Motif 64 (n=208)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2A3K4 | PTPDC1 | S438 | ochoa | Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) | May play roles in cilia formation and/or maintenance. {ECO:0000250}. |
| A6NDB9 | PALM3 | S303 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A6NLC5 | C3orf70 | S158 | ochoa | UPF0524 protein C3orf70 | May play a role in neuronal and neurobehavioral development. {ECO:0000250|UniProtKB:Q1LY84}. |
| A7MCY6 | TBKBP1 | S534 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| E7EW31 | PROB1 | S260 | ochoa | Proline-rich basic protein 1 | None |
| O00327 | BMAL1 | S592 | psp | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O00562 | PITPNM1 | S600 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O00571 | DDX3X | S492 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14492 | SH2B2 | S598 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14526 | FCHO1 | S616 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14715 | RGPD8 | S1742 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15061 | SYNM | S1107 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15085 | ARHGEF11 | S1300 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15119 | TBX3 | S456 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15156 | ZBTB7B | S150 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15523 | DDX3Y | S490 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43242 | PSMD3 | S430 | ochoa | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O43296 | ZNF264 | S155 | ochoa | Zinc finger protein 264 | May be involved in transcriptional regulation. |
| O43353 | RIPK2 | S357 | ochoa | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| O43402 | EMC8 | S103 | ochoa | ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}. |
| O43684 | BUB3 | S211 | ochoa|psp | Mitotic checkpoint protein BUB3 | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}. |
| O60291 | MGRN1 | S524 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60294 | LCMT2 | S20 | ochoa | tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) | Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. {ECO:0000250}. |
| O60331 | PIP5K1C | S453 | ochoa|psp | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| O60343 | TBC1D4 | S106 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60828 | PQBP1 | S247 | ochoa|psp | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| O60930 | RNASEH1 | S76 | ochoa | Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II) | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). {ECO:0000269|PubMed:10497183, ECO:0000269|PubMed:21700224}. |
| O75362 | ZNF217 | S662 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75469 | NR1I2 | S114 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75955 | FLOT1 | S315 | psp | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O94811 | TPPP | S45 | ochoa | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
| O94850 | DDN | S567 | ochoa | Dendrin | Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}. |
| O94880 | PHF14 | S530 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95336 | PGLS | S52 | ochoa | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}. |
| O95425 | SVIL | S97 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95613 | PCNT | S2279 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P00533 | EGFR | S991 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P01034 | CST3 | S43 | ochoa | Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) | As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. |
| P02545 | LMNA | S71 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02647 | APOA1 | S191 | ochoa | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| P04899 | GNAI2 | S144 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05412 | JUN | S73 | ochoa|psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P09327 | VIL1 | S219 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P0DJD0 | RGPD1 | S1725 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1733 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13164 | IFITM1 | S80 | ochoa | Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}. |
| P13796 | LCP1 | S265 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P17535 | JUND | S100 | ochoa|psp | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
| P17542 | TAL1 | S122 | ochoa|psp | T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5) | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. |
| P17861 | XBP1 | S68 | ochoa|psp | X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] | Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}. |
| P23511 | NFYA | S326 | ochoa|psp | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}. |
| P27708 | CAD | S1038 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P27815 | PDE4A | S128 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28906 | CD34 | S346 | ochoa | Hematopoietic progenitor cell antigen CD34 (CD antigen CD34) | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| P29474 | NOS3 | Y657 | psp | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P30038 | ALDH4A1 | S44 | ochoa | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}. |
| P30086 | PEBP1 | S153 | psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P35548 | MSX2 | S91 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P36578 | RPL4 | S295 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P42345 | MTOR | S567 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42704 | LRPPRC | S54 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P46013 | MKI67 | S308 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46060 | RANGAP1 | S301 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P49792 | RANBP2 | S1400 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51814 | ZNF41 | S269 | ochoa | Zinc finger protein 41 | May be involved in transcriptional regulation. |
| P53675 | CLTCL1 | S889 | ochoa | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| P55265 | ADAR | S825 | ochoa|psp | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P61086 | UBE2K | S159 | ochoa | Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:17873885, ECO:0000269|PubMed:19906396, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8702625}. |
| P78395 | PRAME | S277 | ochoa | Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma) | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254). {ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}. |
| Q00653 | NFKB2 | S277 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01167 | FOXK2 | S373 | ochoa|psp | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01628 | IFITM3 | S101 | ochoa | Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U) | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927). {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927}. |
| Q01629 | IFITM2 | S100 | ochoa | Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}. |
| Q08495 | DMTN | S383 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12770 | SCAP | S952 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12904 | AIMP1 | S232 | ochoa | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}. |
| Q13415 | ORC1 | S311 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13501 | SQSTM1 | S28 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13572 | ITPK1 | S396 | ochoa | Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159) | Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:11909533, PubMed:17616525). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11042108, ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525, ECO:0000269|PubMed:8662638}. |
| Q13627 | DYRK1A | S555 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| Q14160 | SCRIB | S1475 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14197 | MRPL58 | Y49 | ochoa | Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29) | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294). {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:33878294}. |
| Q14247 | CTTN | S447 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14524 | SCN5A | S577 | ochoa | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14687 | GSE1 | S970 | ochoa | Genetic suppressor element 1 | None |
| Q147X3 | NAA30 | S89 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14966 | ZNF638 | S420 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q16625 | OCLN | S378 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2M1P5 | KIF7 | S1289 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q32MQ0 | ZNF750 | S136 | ochoa | Zinc finger protein 750 | Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}. |
| Q3MIN7 | RGL3 | S52 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q4KMZ1 | IQCC | S438 | ochoa | IQ domain-containing protein C | None |
| Q53ET0 | CRTC2 | S624 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q562E7 | WDR81 | S686 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5HYI7 | MTX3 | S249 | ochoa | Metaxin-3 | Could function in transport of proteins into the mitochondrion. {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S168 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTC6 | AMER1 | S286 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5VT06 | CEP350 | S1653 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VV41 | ARHGEF16 | S240 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VVJ2 | MYSM1 | S340 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q66K74 | MAP1S | S741 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q66K89 | E4F1 | S318 | ochoa | Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. |
| Q6IQ23 | PLEKHA7 | S363 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NSJ2 | PHLDB3 | S412 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6UB99 | ANKRD11 | S609 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6WKZ4 | RAB11FIP1 | S1214 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZN17 | LIN28B | S203 | ochoa | Protein lin-28 homolog B (Lin-28B) | Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000250|UniProtKB:Q45KJ6, ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22118463}. |
| Q765P7 | MTSS2 | S649 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L590 | MCM10 | S644 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z3J3 | RGPD4 | S1743 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z4V5 | HDGFL2 | S490 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z591 | AKNA | S997 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z6J2 | TAMALIN | S94 | ochoa | Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) | Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | S2835 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U28 | ISCA2 | S29 | ochoa | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:22323289}. |
| Q86U90 | YRDC | S60 | ochoa | Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) | Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250|UniProtKB:Q3U5F4, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:31481669, ECO:0000269|PubMed:34545459}. |
| Q86UU0 | BCL9L | S813 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S334 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86X29 | LSR | S467 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XP1 | DGKH | S1075 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q86YP4 | GATAD2A | S337 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q86YP4 | GATAD2A | S546 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IV36 | HID1 | S653 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IVL0 | NAV3 | S1245 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IWJ2 | GCC2 | S1649 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IYB8 | SUPV3L1 | S725 | ochoa | ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1) | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255, ECO:0000269|PubMed:29967381}. |
| Q8N196 | SIX5 | S283 | ochoa | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}. |
| Q8N3R9 | PALS1 | S25 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N4X5 | AFAP1L2 | S767 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N554 | ZNF276 | S160 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8NB78 | KDM1B | S247 | ochoa | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}. |
| Q8NDX1 | PSD4 | S565 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEG4 | FAM83F | S61 | ochoa | Protein FAM83F | None |
| Q8NEY1 | NAV1 | S541 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFU0 | BEST4 | S397 | ochoa | Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985). {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}. |
| Q8TAB3 | PCDH19 | S983 | ochoa | Protocadherin-19 | Calcium-dependent cell-adhesion protein. {ECO:0000250|UniProtKB:F8W3X3}. |
| Q8TER5 | ARHGEF40 | S961 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TEW0 | PARD3 | S1116 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TEX9 | IPO4 | S972 | ochoa | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485}. |
| Q8WWW8 | GAB3 | S482 | ochoa | GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3) | None |
| Q92508 | PIEZO1 | S165 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92560 | BAP1 | S597 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92665 | MRPS31 | S152 | ochoa | Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38) | None |
| Q92858 | ATOH1 | S84 | ochoa | Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1) | Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P48985}. |
| Q92917 | GPKOW | S42 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q92994 | BRF1 | S398 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96C19 | EFHD2 | T24 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96EV2 | RBM33 | S765 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96G74 | OTUD5 | S165 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96JN8 | NEURL4 | S502 | ochoa | Neuralized-like protein 4 | Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
| Q96NY7 | CLIC6 | S322 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q96PX6 | CCDC85A | S255 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q99575 | POP1 | S95 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q99666 | RGPD5 | S1742 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99735 | MGST2 | S43 | ochoa | Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II) | Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:23409838, PubMed:9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610, ECO:0000269|PubMed:26656251, ECO:0000269|PubMed:8703034, ECO:0000269|PubMed:9278457}. |
| Q9BSI4 | TINF2 | S305 | ochoa | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}. |
| Q9BZC7 | ABCA2 | S1351 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9C0C2 | TNKS1BP1 | S494 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0K0 | BCL11B | S497 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H079 | KATNBL1 | S89 | ochoa | KATNB1-like protein 1 (Katanin p80 subunit B-like 1) | Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}. |
| Q9H0E3 | SAP130 | S442 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H2Y7 | ZNF106 | S1205 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H6X4 | TMEM134 | S70 | ochoa | Transmembrane protein 134 | None |
| Q9H7M9 | VSIR | S248 | ochoa | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}. |
| Q9HCC9 | ZFYVE28 | S523 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9HD20 | ATP13A1 | S945 | ochoa | Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) | Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}. |
| Q9NR34 | MAN1C1 | S164 | ochoa | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) | Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. |
| Q9NVE7 | PANK4 | S393 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NVF7 | FBXO28 | S235 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9NWA0 | MED9 | S80 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9NYP3 | DONSON | S34 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NZ56 | FMN2 | S93 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZB2 | FAM120A | S652 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZC9 | SMARCAL1 | S151 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZJ0 | DTL | S656 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P1Y5 | CAMSAP3 | S193 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P219 | CCDC88C | S1825 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P275 | USP36 | S582 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2G1 | ANKIB1 | S737 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UBC3 | DNMT3B | S31 | ochoa | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}. |
| Q9UDY2 | TJP2 | S130 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UFC0 | LRWD1 | S212 | ochoa | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}. |
| Q9UKJ3 | GPATCH8 | S1081 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULC4 | MCTS1 | S118 | ochoa|psp | Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies) | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation (PubMed:16982740, PubMed:20713520, PubMed:37875108). This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent (PubMed:16982740, PubMed:20713520, PubMed:37875108). Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair (PubMed:10440924, PubMed:11709712, PubMed:12637315, PubMed:15897892, PubMed:16322206, PubMed:17016429, PubMed:17416211, PubMed:9766643). Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2 (PubMed:37875108). {ECO:0000269|PubMed:10440924, ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:12637315, ECO:0000269|PubMed:15897892, ECO:0000269|PubMed:16322206, ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17016429, ECO:0000269|PubMed:17416211, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:37875108, ECO:0000269|PubMed:9766643}. |
| Q9UNZ2 | NSFL1C | S272 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN3 | MACF1 | S4521 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPR0 | PLCL2 | S71 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9UQ35 | SRRM2 | S1219 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2F5 | ICE1 | S1470 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y485 | DMXL1 | S1905 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4F5 | CEP170B | S597 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S853 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| V9GYH0 | None | S31 | ochoa | Homeobox domain-containing protein | None |
| P36578 | RPL4 | S63 | Sugiyama | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P60174 | TPI1 | S106 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q9Y230 | RUVBL2 | S43 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q14204 | DYNC1H1 | S2410 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| P08754 | GNAI3 | S143 | Sugiyama | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| Q96G03 | PGM2 | S186 | Sugiyama | Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2) | Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed:17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed:17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:17804405). In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed:17804405, PubMed:18927083). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083}. |
| P17936 | IGFBP3 | S97 | Sugiyama | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| O00151 | PDLIM1 | S31 | Sugiyama | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O75128 | COBL | S1174 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| Q13976 | PRKG1 | S332 | Sugiyama | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| O43734 | TRAF3IP2 | S328 | SIGNOR | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}. |
| Q16762 | TST | S35 | Sugiyama | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}. |
| Q99759 | MAP3K3 | S399 | Sugiyama | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9Y2U5 | MAP3K2 | S393 | Sugiyama | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q99798 | ACO2 | S389 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000436 | 3.360 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.015344 | 1.814 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 0.030454 | 1.516 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 0.045333 | 1.344 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 0.045333 | 1.344 |
| R-HSA-5682113 | Defective ABCA1 causes TGD | 0.074413 | 1.128 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.088620 | 1.052 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.102610 | 0.989 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.023014 | 1.638 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.116385 | 0.934 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.116385 | 0.934 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.116385 | 0.934 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.129951 | 0.886 |
| R-HSA-8964011 | HDL clearance | 0.129951 | 0.886 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.129951 | 0.886 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.035476 | 1.450 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.143309 | 0.844 |
| R-HSA-964827 | Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t... | 0.143309 | 0.844 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.156462 | 0.806 |
| R-HSA-196025 | Formation of annular gap junctions | 0.156462 | 0.806 |
| R-HSA-190873 | Gap junction degradation | 0.169415 | 0.771 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.194728 | 0.711 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.194728 | 0.711 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.194728 | 0.711 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.207095 | 0.684 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.207095 | 0.684 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.219273 | 0.659 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.219273 | 0.659 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.219273 | 0.659 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.219273 | 0.659 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.219273 | 0.659 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.102789 | 0.988 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.243073 | 0.614 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.254701 | 0.594 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.254701 | 0.594 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.254701 | 0.594 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.254701 | 0.594 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.254701 | 0.594 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.277425 | 0.557 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.277425 | 0.557 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.288527 | 0.540 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.059403 | 1.226 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.059403 | 1.226 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.320824 | 0.494 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.331261 | 0.480 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.341539 | 0.467 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.341539 | 0.467 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.237646 | 0.624 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.237646 | 0.624 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.243332 | 0.614 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.183016 | 0.738 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.390616 | 0.408 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.399985 | 0.398 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.399985 | 0.398 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.418295 | 0.379 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.300269 | 0.522 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.300269 | 0.522 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.238661 | 0.622 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.311606 | 0.506 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.317260 | 0.499 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.339760 | 0.469 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.356487 | 0.448 |
| R-HSA-380287 | Centrosome maturation | 0.367554 | 0.435 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.418680 | 0.378 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.390616 | 0.408 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.331261 | 0.480 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.331261 | 0.480 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.288527 | 0.540 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.288527 | 0.540 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.021236 | 1.673 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.097952 | 1.009 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.299459 | 0.524 |
| R-HSA-9646399 | Aggrephagy | 0.165017 | 0.782 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.094982 | 1.022 |
| R-HSA-180786 | Extension of Telomeres | 0.277516 | 0.557 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.182169 | 0.740 |
| R-HSA-180292 | GAB1 signalosome | 0.299459 | 0.524 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.107690 | 0.968 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.198139 | 0.703 |
| R-HSA-8964058 | HDL remodeling | 0.310224 | 0.508 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.371438 | 0.430 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.418295 | 0.379 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.102610 | 0.989 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.061969 | 1.208 |
| R-HSA-418457 | cGMP effects | 0.243073 | 0.614 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.254701 | 0.594 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.341539 | 0.467 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.389459 | 0.410 |
| R-HSA-420029 | Tight junction interactions | 0.083859 | 1.076 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.219273 | 0.659 |
| R-HSA-8963901 | Chylomicron remodeling | 0.231265 | 0.636 |
| R-HSA-8963896 | HDL assembly | 0.243073 | 0.614 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.277425 | 0.557 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.170470 | 0.768 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.381101 | 0.419 |
| R-HSA-9909396 | Circadian clock | 0.197654 | 0.704 |
| R-HSA-5689603 | UCH proteinases | 0.042541 | 1.371 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.106418 | 0.973 |
| R-HSA-991365 | Activation of GABAB receptors | 0.181463 | 0.741 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.254719 | 0.594 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.001732 | 2.761 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.169415 | 0.771 |
| R-HSA-8963888 | Chylomicron assembly | 0.194728 | 0.711 |
| R-HSA-964739 | N-glycan trimming and elongation in the cis-Golgi | 0.243073 | 0.614 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 0.277425 | 0.557 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.351660 | 0.454 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.102789 | 0.988 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.170470 | 0.768 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.121420 | 0.916 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.117673 | 0.929 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.025924 | 1.586 |
| R-HSA-977444 | GABA B receptor activation | 0.181463 | 0.741 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.035476 | 1.450 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.170470 | 0.768 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.260418 | 0.584 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.288329 | 0.540 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.011466 | 1.941 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.030454 | 1.516 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.059985 | 1.222 |
| R-HSA-75102 | C6 deamination of adenosine | 0.059985 | 1.222 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.074413 | 1.128 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.088620 | 1.052 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.116385 | 0.934 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.116385 | 0.934 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.182169 | 0.740 |
| R-HSA-4839744 | Signaling by APC mutants | 0.194728 | 0.711 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.207095 | 0.684 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.207095 | 0.684 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.254701 | 0.594 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.277425 | 0.557 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.371438 | 0.430 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.390616 | 0.408 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.409211 | 0.388 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.356487 | 0.448 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.313485 | 0.504 |
| R-HSA-9843745 | Adipogenesis | 0.397136 | 0.401 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.299459 | 0.524 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.371438 | 0.430 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.032160 | 1.493 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.288527 | 0.540 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.310224 | 0.508 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.198139 | 0.703 |
| R-HSA-9620244 | Long-term potentiation | 0.381101 | 0.419 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.345352 | 0.462 |
| R-HSA-977443 | GABA receptor activation | 0.283211 | 0.548 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.035301 | 1.452 |
| R-HSA-70688 | Proline catabolism | 0.219273 | 0.659 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.022030 | 1.657 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.080868 | 1.092 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.243073 | 0.614 |
| R-HSA-6782861 | Synthesis of wybutosine at G37 of tRNA(Phe) | 0.266151 | 0.575 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.153491 | 0.814 |
| R-HSA-9663891 | Selective autophagy | 0.190749 | 0.720 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.345352 | 0.462 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.345352 | 0.462 |
| R-HSA-69306 | DNA Replication | 0.273220 | 0.563 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.045333 | 1.344 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.007025 | 2.153 |
| R-HSA-8964046 | VLDL clearance | 0.143309 | 0.844 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.143309 | 0.844 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.049956 | 1.301 |
| R-HSA-75072 | mRNA Editing | 0.169415 | 0.771 |
| R-HSA-1483226 | Synthesis of PI | 0.194728 | 0.711 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.310224 | 0.508 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.310224 | 0.508 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.331261 | 0.480 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.371438 | 0.430 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.416356 | 0.381 |
| R-HSA-68877 | Mitotic Prometaphase | 0.232563 | 0.633 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.165017 | 0.782 |
| R-HSA-9664873 | Pexophagy | 0.182169 | 0.740 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.158276 | 0.801 |
| R-HSA-9612973 | Autophagy | 0.283453 | 0.548 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.002465 | 2.608 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.079312 | 1.101 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.154210 | 0.812 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.165017 | 0.782 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.209357 | 0.679 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.243073 | 0.614 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.320824 | 0.494 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.399985 | 0.398 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.294589 | 0.531 |
| R-HSA-5334118 | DNA methylation | 0.418295 | 0.379 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.074845 | 1.126 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.350927 | 0.455 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.416356 | 0.381 |
| R-HSA-1632852 | Macroautophagy | 0.229760 | 0.639 |
| R-HSA-8953854 | Metabolism of RNA | 0.253183 | 0.597 |
| R-HSA-71336 | Pentose phosphate pathway | 0.035301 | 1.452 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.310224 | 0.508 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.341539 | 0.467 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.351660 | 0.454 |
| R-HSA-429947 | Deadenylation of mRNA | 0.371438 | 0.430 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.399985 | 0.398 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.350927 | 0.455 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.394884 | 0.404 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.305942 | 0.514 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.209357 | 0.679 |
| R-HSA-75153 | Apoptotic execution phase | 0.010334 | 1.986 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.122749 | 0.911 |
| R-HSA-1640170 | Cell Cycle | 0.240608 | 0.619 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.294589 | 0.531 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.012885 | 1.890 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.102610 | 0.989 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.116385 | 0.934 |
| R-HSA-448706 | Interleukin-1 processing | 0.169415 | 0.771 |
| R-HSA-9707616 | Heme signaling | 0.024164 | 1.617 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.254701 | 0.594 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.029173 | 1.535 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.299459 | 0.524 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.310224 | 0.508 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.341539 | 0.467 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.119667 | 0.922 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.390616 | 0.408 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.277516 | 0.557 |
| R-HSA-68886 | M Phase | 0.287066 | 0.542 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.210605 | 0.677 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.421665 | 0.375 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.159596 | 0.797 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.321888 | 0.492 |
| R-HSA-68882 | Mitotic Anaphase | 0.075928 | 1.120 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.409211 | 0.388 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.418295 | 0.379 |
| R-HSA-2262752 | Cellular responses to stress | 0.054129 | 1.267 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.299459 | 0.524 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.077242 | 1.112 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.411023 | 0.386 |
| R-HSA-69206 | G1/S Transition | 0.173063 | 0.762 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.097332 | 1.012 |
| R-HSA-195721 | Signaling by WNT | 0.224251 | 0.649 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.200943 | 0.697 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.038090 | 1.419 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.142284 | 0.847 |
| R-HSA-194138 | Signaling by VEGF | 0.368029 | 0.434 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.367554 | 0.435 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.288903 | 0.539 |
| R-HSA-1989781 | PPARA activates gene expression | 0.132352 | 0.878 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.288527 | 0.540 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.108244 | 0.966 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.320824 | 0.494 |
| R-HSA-1221632 | Meiotic synapsis | 0.243332 | 0.614 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.390616 | 0.408 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.061908 | 1.208 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.345352 | 0.462 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.156679 | 0.805 |
| R-HSA-392518 | Signal amplification | 0.133055 | 0.876 |
| R-HSA-450294 | MAP kinase activation | 0.288903 | 0.539 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.380590 | 0.420 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.112653 | 0.948 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.381101 | 0.419 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.136930 | 0.864 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.381101 | 0.419 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.381101 | 0.419 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.284150 | 0.546 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.246848 | 0.608 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.359665 | 0.444 |
| R-HSA-68875 | Mitotic Prophase | 0.342893 | 0.465 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.123410 | 0.909 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.066170 | 1.179 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.078037 | 1.108 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.148860 | 0.827 |
| R-HSA-392517 | Rap1 signalling | 0.310224 | 0.508 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.409211 | 0.388 |
| R-HSA-448424 | Interleukin-17 signaling | 0.339760 | 0.469 |
| R-HSA-5688426 | Deubiquitination | 0.136817 | 0.864 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.217585 | 0.662 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.351660 | 0.454 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.361625 | 0.442 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.263345 | 0.579 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.238661 | 0.622 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.238661 | 0.622 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.238661 | 0.622 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.207095 | 0.684 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.266151 | 0.575 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.299459 | 0.524 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.361625 | 0.442 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.156679 | 0.805 |
| R-HSA-6807070 | PTEN Regulation | 0.096428 | 1.016 |
| R-HSA-70635 | Urea cycle | 0.390616 | 0.408 |
| R-HSA-4086400 | PCP/CE pathway | 0.384013 | 0.416 |
| R-HSA-69481 | G2/M Checkpoints | 0.376375 | 0.424 |
| R-HSA-112040 | G-protein mediated events | 0.322904 | 0.491 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.288329 | 0.540 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.112648 | 0.948 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.292513 | 0.534 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.338694 | 0.470 |
| R-HSA-3214842 | HDMs demethylate histones | 0.381101 | 0.419 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.292513 | 0.534 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.338694 | 0.470 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.351285 | 0.454 |
| R-HSA-8939211 | ESR-mediated signaling | 0.106300 | 0.973 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.271646 | 0.566 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.351285 | 0.454 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.042483 | 1.372 |
| R-HSA-9664420 | Killing mechanisms | 0.266151 | 0.575 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.266151 | 0.575 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.277425 | 0.557 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.399985 | 0.398 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.342269 | 0.466 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.305088 | 0.516 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.046163 | 1.336 |
| R-HSA-72306 | tRNA processing | 0.335305 | 0.475 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.317686 | 0.498 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.328625 | 0.483 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.031159 | 1.506 |
| R-HSA-111885 | Opioid Signalling | 0.263345 | 0.579 |
| R-HSA-2028269 | Signaling by Hippo | 0.288527 | 0.540 |
| R-HSA-9634597 | GPER1 signaling | 0.214990 | 0.668 |
| R-HSA-109581 | Apoptosis | 0.148676 | 0.828 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.263345 | 0.579 |
| R-HSA-4839726 | Chromatin organization | 0.239119 | 0.621 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.079312 | 1.101 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.079312 | 1.101 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.310224 | 0.508 |
| R-HSA-445144 | Signal transduction by L1 | 0.320824 | 0.494 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.421798 | 0.375 |
| R-HSA-5619084 | ABC transporter disorders | 0.384013 | 0.416 |
| R-HSA-73887 | Death Receptor Signaling | 0.130090 | 0.886 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.093183 | 1.031 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.198139 | 0.703 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.361625 | 0.442 |
| R-HSA-180024 | DARPP-32 events | 0.418295 | 0.379 |
| R-HSA-5357801 | Programmed Cell Death | 0.138238 | 0.859 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.356903 | 0.447 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.309285 | 0.510 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.190749 | 0.720 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.345352 | 0.462 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.001012 | 2.995 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.021747 | 1.663 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.421798 | 0.375 |
| R-HSA-418597 | G alpha (z) signalling events | 0.254719 | 0.594 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.243617 | 0.613 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.423772 | 0.373 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.125619 | 0.901 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.222439 | 0.653 |
| R-HSA-212436 | Generic Transcription Pathway | 0.390543 | 0.408 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.421665 | 0.375 |
| R-HSA-373755 | Semaphorin interactions | 0.300269 | 0.522 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.143549 | 0.843 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.351660 | 0.454 |
| R-HSA-1474165 | Reproduction | 0.191406 | 0.718 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.149387 | 0.826 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.114524 | 0.941 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.399985 | 0.398 |
| R-HSA-1500620 | Meiosis | 0.421665 | 0.375 |
| R-HSA-977225 | Amyloid fiber formation | 0.400286 | 0.398 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.114524 | 0.941 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.310224 | 0.508 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.105042 | 0.979 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.361625 | 0.442 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.332613 | 0.478 |
| R-HSA-9830364 | Formation of the nephric duct | 0.083859 | 1.076 |
| R-HSA-8964038 | LDL clearance | 0.351660 | 0.454 |
| R-HSA-421270 | Cell-cell junction organization | 0.408629 | 0.389 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.158276 | 0.801 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.192558 | 0.715 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.367554 | 0.435 |
| R-HSA-913531 | Interferon Signaling | 0.176793 | 0.753 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.335362 | 0.474 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.142208 | 0.847 |
| R-HSA-622312 | Inflammasomes | 0.409211 | 0.388 |
| R-HSA-9830369 | Kidney development | 0.322904 | 0.491 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.186872 | 0.728 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.427241 | 0.369 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.427241 | 0.369 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.427241 | 0.369 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.427241 | 0.369 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.427241 | 0.369 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.427241 | 0.369 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.427241 | 0.369 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.436049 | 0.360 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.436049 | 0.360 |
| R-HSA-182971 | EGFR downregulation | 0.436049 | 0.360 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.436049 | 0.360 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.436049 | 0.360 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.439243 | 0.357 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.439243 | 0.357 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.442649 | 0.354 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.444722 | 0.352 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.444722 | 0.352 |
| R-HSA-1538133 | G0 and Early G1 | 0.444722 | 0.352 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.452983 | 0.344 |
| R-HSA-202424 | Downstream TCR signaling | 0.452983 | 0.344 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.453263 | 0.344 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.453263 | 0.344 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.453263 | 0.344 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.453263 | 0.344 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.453263 | 0.344 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.453263 | 0.344 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.453263 | 0.344 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.453263 | 0.344 |
| R-HSA-72172 | mRNA Splicing | 0.456218 | 0.341 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.459795 | 0.337 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.461672 | 0.336 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.461672 | 0.336 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.461672 | 0.336 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.461672 | 0.336 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.461672 | 0.336 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.461672 | 0.336 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.461672 | 0.336 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.461672 | 0.336 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.468277 | 0.329 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.469953 | 0.328 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.469953 | 0.328 |
| R-HSA-203615 | eNOS activation | 0.469953 | 0.328 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.469953 | 0.328 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.469953 | 0.328 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.469953 | 0.328 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.469953 | 0.328 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.469953 | 0.328 |
| R-HSA-5205647 | Mitophagy | 0.469953 | 0.328 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.469953 | 0.328 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.473319 | 0.325 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.473960 | 0.324 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.478107 | 0.320 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.478107 | 0.320 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.478107 | 0.320 |
| R-HSA-169911 | Regulation of Apoptosis | 0.478107 | 0.320 |
| R-HSA-381042 | PERK regulates gene expression | 0.478107 | 0.320 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.478107 | 0.320 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.486136 | 0.313 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.486136 | 0.313 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.486136 | 0.313 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.486136 | 0.313 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.486136 | 0.313 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.486136 | 0.313 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.488269 | 0.311 |
| R-HSA-446728 | Cell junction organization | 0.489322 | 0.310 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.490752 | 0.309 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.492244 | 0.308 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.493194 | 0.307 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.493194 | 0.307 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.493194 | 0.307 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.494042 | 0.306 |
| R-HSA-4641258 | Degradation of DVL | 0.494042 | 0.306 |
| R-HSA-4641257 | Degradation of AXIN | 0.494042 | 0.306 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.494042 | 0.306 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.494042 | 0.306 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.494042 | 0.306 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.494042 | 0.306 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.494042 | 0.306 |
| R-HSA-157579 | Telomere Maintenance | 0.498089 | 0.303 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.500974 | 0.300 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.501827 | 0.299 |
| R-HSA-73927 | Depurination | 0.501827 | 0.299 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.501827 | 0.299 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.502108 | 0.299 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.502953 | 0.298 |
| R-HSA-3214847 | HATs acetylate histones | 0.507788 | 0.294 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.509492 | 0.293 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.509492 | 0.293 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.509492 | 0.293 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.509492 | 0.293 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.509492 | 0.293 |
| R-HSA-69541 | Stabilization of p53 | 0.509492 | 0.293 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.509492 | 0.293 |
| R-HSA-74160 | Gene expression (Transcription) | 0.511165 | 0.291 |
| R-HSA-8951664 | Neddylation | 0.512517 | 0.290 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.512591 | 0.290 |
| R-HSA-70171 | Glycolysis | 0.512591 | 0.290 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.517040 | 0.286 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.517040 | 0.286 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.517040 | 0.286 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.517040 | 0.286 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.517040 | 0.286 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.517040 | 0.286 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.517040 | 0.286 |
| R-HSA-5260271 | Diseases of Immune System | 0.517040 | 0.286 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.517040 | 0.286 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.517040 | 0.286 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.521117 | 0.283 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.522106 | 0.282 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.522106 | 0.282 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.524472 | 0.280 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.524472 | 0.280 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.524472 | 0.280 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.524472 | 0.280 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.524472 | 0.280 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.526816 | 0.278 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.531791 | 0.274 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.531791 | 0.274 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.531791 | 0.274 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.531791 | 0.274 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.531791 | 0.274 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.531791 | 0.274 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.531791 | 0.274 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.531791 | 0.274 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.531791 | 0.274 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.531791 | 0.274 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.538997 | 0.268 |
| R-HSA-165159 | MTOR signalling | 0.538997 | 0.268 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.538997 | 0.268 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.538997 | 0.268 |
| R-HSA-73928 | Depyrimidination | 0.538997 | 0.268 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.540910 | 0.267 |
| R-HSA-418346 | Platelet homeostasis | 0.545343 | 0.263 |
| R-HSA-9710421 | Defective pyroptosis | 0.546093 | 0.263 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.546093 | 0.263 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.546093 | 0.263 |
| R-HSA-69239 | Synthesis of DNA | 0.549896 | 0.260 |
| R-HSA-190828 | Gap junction trafficking | 0.553080 | 0.257 |
| R-HSA-9907900 | Proteasome assembly | 0.553080 | 0.257 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.553080 | 0.257 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.554416 | 0.256 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.554416 | 0.256 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.558905 | 0.253 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.559959 | 0.252 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.559959 | 0.252 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.559959 | 0.252 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.559959 | 0.252 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.559959 | 0.252 |
| R-HSA-9824272 | Somitogenesis | 0.559959 | 0.252 |
| R-HSA-202403 | TCR signaling | 0.563361 | 0.249 |
| R-HSA-418555 | G alpha (s) signalling events | 0.564041 | 0.249 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.566734 | 0.247 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.566734 | 0.247 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.566734 | 0.247 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.566734 | 0.247 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.566734 | 0.247 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.566734 | 0.247 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.566734 | 0.247 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.566734 | 0.247 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.566734 | 0.247 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.571119 | 0.243 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.571119 | 0.243 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.572177 | 0.242 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.573404 | 0.242 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.573404 | 0.242 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.579972 | 0.237 |
| R-HSA-70263 | Gluconeogenesis | 0.579972 | 0.237 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.579972 | 0.237 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.579972 | 0.237 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.586440 | 0.232 |
| R-HSA-9766229 | Degradation of CDH1 | 0.586440 | 0.232 |
| R-HSA-73893 | DNA Damage Bypass | 0.586440 | 0.232 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.586440 | 0.232 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.586440 | 0.232 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.586440 | 0.232 |
| R-HSA-199991 | Membrane Trafficking | 0.587833 | 0.231 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.592808 | 0.227 |
| R-HSA-1500931 | Cell-Cell communication | 0.595247 | 0.225 |
| R-HSA-2559583 | Cellular Senescence | 0.595328 | 0.225 |
| R-HSA-373760 | L1CAM interactions | 0.597846 | 0.223 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.599079 | 0.223 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.599079 | 0.223 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.599079 | 0.223 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.599079 | 0.223 |
| R-HSA-70326 | Glucose metabolism | 0.602011 | 0.220 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.605253 | 0.218 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.605253 | 0.218 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.606143 | 0.217 |
| R-HSA-6798695 | Neutrophil degranulation | 0.609757 | 0.215 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.610243 | 0.214 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.611333 | 0.214 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.611333 | 0.214 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.611333 | 0.214 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.611333 | 0.214 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.611333 | 0.214 |
| R-HSA-69275 | G2/M Transition | 0.615362 | 0.211 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.617319 | 0.209 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.617319 | 0.209 |
| R-HSA-73886 | Chromosome Maintenance | 0.618345 | 0.209 |
| R-HSA-3371556 | Cellular response to heat stress | 0.618345 | 0.209 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.621891 | 0.206 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.623214 | 0.205 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.623214 | 0.205 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.623214 | 0.205 |
| R-HSA-983712 | Ion channel transport | 0.625127 | 0.204 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.626317 | 0.203 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.626317 | 0.203 |
| R-HSA-177929 | Signaling by EGFR | 0.629018 | 0.201 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.631542 | 0.200 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.634733 | 0.197 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.634733 | 0.197 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.640360 | 0.194 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.640360 | 0.194 |
| R-HSA-191859 | snRNP Assembly | 0.645901 | 0.190 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.645901 | 0.190 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.645901 | 0.190 |
| R-HSA-9609690 | HCMV Early Events | 0.647248 | 0.189 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.647248 | 0.189 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.651357 | 0.186 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.651357 | 0.186 |
| R-HSA-379724 | tRNA Aminoacylation | 0.651357 | 0.186 |
| R-HSA-156590 | Glutathione conjugation | 0.651357 | 0.186 |
| R-HSA-351202 | Metabolism of polyamines | 0.651357 | 0.186 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.651357 | 0.186 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.656729 | 0.183 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.656729 | 0.183 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.656920 | 0.182 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.662019 | 0.179 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.662019 | 0.179 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.662019 | 0.179 |
| R-HSA-1268020 | Mitochondrial protein import | 0.662019 | 0.179 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.662019 | 0.179 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.667228 | 0.176 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.667228 | 0.176 |
| R-HSA-8848021 | Signaling by PTK6 | 0.667228 | 0.176 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.667228 | 0.176 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.667791 | 0.175 |
| R-HSA-449147 | Signaling by Interleukins | 0.670556 | 0.174 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.672357 | 0.172 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.677406 | 0.169 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.682379 | 0.166 |
| R-HSA-163685 | Integration of energy metabolism | 0.685493 | 0.164 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.685570 | 0.164 |
| R-HSA-9658195 | Leishmania infection | 0.685570 | 0.164 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.687275 | 0.163 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.688924 | 0.162 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.692096 | 0.160 |
| R-HSA-5218859 | Regulated Necrosis | 0.692096 | 0.160 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.692325 | 0.160 |
| R-HSA-5368287 | Mitochondrial translation | 0.692325 | 0.160 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.692325 | 0.160 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.697067 | 0.157 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.701517 | 0.154 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.701517 | 0.154 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.701517 | 0.154 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.701517 | 0.154 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.706119 | 0.151 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.706119 | 0.151 |
| R-HSA-8978934 | Metabolism of cofactors | 0.706119 | 0.151 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.708873 | 0.149 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.708873 | 0.149 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.710650 | 0.148 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.710650 | 0.148 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.710650 | 0.148 |
| R-HSA-418990 | Adherens junctions interactions | 0.713333 | 0.147 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.715112 | 0.146 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.715112 | 0.146 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.715112 | 0.146 |
| R-HSA-4086398 | Ca2+ pathway | 0.715112 | 0.146 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.719506 | 0.143 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.719506 | 0.143 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.719506 | 0.143 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.723832 | 0.140 |
| R-HSA-8852135 | Protein ubiquitination | 0.723832 | 0.140 |
| R-HSA-69242 | S Phase | 0.727747 | 0.138 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.728091 | 0.138 |
| R-HSA-9758941 | Gastrulation | 0.730790 | 0.136 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.732285 | 0.135 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.736415 | 0.133 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.736415 | 0.133 |
| R-HSA-162906 | HIV Infection | 0.736463 | 0.133 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.738940 | 0.131 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.739106 | 0.131 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.739747 | 0.131 |
| R-HSA-9833482 | PKR-mediated signaling | 0.744484 | 0.128 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.745577 | 0.128 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.748427 | 0.126 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.748427 | 0.126 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.748450 | 0.126 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.750155 | 0.125 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.752308 | 0.124 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.752308 | 0.124 |
| R-HSA-162587 | HIV Life Cycle | 0.754112 | 0.123 |
| R-HSA-9711097 | Cellular response to starvation | 0.756902 | 0.121 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.762401 | 0.118 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.763599 | 0.117 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.764389 | 0.117 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.767247 | 0.115 |
| R-HSA-157118 | Signaling by NOTCH | 0.767248 | 0.115 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.770839 | 0.113 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.770839 | 0.113 |
| R-HSA-162582 | Signal Transduction | 0.771634 | 0.113 |
| R-HSA-1280218 | Adaptive Immune System | 0.773019 | 0.112 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.773075 | 0.112 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.774376 | 0.111 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.774376 | 0.111 |
| R-HSA-422475 | Axon guidance | 0.774544 | 0.111 |
| R-HSA-156902 | Peptide chain elongation | 0.777859 | 0.109 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.778122 | 0.109 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.781288 | 0.107 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.782580 | 0.106 |
| R-HSA-73884 | Base Excision Repair | 0.784664 | 0.105 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.787989 | 0.103 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.787989 | 0.103 |
| R-HSA-9609646 | HCMV Infection | 0.788893 | 0.103 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.791262 | 0.102 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.793179 | 0.101 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.794485 | 0.100 |
| R-HSA-391251 | Protein folding | 0.794485 | 0.100 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.794485 | 0.100 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.797953 | 0.098 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.797953 | 0.098 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.800783 | 0.096 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.800783 | 0.096 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.802631 | 0.095 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.803860 | 0.095 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.806889 | 0.093 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.806889 | 0.093 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.806889 | 0.093 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.809872 | 0.092 |
| R-HSA-168255 | Influenza Infection | 0.811698 | 0.091 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.812809 | 0.090 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.812809 | 0.090 |
| R-HSA-422356 | Regulation of insulin secretion | 0.815700 | 0.088 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.818548 | 0.087 |
| R-HSA-597592 | Post-translational protein modification | 0.822571 | 0.085 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.824111 | 0.084 |
| R-HSA-9675108 | Nervous system development | 0.826318 | 0.083 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.826829 | 0.083 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.826829 | 0.083 |
| R-HSA-1483255 | PI Metabolism | 0.826829 | 0.083 |
| R-HSA-72766 | Translation | 0.827051 | 0.082 |
| R-HSA-192823 | Viral mRNA Translation | 0.829505 | 0.081 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.832139 | 0.080 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.834733 | 0.078 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.834733 | 0.078 |
| R-HSA-9833110 | RSV-host interactions | 0.834733 | 0.078 |
| R-HSA-5617833 | Cilium Assembly | 0.834751 | 0.078 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.839802 | 0.076 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.842279 | 0.075 |
| R-HSA-211000 | Gene Silencing by RNA | 0.842279 | 0.075 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.844717 | 0.073 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.844717 | 0.073 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.844717 | 0.073 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.846405 | 0.072 |
| R-HSA-6803157 | Antimicrobial peptides | 0.851808 | 0.070 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.854099 | 0.068 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.854099 | 0.068 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.854099 | 0.068 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.856355 | 0.067 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.856976 | 0.067 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.858699 | 0.066 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.858699 | 0.066 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.861317 | 0.065 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.862917 | 0.064 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.867124 | 0.062 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.867124 | 0.062 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.869180 | 0.061 |
| R-HSA-397014 | Muscle contraction | 0.874922 | 0.058 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.876447 | 0.057 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.880864 | 0.055 |
| R-HSA-114608 | Platelet degranulation | 0.889802 | 0.051 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.891508 | 0.050 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.897905 | 0.047 |
| R-HSA-5576891 | Cardiac conduction | 0.898072 | 0.047 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.898625 | 0.046 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.899651 | 0.046 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.899881 | 0.046 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.901181 | 0.045 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.901205 | 0.045 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.919354 | 0.037 |
| R-HSA-2187338 | Visual phototransduction | 0.923046 | 0.035 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.923046 | 0.035 |
| R-HSA-166520 | Signaling by NTRKs | 0.924239 | 0.034 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.925846 | 0.033 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.926570 | 0.033 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.926570 | 0.033 |
| R-HSA-388396 | GPCR downstream signalling | 0.927609 | 0.033 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.929064 | 0.032 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.929933 | 0.032 |
| R-HSA-9609507 | Protein localization | 0.929933 | 0.032 |
| R-HSA-168256 | Immune System | 0.930207 | 0.031 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.932169 | 0.031 |
| R-HSA-109582 | Hemostasis | 0.933244 | 0.030 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.934028 | 0.030 |
| R-HSA-9610379 | HCMV Late Events | 0.934180 | 0.030 |
| R-HSA-73894 | DNA Repair | 0.934478 | 0.029 |
| R-HSA-416476 | G alpha (q) signalling events | 0.934867 | 0.029 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.935201 | 0.029 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.937196 | 0.028 |
| R-HSA-5619102 | SLC transporter disorders | 0.943708 | 0.025 |
| R-HSA-112316 | Neuronal System | 0.945793 | 0.024 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.947123 | 0.024 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.949548 | 0.022 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.951103 | 0.022 |
| R-HSA-1483257 | Phospholipid metabolism | 0.956400 | 0.019 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.960108 | 0.018 |
| R-HSA-168249 | Innate Immune System | 0.960713 | 0.017 |
| R-HSA-418594 | G alpha (i) signalling events | 0.962356 | 0.017 |
| R-HSA-372790 | Signaling by GPCR | 0.964003 | 0.016 |
| R-HSA-392499 | Metabolism of proteins | 0.966845 | 0.015 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.968465 | 0.014 |
| R-HSA-8957322 | Metabolism of steroids | 0.970255 | 0.013 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.976294 | 0.010 |
| R-HSA-9679506 | SARS-CoV Infections | 0.978997 | 0.009 |
| R-HSA-72312 | rRNA processing | 0.980307 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.981506 | 0.008 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.982358 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 0.985271 | 0.006 |
| R-HSA-1266738 | Developmental Biology | 0.986749 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.988530 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.992259 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.998045 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.999111 | 0.000 |
| R-HSA-1643685 | Disease | 0.999749 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999808 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999957 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.858 | 0.707 | 1 | 0.908 |
P38G |
0.855 | 0.748 | 1 | 0.938 |
KIS |
0.855 | 0.633 | 1 | 0.878 |
CDK18 |
0.855 | 0.713 | 1 | 0.922 |
CDK8 |
0.854 | 0.708 | 1 | 0.887 |
JNK2 |
0.854 | 0.760 | 1 | 0.919 |
CDK17 |
0.852 | 0.724 | 1 | 0.933 |
HIPK2 |
0.852 | 0.656 | 1 | 0.920 |
CDK7 |
0.850 | 0.691 | 1 | 0.896 |
CDK3 |
0.849 | 0.650 | 1 | 0.932 |
P38D |
0.849 | 0.735 | 1 | 0.944 |
P38B |
0.849 | 0.730 | 1 | 0.901 |
ERK1 |
0.847 | 0.707 | 1 | 0.911 |
CDK13 |
0.847 | 0.702 | 1 | 0.911 |
CDK5 |
0.847 | 0.682 | 1 | 0.876 |
CDK1 |
0.846 | 0.696 | 1 | 0.910 |
DYRK2 |
0.846 | 0.655 | 1 | 0.868 |
CDK16 |
0.846 | 0.701 | 1 | 0.928 |
JNK3 |
0.845 | 0.743 | 1 | 0.910 |
CDK12 |
0.844 | 0.701 | 1 | 0.923 |
DYRK4 |
0.842 | 0.669 | 1 | 0.929 |
P38A |
0.842 | 0.705 | 1 | 0.857 |
CLK3 |
0.839 | 0.454 | 1 | 0.659 |
CDK9 |
0.839 | 0.686 | 1 | 0.907 |
HIPK4 |
0.837 | 0.419 | 1 | 0.695 |
CDK14 |
0.835 | 0.681 | 1 | 0.896 |
HIPK1 |
0.835 | 0.594 | 1 | 0.851 |
NLK |
0.835 | 0.616 | 1 | 0.696 |
CDK10 |
0.834 | 0.642 | 1 | 0.908 |
DYRK1B |
0.833 | 0.628 | 1 | 0.900 |
ERK2 |
0.833 | 0.691 | 1 | 0.884 |
SRPK1 |
0.831 | 0.316 | -3 | 0.736 |
HIPK3 |
0.828 | 0.577 | 1 | 0.825 |
DYRK1A |
0.828 | 0.527 | 1 | 0.834 |
ERK5 |
0.827 | 0.354 | 1 | 0.618 |
CDK4 |
0.825 | 0.679 | 1 | 0.927 |
CDK6 |
0.824 | 0.655 | 1 | 0.906 |
JNK1 |
0.823 | 0.662 | 1 | 0.919 |
CDK2 |
0.823 | 0.539 | 1 | 0.820 |
FAM20C |
0.822 | 0.389 | 2 | 0.914 |
DYRK3 |
0.818 | 0.470 | 1 | 0.823 |
CDKL5 |
0.817 | 0.165 | -3 | 0.778 |
SRPK2 |
0.817 | 0.246 | -3 | 0.665 |
CLK1 |
0.816 | 0.348 | -3 | 0.747 |
ICK |
0.815 | 0.318 | -3 | 0.817 |
CLK2 |
0.815 | 0.363 | -3 | 0.740 |
MTOR |
0.814 | 0.164 | 1 | 0.503 |
CDKL1 |
0.812 | 0.138 | -3 | 0.785 |
COT |
0.811 | -0.059 | 2 | 0.705 |
MAK |
0.810 | 0.444 | -2 | 0.775 |
CLK4 |
0.810 | 0.313 | -3 | 0.758 |
SRPK3 |
0.808 | 0.220 | -3 | 0.704 |
PRPK |
0.806 | -0.029 | -1 | 0.835 |
ERK7 |
0.806 | 0.240 | 2 | 0.470 |
MOK |
0.805 | 0.420 | 1 | 0.764 |
PRP4 |
0.804 | 0.402 | -3 | 0.767 |
MOS |
0.804 | -0.023 | 1 | 0.401 |
CDC7 |
0.803 | -0.098 | 1 | 0.351 |
PRKD1 |
0.802 | 0.012 | -3 | 0.814 |
DSTYK |
0.802 | -0.044 | 2 | 0.753 |
PDHK4 |
0.801 | -0.039 | 1 | 0.408 |
TBK1 |
0.801 | -0.125 | 1 | 0.298 |
ATR |
0.800 | -0.021 | 1 | 0.395 |
PKN3 |
0.799 | -0.028 | -3 | 0.811 |
CAMK1B |
0.798 | -0.023 | -3 | 0.845 |
PIM3 |
0.798 | -0.037 | -3 | 0.808 |
WNK1 |
0.798 | -0.049 | -2 | 0.870 |
NUAK2 |
0.798 | 0.004 | -3 | 0.827 |
NEK6 |
0.798 | -0.079 | -2 | 0.861 |
NDR2 |
0.797 | -0.043 | -3 | 0.808 |
GCN2 |
0.797 | -0.200 | 2 | 0.639 |
ULK2 |
0.797 | -0.180 | 2 | 0.621 |
MST4 |
0.796 | -0.047 | 2 | 0.698 |
PRKD2 |
0.796 | 0.006 | -3 | 0.773 |
BMPR2 |
0.796 | -0.115 | -2 | 0.877 |
CAMK2G |
0.796 | -0.027 | 2 | 0.700 |
IKKE |
0.796 | -0.143 | 1 | 0.294 |
PDHK1 |
0.794 | -0.135 | 1 | 0.380 |
CAMK2D |
0.794 | 0.010 | -3 | 0.827 |
SKMLCK |
0.794 | -0.018 | -2 | 0.840 |
RSK2 |
0.793 | -0.004 | -3 | 0.764 |
RSK3 |
0.793 | -0.020 | -3 | 0.764 |
P90RSK |
0.793 | -0.004 | -3 | 0.766 |
RAF1 |
0.793 | -0.196 | 1 | 0.340 |
PKCD |
0.792 | -0.038 | 2 | 0.626 |
NIK |
0.792 | -0.072 | -3 | 0.858 |
IKKB |
0.792 | -0.147 | -2 | 0.727 |
CHAK2 |
0.792 | -0.076 | -1 | 0.816 |
MAPKAPK3 |
0.791 | -0.030 | -3 | 0.771 |
NEK7 |
0.791 | -0.168 | -3 | 0.828 |
PIM1 |
0.791 | 0.017 | -3 | 0.765 |
NDR1 |
0.790 | -0.076 | -3 | 0.813 |
CAMLCK |
0.790 | -0.027 | -2 | 0.820 |
TGFBR2 |
0.790 | -0.104 | -2 | 0.776 |
RIPK3 |
0.790 | -0.131 | 3 | 0.778 |
MARK4 |
0.790 | -0.045 | 4 | 0.833 |
PKN2 |
0.789 | -0.080 | -3 | 0.819 |
MAPKAPK2 |
0.789 | 0.009 | -3 | 0.724 |
MLK1 |
0.789 | -0.150 | 2 | 0.658 |
ATM |
0.788 | -0.015 | 1 | 0.352 |
ULK1 |
0.788 | -0.167 | -3 | 0.804 |
DNAPK |
0.788 | 0.033 | 1 | 0.355 |
LATS2 |
0.787 | -0.040 | -5 | 0.767 |
MLK3 |
0.787 | -0.065 | 2 | 0.604 |
IRE1 |
0.787 | -0.101 | 1 | 0.349 |
DAPK2 |
0.786 | -0.059 | -3 | 0.848 |
HUNK |
0.786 | -0.152 | 2 | 0.632 |
CAMK2B |
0.786 | 0.050 | 2 | 0.737 |
NEK9 |
0.786 | -0.164 | 2 | 0.662 |
MLK2 |
0.786 | -0.123 | 2 | 0.657 |
PRKD3 |
0.786 | -0.007 | -3 | 0.746 |
BCKDK |
0.786 | -0.133 | -1 | 0.753 |
PKCB |
0.785 | -0.038 | 2 | 0.588 |
TSSK2 |
0.785 | -0.058 | -5 | 0.848 |
LATS1 |
0.785 | 0.052 | -3 | 0.819 |
PHKG1 |
0.784 | -0.071 | -3 | 0.808 |
TSSK1 |
0.784 | -0.052 | -3 | 0.853 |
AMPKA1 |
0.784 | -0.090 | -3 | 0.835 |
P70S6KB |
0.784 | -0.034 | -3 | 0.784 |
MNK2 |
0.783 | -0.044 | -2 | 0.770 |
WNK3 |
0.783 | -0.211 | 1 | 0.343 |
NUAK1 |
0.783 | -0.044 | -3 | 0.784 |
BMPR1B |
0.782 | -0.024 | 1 | 0.307 |
IRE2 |
0.782 | -0.090 | 2 | 0.575 |
PKCA |
0.782 | -0.046 | 2 | 0.582 |
SMG1 |
0.782 | -0.038 | 1 | 0.374 |
PKCG |
0.781 | -0.058 | 2 | 0.585 |
NIM1 |
0.781 | -0.101 | 3 | 0.792 |
MASTL |
0.781 | -0.189 | -2 | 0.805 |
IKKA |
0.781 | -0.090 | -2 | 0.732 |
CAMK2A |
0.781 | 0.011 | 2 | 0.700 |
PKR |
0.781 | -0.077 | 1 | 0.371 |
AURC |
0.781 | -0.028 | -2 | 0.625 |
AMPKA2 |
0.780 | -0.067 | -3 | 0.806 |
TGFBR1 |
0.780 | -0.028 | -2 | 0.777 |
GRK5 |
0.779 | -0.186 | -3 | 0.802 |
PKCZ |
0.779 | -0.065 | 2 | 0.617 |
GRK1 |
0.779 | -0.050 | -2 | 0.760 |
PKACG |
0.779 | -0.063 | -2 | 0.711 |
NEK2 |
0.778 | -0.123 | 2 | 0.641 |
RIPK1 |
0.778 | -0.187 | 1 | 0.343 |
PINK1 |
0.778 | 0.114 | 1 | 0.540 |
PAK3 |
0.777 | -0.099 | -2 | 0.744 |
MNK1 |
0.777 | -0.045 | -2 | 0.779 |
PAK6 |
0.777 | -0.038 | -2 | 0.657 |
TTBK2 |
0.777 | -0.201 | 2 | 0.562 |
ANKRD3 |
0.777 | -0.206 | 1 | 0.364 |
ALK4 |
0.777 | -0.074 | -2 | 0.800 |
VRK2 |
0.777 | -0.037 | 1 | 0.448 |
GRK6 |
0.776 | -0.121 | 1 | 0.336 |
PKCH |
0.776 | -0.076 | 2 | 0.572 |
PAK1 |
0.776 | -0.080 | -2 | 0.749 |
RSK4 |
0.776 | -0.012 | -3 | 0.727 |
MLK4 |
0.775 | -0.110 | 2 | 0.594 |
MELK |
0.775 | -0.103 | -3 | 0.797 |
AKT2 |
0.775 | 0.006 | -3 | 0.687 |
DLK |
0.775 | -0.232 | 1 | 0.348 |
MPSK1 |
0.774 | 0.019 | 1 | 0.400 |
QSK |
0.774 | -0.059 | 4 | 0.819 |
GRK7 |
0.774 | -0.020 | 1 | 0.355 |
CHAK1 |
0.774 | -0.157 | 2 | 0.601 |
MSK2 |
0.774 | -0.055 | -3 | 0.727 |
SGK3 |
0.774 | -0.034 | -3 | 0.753 |
YSK4 |
0.773 | -0.166 | 1 | 0.311 |
PLK3 |
0.773 | -0.054 | 2 | 0.646 |
MAPKAPK5 |
0.773 | -0.056 | -3 | 0.717 |
PIM2 |
0.773 | 0.005 | -3 | 0.741 |
CAMK4 |
0.773 | -0.139 | -3 | 0.804 |
QIK |
0.773 | -0.121 | -3 | 0.817 |
PLK1 |
0.772 | -0.130 | -2 | 0.802 |
ALK2 |
0.772 | -0.027 | -2 | 0.780 |
MEK1 |
0.771 | -0.157 | 2 | 0.677 |
PKG2 |
0.771 | -0.043 | -2 | 0.648 |
PKACB |
0.771 | -0.017 | -2 | 0.643 |
ACVR2A |
0.770 | -0.077 | -2 | 0.775 |
PHKG2 |
0.770 | -0.076 | -3 | 0.792 |
SIK |
0.770 | -0.070 | -3 | 0.750 |
PKCT |
0.769 | -0.068 | 2 | 0.577 |
PLK4 |
0.769 | -0.139 | 2 | 0.478 |
MSK1 |
0.769 | -0.033 | -3 | 0.733 |
AURB |
0.769 | -0.055 | -2 | 0.618 |
BRSK1 |
0.769 | -0.075 | -3 | 0.783 |
BRSK2 |
0.769 | -0.105 | -3 | 0.807 |
ACVR2B |
0.769 | -0.085 | -2 | 0.783 |
DCAMKL1 |
0.769 | -0.062 | -3 | 0.782 |
WNK4 |
0.769 | -0.112 | -2 | 0.862 |
CHK1 |
0.768 | -0.064 | -3 | 0.821 |
GRK4 |
0.768 | -0.187 | -2 | 0.805 |
GSK3A |
0.768 | 0.144 | 4 | 0.404 |
MARK3 |
0.767 | -0.054 | 4 | 0.774 |
MARK2 |
0.767 | -0.054 | 4 | 0.736 |
TLK2 |
0.767 | -0.142 | 1 | 0.334 |
MYLK4 |
0.767 | -0.060 | -2 | 0.730 |
CAMK1G |
0.766 | -0.071 | -3 | 0.754 |
IRAK4 |
0.766 | -0.141 | 1 | 0.330 |
PKCI |
0.766 | -0.050 | 2 | 0.597 |
HRI |
0.765 | -0.169 | -2 | 0.839 |
SSTK |
0.765 | -0.051 | 4 | 0.821 |
PERK |
0.765 | -0.170 | -2 | 0.815 |
NEK5 |
0.765 | -0.150 | 1 | 0.348 |
MST3 |
0.765 | -0.084 | 2 | 0.662 |
PAK2 |
0.765 | -0.119 | -2 | 0.727 |
MEKK2 |
0.765 | -0.135 | 2 | 0.638 |
MEKK1 |
0.764 | -0.175 | 1 | 0.344 |
SNRK |
0.764 | -0.180 | 2 | 0.507 |
DCAMKL2 |
0.764 | -0.070 | -3 | 0.808 |
MEK5 |
0.764 | -0.191 | 2 | 0.656 |
BMPR1A |
0.763 | -0.047 | 1 | 0.290 |
AKT1 |
0.763 | -0.021 | -3 | 0.704 |
ZAK |
0.762 | -0.177 | 1 | 0.317 |
PRKX |
0.762 | -0.003 | -3 | 0.670 |
DRAK1 |
0.762 | -0.163 | 1 | 0.308 |
MARK1 |
0.762 | -0.076 | 4 | 0.797 |
PKCE |
0.761 | -0.027 | 2 | 0.575 |
BRAF |
0.761 | -0.125 | -4 | 0.860 |
PKN1 |
0.761 | -0.042 | -3 | 0.727 |
TAO3 |
0.760 | -0.087 | 1 | 0.361 |
AURA |
0.760 | -0.059 | -2 | 0.587 |
SMMLCK |
0.760 | -0.053 | -3 | 0.803 |
TLK1 |
0.759 | -0.157 | -2 | 0.820 |
LKB1 |
0.758 | -0.060 | -3 | 0.826 |
MEKK3 |
0.758 | -0.200 | 1 | 0.341 |
P70S6K |
0.758 | -0.056 | -3 | 0.704 |
TAO2 |
0.757 | -0.085 | 2 | 0.674 |
PKACA |
0.757 | -0.026 | -2 | 0.596 |
GRK2 |
0.757 | -0.106 | -2 | 0.691 |
NEK11 |
0.757 | -0.155 | 1 | 0.353 |
NEK4 |
0.755 | -0.136 | 1 | 0.323 |
PAK5 |
0.755 | -0.077 | -2 | 0.600 |
MEKK6 |
0.755 | -0.114 | 1 | 0.337 |
PDK1 |
0.755 | -0.091 | 1 | 0.380 |
HGK |
0.755 | -0.074 | 3 | 0.859 |
TNIK |
0.755 | -0.048 | 3 | 0.861 |
GAK |
0.755 | -0.061 | 1 | 0.391 |
CAMK1D |
0.755 | -0.038 | -3 | 0.692 |
SBK |
0.754 | 0.095 | -3 | 0.583 |
PAK4 |
0.754 | -0.066 | -2 | 0.609 |
TTBK1 |
0.754 | -0.172 | 2 | 0.490 |
GSK3B |
0.754 | 0.012 | 4 | 0.396 |
PASK |
0.754 | -0.073 | -3 | 0.819 |
AKT3 |
0.753 | -0.007 | -3 | 0.627 |
NEK8 |
0.753 | -0.188 | 2 | 0.636 |
BUB1 |
0.753 | -0.006 | -5 | 0.781 |
CK2A2 |
0.753 | -0.010 | 1 | 0.277 |
MAP3K15 |
0.752 | -0.125 | 1 | 0.328 |
IRAK1 |
0.752 | -0.182 | -1 | 0.722 |
MINK |
0.751 | -0.105 | 1 | 0.317 |
CAMKK2 |
0.751 | -0.135 | -2 | 0.755 |
CK1E |
0.751 | -0.073 | -3 | 0.481 |
CAMKK1 |
0.750 | -0.178 | -2 | 0.757 |
EEF2K |
0.750 | -0.090 | 3 | 0.827 |
GCK |
0.750 | -0.105 | 1 | 0.339 |
SGK1 |
0.750 | 0.007 | -3 | 0.609 |
NEK1 |
0.749 | -0.141 | 1 | 0.325 |
LOK |
0.749 | -0.101 | -2 | 0.760 |
LRRK2 |
0.749 | -0.079 | 2 | 0.670 |
PBK |
0.749 | -0.045 | 1 | 0.360 |
HPK1 |
0.748 | -0.092 | 1 | 0.337 |
KHS1 |
0.748 | -0.063 | 1 | 0.333 |
DAPK3 |
0.747 | -0.059 | -3 | 0.784 |
CHK2 |
0.747 | -0.040 | -3 | 0.645 |
PLK2 |
0.747 | -0.023 | -3 | 0.821 |
HASPIN |
0.747 | -0.004 | -1 | 0.675 |
NEK3 |
0.746 | -0.100 | 1 | 0.336 |
KHS2 |
0.746 | -0.040 | 1 | 0.344 |
MRCKB |
0.746 | -0.037 | -3 | 0.730 |
MST2 |
0.746 | -0.165 | 1 | 0.328 |
CAMK1A |
0.744 | -0.043 | -3 | 0.659 |
YSK1 |
0.744 | -0.127 | 2 | 0.642 |
CK2A1 |
0.743 | -0.019 | 1 | 0.264 |
CK1D |
0.743 | -0.050 | -3 | 0.423 |
ROCK2 |
0.743 | -0.044 | -3 | 0.773 |
BIKE |
0.742 | -0.013 | 1 | 0.357 |
VRK1 |
0.741 | -0.198 | 2 | 0.640 |
CK1G1 |
0.740 | -0.111 | -3 | 0.464 |
STK33 |
0.740 | -0.149 | 2 | 0.487 |
SLK |
0.740 | -0.111 | -2 | 0.709 |
PDHK3_TYR |
0.740 | 0.104 | 4 | 0.884 |
GRK3 |
0.740 | -0.111 | -2 | 0.640 |
MRCKA |
0.739 | -0.061 | -3 | 0.746 |
DMPK1 |
0.739 | -0.004 | -3 | 0.754 |
RIPK2 |
0.739 | -0.210 | 1 | 0.298 |
TAK1 |
0.739 | -0.218 | 1 | 0.323 |
DAPK1 |
0.738 | -0.072 | -3 | 0.765 |
MEK2 |
0.738 | -0.205 | 2 | 0.641 |
MST1 |
0.737 | -0.187 | 1 | 0.319 |
AAK1 |
0.737 | 0.018 | 1 | 0.339 |
CK1A2 |
0.736 | -0.080 | -3 | 0.426 |
PKG1 |
0.736 | -0.061 | -2 | 0.562 |
LIMK2_TYR |
0.736 | 0.083 | -3 | 0.870 |
TESK1_TYR |
0.734 | 0.015 | 3 | 0.875 |
MYO3B |
0.733 | -0.084 | 2 | 0.652 |
CRIK |
0.733 | -0.011 | -3 | 0.700 |
PKMYT1_TYR |
0.732 | 0.056 | 3 | 0.858 |
OSR1 |
0.732 | -0.118 | 2 | 0.640 |
TTK |
0.731 | -0.093 | -2 | 0.817 |
ROCK1 |
0.731 | -0.051 | -3 | 0.745 |
TAO1 |
0.731 | -0.106 | 1 | 0.319 |
ASK1 |
0.730 | -0.137 | 1 | 0.324 |
MAP2K4_TYR |
0.729 | -0.020 | -1 | 0.845 |
PDHK4_TYR |
0.729 | 0.023 | 2 | 0.708 |
MAP2K6_TYR |
0.728 | 0.023 | -1 | 0.845 |
MAP2K7_TYR |
0.728 | -0.096 | 2 | 0.688 |
MYO3A |
0.727 | -0.113 | 1 | 0.342 |
BMPR2_TYR |
0.726 | 0.014 | -1 | 0.831 |
EPHA6 |
0.726 | -0.040 | -1 | 0.819 |
RET |
0.725 | -0.097 | 1 | 0.361 |
PINK1_TYR |
0.724 | -0.140 | 1 | 0.401 |
MST1R |
0.723 | -0.093 | 3 | 0.839 |
LIMK1_TYR |
0.723 | -0.047 | 2 | 0.682 |
PDHK1_TYR |
0.722 | -0.070 | -1 | 0.847 |
JAK2 |
0.722 | -0.096 | 1 | 0.361 |
ALPHAK3 |
0.721 | -0.061 | -1 | 0.742 |
CSF1R |
0.721 | -0.065 | 3 | 0.830 |
TYK2 |
0.721 | -0.166 | 1 | 0.347 |
ROS1 |
0.720 | -0.123 | 3 | 0.808 |
ABL2 |
0.719 | -0.071 | -1 | 0.777 |
TYRO3 |
0.718 | -0.133 | 3 | 0.826 |
TNNI3K_TYR |
0.718 | -0.040 | 1 | 0.376 |
EPHB4 |
0.718 | -0.096 | -1 | 0.789 |
YES1 |
0.717 | -0.053 | -1 | 0.811 |
DDR1 |
0.717 | -0.077 | 4 | 0.817 |
LCK |
0.717 | -0.049 | -1 | 0.803 |
JAK1 |
0.716 | -0.082 | 1 | 0.325 |
JAK3 |
0.716 | -0.106 | 1 | 0.352 |
FGFR2 |
0.716 | -0.007 | 3 | 0.811 |
YANK3 |
0.716 | -0.090 | 2 | 0.335 |
NEK10_TYR |
0.715 | -0.104 | 1 | 0.314 |
HCK |
0.714 | -0.083 | -1 | 0.802 |
TXK |
0.714 | -0.066 | 1 | 0.311 |
TNK1 |
0.714 | -0.083 | 3 | 0.809 |
ABL1 |
0.714 | -0.095 | -1 | 0.770 |
TEK |
0.714 | -0.006 | 3 | 0.772 |
BLK |
0.714 | -0.042 | -1 | 0.804 |
FGFR1 |
0.713 | -0.027 | 3 | 0.799 |
FGR |
0.713 | -0.135 | 1 | 0.336 |
TNK2 |
0.713 | -0.099 | 3 | 0.794 |
STLK3 |
0.712 | -0.195 | 1 | 0.299 |
INSRR |
0.712 | -0.080 | 3 | 0.780 |
EPHA4 |
0.711 | -0.056 | 2 | 0.651 |
FLT3 |
0.710 | -0.134 | 3 | 0.825 |
KDR |
0.710 | -0.092 | 3 | 0.797 |
KIT |
0.709 | -0.105 | 3 | 0.825 |
FER |
0.709 | -0.140 | 1 | 0.343 |
PDGFRB |
0.708 | -0.170 | 3 | 0.831 |
SRMS |
0.708 | -0.104 | 1 | 0.316 |
ITK |
0.708 | -0.124 | -1 | 0.768 |
AXL |
0.706 | -0.126 | 3 | 0.810 |
MERTK |
0.706 | -0.113 | 3 | 0.805 |
DDR2 |
0.705 | -0.001 | 3 | 0.769 |
EPHB1 |
0.705 | -0.144 | 1 | 0.319 |
FYN |
0.705 | -0.035 | -1 | 0.781 |
EPHB3 |
0.705 | -0.130 | -1 | 0.774 |
EPHB2 |
0.704 | -0.113 | -1 | 0.763 |
FGFR3 |
0.704 | -0.040 | 3 | 0.790 |
PDGFRA |
0.704 | -0.190 | 3 | 0.829 |
BTK |
0.703 | -0.152 | -1 | 0.742 |
MET |
0.702 | -0.119 | 3 | 0.816 |
WEE1_TYR |
0.702 | -0.099 | -1 | 0.716 |
EPHA7 |
0.702 | -0.087 | 2 | 0.645 |
BMX |
0.702 | -0.101 | -1 | 0.698 |
TEC |
0.702 | -0.128 | -1 | 0.714 |
EPHA1 |
0.701 | -0.111 | 3 | 0.804 |
ALK |
0.701 | -0.141 | 3 | 0.757 |
LTK |
0.701 | -0.130 | 3 | 0.775 |
LYN |
0.700 | -0.072 | 3 | 0.757 |
INSR |
0.700 | -0.106 | 3 | 0.763 |
FRK |
0.699 | -0.133 | -1 | 0.810 |
ERBB2 |
0.698 | -0.135 | 1 | 0.322 |
EGFR |
0.697 | -0.064 | 1 | 0.278 |
CK1A |
0.697 | -0.103 | -3 | 0.330 |
EPHA3 |
0.697 | -0.114 | 2 | 0.617 |
PTK2B |
0.697 | -0.089 | -1 | 0.747 |
FLT4 |
0.696 | -0.142 | 3 | 0.778 |
NTRK1 |
0.696 | -0.170 | -1 | 0.770 |
FLT1 |
0.695 | -0.145 | -1 | 0.777 |
SRC |
0.694 | -0.086 | -1 | 0.773 |
NTRK2 |
0.694 | -0.189 | 3 | 0.782 |
EPHA8 |
0.693 | -0.084 | -1 | 0.753 |
EPHA5 |
0.693 | -0.085 | 2 | 0.646 |
NTRK3 |
0.693 | -0.131 | -1 | 0.727 |
PTK2 |
0.692 | -0.043 | -1 | 0.749 |
PTK6 |
0.692 | -0.219 | -1 | 0.696 |
FGFR4 |
0.690 | -0.073 | -1 | 0.719 |
CSK |
0.689 | -0.119 | 2 | 0.633 |
MATK |
0.688 | -0.119 | -1 | 0.692 |
MUSK |
0.686 | -0.149 | 1 | 0.274 |
ERBB4 |
0.684 | -0.063 | 1 | 0.282 |
YANK2 |
0.684 | -0.102 | 2 | 0.362 |
EPHA2 |
0.683 | -0.093 | -1 | 0.721 |
IGF1R |
0.682 | -0.116 | 3 | 0.703 |
SYK |
0.681 | -0.078 | -1 | 0.736 |
CK1G3 |
0.674 | -0.105 | -3 | 0.279 |
ZAP70 |
0.666 | -0.078 | -1 | 0.667 |
FES |
0.665 | -0.145 | -1 | 0.670 |
CK1G2 |
0.652 | -0.109 | -3 | 0.378 |