Motif 634 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NCL7 | ANKRD33B | S44 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| A6ND36 | FAM83G | S688 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O14639 | ABLIM1 | S540 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O15067 | PFAS | S540 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15069 | NACAD | S406 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O15119 | TBX3 | S354 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O43166 | SIPA1L1 | S1390 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43314 | PPIP5K2 | S1110 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43581 | SYT7 | S105 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O43815 | STRN | S259 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60347 | TBC1D12 | S315 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O75044 | SRGAP2 | S822 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75427 | LRCH4 | S346 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O95239 | KIF4A | S507 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95359 | TACC2 | S749 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95747 | OXSR1 | S425 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| P00533 | EGFR | S1162 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02671 | FGA | S551 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P07195 | LDHB | S85 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07384 | CAPN1 | S474 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P08151 | GLI1 | S204 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P08237 | PFKM | S377 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P09629 | HOXB7 | S133 | psp | Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P10636 | MAPT | S288 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P16615 | ATP2A2 | S553 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P17858 | PFKL | S377 | ochoa | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). {ECO:0000250|UniProtKB:P12382, ECO:0000255|HAMAP-Rule:MF_03184, ECO:0000269|PubMed:22923583}. |
| P19429 | TNNI3 | S44 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P22314 | UBA1 | S793 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P22626 | HNRNPA2B1 | S189 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P25705 | ATP5F1A | S462 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P28290 | ITPRID2 | S410 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29375 | KDM5A | S287 | psp | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P35573 | AGL | S738 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P40121 | CAPG | S318 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P42694 | HELZ | S1442 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P46821 | MAP1B | S2007 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P52943 | CRIP2 | S104 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P54132 | BLM | S580 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54821 | PRRX1 | S67 | ochoa | Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). {ECO:0000250|UniProtKB:P63013, ECO:0000269|PubMed:35589735}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}. |
| P55036 | PSMD4 | S266 | ochoa | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| P56589 | PEX3 | S254 | ochoa | Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) | Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:15007061}. |
| Q04206 | RELA | S205 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q13023 | AKAP6 | S1983 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13151 | HNRNPA0 | S68 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13554 | CAMK2B | S358 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q14566 | MCM6 | S718 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14D04 | VEPH1 | S380 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15084 | PDIA6 | S259 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15849 | SLC14A2 | S477 | psp | Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney) | [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:17702749}.; FUNCTION: [Isoform 2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:8647271, ECO:0000269|PubMed:8997401}. |
| Q16643 | DBN1 | S134 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q49A88 | CCDC14 | S751 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q5JSL3 | DOCK11 | S296 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5JTC6 | AMER1 | S674 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T5P2 | KIAA1217 | S1259 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TCY1 | TTBK1 | S515 | ochoa | Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) | Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}. |
| Q5VUB5 | FAM171A1 | S511 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q6DN12 | MCTP2 | S134 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6DN12 | MCTP2 | S135 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6UXK2 | ISLR2 | S650 | ochoa | Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein) | Required for axon extension during neural development. {ECO:0000250}. |
| Q6WCQ1 | MPRIP | S662 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZUM4 | ARHGAP27 | S625 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q86TB3 | ALPK2 | S1698 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
| Q86XL3 | ANKLE2 | S662 | ochoa|psp | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IVL0 | NAV3 | S654 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IVT2 | MISP | S67 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWR0 | ZC3H7A | S780 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8IZD4 | DCP1B | S67 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8IZT6 | ASPM | S190 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N5A5 | ZGPAT | S373 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N7H5 | PAF1 | S147 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
| Q8TBX8 | PIP4K2C | S328 | psp | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}. |
| Q8TDX7 | NEK7 | S188 | ochoa | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:31409757, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}. |
| Q8TDY4 | ASAP3 | S729 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) | Promotes cell proliferation. {ECO:0000269|PubMed:14654939}. |
| Q8WWA1 | TMEM40 | S141 | ochoa | Transmembrane protein 40 | None |
| Q8WWI1 | LMO7 | S1388 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WYP5 | AHCTF1 | S1463 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92598 | HSPH1 | T486 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q969F2 | NKD2 | S286 | ochoa | Protein naked cuticle homolog 2 (Naked-2) (hNkd2) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
| Q96GS4 | BORCS6 | S61 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96H22 | CENPN | S226 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96R06 | SPAG5 | S944 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96ST2 | IWS1 | S415 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q99623 | PHB2 | S151 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BYE7 | PCGF6 | S232 | ochoa | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}. |
| Q9H714 | RUBCNL | S189 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9HAU0 | PLEKHA5 | S410 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HC44 | GPBP1L1 | S216 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9HC98 | NEK6 | S199 | ochoa | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}. |
| Q9NPI6 | DCP1A | S62 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NRW4 | DUSP22 | S58 | ochoa | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). {ECO:0000250|UniProtKB:Q99N11, ECO:0000269|PubMed:11717427, ECO:0000269|PubMed:24714587, ECO:0000269|PubMed:38225265}. |
| Q9NWQ8 | PAG1 | S201 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NYQ7 | CELSR3 | S3068 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZT2 | OGFR | S420 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P0L2 | MARK1 | S649 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UGU0 | TCF20 | S1418 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UKV3 | ACIN1 | S749 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UNZ2 | NSFL1C | S140 | ochoa|psp | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN4 | CEP131 | S450 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y2H5 | PLEKHA6 | S794 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y446 | PKP3 | S80 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4A5 | TRRAP | S2530 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| Q9Y4K4 | MAP4K5 | S335 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
| Q9Y4W2 | LAS1L | S249 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y597 | KCTD3 | S664 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5J3 | HEY1 | S40 | ochoa | Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1) | Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}. |
| Q9Y657 | SPIN1 | S124 | ochoa|psp | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q9Y6A5 | TACC3 | S501 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6J0 | CABIN1 | S1471 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| V9GY48 | None | S259 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein | None |
| Q7Z4H3 | HDDC2 | S170 | Sugiyama | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}. |
| Q8WVM8 | SCFD1 | S347 | Sugiyama | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q9Y230 | RUVBL2 | S43 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| O75914 | PAK3 | S246 | Sugiyama | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| P23142 | FBLN1 | S247 | Sugiyama | Fibulin-1 (FIBL-1) | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| O14646 | CHD1 | S1017 | Sugiyama | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O43526 | KCNQ2 | S551 | SIGNOR|iPTMNet|EPSD | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O76070 | SNCG | S92 | Sugiyama | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| Q9Y266 | NUDC | S60 | Sugiyama | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| O00625 | PIR | S225 | Sugiyama | Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase) | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:15951572, ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}. |
| Q9H3D4 | TP63 | S310 | SIGNOR | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q92598 | HSPH1 | S65 | Sugiyama | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q8IWZ3 | ANKHD1 | S1131 | Sugiyama | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q9NQS7 | INCENP | S518 | EPSD|PSP | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| O15397 | IPO8 | S29 | Sugiyama | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000256 | 3.592 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.000664 | 3.178 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000527 | 3.278 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.002231 | 2.652 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.002807 | 2.552 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.002235 | 2.651 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.003930 | 2.406 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.005199 | 2.284 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.004908 | 2.309 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.008533 | 2.069 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.007541 | 2.123 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.009046 | 2.044 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.009046 | 2.044 |
| R-HSA-68886 | M Phase | 0.008225 | 2.085 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.041950 | 1.377 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.050129 | 1.300 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.066277 | 1.179 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.066277 | 1.179 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.066277 | 1.179 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.074249 | 1.129 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.013039 | 1.885 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.089991 | 1.046 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.097761 | 1.010 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.113106 | 0.947 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.113106 | 0.947 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.113106 | 0.947 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.120681 | 0.918 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.120681 | 0.918 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.128191 | 0.892 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.128191 | 0.892 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.128191 | 0.892 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.128191 | 0.892 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.128191 | 0.892 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.128191 | 0.892 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.135638 | 0.868 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.143022 | 0.845 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.150343 | 0.823 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.150343 | 0.823 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.150343 | 0.823 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.157602 | 0.802 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.171936 | 0.765 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.186028 | 0.730 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.025393 | 1.595 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.192984 | 0.714 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.192984 | 0.714 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.192984 | 0.714 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.192984 | 0.714 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.192984 | 0.714 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.199882 | 0.699 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.206720 | 0.685 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.206720 | 0.685 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.206720 | 0.685 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.213501 | 0.671 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.233500 | 0.632 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.259382 | 0.586 |
| R-HSA-390522 | Striated Muscle Contraction | 0.290518 | 0.537 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.239936 | 0.620 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.240054 | 0.620 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.199882 | 0.699 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.199882 | 0.699 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.171936 | 0.765 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.171936 | 0.765 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.265716 | 0.576 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.179012 | 0.747 |
| R-HSA-182971 | EGFR downregulation | 0.271996 | 0.565 |
| R-HSA-177929 | Signaling by EGFR | 0.104956 | 0.979 |
| R-HSA-180292 | GAB1 signalosome | 0.016959 | 1.771 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.226891 | 0.644 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.259382 | 0.586 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.066727 | 1.176 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.078868 | 1.103 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.078868 | 1.103 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.078868 | 1.103 |
| R-HSA-9620244 | Long-term potentiation | 0.233500 | 0.632 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.290518 | 0.537 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.128191 | 0.892 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.252994 | 0.597 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.265716 | 0.576 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.284396 | 0.546 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.284396 | 0.546 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.046492 | 1.333 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.091636 | 1.038 |
| R-HSA-354192 | Integrin signaling | 0.284396 | 0.546 |
| R-HSA-8949664 | Processing of SMDT1 | 0.135638 | 0.868 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.265716 | 0.576 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.206720 | 0.685 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.015752 | 1.803 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.144637 | 0.840 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.042617 | 1.370 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.078868 | 1.103 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.296587 | 0.528 |
| R-HSA-176974 | Unwinding of DNA | 0.097761 | 1.010 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.105466 | 0.977 |
| R-HSA-4839744 | Signaling by APC mutants | 0.113106 | 0.947 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.120681 | 0.918 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.120681 | 0.918 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.150343 | 0.823 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.150343 | 0.823 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.050933 | 1.293 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.164800 | 0.783 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.206720 | 0.685 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.094258 | 1.026 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.226891 | 0.644 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.096901 | 1.014 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.246552 | 0.608 |
| R-HSA-8949613 | Cristae formation | 0.246552 | 0.608 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.252994 | 0.597 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.296587 | 0.528 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.224192 | 0.649 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.027757 | 1.557 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.171936 | 0.765 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.114183 | 0.942 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.082153 | 1.085 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.240054 | 0.620 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.271996 | 0.565 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.147582 | 0.831 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.135638 | 0.868 |
| R-HSA-8852135 | Protein ubiquitination | 0.035116 | 1.454 |
| R-HSA-9609507 | Protein localization | 0.181817 | 0.740 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.062064 | 1.207 |
| R-HSA-5260271 | Diseases of Immune System | 0.062064 | 1.207 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.156488 | 0.806 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.082153 | 1.085 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.014296 | 1.845 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.120681 | 0.918 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.186028 | 0.730 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.174588 | 0.758 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.035808 | 1.446 |
| R-HSA-68882 | Mitotic Anaphase | 0.053357 | 1.273 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.246251 | 0.609 |
| R-HSA-3371556 | Cellular response to heat stress | 0.110559 | 0.956 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.029524 | 1.530 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.054140 | 1.266 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.206720 | 0.685 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.129118 | 0.889 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.074249 | 1.129 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.143022 | 0.845 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.246552 | 0.608 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.246552 | 0.608 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.265716 | 0.576 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.284396 | 0.546 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.302605 | 0.519 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.249411 | 0.603 |
| R-HSA-3928664 | Ephrin signaling | 0.179012 | 0.747 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.199198 | 0.701 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.252572 | 0.598 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.066277 | 1.179 |
| R-HSA-428540 | Activation of RAC1 | 0.120681 | 0.918 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.150343 | 0.823 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.094258 | 1.026 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.246552 | 0.608 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.271996 | 0.565 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.072268 | 1.141 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.017509 | 1.757 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.105466 | 0.977 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.107681 | 0.968 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.284396 | 0.546 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.284396 | 0.546 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.252572 | 0.598 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.213501 | 0.671 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.058237 | 1.235 |
| R-HSA-448706 | Interleukin-1 processing | 0.097761 | 1.010 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.097761 | 1.010 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.024448 | 1.612 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.113106 | 0.947 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.135638 | 0.868 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.179012 | 0.747 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.097761 | 1.010 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.135638 | 0.868 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.150343 | 0.823 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.246552 | 0.608 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.094258 | 1.026 |
| R-HSA-73886 | Chromosome Maintenance | 0.110559 | 0.956 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.150343 | 0.823 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.246552 | 0.608 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.271996 | 0.565 |
| R-HSA-3371511 | HSF1 activation | 0.308572 | 0.511 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.030250 | 1.519 |
| R-HSA-1640170 | Cell Cycle | 0.023317 | 1.632 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.192984 | 0.714 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.226891 | 0.644 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.226891 | 0.644 |
| R-HSA-202403 | TCR signaling | 0.088162 | 1.055 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.220224 | 0.657 |
| R-HSA-69190 | DNA strand elongation | 0.278223 | 0.556 |
| R-HSA-3214847 | HATs acetylate histones | 0.243093 | 0.614 |
| R-HSA-111933 | Calmodulin induced events | 0.308572 | 0.511 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.186028 | 0.730 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.233500 | 0.632 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.246552 | 0.608 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.259382 | 0.586 |
| R-HSA-111997 | CaM pathway | 0.308572 | 0.511 |
| R-HSA-8939211 | ESR-mediated signaling | 0.071191 | 1.148 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.157602 | 0.802 |
| R-HSA-5578775 | Ion homeostasis | 0.018080 | 1.743 |
| R-HSA-3214842 | HDMs demethylate histones | 0.233500 | 0.632 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.127253 | 0.895 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.014296 | 1.845 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.021315 | 1.671 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.086458 | 1.063 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.284396 | 0.546 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.033284 | 1.478 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.265716 | 0.576 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.089991 | 1.046 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.097761 | 1.010 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.034069 | 1.468 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.113186 | 0.946 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.252994 | 0.597 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.115966 | 0.936 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.115966 | 0.936 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.115966 | 0.936 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.115966 | 0.936 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.038671 | 1.413 |
| R-HSA-445144 | Signal transduction by L1 | 0.192984 | 0.714 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.220224 | 0.657 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.189915 | 0.721 |
| R-HSA-5576891 | Cardiac conduction | 0.132956 | 0.876 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.150343 | 0.823 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.206720 | 0.685 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.220224 | 0.657 |
| R-HSA-5620971 | Pyroptosis | 0.252994 | 0.597 |
| R-HSA-5673000 | RAF activation | 0.296587 | 0.528 |
| R-HSA-162582 | Signal Transduction | 0.085868 | 1.066 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.296587 | 0.528 |
| R-HSA-373760 | L1CAM interactions | 0.101701 | 0.993 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.232592 | 0.633 |
| R-HSA-180786 | Extension of Telomeres | 0.113186 | 0.946 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.284396 | 0.546 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.296836 | 0.527 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.308572 | 0.511 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.196890 | 0.706 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.022803 | 1.642 |
| R-HSA-157118 | Signaling by NOTCH | 0.073978 | 1.131 |
| R-HSA-157579 | Telomere Maintenance | 0.236782 | 0.626 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.174807 | 0.757 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.186028 | 0.730 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.042617 | 1.370 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.115966 | 0.936 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.162481 | 0.789 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.296767 | 0.528 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.312579 | 0.505 |
| R-HSA-4839726 | Chromatin organization | 0.200526 | 0.698 |
| R-HSA-422475 | Axon guidance | 0.213352 | 0.671 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.073932 | 1.131 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.144705 | 0.840 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.302605 | 0.519 |
| R-HSA-70171 | Glycolysis | 0.246251 | 0.609 |
| R-HSA-9675108 | Nervous system development | 0.260276 | 0.585 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.271554 | 0.566 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.252994 | 0.597 |
| R-HSA-9733709 | Cardiogenesis | 0.284396 | 0.546 |
| R-HSA-622312 | Inflammasomes | 0.252994 | 0.597 |
| R-HSA-75153 | Apoptotic execution phase | 0.078868 | 1.103 |
| R-HSA-1483255 | PI Metabolism | 0.073932 | 1.131 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.271554 | 0.566 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.308572 | 0.511 |
| R-HSA-5357801 | Programmed Cell Death | 0.303760 | 0.517 |
| R-HSA-109581 | Apoptosis | 0.201253 | 0.696 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.130114 | 0.886 |
| R-HSA-70326 | Glucose metabolism | 0.309436 | 0.509 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.196097 | 0.708 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.214785 | 0.668 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.162481 | 0.789 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.199198 | 0.701 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.314488 | 0.502 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.314488 | 0.502 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.314488 | 0.502 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.315720 | 0.501 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.315720 | 0.501 |
| R-HSA-68875 | Mitotic Prophase | 0.318857 | 0.496 |
| R-HSA-397014 | Muscle contraction | 0.320102 | 0.495 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.320353 | 0.494 |
| R-HSA-1566948 | Elastic fibre formation | 0.320353 | 0.494 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.320353 | 0.494 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.325122 | 0.488 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.325122 | 0.488 |
| R-HSA-1266738 | Developmental Biology | 0.325842 | 0.487 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.326169 | 0.487 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.326169 | 0.487 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.328249 | 0.484 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.331372 | 0.480 |
| R-HSA-3371568 | Attenuation phase | 0.331936 | 0.479 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.331936 | 0.479 |
| R-HSA-202433 | Generation of second messenger molecules | 0.331936 | 0.479 |
| R-HSA-8982491 | Glycogen metabolism | 0.331936 | 0.479 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.337653 | 0.472 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.337653 | 0.472 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.337653 | 0.472 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.337653 | 0.472 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.337653 | 0.472 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.337653 | 0.472 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.343322 | 0.464 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.343322 | 0.464 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.343322 | 0.464 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.343322 | 0.464 |
| R-HSA-69481 | G2/M Checkpoints | 0.343823 | 0.464 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.348943 | 0.457 |
| R-HSA-111996 | Ca-dependent events | 0.348943 | 0.457 |
| R-HSA-9907900 | Proteasome assembly | 0.360042 | 0.444 |
| R-HSA-373752 | Netrin-1 signaling | 0.360042 | 0.444 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.365520 | 0.437 |
| R-HSA-774815 | Nucleosome assembly | 0.365520 | 0.437 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.365520 | 0.437 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.365520 | 0.437 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.365520 | 0.437 |
| R-HSA-9675135 | Diseases of DNA repair | 0.370953 | 0.431 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.370953 | 0.431 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.370953 | 0.431 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.375922 | 0.425 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.376338 | 0.424 |
| R-HSA-437239 | Recycling pathway of L1 | 0.376338 | 0.424 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.380700 | 0.419 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.381679 | 0.418 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.383736 | 0.416 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.385612 | 0.414 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.386766 | 0.413 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.397428 | 0.401 |
| R-HSA-912446 | Meiotic recombination | 0.397428 | 0.401 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.402589 | 0.395 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.402589 | 0.395 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.407706 | 0.390 |
| R-HSA-112316 | Neuronal System | 0.408916 | 0.388 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.416692 | 0.380 |
| R-HSA-8935690 | Digestion | 0.422797 | 0.374 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.422797 | 0.374 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.425529 | 0.371 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.432646 | 0.364 |
| R-HSA-9033241 | Peroxisomal protein import | 0.437507 | 0.359 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.442327 | 0.354 |
| R-HSA-983189 | Kinesins | 0.442327 | 0.354 |
| R-HSA-112043 | PLC beta mediated events | 0.447106 | 0.350 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.451844 | 0.345 |
| R-HSA-1268020 | Mitochondrial protein import | 0.451844 | 0.345 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.456542 | 0.341 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.456542 | 0.341 |
| R-HSA-8848021 | Signaling by PTK6 | 0.456542 | 0.341 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.456542 | 0.341 |
| R-HSA-373755 | Semaphorin interactions | 0.456542 | 0.341 |
| R-HSA-8963743 | Digestion and absorption | 0.456542 | 0.341 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.461200 | 0.336 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.470398 | 0.328 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.470398 | 0.328 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.474938 | 0.323 |
| R-HSA-112040 | G-protein mediated events | 0.474938 | 0.323 |
| R-HSA-5218859 | Regulated Necrosis | 0.479439 | 0.319 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.485343 | 0.314 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.488328 | 0.311 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.488328 | 0.311 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.488328 | 0.311 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.492715 | 0.307 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.495130 | 0.305 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.496300 | 0.304 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.497065 | 0.304 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.497065 | 0.304 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.501379 | 0.300 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.501379 | 0.300 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.505655 | 0.296 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.505655 | 0.296 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.507945 | 0.294 |
| R-HSA-1483257 | Phospholipid metabolism | 0.507945 | 0.294 |
| R-HSA-2559583 | Cellular Senescence | 0.509788 | 0.293 |
| R-HSA-380287 | Centrosome maturation | 0.509895 | 0.293 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.509895 | 0.293 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.510065 | 0.292 |
| R-HSA-195721 | Signaling by WNT | 0.514290 | 0.289 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.517767 | 0.286 |
| R-HSA-216083 | Integrin cell surface interactions | 0.522399 | 0.282 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.526497 | 0.279 |
| R-HSA-9833482 | PKR-mediated signaling | 0.530559 | 0.275 |
| R-HSA-983712 | Ion channel transport | 0.533469 | 0.273 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.534587 | 0.272 |
| R-HSA-977225 | Amyloid fiber formation | 0.534587 | 0.272 |
| R-HSA-2262752 | Cellular responses to stress | 0.535668 | 0.271 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.538581 | 0.269 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.538625 | 0.269 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.546287 | 0.263 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.546466 | 0.262 |
| R-HSA-1500620 | Meiosis | 0.550359 | 0.259 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.550359 | 0.259 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.558044 | 0.253 |
| R-HSA-70268 | Pyruvate metabolism | 0.561838 | 0.250 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.565599 | 0.247 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.565599 | 0.247 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.569328 | 0.245 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.573026 | 0.242 |
| R-HSA-202424 | Downstream TCR signaling | 0.573026 | 0.242 |
| R-HSA-72172 | mRNA Splicing | 0.573621 | 0.241 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.576692 | 0.239 |
| R-HSA-6805567 | Keratinization | 0.578461 | 0.238 |
| R-HSA-1474244 | Extracellular matrix organization | 0.581086 | 0.236 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.583931 | 0.234 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.587504 | 0.231 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.591046 | 0.228 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.592743 | 0.227 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.594559 | 0.226 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.601494 | 0.221 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.601494 | 0.221 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.601494 | 0.221 |
| R-HSA-1296071 | Potassium Channels | 0.601494 | 0.221 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.608311 | 0.216 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.608311 | 0.216 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.608311 | 0.216 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.611676 | 0.213 |
| R-HSA-8951664 | Neddylation | 0.613491 | 0.212 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.615013 | 0.211 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.618321 | 0.209 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.628076 | 0.202 |
| R-HSA-111885 | Opioid Signalling | 0.628076 | 0.202 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.628076 | 0.202 |
| R-HSA-9833110 | RSV-host interactions | 0.631273 | 0.200 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.634442 | 0.198 |
| R-HSA-418346 | Platelet homeostasis | 0.637584 | 0.195 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.637584 | 0.195 |
| R-HSA-69239 | Synthesis of DNA | 0.640700 | 0.193 |
| R-HSA-211000 | Gene Silencing by RNA | 0.640700 | 0.193 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.643789 | 0.191 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.643789 | 0.191 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.646851 | 0.189 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.646851 | 0.189 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.649887 | 0.187 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.649887 | 0.187 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.655882 | 0.183 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.655882 | 0.183 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.655882 | 0.183 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.658842 | 0.181 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.658842 | 0.181 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.661776 | 0.179 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.661776 | 0.179 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.667568 | 0.176 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.667568 | 0.176 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.670428 | 0.174 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.674813 | 0.171 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.675598 | 0.170 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.676074 | 0.170 |
| R-HSA-5693538 | Homology Directed Repair | 0.678861 | 0.168 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.681624 | 0.166 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.686541 | 0.163 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.687079 | 0.163 |
| R-HSA-597592 | Post-translational protein modification | 0.691823 | 0.160 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.692441 | 0.160 |
| R-HSA-69206 | G1/S Transition | 0.700315 | 0.155 |
| R-HSA-194138 | Signaling by VEGF | 0.700315 | 0.155 |
| R-HSA-114608 | Platelet degranulation | 0.705452 | 0.152 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.708863 | 0.149 |
| R-HSA-1474165 | Reproduction | 0.715466 | 0.145 |
| R-HSA-9843745 | Adipogenesis | 0.717916 | 0.144 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.720345 | 0.142 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.720345 | 0.142 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.722754 | 0.141 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.728155 | 0.138 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.733226 | 0.135 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.750098 | 0.125 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.752252 | 0.124 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.756505 | 0.121 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.758604 | 0.120 |
| R-HSA-69242 | S Phase | 0.760685 | 0.119 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.764794 | 0.116 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.768833 | 0.114 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.768833 | 0.114 |
| R-HSA-69306 | DNA Replication | 0.770827 | 0.113 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.770827 | 0.113 |
| R-HSA-73887 | Death Receptor Signaling | 0.772803 | 0.112 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.772803 | 0.112 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.777657 | 0.109 |
| R-HSA-6798695 | Neutrophil degranulation | 0.780076 | 0.108 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.780542 | 0.108 |
| R-HSA-877300 | Interferon gamma signaling | 0.782435 | 0.107 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.789535 | 0.103 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.790811 | 0.102 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.794859 | 0.100 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.803929 | 0.095 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.807300 | 0.093 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.808964 | 0.092 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.812250 | 0.090 |
| R-HSA-1280218 | Adaptive Immune System | 0.815318 | 0.089 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.817733 | 0.087 |
| R-HSA-69275 | G2/M Transition | 0.829342 | 0.081 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.832279 | 0.080 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.832279 | 0.080 |
| R-HSA-5617833 | Cilium Assembly | 0.835167 | 0.078 |
| R-HSA-9609690 | HCMV Early Events | 0.843535 | 0.074 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.848879 | 0.071 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.848879 | 0.071 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.851482 | 0.070 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.852767 | 0.069 |
| R-HSA-8953854 | Metabolism of RNA | 0.862585 | 0.064 |
| R-HSA-913531 | Interferon Signaling | 0.863437 | 0.064 |
| R-HSA-382551 | Transport of small molecules | 0.865089 | 0.063 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.866193 | 0.062 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.875905 | 0.058 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.879960 | 0.056 |
| R-HSA-72312 | rRNA processing | 0.886582 | 0.052 |
| R-HSA-15869 | Metabolism of nucleotides | 0.890464 | 0.050 |
| R-HSA-9609646 | HCMV Infection | 0.903042 | 0.044 |
| R-HSA-5688426 | Deubiquitination | 0.907177 | 0.042 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.911792 | 0.040 |
| R-HSA-416476 | G alpha (q) signalling events | 0.914184 | 0.039 |
| R-HSA-449147 | Signaling by Interleukins | 0.918134 | 0.037 |
| R-HSA-109582 | Hemostasis | 0.918215 | 0.037 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.921355 | 0.036 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.926018 | 0.033 |
| R-HSA-9658195 | Leishmania infection | 0.926018 | 0.033 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.928727 | 0.032 |
| R-HSA-199991 | Membrane Trafficking | 0.929150 | 0.032 |
| R-HSA-212436 | Generic Transcription Pathway | 0.930517 | 0.031 |
| R-HSA-74160 | Gene expression (Transcription) | 0.930526 | 0.031 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.961628 | 0.017 |
| R-HSA-73894 | DNA Repair | 0.962953 | 0.016 |
| R-HSA-392499 | Metabolism of proteins | 0.964985 | 0.015 |
| R-HSA-418594 | G alpha (i) signalling events | 0.975706 | 0.011 |
| R-HSA-168249 | Innate Immune System | 0.977824 | 0.010 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.978712 | 0.009 |
| R-HSA-388396 | GPCR downstream signalling | 0.992455 | 0.003 |
| R-HSA-9679506 | SARS-CoV Infections | 0.993439 | 0.003 |
| R-HSA-168256 | Immune System | 0.993592 | 0.003 |
| R-HSA-1643685 | Disease | 0.995315 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996092 | 0.002 |
| R-HSA-9824446 | Viral Infection Pathways | 0.997515 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999853 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999972 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
SRPK1 |
0.884 | 0.460 | -3 | 0.885 |
CLK3 |
0.881 | 0.378 | 1 | 0.911 |
CDKL1 |
0.881 | 0.441 | -3 | 0.907 |
CDKL5 |
0.880 | 0.410 | -3 | 0.910 |
PIM3 |
0.879 | 0.367 | -3 | 0.894 |
HIPK4 |
0.878 | 0.391 | 1 | 0.898 |
COT |
0.877 | 0.107 | 2 | 0.852 |
NUAK2 |
0.876 | 0.361 | -3 | 0.904 |
PRKD2 |
0.876 | 0.383 | -3 | 0.892 |
SRPK2 |
0.876 | 0.439 | -3 | 0.850 |
RSK2 |
0.876 | 0.395 | -3 | 0.898 |
PRKD1 |
0.874 | 0.313 | -3 | 0.901 |
PIM1 |
0.874 | 0.416 | -3 | 0.886 |
NLK |
0.873 | 0.279 | 1 | 0.908 |
NDR2 |
0.873 | 0.249 | -3 | 0.871 |
RSK3 |
0.873 | 0.376 | -3 | 0.898 |
P90RSK |
0.872 | 0.378 | -3 | 0.903 |
CAMK1B |
0.872 | 0.314 | -3 | 0.905 |
PKN3 |
0.870 | 0.280 | -3 | 0.902 |
ICK |
0.869 | 0.379 | -3 | 0.916 |
AMPKA1 |
0.869 | 0.314 | -3 | 0.892 |
NDR1 |
0.868 | 0.274 | -3 | 0.886 |
CDC7 |
0.868 | 0.052 | 1 | 0.826 |
WNK1 |
0.868 | 0.227 | -2 | 0.933 |
DYRK2 |
0.867 | 0.374 | 1 | 0.832 |
CLK1 |
0.867 | 0.438 | -3 | 0.878 |
TSSK1 |
0.867 | 0.309 | -3 | 0.899 |
P70S6KB |
0.866 | 0.332 | -3 | 0.895 |
AMPKA2 |
0.866 | 0.333 | -3 | 0.886 |
CLK4 |
0.866 | 0.417 | -3 | 0.886 |
SKMLCK |
0.866 | 0.273 | -2 | 0.909 |
HIPK1 |
0.866 | 0.450 | 1 | 0.850 |
PRPK |
0.866 | -0.039 | -1 | 0.873 |
NUAK1 |
0.866 | 0.313 | -3 | 0.888 |
SRPK3 |
0.865 | 0.375 | -3 | 0.863 |
MARK4 |
0.865 | 0.184 | 4 | 0.906 |
MOS |
0.864 | 0.059 | 1 | 0.880 |
PRKD3 |
0.864 | 0.368 | -3 | 0.881 |
DAPK2 |
0.864 | 0.322 | -3 | 0.900 |
MTOR |
0.864 | 0.006 | 1 | 0.829 |
HIPK2 |
0.864 | 0.401 | 1 | 0.766 |
MAPKAPK3 |
0.864 | 0.285 | -3 | 0.883 |
AURC |
0.864 | 0.246 | -2 | 0.693 |
MST4 |
0.864 | 0.196 | 2 | 0.875 |
PKACG |
0.864 | 0.271 | -2 | 0.792 |
PKCD |
0.864 | 0.263 | 2 | 0.797 |
CLK2 |
0.863 | 0.442 | -3 | 0.878 |
CAMLCK |
0.863 | 0.267 | -2 | 0.893 |
PKN2 |
0.862 | 0.234 | -3 | 0.877 |
MELK |
0.862 | 0.314 | -3 | 0.885 |
NIK |
0.862 | 0.252 | -3 | 0.878 |
MAPKAPK2 |
0.862 | 0.314 | -3 | 0.865 |
DYRK1A |
0.861 | 0.420 | 1 | 0.858 |
ULK2 |
0.861 | -0.058 | 2 | 0.776 |
RSK4 |
0.861 | 0.366 | -3 | 0.876 |
MSK2 |
0.860 | 0.315 | -3 | 0.879 |
ERK5 |
0.860 | 0.103 | 1 | 0.865 |
TSSK2 |
0.860 | 0.217 | -5 | 0.829 |
AKT2 |
0.860 | 0.405 | -3 | 0.855 |
GCN2 |
0.860 | -0.138 | 2 | 0.784 |
DSTYK |
0.860 | -0.034 | 2 | 0.870 |
LATS2 |
0.859 | 0.161 | -5 | 0.696 |
PIM2 |
0.858 | 0.396 | -3 | 0.883 |
RAF1 |
0.858 | -0.061 | 1 | 0.809 |
NIM1 |
0.858 | 0.165 | 3 | 0.784 |
NEK6 |
0.858 | 0.009 | -2 | 0.907 |
SIK |
0.858 | 0.301 | -3 | 0.864 |
ATR |
0.858 | 0.029 | 1 | 0.857 |
QSK |
0.858 | 0.258 | 4 | 0.881 |
CAMK2D |
0.857 | 0.162 | -3 | 0.892 |
HIPK3 |
0.857 | 0.407 | 1 | 0.831 |
PKACB |
0.857 | 0.320 | -2 | 0.713 |
PDHK4 |
0.857 | -0.209 | 1 | 0.848 |
PKCB |
0.857 | 0.254 | 2 | 0.753 |
BRSK1 |
0.856 | 0.262 | -3 | 0.886 |
BMPR2 |
0.856 | -0.148 | -2 | 0.921 |
MNK2 |
0.856 | 0.195 | -2 | 0.840 |
CDK7 |
0.856 | 0.215 | 1 | 0.811 |
WNK3 |
0.856 | 0.021 | 1 | 0.822 |
SGK3 |
0.856 | 0.353 | -3 | 0.870 |
DYRK1B |
0.856 | 0.377 | 1 | 0.793 |
DYRK3 |
0.856 | 0.423 | 1 | 0.847 |
CAMK2G |
0.855 | -0.068 | 2 | 0.797 |
NEK7 |
0.855 | -0.071 | -3 | 0.796 |
QIK |
0.855 | 0.199 | -3 | 0.873 |
HUNK |
0.855 | -0.011 | 2 | 0.765 |
IKKB |
0.855 | -0.107 | -2 | 0.807 |
CDK5 |
0.854 | 0.243 | 1 | 0.835 |
RIPK3 |
0.854 | 0.001 | 3 | 0.755 |
PAK1 |
0.854 | 0.191 | -2 | 0.816 |
PRKX |
0.854 | 0.352 | -3 | 0.813 |
AURB |
0.854 | 0.216 | -2 | 0.692 |
TGFBR2 |
0.853 | 0.002 | -2 | 0.826 |
CDK8 |
0.853 | 0.164 | 1 | 0.801 |
BRSK2 |
0.853 | 0.204 | -3 | 0.882 |
MSK1 |
0.853 | 0.304 | -3 | 0.876 |
PKG2 |
0.853 | 0.254 | -2 | 0.714 |
PKCA |
0.853 | 0.206 | 2 | 0.748 |
PKCG |
0.852 | 0.200 | 2 | 0.753 |
KIS |
0.852 | 0.148 | 1 | 0.816 |
TBK1 |
0.852 | -0.140 | 1 | 0.688 |
PKCZ |
0.852 | 0.192 | 2 | 0.776 |
CAMK1G |
0.852 | 0.299 | -3 | 0.890 |
PAK3 |
0.852 | 0.153 | -2 | 0.817 |
MLK1 |
0.851 | -0.053 | 2 | 0.826 |
PDHK1 |
0.851 | -0.185 | 1 | 0.818 |
CAMK4 |
0.851 | 0.151 | -3 | 0.875 |
IRE1 |
0.851 | 0.067 | 1 | 0.827 |
RIPK1 |
0.851 | 0.041 | 1 | 0.826 |
CDK18 |
0.851 | 0.230 | 1 | 0.758 |
DYRK4 |
0.851 | 0.333 | 1 | 0.770 |
NEK9 |
0.850 | -0.040 | 2 | 0.829 |
CHAK2 |
0.850 | -0.008 | -1 | 0.873 |
MYLK4 |
0.849 | 0.249 | -2 | 0.814 |
DCAMKL1 |
0.849 | 0.322 | -3 | 0.877 |
PKR |
0.849 | 0.179 | 1 | 0.858 |
CAMK2B |
0.849 | 0.169 | 2 | 0.775 |
MNK1 |
0.849 | 0.190 | -2 | 0.851 |
PHKG1 |
0.849 | 0.181 | -3 | 0.883 |
CDK19 |
0.849 | 0.169 | 1 | 0.768 |
ULK1 |
0.849 | -0.139 | -3 | 0.778 |
PKCH |
0.849 | 0.197 | 2 | 0.738 |
CDK13 |
0.848 | 0.188 | 1 | 0.787 |
AKT1 |
0.848 | 0.367 | -3 | 0.858 |
CAMK2A |
0.848 | 0.191 | 2 | 0.776 |
LATS1 |
0.847 | 0.183 | -3 | 0.867 |
P38A |
0.847 | 0.212 | 1 | 0.829 |
MLK2 |
0.847 | -0.028 | 2 | 0.816 |
FAM20C |
0.847 | 0.106 | 2 | 0.651 |
MARK3 |
0.847 | 0.160 | 4 | 0.844 |
MASTL |
0.847 | -0.124 | -2 | 0.878 |
IKKE |
0.847 | -0.181 | 1 | 0.676 |
CDK10 |
0.846 | 0.308 | 1 | 0.780 |
MARK2 |
0.846 | 0.153 | 4 | 0.819 |
CDK1 |
0.846 | 0.204 | 1 | 0.770 |
CDK9 |
0.846 | 0.202 | 1 | 0.791 |
GRK1 |
0.845 | 0.019 | -2 | 0.851 |
JNK2 |
0.845 | 0.227 | 1 | 0.745 |
MAK |
0.845 | 0.429 | -2 | 0.741 |
ANKRD3 |
0.845 | -0.039 | 1 | 0.851 |
MAPKAPK5 |
0.845 | 0.230 | -3 | 0.875 |
CDK12 |
0.845 | 0.209 | 1 | 0.758 |
MOK |
0.845 | 0.470 | 1 | 0.857 |
CAMK1D |
0.844 | 0.348 | -3 | 0.848 |
PAK6 |
0.844 | 0.138 | -2 | 0.743 |
PKACA |
0.844 | 0.307 | -2 | 0.657 |
CHK1 |
0.844 | 0.157 | -3 | 0.868 |
BCKDK |
0.844 | -0.136 | -1 | 0.814 |
P70S6K |
0.844 | 0.308 | -3 | 0.863 |
PKCT |
0.843 | 0.243 | 2 | 0.747 |
MLK3 |
0.843 | 0.000 | 2 | 0.765 |
PAK2 |
0.843 | 0.131 | -2 | 0.807 |
IRE2 |
0.843 | 0.032 | 2 | 0.756 |
WNK4 |
0.843 | 0.198 | -2 | 0.932 |
CDK17 |
0.843 | 0.204 | 1 | 0.705 |
CDK14 |
0.843 | 0.260 | 1 | 0.789 |
AKT3 |
0.842 | 0.399 | -3 | 0.819 |
SSTK |
0.842 | 0.211 | 4 | 0.886 |
ATM |
0.842 | 0.014 | 1 | 0.791 |
SGK1 |
0.842 | 0.415 | -3 | 0.805 |
GRK5 |
0.842 | -0.206 | -3 | 0.767 |
JNK3 |
0.842 | 0.195 | 1 | 0.784 |
IKKA |
0.842 | -0.090 | -2 | 0.792 |
MARK1 |
0.841 | 0.140 | 4 | 0.869 |
NEK2 |
0.841 | -0.013 | 2 | 0.803 |
ERK1 |
0.840 | 0.186 | 1 | 0.753 |
SNRK |
0.840 | 0.047 | 2 | 0.684 |
VRK2 |
0.840 | 0.027 | 1 | 0.897 |
SMMLCK |
0.839 | 0.265 | -3 | 0.900 |
DLK |
0.839 | -0.143 | 1 | 0.822 |
P38G |
0.839 | 0.205 | 1 | 0.694 |
ERK2 |
0.839 | 0.170 | 1 | 0.798 |
CDK3 |
0.839 | 0.222 | 1 | 0.723 |
CDK2 |
0.838 | 0.139 | 1 | 0.835 |
P38B |
0.838 | 0.188 | 1 | 0.758 |
GRK6 |
0.838 | -0.112 | 1 | 0.819 |
AURA |
0.837 | 0.133 | -2 | 0.661 |
IRAK4 |
0.837 | 0.097 | 1 | 0.820 |
DAPK3 |
0.837 | 0.321 | -3 | 0.888 |
PKCI |
0.837 | 0.186 | 2 | 0.755 |
BMPR1B |
0.836 | 0.033 | 1 | 0.771 |
PKCE |
0.836 | 0.273 | 2 | 0.739 |
DCAMKL2 |
0.836 | 0.182 | -3 | 0.890 |
PHKG2 |
0.836 | 0.184 | -3 | 0.869 |
SBK |
0.836 | 0.417 | -3 | 0.791 |
CHAK1 |
0.835 | -0.049 | 2 | 0.752 |
PKN1 |
0.835 | 0.296 | -3 | 0.873 |
TTBK2 |
0.835 | -0.179 | 2 | 0.693 |
PLK1 |
0.835 | -0.083 | -2 | 0.847 |
ALK4 |
0.835 | -0.063 | -2 | 0.858 |
PRP4 |
0.835 | 0.103 | -3 | 0.710 |
CHK2 |
0.834 | 0.358 | -3 | 0.822 |
DNAPK |
0.834 | 0.036 | 1 | 0.713 |
MEK1 |
0.833 | -0.147 | 2 | 0.821 |
CDK16 |
0.833 | 0.208 | 1 | 0.725 |
CAMK1A |
0.833 | 0.340 | -3 | 0.827 |
TGFBR1 |
0.833 | -0.043 | -2 | 0.826 |
SMG1 |
0.833 | -0.041 | 1 | 0.813 |
MRCKB |
0.833 | 0.344 | -3 | 0.862 |
DRAK1 |
0.832 | 0.009 | 1 | 0.756 |
MLK4 |
0.832 | -0.075 | 2 | 0.739 |
MPSK1 |
0.832 | 0.137 | 1 | 0.864 |
NEK5 |
0.831 | 0.019 | 1 | 0.844 |
GRK7 |
0.831 | 0.007 | 1 | 0.781 |
PERK |
0.830 | -0.079 | -2 | 0.879 |
YSK4 |
0.830 | -0.145 | 1 | 0.745 |
ROCK2 |
0.829 | 0.348 | -3 | 0.873 |
MRCKA |
0.829 | 0.316 | -3 | 0.867 |
MST3 |
0.829 | 0.094 | 2 | 0.834 |
DAPK1 |
0.829 | 0.287 | -3 | 0.884 |
GRK4 |
0.829 | -0.223 | -2 | 0.877 |
ALK2 |
0.828 | -0.040 | -2 | 0.840 |
HRI |
0.828 | -0.113 | -2 | 0.883 |
PINK1 |
0.828 | -0.080 | 1 | 0.911 |
CDK4 |
0.827 | 0.228 | 1 | 0.751 |
PLK4 |
0.826 | -0.076 | 2 | 0.625 |
PASK |
0.826 | 0.143 | -3 | 0.888 |
DMPK1 |
0.826 | 0.373 | -3 | 0.871 |
BRAF |
0.826 | -0.082 | -4 | 0.762 |
MEK5 |
0.826 | -0.133 | 2 | 0.815 |
GAK |
0.826 | 0.163 | 1 | 0.900 |
P38D |
0.825 | 0.184 | 1 | 0.720 |
MEKK1 |
0.825 | -0.110 | 1 | 0.803 |
TLK2 |
0.825 | -0.113 | 1 | 0.802 |
ERK7 |
0.825 | 0.068 | 2 | 0.548 |
PLK3 |
0.825 | -0.129 | 2 | 0.745 |
CDK6 |
0.824 | 0.194 | 1 | 0.776 |
PAK5 |
0.824 | 0.117 | -2 | 0.681 |
TAO3 |
0.824 | 0.027 | 1 | 0.789 |
ACVR2A |
0.823 | -0.094 | -2 | 0.811 |
MEKK2 |
0.823 | -0.078 | 2 | 0.800 |
CRIK |
0.822 | 0.373 | -3 | 0.864 |
ZAK |
0.822 | -0.124 | 1 | 0.768 |
PAK4 |
0.821 | 0.116 | -2 | 0.681 |
ACVR2B |
0.821 | -0.113 | -2 | 0.827 |
PDK1 |
0.821 | 0.110 | 1 | 0.801 |
NEK8 |
0.821 | -0.041 | 2 | 0.813 |
LKB1 |
0.820 | -0.011 | -3 | 0.808 |
PKG1 |
0.819 | 0.238 | -2 | 0.628 |
TAO2 |
0.819 | 0.005 | 2 | 0.841 |
ROCK1 |
0.818 | 0.330 | -3 | 0.865 |
MEKK3 |
0.818 | -0.196 | 1 | 0.784 |
BUB1 |
0.818 | 0.153 | -5 | 0.768 |
BMPR1A |
0.818 | -0.015 | 1 | 0.751 |
LRRK2 |
0.817 | 0.074 | 2 | 0.832 |
GRK2 |
0.817 | -0.116 | -2 | 0.752 |
CAMKK1 |
0.817 | -0.121 | -2 | 0.822 |
GSK3A |
0.817 | 0.051 | 4 | 0.470 |
PBK |
0.817 | 0.185 | 1 | 0.837 |
IRAK1 |
0.816 | -0.151 | -1 | 0.795 |
CK1E |
0.816 | -0.073 | -3 | 0.457 |
GSK3B |
0.815 | -0.000 | 4 | 0.460 |
MEKK6 |
0.815 | 0.013 | 1 | 0.798 |
NEK11 |
0.815 | -0.129 | 1 | 0.770 |
CAMKK2 |
0.814 | -0.081 | -2 | 0.817 |
TLK1 |
0.814 | -0.181 | -2 | 0.856 |
NEK4 |
0.813 | -0.066 | 1 | 0.773 |
LOK |
0.813 | 0.054 | -2 | 0.833 |
JNK1 |
0.813 | 0.132 | 1 | 0.744 |
TNIK |
0.813 | 0.061 | 3 | 0.850 |
NEK1 |
0.812 | -0.001 | 1 | 0.808 |
VRK1 |
0.812 | 0.003 | 2 | 0.816 |
HGK |
0.811 | -0.003 | 3 | 0.860 |
GCK |
0.811 | -0.014 | 1 | 0.764 |
MAP3K15 |
0.811 | -0.038 | 1 | 0.761 |
MINK |
0.809 | -0.029 | 1 | 0.753 |
EEF2K |
0.808 | -0.044 | 3 | 0.828 |
STK33 |
0.807 | -0.085 | 2 | 0.607 |
HPK1 |
0.807 | 0.006 | 1 | 0.733 |
TTBK1 |
0.807 | -0.208 | 2 | 0.610 |
TAK1 |
0.807 | -0.088 | 1 | 0.810 |
CK1D |
0.807 | -0.081 | -3 | 0.402 |
KHS2 |
0.806 | 0.080 | 1 | 0.749 |
KHS1 |
0.806 | 0.052 | 1 | 0.734 |
HASPIN |
0.806 | 0.117 | -1 | 0.757 |
NEK3 |
0.805 | -0.013 | 1 | 0.763 |
YSK1 |
0.805 | 0.012 | 2 | 0.813 |
MST2 |
0.804 | -0.151 | 1 | 0.766 |
CK1A2 |
0.803 | -0.091 | -3 | 0.412 |
CK1G1 |
0.802 | -0.131 | -3 | 0.432 |
SLK |
0.801 | -0.055 | -2 | 0.778 |
GRK3 |
0.801 | -0.118 | -2 | 0.709 |
MEK2 |
0.800 | -0.199 | 2 | 0.799 |
BIKE |
0.800 | 0.135 | 1 | 0.806 |
RIPK2 |
0.799 | -0.191 | 1 | 0.708 |
MST1 |
0.797 | -0.139 | 1 | 0.752 |
PDHK3_TYR |
0.795 | 0.145 | 4 | 0.940 |
PLK2 |
0.795 | -0.105 | -3 | 0.720 |
CK2A2 |
0.794 | -0.069 | 1 | 0.687 |
MYO3B |
0.794 | 0.031 | 2 | 0.824 |
TTK |
0.794 | -0.010 | -2 | 0.856 |
LIMK2_TYR |
0.791 | 0.193 | -3 | 0.859 |
PKMYT1_TYR |
0.790 | 0.141 | 3 | 0.856 |
TAO1 |
0.789 | -0.018 | 1 | 0.706 |
TESK1_TYR |
0.789 | 0.041 | 3 | 0.878 |
OSR1 |
0.788 | -0.088 | 2 | 0.797 |
AAK1 |
0.786 | 0.170 | 1 | 0.720 |
MAP2K4_TYR |
0.785 | -0.007 | -1 | 0.878 |
PINK1_TYR |
0.785 | 0.025 | 1 | 0.863 |
CK2A1 |
0.784 | -0.083 | 1 | 0.662 |
ASK1 |
0.784 | -0.143 | 1 | 0.746 |
MAP2K7_TYR |
0.783 | -0.114 | 2 | 0.838 |
PDHK4_TYR |
0.783 | -0.040 | 2 | 0.854 |
MYO3A |
0.783 | -0.069 | 1 | 0.763 |
LIMK1_TYR |
0.782 | 0.023 | 2 | 0.837 |
YANK3 |
0.782 | -0.064 | 2 | 0.395 |
MAP2K6_TYR |
0.781 | -0.064 | -1 | 0.872 |
DDR1 |
0.779 | 0.030 | 4 | 0.904 |
BMPR2_TYR |
0.778 | -0.080 | -1 | 0.856 |
RET |
0.777 | -0.037 | 1 | 0.811 |
EPHA6 |
0.777 | 0.013 | -1 | 0.859 |
ALPHAK3 |
0.776 | -0.136 | -1 | 0.767 |
PDHK1_TYR |
0.775 | -0.169 | -1 | 0.884 |
TYRO3 |
0.775 | -0.062 | 3 | 0.828 |
MST1R |
0.775 | -0.059 | 3 | 0.825 |
ROS1 |
0.774 | -0.042 | 3 | 0.806 |
TYK2 |
0.774 | -0.117 | 1 | 0.801 |
TNK2 |
0.774 | 0.071 | 3 | 0.795 |
YES1 |
0.773 | 0.007 | -1 | 0.881 |
EPHB4 |
0.771 | -0.051 | -1 | 0.851 |
TNK1 |
0.771 | 0.057 | 3 | 0.795 |
JAK2 |
0.770 | -0.134 | 1 | 0.800 |
CSF1R |
0.769 | -0.097 | 3 | 0.813 |
ABL2 |
0.768 | -0.037 | -1 | 0.829 |
FGR |
0.768 | -0.065 | 1 | 0.856 |
TNNI3K_TYR |
0.767 | 0.036 | 1 | 0.810 |
TXK |
0.767 | 0.010 | 1 | 0.813 |
DDR2 |
0.767 | 0.127 | 3 | 0.781 |
JAK3 |
0.766 | -0.115 | 1 | 0.798 |
HCK |
0.765 | -0.063 | -1 | 0.850 |
FER |
0.765 | -0.143 | 1 | 0.853 |
NEK10_TYR |
0.765 | -0.033 | 1 | 0.685 |
INSRR |
0.764 | -0.098 | 3 | 0.777 |
PDGFRB |
0.764 | -0.106 | 3 | 0.834 |
LCK |
0.764 | 0.004 | -1 | 0.849 |
STLK3 |
0.764 | -0.251 | 1 | 0.721 |
ABL1 |
0.764 | -0.063 | -1 | 0.827 |
BLK |
0.763 | 0.032 | -1 | 0.859 |
AXL |
0.763 | -0.061 | 3 | 0.802 |
CK1A |
0.762 | -0.133 | -3 | 0.308 |
TEK |
0.762 | -0.109 | 3 | 0.776 |
JAK1 |
0.762 | -0.053 | 1 | 0.729 |
FGFR2 |
0.761 | -0.127 | 3 | 0.811 |
ITK |
0.761 | -0.078 | -1 | 0.823 |
SRMS |
0.761 | -0.106 | 1 | 0.816 |
WEE1_TYR |
0.761 | -0.037 | -1 | 0.770 |
EPHB3 |
0.760 | -0.093 | -1 | 0.841 |
KDR |
0.760 | -0.088 | 3 | 0.772 |
FLT3 |
0.760 | -0.133 | 3 | 0.815 |
MERTK |
0.759 | -0.074 | 3 | 0.785 |
ALK |
0.759 | -0.056 | 3 | 0.772 |
FGFR1 |
0.759 | -0.122 | 3 | 0.800 |
EPHA4 |
0.759 | -0.118 | 2 | 0.740 |
LTK |
0.758 | -0.053 | 3 | 0.782 |
EPHB1 |
0.758 | -0.136 | 1 | 0.802 |
KIT |
0.758 | -0.156 | 3 | 0.820 |
PDGFRA |
0.758 | -0.164 | 3 | 0.832 |
EPHB2 |
0.757 | -0.108 | -1 | 0.830 |
TEC |
0.756 | -0.075 | -1 | 0.788 |
BTK |
0.755 | -0.160 | -1 | 0.793 |
EPHA1 |
0.755 | -0.054 | 3 | 0.785 |
FYN |
0.753 | -0.023 | -1 | 0.826 |
BMX |
0.753 | -0.084 | -1 | 0.743 |
PTK6 |
0.753 | -0.178 | -1 | 0.762 |
MET |
0.752 | -0.139 | 3 | 0.805 |
EPHA7 |
0.752 | -0.093 | 2 | 0.743 |
PTK2B |
0.750 | -0.039 | -1 | 0.832 |
LYN |
0.748 | -0.101 | 3 | 0.740 |
FRK |
0.747 | -0.127 | -1 | 0.856 |
EPHA3 |
0.747 | -0.174 | 2 | 0.719 |
FGFR3 |
0.747 | -0.183 | 3 | 0.782 |
INSR |
0.746 | -0.177 | 3 | 0.749 |
ERBB2 |
0.746 | -0.213 | 1 | 0.764 |
NTRK1 |
0.745 | -0.260 | -1 | 0.811 |
SRC |
0.745 | -0.070 | -1 | 0.838 |
FLT4 |
0.744 | -0.214 | 3 | 0.764 |
NTRK2 |
0.744 | -0.241 | 3 | 0.776 |
FLT1 |
0.744 | -0.210 | -1 | 0.804 |
MATK |
0.743 | -0.141 | -1 | 0.748 |
EPHA5 |
0.742 | -0.122 | 2 | 0.728 |
YANK2 |
0.742 | -0.127 | 2 | 0.414 |
CK1G3 |
0.741 | -0.148 | -3 | 0.259 |
EPHA8 |
0.741 | -0.121 | -1 | 0.817 |
NTRK3 |
0.739 | -0.204 | -1 | 0.762 |
CSK |
0.737 | -0.187 | 2 | 0.747 |
EGFR |
0.735 | -0.152 | 1 | 0.677 |
PTK2 |
0.733 | -0.092 | -1 | 0.752 |
MUSK |
0.731 | -0.159 | 1 | 0.671 |
FGFR4 |
0.731 | -0.180 | -1 | 0.768 |
IGF1R |
0.729 | -0.196 | 3 | 0.693 |
EPHA2 |
0.727 | -0.158 | -1 | 0.760 |
SYK |
0.725 | -0.136 | -1 | 0.738 |
ERBB4 |
0.719 | -0.143 | 1 | 0.674 |
FES |
0.717 | -0.169 | -1 | 0.728 |
CK1G2 |
0.714 | -0.163 | -3 | 0.352 |
ZAP70 |
0.705 | -0.130 | -1 | 0.670 |