1 | 0.632 |
CDK7 |
0.776 | -0.048 | 1 | 0.663 |
CAMK1A |
0.776 | 0.058 | -3 | 0.547 |
MAPKAPK5 |
0.776 | -0.089 | -3 | 0.645 |
TNIK |
0.776 | 0.008 | 3 | 0.789 |
ERK1 |
0.776 | -0.010 | 1 | 0.602 |
NEK4 |
0.776 | 0.012 | 1 | 0.842 |
CDK18 |
0.775 | -0.026 | 1 | 0.584 |
P38B |
0.775 | -0.003 | 1 | 0.606 |
CK2A1 |
0.775 | 0.123 | 1 | 0.658 |
PRP4 |
0.775 | -0.050 | -3 | 0.659 |
HIPK2 |
0.775 | 0.001 | 1 | 0.630 |
MRCKB |
0.774 | 0.053 | -3 | 0.624 |
TAO2 |
0.774 | -0.064 | 2 | 0.827 |
P70S6K |
0.774 | -0.031 | -3 | 0.620 |
DYRK1A |
0.773 | -0.025 | 1 | 0.743 |
PAK5 |
0.773 | 0.044 | -2 | 0.651 |
TAK1 |
0.773 | -0.013 | 1 | 0.881 |
DYRK3 |
0.773 | 0.012 | 1 | 0.758 |
CDK16 |
0.773 | 0.008 | 1 | 0.545 |
CAMKK2 |
0.772 | -0.062 | -2 | 0.691 |
MRCKA |
0.772 | 0.042 | -3 | 0.633 |
LKB1 |
0.772 | -0.046 | -3 | 0.748 |
MST1 |
0.772 | 0.004 | 1 | 0.835 |
NEK1 |
0.772 | 0.037 | 1 | 0.843 |
MINK |
0.772 | -0.037 | 1 | 0.846 |
SGK1 |
0.771 | 0.025 | -3 | 0.512 |
NEK11 |
0.771 | -0.122 | 1 | 0.839 |
HGK |
0.771 | -0.034 | 3 | 0.781 |
GRK3 |
0.771 | -0.026 | -2 | 0.662 |
GCK |
0.771 | -0.049 | 1 | 0.846 |
ROCK2 |
0.771 | 0.050 | -3 | 0.654 |
DYRK1B |
0.770 | -0.005 | 1 | 0.648 |
CDK17 |
0.770 | -0.026 | 1 | 0.533 |
IRAK1 |
0.770 | -0.125 | -1 | 0.718 |
PAK4 |
0.770 | 0.054 | -2 | 0.672 |
DAPK1 |
0.770 | 0.006 | -3 | 0.665 |
CDK12 |
0.770 | -0.038 | 1 | 0.609 |
CDK9 |
0.770 | -0.049 | 1 | 0.641 |
AKT3 |
0.769 | 0.025 | -3 | 0.520 |
DYRK4 |
0.768 | -0.008 | 1 | 0.630 |
CK1E |
0.768 | -0.074 | -3 | 0.472 |
LOK |
0.768 | -0.026 | -2 | 0.738 |
PDK1 |
0.767 | -0.068 | 1 | 0.832 |
HIPK3 |
0.767 | -0.037 | 1 | 0.732 |
MEKK6 |
0.767 | -0.083 | 1 | 0.828 |
DMPK1 |
0.767 | 0.070 | -3 | 0.634 |
CDK14 |
0.767 | -0.027 | 1 | 0.634 |
CDK10 |
0.766 | 0.003 | 1 | 0.620 |
MPSK1 |
0.766 | -0.065 | 1 | 0.810 |
CHK2 |
0.766 | -0.020 | -3 | 0.532 |
PKN1 |
0.766 | -0.025 | -3 | 0.623 |
P38D |
0.765 | -0.004 | 1 | 0.546 |
STK33 |
0.765 | -0.049 | 2 | 0.571 |
KHS2 |
0.765 | -0.002 | 1 | 0.845 |
ERK7 |
0.765 | -0.019 | 2 | 0.524 |
TTK |
0.764 | 0.025 | -2 | 0.863 |
HPK1 |
0.764 | -0.051 | 1 | 0.833 |
TTBK1 |
0.764 | -0.106 | 2 | 0.583 |
MAP3K15 |
0.764 | -0.097 | 1 | 0.818 |
LRRK2 |
0.764 | -0.102 | 2 | 0.804 |
KHS1 |
0.763 | -0.022 | 1 | 0.831 |
ROCK1 |
0.762 | 0.053 | -3 | 0.633 |
VRK1 |
0.762 | -0.111 | 2 | 0.797 |
YSK1 |
0.762 | -0.056 | 2 | 0.787 |
SLK |
0.761 | -0.068 | -2 | 0.675 |
OSR1 |
0.760 | -0.030 | 2 | 0.774 |
CK1G1 |
0.760 | -0.083 | -3 | 0.470 |
CDK6 |
0.760 | -0.007 | 1 | 0.610 |
CK1A2 |
0.759 | -0.069 | -3 | 0.422 |
JNK1 |
0.759 | -0.022 | 1 | 0.586 |
MEK2 |
0.758 | -0.109 | 2 | 0.779 |
CK1D |
0.758 | -0.080 | -3 | 0.420 |
HASPIN |
0.758 | 0.066 | -1 | 0.793 |
BUB1 |
0.757 | 0.006 | -5 | 0.686 |
PKG1 |
0.757 | 0.034 | -2 | 0.648 |
NEK3 |
0.757 | -0.059 | 1 | 0.807 |
CDK4 |
0.755 | -0.025 | 1 | 0.596 |
MOK |
0.754 | -0.006 | 1 | 0.748 |
MAK |
0.753 | -0.010 | -2 | 0.674 |
RIPK2 |
0.752 | -0.153 | 1 | 0.801 |
CRIK |
0.751 | 0.010 | -3 | 0.582 |
SBK |
0.751 | -0.024 | -3 | 0.473 |
MYO3B |
0.751 | -0.039 | 2 | 0.798 |
MYO3A |
0.750 | -0.044 | 1 | 0.849 |
PDHK3_TYR |
0.750 | 0.085 | 4 | 0.661 |
PBK |
0.748 | -0.067 | 1 | 0.725 |
PDHK4_TYR |
0.743 | 0.046 | 2 | 0.848 |
BIKE |
0.743 | -0.031 | 1 | 0.675 |
TAO1 |
0.743 | -0.090 | 1 | 0.779 |
ASK1 |
0.743 | -0.101 | 1 | 0.802 |
ALPHAK3 |
0.741 | -0.082 | -1 | 0.747 |
TESK1_TYR |
0.741 | -0.055 | 3 | 0.803 |
MAP2K6_TYR |
0.740 | -0.039 | -1 | 0.837 |
BMPR2_TYR |
0.739 | -0.028 | -1 | 0.815 |
MAP2K7_TYR |
0.739 | -0.055 | 2 | 0.823 |
STLK3 |
0.738 | -0.087 | 1 | 0.809 |
PDHK1_TYR |
0.737 | -0.039 | -1 | 0.844 |
PINK1_TYR |
0.736 | -0.092 | 1 | 0.852 |
MAP2K4_TYR |
0.736 | -0.125 | -1 | 0.830 |
LIMK2_TYR |
0.735 | -0.020 | -3 | 0.776 |
EPHA6 |
0.735 | -0.007 | -1 | 0.812 |
YANK3 |
0.734 | -0.087 | 2 | 0.371 |
RET |
0.733 | -0.069 | 1 | 0.839 |
PKMYT1_TYR |
0.732 | -0.146 | 3 | 0.749 |
LIMK1_TYR |
0.730 | -0.088 | 2 | 0.815 |
DDR1 |
0.729 | -0.082 | 4 | 0.612 |
TYK2 |
0.726 | -0.122 | 1 | 0.834 |
AAK1 |
0.726 | -0.010 | 1 | 0.561 |
ROS1 |
0.725 | -0.108 | 3 | 0.664 |
TYRO3 |
0.725 | -0.123 | 3 | 0.695 |
EPHB4 |
0.724 | -0.081 | -1 | 0.790 |
TNNI3K_TYR |
0.724 | 0.014 | 1 | 0.867 |
TXK |
0.724 | 0.005 | 1 | 0.816 |
MST1R |
0.723 | -0.141 | 3 | 0.686 |
INSRR |
0.723 | -0.077 | 3 | 0.650 |
CSF1R |
0.722 | -0.107 | 3 | 0.666 |
JAK3 |
0.722 | -0.096 | 1 | 0.815 |
JAK2 |
0.721 | -0.140 | 1 | 0.832 |
ABL2 |
0.720 | -0.077 | -1 | 0.757 |
FER |
0.720 | -0.106 | 1 | 0.842 |
EPHA4 |
0.720 | -0.056 | 2 | 0.738 |
YES1 |
0.719 | -0.079 | -1 | 0.754 |
NEK10_TYR |
0.719 | -0.051 | 1 | 0.711 |
FLT3 |
0.718 | -0.097 | 3 | 0.680 |
PDGFRB |
0.717 | -0.118 | 3 | 0.688 |
FGR |
0.717 | -0.129 | 1 | 0.829 |
CK1A |
0.717 | -0.103 | -3 | 0.338 |
EPHB1 |
0.717 | -0.077 | 1 | 0.842 |
FGFR2 |
0.716 | -0.114 | 3 | 0.688 |
KDR |
0.716 | -0.092 | 3 | 0.632 |
TNK1 |
0.716 | -0.067 | 3 | 0.667 |
ITK |
0.716 | -0.081 | -1 | 0.705 |
TEC |
0.714 | -0.049 | -1 | 0.661 |
EPHB2 |
0.714 | -0.058 | -1 | 0.761 |
KIT |
0.714 | -0.126 | 3 | 0.672 |
BLK |
0.714 | -0.023 | -1 | 0.745 |
TEK |
0.713 | -0.110 | 3 | 0.632 |
SRMS |
0.713 | -0.107 | 1 | 0.837 |
ABL1 |
0.713 | -0.104 | -1 | 0.743 |
EPHB3 |
0.713 | -0.100 | -1 | 0.767 |
DDR2 |
0.712 | -0.051 | 3 | 0.630 |
TNK2 |
0.712 | -0.118 | 3 | 0.620 |
FGFR1 |
0.712 | -0.111 | 3 | 0.657 |
CK1G3 |
0.712 | -0.085 | -3 | 0.296 |
LCK |
0.711 | -0.083 | -1 | 0.721 |
WEE1_TYR |
0.711 | -0.078 | -1 | 0.688 |
BMX |
0.711 | -0.067 | -1 | 0.643 |
HCK |
0.711 | -0.126 | -1 | 0.724 |
JAK1 |
0.710 | -0.095 | 1 | 0.789 |
FLT1 |
0.709 | -0.092 | -1 | 0.791 |
MET |
0.708 | -0.133 | 3 | 0.654 |
EPHA7 |
0.707 | -0.091 | 2 | 0.738 |
AXL |
0.707 | -0.153 | 3 | 0.655 |
FGFR3 |
0.706 | -0.112 | 3 | 0.663 |
MERTK |
0.706 | -0.125 | 3 | 0.648 |
PDGFRA |
0.705 | -0.195 | 3 | 0.681 |
BTK |
0.705 | -0.155 | -1 | 0.670 |
ALK |
0.705 | -0.142 | 3 | 0.609 |
ERBB2 |
0.704 | -0.134 | 1 | 0.780 |
MATK |
0.704 | -0.090 | -1 | 0.708 |
YANK2 |
0.704 | -0.106 | 2 | 0.392 |
PTK6 |
0.704 | -0.154 | -1 | 0.640 |
INSR |
0.704 | -0.129 | 3 | 0.625 |
FLT4 |
0.703 | -0.133 | 3 | 0.629 |
LTK |
0.703 | -0.140 | 3 | 0.621 |
EPHA3 |
0.702 | -0.136 | 2 | 0.710 |
NTRK1 |
0.702 | -0.180 | -1 | 0.763 |
FRK |
0.702 | -0.104 | -1 | 0.763 |
EPHA5 |
0.701 | -0.083 | 2 | 0.731 |
FYN |
0.701 | -0.069 | -1 | 0.687 |
NTRK2 |
0.700 | -0.161 | 3 | 0.627 |
EGFR |
0.700 | -0.066 | 1 | 0.685 |
EPHA1 |
0.699 | -0.152 | 3 | 0.630 |
LYN |
0.697 | -0.115 | 3 | 0.597 |
PTK2 |
0.697 | -0.036 | -1 | 0.722 |
EPHA8 |
0.696 | -0.102 | -1 | 0.742 |
NTRK3 |
0.696 | -0.148 | -1 | 0.716 |
FGFR4 |
0.694 | -0.096 | -1 | 0.721 |
PTK2B |
0.693 | -0.106 | -1 | 0.694 |
SYK |
0.693 | -0.052 | -1 | 0.714 |
CSK |
0.693 | -0.139 | 2 | 0.739 |
CK1G2 |
0.690 | -0.098 | -3 | 0.389 |
IGF1R |
0.689 | -0.126 | 3 | 0.573 |
SRC |
0.689 | -0.126 | -1 | 0.693 |
EPHA2 |
0.687 | -0.103 | -1 | 0.716 |
ERBB4 |
0.684 | -0.086 | 1 | 0.690 |
MUSK |
0.681 | -0.140 | 1 | 0.661 |
FES |
0.668 | -0.154 | -1 | 0.612 |
ZAP70 |
0.665 | -0.106 | -1 | 0.641 |