Motif 638 (n=205)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYK5 | None | S191 | ochoa | Uncharacterized protein | None |
| A0FGR8 | ESYT2 | S699 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A0JNW5 | BLTP3B | S752 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A6H8Y1 | BDP1 | S422 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| H3BU86 | STX16-NPEPL1 | S201 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| O00192 | ARVCF | S606 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00515 | LAD1 | S251 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00567 | NOP56 | S530 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14529 | CUX2 | S927 | ochoa | Homeobox protein cut-like 2 (Homeobox protein cux-2) | Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. {ECO:0000250|UniProtKB:P70298}. |
| O14654 | IRS4 | S944 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14662 | STX16 | S201 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14981 | BTAF1 | S261 | ochoa | TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) | Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. |
| O15061 | SYNM | S1132 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15417 | TNRC18 | S1563 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15504 | NUP42 | S106 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O43182 | ARHGAP6 | S711 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43290 | SART1 | S521 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O60303 | KATNIP | S678 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60779 | SLC19A2 | S244 | ochoa | Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1) | High-affinity transporter for the intake of thiamine (PubMed:10391222, PubMed:10542220, PubMed:21836059, PubMed:33008889, PubMed:35512554, PubMed:35724964). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964). {ECO:0000269|PubMed:10391222, ECO:0000269|PubMed:10542220, ECO:0000269|PubMed:21836059, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964}. |
| O75122 | CLASP2 | S1057 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O94913 | PCF11 | S325 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| P00441 | SOD1 | S60 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P05060 | CHGB | S144 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06733 | ENO1 | S27 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P09661 | SNRPA1 | S226 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P0DP23 | CALM1 | S102 | ochoa|psp | Calmodulin-1 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:23893133, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. {ECO:0000269|PubMed:31330532}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P0DP24 | CALM2 | S102 | ochoa | Calmodulin-2 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P0DP25 | CALM3 | S102 | ochoa | Calmodulin-3 | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}. |
| P10071 | GLI3 | S445 | ochoa | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10451 | SPP1 | S263 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S275 | ochoa | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11586 | MTHFD1 | S318 | ochoa | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| P12757 | SKIL | S514 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P12956 | XRCC6 | S314 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P14923 | JUP | S28 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P14923 | JUP | S99 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P16070 | CD44 | S697 | ochoa|psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P17036 | ZNF3 | S143 | ochoa | Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) | Involved in cell differentiation and/or proliferation. |
| P17706 | PTPN2 | S304 | ochoa | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}. |
| P23588 | EIF4B | S359 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P25054 | APC | S969 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27815 | PDE4A | S344 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P29536 | LMOD1 | S133 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P31327 | CPS1 | S137 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P35568 | IRS1 | S531 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35968 | KDR | S1227 | ochoa | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| P38398 | BRCA1 | S1239 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38398 | BRCA1 | S1642 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P39748 | FEN1 | S187 | psp | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P39880 | CUX1 | S974 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P46100 | ATRX | S112 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49368 | CCT3 | S243 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P50991 | CCT4 | S381 | ochoa|psp | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51532 | SMARCA4 | S1430 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51608 | MECP2 | S216 | ochoa|psp | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P54760 | EPHB4 | S907 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P61129 | ZC3H6 | S188 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
| P68104 | EEF1A1 | S21 | ochoa|psp | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P82094 | TMF1 | S542 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01831 | XPC | S351 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q03164 | KMT2A | S2729 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05639 | EEF1A2 | S21 | ochoa|psp | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q08AN1 | ZNF616 | S49 | ochoa | Zinc finger protein 616 | May be involved in transcriptional regulation. |
| Q09666 | AHNAK | S1123 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13017 | ARHGAP5 | S1115 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13177 | PAK2 | S152 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13507 | TRPC3 | S336 | psp | Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.; FUNCTION: [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. {ECO:0000269|PubMed:8646775}. |
| Q13526 | PIN1 | S65 | psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13625 | TP53BP2 | S92 | psp | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14005 | IL16 | S1077 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14596 | NBR1 | S622 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14680 | MELK | S498 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q15233 | NONO | S147 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15424 | SAFB | S79 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15596 | NCOA2 | S29 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15596 | NCOA2 | S771 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16625 | OCLN | S277 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q29RF7 | PDS5A | S1177 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q3B820 | FAM161A | S462 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
| Q52LD8 | RFTN2 | S430 | ochoa | Raftlin-2 (Raft-linking protein 2) | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}. |
| Q52LW3 | ARHGAP29 | S357 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5BKZ1 | ZNF326 | S56 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5HYI7 | MTX3 | S284 | ochoa | Metaxin-3 | Could function in transport of proteins into the mitochondrion. {ECO:0000250}. |
| Q5JTV8 | TOR1AIP1 | S79 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5T8P6 | RBM26 | S90 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5THJ4 | VPS13D | S1712 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VT06 | CEP350 | S2206 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VTE0 | EEF1A1P5 | S21 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5VWN6 | TASOR2 | S1721 | ochoa | Protein TASOR 2 | None |
| Q5VZ89 | DENND4C | S1104 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5VZL5 | ZMYM4 | S782 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q66K14 | TBC1D9B | S753 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68CZ2 | TNS3 | S388 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68EA5 | ZNF57 | S154 | ochoa | Zinc finger protein 57 (Zinc finger protein 424) | May be involved in transcriptional regulation. |
| Q6KC79 | NIPBL | S1196 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P4F7 | ARHGAP11A | S291 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PD62 | CTR9 | S932 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PL18 | ATAD2 | S214 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6PL18 | ATAD2 | S422 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZV73 | FGD6 | S62 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q6ZV73 | FGD6 | S663 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q71RC2 | LARP4 | S392 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7Z401 | DENND4A | S910 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z418 | KCNK18 | S252 | psp | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:12754259, PubMed:15562060, PubMed:20871611, PubMed:22355750, PubMed:26919430, PubMed:30573346). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611, ECO:0000269|PubMed:22355750, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:34702947}. |
| Q7Z460 | CLASP1 | S281 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q86UE4 | MTDH | S214 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q8IVF2 | AHNAK2 | S797 | ochoa | Protein AHNAK2 | None |
| Q8IX21 | SLF2 | S485 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IXS8 | HYCC2 | S321 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8N3C0 | ASCC3 | S298 | ochoa | Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q8N4C6 | NIN | S1783 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N697 | SLC15A4 | S291 | ochoa | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}. |
| Q8N9B5 | JMY | S713 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NAP3 | ZBTB38 | S128 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NAP3 | ZBTB38 | S1151 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NC51 | SERBP1 | S252 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NEC7 | GSTCD | S232 | ochoa | Glutathione S-transferase C-terminal domain-containing protein | None |
| Q8NEY1 | NAV1 | S206 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFZ5 | TNIP2 | S190 | ochoa | TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
| Q8NG08 | HELB | S711 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8NHV4 | NEDD1 | S586 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TC05 | MDM1 | S584 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TF76 | HASPIN | S288 | ochoa|psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WWM7 | ATXN2L | S306 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WXE9 | STON2 | S767 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q92615 | LARP4B | S488 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92628 | KIAA0232 | S164 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92667 | AKAP1 | S169 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92797 | SYMPK | S1222 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92922 | SMARCC1 | S760 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96A65 | EXOC4 | S254 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96KQ7 | EHMT2 | S242 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96NE9 | FRMD6 | S429 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96ST2 | IWS1 | S554 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96T58 | SPEN | S1897 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99590 | SCAF11 | S1030 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BRJ6 | C7orf50 | S59 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BSV6 | TSEN34 | S142 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BT81 | SOX7 | S139 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9BTC0 | DIDO1 | S352 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVG4 | PBDC1 | S181 | ochoa | Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) | None |
| Q9BVV6 | KIAA0586 | S1151 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BVW5 | TIPIN | S222 | ochoa | TIMELESS-interacting protein | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}. |
| Q9BW71 | HIRIP3 | S27 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BZV2 | SLC19A3 | S211 | ochoa | Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) | Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177). {ECO:0000269|PubMed:11731220, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964, ECO:0000269|PubMed:36456177}. |
| Q9GZY6 | LAT2 | S167 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H063 | MAF1 | S209 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9H3C7 | GGNBP2 | S470 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H7X7 | IFT22 | S137 | ochoa | Intraflagellar transport protein 22 homolog (Rab-like protein 5) | Small GTPase-like component of the intraflagellar transport (IFT) complex B. {ECO:0000250}. |
| Q9HA65 | TBC1D17 | S20 | ochoa | TBC1 domain family member 17 | Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Q9HAV4 | XPO5 | S826 | ochoa | Exportin-5 (Exp5) (Ran-binding protein 21) | Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.; FUNCTION: Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14631048, PubMed:14681208, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479). {ECO:0000269|PubMed:14631048, ECO:0000269|PubMed:14681208, ECO:0000269|PubMed:15613540, ECO:0000269|PubMed:19965479}.; FUNCTION: (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA. {ECO:0000269|PubMed:12509441}. |
| Q9HC77 | CPAP | S1109 | ochoa|psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQ92 | COPRS | S66 | ochoa | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}. |
| Q9NRH2 | SNRK | S275 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NUM4 | TMEM106B | S33 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NUQ6 | SPATS2L | S120 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NW68 | BSDC1 | S388 | ochoa | BSD domain-containing protein 1 | None |
| Q9NWF9 | RNF216 | S346 | ochoa | E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) | [Isoform 1]: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination (PubMed:34998453). Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9 (PubMed:15107846, PubMed:19893624). In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition (PubMed:25484083). Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (PubMed:24945773). Plays aso an essential role in spermatogenesis and male fertility (By similarity). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (By similarity). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (By similarity). {ECO:0000250|UniProtKB:P58283, ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624, ECO:0000269|PubMed:24945773, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:34998453}.; FUNCTION: [Isoform 3]: Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:11854271}. |
| Q9P2D6 | FAM135A | S454 | ochoa | Protein FAM135A | None |
| Q9P2R6 | RERE | S641 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UBW5 | BIN2 | S498 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGN4 | CD300A | S269 | ochoa | CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}. |
| Q9UHD2 | TBK1 | Y677 | psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UHR5 | SAP30BP | S104 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UIG0 | BAZ1B | S349 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJC3 | HOOK1 | S167 | ochoa | Protein Hook homolog 1 (h-hook1) (hHK1) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9UKJ3 | GPATCH8 | S637 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKJ3 | GPATCH8 | S1065 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKK3 | PARP4 | S1048 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKY7 | CDV3 | S107 | ochoa | Protein CDV3 homolog | None |
| Q9UPT8 | ZC3H4 | S908 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9Y2J8 | PADI2 | S82 | ochoa | Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) | Catalyzes the deimination of arginine residues of proteins. {ECO:0000269|PubMed:12392711, ECO:0000269|PubMed:25621824, ECO:0000269|PubMed:30044909}. |
| Q9Y2Z0 | SUGT1 | S279 | ochoa | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y508 | RNF114 | S165 | ochoa | E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313) | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Also acts as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. {ECO:0000269|PubMed:23645206, ECO:0000269|PubMed:25165885, ECO:0000269|PubMed:28625874, ECO:0000269|PubMed:28708287}. |
| Q9Y616 | IRAK3 | S325 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| Q9Y6J0 | CABIN1 | S1740 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6N9 | USH1C | S287 | ochoa | Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018}. |
| Q9Y6Y8 | SEC23IP | S895 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q9Y2B0 | CNPY2 | S65 | Sugiyama | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9UGY1 | NOL12 | S21 | Sugiyama | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| P84095 | RHOG | S44 | Sugiyama | Rho-related GTP-binding protein RhoG | Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601). {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:33513601}.; FUNCTION: (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:17074883}. |
| Q16719 | KYNU | S443 | Sugiyama | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| O75223 | GGCT | Y156 | Sugiyama | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
| Q99543 | DNAJC2 | S275 | Sugiyama | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| P25398 | RPS12 | S107 | Sugiyama | Small ribosomal subunit protein eS12 (40S ribosomal protein S12) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity). {ECO:0000250|UniProtKB:P80455, ECO:0000269|PubMed:34516797}. |
| O95835 | LATS1 | S876 | Sugiyama | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P54709 | ATP1B3 | S102 | Sugiyama | Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298) | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. |
| Q9NZV7 | ZIM2 | S155 | Sugiyama | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q14683 | SMC1A | Y186 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q9H1I8 | ASCC2 | S549 | Sugiyama | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| P49760 | CLK2 | S426 | Sugiyama | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| Q9Y617 | PSAT1 | S43 | Sugiyama | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q8WWH5 | TRUB1 | S268 | Sugiyama | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q01082 | SPTBN1 | S1670 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q13464 | ROCK1 | S418 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q9Y3T9 | NOC2L | S682 | Sugiyama | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| P29144 | TPP2 | S221 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| Q15382 | RHEB | S149 | Sugiyama | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q8NEZ2 | VPS37A | S324 | Sugiyama | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
| Q9Y5K5 | UCHL5 | S131 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}. |
| O95479 | H6PD | S106 | Sugiyama | GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] | Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520). {ECO:0000250|UniProtKB:Q8CFX1, ECO:0000269|PubMed:12858176, ECO:0000269|PubMed:18628520, ECO:0000269|PubMed:23132696}. |
| Q9NRM7 | LATS2 | S839 | Sugiyama | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9UQ07 | MOK | S317 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
| Q14524 | SCN5A | S1920 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q86UR5 | RIMS1 | S288 | SIGNOR | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.000001 | 5.848 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.000147 | 3.833 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000178 | 3.750 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000256 | 3.591 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000388 | 3.411 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.000415 | 3.382 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000610 | 3.214 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000658 | 3.182 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.000884 | 3.053 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.001598 | 2.796 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.001598 | 2.796 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.001598 | 2.796 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.001181 | 2.928 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.001331 | 2.876 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.001345 | 2.871 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 0.001898 | 2.722 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.002361 | 2.627 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.002229 | 2.652 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.002610 | 2.583 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.003368 | 2.473 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.003433 | 2.464 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.004542 | 2.343 |
| R-HSA-74160 | Gene expression (Transcription) | 0.004936 | 2.307 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.005878 | 2.231 |
| R-HSA-427975 | Proton/oligopeptide cotransporters | 0.005878 | 2.231 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005878 | 2.231 |
| R-HSA-75153 | Apoptotic execution phase | 0.007543 | 2.122 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.009017 | 2.045 |
| R-HSA-9959399 | SLC-mediated transport of oligopeptides | 0.009017 | 2.045 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.009017 | 2.045 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.009017 | 2.045 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.010811 | 1.966 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.010811 | 1.966 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.011055 | 1.956 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.013998 | 1.854 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.014824 | 1.829 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.014824 | 1.829 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.014824 | 1.829 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.015940 | 1.798 |
| R-HSA-196819 | Vitamin B1 (thiamin) metabolism | 0.017036 | 1.769 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.016619 | 1.779 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.017093 | 1.767 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.019535 | 1.709 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.027801 | 1.556 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.027801 | 1.556 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.027801 | 1.556 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.027801 | 1.556 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.027801 | 1.556 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.027801 | 1.556 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.027801 | 1.556 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.027801 | 1.556 |
| R-HSA-1299344 | TWIK-related spinal cord K+ channel (TRESK) | 0.027801 | 1.556 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.024439 | 1.612 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.027149 | 1.566 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.027149 | 1.566 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.029975 | 1.523 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.029975 | 1.523 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.021847 | 1.661 |
| R-HSA-5617833 | Cilium Assembly | 0.029922 | 1.524 |
| R-HSA-73942 | DNA Damage Reversal | 0.029975 | 1.523 |
| R-HSA-8876725 | Protein methylation | 0.029975 | 1.523 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.027959 | 1.553 |
| R-HSA-449147 | Signaling by Interleukins | 0.021728 | 1.663 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.031132 | 1.507 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.054833 | 1.261 |
| R-HSA-74713 | IRS activation | 0.093984 | 1.027 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.106673 | 0.972 |
| R-HSA-112412 | SOS-mediated signalling | 0.131521 | 0.881 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.035957 | 1.444 |
| R-HSA-3928664 | Ephrin signaling | 0.042356 | 1.373 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.049144 | 1.309 |
| R-HSA-164843 | 2-LTR circle formation | 0.167508 | 0.776 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.167508 | 0.776 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.059999 | 1.222 |
| R-HSA-4839744 | Signaling by APC mutants | 0.179171 | 0.747 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.179171 | 0.747 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.179171 | 0.747 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.179171 | 0.747 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.067647 | 1.170 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.190671 | 0.720 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.190671 | 0.720 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.071585 | 1.145 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.071585 | 1.145 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.202011 | 0.695 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.202011 | 0.695 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.202011 | 0.695 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.202011 | 0.695 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.202011 | 0.695 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.202011 | 0.695 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.213192 | 0.671 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.235089 | 0.629 |
| R-HSA-1221632 | Meiotic synapsis | 0.056079 | 1.251 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.137928 | 0.860 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.142727 | 0.845 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.080054 | 1.097 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.080054 | 1.097 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.287214 | 0.542 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.087986 | 1.056 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.297207 | 0.527 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.297207 | 0.527 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.297207 | 0.527 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.297207 | 0.527 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.107699 | 0.968 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.316775 | 0.499 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.316775 | 0.499 |
| R-HSA-380287 | Centrosome maturation | 0.113623 | 0.945 |
| R-HSA-72187 | mRNA 3'-end processing | 0.207654 | 0.683 |
| R-HSA-429947 | Deadenylation of mRNA | 0.345116 | 0.462 |
| R-HSA-72649 | Translation initiation complex formation | 0.217929 | 0.662 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.354300 | 0.451 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.228248 | 0.642 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.158220 | 0.801 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.248975 | 0.604 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.185764 | 0.731 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.389772 | 0.409 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.398333 | 0.400 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.406774 | 0.391 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.406774 | 0.391 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.406774 | 0.391 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.382376 | 0.418 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.382376 | 0.418 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.362319 | 0.441 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.363356 | 0.440 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.164984 | 0.783 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.224218 | 0.649 |
| R-HSA-9620244 | Long-term potentiation | 0.354300 | 0.451 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.167212 | 0.777 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.187277 | 0.728 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.155680 | 0.808 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.096647 | 1.015 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.175286 | 0.756 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.143685 | 0.843 |
| R-HSA-198203 | PI3K/AKT activation | 0.167508 | 0.776 |
| R-HSA-6798695 | Neutrophil degranulation | 0.140779 | 0.851 |
| R-HSA-156902 | Peptide chain elongation | 0.397242 | 0.401 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.154871 | 0.810 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.057504 | 1.240 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.167508 | 0.776 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.106673 | 0.972 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.256380 | 0.591 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.316775 | 0.499 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.326355 | 0.486 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.413462 | 0.384 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.114526 | 0.941 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.037110 | 1.431 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.306065 | 0.514 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.357267 | 0.447 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.398333 | 0.400 |
| R-HSA-194138 | Signaling by VEGF | 0.049521 | 1.305 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.093984 | 1.027 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.106673 | 0.972 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.143685 | 0.843 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.155680 | 0.808 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.190671 | 0.720 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.224218 | 0.649 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.114526 | 0.941 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.157328 | 0.803 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.125028 | 0.903 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.363356 | 0.440 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.326355 | 0.486 |
| R-HSA-5693538 | Homology Directed Repair | 0.285545 | 0.544 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.297207 | 0.527 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.415097 | 0.382 |
| R-HSA-391251 | Protein folding | 0.175286 | 0.756 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.041412 | 1.383 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.054833 | 1.261 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.068067 | 1.167 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.068067 | 1.167 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.106673 | 0.972 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.042356 | 1.373 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.167508 | 0.776 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.179171 | 0.747 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.063784 | 1.195 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.067647 | 1.170 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.190671 | 0.720 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.190671 | 0.720 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.190671 | 0.720 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.079678 | 1.099 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.083826 | 1.077 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.213192 | 0.671 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.213192 | 0.671 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.088039 | 1.055 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.235089 | 0.629 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.245809 | 0.609 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.277080 | 0.557 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.277080 | 0.557 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.277080 | 0.557 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.207654 | 0.683 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.212785 | 0.672 |
| R-HSA-1500620 | Meiosis | 0.144964 | 0.839 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.238600 | 0.622 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.254168 | 0.595 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.254168 | 0.595 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.389772 | 0.409 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.406774 | 0.391 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.311230 | 0.507 |
| R-HSA-68877 | Mitotic Prometaphase | 0.081429 | 1.089 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.096122 | 1.017 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.256380 | 0.591 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.387349 | 0.412 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.182228 | 0.739 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.256380 | 0.591 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.056079 | 1.251 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.114456 | 0.941 |
| R-HSA-74749 | Signal attenuation | 0.167508 | 0.776 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.363356 | 0.440 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.131521 | 0.881 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.131521 | 0.881 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.190671 | 0.720 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.224218 | 0.649 |
| R-HSA-9930044 | Nuclear RNA decay | 0.105482 | 0.977 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.119120 | 0.924 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.256380 | 0.591 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.326355 | 0.486 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.415097 | 0.382 |
| R-HSA-165159 | MTOR signalling | 0.157328 | 0.803 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.059999 | 1.222 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.255998 | 0.592 |
| R-HSA-2028269 | Signaling by Hippo | 0.039106 | 1.408 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.277080 | 0.557 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.269758 | 0.569 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.321535 | 0.493 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.373499 | 0.428 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.106673 | 0.972 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.190671 | 0.720 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.071585 | 1.145 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.213192 | 0.671 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.307060 | 0.513 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.307060 | 0.513 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.345116 | 0.462 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.141710 | 0.849 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.381091 | 0.419 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.381091 | 0.419 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.389772 | 0.409 |
| R-HSA-4839726 | Chromatin organization | 0.088414 | 1.053 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.045703 | 1.340 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.274955 | 0.561 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.381091 | 0.419 |
| R-HSA-9664873 | Pexophagy | 0.167508 | 0.776 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.354300 | 0.451 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.185764 | 0.731 |
| R-HSA-9842663 | Signaling by LTK | 0.202011 | 0.695 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.152429 | 0.817 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.300893 | 0.522 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.228248 | 0.642 |
| R-HSA-5578775 | Ion homeostasis | 0.228248 | 0.642 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.224218 | 0.649 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.372286 | 0.429 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.259364 | 0.586 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.398333 | 0.400 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.243785 | 0.613 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.248975 | 0.604 |
| R-HSA-397014 | Muscle contraction | 0.112104 | 0.950 |
| R-HSA-8953854 | Metabolism of RNA | 0.098995 | 1.004 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.106673 | 0.972 |
| R-HSA-428540 | Activation of RAC1 | 0.190671 | 0.720 |
| R-HSA-425561 | Sodium/Calcium exchangers | 0.190671 | 0.720 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.202011 | 0.695 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.202011 | 0.695 |
| R-HSA-180024 | DARPP-32 events | 0.088039 | 1.055 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.088039 | 1.055 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.224218 | 0.649 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.266803 | 0.574 |
| R-HSA-163615 | PKA activation | 0.277080 | 0.557 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.354300 | 0.451 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.363356 | 0.440 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.372286 | 0.429 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.053457 | 1.272 |
| R-HSA-73894 | DNA Repair | 0.170848 | 0.767 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.151545 | 0.819 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.285342 | 0.545 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.038018 | 1.420 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.147562 | 0.831 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.352200 | 0.453 |
| R-HSA-199991 | Membrane Trafficking | 0.237103 | 0.625 |
| R-HSA-422475 | Axon guidance | 0.404420 | 0.393 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.287214 | 0.542 |
| R-HSA-9675108 | Nervous system development | 0.345804 | 0.461 |
| R-HSA-162592 | Integration of provirus | 0.190671 | 0.720 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.128442 | 0.891 |
| R-HSA-5576891 | Cardiac conduction | 0.155341 | 0.809 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.277080 | 0.557 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.106673 | 0.972 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.106673 | 0.972 |
| R-HSA-164944 | Nef and signal transduction | 0.119184 | 0.924 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.049144 | 1.309 |
| R-HSA-210991 | Basigin interactions | 0.052676 | 1.278 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.105482 | 0.977 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.266803 | 0.574 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.297207 | 0.527 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.316775 | 0.499 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.398333 | 0.400 |
| R-HSA-68886 | M Phase | 0.211211 | 0.675 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.354300 | 0.451 |
| R-HSA-1474165 | Reproduction | 0.339122 | 0.470 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.389772 | 0.409 |
| R-HSA-449836 | Other interleukin signaling | 0.287214 | 0.542 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.122733 | 0.911 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.269758 | 0.569 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.214445 | 0.669 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.172193 | 0.764 |
| R-HSA-373755 | Semaphorin interactions | 0.264561 | 0.577 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.167508 | 0.776 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.213192 | 0.671 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.123760 | 0.907 |
| R-HSA-2160916 | Hyaluronan degradation | 0.354300 | 0.451 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.363356 | 0.440 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.070111 | 1.154 |
| R-HSA-9612973 | Autophagy | 0.101517 | 0.993 |
| R-HSA-9663891 | Selective autophagy | 0.397242 | 0.401 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.372286 | 0.429 |
| R-HSA-9659379 | Sensory processing of sound | 0.347119 | 0.460 |
| R-HSA-212436 | Generic Transcription Pathway | 0.055316 | 1.257 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.415097 | 0.382 |
| R-HSA-1632852 | Macroautophagy | 0.384892 | 0.415 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.041708 | 1.380 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.267713 | 0.572 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.235089 | 0.629 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.128442 | 0.891 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.307060 | 0.513 |
| R-HSA-3295583 | TRP channels | 0.363356 | 0.440 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.372286 | 0.429 |
| R-HSA-622312 | Inflammasomes | 0.381091 | 0.419 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.398333 | 0.400 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.290530 | 0.537 |
| R-HSA-3371556 | Cellular response to heat stress | 0.296994 | 0.527 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.316387 | 0.500 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.262775 | 0.580 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.213192 | 0.671 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.316775 | 0.499 |
| R-HSA-977347 | Serine metabolism | 0.316775 | 0.499 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.228248 | 0.642 |
| R-HSA-70635 | Urea cycle | 0.363356 | 0.440 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.398333 | 0.400 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.326674 | 0.486 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.415020 | 0.382 |
| R-HSA-1640170 | Cell Cycle | 0.333074 | 0.477 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.284054 | 0.547 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.213192 | 0.671 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.316775 | 0.499 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.398333 | 0.400 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.343817 | 0.464 |
| R-HSA-216083 | Integrin cell surface interactions | 0.122733 | 0.911 |
| R-HSA-168249 | Innate Immune System | 0.351661 | 0.454 |
| R-HSA-2586552 | Signaling by Leptin | 0.167508 | 0.776 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.316775 | 0.499 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.326355 | 0.486 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.398333 | 0.400 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.151510 | 0.820 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.101902 | 0.992 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.052676 | 1.278 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.143685 | 0.843 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.213192 | 0.671 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.316775 | 0.499 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.363356 | 0.440 |
| R-HSA-109581 | Apoptosis | 0.112750 | 0.948 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.287214 | 0.542 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.307060 | 0.513 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.345116 | 0.462 |
| R-HSA-69242 | S Phase | 0.415020 | 0.382 |
| R-HSA-162906 | HIV Infection | 0.270380 | 0.568 |
| R-HSA-162587 | HIV Life Cycle | 0.234757 | 0.629 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.056295 | 1.250 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.297207 | 0.527 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.372286 | 0.429 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.227160 | 0.644 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.071585 | 1.145 |
| R-HSA-373753 | Nephrin family interactions | 0.297207 | 0.527 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.287214 | 0.542 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.326355 | 0.486 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.326355 | 0.486 |
| R-HSA-5357801 | Programmed Cell Death | 0.213341 | 0.671 |
| R-HSA-69190 | DNA strand elongation | 0.415097 | 0.382 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.381948 | 0.418 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.236537 | 0.626 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.187277 | 0.728 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.232826 | 0.633 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.357267 | 0.447 |
| R-HSA-264876 | Insulin processing | 0.372286 | 0.429 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.281737 | 0.550 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.236537 | 0.626 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.256380 | 0.591 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.213978 | 0.670 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.266803 | 0.574 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.335802 | 0.474 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.382376 | 0.418 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.381091 | 0.419 |
| R-HSA-6806834 | Signaling by MET | 0.352200 | 0.453 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.335802 | 0.474 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.094840 | 1.023 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.293228 | 0.533 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.416702 | 0.380 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.422482 | 0.374 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.423304 | 0.373 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.423304 | 0.373 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.423304 | 0.373 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.423304 | 0.373 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.423304 | 0.373 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.423304 | 0.373 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.423304 | 0.373 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.423304 | 0.373 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.423304 | 0.373 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.423304 | 0.373 |
| R-HSA-68882 | Mitotic Anaphase | 0.426112 | 0.370 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.429241 | 0.367 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.431263 | 0.365 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.431396 | 0.365 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.431396 | 0.365 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.431396 | 0.365 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.431396 | 0.365 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.431396 | 0.365 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.431396 | 0.365 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.431396 | 0.365 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.431396 | 0.365 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.437308 | 0.359 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.437308 | 0.359 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.439375 | 0.357 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.439375 | 0.357 |
| R-HSA-203615 | eNOS activation | 0.439375 | 0.357 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.439375 | 0.357 |
| R-HSA-5205647 | Mitophagy | 0.439375 | 0.357 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.439375 | 0.357 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.439375 | 0.357 |
| R-HSA-5673000 | RAF activation | 0.439375 | 0.357 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.439375 | 0.357 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.446451 | 0.350 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.447243 | 0.349 |
| R-HSA-169911 | Regulation of Apoptosis | 0.447243 | 0.349 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.447243 | 0.349 |
| R-HSA-9610379 | HCMV Late Events | 0.448335 | 0.348 |
| R-HSA-72766 | Translation | 0.449472 | 0.347 |
| R-HSA-157579 | Telomere Maintenance | 0.450244 | 0.347 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.450244 | 0.347 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.450244 | 0.347 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.454933 | 0.342 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.455001 | 0.342 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.455001 | 0.342 |
| R-HSA-111997 | CaM pathway | 0.455001 | 0.342 |
| R-HSA-111933 | Calmodulin induced events | 0.455001 | 0.342 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.455001 | 0.342 |
| R-HSA-3371511 | HSF1 activation | 0.455001 | 0.342 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.455001 | 0.342 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.455001 | 0.342 |
| R-HSA-877300 | Interferon gamma signaling | 0.455638 | 0.341 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.462650 | 0.335 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.462650 | 0.335 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.462650 | 0.335 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.464243 | 0.333 |
| R-HSA-70171 | Glycolysis | 0.464243 | 0.333 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.468863 | 0.329 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.469459 | 0.328 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.470193 | 0.328 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.470193 | 0.328 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.470193 | 0.328 |
| R-HSA-8875878 | MET promotes cell motility | 0.470193 | 0.328 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.473459 | 0.325 |
| R-HSA-9648002 | RAS processing | 0.477630 | 0.321 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.477630 | 0.321 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.477630 | 0.321 |
| R-HSA-201556 | Signaling by ALK | 0.477630 | 0.321 |
| R-HSA-111885 | Opioid Signalling | 0.482580 | 0.316 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.482580 | 0.316 |
| R-HSA-168256 | Immune System | 0.483441 | 0.316 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.484963 | 0.314 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.484963 | 0.314 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.484963 | 0.314 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.484963 | 0.314 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.484963 | 0.314 |
| R-HSA-8982491 | Glycogen metabolism | 0.484963 | 0.314 |
| R-HSA-71240 | Tryptophan catabolism | 0.484963 | 0.314 |
| R-HSA-202433 | Generation of second messenger molecules | 0.484963 | 0.314 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.491603 | 0.308 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.492193 | 0.308 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.492193 | 0.308 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.492193 | 0.308 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.492193 | 0.308 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.492193 | 0.308 |
| R-HSA-418346 | Platelet homeostasis | 0.496077 | 0.304 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.498556 | 0.302 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.499323 | 0.302 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.499323 | 0.302 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.499323 | 0.302 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.499323 | 0.302 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.499323 | 0.302 |
| R-HSA-211000 | Gene Silencing by RNA | 0.500526 | 0.301 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.504210 | 0.297 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.504951 | 0.297 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.504951 | 0.297 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.504951 | 0.297 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.504951 | 0.297 |
| R-HSA-913531 | Interferon Signaling | 0.505674 | 0.296 |
| R-HSA-111996 | Ca-dependent events | 0.506353 | 0.296 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.506353 | 0.296 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.509349 | 0.293 |
| R-HSA-8854214 | TBC/RABGAPs | 0.513284 | 0.290 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.513284 | 0.290 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.513284 | 0.290 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.513723 | 0.289 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.513723 | 0.289 |
| R-HSA-373752 | Netrin-1 signaling | 0.520119 | 0.284 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.520119 | 0.284 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.522392 | 0.282 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.526688 | 0.278 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.526858 | 0.278 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.526858 | 0.278 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.530958 | 0.275 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.533503 | 0.273 |
| R-HSA-9675135 | Diseases of DNA repair | 0.533503 | 0.273 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.533503 | 0.273 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.533503 | 0.273 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.533503 | 0.273 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.533503 | 0.273 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.533503 | 0.273 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.533503 | 0.273 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.533503 | 0.273 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.533503 | 0.273 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.533503 | 0.273 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.535202 | 0.271 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.539420 | 0.268 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.540055 | 0.268 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.543060 | 0.265 |
| R-HSA-5688426 | Deubiquitination | 0.543579 | 0.265 |
| R-HSA-5620924 | Intraflagellar transport | 0.546515 | 0.262 |
| R-HSA-70263 | Gluconeogenesis | 0.546515 | 0.262 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.546515 | 0.262 |
| R-HSA-425410 | Metal ion SLC transporters | 0.546515 | 0.262 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.547775 | 0.261 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.547775 | 0.261 |
| R-HSA-373760 | L1CAM interactions | 0.547775 | 0.261 |
| R-HSA-70326 | Glucose metabolism | 0.551913 | 0.258 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.551913 | 0.258 |
| R-HSA-9766229 | Degradation of CDH1 | 0.552885 | 0.257 |
| R-HSA-69275 | G2/M Transition | 0.553005 | 0.257 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.556025 | 0.255 |
| R-HSA-109704 | PI3K Cascade | 0.559166 | 0.252 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.559563 | 0.252 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.559563 | 0.252 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.560110 | 0.252 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.560110 | 0.252 |
| R-HSA-983712 | Ion channel transport | 0.562821 | 0.250 |
| R-HSA-912446 | Meiotic recombination | 0.565359 | 0.248 |
| R-HSA-2514856 | The phototransduction cascade | 0.565359 | 0.248 |
| R-HSA-73886 | Chromosome Maintenance | 0.568199 | 0.245 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.571466 | 0.243 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.571466 | 0.243 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.571466 | 0.243 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.572204 | 0.242 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.572204 | 0.242 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.576181 | 0.239 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.577487 | 0.238 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.577487 | 0.238 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.579550 | 0.237 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.579979 | 0.237 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.580132 | 0.236 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.583424 | 0.234 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.595049 | 0.225 |
| R-HSA-75893 | TNF signaling | 0.595049 | 0.225 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.595049 | 0.225 |
| R-HSA-114608 | Platelet degranulation | 0.595664 | 0.225 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.596213 | 0.225 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.597677 | 0.224 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.600740 | 0.221 |
| R-HSA-112399 | IRS-mediated signalling | 0.600740 | 0.221 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.600740 | 0.221 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.600740 | 0.221 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.606352 | 0.217 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.606864 | 0.217 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.606864 | 0.217 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.607030 | 0.217 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.611885 | 0.213 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.611885 | 0.213 |
| R-HSA-191859 | snRNP Assembly | 0.611885 | 0.213 |
| R-HSA-180786 | Extension of Telomeres | 0.611885 | 0.213 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.611885 | 0.213 |
| R-HSA-156590 | Glutathione conjugation | 0.617340 | 0.209 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.617340 | 0.209 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.617340 | 0.209 |
| R-HSA-9909396 | Circadian clock | 0.618153 | 0.209 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.618153 | 0.209 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.621807 | 0.206 |
| R-HSA-112043 | PLC beta mediated events | 0.622719 | 0.206 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.622719 | 0.206 |
| R-HSA-450294 | MAP kinase activation | 0.622719 | 0.206 |
| R-HSA-211976 | Endogenous sterols | 0.622719 | 0.206 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.628023 | 0.202 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.628023 | 0.202 |
| R-HSA-9707616 | Heme signaling | 0.628023 | 0.202 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.628023 | 0.202 |
| R-HSA-186797 | Signaling by PDGF | 0.628023 | 0.202 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.631513 | 0.200 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.633253 | 0.198 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.633253 | 0.198 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.636153 | 0.196 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.638409 | 0.195 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.638409 | 0.195 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.643493 | 0.191 |
| R-HSA-6807070 | PTEN Regulation | 0.646632 | 0.189 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.648506 | 0.188 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.650011 | 0.187 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.653449 | 0.185 |
| R-HSA-112040 | G-protein mediated events | 0.653449 | 0.185 |
| R-HSA-196807 | Nicotinate metabolism | 0.653449 | 0.185 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.653449 | 0.185 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.653449 | 0.185 |
| R-HSA-195721 | Signaling by WNT | 0.657299 | 0.182 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.658323 | 0.182 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.660232 | 0.180 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.660232 | 0.180 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.667867 | 0.175 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.667867 | 0.175 |
| R-HSA-448424 | Interleukin-17 signaling | 0.667867 | 0.175 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.667867 | 0.175 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.667867 | 0.175 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.672538 | 0.172 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.672538 | 0.172 |
| R-HSA-8978934 | Metabolism of cofactors | 0.672538 | 0.172 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.676640 | 0.170 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.677145 | 0.169 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.680025 | 0.167 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.680562 | 0.167 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.681686 | 0.166 |
| R-HSA-4086398 | Ca2+ pathway | 0.681686 | 0.166 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.686165 | 0.164 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.686165 | 0.164 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.689300 | 0.162 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.690580 | 0.161 |
| R-HSA-8852135 | Protein ubiquitination | 0.690580 | 0.161 |
| R-HSA-72312 | rRNA processing | 0.690946 | 0.161 |
| R-HSA-5689603 | UCH proteinases | 0.694934 | 0.158 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.694934 | 0.158 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.699226 | 0.155 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.701551 | 0.154 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.703459 | 0.153 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.703459 | 0.153 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.703568 | 0.153 |
| R-HSA-8939211 | ESR-mediated signaling | 0.703568 | 0.153 |
| R-HSA-9679506 | SARS-CoV Infections | 0.705608 | 0.151 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.707632 | 0.150 |
| R-HSA-9711097 | Cellular response to starvation | 0.710475 | 0.148 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.711747 | 0.148 |
| R-HSA-9833482 | PKR-mediated signaling | 0.711747 | 0.148 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.716300 | 0.145 |
| R-HSA-162582 | Signal Transduction | 0.718384 | 0.144 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.719804 | 0.143 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.723748 | 0.140 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.727637 | 0.138 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.727637 | 0.138 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.731472 | 0.136 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.731472 | 0.136 |
| R-HSA-9609646 | HCMV Infection | 0.734548 | 0.134 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.738980 | 0.131 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.742655 | 0.129 |
| R-HSA-72306 | tRNA processing | 0.746607 | 0.127 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.749220 | 0.125 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.752316 | 0.124 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.753375 | 0.123 |
| R-HSA-73884 | Base Excision Repair | 0.753375 | 0.123 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.754378 | 0.122 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.754378 | 0.122 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.756848 | 0.121 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.760273 | 0.119 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.760273 | 0.119 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.761761 | 0.118 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.763650 | 0.117 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.763650 | 0.117 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.765446 | 0.116 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.766980 | 0.115 |
| R-HSA-168255 | Influenza Infection | 0.769306 | 0.114 |
| R-HSA-2559583 | Cellular Senescence | 0.771716 | 0.113 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.776690 | 0.110 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.776690 | 0.110 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.779837 | 0.108 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.779837 | 0.108 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.779837 | 0.108 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.779837 | 0.108 |
| R-HSA-1296071 | Potassium Channels | 0.779837 | 0.108 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.785998 | 0.105 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.785998 | 0.105 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.785998 | 0.105 |
| R-HSA-3214847 | HATs acetylate histones | 0.789014 | 0.103 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.789014 | 0.103 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.791988 | 0.101 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.794919 | 0.100 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.794919 | 0.100 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.797810 | 0.098 |
| R-HSA-2262752 | Cellular responses to stress | 0.799513 | 0.097 |
| R-HSA-192823 | Viral mRNA Translation | 0.800660 | 0.097 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.803224 | 0.095 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.803471 | 0.095 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.803471 | 0.095 |
| R-HSA-9609690 | HCMV Early Events | 0.807398 | 0.093 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.807398 | 0.093 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.808973 | 0.092 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.812323 | 0.090 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.814322 | 0.089 |
| R-HSA-69239 | Synthesis of DNA | 0.814322 | 0.089 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.816941 | 0.088 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.819450 | 0.086 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.819522 | 0.086 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.822068 | 0.085 |
| R-HSA-202403 | TCR signaling | 0.822068 | 0.085 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.824044 | 0.084 |
| R-HSA-72172 | mRNA Splicing | 0.825220 | 0.083 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.827052 | 0.082 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.827052 | 0.082 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.827052 | 0.082 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.832974 | 0.079 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.836607 | 0.077 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.838912 | 0.076 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.842500 | 0.074 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.843426 | 0.074 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.847814 | 0.072 |
| R-HSA-68875 | Mitotic Prophase | 0.849962 | 0.071 |
| R-HSA-418990 | Adherens junctions interactions | 0.850019 | 0.071 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.852080 | 0.070 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.852080 | 0.070 |
| R-HSA-1500931 | Cell-Cell communication | 0.854154 | 0.068 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.856227 | 0.067 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.858256 | 0.066 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.862231 | 0.064 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.862231 | 0.064 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.862231 | 0.064 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.864176 | 0.063 |
| R-HSA-69481 | G2/M Checkpoints | 0.866094 | 0.062 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.867218 | 0.062 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.867985 | 0.061 |
| R-HSA-1474244 | Extracellular matrix organization | 0.873702 | 0.059 |
| R-HSA-9843745 | Adipogenesis | 0.875287 | 0.058 |
| R-HSA-109582 | Hemostasis | 0.884137 | 0.053 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.885492 | 0.053 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.888706 | 0.051 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.890279 | 0.050 |
| R-HSA-9824446 | Viral Infection Pathways | 0.890656 | 0.050 |
| R-HSA-421270 | Cell-cell junction organization | 0.896319 | 0.048 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.897818 | 0.047 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.902052 | 0.045 |
| R-HSA-2187338 | Visual phototransduction | 0.903476 | 0.044 |
| R-HSA-166520 | Signaling by NTRKs | 0.904841 | 0.043 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.905192 | 0.043 |
| R-HSA-9758941 | Gastrulation | 0.906187 | 0.043 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.907852 | 0.042 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.909584 | 0.041 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.910112 | 0.041 |
| R-HSA-69306 | DNA Replication | 0.911383 | 0.040 |
| R-HSA-73887 | Death Receptor Signaling | 0.912637 | 0.040 |
| R-HSA-1989781 | PPARA activates gene expression | 0.913873 | 0.039 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.916293 | 0.038 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.917478 | 0.037 |
| R-HSA-446728 | Cell junction organization | 0.923942 | 0.034 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.924242 | 0.034 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.926544 | 0.033 |
| R-HSA-9658195 | Leishmania infection | 0.926544 | 0.033 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.927392 | 0.033 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.927415 | 0.033 |
| R-HSA-5619102 | SLC transporter disorders | 0.927415 | 0.033 |
| R-HSA-418555 | G alpha (s) signalling events | 0.932411 | 0.030 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.933368 | 0.030 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.934312 | 0.030 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.934312 | 0.030 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.936160 | 0.029 |
| R-HSA-382551 | Transport of small molecules | 0.947151 | 0.024 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.950627 | 0.022 |
| R-HSA-392499 | Metabolism of proteins | 0.952012 | 0.021 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.955204 | 0.020 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.955326 | 0.020 |
| R-HSA-5663205 | Infectious disease | 0.955636 | 0.020 |
| R-HSA-428157 | Sphingolipid metabolism | 0.955960 | 0.020 |
| R-HSA-1266738 | Developmental Biology | 0.957736 | 0.019 |
| R-HSA-6805567 | Keratinization | 0.959580 | 0.018 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.962904 | 0.016 |
| R-HSA-8951664 | Neddylation | 0.967385 | 0.014 |
| R-HSA-597592 | Post-translational protein modification | 0.968026 | 0.014 |
| R-HSA-112316 | Neuronal System | 0.969668 | 0.013 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.974796 | 0.011 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.977526 | 0.010 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.978608 | 0.009 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.980646 | 0.008 |
| R-HSA-416476 | G alpha (q) signalling events | 0.982388 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.984097 | 0.007 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.985595 | 0.006 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.986806 | 0.006 |
| R-HSA-1643685 | Disease | 0.989285 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 0.992567 | 0.003 |
| R-HSA-1280218 | Adaptive Immune System | 0.993916 | 0.003 |
| R-HSA-211859 | Biological oxidations | 0.996343 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.996415 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.998609 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.886 | 0.165 | 2 | 0.874 |
CLK3 |
0.876 | 0.243 | 1 | 0.941 |
NLK |
0.875 | 0.302 | 1 | 0.929 |
DSTYK |
0.872 | 0.155 | 2 | 0.894 |
KIS |
0.871 | 0.252 | 1 | 0.865 |
ERK5 |
0.869 | 0.217 | 1 | 0.910 |
NEK6 |
0.869 | 0.173 | -2 | 0.928 |
SRPK1 |
0.866 | 0.162 | -3 | 0.644 |
MOS |
0.866 | 0.042 | 1 | 0.874 |
NEK7 |
0.865 | 0.153 | -3 | 0.794 |
GCN2 |
0.865 | -0.066 | 2 | 0.811 |
PIM3 |
0.863 | 0.017 | -3 | 0.705 |
PRPK |
0.863 | -0.119 | -1 | 0.875 |
CDKL1 |
0.863 | 0.075 | -3 | 0.694 |
MTOR |
0.863 | -0.017 | 1 | 0.823 |
ULK2 |
0.863 | 0.010 | 2 | 0.790 |
IKKB |
0.863 | -0.066 | -2 | 0.842 |
CDC7 |
0.862 | -0.049 | 1 | 0.825 |
RAF1 |
0.861 | -0.049 | 1 | 0.822 |
CDKL5 |
0.860 | 0.093 | -3 | 0.689 |
MLK1 |
0.860 | 0.031 | 2 | 0.836 |
CDK5 |
0.860 | 0.300 | 1 | 0.867 |
CDK1 |
0.859 | 0.301 | 1 | 0.805 |
BMPR2 |
0.859 | -0.063 | -2 | 0.933 |
ATR |
0.858 | 0.030 | 1 | 0.865 |
SRPK2 |
0.858 | 0.133 | -3 | 0.575 |
TGFBR2 |
0.857 | 0.021 | -2 | 0.854 |
NDR2 |
0.857 | -0.032 | -3 | 0.699 |
MST4 |
0.857 | 0.055 | 2 | 0.876 |
CDK8 |
0.856 | 0.215 | 1 | 0.840 |
RIPK3 |
0.856 | -0.002 | 3 | 0.785 |
NUAK2 |
0.855 | 0.008 | -3 | 0.717 |
SRPK3 |
0.855 | 0.130 | -3 | 0.619 |
HIPK4 |
0.854 | 0.112 | 1 | 0.913 |
NEK9 |
0.854 | 0.061 | 2 | 0.854 |
TBK1 |
0.853 | -0.154 | 1 | 0.706 |
PKN3 |
0.853 | -0.028 | -3 | 0.707 |
PDHK4 |
0.853 | -0.285 | 1 | 0.850 |
CDK18 |
0.853 | 0.276 | 1 | 0.791 |
CAMK2G |
0.853 | -0.088 | 2 | 0.799 |
MLK3 |
0.852 | 0.078 | 2 | 0.770 |
CAMK1B |
0.852 | -0.093 | -3 | 0.736 |
IKKA |
0.852 | -0.029 | -2 | 0.847 |
CDK19 |
0.852 | 0.216 | 1 | 0.808 |
NDR1 |
0.852 | -0.045 | -3 | 0.702 |
CHAK2 |
0.851 | -0.009 | -1 | 0.860 |
NIK |
0.851 | -0.061 | -3 | 0.752 |
WNK1 |
0.851 | -0.021 | -2 | 0.873 |
CDK13 |
0.851 | 0.243 | 1 | 0.822 |
CDK3 |
0.851 | 0.311 | 1 | 0.758 |
IKKE |
0.851 | -0.144 | 1 | 0.701 |
ICK |
0.851 | 0.082 | -3 | 0.721 |
PDHK1 |
0.851 | -0.184 | 1 | 0.835 |
CDK2 |
0.851 | 0.246 | 1 | 0.856 |
PIM1 |
0.851 | 0.033 | -3 | 0.659 |
JNK2 |
0.850 | 0.294 | 1 | 0.792 |
PKCD |
0.850 | 0.032 | 2 | 0.809 |
IRE1 |
0.850 | 0.027 | 1 | 0.821 |
JNK3 |
0.850 | 0.273 | 1 | 0.823 |
GRK1 |
0.850 | 0.027 | -2 | 0.846 |
RSK2 |
0.850 | -0.002 | -3 | 0.656 |
ULK1 |
0.849 | -0.083 | -3 | 0.757 |
ERK1 |
0.849 | 0.260 | 1 | 0.804 |
GRK5 |
0.849 | -0.143 | -3 | 0.724 |
HUNK |
0.849 | -0.084 | 2 | 0.814 |
PRKD1 |
0.849 | -0.031 | -3 | 0.702 |
DYRK2 |
0.849 | 0.207 | 1 | 0.862 |
SKMLCK |
0.848 | -0.042 | -2 | 0.834 |
CDK7 |
0.848 | 0.197 | 1 | 0.849 |
PKN2 |
0.848 | -0.016 | -3 | 0.713 |
P90RSK |
0.847 | -0.020 | -3 | 0.668 |
P38G |
0.847 | 0.271 | 1 | 0.735 |
ANKRD3 |
0.847 | -0.022 | 1 | 0.854 |
PKR |
0.847 | 0.089 | 1 | 0.863 |
CDK17 |
0.847 | 0.261 | 1 | 0.741 |
P38A |
0.846 | 0.246 | 1 | 0.874 |
CAMLCK |
0.846 | -0.072 | -2 | 0.834 |
P38B |
0.846 | 0.272 | 1 | 0.813 |
MLK2 |
0.846 | -0.063 | 2 | 0.836 |
BCKDK |
0.846 | -0.136 | -1 | 0.836 |
CDK16 |
0.846 | 0.306 | 1 | 0.755 |
BMPR1B |
0.846 | 0.082 | 1 | 0.766 |
MARK4 |
0.845 | -0.084 | 4 | 0.829 |
IRE2 |
0.845 | 0.035 | 2 | 0.768 |
FAM20C |
0.845 | 0.040 | 2 | 0.582 |
PRKD2 |
0.845 | -0.024 | -3 | 0.650 |
DAPK2 |
0.845 | -0.079 | -3 | 0.747 |
ATM |
0.845 | 0.021 | 1 | 0.800 |
PRP4 |
0.844 | 0.207 | -3 | 0.715 |
ERK2 |
0.844 | 0.237 | 1 | 0.833 |
GRK6 |
0.844 | -0.060 | 1 | 0.811 |
LATS2 |
0.844 | -0.048 | -5 | 0.795 |
MLK4 |
0.844 | 0.023 | 2 | 0.743 |
CDK12 |
0.842 | 0.231 | 1 | 0.798 |
WNK3 |
0.842 | -0.194 | 1 | 0.820 |
DLK |
0.842 | -0.165 | 1 | 0.822 |
AMPKA1 |
0.842 | -0.089 | -3 | 0.722 |
P38D |
0.842 | 0.293 | 1 | 0.764 |
CLK4 |
0.841 | 0.088 | -3 | 0.652 |
RSK3 |
0.841 | -0.047 | -3 | 0.652 |
NIM1 |
0.841 | -0.074 | 3 | 0.797 |
CDK14 |
0.841 | 0.270 | 1 | 0.819 |
MASTL |
0.841 | -0.260 | -2 | 0.867 |
CLK1 |
0.841 | 0.119 | -3 | 0.629 |
HIPK1 |
0.840 | 0.205 | 1 | 0.873 |
PLK1 |
0.840 | 0.001 | -2 | 0.888 |
P70S6KB |
0.840 | -0.053 | -3 | 0.676 |
ALK4 |
0.840 | -0.002 | -2 | 0.884 |
PKCB |
0.840 | 0.015 | 2 | 0.770 |
GRK4 |
0.839 | -0.131 | -2 | 0.892 |
CDK9 |
0.839 | 0.200 | 1 | 0.826 |
HIPK2 |
0.839 | 0.216 | 1 | 0.795 |
MAPKAPK3 |
0.839 | -0.096 | -3 | 0.658 |
PINK1 |
0.839 | 0.105 | 1 | 0.910 |
CLK2 |
0.838 | 0.155 | -3 | 0.632 |
RIPK1 |
0.838 | -0.174 | 1 | 0.810 |
NEK2 |
0.838 | 0.024 | 2 | 0.831 |
TGFBR1 |
0.838 | 0.015 | -2 | 0.861 |
GRK7 |
0.838 | 0.039 | 1 | 0.760 |
PKCA |
0.838 | 0.021 | 2 | 0.760 |
PKCG |
0.837 | -0.007 | 2 | 0.761 |
CAMK2D |
0.837 | -0.127 | -3 | 0.720 |
YSK4 |
0.837 | -0.083 | 1 | 0.756 |
NUAK1 |
0.837 | -0.053 | -3 | 0.665 |
MAPKAPK2 |
0.837 | -0.045 | -3 | 0.611 |
ACVR2A |
0.837 | 0.022 | -2 | 0.858 |
ACVR2B |
0.837 | 0.025 | -2 | 0.873 |
TTBK2 |
0.837 | -0.170 | 2 | 0.698 |
VRK2 |
0.836 | -0.067 | 1 | 0.895 |
LATS1 |
0.836 | -0.015 | -3 | 0.714 |
TSSK2 |
0.836 | -0.081 | -5 | 0.839 |
SMG1 |
0.836 | -0.011 | 1 | 0.821 |
CHAK1 |
0.836 | -0.046 | 2 | 0.775 |
CDK10 |
0.836 | 0.260 | 1 | 0.809 |
AMPKA2 |
0.835 | -0.089 | -3 | 0.692 |
TSSK1 |
0.835 | -0.076 | -3 | 0.738 |
DYRK1A |
0.835 | 0.152 | 1 | 0.891 |
ALK2 |
0.834 | 0.022 | -2 | 0.873 |
PKACG |
0.834 | -0.104 | -2 | 0.700 |
NEK5 |
0.834 | 0.086 | 1 | 0.842 |
MEK1 |
0.833 | -0.153 | 2 | 0.839 |
CDK6 |
0.833 | 0.288 | 1 | 0.806 |
PKCZ |
0.833 | -0.038 | 2 | 0.800 |
PERK |
0.833 | -0.035 | -2 | 0.907 |
PIM2 |
0.833 | 0.028 | -3 | 0.634 |
PHKG1 |
0.833 | -0.078 | -3 | 0.693 |
MEKK1 |
0.832 | -0.030 | 1 | 0.815 |
HRI |
0.832 | -0.041 | -2 | 0.908 |
RSK4 |
0.832 | -0.016 | -3 | 0.626 |
MEKK2 |
0.832 | -0.002 | 2 | 0.820 |
TLK2 |
0.832 | -0.069 | 1 | 0.821 |
MELK |
0.831 | -0.095 | -3 | 0.682 |
QIK |
0.831 | -0.134 | -3 | 0.714 |
HIPK3 |
0.831 | 0.161 | 1 | 0.864 |
PRKD3 |
0.831 | -0.054 | -3 | 0.627 |
PKCH |
0.831 | -0.034 | 2 | 0.751 |
AURC |
0.831 | -0.052 | -2 | 0.582 |
CAMK2B |
0.830 | -0.077 | 2 | 0.767 |
BRAF |
0.830 | 0.006 | -4 | 0.840 |
QSK |
0.830 | -0.083 | 4 | 0.809 |
DNAPK |
0.830 | 0.009 | 1 | 0.732 |
MST3 |
0.830 | 0.052 | 2 | 0.863 |
ZAK |
0.830 | -0.041 | 1 | 0.770 |
ERK7 |
0.829 | 0.136 | 2 | 0.580 |
DYRK1B |
0.829 | 0.187 | 1 | 0.825 |
AKT2 |
0.829 | -0.006 | -3 | 0.584 |
MEKK3 |
0.829 | -0.085 | 1 | 0.796 |
IRAK4 |
0.829 | -0.011 | 1 | 0.814 |
DYRK4 |
0.829 | 0.204 | 1 | 0.806 |
BMPR1A |
0.829 | 0.048 | 1 | 0.745 |
PLK3 |
0.828 | -0.071 | 2 | 0.745 |
MSK2 |
0.828 | -0.110 | -3 | 0.632 |
MEK5 |
0.827 | -0.149 | 2 | 0.830 |
CAMK4 |
0.827 | -0.200 | -3 | 0.686 |
MNK2 |
0.827 | -0.102 | -2 | 0.750 |
SIK |
0.827 | -0.095 | -3 | 0.635 |
CDK4 |
0.826 | 0.257 | 1 | 0.790 |
MPSK1 |
0.826 | 0.059 | 1 | 0.840 |
PAK1 |
0.826 | -0.131 | -2 | 0.733 |
CAMK2A |
0.826 | -0.084 | 2 | 0.792 |
TAO3 |
0.825 | -0.015 | 1 | 0.801 |
JNK1 |
0.825 | 0.219 | 1 | 0.778 |
GRK2 |
0.825 | -0.067 | -2 | 0.789 |
CK1E |
0.825 | -0.053 | -3 | 0.462 |
PAK3 |
0.825 | -0.160 | -2 | 0.738 |
DYRK3 |
0.825 | 0.122 | 1 | 0.870 |
MNK1 |
0.824 | -0.083 | -2 | 0.762 |
NEK8 |
0.824 | 0.024 | 2 | 0.831 |
PKACB |
0.824 | -0.049 | -2 | 0.608 |
MYLK4 |
0.824 | -0.097 | -2 | 0.726 |
PAK6 |
0.823 | -0.056 | -2 | 0.658 |
CHK1 |
0.823 | -0.128 | -3 | 0.696 |
GAK |
0.823 | 0.082 | 1 | 0.866 |
PKG2 |
0.823 | -0.068 | -2 | 0.609 |
MARK3 |
0.822 | -0.096 | 4 | 0.769 |
DRAK1 |
0.822 | -0.107 | 1 | 0.730 |
AURB |
0.822 | -0.077 | -2 | 0.586 |
SGK3 |
0.822 | -0.062 | -3 | 0.645 |
MARK2 |
0.822 | -0.106 | 4 | 0.729 |
EEF2K |
0.821 | 0.098 | 3 | 0.873 |
CAMKK1 |
0.821 | -0.028 | -2 | 0.838 |
PRKX |
0.821 | -0.023 | -3 | 0.561 |
WNK4 |
0.821 | -0.116 | -2 | 0.875 |
PLK4 |
0.821 | -0.136 | 2 | 0.606 |
MSK1 |
0.820 | -0.088 | -3 | 0.637 |
TAO2 |
0.820 | -0.007 | 2 | 0.861 |
PKCT |
0.820 | -0.044 | 2 | 0.758 |
TLK1 |
0.819 | -0.132 | -2 | 0.893 |
CAMK1G |
0.819 | -0.095 | -3 | 0.647 |
DCAMKL1 |
0.819 | -0.098 | -3 | 0.656 |
MAPKAPK5 |
0.819 | -0.154 | -3 | 0.631 |
MAK |
0.819 | 0.175 | -2 | 0.710 |
BRSK1 |
0.818 | -0.149 | -3 | 0.665 |
SNRK |
0.818 | -0.218 | 2 | 0.662 |
PAK2 |
0.818 | -0.167 | -2 | 0.727 |
PASK |
0.818 | -0.055 | -3 | 0.724 |
BRSK2 |
0.818 | -0.175 | -3 | 0.686 |
LKB1 |
0.818 | -0.004 | -3 | 0.757 |
AKT1 |
0.818 | -0.020 | -3 | 0.598 |
TNIK |
0.818 | 0.076 | 3 | 0.890 |
CK1D |
0.818 | -0.042 | -3 | 0.414 |
NEK4 |
0.817 | 0.033 | 1 | 0.791 |
SMMLCK |
0.817 | -0.080 | -3 | 0.698 |
GSK3A |
0.817 | 0.025 | 4 | 0.413 |
PHKG2 |
0.817 | -0.073 | -3 | 0.665 |
MST2 |
0.816 | -0.038 | 1 | 0.795 |
PKCI |
0.816 | -0.025 | 2 | 0.773 |
MARK1 |
0.816 | -0.137 | 4 | 0.791 |
HGK |
0.816 | 0.036 | 3 | 0.881 |
MINK |
0.816 | 0.028 | 1 | 0.781 |
GCK |
0.815 | -0.019 | 1 | 0.789 |
TAK1 |
0.815 | 0.013 | 1 | 0.824 |
IRAK1 |
0.815 | -0.164 | -1 | 0.773 |
MOK |
0.815 | 0.153 | 1 | 0.876 |
NEK11 |
0.814 | -0.131 | 1 | 0.780 |
P70S6K |
0.814 | -0.067 | -3 | 0.605 |
PKCE |
0.814 | 0.011 | 2 | 0.753 |
NEK1 |
0.813 | 0.078 | 1 | 0.805 |
AURA |
0.813 | -0.100 | -2 | 0.558 |
CAMKK2 |
0.813 | -0.086 | -2 | 0.822 |
CK2A2 |
0.811 | 0.036 | 1 | 0.680 |
CK1G1 |
0.811 | -0.109 | -3 | 0.443 |
GSK3B |
0.811 | -0.052 | 4 | 0.403 |
SSTK |
0.810 | -0.110 | 4 | 0.804 |
MEKK6 |
0.810 | -0.069 | 1 | 0.809 |
GRK3 |
0.810 | -0.071 | -2 | 0.745 |
LRRK2 |
0.810 | -0.063 | 2 | 0.851 |
TTBK1 |
0.810 | -0.171 | 2 | 0.609 |
CK1A2 |
0.810 | -0.068 | -3 | 0.414 |
PDK1 |
0.809 | -0.110 | 1 | 0.792 |
DCAMKL2 |
0.809 | -0.134 | -3 | 0.681 |
MST1 |
0.807 | -0.062 | 1 | 0.781 |
DAPK3 |
0.807 | -0.069 | -3 | 0.671 |
TTK |
0.807 | 0.092 | -2 | 0.886 |
AKT3 |
0.807 | -0.012 | -3 | 0.530 |
PKACA |
0.807 | -0.074 | -2 | 0.543 |
KHS2 |
0.806 | 0.041 | 1 | 0.781 |
PKN1 |
0.806 | -0.046 | -3 | 0.619 |
VRK1 |
0.806 | -0.099 | 2 | 0.847 |
HPK1 |
0.806 | -0.047 | 1 | 0.764 |
MAP3K15 |
0.806 | -0.121 | 1 | 0.761 |
LOK |
0.806 | -0.060 | -2 | 0.791 |
KHS1 |
0.805 | 0.000 | 1 | 0.767 |
YSK1 |
0.804 | -0.015 | 2 | 0.835 |
PLK2 |
0.804 | -0.052 | -3 | 0.692 |
CHK2 |
0.803 | -0.054 | -3 | 0.532 |
PDHK3_TYR |
0.803 | 0.115 | 4 | 0.878 |
CAMK1D |
0.802 | -0.114 | -3 | 0.567 |
OSR1 |
0.801 | 0.002 | 2 | 0.816 |
CK2A1 |
0.801 | 0.016 | 1 | 0.654 |
PBK |
0.801 | -0.001 | 1 | 0.810 |
NEK3 |
0.801 | -0.014 | 1 | 0.770 |
SLK |
0.801 | -0.092 | -2 | 0.755 |
PAK5 |
0.800 | -0.121 | -2 | 0.586 |
SGK1 |
0.800 | -0.030 | -3 | 0.515 |
MRCKB |
0.800 | -0.046 | -3 | 0.617 |
STK33 |
0.799 | -0.124 | 2 | 0.597 |
ROCK2 |
0.799 | -0.042 | -3 | 0.662 |
DAPK1 |
0.797 | -0.097 | -3 | 0.660 |
RIPK2 |
0.797 | -0.189 | 1 | 0.724 |
PDHK4_TYR |
0.797 | 0.065 | 2 | 0.867 |
MEK2 |
0.797 | -0.176 | 2 | 0.811 |
MRCKA |
0.797 | -0.067 | -3 | 0.629 |
BUB1 |
0.797 | -0.019 | -5 | 0.773 |
TESK1_TYR |
0.796 | -0.012 | 3 | 0.877 |
MYO3B |
0.796 | 0.049 | 2 | 0.841 |
PAK4 |
0.795 | -0.115 | -2 | 0.586 |
SBK |
0.794 | -0.025 | -3 | 0.479 |
BMPR2_TYR |
0.793 | 0.037 | -1 | 0.905 |
MAP2K4_TYR |
0.793 | -0.060 | -1 | 0.892 |
MAP2K6_TYR |
0.793 | -0.031 | -1 | 0.904 |
PKMYT1_TYR |
0.793 | -0.028 | 3 | 0.845 |
DMPK1 |
0.793 | -0.020 | -3 | 0.631 |
MYO3A |
0.792 | 0.011 | 1 | 0.782 |
BIKE |
0.790 | 0.034 | 1 | 0.752 |
CAMK1A |
0.790 | -0.101 | -3 | 0.540 |
PDHK1_TYR |
0.790 | -0.058 | -1 | 0.909 |
MAP2K7_TYR |
0.790 | -0.201 | 2 | 0.851 |
PINK1_TYR |
0.790 | -0.098 | 1 | 0.847 |
LIMK2_TYR |
0.789 | 0.001 | -3 | 0.770 |
TAO1 |
0.788 | -0.051 | 1 | 0.722 |
HASPIN |
0.787 | -0.045 | -1 | 0.668 |
EPHA6 |
0.787 | 0.041 | -1 | 0.900 |
ROCK1 |
0.786 | -0.058 | -3 | 0.631 |
BLK |
0.785 | 0.145 | -1 | 0.875 |
TXK |
0.785 | 0.068 | 1 | 0.814 |
LCK |
0.784 | 0.108 | -1 | 0.872 |
ROS1 |
0.784 | -0.039 | 3 | 0.789 |
ASK1 |
0.784 | -0.134 | 1 | 0.741 |
TYK2 |
0.783 | -0.088 | 1 | 0.802 |
MST1R |
0.783 | -0.067 | 3 | 0.815 |
LIMK1_TYR |
0.783 | -0.128 | 2 | 0.852 |
EPHB4 |
0.783 | -0.014 | -1 | 0.883 |
TYRO3 |
0.783 | -0.083 | 3 | 0.810 |
CSF1R |
0.782 | -0.033 | 3 | 0.799 |
YES1 |
0.782 | -0.006 | -1 | 0.878 |
HCK |
0.782 | 0.041 | -1 | 0.872 |
FGR |
0.782 | -0.039 | 1 | 0.852 |
ABL2 |
0.782 | -0.001 | -1 | 0.834 |
RET |
0.782 | -0.139 | 1 | 0.809 |
CRIK |
0.782 | -0.043 | -3 | 0.596 |
JAK2 |
0.780 | -0.090 | 1 | 0.803 |
ALPHAK3 |
0.779 | -0.111 | -1 | 0.796 |
PKG1 |
0.778 | -0.125 | -2 | 0.505 |
JAK3 |
0.777 | -0.064 | 1 | 0.783 |
TNNI3K_TYR |
0.777 | 0.034 | 1 | 0.841 |
ABL1 |
0.777 | -0.024 | -1 | 0.824 |
ITK |
0.777 | -0.023 | -1 | 0.844 |
INSRR |
0.776 | -0.071 | 3 | 0.756 |
AAK1 |
0.776 | 0.074 | 1 | 0.663 |
FER |
0.775 | -0.124 | 1 | 0.857 |
CK1A |
0.775 | -0.093 | -3 | 0.331 |
TNK2 |
0.775 | -0.029 | 3 | 0.760 |
STLK3 |
0.775 | -0.164 | 1 | 0.740 |
YANK3 |
0.773 | -0.119 | 2 | 0.372 |
DDR1 |
0.773 | -0.192 | 4 | 0.804 |
KDR |
0.773 | -0.042 | 3 | 0.772 |
JAK1 |
0.772 | -0.004 | 1 | 0.732 |
TEC |
0.772 | -0.014 | -1 | 0.775 |
SRMS |
0.772 | -0.088 | 1 | 0.823 |
EPHA4 |
0.772 | -0.060 | 2 | 0.746 |
KIT |
0.772 | -0.101 | 3 | 0.794 |
PDGFRB |
0.771 | -0.133 | 3 | 0.814 |
EPHB1 |
0.771 | -0.064 | 1 | 0.823 |
FYN |
0.771 | 0.041 | -1 | 0.858 |
EPHB3 |
0.770 | -0.064 | -1 | 0.873 |
FLT3 |
0.770 | -0.108 | 3 | 0.805 |
EPHB2 |
0.770 | -0.046 | -1 | 0.861 |
WEE1_TYR |
0.770 | -0.026 | -1 | 0.766 |
BMX |
0.769 | -0.039 | -1 | 0.768 |
FGFR2 |
0.769 | -0.135 | 3 | 0.786 |
MET |
0.768 | -0.080 | 3 | 0.783 |
LYN |
0.768 | -0.013 | 3 | 0.733 |
BTK |
0.768 | -0.117 | -1 | 0.804 |
NEK10_TYR |
0.767 | -0.114 | 1 | 0.672 |
TNK1 |
0.767 | -0.118 | 3 | 0.786 |
TEK |
0.767 | -0.127 | 3 | 0.743 |
MERTK |
0.765 | -0.089 | 3 | 0.769 |
AXL |
0.764 | -0.128 | 3 | 0.781 |
FLT1 |
0.764 | -0.078 | -1 | 0.866 |
FGFR1 |
0.764 | -0.161 | 3 | 0.766 |
PDGFRA |
0.762 | -0.190 | 3 | 0.813 |
EPHA7 |
0.762 | -0.065 | 2 | 0.748 |
FRK |
0.761 | -0.072 | -1 | 0.865 |
ALK |
0.761 | -0.156 | 3 | 0.717 |
INSR |
0.760 | -0.128 | 3 | 0.743 |
LTK |
0.760 | -0.141 | 3 | 0.731 |
PTK6 |
0.759 | -0.204 | -1 | 0.759 |
NTRK2 |
0.759 | -0.154 | 3 | 0.765 |
SRC |
0.759 | -0.046 | -1 | 0.845 |
ERBB2 |
0.759 | -0.155 | 1 | 0.746 |
NTRK1 |
0.758 | -0.196 | -1 | 0.856 |
FGFR3 |
0.758 | -0.139 | 3 | 0.766 |
EPHA3 |
0.758 | -0.127 | 2 | 0.717 |
DDR2 |
0.758 | -0.071 | 3 | 0.740 |
EPHA1 |
0.758 | -0.104 | 3 | 0.764 |
PTK2 |
0.756 | 0.025 | -1 | 0.859 |
FLT4 |
0.755 | -0.167 | 3 | 0.753 |
NTRK3 |
0.754 | -0.144 | -1 | 0.809 |
CK1G3 |
0.754 | -0.099 | -3 | 0.287 |
MATK |
0.754 | -0.132 | -1 | 0.745 |
EPHA5 |
0.753 | -0.086 | 2 | 0.727 |
EPHA8 |
0.753 | -0.085 | -1 | 0.860 |
PTK2B |
0.752 | -0.106 | -1 | 0.800 |
EGFR |
0.749 | -0.109 | 1 | 0.649 |
SYK |
0.749 | -0.022 | -1 | 0.828 |
YANK2 |
0.745 | -0.126 | 2 | 0.392 |
FGFR4 |
0.745 | -0.134 | -1 | 0.793 |
CSK |
0.742 | -0.209 | 2 | 0.752 |
IGF1R |
0.742 | -0.146 | 3 | 0.679 |
MUSK |
0.742 | -0.132 | 1 | 0.645 |
EPHA2 |
0.742 | -0.088 | -1 | 0.828 |
ERBB4 |
0.739 | -0.076 | 1 | 0.656 |
CK1G2 |
0.733 | -0.098 | -3 | 0.369 |
ZAP70 |
0.728 | -0.065 | -1 | 0.754 |
FES |
0.727 | -0.164 | -1 | 0.738 |