Motif 639 (n=168)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0G2JS52 | None | S43 | ochoa | Myelin transcription factor 1 domain-containing protein | None |
A6NDB9 | PALM3 | S544 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
E9PCH4 | None | S1256 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
O00193 | SMAP | S87 | ochoa | Small acidic protein | None |
O00233 | PSMD9 | Y41 | ochoa | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. {ECO:0000269|PubMed:19490896}. |
O15013 | ARHGEF10 | S198 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
O43491 | EPB41L2 | S884 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O43493 | TGOLN2 | S306 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
O43572 | AKAP10 | S202 | ochoa | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
O43583 | DENR | S73 | ochoa|psp | Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) | Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:37875108}. |
O60216 | RAD21 | S138 | ochoa | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
O60271 | SPAG9 | S109 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
O60271 | SPAG9 | S314 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
O60664 | PLIN3 | S130 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
O60669 | SLC16A7 | S454 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
O60934 | NBN | S615 | ochoa|psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
O75363 | BCAS1 | S234 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
O94916 | NFAT5 | S158 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
O95359 | TACC2 | S2250 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
P01833 | PIGR | S708 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
P05060 | CHGB | S146 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
P05067 | APP | S198 | psp | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. |
P06732 | CKM | S164 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
P07237 | P4HB | S427 | ochoa|psp | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
P09874 | PARP1 | S177 | ochoa|psp | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
P10645 | CHGA | S112 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
P12270 | TPR | S1462 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
P20042 | EIF2S2 | S39 | ochoa | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
P20700 | LMNB1 | S534 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
P25440 | BRD2 | S679 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
P25705 | ATP5F1A | S65 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
P29374 | ARID4A | S716 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
P41236 | PPP1R2 | Y114 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
P41970 | ELK3 | S173 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
P46100 | ATRX | S925 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P49321 | NASP | S408 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
P51531 | SMARCA2 | S591 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P51608 | MECP2 | S53 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
P54296 | MYOM2 | S151 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P54296 | MYOM2 | S1392 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P55196 | AFDN | S1262 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
P55884 | EIF3B | S307 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
P61129 | ZC3H6 | S188 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
P98182 | ZNF200 | S182 | ochoa | Zinc finger protein 200 | Localizes protein arginine N-methyltransferase PRMT3 to the nucleus. {ECO:0000269|PubMed:39513743}. |
Q01538 | MYT1 | S335 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
Q01970 | PLCB3 | S537 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
Q05682 | CALD1 | S73 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
Q05682 | CALD1 | S129 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
Q12955 | ANK3 | S4290 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
Q13177 | PAK2 | S42 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
Q14151 | SAFB2 | S82 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14151 | SAFB2 | S194 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14289 | PTK2B | S389 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
Q14839 | CHD4 | S1570 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
Q14839 | CHD4 | S1576 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
Q14980 | NUMA1 | S1149 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q15311 | RALBP1 | S461 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
Q15651 | HMGN3 | S78 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
Q15678 | PTPN14 | S937 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
Q15746 | MYLK | S1438 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
Q15910 | EZH2 | S412 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
Q16891 | IMMT | S356 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
Q32MZ4 | LRRFIP1 | S467 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
Q32MZ4 | LRRFIP1 | S739 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
Q3B820 | FAM161A | S466 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
Q3L8U1 | CHD9 | S1472 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
Q5T0F9 | CC2D1B | S613 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
Q5T200 | ZC3H13 | S1056 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
Q5TAP6 | UTP14C | S301 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
Q5VSL9 | STRIP1 | S65 | ochoa | Striatin-interacting protein 1 (Protein FAM40A) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}. |
Q5VUB5 | FAM171A1 | S381 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
Q68CQ4 | UTP25 | S150 | ochoa | U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) | Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}. |
Q68DK2 | ZFYVE26 | S1893 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
Q69YH5 | CDCA2 | S437 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
Q6IQ55 | TTBK2 | S577 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
Q6NXS1 | PPP1R2B | Y114 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
Q6P3S1 | DENND1B | S711 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
Q6PKG0 | LARP1 | S584 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
Q6PL18 | ATAD2 | S969 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
Q6UXY8 | TMC5 | S967 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
Q6ZMS4 | ZNF852 | S144 | ochoa | Zinc finger protein 852 | May be involved in transcriptional regulation. {ECO:0000250}. |
Q70EL4 | USP43 | S818 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
Q7L3B6 | CDC37L1 | S88 | ochoa | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. |
Q7RTS9 | DYM | S510 | ochoa | Dymeclin (Dyggve-Melchior-Clausen syndrome protein) | Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}. |
Q7Z591 | AKNA | S38 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
Q7Z6J4 | FGD2 | S22 | ochoa | FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}. |
Q86WA8 | LONP2 | S592 | ochoa | Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon) | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}. |
Q86WN1 | FCHSD1 | S435 | ochoa | F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) | Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}. |
Q8IX03 | WWC1 | S651 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
Q8IZT6 | ASPM | S211 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
Q8N163 | CCAR2 | S678 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
Q8N201 | INTS1 | S307 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
Q8N3D4 | EHBP1L1 | S734 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
Q8N3K9 | CMYA5 | S1708 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
Q8N680 | ZBTB2 | S488 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
Q8NC51 | SERBP1 | S252 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
Q8NEC7 | GSTCD | S234 | ochoa | Glutathione S-transferase C-terminal domain-containing protein | None |
Q8NFG4 | FLCN | S302 | ochoa | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
Q8TDY2 | RB1CC1 | S986 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
Q8TEQ6 | GEMIN5 | S765 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
Q8TEU7 | RAPGEF6 | S1206 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
Q8WU20 | FRS2 | S226 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
Q8WU90 | ZC3H15 | S360 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
Q8WUB8 | PHF10 | S67 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
Q8WYB5 | KAT6B | S1303 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
Q92610 | ZNF592 | S298 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
Q92794 | KAT6A | S826 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
Q969F1 | GTF3C6 | S160 | ochoa | General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}. |
Q969G3 | SMARCE1 | S353 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q96A49 | SYAP1 | S313 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
Q96PU5 | NEDD4L | S184 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
Q96Q89 | KIF20B | S1592 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
Q96RL1 | UIMC1 | S171 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
Q96RT1 | ERBIN | S620 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
Q96RU3 | FNBP1 | S527 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
Q96TC7 | RMDN3 | S212 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
Q99081 | TCF12 | S508 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
Q99590 | SCAF11 | S393 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
Q9BRQ6 | CHCHD6 | S126 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
Q9BS91 | SLC35A5 | S402 | ochoa | UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) | Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}. |
Q9BUR4 | WRAP53 | S103 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
Q9BVJ6 | UTP14A | S302 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
Q9BX63 | BRIP1 | S1106 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
Q9BXT4 | TDRD1 | S685 | ochoa | Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}. |
Q9C0C2 | TNKS1BP1 | S1248 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C9 | UBE2O | S429 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
Q9H0E3 | SAP130 | S855 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
Q9H1E3 | NUCKS1 | S58 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
Q9H223 | EHD4 | S482 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
Q9H501 | ESF1 | S190 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
Q9HBG7 | LY9 | S628 | ochoa | T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
Q9NP72 | RAB18 | S144 | ochoa | Ras-related protein Rab-18 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985). {ECO:0000250|UniProtKB:P35293, ECO:0000269|PubMed:21473985, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:30970241}. |
Q9NQX4 | MYO5C | S1113 | ochoa | Unconventional myosin-Vc | May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. |
Q9NSK0 | KLC4 | S163 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
Q9NUA8 | ZBTB40 | S703 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
Q9NUQ6 | SPATS2L | S338 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
Q9NVR5 | DNAAF2 | S787 | ochoa | Protein kintoun (Dynein assembly factor 2, axonemal) | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}. |
Q9NWS9 | ZNF446 | S141 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
Q9NYF8 | BCLAF1 | S181 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
Q9NZ63 | C9orf78 | S101 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
Q9P2R6 | RERE | S40 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
Q9UD71 | PPP1R1B | S94 | ochoa | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | Inhibitor of protein-phosphatase 1. |
Q9UEY8 | ADD3 | S618 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
Q9UKA4 | AKAP11 | S1487 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
Q9UKK3 | PARP4 | S1511 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
Q9ULI0 | ATAD2B | S1314 | ochoa | ATPase family AAA domain-containing protein 2B | None |
Q9UNH7 | SNX6 | S194 | ochoa | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
Q9UPV0 | CEP164 | S487 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
Q9UPZ3 | HPS5 | S695 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
Q9Y2H5 | PLEKHA6 | S961 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y2M0 | FAN1 | S209 | ochoa | Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}. |
Q9Y365 | STARD10 | S246 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
Q9Y487 | ATP6V0A2 | S704 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
Q9Y520 | PRRC2C | S633 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
Q9Y520 | PRRC2C | S1100 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
P08238 | HSP90AB1 | S474 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
Q12802 | AKAP13 | S906 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
Q92888 | ARHGEF1 | S409 | Sugiyama | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
Q92785 | DPF2 | S251 | EPSD | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
Q1KMD3 | HNRNPUL2 | Y215 | Sugiyama | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
P16949 | STMN1 | S94 | Sugiyama | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
O00625 | PIR | S225 | Sugiyama | Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase) | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:15951572, ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}. |
Q13224 | GRIN2B | S383 | iPTMNet | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
O43290 | SART1 | S117 | Sugiyama | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
P11586 | MTHFD1 | S771 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
P12270 | TPR | S1241 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
Q8TDX7 | NEK7 | S260 | Sugiyama | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:31409757, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}. |
Q9Y5S2 | CDC42BPB | S437 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000237 | 3.626 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.000185 | 3.732 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000469 | 3.329 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.000416 | 3.380 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.000416 | 3.380 |
R-HSA-4839726 | Chromatin organization | 0.000218 | 3.661 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000911 | 3.040 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000975 | 3.011 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.001097 | 2.960 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.001097 | 2.960 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.001280 | 2.893 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.001448 | 2.839 |
R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.002071 | 2.684 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.002162 | 2.665 |
R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.002798 | 2.553 |
R-HSA-9020591 | Interleukin-12 signaling | 0.002518 | 2.599 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003629 | 2.440 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.004616 | 2.336 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.004616 | 2.336 |
R-HSA-447115 | Interleukin-12 family signaling | 0.004421 | 2.354 |
R-HSA-9022707 | MECP2 regulates transcription factors | 0.005589 | 2.253 |
R-HSA-8949613 | Cristae formation | 0.005998 | 2.222 |
R-HSA-193648 | NRAGE signals death through JNK | 0.005722 | 2.242 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.005998 | 2.222 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.007051 | 2.152 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.009244 | 2.034 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.008980 | 2.047 |
R-HSA-9005895 | Pervasive developmental disorders | 0.013705 | 1.863 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.013705 | 1.863 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.013705 | 1.863 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.012730 | 1.895 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.015362 | 1.814 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.015515 | 1.809 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.021745 | 1.663 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.021745 | 1.663 |
R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.021745 | 1.663 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.021745 | 1.663 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.021745 | 1.663 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.021745 | 1.663 |
R-HSA-5602566 | TICAM1 deficiency - HSE | 0.021745 | 1.663 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.018917 | 1.723 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.022783 | 1.642 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.021206 | 1.674 |
R-HSA-9645723 | Diseases of programmed cell death | 0.022913 | 1.640 |
R-HSA-5602571 | TRAF3 deficiency - HSE | 0.032440 | 1.489 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.043020 | 1.366 |
R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.043020 | 1.366 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.043020 | 1.366 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.043020 | 1.366 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.043020 | 1.366 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.043020 | 1.366 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.043020 | 1.366 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.043020 | 1.366 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.043020 | 1.366 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.043020 | 1.366 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.043020 | 1.366 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.043020 | 1.366 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.029130 | 1.536 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.031385 | 1.503 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.031385 | 1.503 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.031385 | 1.503 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.031385 | 1.503 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.033075 | 1.480 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.026943 | 1.570 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.035600 | 1.449 |
R-HSA-844456 | The NLRP3 inflammasome | 0.029130 | 1.536 |
R-HSA-445355 | Smooth Muscle Contraction | 0.030361 | 1.518 |
R-HSA-352238 | Breakdown of the nuclear lamina | 0.032440 | 1.489 |
R-HSA-983189 | Kinesins | 0.039815 | 1.400 |
R-HSA-3214847 | HATs acetylate histones | 0.034024 | 1.468 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.035034 | 1.456 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.036963 | 1.432 |
R-HSA-1640170 | Cell Cycle | 0.031186 | 1.506 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.034024 | 1.468 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.043267 | 1.364 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.043267 | 1.364 |
R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.063834 | 1.195 |
R-HSA-2562578 | TRIF-mediated programmed cell death | 0.104122 | 0.982 |
R-HSA-72731 | Recycling of eIF2:GDP | 0.104122 | 0.982 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.104122 | 0.982 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.113922 | 0.943 |
R-HSA-9613354 | Lipophagy | 0.123615 | 0.908 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.133203 | 0.875 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.133203 | 0.875 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.152066 | 0.818 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.046254 | 1.335 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.057325 | 1.242 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.188577 | 0.725 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.188577 | 0.725 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.078601 | 1.105 |
R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.223525 | 0.651 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.232025 | 0.634 |
R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.240433 | 0.619 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.119559 | 0.922 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.256975 | 0.590 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.256975 | 0.590 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.256975 | 0.590 |
R-HSA-1221632 | Meiotic synapsis | 0.145402 | 0.837 |
R-HSA-72649 | Translation initiation complex formation | 0.149184 | 0.826 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.156806 | 0.805 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.304483 | 0.516 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.168373 | 0.774 |
R-HSA-191859 | snRNP Assembly | 0.168373 | 0.774 |
R-HSA-9615710 | Late endosomal microautophagy | 0.319638 | 0.495 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.327091 | 0.485 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.334464 | 0.476 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.334464 | 0.476 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.334464 | 0.476 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.348969 | 0.457 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.348969 | 0.457 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.288650 | 0.540 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.075837 | 1.120 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.152066 | 0.818 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.206242 | 0.686 |
R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.232025 | 0.634 |
R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.240433 | 0.619 |
R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.265112 | 0.577 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.288993 | 0.539 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.265112 | 0.577 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.152066 | 0.818 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.256975 | 0.590 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.265112 | 0.577 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.288993 | 0.539 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.312102 | 0.506 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.296740 | 0.528 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.161345 | 0.792 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.199848 | 0.699 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.168373 | 0.774 |
R-HSA-5693538 | Homology Directed Repair | 0.058872 | 1.230 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.161345 | 0.792 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.348969 | 0.457 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.312102 | 0.506 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.120814 | 0.918 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.162297 | 0.790 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.069209 | 1.160 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.072296 | 1.141 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.327091 | 0.485 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.074072 | 1.130 |
R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.084199 | 1.075 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.069209 | 1.160 |
R-HSA-180024 | DARPP-32 events | 0.319638 | 0.495 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.145402 | 0.837 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.344395 | 0.463 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.319638 | 0.495 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.327091 | 0.485 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.075428 | 1.122 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.199848 | 0.699 |
R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.094215 | 1.026 |
R-HSA-69478 | G2/M DNA replication checkpoint | 0.094215 | 1.026 |
R-HSA-192814 | vRNA Synthesis | 0.142686 | 0.846 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.152066 | 0.818 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.152066 | 0.818 |
R-HSA-525793 | Myogenesis | 0.048940 | 1.310 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.161345 | 0.792 |
R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.161345 | 0.792 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.170522 | 0.768 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.170522 | 0.768 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.072296 | 1.141 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.075428 | 1.122 |
R-HSA-500657 | Presynaptic function of Kainate receptors | 0.223525 | 0.651 |
R-HSA-1500620 | Meiosis | 0.083902 | 1.076 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.180081 | 0.745 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.334464 | 0.476 |
R-HSA-68877 | Mitotic Prometaphase | 0.205914 | 0.686 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 0.179599 | 0.746 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.288993 | 0.539 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.101904 | 0.992 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.280549 | 0.552 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.223525 | 0.651 |
R-HSA-9620244 | Long-term potentiation | 0.288993 | 0.539 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.327091 | 0.485 |
R-HSA-8963888 | Chylomicron assembly | 0.142686 | 0.846 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.088366 | 1.054 |
R-HSA-3214815 | HDACs deacetylate histones | 0.152985 | 0.815 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.341756 | 0.466 |
R-HSA-170968 | Frs2-mediated activation | 0.170522 | 0.768 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 0.223525 | 0.651 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.227909 | 0.642 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.316900 | 0.499 |
R-HSA-8964041 | LDL remodeling | 0.104122 | 0.982 |
R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.113922 | 0.943 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.142686 | 0.846 |
R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.197458 | 0.705 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.223525 | 0.651 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.223525 | 0.651 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.164501 | 0.784 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 0.304483 | 0.516 |
R-HSA-77387 | Insulin receptor recycling | 0.312102 | 0.506 |
R-HSA-157579 | Telomere Maintenance | 0.332935 | 0.478 |
R-HSA-68886 | M Phase | 0.157539 | 0.803 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.059050 | 1.229 |
R-HSA-6794361 | Neurexins and neuroligins | 0.141640 | 0.849 |
R-HSA-3371556 | Cellular response to heat stress | 0.186574 | 0.729 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.126820 | 0.897 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.281119 | 0.551 |
R-HSA-73894 | DNA Repair | 0.241471 | 0.617 |
R-HSA-9612973 | Autophagy | 0.299541 | 0.524 |
R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.113922 | 0.943 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.069209 | 1.160 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.078601 | 1.105 |
R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.206242 | 0.686 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.240433 | 0.619 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.348969 | 0.457 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.352826 | 0.452 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.081651 | 1.088 |
R-HSA-3928664 | Ephrin signaling | 0.223525 | 0.651 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.272442 | 0.565 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.223525 | 0.651 |
R-HSA-169893 | Prolonged ERK activation events | 0.197458 | 0.705 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.296780 | 0.528 |
R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.133203 | 0.875 |
R-HSA-428540 | Activation of RAC1 | 0.152066 | 0.818 |
R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.152066 | 0.818 |
R-HSA-622312 | Inflammasomes | 0.054477 | 1.264 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.188577 | 0.725 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.256975 | 0.590 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.062612 | 1.203 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.273159 | 0.564 |
R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.273159 | 0.564 |
R-HSA-429947 | Deadenylation of mRNA | 0.281119 | 0.551 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.281119 | 0.551 |
R-HSA-9839394 | TGFBR3 expression | 0.288993 | 0.539 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.252170 | 0.598 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.348969 | 0.457 |
R-HSA-68875 | Mitotic Prophase | 0.061506 | 1.211 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.319638 | 0.495 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.319638 | 0.495 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.119559 | 0.922 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.119559 | 0.922 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.312102 | 0.506 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.319638 | 0.495 |
R-HSA-164944 | Nef and signal transduction | 0.094215 | 1.026 |
R-HSA-8866423 | VLDL assembly | 0.094215 | 1.026 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.104122 | 0.982 |
R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.123615 | 0.908 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.179599 | 0.746 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.069209 | 1.160 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.123176 | 0.909 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.172261 | 0.764 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.348969 | 0.457 |
R-HSA-199991 | Membrane Trafficking | 0.120891 | 0.918 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.276496 | 0.558 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.082944 | 1.081 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.051682 | 1.287 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.114787 | 0.940 |
R-HSA-1474165 | Reproduction | 0.217412 | 0.663 |
R-HSA-9840373 | Cellular response to mitochondrial stress | 0.123615 | 0.908 |
R-HSA-389359 | CD28 dependent Vav1 pathway | 0.170522 | 0.768 |
R-HSA-71288 | Creatine metabolism | 0.240433 | 0.619 |
R-HSA-5689901 | Metalloprotease DUBs | 0.296780 | 0.528 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.312102 | 0.506 |
R-HSA-69481 | G2/M Checkpoints | 0.072658 | 1.139 |
R-HSA-5653656 | Vesicle-mediated transport | 0.304509 | 0.516 |
R-HSA-9031628 | NGF-stimulated transcription | 0.126820 | 0.897 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.281119 | 0.551 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.187953 | 0.726 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.066166 | 1.179 |
R-HSA-9675135 | Diseases of DNA repair | 0.119559 | 0.922 |
R-HSA-2559583 | Cellular Senescence | 0.177172 | 0.752 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.256975 | 0.590 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.265112 | 0.577 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.327091 | 0.485 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.308850 | 0.510 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.162213 | 0.790 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.199358 | 0.700 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.112407 | 0.949 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.348969 | 0.457 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.044271 | 1.354 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.219856 | 0.658 |
R-HSA-373755 | Semaphorin interactions | 0.184011 | 0.735 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.172261 | 0.764 |
R-HSA-264876 | Insulin processing | 0.304483 | 0.516 |
R-HSA-74160 | Gene expression (Transcription) | 0.102097 | 0.991 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.166510 | 0.779 |
R-HSA-9609507 | Protein localization | 0.290596 | 0.537 |
R-HSA-9683610 | Maturation of nucleoprotein | 0.170522 | 0.768 |
R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.197458 | 0.705 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.327091 | 0.485 |
R-HSA-166520 | Signaling by NTRKs | 0.111700 | 0.952 |
R-HSA-212436 | Generic Transcription Pathway | 0.204735 | 0.689 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.208892 | 0.680 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.184934 | 0.733 |
R-HSA-9020558 | Interleukin-2 signaling | 0.142686 | 0.846 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.178106 | 0.749 |
R-HSA-391160 | Signal regulatory protein family interactions | 0.179599 | 0.746 |
R-HSA-9629569 | Protein hydroxylation | 0.240433 | 0.619 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.352826 | 0.452 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.060223 | 1.220 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.223525 | 0.651 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.281119 | 0.551 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.211829 | 0.674 |
R-HSA-74752 | Signaling by Insulin receptor | 0.308850 | 0.510 |
R-HSA-75153 | Apoptotic execution phase | 0.119559 | 0.922 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.258017 | 0.588 |
R-HSA-9020933 | Interleukin-23 signaling | 0.113922 | 0.943 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.057577 | 1.240 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.348969 | 0.457 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.211829 | 0.674 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.332935 | 0.478 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.156806 | 0.805 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.353356 | 0.452 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.353356 | 0.452 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.291160 | 0.536 |
R-HSA-9008059 | Interleukin-37 signaling | 0.060223 | 1.220 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.232025 | 0.634 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.265112 | 0.577 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.052556 | 1.279 |
R-HSA-109581 | Apoptosis | 0.317472 | 0.498 |
R-HSA-9006936 | Signaling by TGFB family members | 0.311491 | 0.507 |
R-HSA-156711 | Polo-like kinase mediated events | 0.223525 | 0.651 |
R-HSA-418990 | Adherens junctions interactions | 0.266861 | 0.574 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.126820 | 0.897 |
R-HSA-421270 | Cell-cell junction organization | 0.347964 | 0.458 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.095065 | 1.022 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.296780 | 0.528 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.348969 | 0.457 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.320918 | 0.494 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.206242 | 0.686 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.281671 | 0.550 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.152985 | 0.815 |
R-HSA-1500931 | Cell-Cell communication | 0.310838 | 0.507 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.284600 | 0.546 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.134091 | 0.873 |
R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.273159 | 0.564 |
R-HSA-9694635 | Translation of Structural Proteins | 0.240024 | 0.620 |
R-HSA-1236394 | Signaling by ERBB4 | 0.227909 | 0.642 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.280549 | 0.552 |
R-HSA-391251 | Protein folding | 0.308850 | 0.510 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.281671 | 0.550 |
R-HSA-2028269 | Signaling by Hippo | 0.214931 | 0.668 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.221924 | 0.654 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.308850 | 0.510 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.341756 | 0.466 |
R-HSA-9679506 | SARS-CoV Infections | 0.300956 | 0.521 |
R-HSA-446652 | Interleukin-1 family signaling | 0.287618 | 0.541 |
R-HSA-449147 | Signaling by Interleukins | 0.101414 | 0.994 |
R-HSA-73887 | Death Receptor Signaling | 0.122674 | 0.911 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.356103 | 0.448 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.356103 | 0.448 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.356103 | 0.448 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.356103 | 0.448 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.356103 | 0.448 |
R-HSA-111885 | Opioid Signalling | 0.360726 | 0.443 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.363160 | 0.440 |
R-HSA-180746 | Nuclear import of Rev protein | 0.363160 | 0.440 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.363160 | 0.440 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.363160 | 0.440 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.365350 | 0.437 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.368591 | 0.433 |
R-HSA-169911 | Regulation of Apoptosis | 0.370139 | 0.432 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.370139 | 0.432 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.370139 | 0.432 |
R-HSA-381042 | PERK regulates gene expression | 0.370139 | 0.432 |
R-HSA-917977 | Transferrin endocytosis and recycling | 0.370139 | 0.432 |
R-HSA-187687 | Signalling to ERKs | 0.370139 | 0.432 |
R-HSA-211000 | Gene Silencing by RNA | 0.376418 | 0.424 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.377043 | 0.424 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.377043 | 0.424 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.377043 | 0.424 |
R-HSA-3371511 | HSF1 activation | 0.377043 | 0.424 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.377043 | 0.424 |
R-HSA-163560 | Triglyceride catabolism | 0.377043 | 0.424 |
R-HSA-8853659 | RET signaling | 0.377043 | 0.424 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.380317 | 0.420 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.380317 | 0.420 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.380317 | 0.420 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.383871 | 0.416 |
R-HSA-196757 | Metabolism of folate and pterines | 0.383871 | 0.416 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.384205 | 0.415 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.388084 | 0.411 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.388084 | 0.411 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.390625 | 0.408 |
R-HSA-69275 | G2/M Transition | 0.391974 | 0.407 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.395808 | 0.403 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.397305 | 0.401 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.397305 | 0.401 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.397305 | 0.401 |
R-HSA-201556 | Signaling by ALK | 0.397305 | 0.401 |
R-HSA-9648002 | RAS processing | 0.397305 | 0.401 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.397305 | 0.401 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.397305 | 0.401 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.397870 | 0.400 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.397870 | 0.400 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.399653 | 0.398 |
R-HSA-5617833 | Cilium Assembly | 0.403751 | 0.394 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.403912 | 0.394 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.403912 | 0.394 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.403912 | 0.394 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.403912 | 0.394 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.403912 | 0.394 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.403912 | 0.394 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.403912 | 0.394 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.403912 | 0.394 |
R-HSA-3371568 | Attenuation phase | 0.403912 | 0.394 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.403912 | 0.394 |
R-HSA-5260271 | Diseases of Immune System | 0.403912 | 0.394 |
R-HSA-202433 | Generation of second messenger molecules | 0.403912 | 0.394 |
R-HSA-451927 | Interleukin-2 family signaling | 0.403912 | 0.394 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.410447 | 0.387 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.410447 | 0.387 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.410447 | 0.387 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.410447 | 0.387 |
R-HSA-9694548 | Maturation of spike protein | 0.410447 | 0.387 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.410447 | 0.387 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.410447 | 0.387 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.411121 | 0.386 |
R-HSA-446728 | Cell junction organization | 0.414819 | 0.382 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.414920 | 0.382 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.415465 | 0.381 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.416912 | 0.380 |
R-HSA-9683701 | Translation of Structural Proteins | 0.416912 | 0.380 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.417275 | 0.380 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.418707 | 0.378 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.418707 | 0.378 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.421294 | 0.375 |
R-HSA-9007101 | Rab regulation of trafficking | 0.422481 | 0.374 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.423305 | 0.373 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.428247 | 0.368 |
R-HSA-5654743 | Signaling by FGFR4 | 0.429629 | 0.367 |
R-HSA-9710421 | Defective pyroptosis | 0.429629 | 0.367 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.429629 | 0.367 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.435884 | 0.361 |
R-HSA-9907900 | Proteasome assembly | 0.435884 | 0.361 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.435884 | 0.361 |
R-HSA-73886 | Chromosome Maintenance | 0.437452 | 0.359 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.442071 | 0.355 |
R-HSA-5654741 | Signaling by FGFR3 | 0.442071 | 0.355 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.442071 | 0.355 |
R-HSA-2132295 | MHC class II antigen presentation | 0.444858 | 0.352 |
R-HSA-72172 | mRNA Splicing | 0.447277 | 0.349 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.448190 | 0.349 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.448190 | 0.349 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.448190 | 0.349 |
R-HSA-162909 | Host Interactions of HIV factors | 0.448542 | 0.348 |
R-HSA-5357801 | Programmed Cell Death | 0.450137 | 0.347 |
R-HSA-1483191 | Synthesis of PC | 0.454242 | 0.343 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.454242 | 0.343 |
R-HSA-194138 | Signaling by VEGF | 0.455867 | 0.341 |
R-HSA-5620924 | Intraflagellar transport | 0.460229 | 0.337 |
R-HSA-389356 | Co-stimulation by CD28 | 0.460229 | 0.337 |
R-HSA-8963899 | Plasma lipoprotein remodeling | 0.460229 | 0.337 |
R-HSA-114608 | Platelet degranulation | 0.463137 | 0.334 |
R-HSA-73893 | DNA Damage Bypass | 0.466150 | 0.331 |
R-HSA-397014 | Muscle contraction | 0.469981 | 0.328 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.472007 | 0.326 |
R-HSA-109704 | PI3K Cascade | 0.472007 | 0.326 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.472790 | 0.325 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.477799 | 0.321 |
R-HSA-912446 | Meiotic recombination | 0.477799 | 0.321 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.477799 | 0.321 |
R-HSA-9843745 | Adipogenesis | 0.481060 | 0.318 |
R-HSA-68882 | Mitotic Anaphase | 0.481178 | 0.318 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.483529 | 0.316 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.483960 | 0.315 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.488127 | 0.311 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.489196 | 0.311 |
R-HSA-162582 | Signal Transduction | 0.493098 | 0.307 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.494801 | 0.306 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.500345 | 0.301 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.502079 | 0.299 |
R-HSA-5654736 | Signaling by FGFR1 | 0.505829 | 0.296 |
R-HSA-8935690 | Digestion | 0.505829 | 0.296 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.505829 | 0.296 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.508673 | 0.294 |
R-HSA-112399 | IRS-mediated signalling | 0.511252 | 0.291 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.511252 | 0.291 |
R-HSA-162906 | HIV Infection | 0.511382 | 0.291 |
R-HSA-6807070 | PTEN Regulation | 0.512383 | 0.290 |
R-HSA-1632852 | Macroautophagy | 0.519175 | 0.285 |
R-HSA-180786 | Extension of Telomeres | 0.521923 | 0.282 |
R-HSA-9033241 | Peroxisomal protein import | 0.521923 | 0.282 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.521923 | 0.282 |
R-HSA-8979227 | Triglyceride metabolism | 0.521923 | 0.282 |
R-HSA-72312 | rRNA processing | 0.524805 | 0.280 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.525904 | 0.279 |
R-HSA-8873719 | RAB geranylgeranylation | 0.527171 | 0.278 |
R-HSA-1227986 | Signaling by ERBB2 | 0.527171 | 0.278 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.529244 | 0.276 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.532361 | 0.274 |
R-HSA-112043 | PLC beta mediated events | 0.532361 | 0.274 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.532361 | 0.274 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.537496 | 0.270 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.537496 | 0.270 |
R-HSA-1268020 | Mitochondrial protein import | 0.537496 | 0.270 |
R-HSA-9707616 | Heme signaling | 0.537496 | 0.270 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.537496 | 0.270 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.539221 | 0.268 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.542574 | 0.266 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.542574 | 0.266 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.542574 | 0.266 |
R-HSA-8963743 | Digestion and absorption | 0.542574 | 0.266 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.545708 | 0.263 |
R-HSA-2428924 | IGF1R signaling cascade | 0.547596 | 0.262 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.547596 | 0.262 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.552564 | 0.258 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.557477 | 0.254 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.557477 | 0.254 |
R-HSA-112040 | G-protein mediated events | 0.562337 | 0.250 |
R-HSA-196807 | Nicotinate metabolism | 0.562337 | 0.250 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.564933 | 0.248 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.567144 | 0.246 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.567144 | 0.246 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.568080 | 0.246 |
R-HSA-162587 | HIV Life Cycle | 0.574325 | 0.241 |
R-HSA-5683057 | MAPK family signaling cascades | 0.575449 | 0.240 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.576600 | 0.239 |
R-HSA-9711097 | Cellular response to starvation | 0.577423 | 0.239 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.581251 | 0.236 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.581251 | 0.236 |
R-HSA-3000178 | ECM proteoglycans | 0.581251 | 0.236 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.585852 | 0.232 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.590401 | 0.229 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.590401 | 0.229 |
R-HSA-4086398 | Ca2+ pathway | 0.590401 | 0.229 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.590401 | 0.229 |
R-HSA-2262752 | Cellular responses to stress | 0.594675 | 0.226 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 0.594902 | 0.226 |
R-HSA-380287 | Centrosome maturation | 0.599353 | 0.222 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.599353 | 0.222 |
R-HSA-917937 | Iron uptake and transport | 0.599353 | 0.222 |
R-HSA-8953854 | Metabolism of RNA | 0.601709 | 0.221 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.603755 | 0.219 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.612416 | 0.213 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 0.612416 | 0.213 |
R-HSA-9824446 | Viral Infection Pathways | 0.613484 | 0.212 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.616676 | 0.210 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.620681 | 0.207 |
R-HSA-5654738 | Signaling by FGFR2 | 0.620889 | 0.207 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.620889 | 0.207 |
R-HSA-9833482 | PKR-mediated signaling | 0.620889 | 0.207 |
R-HSA-977225 | Amyloid fiber formation | 0.625056 | 0.204 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.625056 | 0.204 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.629177 | 0.201 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.633254 | 0.198 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.637286 | 0.196 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.637286 | 0.196 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.637286 | 0.196 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.641274 | 0.193 |
R-HSA-168255 | Influenza Infection | 0.641428 | 0.193 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.649119 | 0.188 |
R-HSA-438064 | Post NMDA receptor activation events | 0.652977 | 0.185 |
R-HSA-9663891 | Selective autophagy | 0.656794 | 0.183 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.662188 | 0.179 |
R-HSA-73884 | Base Excision Repair | 0.664301 | 0.178 |
R-HSA-983712 | Ion channel transport | 0.667912 | 0.175 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.673017 | 0.172 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.674857 | 0.171 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.675258 | 0.171 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.675546 | 0.170 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.676934 | 0.169 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.682364 | 0.166 |
R-HSA-1474290 | Collagen formation | 0.682364 | 0.166 |
R-HSA-9609690 | HCMV Early Events | 0.685502 | 0.164 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.689315 | 0.162 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.692734 | 0.159 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.692734 | 0.159 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.692734 | 0.159 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.696115 | 0.157 |
R-HSA-190236 | Signaling by FGFR | 0.699460 | 0.155 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.699460 | 0.155 |
R-HSA-422356 | Regulation of insulin secretion | 0.699460 | 0.155 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.699460 | 0.155 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.699460 | 0.155 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.699460 | 0.155 |
R-HSA-70171 | Glycolysis | 0.706039 | 0.151 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.706039 | 0.151 |
R-HSA-9020702 | Interleukin-1 signaling | 0.709275 | 0.149 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.712475 | 0.147 |
R-HSA-1483255 | PI Metabolism | 0.712475 | 0.147 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.715640 | 0.145 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.718771 | 0.143 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.718771 | 0.143 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.721867 | 0.142 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.721867 | 0.142 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.724930 | 0.140 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.725064 | 0.140 |
R-HSA-2672351 | Stimuli-sensing channels | 0.733917 | 0.134 |
R-HSA-5419276 | Mitochondrial translation termination | 0.736848 | 0.133 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.736848 | 0.133 |
R-HSA-202403 | TCR signaling | 0.739746 | 0.131 |
R-HSA-8953897 | Cellular responses to stimuli | 0.741709 | 0.130 |
R-HSA-6803157 | Antimicrobial peptides | 0.742613 | 0.129 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.745448 | 0.128 |
R-HSA-422475 | Axon guidance | 0.748400 | 0.126 |
R-HSA-373760 | L1CAM interactions | 0.761819 | 0.118 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.762130 | 0.118 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.762310 | 0.118 |
R-HSA-70326 | Glucose metabolism | 0.764444 | 0.117 |
R-HSA-2980736 | Peptide hormone metabolism | 0.764444 | 0.117 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.767040 | 0.115 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.769608 | 0.114 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.769608 | 0.114 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.774659 | 0.111 |
R-HSA-388396 | GPCR downstream signalling | 0.775205 | 0.111 |
R-HSA-8939211 | ESR-mediated signaling | 0.775578 | 0.110 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.777143 | 0.109 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.777143 | 0.109 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.779600 | 0.108 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.779600 | 0.108 |
R-HSA-157118 | Signaling by NOTCH | 0.781065 | 0.107 |
R-HSA-9675108 | Nervous system development | 0.795611 | 0.099 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.798310 | 0.098 |
R-HSA-9609646 | HCMV Infection | 0.798518 | 0.098 |
R-HSA-9909396 | Circadian clock | 0.804911 | 0.094 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.808391 | 0.092 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.815439 | 0.089 |
R-HSA-163685 | Integration of energy metabolism | 0.815439 | 0.089 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.817476 | 0.088 |
R-HSA-5368287 | Mitochondrial translation | 0.819491 | 0.086 |
R-HSA-5358351 | Signaling by Hedgehog | 0.819491 | 0.086 |
R-HSA-416476 | G alpha (q) signalling events | 0.820889 | 0.086 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.821483 | 0.085 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.825402 | 0.083 |
R-HSA-9711123 | Cellular response to chemical stress | 0.826861 | 0.083 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.835486 | 0.078 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.838458 | 0.077 |
R-HSA-69242 | S Phase | 0.840243 | 0.076 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.845059 | 0.073 |
R-HSA-9658195 | Leishmania infection | 0.845059 | 0.073 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.846385 | 0.072 |
R-HSA-418594 | G alpha (i) signalling events | 0.851776 | 0.070 |
R-HSA-1989781 | PPARA activates gene expression | 0.852195 | 0.069 |
R-HSA-372790 | Signaling by GPCR | 0.853581 | 0.069 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.855443 | 0.068 |
R-HSA-9610379 | HCMV Late Events | 0.855443 | 0.068 |
R-HSA-1483257 | Phospholipid metabolism | 0.862710 | 0.064 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.866264 | 0.062 |
R-HSA-5619102 | SLC transporter disorders | 0.870651 | 0.060 |
R-HSA-72766 | Translation | 0.874355 | 0.058 |
R-HSA-72306 | tRNA processing | 0.876279 | 0.057 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.877648 | 0.057 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.879001 | 0.056 |
R-HSA-109582 | Hemostasis | 0.881115 | 0.055 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.881663 | 0.055 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.882973 | 0.054 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.892629 | 0.049 |
R-HSA-168256 | Immune System | 0.893244 | 0.049 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.896457 | 0.047 |
R-HSA-6798695 | Neutrophil degranulation | 0.898680 | 0.046 |
R-HSA-1474244 | Extracellular matrix organization | 0.900000 | 0.046 |
R-HSA-112316 | Neuronal System | 0.907024 | 0.042 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.911408 | 0.040 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.913360 | 0.039 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.914321 | 0.039 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.914321 | 0.039 |
R-HSA-376176 | Signaling by ROBO receptors | 0.914321 | 0.039 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.925030 | 0.034 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.925708 | 0.034 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.938124 | 0.028 |
R-HSA-913531 | Interferon Signaling | 0.938124 | 0.028 |
R-HSA-1643685 | Disease | 0.943401 | 0.025 |
R-HSA-5663205 | Infectious disease | 0.944667 | 0.025 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.948150 | 0.023 |
R-HSA-5688426 | Deubiquitination | 0.952586 | 0.021 |
R-HSA-392499 | Metabolism of proteins | 0.962626 | 0.017 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.963346 | 0.016 |
R-HSA-597592 | Post-translational protein modification | 0.963430 | 0.016 |
R-HSA-168249 | Innate Immune System | 0.965252 | 0.015 |
R-HSA-382551 | Transport of small molecules | 0.966912 | 0.015 |
R-HSA-195721 | Signaling by WNT | 0.970705 | 0.013 |
R-HSA-1266738 | Developmental Biology | 0.974759 | 0.011 |
R-HSA-8957322 | Metabolism of steroids | 0.978119 | 0.010 |
R-HSA-1280218 | Adaptive Immune System | 0.979168 | 0.009 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.981924 | 0.008 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.989707 | 0.004 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990161 | 0.004 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.990488 | 0.004 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.992828 | 0.003 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995063 | 0.002 |
R-HSA-211859 | Biological oxidations | 0.997718 | 0.001 |
R-HSA-500792 | GPCR ligand binding | 0.998925 | 0.000 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999228 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999967 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.840 | 0.204 | 2 | 0.873 |
CLK3 |
0.830 | 0.162 | 1 | 0.810 |
DSTYK |
0.820 | 0.097 | 2 | 0.880 |
KIS |
0.819 | 0.107 | 1 | 0.694 |
MOS |
0.818 | 0.041 | 1 | 0.834 |
PIM3 |
0.817 | 0.039 | -3 | 0.767 |
NDR2 |
0.817 | 0.043 | -3 | 0.766 |
NEK6 |
0.816 | 0.041 | -2 | 0.860 |
GCN2 |
0.816 | -0.029 | 2 | 0.804 |
RAF1 |
0.816 | 0.016 | 1 | 0.828 |
IKKB |
0.815 | 0.033 | -2 | 0.705 |
CDC7 |
0.815 | -0.027 | 1 | 0.791 |
ATR |
0.813 | 0.068 | 1 | 0.859 |
PRKD1 |
0.813 | 0.077 | -3 | 0.727 |
PRPK |
0.813 | -0.029 | -1 | 0.861 |
CAMK2G |
0.813 | 0.087 | 2 | 0.829 |
TGFBR2 |
0.812 | 0.062 | -2 | 0.862 |
NEK7 |
0.812 | 0.018 | -3 | 0.808 |
TBK1 |
0.811 | 0.003 | 1 | 0.740 |
GRK1 |
0.811 | 0.117 | -2 | 0.726 |
PIM1 |
0.811 | 0.074 | -3 | 0.712 |
BMPR2 |
0.811 | 0.044 | -2 | 0.871 |
CAMK1B |
0.811 | 0.012 | -3 | 0.783 |
IKKA |
0.811 | 0.084 | -2 | 0.702 |
ATM |
0.811 | 0.130 | 1 | 0.814 |
PRKD2 |
0.810 | 0.059 | -3 | 0.683 |
IKKE |
0.810 | 0.011 | 1 | 0.745 |
MTOR |
0.810 | -0.061 | 1 | 0.776 |
SRPK1 |
0.809 | 0.046 | -3 | 0.684 |
SKMLCK |
0.808 | 0.061 | -2 | 0.823 |
NLK |
0.808 | -0.021 | 1 | 0.819 |
LATS2 |
0.807 | 0.059 | -5 | 0.733 |
FAM20C |
0.807 | 0.093 | 2 | 0.613 |
PKN3 |
0.807 | -0.003 | -3 | 0.739 |
ULK2 |
0.807 | -0.086 | 2 | 0.786 |
CAMK2B |
0.806 | 0.123 | 2 | 0.804 |
BMPR1B |
0.806 | 0.156 | 1 | 0.700 |
CDKL1 |
0.806 | -0.010 | -3 | 0.733 |
RSK2 |
0.805 | 0.029 | -3 | 0.697 |
PDHK4 |
0.804 | -0.159 | 1 | 0.837 |
NDR1 |
0.804 | -0.021 | -3 | 0.752 |
GRK6 |
0.804 | 0.070 | 1 | 0.770 |
CHAK2 |
0.803 | 0.014 | -1 | 0.865 |
PKCD |
0.803 | 0.018 | 2 | 0.807 |
MLK1 |
0.803 | -0.046 | 2 | 0.820 |
TGFBR1 |
0.803 | 0.179 | -2 | 0.869 |
LATS1 |
0.803 | 0.115 | -3 | 0.781 |
HIPK4 |
0.803 | 0.006 | 1 | 0.821 |
CAMLCK |
0.803 | 0.007 | -2 | 0.826 |
MAPKAPK2 |
0.802 | 0.061 | -3 | 0.656 |
BCKDK |
0.802 | -0.024 | -1 | 0.849 |
PDHK1 |
0.802 | -0.102 | 1 | 0.840 |
NIK |
0.802 | -0.051 | -3 | 0.798 |
MST4 |
0.802 | -0.020 | 2 | 0.866 |
ERK5 |
0.802 | -0.013 | 1 | 0.762 |
NUAK2 |
0.801 | -0.048 | -3 | 0.764 |
WNK1 |
0.801 | -0.043 | -2 | 0.808 |
CAMK2D |
0.801 | 0.027 | -3 | 0.745 |
SRPK2 |
0.801 | 0.033 | -3 | 0.611 |
GRK5 |
0.800 | -0.062 | -3 | 0.792 |
PKN2 |
0.800 | -0.029 | -3 | 0.749 |
P90RSK |
0.799 | -0.001 | -3 | 0.699 |
CAMK2A |
0.799 | 0.070 | 2 | 0.822 |
TSSK2 |
0.799 | 0.001 | -5 | 0.852 |
RIPK3 |
0.799 | -0.092 | 3 | 0.758 |
AMPKA1 |
0.799 | -0.052 | -3 | 0.763 |
TSSK1 |
0.799 | -0.009 | -3 | 0.776 |
ULK1 |
0.799 | -0.071 | -3 | 0.756 |
PLK1 |
0.799 | 0.077 | -2 | 0.843 |
MARK4 |
0.799 | -0.075 | 4 | 0.471 |
ALK4 |
0.798 | 0.129 | -2 | 0.881 |
GRK4 |
0.798 | 0.011 | -2 | 0.793 |
HUNK |
0.798 | -0.060 | 2 | 0.792 |
NEK9 |
0.798 | -0.048 | 2 | 0.835 |
ALK2 |
0.798 | 0.198 | -2 | 0.866 |
DAPK2 |
0.798 | -0.041 | -3 | 0.785 |
ICK |
0.797 | -0.006 | -3 | 0.762 |
MAPKAPK3 |
0.797 | -0.007 | -3 | 0.686 |
CDKL5 |
0.797 | -0.027 | -3 | 0.718 |
AURC |
0.797 | 0.031 | -2 | 0.666 |
PKACG |
0.797 | 0.003 | -2 | 0.739 |
GRK7 |
0.797 | 0.081 | 1 | 0.698 |
ANKRD3 |
0.796 | -0.058 | 1 | 0.838 |
DNAPK |
0.796 | 0.133 | 1 | 0.804 |
CLK4 |
0.796 | 0.058 | -3 | 0.691 |
RSK3 |
0.796 | -0.027 | -3 | 0.694 |
PLK3 |
0.795 | 0.103 | 2 | 0.759 |
MLK3 |
0.795 | -0.015 | 2 | 0.758 |
CLK2 |
0.795 | 0.107 | -3 | 0.681 |
PRKX |
0.795 | 0.082 | -3 | 0.616 |
PKACB |
0.795 | 0.060 | -2 | 0.692 |
P70S6KB |
0.795 | -0.018 | -3 | 0.715 |
ACVR2A |
0.794 | 0.110 | -2 | 0.849 |
ACVR2B |
0.794 | 0.116 | -2 | 0.857 |
TLK2 |
0.794 | 0.060 | 1 | 0.829 |
DLK |
0.794 | -0.062 | 1 | 0.784 |
PKR |
0.793 | 0.022 | 1 | 0.852 |
PRKD3 |
0.793 | 0.006 | -3 | 0.665 |
CLK1 |
0.793 | 0.054 | -3 | 0.667 |
SRPK3 |
0.793 | 0.008 | -3 | 0.665 |
BMPR1A |
0.792 | 0.161 | 1 | 0.684 |
AMPKA2 |
0.792 | -0.055 | -3 | 0.733 |
WNK3 |
0.792 | -0.168 | 1 | 0.821 |
NUAK1 |
0.792 | -0.050 | -3 | 0.711 |
MNK2 |
0.791 | 0.005 | -2 | 0.775 |
IRE2 |
0.791 | -0.057 | 2 | 0.767 |
MLK2 |
0.791 | -0.113 | 2 | 0.826 |
MSK2 |
0.791 | 0.003 | -3 | 0.673 |
CAMK4 |
0.791 | -0.041 | -3 | 0.732 |
IRE1 |
0.791 | -0.107 | 1 | 0.812 |
RSK4 |
0.791 | 0.030 | -3 | 0.678 |
PKCB |
0.790 | -0.013 | 2 | 0.754 |
CDK8 |
0.790 | 0.006 | 1 | 0.667 |
MSK1 |
0.790 | 0.039 | -3 | 0.674 |
CDK1 |
0.790 | 0.053 | 1 | 0.621 |
MLK4 |
0.789 | -0.022 | 2 | 0.730 |
PAK1 |
0.789 | 0.001 | -2 | 0.760 |
MASTL |
0.788 | -0.194 | -2 | 0.764 |
CDK5 |
0.788 | 0.027 | 1 | 0.693 |
PKCA |
0.788 | -0.019 | 2 | 0.745 |
AURB |
0.787 | 0.013 | -2 | 0.668 |
NIM1 |
0.787 | -0.078 | 3 | 0.810 |
RIPK1 |
0.787 | -0.141 | 1 | 0.805 |
TLK1 |
0.787 | 0.030 | -2 | 0.860 |
DYRK2 |
0.786 | 0.010 | 1 | 0.718 |
QSK |
0.786 | -0.068 | 4 | 0.450 |
CHK1 |
0.786 | 0.013 | -3 | 0.747 |
GSK3A |
0.786 | -0.009 | 4 | 0.273 |
JNK2 |
0.786 | 0.063 | 1 | 0.615 |
YSK4 |
0.786 | -0.050 | 1 | 0.764 |
PKCG |
0.786 | -0.043 | 2 | 0.747 |
TTBK2 |
0.785 | -0.112 | 2 | 0.682 |
MNK1 |
0.785 | 0.001 | -2 | 0.784 |
MEK1 |
0.785 | -0.086 | 2 | 0.848 |
MELK |
0.785 | -0.067 | -3 | 0.708 |
PHKG1 |
0.785 | -0.089 | -3 | 0.736 |
CDK19 |
0.785 | 0.008 | 1 | 0.631 |
AURA |
0.784 | 0.029 | -2 | 0.648 |
SMG1 |
0.784 | -0.002 | 1 | 0.838 |
MYLK4 |
0.784 | -0.011 | -2 | 0.758 |
SIK |
0.784 | -0.067 | -3 | 0.681 |
PKG2 |
0.784 | -0.001 | -2 | 0.684 |
NEK2 |
0.784 | -0.051 | 2 | 0.806 |
JNK3 |
0.783 | 0.046 | 1 | 0.649 |
PKCZ |
0.783 | -0.055 | 2 | 0.778 |
PAK3 |
0.783 | -0.053 | -2 | 0.758 |
PKCH |
0.783 | -0.049 | 2 | 0.736 |
AKT2 |
0.783 | 0.002 | -3 | 0.620 |
CDK18 |
0.782 | 0.008 | 1 | 0.607 |
VRK2 |
0.782 | -0.168 | 1 | 0.853 |
BRAF |
0.782 | 0.012 | -4 | 0.806 |
GSK3B |
0.782 | -0.049 | 4 | 0.261 |
CDK7 |
0.782 | -0.027 | 1 | 0.677 |
HRI |
0.782 | -0.060 | -2 | 0.856 |
PLK2 |
0.781 | 0.140 | -3 | 0.836 |
PERK |
0.781 | -0.033 | -2 | 0.838 |
HIPK2 |
0.781 | 0.033 | 1 | 0.638 |
CHAK1 |
0.781 | -0.093 | 2 | 0.757 |
MARK2 |
0.781 | -0.088 | 4 | 0.408 |
QIK |
0.781 | -0.143 | -3 | 0.748 |
GRK2 |
0.780 | -0.021 | -2 | 0.701 |
MARK3 |
0.779 | -0.083 | 4 | 0.421 |
NEK5 |
0.779 | -0.018 | 1 | 0.828 |
P38A |
0.779 | 0.004 | 1 | 0.694 |
PIM2 |
0.779 | -0.010 | -3 | 0.668 |
CDK13 |
0.779 | -0.003 | 1 | 0.651 |
PAK6 |
0.779 | -0.009 | -2 | 0.684 |
SGK3 |
0.778 | -0.011 | -3 | 0.676 |
HIPK1 |
0.778 | 0.014 | 1 | 0.733 |
CK1E |
0.778 | -0.010 | -3 | 0.557 |
CAMK1G |
0.778 | -0.036 | -3 | 0.680 |
CDK3 |
0.778 | 0.065 | 1 | 0.568 |
PAK2 |
0.778 | -0.047 | -2 | 0.743 |
PKACA |
0.778 | 0.037 | -2 | 0.648 |
MEKK1 |
0.777 | -0.078 | 1 | 0.804 |
DCAMKL1 |
0.777 | -0.029 | -3 | 0.701 |
P38B |
0.777 | 0.025 | 1 | 0.619 |
PINK1 |
0.777 | -0.088 | 1 | 0.842 |
P38G |
0.777 | 0.029 | 1 | 0.543 |
ERK1 |
0.776 | 0.011 | 1 | 0.616 |
MEKK3 |
0.776 | -0.058 | 1 | 0.773 |
BRSK1 |
0.776 | -0.086 | -3 | 0.707 |
ZAK |
0.776 | -0.082 | 1 | 0.757 |
MEKK2 |
0.775 | -0.070 | 2 | 0.811 |
CDK2 |
0.775 | 0.004 | 1 | 0.691 |
CDK17 |
0.775 | 0.003 | 1 | 0.550 |
DYRK1A |
0.775 | -0.003 | 1 | 0.742 |
ERK2 |
0.775 | -0.010 | 1 | 0.660 |
PLK4 |
0.775 | -0.082 | 2 | 0.623 |
PASK |
0.775 | 0.012 | -3 | 0.792 |
SSTK |
0.774 | -0.059 | 4 | 0.433 |
CAMK1D |
0.773 | 0.009 | -3 | 0.611 |
CK2A2 |
0.773 | 0.099 | 1 | 0.643 |
CK1D |
0.773 | 0.001 | -3 | 0.506 |
BRSK2 |
0.772 | -0.135 | -3 | 0.717 |
MAPKAPK5 |
0.772 | -0.080 | -3 | 0.634 |
AKT1 |
0.772 | -0.003 | -3 | 0.632 |
TAO3 |
0.772 | -0.047 | 1 | 0.779 |
MEK5 |
0.772 | -0.201 | 2 | 0.827 |
PRP4 |
0.771 | -0.032 | -3 | 0.658 |
SMMLCK |
0.771 | -0.034 | -3 | 0.734 |
MARK1 |
0.771 | -0.109 | 4 | 0.433 |
IRAK4 |
0.771 | -0.120 | 1 | 0.813 |
P38D |
0.771 | 0.039 | 1 | 0.593 |
PKCT |
0.771 | -0.062 | 2 | 0.747 |
DYRK4 |
0.770 | 0.028 | 1 | 0.638 |
DCAMKL2 |
0.770 | -0.039 | -3 | 0.726 |
MST3 |
0.770 | -0.070 | 2 | 0.835 |
CDK12 |
0.770 | -0.010 | 1 | 0.624 |
CDK16 |
0.770 | 0.014 | 1 | 0.568 |
CK1G1 |
0.770 | -0.034 | -3 | 0.554 |
CDK14 |
0.769 | -0.010 | 1 | 0.650 |
WNK4 |
0.769 | -0.126 | -2 | 0.793 |
GAK |
0.769 | 0.008 | 1 | 0.813 |
CK1A2 |
0.769 | -0.009 | -3 | 0.506 |
GRK3 |
0.769 | -0.018 | -2 | 0.665 |
NEK8 |
0.768 | -0.095 | 2 | 0.812 |
MPSK1 |
0.768 | -0.039 | 1 | 0.796 |
HIPK3 |
0.767 | -0.025 | 1 | 0.725 |
DRAK1 |
0.767 | -0.115 | 1 | 0.683 |
DYRK3 |
0.767 | 0.002 | 1 | 0.746 |
CDK9 |
0.767 | -0.028 | 1 | 0.657 |
PHKG2 |
0.766 | -0.096 | -3 | 0.703 |
SNRK |
0.766 | -0.187 | 2 | 0.666 |
DAPK3 |
0.766 | -0.007 | -3 | 0.722 |
DYRK1B |
0.765 | -0.003 | 1 | 0.662 |
CAMKK1 |
0.765 | -0.058 | -2 | 0.716 |
MST2 |
0.765 | -0.024 | 1 | 0.792 |
TNIK |
0.764 | 0.003 | 3 | 0.885 |
GCK |
0.763 | -0.002 | 1 | 0.792 |
PKCI |
0.763 | -0.071 | 2 | 0.750 |
PKCE |
0.763 | -0.031 | 2 | 0.733 |
AKT3 |
0.762 | 0.002 | -3 | 0.563 |
NEK4 |
0.762 | -0.066 | 1 | 0.809 |
NEK11 |
0.762 | -0.142 | 1 | 0.774 |
P70S6K |
0.762 | -0.065 | -3 | 0.628 |
CAMK1A |
0.761 | -0.001 | -3 | 0.584 |
EEF2K |
0.761 | -0.021 | 3 | 0.847 |
CDK10 |
0.761 | -0.009 | 1 | 0.637 |
LKB1 |
0.761 | -0.078 | -3 | 0.748 |
TAK1 |
0.761 | -0.014 | 1 | 0.818 |
TAO2 |
0.760 | -0.107 | 2 | 0.854 |
PDHK3_TYR |
0.760 | 0.236 | 4 | 0.553 |
SGK1 |
0.760 | 0.010 | -3 | 0.548 |
CHK2 |
0.760 | -0.022 | -3 | 0.561 |
MRCKA |
0.760 | 0.001 | -3 | 0.671 |
JNK1 |
0.760 | 0.020 | 1 | 0.598 |
ROCK2 |
0.760 | 0.013 | -3 | 0.701 |
CK2A1 |
0.760 | 0.055 | 1 | 0.620 |
TTK |
0.759 | 0.046 | -2 | 0.856 |
BUB1 |
0.759 | 0.040 | -5 | 0.811 |
MINK |
0.759 | -0.048 | 1 | 0.799 |
MAK |
0.758 | 0.029 | -2 | 0.676 |
PAK5 |
0.758 | -0.041 | -2 | 0.633 |
HGK |
0.758 | -0.066 | 3 | 0.881 |
MRCKB |
0.758 | -0.002 | -3 | 0.654 |
IRAK1 |
0.758 | -0.200 | -1 | 0.751 |
NEK1 |
0.758 | -0.049 | 1 | 0.801 |
CAMKK2 |
0.757 | -0.117 | -2 | 0.710 |
PDK1 |
0.757 | -0.102 | 1 | 0.777 |
DAPK1 |
0.756 | -0.024 | -3 | 0.708 |
MST1 |
0.756 | -0.031 | 1 | 0.789 |
PKN1 |
0.756 | -0.062 | -3 | 0.638 |
TTBK1 |
0.755 | -0.141 | 2 | 0.597 |
PAK4 |
0.755 | -0.033 | -2 | 0.644 |
ERK7 |
0.754 | -0.038 | 2 | 0.518 |
KHS1 |
0.754 | -0.006 | 1 | 0.800 |
LOK |
0.753 | -0.081 | -2 | 0.730 |
MAP3K15 |
0.753 | -0.138 | 1 | 0.749 |
CDK6 |
0.753 | -0.013 | 1 | 0.635 |
PDHK4_TYR |
0.752 | 0.113 | 2 | 0.877 |
DMPK1 |
0.752 | 0.018 | -3 | 0.680 |
KHS2 |
0.752 | -0.001 | 1 | 0.810 |
SLK |
0.752 | -0.057 | -2 | 0.672 |
HPK1 |
0.751 | -0.058 | 1 | 0.785 |
VRK1 |
0.751 | -0.133 | 2 | 0.842 |
LRRK2 |
0.751 | -0.152 | 2 | 0.833 |
MEKK6 |
0.750 | -0.186 | 1 | 0.781 |
SBK |
0.750 | -0.000 | -3 | 0.507 |
CDK4 |
0.750 | -0.017 | 1 | 0.618 |
MAP2K6_TYR |
0.749 | 0.068 | -1 | 0.896 |
OSR1 |
0.749 | -0.023 | 2 | 0.805 |
MOK |
0.749 | -0.012 | 1 | 0.748 |
TESK1_TYR |
0.748 | -0.051 | 3 | 0.900 |
MAP2K4_TYR |
0.748 | -0.003 | -1 | 0.885 |
STK33 |
0.746 | -0.109 | 2 | 0.593 |
MEK2 |
0.745 | -0.173 | 2 | 0.819 |
BMPR2_TYR |
0.745 | 0.018 | -1 | 0.893 |
YSK1 |
0.745 | -0.121 | 2 | 0.810 |
PDHK1_TYR |
0.745 | 0.031 | -1 | 0.908 |
ROCK1 |
0.744 | -0.007 | -3 | 0.663 |
RIPK2 |
0.744 | -0.186 | 1 | 0.719 |
PBK |
0.744 | -0.057 | 1 | 0.756 |
PKG1 |
0.742 | -0.040 | -2 | 0.611 |
EPHA6 |
0.742 | 0.024 | -1 | 0.904 |
MAP2K7_TYR |
0.742 | -0.137 | 2 | 0.854 |
RET |
0.741 | -0.033 | 1 | 0.791 |
LIMK2_TYR |
0.741 | -0.071 | -3 | 0.796 |
PKMYT1_TYR |
0.740 | -0.133 | 3 | 0.864 |
BIKE |
0.740 | 0.009 | 1 | 0.705 |
PINK1_TYR |
0.739 | -0.126 | 1 | 0.801 |
CRIK |
0.739 | -0.015 | -3 | 0.632 |
EPHB4 |
0.739 | 0.027 | -1 | 0.888 |
ALPHAK3 |
0.739 | -0.017 | -1 | 0.802 |
NEK3 |
0.738 | -0.169 | 1 | 0.761 |
HASPIN |
0.738 | -0.048 | -1 | 0.688 |
MYO3B |
0.738 | -0.074 | 2 | 0.826 |
TYK2 |
0.737 | -0.050 | 1 | 0.792 |
MYO3A |
0.736 | -0.067 | 1 | 0.811 |
ROS1 |
0.735 | -0.061 | 3 | 0.800 |
CK1A |
0.735 | -0.027 | -3 | 0.428 |
CSF1R |
0.735 | -0.038 | 3 | 0.806 |
ABL2 |
0.735 | -0.015 | -1 | 0.828 |
INSRR |
0.735 | 0.044 | 3 | 0.770 |
JAK2 |
0.735 | -0.041 | 1 | 0.783 |
MST1R |
0.734 | -0.119 | 3 | 0.825 |
TXK |
0.733 | 0.027 | 1 | 0.737 |
FER |
0.733 | 0.029 | 1 | 0.794 |
YANK3 |
0.733 | -0.058 | 2 | 0.374 |
TYRO3 |
0.733 | -0.108 | 3 | 0.830 |
LIMK1_TYR |
0.732 | -0.202 | 2 | 0.851 |
EPHA4 |
0.732 | 0.043 | 2 | 0.755 |
JAK3 |
0.732 | -0.060 | 1 | 0.754 |
YES1 |
0.731 | -0.025 | -1 | 0.847 |
DDR1 |
0.731 | -0.109 | 4 | 0.476 |
ASK1 |
0.731 | -0.124 | 1 | 0.734 |
FGR |
0.730 | -0.071 | 1 | 0.779 |
LCK |
0.730 | -0.019 | -1 | 0.832 |
KIT |
0.728 | -0.040 | 3 | 0.807 |
TAO1 |
0.728 | -0.126 | 1 | 0.729 |
ABL1 |
0.728 | -0.057 | -1 | 0.817 |
EPHB1 |
0.728 | -0.006 | 1 | 0.762 |
HCK |
0.728 | -0.045 | -1 | 0.828 |
EPHB3 |
0.727 | 0.011 | -1 | 0.875 |
BLK |
0.727 | 0.007 | -1 | 0.840 |
EPHB2 |
0.727 | 0.022 | -1 | 0.869 |
FGFR2 |
0.727 | -0.031 | 3 | 0.805 |
AAK1 |
0.727 | 0.039 | 1 | 0.610 |
FLT3 |
0.727 | -0.065 | 3 | 0.819 |
KDR |
0.727 | -0.069 | 3 | 0.770 |
SRMS |
0.726 | 0.010 | 1 | 0.762 |
PDGFRB |
0.725 | -0.089 | 3 | 0.826 |
TNK2 |
0.724 | -0.077 | 3 | 0.781 |
JAK1 |
0.723 | -0.041 | 1 | 0.738 |
STLK3 |
0.723 | -0.127 | 1 | 0.731 |
FLT1 |
0.722 | -0.027 | -1 | 0.889 |
NEK10_TYR |
0.722 | -0.090 | 1 | 0.687 |
ITK |
0.721 | -0.073 | -1 | 0.805 |
TNK1 |
0.721 | -0.106 | 3 | 0.806 |
MET |
0.721 | -0.085 | 3 | 0.804 |
TNNI3K_TYR |
0.721 | -0.104 | 1 | 0.795 |
MERTK |
0.720 | -0.027 | 3 | 0.790 |
FYN |
0.720 | 0.019 | -1 | 0.811 |
TEK |
0.719 | -0.110 | 3 | 0.765 |
TEC |
0.719 | -0.055 | -1 | 0.743 |
FGFR1 |
0.719 | -0.110 | 3 | 0.788 |
BMX |
0.718 | -0.037 | -1 | 0.729 |
CK1G3 |
0.718 | -0.014 | -3 | 0.388 |
DDR2 |
0.718 | -0.003 | 3 | 0.750 |
EPHA7 |
0.718 | -0.021 | 2 | 0.753 |
FGFR3 |
0.718 | -0.033 | 3 | 0.779 |
NTRK1 |
0.717 | -0.025 | -1 | 0.862 |
EPHA3 |
0.717 | -0.044 | 2 | 0.728 |
AXL |
0.717 | -0.086 | 3 | 0.798 |
ALK |
0.717 | -0.083 | 3 | 0.738 |
EPHA5 |
0.716 | 0.029 | 2 | 0.740 |
PDGFRA |
0.716 | -0.155 | 3 | 0.824 |
WEE1_TYR |
0.716 | -0.085 | -1 | 0.755 |
ERBB2 |
0.716 | -0.087 | 1 | 0.717 |
PTK6 |
0.715 | -0.106 | -1 | 0.743 |
LTK |
0.714 | -0.080 | 3 | 0.751 |
BTK |
0.714 | -0.144 | -1 | 0.763 |
INSR |
0.714 | -0.062 | 3 | 0.751 |
LYN |
0.713 | -0.060 | 3 | 0.732 |
MATK |
0.713 | -0.046 | -1 | 0.768 |
FLT4 |
0.713 | -0.084 | 3 | 0.758 |
EGFR |
0.712 | 0.003 | 1 | 0.604 |
FRK |
0.712 | -0.088 | -1 | 0.843 |
NTRK2 |
0.712 | -0.099 | 3 | 0.770 |
PTK2 |
0.711 | 0.032 | -1 | 0.843 |
EPHA1 |
0.710 | -0.112 | 3 | 0.780 |
NTRK3 |
0.710 | -0.044 | -1 | 0.816 |
FGFR4 |
0.710 | 0.000 | -1 | 0.812 |
EPHA8 |
0.709 | -0.029 | -1 | 0.856 |
SYK |
0.709 | 0.038 | -1 | 0.821 |
SRC |
0.705 | -0.049 | -1 | 0.811 |
CSK |
0.705 | -0.053 | 2 | 0.757 |
IGF1R |
0.704 | -0.001 | 3 | 0.691 |
EPHA2 |
0.704 | 0.001 | -1 | 0.829 |
PTK2B |
0.703 | -0.075 | -1 | 0.777 |
YANK2 |
0.699 | -0.088 | 2 | 0.395 |
CK1G2 |
0.698 | -0.031 | -3 | 0.477 |
ERBB4 |
0.698 | -0.028 | 1 | 0.608 |
MUSK |
0.690 | -0.145 | 1 | 0.605 |
ZAP70 |
0.685 | -0.030 | -1 | 0.732 |
FES |
0.679 | -0.105 | -1 | 0.713 |