Motif 640 (n=73)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H3BQL2 | GOLGA8T | S458 | ochoa | Golgin subfamily A member 8T | None |
| I6L899 | GOLGA8R | S457 | ochoa | Golgin subfamily A member 8R | None |
| M0QYT0 | None | S103 | ochoa | RRM domain-containing protein | None |
| O00515 | LAD1 | S365 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O15381 | NVL | S149 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O75122 | CLASP2 | S952 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O94880 | PHF14 | S530 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94915 | FRYL | S1484 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| P08567 | PLEK | S222 | ochoa | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P0DMU7 | CT45A6 | S115 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S115 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMV0 | CT45A7 | S115 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P10275 | AR | S220 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P13804 | ETFA | S189 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P14866 | HNRNPL | S486 | ochoa | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| P15924 | DSP | S2585 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P30260 | CDC27 | S435 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P38919 | EIF4A3 | S62 | ochoa | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P40121 | CAPG | S129 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P41231 | P2RY2 | S356 | ochoa|psp | P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. |
| P47712 | PLA2G4A | S724 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P49321 | NASP | S705 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P60709 | ACTB | T201 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P60842 | EIF4A1 | S56 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P63261 | ACTG1 | T201 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| Q01484 | ANK2 | S2320 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02952 | AKAP12 | S1226 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S3216 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03188 | CENPC | S557 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05209 | PTPN12 | S551 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05639 | EEF1A2 | S163 | ochoa | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q09666 | AHNAK | S3326 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12955 | ANK3 | S4349 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13033 | STRN3 | S335 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q14008 | CKAP5 | S2005 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14240 | EIF4A2 | S57 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14789 | GOLGB1 | S1571 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14807 | KIF22 | S543 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q2M1K9 | ZNF423 | S1054 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q3B726 | POLR1F | S60 | ochoa | DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| Q3V6T2 | CCDC88A | S1653 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5HYN5 | CT45A1 | S115 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5T0B9 | ZNF362 | S160 | ochoa | Zinc finger protein 362 | May be involved in transcriptional regulation. |
| Q5TB30 | DEPDC1 | S110 | ochoa|psp | DEP domain-containing protein 1A | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
| Q66K74 | MAP1S | S547 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6VMQ6 | ATF7IP | S403 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q7Z460 | CLASP1 | S1193 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4S6 | KIF21A | S530 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6B0 | CCDC91 | S79 | ochoa | Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) | Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}. |
| Q7Z6E9 | RBBP6 | S1277 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q8ND76 | CCNY | S21 | ochoa | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NHU0 | CT45A3 | S115 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TF72 | SHROOM3 | S1656 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q96D71 | REPS1 | S274 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96PY6 | NEK1 | S664 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96T58 | SPEN | S847 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T68 | SETDB2 | S318 | ochoa | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}. |
| Q99081 | TCF12 | S559 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q9BRJ6 | C7orf50 | S59 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9GZV1 | ANKRD2 | S99 | ochoa|psp | Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp) | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}. |
| Q9HD67 | MYO10 | S1143 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9P266 | JCAD | S543 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UIS9 | MBD1 | S465 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UKA4 | AKAP11 | S1113 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9Y485 | DMXL1 | S859 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y5Y4 | PTGDR2 | S339 | ochoa | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
| Q9Y608 | LRRFIP2 | S340 | ochoa | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| O15075 | DCLK1 | S172 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| Q99584 | S100A13 | S34 | Sugiyama | Protein S100-A13 (S100 calcium-binding protein A13) | Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250|UniProtKB:P97352, ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}. |
| Q9NWM8 | FKBP14 | S140 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase) | PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. {ECO:0000269|PubMed:24821723}. |
| Q16513 | PKN2 | S37 | Sugiyama | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| O75179 | ANKRD17 | S1159 | Sugiyama | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| Q8IWZ3 | ANKHD1 | S1131 | Sugiyama | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.000022 | 4.652 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.000071 | 4.151 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.000216 | 3.665 |
| R-HSA-429947 | Deadenylation of mRNA | 0.000443 | 3.353 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001174 | 2.930 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001174 | 2.930 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.001122 | 2.950 |
| R-HSA-196025 | Formation of annular gap junctions | 0.001354 | 2.868 |
| R-HSA-190873 | Gap junction degradation | 0.001606 | 2.794 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.001705 | 2.768 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.001705 | 2.768 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.001965 | 2.707 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.002923 | 2.534 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003768 | 2.424 |
| R-HSA-373760 | L1CAM interactions | 0.003770 | 2.424 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.004343 | 2.362 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.004305 | 2.366 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.003939 | 2.405 |
| R-HSA-199991 | Membrane Trafficking | 0.005051 | 2.297 |
| R-HSA-68882 | Mitotic Anaphase | 0.005892 | 2.230 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.005995 | 2.222 |
| R-HSA-422475 | Axon guidance | 0.006134 | 2.212 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.007813 | 2.107 |
| R-HSA-9675108 | Nervous system development | 0.008829 | 2.054 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.011435 | 1.942 |
| R-HSA-68886 | M Phase | 0.013622 | 1.866 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.013411 | 1.873 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.015418 | 1.812 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.014123 | 1.850 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.014341 | 1.843 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.014341 | 1.843 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.018745 | 1.727 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.019543 | 1.709 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.051905 | 1.285 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.061052 | 1.214 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.070112 | 1.154 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.070112 | 1.154 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.083541 | 1.078 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.092386 | 1.034 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.092386 | 1.034 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.101148 | 0.995 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.105497 | 0.977 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.109826 | 0.959 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.114134 | 0.943 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.118421 | 0.927 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.122688 | 0.911 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.131161 | 0.882 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.035641 | 1.448 |
| R-HSA-72649 | Translation initiation complex formation | 0.036706 | 1.435 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.038872 | 1.410 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.147865 | 0.830 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.046823 | 1.330 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.046823 | 1.330 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.050398 | 1.298 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.059105 | 1.228 |
| R-HSA-380287 | Centrosome maturation | 0.061682 | 1.210 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.080730 | 1.093 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.143719 | 0.842 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.083584 | 1.078 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.087974 | 1.056 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.041086 | 1.386 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.049196 | 1.308 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.096778 | 1.014 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.147865 | 0.830 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.101148 | 0.995 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.023865 | 1.622 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.118421 | 0.927 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.143719 | 0.842 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.023865 | 1.622 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.028539 | 1.545 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.028539 | 1.545 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.028539 | 1.545 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.043713 | 1.359 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.104380 | 0.981 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.075116 | 1.124 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.079086 | 1.102 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.096778 | 1.014 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.135367 | 0.868 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.073734 | 1.132 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.028539 | 1.545 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.131266 | 0.882 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.056567 | 1.247 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.131266 | 0.882 |
| R-HSA-73886 | Chromosome Maintenance | 0.139455 | 0.856 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.061052 | 1.214 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.083541 | 1.078 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.096778 | 1.014 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.160184 | 0.795 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.160184 | 0.795 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.073734 | 1.132 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.115257 | 0.938 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.115257 | 0.938 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.143719 | 0.842 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.139553 | 0.855 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.139553 | 0.855 |
| R-HSA-69239 | Synthesis of DNA | 0.113685 | 0.944 |
| R-HSA-69109 | Leading Strand Synthesis | 0.074610 | 1.127 |
| R-HSA-69091 | Polymerase switching | 0.074610 | 1.127 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.139553 | 0.855 |
| R-HSA-9839394 | TGFBR3 expression | 0.139553 | 0.855 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.073734 | 1.132 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.041736 | 1.379 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.110560 | 0.956 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.156097 | 0.807 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.041087 | 1.386 |
| R-HSA-9664407 | Parasite infection | 0.041087 | 1.386 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.041087 | 1.386 |
| R-HSA-437239 | Recycling pathway of L1 | 0.029515 | 1.530 |
| R-HSA-983189 | Kinesins | 0.043347 | 1.363 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.083541 | 1.078 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.087974 | 1.056 |
| R-HSA-190828 | Gap junction trafficking | 0.026628 | 1.575 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.068288 | 1.166 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.039973 | 1.398 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.095302 | 1.021 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.023753 | 1.624 |
| R-HSA-1640170 | Cell Cycle | 0.063212 | 1.199 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.085402 | 1.069 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.083541 | 1.078 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.114134 | 0.943 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.031505 | 1.502 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.139553 | 0.855 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.035484 | 1.450 |
| R-HSA-9659379 | Sensory processing of sound | 0.066948 | 1.174 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.046421 | 1.333 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.135367 | 0.868 |
| R-HSA-525793 | Myogenesis | 0.143719 | 0.842 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.052835 | 1.277 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.067611 | 1.170 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.059105 | 1.228 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.029216 | 1.534 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.074610 | 1.127 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.038872 | 1.410 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.107458 | 0.969 |
| R-HSA-4839726 | Chromatin organization | 0.041961 | 1.377 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.065593 | 1.183 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.101148 | 0.995 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.105497 | 0.977 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.029515 | 1.530 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.051905 | 1.285 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.101148 | 0.995 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.118421 | 0.927 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.092443 | 1.034 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.124800 | 0.904 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.068437 | 1.165 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.083541 | 1.078 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.151991 | 0.818 |
| R-HSA-417957 | P2Y receptors | 0.083541 | 1.078 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.160184 | 0.795 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.035185 | 1.454 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.105497 | 0.977 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.114134 | 0.943 |
| R-HSA-418990 | Adherens junctions interactions | 0.028715 | 1.542 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.090557 | 1.043 |
| R-HSA-446728 | Cell junction organization | 0.057023 | 1.244 |
| R-HSA-421270 | Cell-cell junction organization | 0.042917 | 1.367 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.061682 | 1.210 |
| R-HSA-5358508 | Mismatch Repair | 0.105497 | 0.977 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.020762 | 1.683 |
| R-HSA-1500931 | Cell-Cell communication | 0.080599 | 1.094 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.093392 | 1.030 |
| R-HSA-1266738 | Developmental Biology | 0.089755 | 1.047 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.026628 | 1.575 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.087924 | 1.056 |
| R-HSA-162582 | Signal Transduction | 0.089098 | 1.050 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.077907 | 1.108 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.086470 | 1.063 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.160184 | 0.795 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.051357 | 1.289 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.129642 | 0.887 |
| R-HSA-194138 | Signaling by VEGF | 0.147753 | 0.830 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.164251 | 0.784 |
| R-HSA-182971 | EGFR downregulation | 0.164251 | 0.784 |
| R-HSA-69190 | DNA strand elongation | 0.168299 | 0.774 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.168299 | 0.774 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.168299 | 0.774 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.174930 | 0.757 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.176337 | 0.754 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.176337 | 0.754 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.176337 | 0.754 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.179403 | 0.746 |
| R-HSA-9658195 | Leishmania infection | 0.179403 | 0.746 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.180327 | 0.744 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.180327 | 0.744 |
| R-HSA-392518 | Signal amplification | 0.180327 | 0.744 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.180607 | 0.743 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.184298 | 0.734 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.184298 | 0.734 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.188250 | 0.725 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.188250 | 0.725 |
| R-HSA-69242 | S Phase | 0.192303 | 0.716 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.199317 | 0.700 |
| R-HSA-69306 | DNA Replication | 0.201075 | 0.697 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.203870 | 0.691 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.203870 | 0.691 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.207728 | 0.683 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.207728 | 0.683 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.207728 | 0.683 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.207728 | 0.683 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.211568 | 0.675 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.215389 | 0.667 |
| R-HSA-111996 | Ca-dependent events | 0.215389 | 0.667 |
| R-HSA-5683826 | Surfactant metabolism | 0.222978 | 0.652 |
| R-HSA-373752 | Netrin-1 signaling | 0.222978 | 0.652 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.226745 | 0.644 |
| R-HSA-774815 | Nucleosome assembly | 0.226745 | 0.644 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.226745 | 0.644 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.230493 | 0.637 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.230493 | 0.637 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.230493 | 0.637 |
| R-HSA-75153 | Apoptotic execution phase | 0.230493 | 0.637 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.234224 | 0.630 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.237937 | 0.624 |
| R-HSA-73893 | DNA Damage Bypass | 0.241633 | 0.617 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.252613 | 0.598 |
| R-HSA-72187 | mRNA 3'-end processing | 0.252613 | 0.598 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.252613 | 0.598 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.256238 | 0.591 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.256238 | 0.591 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.256238 | 0.591 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.259846 | 0.585 |
| R-HSA-69275 | G2/M Transition | 0.261638 | 0.582 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.261668 | 0.582 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.263436 | 0.579 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.263436 | 0.579 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.265225 | 0.576 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.267009 | 0.573 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.267009 | 0.573 |
| R-HSA-177929 | Signaling by EGFR | 0.267009 | 0.573 |
| R-HSA-5617833 | Cilium Assembly | 0.268812 | 0.571 |
| R-HSA-1483166 | Synthesis of PA | 0.270565 | 0.568 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.274104 | 0.562 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.275986 | 0.559 |
| R-HSA-180786 | Extension of Telomeres | 0.277626 | 0.557 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.281132 | 0.551 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.281132 | 0.551 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.281132 | 0.551 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.284620 | 0.546 |
| R-HSA-112043 | PLC beta mediated events | 0.284620 | 0.546 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.288092 | 0.540 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.288092 | 0.540 |
| R-HSA-186797 | Signaling by PDGF | 0.288092 | 0.540 |
| R-HSA-72172 | mRNA Splicing | 0.295694 | 0.529 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.301813 | 0.520 |
| R-HSA-112040 | G-protein mediated events | 0.305203 | 0.515 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.305203 | 0.515 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.308576 | 0.511 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.308576 | 0.511 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.311496 | 0.507 |
| R-HSA-913531 | Interferon Signaling | 0.311496 | 0.507 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.315274 | 0.501 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.315274 | 0.501 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.318598 | 0.497 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.318598 | 0.497 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.318598 | 0.497 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.321907 | 0.492 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.321907 | 0.492 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.325200 | 0.488 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.325200 | 0.488 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.331739 | 0.479 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.334857 | 0.475 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.334985 | 0.475 |
| R-HSA-5689603 | UCH proteinases | 0.334985 | 0.475 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.341430 | 0.467 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.341430 | 0.467 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.347814 | 0.459 |
| R-HSA-109582 | Hemostasis | 0.350938 | 0.455 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.354136 | 0.451 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.354136 | 0.451 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.363258 | 0.440 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.368959 | 0.433 |
| R-HSA-72766 | Translation | 0.372515 | 0.429 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.372743 | 0.429 |
| R-HSA-70268 | Pyruvate metabolism | 0.372743 | 0.429 |
| R-HSA-73884 | Base Excision Repair | 0.381846 | 0.418 |
| R-HSA-5688426 | Deubiquitination | 0.385491 | 0.414 |
| R-HSA-391251 | Protein folding | 0.390820 | 0.408 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.390820 | 0.408 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.393782 | 0.405 |
| R-HSA-8953854 | Metabolism of RNA | 0.400464 | 0.397 |
| R-HSA-157579 | Telomere Maintenance | 0.408382 | 0.389 |
| R-HSA-3214847 | HATs acetylate histones | 0.414125 | 0.383 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.417790 | 0.379 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.426153 | 0.370 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.428241 | 0.368 |
| R-HSA-111885 | Opioid Signalling | 0.428241 | 0.368 |
| R-HSA-418346 | Platelet homeostasis | 0.436549 | 0.360 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.442694 | 0.354 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.444738 | 0.352 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.452809 | 0.344 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.452809 | 0.344 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.454120 | 0.343 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.458126 | 0.339 |
| R-HSA-5693538 | Homology Directed Repair | 0.473771 | 0.324 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.476335 | 0.322 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.486468 | 0.313 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.488970 | 0.311 |
| R-HSA-168256 | Immune System | 0.490310 | 0.310 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.492274 | 0.308 |
| R-HSA-114608 | Platelet degranulation | 0.498862 | 0.302 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.500355 | 0.301 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.501305 | 0.300 |
| R-HSA-1474244 | Extracellular matrix organization | 0.509207 | 0.293 |
| R-HSA-9843745 | Adipogenesis | 0.510960 | 0.292 |
| R-HSA-9909396 | Circadian clock | 0.513345 | 0.290 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.515718 | 0.288 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.524284 | 0.280 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.533184 | 0.273 |
| R-HSA-73894 | DNA Repair | 0.552082 | 0.258 |
| R-HSA-166520 | Signaling by NTRKs | 0.554361 | 0.256 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.558703 | 0.253 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.563002 | 0.249 |
| R-HSA-2142753 | Arachidonate metabolism | 0.563002 | 0.249 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.565136 | 0.248 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.567260 | 0.246 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.579790 | 0.237 |
| R-HSA-109581 | Apoptosis | 0.583886 | 0.234 |
| R-HSA-1280218 | Adaptive Immune System | 0.595340 | 0.225 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.600295 | 0.222 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.605722 | 0.218 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.607650 | 0.216 |
| R-HSA-611105 | Respiratory electron transport | 0.617152 | 0.210 |
| R-HSA-418594 | G alpha (i) signalling events | 0.617202 | 0.210 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.618691 | 0.209 |
| R-HSA-2559583 | Cellular Senescence | 0.620889 | 0.207 |
| R-HSA-392499 | Metabolism of proteins | 0.644239 | 0.191 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.656331 | 0.183 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.661357 | 0.180 |
| R-HSA-5357801 | Programmed Cell Death | 0.666311 | 0.176 |
| R-HSA-6805567 | Keratinization | 0.667946 | 0.175 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.679173 | 0.168 |
| R-HSA-8951664 | Neddylation | 0.691546 | 0.160 |
| R-HSA-597592 | Post-translational protein modification | 0.717070 | 0.144 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.740366 | 0.131 |
| R-HSA-388396 | GPCR downstream signalling | 0.746579 | 0.127 |
| R-HSA-2262752 | Cellular responses to stress | 0.748904 | 0.126 |
| R-HSA-416476 | G alpha (q) signalling events | 0.750406 | 0.125 |
| R-HSA-74160 | Gene expression (Transcription) | 0.762889 | 0.118 |
| R-HSA-1483257 | Phospholipid metabolism | 0.785817 | 0.105 |
| R-HSA-500792 | GPCR ligand binding | 0.799761 | 0.097 |
| R-HSA-372790 | Signaling by GPCR | 0.804723 | 0.094 |
| R-HSA-449147 | Signaling by Interleukins | 0.825243 | 0.083 |
| R-HSA-8978868 | Fatty acid metabolism | 0.877691 | 0.057 |
| R-HSA-168249 | Innate Immune System | 0.900982 | 0.045 |
| R-HSA-6798695 | Neutrophil degranulation | 0.904669 | 0.044 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.928028 | 0.032 |
| R-HSA-212436 | Generic Transcription Pathway | 0.953472 | 0.021 |
| R-HSA-9709957 | Sensory Perception | 0.986637 | 0.006 |
| R-HSA-5663205 | Infectious disease | 0.991781 | 0.004 |
| R-HSA-1643685 | Disease | 0.996605 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999536 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.794 | 0.323 | 1 | 0.850 |
CLK3 |
0.793 | 0.299 | 1 | 0.805 |
COT |
0.786 | 0.113 | 2 | 0.830 |
NLK |
0.784 | 0.317 | 1 | 0.854 |
HIPK2 |
0.779 | 0.333 | 1 | 0.835 |
SRPK1 |
0.779 | 0.195 | -3 | 0.689 |
MOS |
0.778 | 0.140 | 1 | 0.726 |
DYRK2 |
0.777 | 0.317 | 1 | 0.863 |
CDK1 |
0.777 | 0.330 | 1 | 0.839 |
JNK2 |
0.776 | 0.363 | 1 | 0.840 |
MTOR |
0.776 | 0.096 | 1 | 0.730 |
JNK3 |
0.776 | 0.362 | 1 | 0.851 |
CDK8 |
0.776 | 0.302 | 1 | 0.834 |
ERK5 |
0.776 | 0.174 | 1 | 0.806 |
HIPK1 |
0.776 | 0.328 | 1 | 0.867 |
CDK7 |
0.775 | 0.301 | 1 | 0.848 |
CDK19 |
0.774 | 0.302 | 1 | 0.821 |
CDKL1 |
0.774 | 0.120 | -3 | 0.723 |
CLK2 |
0.774 | 0.252 | -3 | 0.683 |
PIM3 |
0.774 | 0.091 | -3 | 0.761 |
P38G |
0.774 | 0.347 | 1 | 0.801 |
CDKL5 |
0.773 | 0.119 | -3 | 0.708 |
SRPK2 |
0.773 | 0.182 | -3 | 0.610 |
SRPK3 |
0.773 | 0.181 | -3 | 0.667 |
CDK5 |
0.773 | 0.323 | 1 | 0.846 |
CDK10 |
0.772 | 0.358 | 1 | 0.837 |
ERK1 |
0.772 | 0.324 | 1 | 0.842 |
CDK18 |
0.772 | 0.318 | 1 | 0.820 |
CDK17 |
0.772 | 0.329 | 1 | 0.797 |
CLK1 |
0.772 | 0.226 | -3 | 0.669 |
CDK13 |
0.770 | 0.304 | 1 | 0.841 |
HIPK4 |
0.770 | 0.186 | 1 | 0.818 |
PRPK |
0.769 | -0.004 | -1 | 0.701 |
CLK4 |
0.769 | 0.187 | -3 | 0.689 |
CDK3 |
0.769 | 0.307 | 1 | 0.811 |
DYRK4 |
0.769 | 0.327 | 1 | 0.843 |
PKN3 |
0.769 | 0.077 | -3 | 0.734 |
PIM1 |
0.768 | 0.121 | -3 | 0.720 |
CDK12 |
0.768 | 0.309 | 1 | 0.831 |
ICK |
0.767 | 0.152 | -3 | 0.751 |
CDK16 |
0.767 | 0.335 | 1 | 0.805 |
DYRK1B |
0.767 | 0.319 | 1 | 0.839 |
P38A |
0.767 | 0.310 | 1 | 0.859 |
NDR2 |
0.767 | 0.028 | -3 | 0.769 |
NUAK2 |
0.767 | 0.065 | -3 | 0.756 |
CDC7 |
0.767 | -0.042 | 1 | 0.683 |
P38B |
0.767 | 0.314 | 1 | 0.842 |
ERK2 |
0.767 | 0.312 | 1 | 0.844 |
HIPK3 |
0.766 | 0.303 | 1 | 0.857 |
RSK2 |
0.766 | 0.086 | -3 | 0.691 |
DYRK1A |
0.765 | 0.257 | 1 | 0.851 |
MST4 |
0.765 | 0.082 | 2 | 0.881 |
CAMK1B |
0.764 | 0.027 | -3 | 0.770 |
CDK14 |
0.764 | 0.308 | 1 | 0.842 |
P90RSK |
0.764 | 0.072 | -3 | 0.689 |
PKCD |
0.764 | 0.089 | 2 | 0.830 |
CDK9 |
0.764 | 0.295 | 1 | 0.846 |
PKN2 |
0.763 | 0.079 | -3 | 0.756 |
NDR1 |
0.763 | 0.038 | -3 | 0.752 |
TGFBR2 |
0.762 | -0.021 | -2 | 0.699 |
DYRK3 |
0.762 | 0.251 | 1 | 0.854 |
GRK1 |
0.762 | 0.077 | -2 | 0.626 |
CDK2 |
0.761 | 0.239 | 1 | 0.851 |
BMPR2 |
0.761 | -0.073 | -2 | 0.722 |
SKMLCK |
0.761 | 0.010 | -2 | 0.757 |
BMPR1B |
0.761 | 0.085 | 1 | 0.669 |
RSK3 |
0.761 | 0.073 | -3 | 0.688 |
TBK1 |
0.761 | -0.083 | 1 | 0.601 |
MLK1 |
0.761 | 0.020 | 2 | 0.830 |
WNK1 |
0.760 | 0.018 | -2 | 0.742 |
P70S6KB |
0.760 | 0.111 | -3 | 0.709 |
NIK |
0.760 | 0.036 | -3 | 0.788 |
DSTYK |
0.760 | -0.034 | 2 | 0.852 |
CAMK2G |
0.759 | -0.029 | 2 | 0.775 |
CAMLCK |
0.759 | 0.036 | -2 | 0.704 |
IKKB |
0.759 | -0.081 | -2 | 0.551 |
PKACG |
0.759 | 0.047 | -2 | 0.663 |
RAF1 |
0.759 | -0.100 | 1 | 0.677 |
PDHK4 |
0.759 | -0.203 | 1 | 0.711 |
GCN2 |
0.759 | -0.116 | 2 | 0.778 |
RSK4 |
0.758 | 0.114 | -3 | 0.672 |
ATR |
0.757 | -0.061 | 1 | 0.634 |
DAPK2 |
0.756 | 0.016 | -3 | 0.769 |
NEK6 |
0.756 | -0.049 | -2 | 0.746 |
IKKE |
0.756 | -0.103 | 1 | 0.594 |
AMPKA1 |
0.756 | 0.001 | -3 | 0.765 |
PRKD2 |
0.755 | 0.040 | -3 | 0.695 |
RIPK3 |
0.755 | -0.060 | 3 | 0.662 |
GRK7 |
0.755 | 0.065 | 1 | 0.658 |
P38D |
0.755 | 0.312 | 1 | 0.783 |
PRKD1 |
0.755 | 0.017 | -3 | 0.732 |
IRE2 |
0.754 | 0.052 | 2 | 0.791 |
PKCG |
0.754 | 0.068 | 2 | 0.787 |
PKCA |
0.754 | 0.080 | 2 | 0.792 |
GRK5 |
0.754 | -0.100 | -3 | 0.780 |
GRK6 |
0.753 | -0.014 | 1 | 0.688 |
CDK6 |
0.753 | 0.315 | 1 | 0.831 |
SGK3 |
0.753 | 0.097 | -3 | 0.688 |
NEK7 |
0.753 | -0.098 | -3 | 0.755 |
PKCB |
0.753 | 0.066 | 2 | 0.790 |
MLK3 |
0.752 | 0.041 | 2 | 0.790 |
LATS2 |
0.752 | -0.025 | -5 | 0.659 |
CDK4 |
0.752 | 0.319 | 1 | 0.822 |
TSSK2 |
0.752 | 0.007 | -5 | 0.670 |
JNK1 |
0.752 | 0.296 | 1 | 0.834 |
TSSK1 |
0.752 | 0.006 | -3 | 0.776 |
PDHK1 |
0.751 | -0.198 | 1 | 0.687 |
PKACB |
0.751 | 0.053 | -2 | 0.614 |
PIM2 |
0.751 | 0.127 | -3 | 0.663 |
ALK4 |
0.751 | 0.011 | -2 | 0.696 |
WNK3 |
0.751 | -0.100 | 1 | 0.638 |
MAPKAPK3 |
0.750 | -0.009 | -3 | 0.692 |
MARK4 |
0.750 | -0.049 | 4 | 0.728 |
AMPKA2 |
0.750 | 0.002 | -3 | 0.738 |
AURC |
0.750 | 0.009 | -2 | 0.584 |
ULK2 |
0.750 | -0.157 | 2 | 0.774 |
ACVR2B |
0.750 | 0.046 | -2 | 0.687 |
AKT2 |
0.750 | 0.072 | -3 | 0.623 |
ACVR2A |
0.749 | 0.033 | -2 | 0.671 |
HUNK |
0.749 | -0.089 | 2 | 0.765 |
IRE1 |
0.749 | -0.019 | 1 | 0.615 |
MASTL |
0.749 | -0.155 | -2 | 0.646 |
PKG2 |
0.749 | 0.051 | -2 | 0.616 |
LATS1 |
0.749 | 0.019 | -3 | 0.765 |
CAMK4 |
0.749 | -0.025 | -3 | 0.729 |
CK1E |
0.749 | 0.089 | -3 | 0.594 |
TGFBR1 |
0.749 | 0.007 | -2 | 0.685 |
MYLK4 |
0.749 | 0.027 | -2 | 0.658 |
CHAK2 |
0.748 | -0.065 | -1 | 0.631 |
MSK1 |
0.748 | 0.031 | -3 | 0.677 |
MSK2 |
0.748 | 0.003 | -3 | 0.677 |
PKCH |
0.748 | 0.045 | 2 | 0.777 |
MAPKAPK2 |
0.748 | 0.013 | -3 | 0.662 |
MAK |
0.748 | 0.217 | -2 | 0.639 |
PHKG1 |
0.748 | 0.009 | -3 | 0.739 |
MLK4 |
0.748 | 0.026 | 2 | 0.747 |
PLK1 |
0.747 | -0.030 | -2 | 0.678 |
PRKX |
0.747 | 0.066 | -3 | 0.629 |
GRK4 |
0.747 | -0.088 | -2 | 0.684 |
PRKD3 |
0.747 | 0.030 | -3 | 0.673 |
IKKA |
0.746 | -0.067 | -2 | 0.555 |
CAMK2B |
0.746 | -0.009 | 2 | 0.726 |
DLK |
0.746 | -0.091 | 1 | 0.671 |
MLK2 |
0.746 | -0.056 | 2 | 0.802 |
BCKDK |
0.746 | -0.145 | -1 | 0.638 |
PRP4 |
0.745 | 0.163 | -3 | 0.689 |
ATM |
0.745 | -0.064 | 1 | 0.567 |
CAMK2A |
0.744 | 0.005 | 2 | 0.755 |
ALK2 |
0.744 | 0.013 | -2 | 0.686 |
AURB |
0.744 | 0.008 | -2 | 0.567 |
NUAK1 |
0.744 | -0.030 | -3 | 0.707 |
ANKRD3 |
0.744 | -0.101 | 1 | 0.690 |
CAMK2D |
0.744 | -0.076 | -3 | 0.737 |
BMPR1A |
0.744 | 0.050 | 1 | 0.644 |
MOK |
0.744 | 0.230 | 1 | 0.837 |
YSK4 |
0.743 | -0.032 | 1 | 0.616 |
NEK9 |
0.743 | -0.112 | 2 | 0.823 |
PAK1 |
0.743 | -0.013 | -2 | 0.645 |
BRSK1 |
0.743 | 0.009 | -3 | 0.711 |
ERK7 |
0.743 | 0.132 | 2 | 0.556 |
QSK |
0.743 | -0.023 | 4 | 0.705 |
MELK |
0.742 | -0.019 | -3 | 0.709 |
TTBK2 |
0.742 | -0.108 | 2 | 0.656 |
GRK2 |
0.742 | -0.014 | -2 | 0.579 |
RIPK1 |
0.742 | -0.135 | 1 | 0.651 |
PKCZ |
0.741 | -0.022 | 2 | 0.788 |
QIK |
0.741 | -0.063 | -3 | 0.731 |
FAM20C |
0.741 | 0.004 | 2 | 0.550 |
MNK1 |
0.741 | -0.009 | -2 | 0.683 |
DRAK1 |
0.741 | -0.001 | 1 | 0.644 |
PKR |
0.741 | -0.006 | 1 | 0.664 |
ULK1 |
0.741 | -0.154 | -3 | 0.713 |
PAK3 |
0.741 | -0.027 | -2 | 0.634 |
NIM1 |
0.740 | -0.085 | 3 | 0.694 |
AKT1 |
0.740 | 0.064 | -3 | 0.638 |
PKCT |
0.739 | 0.039 | 2 | 0.784 |
MNK2 |
0.739 | -0.050 | -2 | 0.676 |
GSK3A |
0.739 | 0.077 | 4 | 0.378 |
VRK2 |
0.739 | -0.072 | 1 | 0.734 |
SIK |
0.738 | -0.018 | -3 | 0.678 |
MARK3 |
0.738 | -0.014 | 4 | 0.682 |
CAMK1G |
0.738 | 0.008 | -3 | 0.674 |
P70S6K |
0.738 | 0.109 | -3 | 0.623 |
MST3 |
0.738 | 0.067 | 2 | 0.847 |
PAK2 |
0.738 | -0.030 | -2 | 0.615 |
BRSK2 |
0.737 | -0.046 | -3 | 0.720 |
AURA |
0.737 | -0.018 | -2 | 0.528 |
PLK3 |
0.737 | -0.049 | 2 | 0.725 |
SSTK |
0.737 | 0.035 | 4 | 0.720 |
SGK1 |
0.737 | 0.102 | -3 | 0.556 |
MEK1 |
0.736 | -0.115 | 2 | 0.793 |
PASK |
0.736 | 0.045 | -3 | 0.784 |
PKACA |
0.736 | 0.032 | -2 | 0.579 |
CK1D |
0.736 | 0.068 | -3 | 0.549 |
SMMLCK |
0.736 | 0.027 | -3 | 0.729 |
DCAMKL1 |
0.735 | -0.007 | -3 | 0.710 |
PKCE |
0.735 | 0.072 | 2 | 0.782 |
NEK2 |
0.735 | -0.065 | 2 | 0.803 |
PHKG2 |
0.735 | 0.017 | -3 | 0.707 |
MEKK3 |
0.735 | -0.053 | 1 | 0.648 |
TAO3 |
0.734 | 0.028 | 1 | 0.647 |
CK1A2 |
0.734 | 0.068 | -3 | 0.552 |
DNAPK |
0.734 | -0.047 | 1 | 0.530 |
MARK2 |
0.733 | -0.042 | 4 | 0.643 |
AKT3 |
0.733 | 0.069 | -3 | 0.575 |
SNRK |
0.733 | -0.078 | 2 | 0.686 |
CHAK1 |
0.733 | -0.092 | 2 | 0.724 |
MPSK1 |
0.733 | 0.045 | 1 | 0.670 |
HRI |
0.733 | -0.081 | -2 | 0.715 |
PLK4 |
0.733 | -0.085 | 2 | 0.627 |
WNK4 |
0.732 | -0.045 | -2 | 0.726 |
MEK5 |
0.732 | -0.085 | 2 | 0.804 |
SMG1 |
0.732 | -0.096 | 1 | 0.576 |
MEKK2 |
0.731 | -0.030 | 2 | 0.788 |
GRK3 |
0.731 | -0.018 | -2 | 0.553 |
MEKK1 |
0.731 | -0.084 | 1 | 0.636 |
MARK1 |
0.730 | -0.047 | 4 | 0.706 |
PERK |
0.730 | -0.110 | -2 | 0.693 |
ZAK |
0.730 | -0.084 | 1 | 0.621 |
IRAK4 |
0.730 | -0.050 | 1 | 0.613 |
CK2A2 |
0.730 | 0.064 | 1 | 0.590 |
GAK |
0.730 | 0.073 | 1 | 0.715 |
PINK1 |
0.730 | -0.029 | 1 | 0.752 |
NEK11 |
0.729 | -0.013 | 1 | 0.654 |
TLK2 |
0.729 | -0.122 | 1 | 0.589 |
DCAMKL2 |
0.728 | -0.025 | -3 | 0.722 |
TAO2 |
0.728 | 0.025 | 2 | 0.861 |
NEK5 |
0.728 | -0.072 | 1 | 0.642 |
PKCI |
0.727 | 0.001 | 2 | 0.780 |
GSK3B |
0.727 | -0.008 | 4 | 0.370 |
DAPK3 |
0.726 | 0.024 | -3 | 0.724 |
PAK6 |
0.726 | -0.049 | -2 | 0.537 |
CHK1 |
0.726 | -0.093 | -3 | 0.728 |
CK1G1 |
0.726 | 0.001 | -3 | 0.593 |
PKN1 |
0.726 | 0.025 | -3 | 0.636 |
DAPK1 |
0.725 | 0.031 | -3 | 0.713 |
GCK |
0.725 | 0.033 | 1 | 0.652 |
CAMK1D |
0.724 | -0.009 | -3 | 0.617 |
EEF2K |
0.724 | 0.030 | 3 | 0.781 |
TLK1 |
0.723 | -0.099 | -2 | 0.736 |
PDK1 |
0.723 | -0.027 | 1 | 0.683 |
MRCKB |
0.722 | 0.052 | -3 | 0.662 |
BRAF |
0.722 | -0.125 | -4 | 0.759 |
HPK1 |
0.722 | 0.030 | 1 | 0.646 |
CK2A1 |
0.721 | 0.054 | 1 | 0.573 |
MAPKAPK5 |
0.721 | -0.095 | -3 | 0.626 |
NEK8 |
0.721 | -0.091 | 2 | 0.825 |
ROCK2 |
0.720 | 0.057 | -3 | 0.708 |
MRCKA |
0.720 | 0.037 | -3 | 0.673 |
MAP3K15 |
0.719 | -0.028 | 1 | 0.616 |
KHS2 |
0.719 | 0.071 | 1 | 0.643 |
MST2 |
0.719 | -0.032 | 1 | 0.640 |
TNIK |
0.718 | 0.030 | 3 | 0.778 |
CAMK1A |
0.718 | 0.007 | -3 | 0.602 |
IRAK1 |
0.718 | -0.163 | -1 | 0.631 |
CHK2 |
0.717 | 0.000 | -3 | 0.570 |
HGK |
0.717 | -0.009 | 3 | 0.776 |
MINK |
0.716 | -0.022 | 1 | 0.625 |
DMPK1 |
0.716 | 0.072 | -3 | 0.689 |
KHS1 |
0.716 | 0.039 | 1 | 0.628 |
MEKK6 |
0.716 | -0.047 | 1 | 0.620 |
LRRK2 |
0.716 | -0.036 | 2 | 0.835 |
TAK1 |
0.715 | -0.014 | 1 | 0.647 |
TTBK1 |
0.715 | -0.136 | 2 | 0.583 |
LOK |
0.715 | -0.010 | -2 | 0.621 |
CRIK |
0.715 | 0.142 | -3 | 0.636 |
PLK2 |
0.714 | -0.027 | -3 | 0.740 |
BUB1 |
0.712 | 0.027 | -5 | 0.665 |
MST1 |
0.712 | -0.022 | 1 | 0.619 |
PAK5 |
0.712 | -0.067 | -2 | 0.493 |
ROCK1 |
0.712 | 0.063 | -3 | 0.672 |
VRK1 |
0.711 | -0.066 | 2 | 0.817 |
NEK4 |
0.711 | -0.105 | 1 | 0.611 |
SBK |
0.710 | 0.024 | -3 | 0.514 |
TTK |
0.709 | 0.013 | -2 | 0.718 |
SLK |
0.709 | -0.061 | -2 | 0.570 |
PAK4 |
0.708 | -0.064 | -2 | 0.501 |
PKG1 |
0.708 | -0.003 | -2 | 0.548 |
LKB1 |
0.708 | -0.134 | -3 | 0.736 |
PBK |
0.708 | 0.004 | 1 | 0.640 |
HASPIN |
0.707 | 0.009 | -1 | 0.513 |
YSK1 |
0.707 | -0.036 | 2 | 0.821 |
CAMKK1 |
0.706 | -0.198 | -2 | 0.548 |
NEK1 |
0.706 | -0.108 | 1 | 0.624 |
CAMKK2 |
0.704 | -0.185 | -2 | 0.551 |
RIPK2 |
0.702 | -0.185 | 1 | 0.587 |
BIKE |
0.702 | 0.034 | 1 | 0.635 |
OSR1 |
0.702 | -0.032 | 2 | 0.781 |
ALPHAK3 |
0.701 | 0.004 | -1 | 0.616 |
STK33 |
0.699 | -0.133 | 2 | 0.596 |
TAO1 |
0.698 | -0.027 | 1 | 0.575 |
MEK2 |
0.697 | -0.211 | 2 | 0.770 |
MYO3B |
0.695 | -0.019 | 2 | 0.831 |
CK1A |
0.695 | 0.008 | -3 | 0.482 |
ASK1 |
0.694 | -0.074 | 1 | 0.611 |
MYO3A |
0.694 | -0.018 | 1 | 0.614 |
PDHK3_TYR |
0.693 | 0.091 | 4 | 0.763 |
NEK3 |
0.692 | -0.136 | 1 | 0.599 |
PDHK4_TYR |
0.691 | 0.106 | 2 | 0.841 |
TESK1_TYR |
0.689 | 0.075 | 3 | 0.782 |
AAK1 |
0.689 | 0.053 | 1 | 0.565 |
YANK3 |
0.689 | -0.049 | 2 | 0.374 |
BMPR2_TYR |
0.689 | 0.135 | -1 | 0.749 |
MAP2K6_TYR |
0.689 | 0.057 | -1 | 0.726 |
PINK1_TYR |
0.687 | 0.077 | 1 | 0.701 |
PDHK1_TYR |
0.687 | 0.079 | -1 | 0.727 |
PKMYT1_TYR |
0.685 | 0.037 | 3 | 0.742 |
MAP2K7_TYR |
0.685 | -0.033 | 2 | 0.830 |
MAP2K4_TYR |
0.684 | -0.044 | -1 | 0.712 |
TXK |
0.682 | 0.076 | 1 | 0.677 |
EPHA6 |
0.682 | 0.092 | -1 | 0.709 |
LIMK2_TYR |
0.681 | 0.017 | -3 | 0.782 |
RET |
0.677 | -0.028 | 1 | 0.649 |
YES1 |
0.677 | 0.008 | -1 | 0.702 |
LCK |
0.676 | 0.080 | -1 | 0.748 |
LIMK1_TYR |
0.676 | -0.056 | 2 | 0.835 |
STLK3 |
0.675 | -0.147 | 1 | 0.581 |
CK1G3 |
0.675 | -0.007 | -3 | 0.449 |
TYRO3 |
0.675 | -0.061 | 3 | 0.692 |
EPHB4 |
0.675 | -0.005 | -1 | 0.689 |
ROS1 |
0.675 | -0.047 | 3 | 0.673 |
TYK2 |
0.674 | -0.079 | 1 | 0.640 |
JAK3 |
0.673 | 0.009 | 1 | 0.633 |
ITK |
0.673 | 0.019 | -1 | 0.712 |
BLK |
0.673 | 0.073 | -1 | 0.738 |
FYN |
0.673 | 0.097 | -1 | 0.754 |
DDR1 |
0.672 | -0.081 | 4 | 0.734 |
INSRR |
0.672 | -0.026 | 3 | 0.643 |
CSF1R |
0.672 | -0.054 | 3 | 0.678 |
FGR |
0.671 | -0.044 | 1 | 0.684 |
MST1R |
0.671 | -0.074 | 3 | 0.691 |
HCK |
0.671 | 0.001 | -1 | 0.742 |
JAK2 |
0.669 | -0.093 | 1 | 0.648 |
KDR |
0.669 | -0.006 | 3 | 0.660 |
ABL2 |
0.668 | -0.033 | -1 | 0.636 |
FGFR2 |
0.667 | -0.044 | 3 | 0.677 |
FER |
0.667 | -0.089 | 1 | 0.692 |
BMX |
0.667 | -0.002 | -1 | 0.629 |
WEE1_TYR |
0.666 | -0.007 | -1 | 0.618 |
CK1G2 |
0.665 | 0.005 | -3 | 0.528 |
TEC |
0.664 | -0.044 | -1 | 0.617 |
TNNI3K_TYR |
0.664 | -0.029 | 1 | 0.648 |
FLT3 |
0.664 | -0.057 | 3 | 0.693 |
SRMS |
0.664 | -0.076 | 1 | 0.677 |
KIT |
0.664 | -0.067 | 3 | 0.673 |
NEK10_TYR |
0.663 | -0.068 | 1 | 0.561 |
PDGFRB |
0.663 | -0.113 | 3 | 0.695 |
TEK |
0.663 | -0.044 | 3 | 0.617 |
DDR2 |
0.662 | -0.009 | 3 | 0.619 |
FLT1 |
0.662 | -0.018 | -1 | 0.689 |
MET |
0.662 | -0.027 | 3 | 0.652 |
EPHA4 |
0.662 | -0.048 | 2 | 0.732 |
TNK1 |
0.661 | -0.085 | 3 | 0.671 |
BTK |
0.661 | -0.089 | -1 | 0.662 |
EPHB1 |
0.661 | -0.074 | 1 | 0.664 |
MERTK |
0.661 | -0.075 | 3 | 0.652 |
ABL1 |
0.661 | -0.070 | -1 | 0.623 |
EPHB3 |
0.660 | -0.066 | -1 | 0.682 |
FGFR3 |
0.660 | -0.038 | 3 | 0.655 |
FGFR1 |
0.660 | -0.091 | 3 | 0.654 |
YANK2 |
0.659 | -0.067 | 2 | 0.387 |
JAK1 |
0.659 | -0.072 | 1 | 0.598 |
EPHB2 |
0.659 | -0.064 | -1 | 0.675 |
FRK |
0.658 | -0.026 | -1 | 0.711 |
PTK2 |
0.658 | 0.084 | -1 | 0.730 |
AXL |
0.658 | -0.113 | 3 | 0.656 |
LYN |
0.657 | -0.029 | 3 | 0.615 |
TNK2 |
0.657 | -0.116 | 3 | 0.617 |
PTK6 |
0.655 | -0.138 | -1 | 0.609 |
SRC |
0.655 | -0.019 | -1 | 0.705 |
EPHA1 |
0.655 | -0.069 | 3 | 0.637 |
ALK |
0.655 | -0.113 | 3 | 0.603 |
SYK |
0.654 | 0.062 | -1 | 0.701 |
ERBB2 |
0.654 | -0.087 | 1 | 0.621 |
PDGFRA |
0.653 | -0.174 | 3 | 0.683 |
EPHA7 |
0.652 | -0.066 | 2 | 0.741 |
INSR |
0.652 | -0.106 | 3 | 0.622 |
FLT4 |
0.651 | -0.108 | 3 | 0.647 |
LTK |
0.651 | -0.123 | 3 | 0.622 |
NTRK1 |
0.650 | -0.172 | -1 | 0.656 |
PTK2B |
0.648 | -0.099 | -1 | 0.626 |
EPHA3 |
0.648 | -0.113 | 2 | 0.717 |
EPHA8 |
0.648 | -0.035 | -1 | 0.693 |
NTRK2 |
0.647 | -0.168 | 3 | 0.641 |
EGFR |
0.647 | -0.060 | 1 | 0.555 |
EPHA5 |
0.646 | -0.077 | 2 | 0.725 |
NTRK3 |
0.645 | -0.138 | -1 | 0.615 |
ERBB4 |
0.643 | -0.003 | 1 | 0.574 |
IGF1R |
0.643 | -0.075 | 3 | 0.561 |
MATK |
0.642 | -0.105 | -1 | 0.531 |
FGFR4 |
0.640 | -0.095 | -1 | 0.603 |
CSK |
0.638 | -0.129 | 2 | 0.735 |
EPHA2 |
0.637 | -0.060 | -1 | 0.665 |
ZAP70 |
0.637 | 0.023 | -1 | 0.629 |
MUSK |
0.635 | -0.113 | 1 | 0.538 |
FES |
0.625 | -0.122 | -1 | 0.583 |