Motif 639 (n=168)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0G2JS52 None S43 ochoa Myelin transcription factor 1 domain-containing protein None
A6NDB9 PALM3 S544 ochoa Paralemmin-3 ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}.
E9PCH4 None S1256 ochoa Rap guanine nucleotide exchange factor 6 None
O00193 SMAP S87 ochoa Small acidic protein None
O00233 PSMD9 Y41 ochoa 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. {ECO:0000269|PubMed:19490896}.
O15013 ARHGEF10 S198 ochoa Rho guanine nucleotide exchange factor 10 May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.
O43491 EPB41L2 S884 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O43493 TGOLN2 S306 ochoa Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) May be involved in regulating membrane traffic to and from trans-Golgi network.
O43572 AKAP10 S202 ochoa A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}.
O43583 DENR S73 ochoa|psp Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:37875108}.
O60216 RAD21 S138 ochoa Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
O60271 SPAG9 S109 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60271 SPAG9 S314 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60664 PLIN3 S130 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O60669 SLC16A7 S454 ochoa Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}.
O60934 NBN S615 ochoa|psp Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}.
O75363 BCAS1 S234 ochoa Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}.
O94916 NFAT5 S158 psp Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
O95359 TACC2 S2250 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
P01833 PIGR S708 ochoa Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}.
P05060 CHGB S146 ochoa Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
P05067 APP S198 psp Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
P06732 CKM S164 ochoa Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.
P07237 P4HB S427 ochoa|psp Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}.
P09874 PARP1 S177 ochoa|psp Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.
P10645 CHGA S112 ochoa|psp Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.
P12270 TPR S1462 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P20042 EIF2S2 S39 ochoa Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}.
P20700 LMNB1 S534 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P25440 BRD2 S679 ochoa Bromodomain-containing protein 2 (O27.1.1) Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}.
P25705 ATP5F1A S65 ochoa ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}.
P29374 ARID4A S716 ochoa AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
P41236 PPP1R2 Y114 ochoa Protein phosphatase inhibitor 2 (IPP-2) Inhibitor of protein-phosphatase 1.
P41970 ELK3 S173 ochoa ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
P46100 ATRX S925 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P49321 NASP S408 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P51531 SMARCA2 S591 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51608 MECP2 S53 ochoa Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P54296 MYOM2 S151 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54296 MYOM2 S1392 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55196 AFDN S1262 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P55884 EIF3B S307 ochoa Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P61129 ZC3H6 S188 ochoa Zinc finger CCCH domain-containing protein 6 None
P98182 ZNF200 S182 ochoa Zinc finger protein 200 Localizes protein arginine N-methyltransferase PRMT3 to the nucleus. {ECO:0000269|PubMed:39513743}.
Q01538 MYT1 S335 ochoa Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}.
Q01970 PLCB3 S537 ochoa|psp 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}.
Q05682 CALD1 S73 ochoa Caldesmon (CDM) Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.
Q05682 CALD1 S129 ochoa Caldesmon (CDM) Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.
Q12955 ANK3 S4290 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q13177 PAK2 S42 ochoa Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.
Q14151 SAFB2 S82 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14151 SAFB2 S194 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14289 PTK2B S389 ochoa Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}.
Q14839 CHD4 S1570 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q14839 CHD4 S1576 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q14980 NUMA1 S1149 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15311 RALBP1 S461 ochoa RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.
Q15651 HMGN3 S78 ochoa High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
Q15678 PTPN14 S937 ochoa Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Q15746 MYLK S1438 ochoa Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q15910 EZH2 S412 ochoa Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}.
Q16891 IMMT S356 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q32MZ4 LRRFIP1 S467 ochoa Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Q32MZ4 LRRFIP1 S739 ochoa Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Q3B820 FAM161A S466 ochoa Protein FAM161A Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}.
Q3L8U1 CHD9 S1472 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q5T0F9 CC2D1B S613 ochoa Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}.
Q5T200 ZC3H13 S1056 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5TAP6 UTP14C S301 ochoa U3 small nucleolar RNA-associated protein 14 homolog C Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}.
Q5VSL9 STRIP1 S65 ochoa Striatin-interacting protein 1 (Protein FAM40A) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}.
Q5VUB5 FAM171A1 S381 ochoa Protein FAM171A1 (Astroprincin) (APCN) Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.
Q68CQ4 UTP25 S150 ochoa U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}.
Q68DK2 ZFYVE26 S1893 ochoa Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.
Q69YH5 CDCA2 S437 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6IQ55 TTBK2 S577 ochoa Tau-tubulin kinase 2 (EC 2.7.11.1) Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}.
Q6NXS1 PPP1R2B Y114 ochoa Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.
Q6P3S1 DENND1B S711 ochoa DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}.
Q6PKG0 LARP1 S584 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6PL18 ATAD2 S969 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6UXY8 TMC5 S967 ochoa Transmembrane channel-like protein 5 Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}.
Q6ZMS4 ZNF852 S144 ochoa Zinc finger protein 852 May be involved in transcriptional regulation. {ECO:0000250}.
Q70EL4 USP43 S818 ochoa Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.
Q7L3B6 CDC37L1 S88 ochoa Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}.
Q7RTS9 DYM S510 ochoa Dymeclin (Dyggve-Melchior-Clausen syndrome protein) Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.
Q7Z591 AKNA S38 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q7Z6J4 FGD2 S22 ochoa FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}.
Q86WA8 LONP2 S592 ochoa Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon) ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}.
Q86WN1 FCHSD1 S435 ochoa F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}.
Q8IX03 WWC1 S651 ochoa Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}.
Q8IZT6 ASPM S211 ochoa Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.
Q8N163 CCAR2 S678 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N201 INTS1 S307 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8N3D4 EHBP1L1 S734 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N3K9 CMYA5 S1708 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N680 ZBTB2 S488 ochoa Zinc finger and BTB domain-containing protein 2 May be involved in transcriptional regulation.
Q8NC51 SERBP1 S252 ochoa SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}.
Q8NEC7 GSTCD S234 ochoa Glutathione S-transferase C-terminal domain-containing protein None
Q8NFG4 FLCN S302 ochoa Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}.
Q8TDY2 RB1CC1 S986 ochoa RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.
Q8TEQ6 GEMIN5 S765 ochoa Gem-associated protein 5 (Gemin5) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.
Q8TEU7 RAPGEF6 S1206 ochoa Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Q8WU20 FRS2 S226 ochoa Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Q8WU90 ZC3H15 S360 ochoa Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}.
Q8WUB8 PHF10 S67 ochoa PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
Q8WYB5 KAT6B S1303 ochoa Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.
Q92610 ZNF592 S298 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92794 KAT6A S826 ochoa Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.
Q969F1 GTF3C6 S160 ochoa General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}.
Q969G3 SMARCE1 S353 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q96A49 SYAP1 S313 ochoa Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.
Q96PU5 NEDD4L S184 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96Q89 KIF20B S1592 ochoa Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.
Q96RL1 UIMC1 S171 ochoa BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.
Q96RT1 ERBIN S620 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96RU3 FNBP1 S527 ochoa Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
Q96TC7 RMDN3 S212 ochoa Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.
Q99081 TCF12 S508 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99590 SCAF11 S393 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q9BRQ6 CHCHD6 S126 ochoa MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}.
Q9BS91 SLC35A5 S402 ochoa UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}.
Q9BUR4 WRAP53 S103 ochoa Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}.
Q9BVJ6 UTP14A S302 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9BX63 BRIP1 S1106 ochoa Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}.
Q9BXT4 TDRD1 S685 ochoa Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}.
Q9C0C2 TNKS1BP1 S1248 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C9 UBE2O S429 ochoa (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}.
Q9H0E3 SAP130 S855 ochoa Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.
Q9H1E3 NUCKS1 S58 ochoa Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}.
Q9H223 EHD4 S482 ochoa EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}.
Q9H501 ESF1 S190 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9HBG7 LY9 S628 ochoa T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.
Q9NP72 RAB18 S144 ochoa Ras-related protein Rab-18 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985). {ECO:0000250|UniProtKB:P35293, ECO:0000269|PubMed:21473985, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:30970241}.
Q9NQX4 MYO5C S1113 ochoa Unconventional myosin-Vc May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.
Q9NSK0 KLC4 S163 ochoa Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.
Q9NUA8 ZBTB40 S703 ochoa Zinc finger and BTB domain-containing protein 40 May be involved in transcriptional regulation.
Q9NUQ6 SPATS2L S338 ochoa SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) None
Q9NVR5 DNAAF2 S787 ochoa Protein kintoun (Dynein assembly factor 2, axonemal) Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}.
Q9NWS9 ZNF446 S141 ochoa Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) May be involved in transcriptional regulation.
Q9NYF8 BCLAF1 S181 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NZ63 C9orf78 S101 ochoa Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.
Q9P2R6 RERE S40 ochoa Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.
Q9UD71 PPP1R1B S94 ochoa Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) Inhibitor of protein-phosphatase 1.
Q9UEY8 ADD3 S618 ochoa Gamma-adducin (Adducin-like protein 70) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}.
Q9UKA4 AKAP11 S1487 ochoa A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UKK3 PARP4 S1511 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9ULI0 ATAD2B S1314 ochoa ATPase family AAA domain-containing protein 2B None
Q9UNH7 SNX6 S194 ochoa Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}.
Q9UPV0 CEP164 S487 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UPZ3 HPS5 S695 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9Y2H5 PLEKHA6 S961 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y2M0 FAN1 S209 ochoa Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}.
Q9Y365 STARD10 S246 ochoa START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}.
Q9Y487 ATP6V0A2 S704 ochoa V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}.
Q9Y520 PRRC2C S633 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y520 PRRC2C S1100 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
P08238 HSP90AB1 S474 Sugiyama Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
Q12802 AKAP13 S906 Sugiyama A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q92888 ARHGEF1 S409 Sugiyama Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Q92785 DPF2 S251 EPSD Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.
Q1KMD3 HNRNPUL2 Y215 Sugiyama Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) None
P16949 STMN1 S94 Sugiyama Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
O00625 PIR S225 Sugiyama Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase) Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:15951572, ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}.
Q13224 GRIN2B S383 iPTMNet Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}.
O43290 SART1 S117 Sugiyama U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}.
P11586 MTHFD1 S771 Sugiyama C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}.
P12270 TPR S1241 Sugiyama Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
Q8TDX7 NEK7 S260 Sugiyama Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:31409757, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.
Q9Y5S2 CDC42BPB S437 Sugiyama Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Download
reactome_id name p -log10_p
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 0.000237 3.626
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.000185 3.732
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.000469 3.329
R-HSA-9932451 SWI/SNF chromatin remodelers 0.000416 3.380
R-HSA-9932444 ATP-dependent chromatin remodelers 0.000416 3.380
R-HSA-4839726 Chromatin organization 0.000218 3.661
R-HSA-8986944 Transcriptional Regulation by MECP2 0.000911 3.040
R-HSA-9022692 Regulation of MECP2 expression and activity 0.000975 3.011
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.001097 2.960
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.001097 2.960
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.001280 2.893
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.001448 2.839
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 0.002071 2.684
R-HSA-3247509 Chromatin modifying enzymes 0.002162 2.665
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.002798 2.553
R-HSA-9020591 Interleukin-12 signaling 0.002518 2.599
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.003629 2.440
R-HSA-8863678 Neurodegenerative Diseases 0.004616 2.336
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.004616 2.336
R-HSA-447115 Interleukin-12 family signaling 0.004421 2.354
R-HSA-9022707 MECP2 regulates transcription factors 0.005589 2.253
R-HSA-8949613 Cristae formation 0.005998 2.222
R-HSA-193648 NRAGE signals death through JNK 0.005722 2.242
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.005998 2.222
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.007051 2.152
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.009244 2.034
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.008980 2.047
R-HSA-9005895 Pervasive developmental disorders 0.013705 1.863
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.013705 1.863
R-HSA-9697154 Disorders of Nervous System Development 0.013705 1.863
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.012730 1.895
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.015362 1.814
R-HSA-416482 G alpha (12/13) signalling events 0.015515 1.809
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.021745 1.663
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.021745 1.663
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.021745 1.663
R-HSA-9673013 Diseases of Telomere Maintenance 0.021745 1.663
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.021745 1.663
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.021745 1.663
R-HSA-5602566 TICAM1 deficiency - HSE 0.021745 1.663
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.018917 1.723
R-HSA-9675151 Disorders of Developmental Biology 0.022783 1.642
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.021206 1.674
R-HSA-9645723 Diseases of programmed cell death 0.022913 1.640
R-HSA-5602571 TRAF3 deficiency - HSE 0.032440 1.489
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.043020 1.366
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.043020 1.366
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.043020 1.366
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.043020 1.366
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.043020 1.366
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.043020 1.366
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.043020 1.366
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.043020 1.366
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.043020 1.366
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.043020 1.366
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.043020 1.366
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.043020 1.366
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.029130 1.536
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.031385 1.503
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.031385 1.503
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.031385 1.503
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.031385 1.503
R-HSA-8957275 Post-translational protein phosphorylation 0.033075 1.480
R-HSA-9613829 Chaperone Mediated Autophagy 0.026943 1.570
R-HSA-2980766 Nuclear Envelope Breakdown 0.035600 1.449
R-HSA-844456 The NLRP3 inflammasome 0.029130 1.536
R-HSA-445355 Smooth Muscle Contraction 0.030361 1.518
R-HSA-352238 Breakdown of the nuclear lamina 0.032440 1.489
R-HSA-983189 Kinesins 0.039815 1.400
R-HSA-3214847 HATs acetylate histones 0.034024 1.468
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.035034 1.456
R-HSA-9842860 Regulation of endogenous retroelements 0.036963 1.432
R-HSA-1640170 Cell Cycle 0.031186 1.506
R-HSA-193704 p75 NTR receptor-mediated signalling 0.034024 1.468
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.043267 1.364
R-HSA-9700206 Signaling by ALK in cancer 0.043267 1.364
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.063834 1.195
R-HSA-2562578 TRIF-mediated programmed cell death 0.104122 0.982
R-HSA-72731 Recycling of eIF2:GDP 0.104122 0.982
R-HSA-2470946 Cohesin Loading onto Chromatin 0.104122 0.982
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.113922 0.943
R-HSA-9613354 Lipophagy 0.123615 0.908
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.133203 0.875
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.133203 0.875
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.152066 0.818
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.046254 1.335
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.057325 1.242
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.188577 0.725
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.188577 0.725
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.078601 1.105
R-HSA-418217 G beta:gamma signalling through PLC beta 0.223525 0.651
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.232025 0.634
R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.240433 0.619
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.119559 0.922
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.256975 0.590
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.256975 0.590
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.256975 0.590
R-HSA-1221632 Meiotic synapsis 0.145402 0.837
R-HSA-72649 Translation initiation complex formation 0.149184 0.826
R-HSA-72702 Ribosomal scanning and start codon recognition 0.156806 0.805
R-HSA-445095 Interaction between L1 and Ankyrins 0.304483 0.516
R-HSA-194441 Metabolism of non-coding RNA 0.168373 0.774
R-HSA-191859 snRNP Assembly 0.168373 0.774
R-HSA-9615710 Late endosomal microautophagy 0.319638 0.495
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.327091 0.485
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.334464 0.476
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.334464 0.476
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.334464 0.476
R-HSA-1855170 IPs transport between nucleus and cytosol 0.348969 0.457
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.348969 0.457
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.288650 0.540
R-HSA-5693607 Processing of DNA double-strand break ends 0.075837 1.120
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.152066 0.818
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.206242 0.686
R-HSA-5654710 PI-3K cascade:FGFR3 0.232025 0.634
R-HSA-5654720 PI-3K cascade:FGFR4 0.240433 0.619
R-HSA-5654689 PI-3K cascade:FGFR1 0.265112 0.577
R-HSA-5654695 PI-3K cascade:FGFR2 0.288993 0.539
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.265112 0.577
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.152066 0.818
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.256975 0.590
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.265112 0.577
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.288993 0.539
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.312102 0.506
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.296740 0.528
R-HSA-8951936 RUNX3 regulates p14-ARF 0.161345 0.792
R-HSA-5693606 DNA Double Strand Break Response 0.199848 0.699
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.168373 0.774
R-HSA-5693538 Homology Directed Repair 0.058872 1.230
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 0.161345 0.792
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.348969 0.457
R-HSA-171319 Telomere Extension By Telomerase 0.312102 0.506
R-HSA-5693532 DNA Double-Strand Break Repair 0.120814 0.918
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.162297 0.790
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.069209 1.160
R-HSA-5693537 Resolution of D-Loop Structures 0.072296 1.141
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.327091 0.485
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.074072 1.130
R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.084199 1.075
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.069209 1.160
R-HSA-180024 DARPP-32 events 0.319638 0.495
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.145402 0.837
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.344395 0.463
R-HSA-5654708 Downstream signaling of activated FGFR3 0.319638 0.495
R-HSA-5654716 Downstream signaling of activated FGFR4 0.327091 0.485
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.075428 1.122
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.199848 0.699
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.094215 1.026
R-HSA-69478 G2/M DNA replication checkpoint 0.094215 1.026
R-HSA-192814 vRNA Synthesis 0.142686 0.846
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.152066 0.818
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.152066 0.818
R-HSA-525793 Myogenesis 0.048940 1.310
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.161345 0.792
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.161345 0.792
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.170522 0.768
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.170522 0.768
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.072296 1.141
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.075428 1.122
R-HSA-500657 Presynaptic function of Kainate receptors 0.223525 0.651
R-HSA-1500620 Meiosis 0.083902 1.076
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.180081 0.745
R-HSA-162588 Budding and maturation of HIV virion 0.334464 0.476
R-HSA-68877 Mitotic Prometaphase 0.205914 0.686
R-HSA-5655291 Signaling by FGFR4 in disease 0.179599 0.746
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.288993 0.539
R-HSA-5655302 Signaling by FGFR1 in disease 0.101904 0.992
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.280549 0.552
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.223525 0.651
R-HSA-9620244 Long-term potentiation 0.288993 0.539
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.327091 0.485
R-HSA-8963888 Chylomicron assembly 0.142686 0.846
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.088366 1.054
R-HSA-3214815 HDACs deacetylate histones 0.152985 0.815
R-HSA-9675126 Diseases of mitotic cell cycle 0.341756 0.466
R-HSA-170968 Frs2-mediated activation 0.170522 0.768
R-HSA-8849932 Synaptic adhesion-like molecules 0.223525 0.651
R-HSA-1226099 Signaling by FGFR in disease 0.227909 0.642
R-HSA-9837999 Mitochondrial protein degradation 0.316900 0.499
R-HSA-8964041 LDL remodeling 0.104122 0.982
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.113922 0.943
R-HSA-9706019 RHOBTB3 ATPase cycle 0.142686 0.846
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.197458 0.705
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.223525 0.651
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.223525 0.651
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.164501 0.784
R-HSA-5655332 Signaling by FGFR3 in disease 0.304483 0.516
R-HSA-77387 Insulin receptor recycling 0.312102 0.506
R-HSA-157579 Telomere Maintenance 0.332935 0.478
R-HSA-68886 M Phase 0.157539 0.803
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.059050 1.229
R-HSA-6794361 Neurexins and neuroligins 0.141640 0.849
R-HSA-3371556 Cellular response to heat stress 0.186574 0.729
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.126820 0.897
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.281119 0.551
R-HSA-73894 DNA Repair 0.241471 0.617
R-HSA-9612973 Autophagy 0.299541 0.524
R-HSA-9032500 Activated NTRK2 signals through FYN 0.113922 0.943
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.069209 1.160
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.078601 1.105
R-HSA-399997 Acetylcholine regulates insulin secretion 0.206242 0.686
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.240433 0.619
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.348969 0.457
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.352826 0.452
R-HSA-8856688 Golgi-to-ER retrograde transport 0.081651 1.088
R-HSA-3928664 Ephrin signaling 0.223525 0.651
R-HSA-6794362 Protein-protein interactions at synapses 0.272442 0.565
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.223525 0.651
R-HSA-169893 Prolonged ERK activation events 0.197458 0.705
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.296780 0.528
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 0.133203 0.875
R-HSA-428540 Activation of RAC1 0.152066 0.818
R-HSA-433692 Proton-coupled monocarboxylate transport 0.152066 0.818
R-HSA-622312 Inflammasomes 0.054477 1.264
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.188577 0.725
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.256975 0.590
R-HSA-69473 G2/M DNA damage checkpoint 0.062612 1.203
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.273159 0.564
R-HSA-400451 Free fatty acids regulate insulin secretion 0.273159 0.564
R-HSA-429947 Deadenylation of mRNA 0.281119 0.551
R-HSA-933542 TRAF6 mediated NF-kB activation 0.281119 0.551
R-HSA-9839394 TGFBR3 expression 0.288993 0.539
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.252170 0.598
R-HSA-1839124 FGFR1 mutant receptor activation 0.348969 0.457
R-HSA-68875 Mitotic Prophase 0.061506 1.211
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.319638 0.495
R-HSA-5656169 Termination of translesion DNA synthesis 0.319638 0.495
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.119559 0.922
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.119559 0.922
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.312102 0.506
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.319638 0.495
R-HSA-164944 Nef and signal transduction 0.094215 1.026
R-HSA-8866423 VLDL assembly 0.094215 1.026
R-HSA-5336415 Uptake and function of diphtheria toxin 0.104122 0.982
R-HSA-9834752 Respiratory syncytial virus genome replication 0.123615 0.908
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.179599 0.746
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.069209 1.160
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.123176 0.909
R-HSA-8943724 Regulation of PTEN gene transcription 0.172261 0.764
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.348969 0.457
R-HSA-199991 Membrane Trafficking 0.120891 0.918
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.276496 0.558
R-HSA-1852241 Organelle biogenesis and maintenance 0.082944 1.081
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.051682 1.287
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.114787 0.940
R-HSA-1474165 Reproduction 0.217412 0.663
R-HSA-9840373 Cellular response to mitochondrial stress 0.123615 0.908
R-HSA-389359 CD28 dependent Vav1 pathway 0.170522 0.768
R-HSA-71288 Creatine metabolism 0.240433 0.619
R-HSA-5689901 Metalloprotease DUBs 0.296780 0.528
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.312102 0.506
R-HSA-69481 G2/M Checkpoints 0.072658 1.139
R-HSA-5653656 Vesicle-mediated transport 0.304509 0.516
R-HSA-9031628 NGF-stimulated transcription 0.126820 0.897
R-HSA-8963898 Plasma lipoprotein assembly 0.281119 0.551
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.187953 0.726
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.066166 1.179
R-HSA-9675135 Diseases of DNA repair 0.119559 0.922
R-HSA-2559583 Cellular Senescence 0.177172 0.752
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.256975 0.590
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.265112 0.577
R-HSA-8863795 Downregulation of ERBB2 signaling 0.327091 0.485
R-HSA-2682334 EPH-Ephrin signaling 0.308850 0.510
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.162213 0.790
R-HSA-69278 Cell Cycle, Mitotic 0.199358 0.700
R-HSA-3214858 RMTs methylate histone arginines 0.112407 0.949
R-HSA-397795 G-protein beta:gamma signalling 0.348969 0.457
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.044271 1.354
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.219856 0.658
R-HSA-373755 Semaphorin interactions 0.184011 0.735
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.172261 0.764
R-HSA-264876 Insulin processing 0.304483 0.516
R-HSA-74160 Gene expression (Transcription) 0.102097 0.991
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.166510 0.779
R-HSA-9609507 Protein localization 0.290596 0.537
R-HSA-9683610 Maturation of nucleoprotein 0.170522 0.768
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.197458 0.705
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.327091 0.485
R-HSA-166520 Signaling by NTRKs 0.111700 0.952
R-HSA-212436 Generic Transcription Pathway 0.204735 0.689
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.208892 0.680
R-HSA-73857 RNA Polymerase II Transcription 0.184934 0.733
R-HSA-9020558 Interleukin-2 signaling 0.142686 0.846
R-HSA-212165 Epigenetic regulation of gene expression 0.178106 0.749
R-HSA-391160 Signal regulatory protein family interactions 0.179599 0.746
R-HSA-9629569 Protein hydroxylation 0.240433 0.619
R-HSA-2559580 Oxidative Stress Induced Senescence 0.352826 0.452
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.060223 1.220
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.223525 0.651
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.281119 0.551
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.211829 0.674
R-HSA-74752 Signaling by Insulin receptor 0.308850 0.510
R-HSA-75153 Apoptotic execution phase 0.119559 0.922
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.258017 0.588
R-HSA-9020933 Interleukin-23 signaling 0.113922 0.943
R-HSA-1592230 Mitochondrial biogenesis 0.057577 1.240
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.348969 0.457
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.211829 0.674
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.332935 0.478
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.156806 0.805
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.353356 0.452
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.353356 0.452
R-HSA-9705683 SARS-CoV-2-host interactions 0.291160 0.536
R-HSA-9008059 Interleukin-37 signaling 0.060223 1.220
R-HSA-9694631 Maturation of nucleoprotein 0.232025 0.634
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.265112 0.577
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.052556 1.279
R-HSA-109581 Apoptosis 0.317472 0.498
R-HSA-9006936 Signaling by TGFB family members 0.311491 0.507
R-HSA-156711 Polo-like kinase mediated events 0.223525 0.651
R-HSA-418990 Adherens junctions interactions 0.266861 0.574
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.126820 0.897
R-HSA-421270 Cell-cell junction organization 0.347964 0.458
R-HSA-1251985 Nuclear signaling by ERBB4 0.095065 1.022
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.296780 0.528
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.348969 0.457
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.320918 0.494
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.206242 0.686
R-HSA-9679191 Potential therapeutics for SARS 0.281671 0.550
R-HSA-9012852 Signaling by NOTCH3 0.152985 0.815
R-HSA-1500931 Cell-Cell communication 0.310838 0.507
R-HSA-390466 Chaperonin-mediated protein folding 0.284600 0.546
R-HSA-5633007 Regulation of TP53 Activity 0.134091 0.873
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.273159 0.564
R-HSA-9694635 Translation of Structural Proteins 0.240024 0.620
R-HSA-1236394 Signaling by ERBB4 0.227909 0.642
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.280549 0.552
R-HSA-391251 Protein folding 0.308850 0.510
R-HSA-9856651 MITF-M-dependent gene expression 0.281671 0.550
R-HSA-2028269 Signaling by Hippo 0.214931 0.668
R-HSA-9694516 SARS-CoV-2 Infection 0.221924 0.654
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.308850 0.510
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.341756 0.466
R-HSA-9679506 SARS-CoV Infections 0.300956 0.521
R-HSA-446652 Interleukin-1 family signaling 0.287618 0.541
R-HSA-449147 Signaling by Interleukins 0.101414 0.994
R-HSA-73887 Death Receptor Signaling 0.122674 0.911
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.356103 0.448
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.356103 0.448
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.356103 0.448
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.356103 0.448
R-HSA-5223345 Miscellaneous transport and binding events 0.356103 0.448
R-HSA-111885 Opioid Signalling 0.360726 0.443
R-HSA-5696400 Dual Incision in GG-NER 0.363160 0.440
R-HSA-180746 Nuclear import of Rev protein 0.363160 0.440
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.363160 0.440
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.363160 0.440
R-HSA-69620 Cell Cycle Checkpoints 0.365350 0.437
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.368591 0.433
R-HSA-169911 Regulation of Apoptosis 0.370139 0.432
R-HSA-5654696 Downstream signaling of activated FGFR2 0.370139 0.432
R-HSA-5654687 Downstream signaling of activated FGFR1 0.370139 0.432
R-HSA-381042 PERK regulates gene expression 0.370139 0.432
R-HSA-917977 Transferrin endocytosis and recycling 0.370139 0.432
R-HSA-187687 Signalling to ERKs 0.370139 0.432
R-HSA-211000 Gene Silencing by RNA 0.376418 0.424
R-HSA-212300 PRC2 methylates histones and DNA 0.377043 0.424
R-HSA-74158 RNA Polymerase III Transcription 0.377043 0.424
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.377043 0.424
R-HSA-3371511 HSF1 activation 0.377043 0.424
R-HSA-432720 Lysosome Vesicle Biogenesis 0.377043 0.424
R-HSA-163560 Triglyceride catabolism 0.377043 0.424
R-HSA-8853659 RET signaling 0.377043 0.424
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.380317 0.420
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.380317 0.420
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.380317 0.420
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.383871 0.416
R-HSA-196757 Metabolism of folate and pterines 0.383871 0.416
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.384205 0.415
R-HSA-166166 MyD88-independent TLR4 cascade 0.388084 0.411
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.388084 0.411
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.390625 0.408
R-HSA-69275 G2/M Transition 0.391974 0.407
R-HSA-1483249 Inositol phosphate metabolism 0.395808 0.403
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.397305 0.401
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.397305 0.401
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.397305 0.401
R-HSA-201556 Signaling by ALK 0.397305 0.401
R-HSA-9648002 RAS processing 0.397305 0.401
R-HSA-8953750 Transcriptional Regulation by E2F6 0.397305 0.401
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.397305 0.401
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.397870 0.400
R-HSA-453274 Mitotic G2-G2/M phases 0.397870 0.400
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.399653 0.398
R-HSA-5617833 Cilium Assembly 0.403751 0.394
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.403912 0.394
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.403912 0.394
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.403912 0.394
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.403912 0.394
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.403912 0.394
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.403912 0.394
R-HSA-177243 Interactions of Rev with host cellular proteins 0.403912 0.394
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.403912 0.394
R-HSA-3371568 Attenuation phase 0.403912 0.394
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.403912 0.394
R-HSA-5260271 Diseases of Immune System 0.403912 0.394
R-HSA-202433 Generation of second messenger molecules 0.403912 0.394
R-HSA-451927 Interleukin-2 family signaling 0.403912 0.394
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.410447 0.387
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.410447 0.387
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.410447 0.387
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.410447 0.387
R-HSA-9694548 Maturation of spike protein 0.410447 0.387
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.410447 0.387
R-HSA-3214841 PKMTs methylate histone lysines 0.410447 0.387
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.411121 0.386
R-HSA-446728 Cell junction organization 0.414819 0.382
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.414920 0.382
R-HSA-72163 mRNA Splicing - Major Pathway 0.415465 0.381
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.416912 0.380
R-HSA-9683701 Translation of Structural Proteins 0.416912 0.380
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.417275 0.380
R-HSA-72737 Cap-dependent Translation Initiation 0.418707 0.378
R-HSA-72613 Eukaryotic Translation Initiation 0.418707 0.378
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.421294 0.375
R-HSA-9007101 Rab regulation of trafficking 0.422481 0.374
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.423305 0.373
R-HSA-1280215 Cytokine Signaling in Immune system 0.428247 0.368
R-HSA-5654743 Signaling by FGFR4 0.429629 0.367
R-HSA-9710421 Defective pyroptosis 0.429629 0.367
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.429629 0.367
R-HSA-3928662 EPHB-mediated forward signaling 0.435884 0.361
R-HSA-9907900 Proteasome assembly 0.435884 0.361
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.435884 0.361
R-HSA-73886 Chromosome Maintenance 0.437452 0.359
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.442071 0.355
R-HSA-5654741 Signaling by FGFR3 0.442071 0.355
R-HSA-6783310 Fanconi Anemia Pathway 0.442071 0.355
R-HSA-2132295 MHC class II antigen presentation 0.444858 0.352
R-HSA-72172 mRNA Splicing 0.447277 0.349
R-HSA-72165 mRNA Splicing - Minor Pathway 0.448190 0.349
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.448190 0.349
R-HSA-9839373 Signaling by TGFBR3 0.448190 0.349
R-HSA-162909 Host Interactions of HIV factors 0.448542 0.348
R-HSA-5357801 Programmed Cell Death 0.450137 0.347
R-HSA-1483191 Synthesis of PC 0.454242 0.343
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.454242 0.343
R-HSA-194138 Signaling by VEGF 0.455867 0.341
R-HSA-5620924 Intraflagellar transport 0.460229 0.337
R-HSA-389356 Co-stimulation by CD28 0.460229 0.337
R-HSA-8963899 Plasma lipoprotein remodeling 0.460229 0.337
R-HSA-114608 Platelet degranulation 0.463137 0.334
R-HSA-73893 DNA Damage Bypass 0.466150 0.331
R-HSA-397014 Muscle contraction 0.469981 0.328
R-HSA-5655253 Signaling by FGFR2 in disease 0.472007 0.326
R-HSA-109704 PI3K Cascade 0.472007 0.326
R-HSA-9730414 MITF-M-regulated melanocyte development 0.472790 0.325
R-HSA-3371571 HSF1-dependent transactivation 0.477799 0.321
R-HSA-912446 Meiotic recombination 0.477799 0.321
R-HSA-5358346 Hedgehog ligand biogenesis 0.477799 0.321
R-HSA-9843745 Adipogenesis 0.481060 0.318
R-HSA-68882 Mitotic Anaphase 0.481178 0.318
R-HSA-5339562 Uptake and actions of bacterial toxins 0.483529 0.316
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.483960 0.315
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.488127 0.311
R-HSA-9639288 Amino acids regulate mTORC1 0.489196 0.311
R-HSA-162582 Signal Transduction 0.493098 0.307
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.494801 0.306
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.500345 0.301
R-HSA-9018519 Estrogen-dependent gene expression 0.502079 0.299
R-HSA-5654736 Signaling by FGFR1 0.505829 0.296
R-HSA-8935690 Digestion 0.505829 0.296
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.505829 0.296
R-HSA-8878171 Transcriptional regulation by RUNX1 0.508673 0.294
R-HSA-112399 IRS-mediated signalling 0.511252 0.291
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.511252 0.291
R-HSA-162906 HIV Infection 0.511382 0.291
R-HSA-6807070 PTEN Regulation 0.512383 0.290
R-HSA-1632852 Macroautophagy 0.519175 0.285
R-HSA-180786 Extension of Telomeres 0.521923 0.282
R-HSA-9033241 Peroxisomal protein import 0.521923 0.282
R-HSA-429914 Deadenylation-dependent mRNA decay 0.521923 0.282
R-HSA-8979227 Triglyceride metabolism 0.521923 0.282
R-HSA-72312 rRNA processing 0.524805 0.280
R-HSA-162599 Late Phase of HIV Life Cycle 0.525904 0.279
R-HSA-8873719 RAB geranylgeranylation 0.527171 0.278
R-HSA-1227986 Signaling by ERBB2 0.527171 0.278
R-HSA-8856828 Clathrin-mediated endocytosis 0.529244 0.276
R-HSA-168325 Viral Messenger RNA Synthesis 0.532361 0.274
R-HSA-112043 PLC beta mediated events 0.532361 0.274
R-HSA-2428928 IRS-related events triggered by IGF1R 0.532361 0.274
R-HSA-6784531 tRNA processing in the nucleus 0.537496 0.270
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.537496 0.270
R-HSA-1268020 Mitochondrial protein import 0.537496 0.270
R-HSA-9707616 Heme signaling 0.537496 0.270
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.537496 0.270
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.539221 0.268
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.542574 0.266
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.542574 0.266
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.542574 0.266
R-HSA-8963743 Digestion and absorption 0.542574 0.266
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.545708 0.263
R-HSA-2428924 IGF1R signaling cascade 0.547596 0.262
R-HSA-74751 Insulin receptor signalling cascade 0.547596 0.262
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.552564 0.258
R-HSA-8854518 AURKA Activation by TPX2 0.557477 0.254
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.557477 0.254
R-HSA-112040 G-protein mediated events 0.562337 0.250
R-HSA-196807 Nicotinate metabolism 0.562337 0.250
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.564933 0.248
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.567144 0.246
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.567144 0.246
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.568080 0.246
R-HSA-162587 HIV Life Cycle 0.574325 0.241
R-HSA-5683057 MAPK family signaling cascades 0.575449 0.240
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.576600 0.239
R-HSA-9711097 Cellular response to starvation 0.577423 0.239
R-HSA-427413 NoRC negatively regulates rRNA expression 0.581251 0.236
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.581251 0.236
R-HSA-3000178 ECM proteoglycans 0.581251 0.236
R-HSA-5578749 Transcriptional regulation by small RNAs 0.585852 0.232
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.590401 0.229
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.590401 0.229
R-HSA-4086398 Ca2+ pathway 0.590401 0.229
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.590401 0.229
R-HSA-2262752 Cellular responses to stress 0.594675 0.226
R-HSA-1222556 ROS and RNS production in phagocytes 0.594902 0.226
R-HSA-380287 Centrosome maturation 0.599353 0.222
R-HSA-1169408 ISG15 antiviral mechanism 0.599353 0.222
R-HSA-917937 Iron uptake and transport 0.599353 0.222
R-HSA-8953854 Metabolism of RNA 0.601709 0.221
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.603755 0.219
R-HSA-73864 RNA Polymerase I Transcription 0.612416 0.213
R-HSA-9955298 SLC-mediated transport of organic anions 0.612416 0.213
R-HSA-9824446 Viral Infection Pathways 0.613484 0.212
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.616676 0.210
R-HSA-3700989 Transcriptional Regulation by TP53 0.620681 0.207
R-HSA-5654738 Signaling by FGFR2 0.620889 0.207
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.620889 0.207
R-HSA-9833482 PKR-mediated signaling 0.620889 0.207
R-HSA-977225 Amyloid fiber formation 0.625056 0.204
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.625056 0.204
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.629177 0.201
R-HSA-9707564 Cytoprotection by HMOX1 0.633254 0.198
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.637286 0.196
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.637286 0.196
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.637286 0.196
R-HSA-5687128 MAPK6/MAPK4 signaling 0.641274 0.193
R-HSA-168255 Influenza Infection 0.641428 0.193
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.649119 0.188
R-HSA-438064 Post NMDA receptor activation events 0.652977 0.185
R-HSA-9663891 Selective autophagy 0.656794 0.183
R-HSA-5673001 RAF/MAP kinase cascade 0.662188 0.179
R-HSA-73884 Base Excision Repair 0.664301 0.178
R-HSA-983712 Ion channel transport 0.667912 0.175
R-HSA-168898 Toll-like Receptor Cascades 0.673017 0.172
R-HSA-1257604 PIP3 activates AKT signaling 0.674857 0.171
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.675258 0.171
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.675546 0.170
R-HSA-5684996 MAPK1/MAPK3 signaling 0.676934 0.169
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.682364 0.166
R-HSA-1474290 Collagen formation 0.682364 0.166
R-HSA-9609690 HCMV Early Events 0.685502 0.164
R-HSA-72689 Formation of a pool of free 40S subunits 0.689315 0.162
R-HSA-5389840 Mitochondrial translation elongation 0.692734 0.159
R-HSA-6807878 COPI-mediated anterograde transport 0.692734 0.159
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.692734 0.159
R-HSA-8878159 Transcriptional regulation by RUNX3 0.696115 0.157
R-HSA-190236 Signaling by FGFR 0.699460 0.155
R-HSA-5368286 Mitochondrial translation initiation 0.699460 0.155
R-HSA-422356 Regulation of insulin secretion 0.699460 0.155
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.699460 0.155
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.699460 0.155
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.699460 0.155
R-HSA-70171 Glycolysis 0.706039 0.151
R-HSA-382556 ABC-family proteins mediated transport 0.706039 0.151
R-HSA-9020702 Interleukin-1 signaling 0.709275 0.149
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.712475 0.147
R-HSA-1483255 PI Metabolism 0.712475 0.147
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.715640 0.145
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.718771 0.143
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.718771 0.143
R-HSA-5619507 Activation of HOX genes during differentiation 0.721867 0.142
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.721867 0.142
R-HSA-5696398 Nucleotide Excision Repair 0.724930 0.140
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.725064 0.140
R-HSA-2672351 Stimuli-sensing channels 0.733917 0.134
R-HSA-5419276 Mitochondrial translation termination 0.736848 0.133
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.736848 0.133
R-HSA-202403 TCR signaling 0.739746 0.131
R-HSA-8953897 Cellular responses to stimuli 0.741709 0.130
R-HSA-6803157 Antimicrobial peptides 0.742613 0.129
R-HSA-2871796 FCERI mediated MAPK activation 0.745448 0.128
R-HSA-422475 Axon guidance 0.748400 0.126
R-HSA-373760 L1CAM interactions 0.761819 0.118
R-HSA-9006925 Intracellular signaling by second messengers 0.762130 0.118
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.762310 0.118
R-HSA-70326 Glucose metabolism 0.764444 0.117
R-HSA-2980736 Peptide hormone metabolism 0.764444 0.117
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.767040 0.115
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.769608 0.114
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.769608 0.114
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.774659 0.111
R-HSA-388396 GPCR downstream signalling 0.775205 0.111
R-HSA-8939211 ESR-mediated signaling 0.775578 0.110
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.777143 0.109
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.777143 0.109
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.779600 0.108
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.779600 0.108
R-HSA-157118 Signaling by NOTCH 0.781065 0.107
R-HSA-9675108 Nervous system development 0.795611 0.099
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.798310 0.098
R-HSA-9609646 HCMV Infection 0.798518 0.098
R-HSA-9909396 Circadian clock 0.804911 0.094
R-HSA-388841 Regulation of T cell activation by CD28 family 0.808391 0.092
R-HSA-3858494 Beta-catenin independent WNT signaling 0.815439 0.089
R-HSA-163685 Integration of energy metabolism 0.815439 0.089
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.817476 0.088
R-HSA-5368287 Mitochondrial translation 0.819491 0.086
R-HSA-5358351 Signaling by Hedgehog 0.819491 0.086
R-HSA-416476 G alpha (q) signalling events 0.820889 0.086
R-HSA-381119 Unfolded Protein Response (UPR) 0.821483 0.085
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.825402 0.083
R-HSA-9711123 Cellular response to chemical stress 0.826861 0.083
R-HSA-76002 Platelet activation, signaling and aggregation 0.835486 0.078
R-HSA-199977 ER to Golgi Anterograde Transport 0.838458 0.077
R-HSA-69242 S Phase 0.840243 0.076
R-HSA-9824443 Parasitic Infection Pathways 0.845059 0.073
R-HSA-9658195 Leishmania infection 0.845059 0.073
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.846385 0.072
R-HSA-418594 G alpha (i) signalling events 0.851776 0.070
R-HSA-1989781 PPARA activates gene expression 0.852195 0.069
R-HSA-372790 Signaling by GPCR 0.853581 0.069
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.855443 0.068
R-HSA-9610379 HCMV Late Events 0.855443 0.068
R-HSA-1483257 Phospholipid metabolism 0.862710 0.064
R-HSA-2467813 Separation of Sister Chromatids 0.866264 0.062
R-HSA-5619102 SLC transporter disorders 0.870651 0.060
R-HSA-72766 Translation 0.874355 0.058
R-HSA-72306 tRNA processing 0.876279 0.057
R-HSA-5621481 C-type lectin receptors (CLRs) 0.877648 0.057
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.879001 0.056
R-HSA-109582 Hemostasis 0.881115 0.055
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.881663 0.055
R-HSA-9678108 SARS-CoV-1 Infection 0.882973 0.054
R-HSA-112315 Transmission across Chemical Synapses 0.892629 0.049
R-HSA-168256 Immune System 0.893244 0.049
R-HSA-375276 Peptide ligand-binding receptors 0.896457 0.047
R-HSA-6798695 Neutrophil degranulation 0.898680 0.046
R-HSA-1474244 Extracellular matrix organization 0.900000 0.046
R-HSA-112316 Neuronal System 0.907024 0.042
R-HSA-389948 Co-inhibition by PD-1 0.911408 0.040
R-HSA-948021 Transport to the Golgi and subsequent modification 0.913360 0.039
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.914321 0.039
R-HSA-1483206 Glycerophospholipid biosynthesis 0.914321 0.039
R-HSA-376176 Signaling by ROBO receptors 0.914321 0.039
R-HSA-9006931 Signaling by Nuclear Receptors 0.925030 0.034
R-HSA-196854 Metabolism of vitamins and cofactors 0.925708 0.034
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.938124 0.028
R-HSA-913531 Interferon Signaling 0.938124 0.028
R-HSA-1643685 Disease 0.943401 0.025
R-HSA-5663205 Infectious disease 0.944667 0.025
R-HSA-5619115 Disorders of transmembrane transporters 0.948150 0.023
R-HSA-5688426 Deubiquitination 0.952586 0.021
R-HSA-392499 Metabolism of proteins 0.962626 0.017
R-HSA-211945 Phase I - Functionalization of compounds 0.963346 0.016
R-HSA-597592 Post-translational protein modification 0.963430 0.016
R-HSA-168249 Innate Immune System 0.965252 0.015
R-HSA-382551 Transport of small molecules 0.966912 0.015
R-HSA-195721 Signaling by WNT 0.970705 0.013
R-HSA-1266738 Developmental Biology 0.974759 0.011
R-HSA-8957322 Metabolism of steroids 0.978119 0.010
R-HSA-1280218 Adaptive Immune System 0.979168 0.009
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.981924 0.008
R-HSA-9824439 Bacterial Infection Pathways 0.989707 0.004
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.990161 0.004
R-HSA-425407 SLC-mediated transmembrane transport 0.990488 0.004
R-HSA-446203 Asparagine N-linked glycosylation 0.992828 0.003
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.995063 0.002
R-HSA-211859 Biological oxidations 0.997718 0.001
R-HSA-500792 GPCR ligand binding 0.998925 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 0.999228 0.000
R-HSA-556833 Metabolism of lipids 0.999967 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.840 0.204 2 0.873
CLK3CLK3 0.830 0.162 1 0.810
DSTYKDSTYK 0.820 0.097 2 0.880
KISKIS 0.819 0.107 1 0.694
MOSMOS 0.818 0.041 1 0.834
PIM3PIM3 0.817 0.039 -3 0.767
NDR2NDR2 0.817 0.043 -3 0.766
NEK6NEK6 0.816 0.041 -2 0.860
GCN2GCN2 0.816 -0.029 2 0.804
RAF1RAF1 0.816 0.016 1 0.828
IKKBIKKB 0.815 0.033 -2 0.705
CDC7CDC7 0.815 -0.027 1 0.791
ATRATR 0.813 0.068 1 0.859
PRKD1PRKD1 0.813 0.077 -3 0.727
PRPKPRPK 0.813 -0.029 -1 0.861
CAMK2GCAMK2G 0.813 0.087 2 0.829
TGFBR2TGFBR2 0.812 0.062 -2 0.862
NEK7NEK7 0.812 0.018 -3 0.808
TBK1TBK1 0.811 0.003 1 0.740
GRK1GRK1 0.811 0.117 -2 0.726
PIM1PIM1 0.811 0.074 -3 0.712
BMPR2BMPR2 0.811 0.044 -2 0.871
CAMK1BCAMK1B 0.811 0.012 -3 0.783
IKKAIKKA 0.811 0.084 -2 0.702
ATMATM 0.811 0.130 1 0.814
PRKD2PRKD2 0.810 0.059 -3 0.683
IKKEIKKE 0.810 0.011 1 0.745
MTORMTOR 0.810 -0.061 1 0.776
SRPK1SRPK1 0.809 0.046 -3 0.684
SKMLCKSKMLCK 0.808 0.061 -2 0.823
NLKNLK 0.808 -0.021 1 0.819
LATS2LATS2 0.807 0.059 -5 0.733
FAM20CFAM20C 0.807 0.093 2 0.613
PKN3PKN3 0.807 -0.003 -3 0.739
ULK2ULK2 0.807 -0.086 2 0.786
CAMK2BCAMK2B 0.806 0.123 2 0.804
BMPR1BBMPR1B 0.806 0.156 1 0.700
CDKL1CDKL1 0.806 -0.010 -3 0.733
RSK2RSK2 0.805 0.029 -3 0.697
PDHK4PDHK4 0.804 -0.159 1 0.837
NDR1NDR1 0.804 -0.021 -3 0.752
GRK6GRK6 0.804 0.070 1 0.770
CHAK2CHAK2 0.803 0.014 -1 0.865
PKCDPKCD 0.803 0.018 2 0.807
MLK1MLK1 0.803 -0.046 2 0.820
TGFBR1TGFBR1 0.803 0.179 -2 0.869
LATS1LATS1 0.803 0.115 -3 0.781
HIPK4HIPK4 0.803 0.006 1 0.821
CAMLCKCAMLCK 0.803 0.007 -2 0.826
MAPKAPK2MAPKAPK2 0.802 0.061 -3 0.656
BCKDKBCKDK 0.802 -0.024 -1 0.849
PDHK1PDHK1 0.802 -0.102 1 0.840
NIKNIK 0.802 -0.051 -3 0.798
MST4MST4 0.802 -0.020 2 0.866
ERK5ERK5 0.802 -0.013 1 0.762
NUAK2NUAK2 0.801 -0.048 -3 0.764
WNK1WNK1 0.801 -0.043 -2 0.808
CAMK2DCAMK2D 0.801 0.027 -3 0.745
SRPK2SRPK2 0.801 0.033 -3 0.611
GRK5GRK5 0.800 -0.062 -3 0.792
PKN2PKN2 0.800 -0.029 -3 0.749
P90RSKP90RSK 0.799 -0.001 -3 0.699
CAMK2ACAMK2A 0.799 0.070 2 0.822
TSSK2TSSK2 0.799 0.001 -5 0.852
RIPK3RIPK3 0.799 -0.092 3 0.758
AMPKA1AMPKA1 0.799 -0.052 -3 0.763
TSSK1TSSK1 0.799 -0.009 -3 0.776
ULK1ULK1 0.799 -0.071 -3 0.756
PLK1PLK1 0.799 0.077 -2 0.843
MARK4MARK4 0.799 -0.075 4 0.471
ALK4ALK4 0.798 0.129 -2 0.881
GRK4GRK4 0.798 0.011 -2 0.793
HUNKHUNK 0.798 -0.060 2 0.792
NEK9NEK9 0.798 -0.048 2 0.835
ALK2ALK2 0.798 0.198 -2 0.866
DAPK2DAPK2 0.798 -0.041 -3 0.785
ICKICK 0.797 -0.006 -3 0.762
MAPKAPK3MAPKAPK3 0.797 -0.007 -3 0.686
CDKL5CDKL5 0.797 -0.027 -3 0.718
AURCAURC 0.797 0.031 -2 0.666
PKACGPKACG 0.797 0.003 -2 0.739
GRK7GRK7 0.797 0.081 1 0.698
ANKRD3ANKRD3 0.796 -0.058 1 0.838
DNAPKDNAPK 0.796 0.133 1 0.804
CLK4CLK4 0.796 0.058 -3 0.691
RSK3RSK3 0.796 -0.027 -3 0.694
PLK3PLK3 0.795 0.103 2 0.759
MLK3MLK3 0.795 -0.015 2 0.758
CLK2CLK2 0.795 0.107 -3 0.681
PRKXPRKX 0.795 0.082 -3 0.616
PKACBPKACB 0.795 0.060 -2 0.692
P70S6KBP70S6KB 0.795 -0.018 -3 0.715
ACVR2AACVR2A 0.794 0.110 -2 0.849
ACVR2BACVR2B 0.794 0.116 -2 0.857
TLK2TLK2 0.794 0.060 1 0.829
DLKDLK 0.794 -0.062 1 0.784
PKRPKR 0.793 0.022 1 0.852
PRKD3PRKD3 0.793 0.006 -3 0.665
CLK1CLK1 0.793 0.054 -3 0.667
SRPK3SRPK3 0.793 0.008 -3 0.665
BMPR1ABMPR1A 0.792 0.161 1 0.684
AMPKA2AMPKA2 0.792 -0.055 -3 0.733
WNK3WNK3 0.792 -0.168 1 0.821
NUAK1NUAK1 0.792 -0.050 -3 0.711
MNK2MNK2 0.791 0.005 -2 0.775
IRE2IRE2 0.791 -0.057 2 0.767
MLK2MLK2 0.791 -0.113 2 0.826
MSK2MSK2 0.791 0.003 -3 0.673
CAMK4CAMK4 0.791 -0.041 -3 0.732
IRE1IRE1 0.791 -0.107 1 0.812
RSK4RSK4 0.791 0.030 -3 0.678
PKCBPKCB 0.790 -0.013 2 0.754
CDK8CDK8 0.790 0.006 1 0.667
MSK1MSK1 0.790 0.039 -3 0.674
CDK1CDK1 0.790 0.053 1 0.621
MLK4MLK4 0.789 -0.022 2 0.730
PAK1PAK1 0.789 0.001 -2 0.760
MASTLMASTL 0.788 -0.194 -2 0.764
CDK5CDK5 0.788 0.027 1 0.693
PKCAPKCA 0.788 -0.019 2 0.745
AURBAURB 0.787 0.013 -2 0.668
NIM1NIM1 0.787 -0.078 3 0.810
RIPK1RIPK1 0.787 -0.141 1 0.805
TLK1TLK1 0.787 0.030 -2 0.860
DYRK2DYRK2 0.786 0.010 1 0.718
QSKQSK 0.786 -0.068 4 0.450
CHK1CHK1 0.786 0.013 -3 0.747
GSK3AGSK3A 0.786 -0.009 4 0.273
JNK2JNK2 0.786 0.063 1 0.615
YSK4YSK4 0.786 -0.050 1 0.764
PKCGPKCG 0.786 -0.043 2 0.747
TTBK2TTBK2 0.785 -0.112 2 0.682
MNK1MNK1 0.785 0.001 -2 0.784
MEK1MEK1 0.785 -0.086 2 0.848
MELKMELK 0.785 -0.067 -3 0.708
PHKG1PHKG1 0.785 -0.089 -3 0.736
CDK19CDK19 0.785 0.008 1 0.631
AURAAURA 0.784 0.029 -2 0.648
SMG1SMG1 0.784 -0.002 1 0.838
MYLK4MYLK4 0.784 -0.011 -2 0.758
SIKSIK 0.784 -0.067 -3 0.681
PKG2PKG2 0.784 -0.001 -2 0.684
NEK2NEK2 0.784 -0.051 2 0.806
JNK3JNK3 0.783 0.046 1 0.649
PKCZPKCZ 0.783 -0.055 2 0.778
PAK3PAK3 0.783 -0.053 -2 0.758
PKCHPKCH 0.783 -0.049 2 0.736
AKT2AKT2 0.783 0.002 -3 0.620
CDK18CDK18 0.782 0.008 1 0.607
VRK2VRK2 0.782 -0.168 1 0.853
BRAFBRAF 0.782 0.012 -4 0.806
GSK3BGSK3B 0.782 -0.049 4 0.261
CDK7CDK7 0.782 -0.027 1 0.677
HRIHRI 0.782 -0.060 -2 0.856
PLK2PLK2 0.781 0.140 -3 0.836
PERKPERK 0.781 -0.033 -2 0.838
HIPK2HIPK2 0.781 0.033 1 0.638
CHAK1CHAK1 0.781 -0.093 2 0.757
MARK2MARK2 0.781 -0.088 4 0.408
QIKQIK 0.781 -0.143 -3 0.748
GRK2GRK2 0.780 -0.021 -2 0.701
MARK3MARK3 0.779 -0.083 4 0.421
NEK5NEK5 0.779 -0.018 1 0.828
P38AP38A 0.779 0.004 1 0.694
PIM2PIM2 0.779 -0.010 -3 0.668
CDK13CDK13 0.779 -0.003 1 0.651
PAK6PAK6 0.779 -0.009 -2 0.684
SGK3SGK3 0.778 -0.011 -3 0.676
HIPK1HIPK1 0.778 0.014 1 0.733
CK1ECK1E 0.778 -0.010 -3 0.557
CAMK1GCAMK1G 0.778 -0.036 -3 0.680
CDK3CDK3 0.778 0.065 1 0.568
PAK2PAK2 0.778 -0.047 -2 0.743
PKACAPKACA 0.778 0.037 -2 0.648
MEKK1MEKK1 0.777 -0.078 1 0.804
DCAMKL1DCAMKL1 0.777 -0.029 -3 0.701
P38BP38B 0.777 0.025 1 0.619
PINK1PINK1 0.777 -0.088 1 0.842
P38GP38G 0.777 0.029 1 0.543
ERK1ERK1 0.776 0.011 1 0.616
MEKK3MEKK3 0.776 -0.058 1 0.773
BRSK1BRSK1 0.776 -0.086 -3 0.707
ZAKZAK 0.776 -0.082 1 0.757
MEKK2MEKK2 0.775 -0.070 2 0.811
CDK2CDK2 0.775 0.004 1 0.691
CDK17CDK17 0.775 0.003 1 0.550
DYRK1ADYRK1A 0.775 -0.003 1 0.742
ERK2ERK2 0.775 -0.010 1 0.660
PLK4PLK4 0.775 -0.082 2 0.623
PASKPASK 0.775 0.012 -3 0.792
SSTKSSTK 0.774 -0.059 4 0.433
CAMK1DCAMK1D 0.773 0.009 -3 0.611
CK2A2CK2A2 0.773 0.099 1 0.643
CK1DCK1D 0.773 0.001 -3 0.506
BRSK2BRSK2 0.772 -0.135 -3 0.717
MAPKAPK5MAPKAPK5 0.772 -0.080 -3 0.634
AKT1AKT1 0.772 -0.003 -3 0.632
TAO3TAO3 0.772 -0.047 1 0.779
MEK5MEK5 0.772 -0.201 2 0.827
PRP4PRP4 0.771 -0.032 -3 0.658
SMMLCKSMMLCK 0.771 -0.034 -3 0.734
MARK1MARK1 0.771 -0.109 4 0.433
IRAK4IRAK4 0.771 -0.120 1 0.813
P38DP38D 0.771 0.039 1 0.593
PKCTPKCT 0.771 -0.062 2 0.747
DYRK4DYRK4 0.770 0.028 1 0.638
DCAMKL2DCAMKL2 0.770 -0.039 -3 0.726
MST3MST3 0.770 -0.070 2 0.835
CDK12CDK12 0.770 -0.010 1 0.624
CDK16CDK16 0.770 0.014 1 0.568
CK1G1CK1G1 0.770 -0.034 -3 0.554
CDK14CDK14 0.769 -0.010 1 0.650
WNK4WNK4 0.769 -0.126 -2 0.793
GAKGAK 0.769 0.008 1 0.813
CK1A2CK1A2 0.769 -0.009 -3 0.506
GRK3GRK3 0.769 -0.018 -2 0.665
NEK8NEK8 0.768 -0.095 2 0.812
MPSK1MPSK1 0.768 -0.039 1 0.796
HIPK3HIPK3 0.767 -0.025 1 0.725
DRAK1DRAK1 0.767 -0.115 1 0.683
DYRK3DYRK3 0.767 0.002 1 0.746
CDK9CDK9 0.767 -0.028 1 0.657
PHKG2PHKG2 0.766 -0.096 -3 0.703
SNRKSNRK 0.766 -0.187 2 0.666
DAPK3DAPK3 0.766 -0.007 -3 0.722
DYRK1BDYRK1B 0.765 -0.003 1 0.662
CAMKK1CAMKK1 0.765 -0.058 -2 0.716
MST2MST2 0.765 -0.024 1 0.792
TNIKTNIK 0.764 0.003 3 0.885
GCKGCK 0.763 -0.002 1 0.792
PKCIPKCI 0.763 -0.071 2 0.750
PKCEPKCE 0.763 -0.031 2 0.733
AKT3AKT3 0.762 0.002 -3 0.563
NEK4NEK4 0.762 -0.066 1 0.809
NEK11NEK11 0.762 -0.142 1 0.774
P70S6KP70S6K 0.762 -0.065 -3 0.628
CAMK1ACAMK1A 0.761 -0.001 -3 0.584
EEF2KEEF2K 0.761 -0.021 3 0.847
CDK10CDK10 0.761 -0.009 1 0.637
LKB1LKB1 0.761 -0.078 -3 0.748
TAK1TAK1 0.761 -0.014 1 0.818
TAO2TAO2 0.760 -0.107 2 0.854
PDHK3_TYRPDHK3_TYR 0.760 0.236 4 0.553
SGK1SGK1 0.760 0.010 -3 0.548
CHK2CHK2 0.760 -0.022 -3 0.561
MRCKAMRCKA 0.760 0.001 -3 0.671
JNK1JNK1 0.760 0.020 1 0.598
ROCK2ROCK2 0.760 0.013 -3 0.701
CK2A1CK2A1 0.760 0.055 1 0.620
TTKTTK 0.759 0.046 -2 0.856
BUB1BUB1 0.759 0.040 -5 0.811
MINKMINK 0.759 -0.048 1 0.799
MAKMAK 0.758 0.029 -2 0.676
PAK5PAK5 0.758 -0.041 -2 0.633
HGKHGK 0.758 -0.066 3 0.881
MRCKBMRCKB 0.758 -0.002 -3 0.654
IRAK1IRAK1 0.758 -0.200 -1 0.751
NEK1NEK1 0.758 -0.049 1 0.801
CAMKK2CAMKK2 0.757 -0.117 -2 0.710
PDK1PDK1 0.757 -0.102 1 0.777
DAPK1DAPK1 0.756 -0.024 -3 0.708
MST1MST1 0.756 -0.031 1 0.789
PKN1PKN1 0.756 -0.062 -3 0.638
TTBK1TTBK1 0.755 -0.141 2 0.597
PAK4PAK4 0.755 -0.033 -2 0.644
ERK7ERK7 0.754 -0.038 2 0.518
KHS1KHS1 0.754 -0.006 1 0.800
LOKLOK 0.753 -0.081 -2 0.730
MAP3K15MAP3K15 0.753 -0.138 1 0.749
CDK6CDK6 0.753 -0.013 1 0.635
PDHK4_TYRPDHK4_TYR 0.752 0.113 2 0.877
DMPK1DMPK1 0.752 0.018 -3 0.680
KHS2KHS2 0.752 -0.001 1 0.810
SLKSLK 0.752 -0.057 -2 0.672
HPK1HPK1 0.751 -0.058 1 0.785
VRK1VRK1 0.751 -0.133 2 0.842
LRRK2LRRK2 0.751 -0.152 2 0.833
MEKK6MEKK6 0.750 -0.186 1 0.781
SBKSBK 0.750 -0.000 -3 0.507
CDK4CDK4 0.750 -0.017 1 0.618
MAP2K6_TYRMAP2K6_TYR 0.749 0.068 -1 0.896
OSR1OSR1 0.749 -0.023 2 0.805
MOKMOK 0.749 -0.012 1 0.748
TESK1_TYRTESK1_TYR 0.748 -0.051 3 0.900
MAP2K4_TYRMAP2K4_TYR 0.748 -0.003 -1 0.885
STK33STK33 0.746 -0.109 2 0.593
MEK2MEK2 0.745 -0.173 2 0.819
BMPR2_TYRBMPR2_TYR 0.745 0.018 -1 0.893
YSK1YSK1 0.745 -0.121 2 0.810
PDHK1_TYRPDHK1_TYR 0.745 0.031 -1 0.908
ROCK1ROCK1 0.744 -0.007 -3 0.663
RIPK2RIPK2 0.744 -0.186 1 0.719
PBKPBK 0.744 -0.057 1 0.756
PKG1PKG1 0.742 -0.040 -2 0.611
EPHA6EPHA6 0.742 0.024 -1 0.904
MAP2K7_TYRMAP2K7_TYR 0.742 -0.137 2 0.854
RETRET 0.741 -0.033 1 0.791
LIMK2_TYRLIMK2_TYR 0.741 -0.071 -3 0.796
PKMYT1_TYRPKMYT1_TYR 0.740 -0.133 3 0.864
BIKEBIKE 0.740 0.009 1 0.705
PINK1_TYRPINK1_TYR 0.739 -0.126 1 0.801
CRIKCRIK 0.739 -0.015 -3 0.632
EPHB4EPHB4 0.739 0.027 -1 0.888
ALPHAK3ALPHAK3 0.739 -0.017 -1 0.802
NEK3NEK3 0.738 -0.169 1 0.761
HASPINHASPIN 0.738 -0.048 -1 0.688
MYO3BMYO3B 0.738 -0.074 2 0.826
TYK2TYK2 0.737 -0.050 1 0.792
MYO3AMYO3A 0.736 -0.067 1 0.811
ROS1ROS1 0.735 -0.061 3 0.800
CK1ACK1A 0.735 -0.027 -3 0.428
CSF1RCSF1R 0.735 -0.038 3 0.806
ABL2ABL2 0.735 -0.015 -1 0.828
INSRRINSRR 0.735 0.044 3 0.770
JAK2JAK2 0.735 -0.041 1 0.783
MST1RMST1R 0.734 -0.119 3 0.825
TXKTXK 0.733 0.027 1 0.737
FERFER 0.733 0.029 1 0.794
YANK3YANK3 0.733 -0.058 2 0.374
TYRO3TYRO3 0.733 -0.108 3 0.830
LIMK1_TYRLIMK1_TYR 0.732 -0.202 2 0.851
EPHA4EPHA4 0.732 0.043 2 0.755
JAK3JAK3 0.732 -0.060 1 0.754
YES1YES1 0.731 -0.025 -1 0.847
DDR1DDR1 0.731 -0.109 4 0.476
ASK1ASK1 0.731 -0.124 1 0.734
FGRFGR 0.730 -0.071 1 0.779
LCKLCK 0.730 -0.019 -1 0.832
KITKIT 0.728 -0.040 3 0.807
TAO1TAO1 0.728 -0.126 1 0.729
ABL1ABL1 0.728 -0.057 -1 0.817
EPHB1EPHB1 0.728 -0.006 1 0.762
HCKHCK 0.728 -0.045 -1 0.828
EPHB3EPHB3 0.727 0.011 -1 0.875
BLKBLK 0.727 0.007 -1 0.840
EPHB2EPHB2 0.727 0.022 -1 0.869
FGFR2FGFR2 0.727 -0.031 3 0.805
AAK1AAK1 0.727 0.039 1 0.610
FLT3FLT3 0.727 -0.065 3 0.819
KDRKDR 0.727 -0.069 3 0.770
SRMSSRMS 0.726 0.010 1 0.762
PDGFRBPDGFRB 0.725 -0.089 3 0.826
TNK2TNK2 0.724 -0.077 3 0.781
JAK1JAK1 0.723 -0.041 1 0.738
STLK3STLK3 0.723 -0.127 1 0.731
FLT1FLT1 0.722 -0.027 -1 0.889
NEK10_TYRNEK10_TYR 0.722 -0.090 1 0.687
ITKITK 0.721 -0.073 -1 0.805
TNK1TNK1 0.721 -0.106 3 0.806
METMET 0.721 -0.085 3 0.804
TNNI3K_TYRTNNI3K_TYR 0.721 -0.104 1 0.795
MERTKMERTK 0.720 -0.027 3 0.790
FYNFYN 0.720 0.019 -1 0.811
TEKTEK 0.719 -0.110 3 0.765
TECTEC 0.719 -0.055 -1 0.743
FGFR1FGFR1 0.719 -0.110 3 0.788
BMXBMX 0.718 -0.037 -1 0.729
CK1G3CK1G3 0.718 -0.014 -3 0.388
DDR2DDR2 0.718 -0.003 3 0.750
EPHA7EPHA7 0.718 -0.021 2 0.753
FGFR3FGFR3 0.718 -0.033 3 0.779
NTRK1NTRK1 0.717 -0.025 -1 0.862
EPHA3EPHA3 0.717 -0.044 2 0.728
AXLAXL 0.717 -0.086 3 0.798
ALKALK 0.717 -0.083 3 0.738
EPHA5EPHA5 0.716 0.029 2 0.740
PDGFRAPDGFRA 0.716 -0.155 3 0.824
WEE1_TYRWEE1_TYR 0.716 -0.085 -1 0.755
ERBB2ERBB2 0.716 -0.087 1 0.717
PTK6PTK6 0.715 -0.106 -1 0.743
LTKLTK 0.714 -0.080 3 0.751
BTKBTK 0.714 -0.144 -1 0.763
INSRINSR 0.714 -0.062 3 0.751
LYNLYN 0.713 -0.060 3 0.732
MATKMATK 0.713 -0.046 -1 0.768
FLT4FLT4 0.713 -0.084 3 0.758
EGFREGFR 0.712 0.003 1 0.604
FRKFRK 0.712 -0.088 -1 0.843
NTRK2NTRK2 0.712 -0.099 3 0.770
PTK2PTK2 0.711 0.032 -1 0.843
EPHA1EPHA1 0.710 -0.112 3 0.780
NTRK3NTRK3 0.710 -0.044 -1 0.816
FGFR4FGFR4 0.710 0.000 -1 0.812
EPHA8EPHA8 0.709 -0.029 -1 0.856
SYKSYK 0.709 0.038 -1 0.821
SRCSRC 0.705 -0.049 -1 0.811
CSKCSK 0.705 -0.053 2 0.757
IGF1RIGF1R 0.704 -0.001 3 0.691
EPHA2EPHA2 0.704 0.001 -1 0.829
PTK2BPTK2B 0.703 -0.075 -1 0.777
YANK2YANK2 0.699 -0.088 2 0.395
CK1G2CK1G2 0.698 -0.031 -3 0.477
ERBB4ERBB4 0.698 -0.028 1 0.608
MUSKMUSK 0.690 -0.145 1 0.605
ZAP70ZAP70 0.685 -0.030 -1 0.732
FESFES 0.679 -0.105 -1 0.713