Motif 633 (n=273)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2194 | ochoa | Snf2 related CREBBP activator protein | None |
| A6H8Y1 | BDP1 | S423 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NCL7 | ANKRD33B | S44 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| A6NKT7 | RGPD3 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S168 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00192 | ARVCF | S606 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00193 | SMAP | S90 | ochoa | Small acidic protein | None |
| O00562 | PITPNM1 | S373 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O14545 | TRAFD1 | S280 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14646 | CHD1 | Y1068 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14715 | RGPD8 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14978 | ZNF263 | S155 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
| O15062 | ZBTB5 | S378 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15067 | PFAS | S540 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15085 | ARHGEF11 | S1135 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15355 | PPM1G | S201 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15534 | PER1 | S1031 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43567 | RNF13 | S319 | ochoa | E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) | E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786). {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:30595371}. |
| O43581 | SYT7 | S105 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O43815 | STRN | S259 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43829 | ZBTB14 | S233 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O60293 | ZFC3H1 | S271 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O75152 | ZC3H11A | S576 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75153 | CLUH | S649 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75264 | SMIM24 | Y76 | ochoa | Small integral membrane protein 24 | None |
| O75688 | PPM1B | S376 | ochoa | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O75781 | PALM | S189 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O75995 | SASH3 | S117 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94915 | FRYL | S479 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95235 | KIF20A | S632 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95239 | KIF4A | S507 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95613 | PCNT | S2878 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95696 | BRD1 | S131 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95810 | CAVIN2 | S177 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P02671 | FGA | S551 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P05181 | CYP2E1 | S256 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P05787 | KRT8 | S291 | psp | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P06213 | INSR | S1033 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P08069 | IGF1R | S1009 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08151 | GLI1 | S204 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P09017 | HOXC4 | S33 | ochoa | Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P09629 | HOXB7 | S133 | psp | Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P0DJD0 | RGPD1 | S1465 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1473 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMV8 | HSPA1A | Y525 | psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DPH7 | TUBA3C | Y272 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y272 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10244 | MYBL2 | S20 | ochoa|psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P10515 | DLAT | S475 | ochoa | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). {ECO:0000305|PubMed:20160912}. |
| P10636 | MAPT | S318 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10645 | CHGA | S113 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P10809 | HSPD1 | S398 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P13569 | CFTR | S707 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P15923 | TCF3 | S529 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P18583 | SON | S163 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18583 | SON | S353 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19634 | SLC9A1 | S599 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20810 | CAST | S71 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P22314 | UBA1 | S810 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P22732 | SLC2A5 | S482 | ochoa | Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5) | Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}. |
| P28290 | ITPRID2 | S410 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P33981 | TTK | S393 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | S1122 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1808 | ochoa|psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S23 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S1642 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42858 | HTT | S459 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46821 | MAP1B | S2126 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S1506 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48788 | TNNI2 | S59 | ochoa | Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P49006 | MARCKSL1 | S135 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49023 | PXN | S126 | ochoa|psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49792 | RANBP2 | S2456 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51531 | SMARCA2 | S670 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51858 | HDGF | S132 | ochoa|psp | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P51957 | NEK4 | S662 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52756 | RBM5 | Y620 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P52943 | CRIP2 | S104 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P53007 | SLC25A1 | S156 | ochoa | Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) | Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:29031613, PubMed:29238895, PubMed:39881208). {ECO:0000269|PubMed:26870663, ECO:0000269|PubMed:29031613, ECO:0000269|PubMed:29238895, ECO:0000269|PubMed:39881208}. |
| P54132 | BLM | S580 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P56182 | RRP1 | S291 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P68363 | TUBA1B | Y272 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y272 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78536 | ADAM17 | S786 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| P78559 | MAP1A | S1029 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00534 | CDK6 | S223 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q02447 | SP3 | S566 | ochoa|psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q02952 | AKAP12 | S554 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S644 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S772 | psp | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1755 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q12774 | ARHGEF5 | S199 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12873 | CHD3 | S1819 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12906 | ILF3 | S362 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12912 | IRAG2 | S444 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13144 | EIF2B5 | S469 | psp | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13263 | TRIM28 | S258 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13425 | SNTB2 | S211 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q13428 | TCOF1 | S1383 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13488 | TCIRG1 | S685 | ochoa | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation (PubMed:10329006). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:10329006}. |
| Q13563 | PKD2 | S795 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14156 | EFR3A | S222 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14157 | UBAP2L | S254 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14162 | SCARF1 | S684 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14566 | MCM6 | S718 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14596 | NBR1 | S622 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14643 | ITPR1 | S421 | psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q14694 | USP10 | S549 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14865 | ARID5B | S468 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q14C86 | GAPVD1 | S1012 | psp | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
| Q15084 | PDIA6 | S259 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15185 | PTGES3 | S34 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15545 | TAF7 | S200 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q15637 | SF1 | S89 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q17R98 | ZNF827 | S157 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q1KMD3 | HNRNPUL2 | S168 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q3KR16 | PLEKHG6 | S537 | ochoa | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
| Q4LE39 | ARID4B | S896 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4VC44 | FLYWCH1 | S696 | ochoa | FLYWCH-type zinc finger-containing protein 1 | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}. |
| Q52LA3 | LIN52 | S53 | ochoa | Protein lin-52 homolog | None |
| Q53GS9 | USP39 | S65 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q5H9R7 | PPP6R3 | S300 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5H9R7 | PPP6R3 | S823 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JSL3 | DOCK11 | S296 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5TBA9 | FRY | S2419 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5TH69 | ARFGEF3 | S471 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT06 | CEP350 | S2206 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VZK9 | CARMIL1 | S960 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63HN8 | RNF213 | S69 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q68E01 | INTS3 | S522 | ochoa | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Q6GQQ9 | OTUD7B | S475 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6P0N0 | MIS18BP1 | S991 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PEY2 | TUBA3E | Y272 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PJF5 | RHBDF2 | S115 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6UXK2 | ISLR2 | S650 | ochoa | Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein) | Required for axon extension during neural development. {ECO:0000250}. |
| Q6VMQ6 | ATF7IP | S403 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6WCQ1 | MPRIP | S662 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6WKZ4 | RAB11FIP1 | S500 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6Y2X3 | DNAJC14 | S187 | ochoa | DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) | Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}. |
| Q6ZRS2 | SRCAP | S2371 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZUM4 | ARHGAP27 | S625 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71F23 | CENPU | S96 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71U36 | TUBA1A | Y272 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z3D4 | LYSMD3 | S53 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q7Z3J3 | RGPD4 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3T8 | ZFYVE16 | S939 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z5K2 | WAPL | S549 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6I6 | ARHGAP30 | S840 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6Z7 | HUWE1 | S3818 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TB3 | ALPK2 | S1698 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
| Q86TI0 | TBC1D1 | S556 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86X02 | CDR2L | S417 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86Y82 | STX12 | S142 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q8IY92 | SLX4 | S1172 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IY95 | TMEM192 | Y215 | ochoa | Transmembrane protein 192 | None |
| Q8IYI6 | EXOC8 | S35 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8N554 | ZNF276 | S379 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8N6N3 | C1orf52 | S65 | ochoa | UPF0690 protein C1orf52 (BCL10-associated gene protein) | None |
| Q8N6Q8 | METTL25 | S350 | ochoa | Probable methyltransferase-like protein 25 (EC 2.1.1.-) | Probable methyltransferase. {ECO:0000305}. |
| Q8N8E2 | ZNF513 | Y82 | ochoa | Zinc finger protein 513 | Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}. |
| Q8N8K9 | KIAA1958 | S82 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NAN2 | MIGA1 | S293 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NCF5 | NFATC2IP | S168 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NEB9 | PIK3C3 | S249 | ochoa|psp | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NF91 | SYNE1 | S1362 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S1098 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFZ5 | TNIP2 | S186 | ochoa | TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
| Q8TC76 | FAM110B | S301 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TF72 | SHROOM3 | S1421 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WWA1 | TMEM40 | S141 | ochoa | Transmembrane protein 40 | None |
| Q8WYP5 | AHCTF1 | S1511 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WZ73 | RFFL | S242 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92628 | KIAA0232 | S158 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92793 | CREBBP | S1382 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92854 | SEMA4D | S798 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q93009 | USP7 | S967 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96A49 | SYAP1 | S277 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
| Q96B36 | AKT1S1 | S211 | ochoa | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
| Q96CT7 | CCDC124 | S141 | ochoa | Coiled-coil domain-containing protein 124 | Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}. |
| Q96CW6 | SLC7A6OS | S258 | ochoa | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q96D71 | REPS1 | S377 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96H22 | CENPN | S226 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96I25 | RBM17 | S169 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96K31 | C8orf76 | S25 | ochoa | Uncharacterized protein C8orf76 | None |
| Q96KG9 | SCYL1 | S743 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q96PU5 | NEDD4L | S538 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96R06 | SPAG5 | S944 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96T23 | RSF1 | S977 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99538 | LGMN | S226 | psp | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1) | Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000269|PubMed:23776206, ECO:0000269|PubMed:9872320}. |
| Q99614 | TTC1 | S83 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q99661 | KIF2C | S179 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99666 | RGPD5 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQE3 | TUBA1C | Y272 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRP8 | PYM1 | S177 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
| Q9BRS8 | LARP6 | S72 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BRY0 | SLC39A3 | S114 | ochoa | Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) | Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250|UniProtKB:Q99K24}. |
| Q9BTC0 | DIDO1 | S1327 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BY44 | EIF2A | Y446 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9BY84 | DUSP16 | S627 | ochoa | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
| Q9BYE7 | PCGF6 | S232 | ochoa | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}. |
| Q9BYV8 | CEP41 | S99 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
| Q9H1J1 | UPF3A | S339 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H2P0 | ADNP | S955 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H5J8 | TAF1D | S234 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H792 | PEAK1 | S1033 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H8U3 | ZFAND3 | S109 | ochoa | AN1-type zinc finger protein 3 (Testis-expressed protein 27) | None |
| Q9H8V3 | ECT2 | S367 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9HCG8 | CWC22 | S49 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9HCS7 | XAB2 | S800 | ochoa | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Q9NPD8 | UBE2T | S172 | ochoa | Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:28437106}. |
| Q9NRW4 | DUSP22 | S58 | ochoa | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). {ECO:0000250|UniProtKB:Q99N11, ECO:0000269|PubMed:11717427, ECO:0000269|PubMed:24714587, ECO:0000269|PubMed:38225265}. |
| Q9NS56 | TOPORS | S501 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NVS9 | PNPO | S164 | ochoa | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}. |
| Q9NWQ8 | PAG1 | S201 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NX63 | CHCHD3 | S50 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NY74 | ETAA1 | S345 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZJ0 | DTL | S558 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P0L2 | MARK1 | S463 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P2E9 | RRBP1 | S583 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2N2 | ARHGAP28 | S258 | ochoa | Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBE0 | SAE1 | S185 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UDY2 | TJP2 | S415 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UEY8 | ADD3 | S592 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | S89 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHE8 | STEAP1 | S36 | ochoa | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}. |
| Q9UHR5 | SAP30BP | S104 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UIS9 | MBD1 | S557 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UJY5 | GGA1 | S185 | ochoa | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9UKV3 | ACIN1 | S749 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKY7 | CDV3 | S200 | ochoa | Protein CDV3 homolog | None |
| Q9UPV0 | CEP164 | S186 | psp | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPZ3 | HPS5 | S660 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQ35 | SRRM2 | S1258 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y3Q8 | TSC22D4 | S233 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4B5 | MTCL1 | S345 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4L1 | HYOU1 | S964 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y4W2 | LAS1L | S249 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y520 | PRRC2C | S1276 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5W7 | SNX14 | S734 | ochoa | Sorting nexin-14 | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684, PubMed:25848753). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}. |
| Q9Y657 | SPIN1 | S124 | ochoa|psp | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q9Y6J0 | CABIN1 | S1471 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P06493 | CDK1 | S208 | EPSD|PSP | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P14314 | PRKCSH | S478 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q7Z4H3 | HDDC2 | S170 | Sugiyama | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}. |
| P14649 | MYL6B | Y86 | Sugiyama | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| Q9Y490 | TLN1 | Y1893 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| O75914 | PAK3 | S246 | Sugiyama | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| P08238 | HSP90AB1 | S206 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q58FF7 | HSP90AB3P | S185 | Sugiyama | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| O14646 | CHD1 | S1017 | Sugiyama | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| Q9HB07 | MYG1 | S196 | Sugiyama | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HAS0 | C17orf75 | Y38 | Sugiyama | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
| Q02790 | FKBP4 | S224 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| P35244 | RPA3 | S44 | Sugiyama | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:17596542, PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). {ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:19010961, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279, ECO:0000303|PubMed:24332808}. |
| Q9NZV7 | ZIM2 | S155 | Sugiyama | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| P62495 | ETF1 | S295 | Sugiyama | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}. |
| Q14257 | RCN2 | S298 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| P63165 | SUMO1 | S61 | Sugiyama | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| Q03112 | MECOM | S1037 | SIGNOR | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. |
| Q9Y266 | NUDC | S60 | Sugiyama | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q14141 | SEPTIN6 | S416 | Sugiyama | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| O60664 | PLIN3 | S76 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| Q15303 | ERBB4 | Y1150 | GPS6|EPSD|Sugiyama | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q9H3D4 | TP63 | S310 | SIGNOR | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| P08174 | CD55 | S138 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q6P0Q8 | MAST2 | S811 | Sugiyama | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q9UNW1 | MINPP1 | S468 | Sugiyama | Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) | Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611). {ECO:0000269|PubMed:18413611, ECO:0000269|PubMed:33257696, ECO:0000269|PubMed:36589890}. |
| Q6XUX3 | DSTYK | S404 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| O75179 | ANKRD17 | S1159 | Sugiyama | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| Q8IWZ3 | ANKHD1 | S1131 | Sugiyama | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| O60879 | DIAPH2 | S196 | SIGNOR | Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}. |
| Q9BYT3 | STK33 | S427 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9H093 | NUAK2 | S327 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 3.462602e-09 | 8.461 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.157604e-09 | 8.501 |
| R-HSA-9833482 | PKR-mediated signaling | 2.927632e-08 | 7.533 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.009303e-07 | 6.996 |
| R-HSA-983189 | Kinesins | 1.405354e-07 | 6.852 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.166092e-07 | 6.380 |
| R-HSA-9646399 | Aggrephagy | 4.904996e-07 | 6.309 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.659387e-07 | 6.332 |
| R-HSA-68877 | Mitotic Prometaphase | 2.806960e-07 | 6.552 |
| R-HSA-3371511 | HSF1 activation | 2.356795e-07 | 6.628 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.366350e-07 | 6.473 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.519700e-07 | 6.345 |
| R-HSA-3371556 | Cellular response to heat stress | 6.065752e-07 | 6.217 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 7.838418e-07 | 6.106 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.709135e-07 | 6.113 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.041408e-06 | 5.982 |
| R-HSA-1640170 | Cell Cycle | 1.062814e-06 | 5.974 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.014167e-06 | 5.696 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.585891e-06 | 5.587 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.867497e-06 | 5.413 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.261144e-06 | 5.370 |
| R-HSA-9663891 | Selective autophagy | 4.261144e-06 | 5.370 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.511626e-06 | 5.259 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.000007e-05 | 5.000 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.057319e-05 | 4.976 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.141339e-05 | 4.943 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.200103e-05 | 4.921 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.398700e-05 | 4.854 |
| R-HSA-69275 | G2/M Transition | 1.584939e-05 | 4.800 |
| R-HSA-437239 | Recycling pathway of L1 | 1.538184e-05 | 4.813 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.771226e-05 | 4.752 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.767699e-05 | 4.753 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.739609e-05 | 4.760 |
| R-HSA-190861 | Gap junction assembly | 1.920647e-05 | 4.717 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.035504e-05 | 4.691 |
| R-HSA-68882 | Mitotic Anaphase | 2.081078e-05 | 4.682 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.188591e-05 | 4.660 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.063622e-05 | 4.514 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 3.335115e-05 | 4.477 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.515267e-05 | 4.454 |
| R-HSA-9612973 | Autophagy | 4.711731e-05 | 4.327 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 5.216040e-05 | 4.283 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.863504e-05 | 4.232 |
| R-HSA-5617833 | Cilium Assembly | 7.705180e-05 | 4.113 |
| R-HSA-1632852 | Macroautophagy | 7.871865e-05 | 4.104 |
| R-HSA-190828 | Gap junction trafficking | 8.460520e-05 | 4.073 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.192664e-04 | 3.923 |
| R-HSA-5620924 | Intraflagellar transport | 1.330968e-04 | 3.876 |
| R-HSA-68886 | M Phase | 1.531326e-04 | 3.815 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.482005e-04 | 3.829 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.866677e-04 | 3.729 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.706411e-04 | 3.568 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.900848e-04 | 3.537 |
| R-HSA-2262752 | Cellular responses to stress | 3.086627e-04 | 3.511 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.343198e-04 | 3.362 |
| R-HSA-373755 | Semaphorin interactions | 5.482419e-04 | 3.261 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.074041e-04 | 3.217 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.271684e-04 | 3.203 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.554342e-04 | 3.068 |
| R-HSA-381070 | IRE1alpha activates chaperones | 9.270558e-04 | 3.033 |
| R-HSA-1538133 | G0 and Early G1 | 9.728578e-04 | 3.012 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.149800e-03 | 2.939 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.193273e-03 | 2.923 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.332309e-03 | 2.875 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.377658e-03 | 2.861 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.401936e-03 | 2.853 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.557163e-03 | 2.808 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.672960e-03 | 2.777 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.446121e-03 | 2.612 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.413478e-03 | 2.617 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.721170e-03 | 2.565 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.903003e-03 | 2.537 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.903003e-03 | 2.537 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.014765e-03 | 2.521 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.547369e-03 | 2.450 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.362902e-03 | 2.473 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.413106e-03 | 2.467 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.711207e-03 | 2.430 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.761244e-03 | 2.425 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.867721e-03 | 2.413 |
| R-HSA-391251 | Protein folding | 4.181379e-03 | 2.379 |
| R-HSA-373760 | L1CAM interactions | 4.333405e-03 | 2.363 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 5.463668e-03 | 2.263 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.457972e-03 | 2.263 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.520708e-03 | 2.258 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.673392e-03 | 2.246 |
| R-HSA-380287 | Centrosome maturation | 6.120505e-03 | 2.213 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 6.335291e-03 | 2.198 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.355477e-03 | 2.197 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 8.314957e-03 | 2.080 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 8.314957e-03 | 2.080 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 8.314957e-03 | 2.080 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.841782e-03 | 2.007 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.084860e-02 | 1.965 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.084860e-02 | 1.965 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 1.087886e-02 | 1.963 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.087886e-02 | 1.963 |
| R-HSA-8939211 | ESR-mediated signaling | 1.289550e-02 | 1.890 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.368101e-02 | 1.864 |
| R-HSA-913531 | Interferon Signaling | 1.374335e-02 | 1.862 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.596077e-02 | 1.797 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.657216e-02 | 1.781 |
| R-HSA-73886 | Chromosome Maintenance | 1.748368e-02 | 1.757 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.980003e-02 | 1.703 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.326770e-02 | 1.633 |
| R-HSA-774815 | Nucleosome assembly | 2.068377e-02 | 1.684 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.068377e-02 | 1.684 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.097137e-02 | 1.678 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.301069e-02 | 1.638 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.250241e-02 | 1.648 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.135537e-02 | 1.670 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.156548e-02 | 1.666 |
| R-HSA-199991 | Membrane Trafficking | 2.251812e-02 | 1.647 |
| R-HSA-9620244 | Long-term potentiation | 2.323498e-02 | 1.634 |
| R-HSA-9609690 | HCMV Early Events | 2.628277e-02 | 1.580 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.725498e-02 | 1.565 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.725498e-02 | 1.565 |
| R-HSA-422475 | Axon guidance | 2.972259e-02 | 1.527 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 3.500732e-02 | 1.456 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 3.500732e-02 | 1.456 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.162137e-02 | 1.500 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.162137e-02 | 1.500 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.162137e-02 | 1.500 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 3.500732e-02 | 1.456 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.120013e-02 | 1.506 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.393361e-02 | 1.469 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.162137e-02 | 1.500 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.224795e-02 | 1.491 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.393361e-02 | 1.469 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.053045e-02 | 1.515 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.013981e-02 | 1.521 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.013981e-02 | 1.521 |
| R-HSA-1500620 | Meiosis | 3.650126e-02 | 1.438 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.800102e-02 | 1.420 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 3.813114e-02 | 1.419 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.813114e-02 | 1.419 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.813114e-02 | 1.419 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.881366e-02 | 1.411 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 3.933354e-02 | 1.405 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.938174e-02 | 1.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.138024e-02 | 1.383 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.138024e-02 | 1.383 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.676288e-02 | 1.330 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.403025e-02 | 1.356 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.676288e-02 | 1.330 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.493139e-02 | 1.347 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.957728e-02 | 1.305 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.247251e-02 | 1.280 |
| R-HSA-69205 | G1/S-Specific Transcription | 5.247251e-02 | 1.280 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.110681e-02 | 1.292 |
| R-HSA-8848021 | Signaling by PTK6 | 5.110681e-02 | 1.292 |
| R-HSA-9675108 | Nervous system development | 4.949230e-02 | 1.305 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 5.342261e-02 | 1.272 |
| R-HSA-162582 | Signal Transduction | 5.489620e-02 | 1.260 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.544761e-02 | 1.256 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 5.664966e-02 | 1.247 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 5.664966e-02 | 1.247 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 5.664966e-02 | 1.247 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 5.664966e-02 | 1.247 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 5.664966e-02 | 1.247 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.686931e-02 | 1.245 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 5.846033e-02 | 1.233 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.850154e-02 | 1.233 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.866798e-02 | 1.232 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 6.899870e-02 | 1.161 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.971465e-02 | 1.157 |
| R-HSA-72172 | mRNA Splicing | 7.364604e-02 | 1.133 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.002558e-02 | 1.222 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.971525e-02 | 1.157 |
| R-HSA-156711 | Polo-like kinase mediated events | 7.448388e-02 | 1.128 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.163323e-02 | 1.210 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 6.899870e-02 | 1.161 |
| R-HSA-180292 | GAB1 signalosome | 7.448388e-02 | 1.128 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.253709e-02 | 1.204 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 6.163323e-02 | 1.210 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.360075e-02 | 1.133 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.156859e-02 | 1.211 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 7.448388e-02 | 1.128 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 7.481277e-02 | 1.126 |
| R-HSA-9675132 | Diseases of cellular response to stress | 7.481277e-02 | 1.126 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 7.481277e-02 | 1.126 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 7.491435e-02 | 1.125 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 7.491435e-02 | 1.125 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.747747e-02 | 1.111 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 8.010311e-02 | 1.096 |
| R-HSA-4839726 | Chromatin organization | 8.231279e-02 | 1.085 |
| R-HSA-9609646 | HCMV Infection | 8.375158e-02 | 1.077 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 8.563253e-02 | 1.067 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 8.584926e-02 | 1.066 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 8.584926e-02 | 1.066 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.584926e-02 | 1.066 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.584926e-02 | 1.066 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 8.584926e-02 | 1.066 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.747817e-02 | 1.058 |
| R-HSA-9675135 | Diseases of DNA repair | 8.934251e-02 | 1.049 |
| R-HSA-75153 | Apoptotic execution phase | 8.934251e-02 | 1.049 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 9.262726e-02 | 1.033 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 9.423109e-02 | 1.026 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.100998e-01 | 0.958 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 1.100998e-01 | 0.958 |
| R-HSA-74713 | IRS activation | 1.272370e-01 | 0.895 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 1.272370e-01 | 0.895 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.440451e-01 | 0.842 |
| R-HSA-1855231 | Synthesis of IPs in the ER lumen | 1.605306e-01 | 0.794 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.605306e-01 | 0.794 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.605306e-01 | 0.794 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.766996e-01 | 0.753 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.766996e-01 | 0.753 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.766996e-01 | 0.753 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.925581e-01 | 0.715 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 2.081121e-01 | 0.682 |
| R-HSA-9613354 | Lipophagy | 2.081121e-01 | 0.682 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.233674e-01 | 0.651 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.233674e-01 | 0.651 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.530048e-01 | 0.597 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.530048e-01 | 0.597 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.226181e-01 | 0.911 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 2.815146e-01 | 0.550 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.815146e-01 | 0.550 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.815146e-01 | 0.550 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 3.089396e-01 | 0.510 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.089396e-01 | 0.510 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.222583e-01 | 0.492 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.900123e-01 | 0.721 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.970169e-01 | 0.705 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.353211e-01 | 0.475 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.298535e-01 | 0.887 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.386235e-01 | 0.858 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.606985e-01 | 0.443 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.324351e-01 | 0.634 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.730227e-01 | 0.428 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.730227e-01 | 0.428 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.707724e-01 | 0.768 |
| R-HSA-167161 | HIV Transcription Initiation | 2.467213e-01 | 0.608 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.467213e-01 | 0.608 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.252513e-01 | 0.488 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.323182e-01 | 0.478 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.673012e-01 | 0.435 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.810997e-01 | 0.419 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.555164e-01 | 0.449 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.815146e-01 | 0.550 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.488695e-01 | 0.827 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.555994e-01 | 0.808 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.953601e-01 | 0.530 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.530048e-01 | 0.597 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.353211e-01 | 0.475 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.395730e-01 | 0.621 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.949117e-01 | 0.710 |
| R-HSA-73893 | DNA Damage Bypass | 1.008648e-01 | 0.996 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.162486e-01 | 0.935 |
| R-HSA-77387 | Insulin receptor recycling | 1.422013e-01 | 0.847 |
| R-HSA-354192 | Integrin signaling | 1.761124e-01 | 0.754 |
| R-HSA-1221632 | Meiotic synapsis | 1.170898e-01 | 0.931 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.229391e-01 | 0.652 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.761124e-01 | 0.754 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.753603e-01 | 0.560 |
| R-HSA-110312 | Translesion synthesis by REV1 | 3.089396e-01 | 0.510 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.248846e-01 | 0.648 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.229391e-01 | 0.652 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.350710e-01 | 0.629 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.793871e-01 | 0.746 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.504971e-01 | 0.601 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.673979e-01 | 0.573 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.355998e-01 | 0.868 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.953601e-01 | 0.530 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.481329e-01 | 0.458 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.730227e-01 | 0.428 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.753603e-01 | 0.560 |
| R-HSA-4641265 | Repression of WNT target genes | 2.673979e-01 | 0.573 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.673979e-01 | 0.573 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.610374e-01 | 0.583 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.998381e-01 | 0.699 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.198246e-01 | 0.658 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.311429e-01 | 0.636 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.761124e-01 | 0.754 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.111162e-01 | 0.675 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.467213e-01 | 0.608 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.467213e-01 | 0.608 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.766996e-01 | 0.753 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 2.673979e-01 | 0.573 |
| R-HSA-5693538 | Homology Directed Repair | 2.561742e-01 | 0.591 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 2.530048e-01 | 0.597 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.355998e-01 | 0.868 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.467213e-01 | 0.608 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.825176e-01 | 0.549 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.825176e-01 | 0.549 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.825176e-01 | 0.549 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.810997e-01 | 0.419 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.810997e-01 | 0.419 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.810997e-01 | 0.419 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.810997e-01 | 0.419 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.948872e-01 | 0.710 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.093861e-01 | 0.961 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 1.100998e-01 | 0.958 |
| R-HSA-9636569 | Suppression of autophagy | 1.272370e-01 | 0.895 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.440451e-01 | 0.842 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.925581e-01 | 0.715 |
| R-HSA-176974 | Unwinding of DNA | 2.081121e-01 | 0.682 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.530048e-01 | 0.597 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.290703e-01 | 0.889 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.673979e-01 | 0.573 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.815146e-01 | 0.550 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.815146e-01 | 0.550 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.222583e-01 | 0.492 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.291571e-01 | 0.483 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.186014e-01 | 0.497 |
| R-HSA-69481 | G2/M Checkpoints | 1.453218e-01 | 0.838 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.889604e-01 | 0.724 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.351038e-01 | 0.869 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.673979e-01 | 0.573 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.825176e-01 | 0.549 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.925581e-01 | 0.715 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 3.089396e-01 | 0.510 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 3.353211e-01 | 0.475 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.766996e-01 | 0.753 |
| R-HSA-912446 | Meiotic recombination | 1.088590e-01 | 0.963 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.324351e-01 | 0.634 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.825176e-01 | 0.549 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.463869e-01 | 0.460 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.353211e-01 | 0.475 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.603571e-01 | 0.443 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.810997e-01 | 0.419 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.410915e-01 | 0.618 |
| R-HSA-9909396 | Circadian clock | 3.250454e-01 | 0.488 |
| R-HSA-5260271 | Diseases of Immune System | 2.324351e-01 | 0.634 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.324351e-01 | 0.634 |
| R-HSA-8981373 | Intestinal hexose absorption | 1.440451e-01 | 0.842 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.383298e-01 | 0.623 |
| R-HSA-1483226 | Synthesis of PI | 2.383298e-01 | 0.623 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 2.530048e-01 | 0.597 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.953601e-01 | 0.530 |
| R-HSA-69190 | DNA strand elongation | 1.692255e-01 | 0.772 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 3.353211e-01 | 0.475 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.606985e-01 | 0.443 |
| R-HSA-73894 | DNA Repair | 2.085517e-01 | 0.681 |
| R-HSA-8852135 | Protein ubiquitination | 2.198246e-01 | 0.658 |
| R-HSA-9664873 | Pexophagy | 2.233674e-01 | 0.651 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.605306e-01 | 0.794 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 2.081121e-01 | 0.682 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.953601e-01 | 0.530 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.761124e-01 | 0.754 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.825176e-01 | 0.549 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.774322e-01 | 0.557 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.742159e-01 | 0.427 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.162486e-01 | 0.935 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.353211e-01 | 0.475 |
| R-HSA-3928664 | Ephrin signaling | 3.606985e-01 | 0.443 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.810997e-01 | 0.419 |
| R-HSA-597592 | Post-translational protein modification | 3.584479e-01 | 0.446 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.605306e-01 | 0.794 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.766996e-01 | 0.753 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.925581e-01 | 0.715 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 2.081121e-01 | 0.682 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 2.081121e-01 | 0.682 |
| R-HSA-9683686 | Maturation of spike protein | 2.233674e-01 | 0.651 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 2.233674e-01 | 0.651 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.233674e-01 | 0.651 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.037809e-01 | 0.984 |
| R-HSA-428540 | Activation of RAC1 | 2.530048e-01 | 0.597 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.530048e-01 | 0.597 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.673979e-01 | 0.573 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.673979e-01 | 0.573 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.355998e-01 | 0.868 |
| R-HSA-418457 | cGMP effects | 2.953601e-01 | 0.530 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.089396e-01 | 0.510 |
| R-HSA-9857492 | Protein lipoylation | 3.089396e-01 | 0.510 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 3.222583e-01 | 0.492 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 3.606985e-01 | 0.443 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.730227e-01 | 0.428 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.355998e-01 | 0.868 |
| R-HSA-69206 | G1/S Transition | 1.394262e-01 | 0.856 |
| R-HSA-397014 | Muscle contraction | 2.980740e-01 | 0.526 |
| R-HSA-416700 | Other semaphorin interactions | 3.089396e-01 | 0.510 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.481329e-01 | 0.458 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.730227e-01 | 0.428 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.467213e-01 | 0.608 |
| R-HSA-180786 | Extension of Telomeres | 1.430822e-01 | 0.844 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.775132e-01 | 0.423 |
| R-HSA-1474165 | Reproduction | 1.574268e-01 | 0.803 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.272370e-01 | 0.895 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.440451e-01 | 0.842 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.440451e-01 | 0.842 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.440451e-01 | 0.842 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 1.440451e-01 | 0.842 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.766996e-01 | 0.753 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 2.081121e-01 | 0.682 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 2.081121e-01 | 0.682 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.815146e-01 | 0.550 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.815146e-01 | 0.550 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.953601e-01 | 0.530 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.953601e-01 | 0.530 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.481329e-01 | 0.458 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 3.481329e-01 | 0.458 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 3.606985e-01 | 0.443 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.119781e-01 | 0.506 |
| R-HSA-3214847 | HATs acetylate histones | 3.607755e-01 | 0.443 |
| R-HSA-5358508 | Mismatch Repair | 3.606985e-01 | 0.443 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.350710e-01 | 0.629 |
| R-HSA-157579 | Telomere Maintenance | 3.502517e-01 | 0.456 |
| R-HSA-8963676 | Intestinal absorption | 1.925581e-01 | 0.715 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.081121e-01 | 0.682 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 2.081121e-01 | 0.682 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.673979e-01 | 0.573 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.673979e-01 | 0.573 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.815146e-01 | 0.550 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.815146e-01 | 0.550 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.953601e-01 | 0.530 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.226181e-01 | 0.911 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.515075e-01 | 0.454 |
| R-HSA-74749 | Signal attenuation | 2.233674e-01 | 0.651 |
| R-HSA-9635465 | Suppression of apoptosis | 2.383298e-01 | 0.623 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.673979e-01 | 0.573 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.298535e-01 | 0.887 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.481329e-01 | 0.458 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.395730e-01 | 0.621 |
| R-HSA-9834899 | Specification of the neural plate border | 3.730227e-01 | 0.428 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.530476e-02 | 1.021 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.775132e-01 | 0.423 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.222583e-01 | 0.492 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 3.222583e-01 | 0.492 |
| R-HSA-5688426 | Deubiquitination | 2.889645e-01 | 0.539 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.909732e-01 | 0.719 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.909732e-01 | 0.719 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.673979e-01 | 0.573 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.815146e-01 | 0.550 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 3.222583e-01 | 0.492 |
| R-HSA-1266738 | Developmental Biology | 3.423159e-01 | 0.466 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.925581e-01 | 0.715 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.081121e-01 | 0.682 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.089396e-01 | 0.510 |
| R-HSA-2028269 | Signaling by Hippo | 3.481329e-01 | 0.458 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.119309e-01 | 0.951 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.561742e-01 | 0.591 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.353211e-01 | 0.475 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.606985e-01 | 0.443 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.718623e-01 | 0.566 |
| R-HSA-75893 | TNF signaling | 3.533852e-01 | 0.452 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.742078e-01 | 0.562 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.467213e-01 | 0.608 |
| R-HSA-435354 | Zinc transporters | 2.953601e-01 | 0.530 |
| R-HSA-9824446 | Viral Infection Pathways | 3.070625e-01 | 0.513 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.555994e-01 | 0.808 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.730227e-01 | 0.428 |
| R-HSA-425410 | Metal ion SLC transporters | 2.968114e-01 | 0.528 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.186014e-01 | 0.497 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.610374e-01 | 0.583 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.350710e-01 | 0.629 |
| R-HSA-1280218 | Adaptive Immune System | 2.587398e-01 | 0.587 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.607304e-01 | 0.443 |
| R-HSA-177929 | Signaling by EGFR | 1.298535e-01 | 0.887 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.512705e-01 | 0.454 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.097779e-01 | 0.678 |
| R-HSA-73887 | Death Receptor Signaling | 2.446712e-01 | 0.611 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.304410e-01 | 0.637 |
| R-HSA-9830364 | Formation of the nephric duct | 1.226181e-01 | 0.911 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 3.606985e-01 | 0.443 |
| R-HSA-109581 | Apoptosis | 2.737791e-01 | 0.563 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.680495e-01 | 0.775 |
| R-HSA-112316 | Neuronal System | 1.607103e-01 | 0.794 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.606985e-01 | 0.443 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.851100e-01 | 0.414 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.851100e-01 | 0.414 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 3.851100e-01 | 0.414 |
| R-HSA-9629569 | Protein hydroxylation | 3.851100e-01 | 0.414 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.872515e-01 | 0.412 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.879514e-01 | 0.411 |
| R-HSA-1268020 | Mitochondrial protein import | 3.947696e-01 | 0.404 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.969650e-01 | 0.401 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.969650e-01 | 0.401 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.969650e-01 | 0.401 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.969650e-01 | 0.401 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.969650e-01 | 0.401 |
| R-HSA-109582 | Hemostasis | 3.981400e-01 | 0.400 |
| R-HSA-8953854 | Metabolism of RNA | 4.002201e-01 | 0.398 |
| R-HSA-69242 | S Phase | 4.036573e-01 | 0.394 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.083004e-01 | 0.389 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.083004e-01 | 0.389 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.085922e-01 | 0.389 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 4.085922e-01 | 0.389 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 4.085922e-01 | 0.389 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.085922e-01 | 0.389 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.085922e-01 | 0.389 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.085922e-01 | 0.389 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.150108e-01 | 0.382 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.167486e-01 | 0.380 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.199959e-01 | 0.377 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 4.199959e-01 | 0.377 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 4.199959e-01 | 0.377 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.199959e-01 | 0.377 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.199959e-01 | 0.377 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 4.199959e-01 | 0.377 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.199959e-01 | 0.377 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.199959e-01 | 0.377 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.213959e-01 | 0.375 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.216830e-01 | 0.375 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.283160e-01 | 0.368 |
| R-HSA-9830369 | Kidney development | 4.283160e-01 | 0.368 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.311804e-01 | 0.365 |
| R-HSA-9018682 | Biosynthesis of maresins | 4.311804e-01 | 0.365 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.311804e-01 | 0.365 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.311804e-01 | 0.365 |
| R-HSA-167172 | Transcription of the HIV genome | 4.349089e-01 | 0.362 |
| R-HSA-74160 | Gene expression (Transcription) | 4.357048e-01 | 0.361 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.414608e-01 | 0.355 |
| R-HSA-211999 | CYP2E1 reactions | 4.421499e-01 | 0.354 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.421499e-01 | 0.354 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.421499e-01 | 0.354 |
| R-HSA-162587 | HIV Life Cycle | 4.424584e-01 | 0.354 |
| R-HSA-5357801 | Programmed Cell Death | 4.442153e-01 | 0.352 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.479707e-01 | 0.349 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.485720e-01 | 0.348 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.529085e-01 | 0.344 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.529085e-01 | 0.344 |
| R-HSA-9839394 | TGFBR3 expression | 4.529085e-01 | 0.344 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.529085e-01 | 0.344 |
| R-HSA-2160916 | Hyaluronan degradation | 4.529085e-01 | 0.344 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.529085e-01 | 0.344 |
| R-HSA-3214842 | HDMs demethylate histones | 4.529085e-01 | 0.344 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.536012e-01 | 0.343 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.544379e-01 | 0.343 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.544379e-01 | 0.343 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.586115e-01 | 0.339 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.634603e-01 | 0.334 |
| R-HSA-525793 | Myogenesis | 4.634603e-01 | 0.334 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.634603e-01 | 0.334 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.634603e-01 | 0.334 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.634603e-01 | 0.334 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.634603e-01 | 0.334 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.634603e-01 | 0.334 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.636023e-01 | 0.334 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.636023e-01 | 0.334 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.672410e-01 | 0.330 |
| R-HSA-4086398 | Ca2+ pathway | 4.672410e-01 | 0.330 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.735756e-01 | 0.325 |
| R-HSA-8949613 | Cristae formation | 4.738092e-01 | 0.324 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.738092e-01 | 0.324 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.738092e-01 | 0.324 |
| R-HSA-201451 | Signaling by BMP | 4.738092e-01 | 0.324 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.738092e-01 | 0.324 |
| R-HSA-264876 | Insulin processing | 4.738092e-01 | 0.324 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.798646e-01 | 0.319 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.798646e-01 | 0.319 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.839591e-01 | 0.315 |
| R-HSA-622312 | Inflammasomes | 4.839591e-01 | 0.315 |
| R-HSA-5620971 | Pyroptosis | 4.839591e-01 | 0.315 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.861074e-01 | 0.313 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.923036e-01 | 0.308 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 4.939139e-01 | 0.306 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.939139e-01 | 0.306 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.939139e-01 | 0.306 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.939139e-01 | 0.306 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 5.036772e-01 | 0.298 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 5.036772e-01 | 0.298 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.036772e-01 | 0.298 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 5.036772e-01 | 0.298 |
| R-HSA-112311 | Neurotransmitter clearance | 5.036772e-01 | 0.298 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 5.036772e-01 | 0.298 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.036772e-01 | 0.298 |
| R-HSA-194138 | Signaling by VEGF | 5.123294e-01 | 0.290 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 5.132527e-01 | 0.290 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 5.132527e-01 | 0.290 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.132527e-01 | 0.290 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.132527e-01 | 0.290 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.132527e-01 | 0.290 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 5.132527e-01 | 0.290 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.134111e-01 | 0.290 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.134111e-01 | 0.290 |
| R-HSA-977225 | Amyloid fiber formation | 5.166113e-01 | 0.287 |
| R-HSA-114608 | Platelet degranulation | 5.217946e-01 | 0.283 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.225669e-01 | 0.282 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.226441e-01 | 0.282 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.226441e-01 | 0.282 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.318549e-01 | 0.274 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.318549e-01 | 0.274 |
| R-HSA-9930044 | Nuclear RNA decay | 5.318549e-01 | 0.274 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.318549e-01 | 0.274 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.318549e-01 | 0.274 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.318549e-01 | 0.274 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.343298e-01 | 0.272 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.401366e-01 | 0.267 |
| R-HSA-390522 | Striated Muscle Contraction | 5.408885e-01 | 0.267 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.408885e-01 | 0.267 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 5.408885e-01 | 0.267 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.408885e-01 | 0.267 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 5.408885e-01 | 0.267 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.408885e-01 | 0.267 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.408885e-01 | 0.267 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 5.408885e-01 | 0.267 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.497483e-01 | 0.260 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.497483e-01 | 0.260 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.497483e-01 | 0.260 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.497483e-01 | 0.260 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.497483e-01 | 0.260 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 5.497483e-01 | 0.260 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.497483e-01 | 0.260 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.497483e-01 | 0.260 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 5.497483e-01 | 0.260 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.541149e-01 | 0.256 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.568731e-01 | 0.254 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.584377e-01 | 0.253 |
| R-HSA-381042 | PERK regulates gene expression | 5.584377e-01 | 0.253 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 5.584377e-01 | 0.253 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.584377e-01 | 0.253 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.584377e-01 | 0.253 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.669599e-01 | 0.246 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.669599e-01 | 0.246 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.669599e-01 | 0.246 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 5.669599e-01 | 0.246 |
| R-HSA-163560 | Triglyceride catabolism | 5.669599e-01 | 0.246 |
| R-HSA-212436 | Generic Transcription Pathway | 5.713902e-01 | 0.243 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.753181e-01 | 0.240 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.753181e-01 | 0.240 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.753181e-01 | 0.240 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 5.753181e-01 | 0.240 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.835156e-01 | 0.234 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.835156e-01 | 0.234 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.847701e-01 | 0.233 |
| R-HSA-6807070 | PTEN Regulation | 5.851057e-01 | 0.233 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.901196e-01 | 0.229 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.915552e-01 | 0.228 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.915552e-01 | 0.228 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.915552e-01 | 0.228 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.915552e-01 | 0.228 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.915552e-01 | 0.228 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.994402e-01 | 0.222 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.994402e-01 | 0.222 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.994402e-01 | 0.222 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.994402e-01 | 0.222 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.994402e-01 | 0.222 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.994402e-01 | 0.222 |
| R-HSA-202433 | Generation of second messenger molecules | 5.994402e-01 | 0.222 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.058605e-01 | 0.218 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.063869e-01 | 0.217 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 6.071735e-01 | 0.217 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 6.071735e-01 | 0.217 |
| R-HSA-9694548 | Maturation of spike protein | 6.071735e-01 | 0.217 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 6.071735e-01 | 0.217 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 6.071735e-01 | 0.217 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.110049e-01 | 0.214 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.147579e-01 | 0.211 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.147579e-01 | 0.211 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 6.147579e-01 | 0.211 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 6.147579e-01 | 0.211 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.211401e-01 | 0.207 |
| R-HSA-165159 | MTOR signalling | 6.221963e-01 | 0.206 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.221963e-01 | 0.206 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.234704e-01 | 0.205 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.269341e-01 | 0.203 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.271888e-01 | 0.203 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.294916e-01 | 0.201 |
| R-HSA-8854214 | TBC/RABGAPs | 6.294916e-01 | 0.201 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.359599e-01 | 0.197 |
| R-HSA-69236 | G1 Phase | 6.366464e-01 | 0.196 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.366464e-01 | 0.196 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.366464e-01 | 0.196 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.407982e-01 | 0.193 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.428349e-01 | 0.192 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.428349e-01 | 0.192 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.436635e-01 | 0.191 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.436635e-01 | 0.191 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.436635e-01 | 0.191 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.436635e-01 | 0.191 |
| R-HSA-1483255 | PI Metabolism | 6.455858e-01 | 0.190 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 6.505455e-01 | 0.187 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.505455e-01 | 0.187 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.505455e-01 | 0.187 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.505455e-01 | 0.187 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.505455e-01 | 0.187 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.505455e-01 | 0.187 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.505455e-01 | 0.187 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.550098e-01 | 0.184 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.550098e-01 | 0.184 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.572950e-01 | 0.182 |
| R-HSA-9833110 | RSV-host interactions | 6.596465e-01 | 0.181 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.639146e-01 | 0.178 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.639146e-01 | 0.178 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.642333e-01 | 0.178 |
| R-HSA-9711097 | Cellular response to starvation | 6.657823e-01 | 0.177 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.704067e-01 | 0.174 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.704067e-01 | 0.174 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.712890e-01 | 0.173 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.731896e-01 | 0.172 |
| R-HSA-69239 | Synthesis of DNA | 6.732577e-01 | 0.172 |
| R-HSA-109704 | PI3K Cascade | 6.767738e-01 | 0.170 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.767738e-01 | 0.170 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.776958e-01 | 0.169 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.776958e-01 | 0.169 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.776958e-01 | 0.169 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.820848e-01 | 0.166 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.820848e-01 | 0.166 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.830182e-01 | 0.166 |
| R-HSA-9679506 | SARS-CoV Infections | 6.845607e-01 | 0.165 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.864250e-01 | 0.163 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.864250e-01 | 0.163 |
| R-HSA-202403 | TCR signaling | 6.864250e-01 | 0.163 |
| R-HSA-5663205 | Infectious disease | 6.883046e-01 | 0.162 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.891424e-01 | 0.162 |
| R-HSA-72187 | mRNA 3'-end processing | 6.891424e-01 | 0.162 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.891424e-01 | 0.162 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.891424e-01 | 0.162 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.891424e-01 | 0.162 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.891424e-01 | 0.162 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.949597e-01 | 0.158 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.951487e-01 | 0.158 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.951487e-01 | 0.158 |
| R-HSA-8956320 | Nucleotide biosynthesis | 6.951487e-01 | 0.158 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.969092e-01 | 0.157 |
| R-HSA-9658195 | Leishmania infection | 6.969092e-01 | 0.157 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.991548e-01 | 0.155 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.996506e-01 | 0.155 |
| R-HSA-72649 | Translation initiation complex formation | 7.010393e-01 | 0.154 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.050627e-01 | 0.152 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 7.068164e-01 | 0.151 |
| R-HSA-9753281 | Paracetamol ADME | 7.068164e-01 | 0.151 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.068164e-01 | 0.151 |
| R-HSA-162906 | HIV Infection | 7.080368e-01 | 0.150 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.109892e-01 | 0.148 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.117745e-01 | 0.148 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.124822e-01 | 0.147 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 7.124822e-01 | 0.147 |
| R-HSA-5578775 | Ion homeostasis | 7.124822e-01 | 0.147 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.124822e-01 | 0.147 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 7.124822e-01 | 0.147 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.124822e-01 | 0.147 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.151025e-01 | 0.146 |
| R-HSA-112399 | IRS-mediated signalling | 7.180388e-01 | 0.144 |
| R-HSA-1483166 | Synthesis of PA | 7.180388e-01 | 0.144 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.180388e-01 | 0.144 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.216697e-01 | 0.142 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.233312e-01 | 0.141 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.233312e-01 | 0.141 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.234885e-01 | 0.141 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 7.234885e-01 | 0.141 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.238220e-01 | 0.140 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.249090e-01 | 0.140 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.274191e-01 | 0.138 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.281189e-01 | 0.138 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.288331e-01 | 0.137 |
| R-HSA-191859 | snRNP Assembly | 7.288331e-01 | 0.137 |
| R-HSA-8979227 | Triglyceride metabolism | 7.288331e-01 | 0.137 |
| R-HSA-186712 | Regulation of beta-cell development | 7.288331e-01 | 0.137 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.310184e-01 | 0.136 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.310184e-01 | 0.136 |
| R-HSA-1483257 | Phospholipid metabolism | 7.337318e-01 | 0.134 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 7.340747e-01 | 0.134 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.340747e-01 | 0.134 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 7.340747e-01 | 0.134 |
| R-HSA-68875 | Mitotic Prophase | 7.347937e-01 | 0.134 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.385240e-01 | 0.132 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.392154e-01 | 0.131 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.392154e-01 | 0.131 |
| R-HSA-450294 | MAP kinase activation | 7.392154e-01 | 0.131 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.392154e-01 | 0.131 |
| R-HSA-112043 | PLC beta mediated events | 7.392154e-01 | 0.131 |
| R-HSA-1442490 | Collagen degradation | 7.392154e-01 | 0.131 |
| R-HSA-168255 | Influenza Infection | 7.406663e-01 | 0.130 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.422095e-01 | 0.129 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.422095e-01 | 0.129 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.442569e-01 | 0.128 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.442569e-01 | 0.128 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.442569e-01 | 0.128 |
| R-HSA-9707616 | Heme signaling | 7.442569e-01 | 0.128 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.492013e-01 | 0.125 |
| R-HSA-8963743 | Digestion and absorption | 7.492013e-01 | 0.125 |
| R-HSA-211981 | Xenobiotics | 7.540505e-01 | 0.123 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.540505e-01 | 0.123 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.588061e-01 | 0.120 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.672185e-01 | 0.115 |
| R-HSA-112040 | G-protein mediated events | 7.680442e-01 | 0.115 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.725301e-01 | 0.112 |
| R-HSA-5218859 | Regulated Necrosis | 7.725301e-01 | 0.112 |
| R-HSA-9843745 | Adipogenesis | 7.798945e-01 | 0.108 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.812441e-01 | 0.107 |
| R-HSA-448424 | Interleukin-17 signaling | 7.812441e-01 | 0.107 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.812441e-01 | 0.107 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.812441e-01 | 0.107 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.812441e-01 | 0.107 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.830700e-01 | 0.106 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.854755e-01 | 0.105 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.854755e-01 | 0.105 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.889291e-01 | 0.103 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.896253e-01 | 0.103 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.896253e-01 | 0.103 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.896253e-01 | 0.103 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.936951e-01 | 0.100 |
| R-HSA-9749641 | Aspirin ADME | 7.936951e-01 | 0.100 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.976864e-01 | 0.098 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.976864e-01 | 0.098 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.983518e-01 | 0.098 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.016008e-01 | 0.096 |
| R-HSA-917937 | Iron uptake and transport | 8.016008e-01 | 0.096 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.065271e-01 | 0.093 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.126748e-01 | 0.090 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.128966e-01 | 0.090 |
| R-HSA-5619084 | ABC transporter disorders | 8.128966e-01 | 0.090 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 8.128966e-01 | 0.090 |
| R-HSA-216083 | Integrin cell surface interactions | 8.128966e-01 | 0.090 |
| R-HSA-9659379 | Sensory processing of sound | 8.165175e-01 | 0.088 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.165175e-01 | 0.088 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.200686e-01 | 0.086 |
| R-HSA-6798695 | Neutrophil degranulation | 8.225349e-01 | 0.085 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 8.235512e-01 | 0.084 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.235512e-01 | 0.084 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.240114e-01 | 0.084 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.269666e-01 | 0.083 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.303160e-01 | 0.081 |
| R-HSA-446728 | Cell junction organization | 8.318507e-01 | 0.080 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.336009e-01 | 0.079 |
| R-HSA-9758941 | Gastrulation | 8.361860e-01 | 0.078 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.368223e-01 | 0.077 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.386273e-01 | 0.076 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.399816e-01 | 0.076 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.410357e-01 | 0.075 |
| R-HSA-418990 | Adherens junctions interactions | 8.421587e-01 | 0.075 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.430799e-01 | 0.074 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.430799e-01 | 0.074 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.434116e-01 | 0.074 |
| R-HSA-69306 | DNA Replication | 8.457553e-01 | 0.073 |
| R-HSA-9609507 | Protein localization | 8.457553e-01 | 0.073 |
| R-HSA-70268 | Pyruvate metabolism | 8.461184e-01 | 0.073 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.480672e-01 | 0.072 |
| R-HSA-156902 | Peptide chain elongation | 8.490983e-01 | 0.071 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.490983e-01 | 0.071 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.503476e-01 | 0.070 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.520206e-01 | 0.070 |
| R-HSA-73884 | Base Excision Repair | 8.548865e-01 | 0.068 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.548865e-01 | 0.068 |
| R-HSA-392499 | Metabolism of proteins | 8.568449e-01 | 0.067 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.576971e-01 | 0.067 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.576971e-01 | 0.067 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 8.576971e-01 | 0.067 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.631566e-01 | 0.064 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.658075e-01 | 0.063 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.658075e-01 | 0.063 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.684072e-01 | 0.061 |
| R-HSA-72312 | rRNA processing | 8.685468e-01 | 0.061 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.709567e-01 | 0.060 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.734569e-01 | 0.059 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.734569e-01 | 0.059 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.759089e-01 | 0.058 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.759089e-01 | 0.058 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.783135e-01 | 0.056 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.806717e-01 | 0.055 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.806717e-01 | 0.055 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.806717e-01 | 0.055 |
| R-HSA-422356 | Regulation of insulin secretion | 8.806717e-01 | 0.055 |
| R-HSA-1643685 | Disease | 8.824864e-01 | 0.054 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.829843e-01 | 0.054 |
| R-HSA-70171 | Glycolysis | 8.852522e-01 | 0.053 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.864024e-01 | 0.052 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.874763e-01 | 0.052 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.874763e-01 | 0.052 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.881490e-01 | 0.052 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.881490e-01 | 0.052 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.896575e-01 | 0.051 |
| R-HSA-192823 | Viral mRNA Translation | 8.917965e-01 | 0.050 |
| R-HSA-1500931 | Cell-Cell communication | 8.927666e-01 | 0.049 |
| R-HSA-111885 | Opioid Signalling | 8.938941e-01 | 0.049 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.938941e-01 | 0.049 |
| R-HSA-421270 | Cell-cell junction organization | 8.981189e-01 | 0.047 |
| R-HSA-2559583 | Cellular Senescence | 8.996963e-01 | 0.046 |
| R-HSA-418346 | Platelet homeostasis | 8.999470e-01 | 0.046 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.018871e-01 | 0.045 |
| R-HSA-211000 | Gene Silencing by RNA | 9.018871e-01 | 0.045 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 9.037897e-01 | 0.044 |
| R-HSA-2672351 | Stimuli-sensing channels | 9.037897e-01 | 0.044 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.042976e-01 | 0.044 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.048390e-01 | 0.043 |
| R-HSA-6803157 | Antimicrobial peptides | 9.092797e-01 | 0.041 |
| R-HSA-1474244 | Extracellular matrix organization | 9.109093e-01 | 0.041 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.127651e-01 | 0.040 |
| R-HSA-983712 | Ion channel transport | 9.129158e-01 | 0.040 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.144574e-01 | 0.039 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.177445e-01 | 0.037 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.193405e-01 | 0.037 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.193405e-01 | 0.037 |
| R-HSA-70326 | Glucose metabolism | 9.224405e-01 | 0.035 |
| R-HSA-2980736 | Peptide hormone metabolism | 9.224405e-01 | 0.035 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 9.254217e-01 | 0.034 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.268595e-01 | 0.033 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 9.282887e-01 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.298958e-01 | 0.032 |
| R-HSA-168256 | Immune System | 9.308351e-01 | 0.031 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.310458e-01 | 0.031 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.323844e-01 | 0.030 |
| R-HSA-162909 | Host Interactions of HIV factors | 9.323844e-01 | 0.030 |
| R-HSA-977606 | Regulation of Complement cascade | 9.336972e-01 | 0.030 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 9.349845e-01 | 0.029 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 9.349845e-01 | 0.029 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 9.349845e-01 | 0.029 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.362470e-01 | 0.029 |
| R-HSA-5576891 | Cardiac conduction | 9.433246e-01 | 0.025 |
| R-HSA-195721 | Signaling by WNT | 9.472700e-01 | 0.024 |
| R-HSA-8951664 | Neddylation | 9.486784e-01 | 0.023 |
| R-HSA-163685 | Integration of energy metabolism | 9.496187e-01 | 0.022 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.515579e-01 | 0.022 |
| R-HSA-9664407 | Parasite infection | 9.534227e-01 | 0.021 |
| R-HSA-9664417 | Leishmania phagocytosis | 9.534227e-01 | 0.021 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 9.534227e-01 | 0.021 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.569402e-01 | 0.019 |
| R-HSA-166658 | Complement cascade | 9.585984e-01 | 0.018 |
| R-HSA-157118 | Signaling by NOTCH | 9.623973e-01 | 0.017 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.628115e-01 | 0.016 |
| R-HSA-2142753 | Arachidonate metabolism | 9.639165e-01 | 0.016 |
| R-HSA-1989781 | PPARA activates gene expression | 9.659818e-01 | 0.015 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.665046e-01 | 0.015 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.672927e-01 | 0.014 |
| R-HSA-9610379 | HCMV Late Events | 9.672927e-01 | 0.014 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.679292e-01 | 0.014 |
| R-HSA-168249 | Innate Immune System | 9.683912e-01 | 0.014 |
| R-HSA-877300 | Interferon gamma signaling | 9.685533e-01 | 0.014 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.714970e-01 | 0.013 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.731296e-01 | 0.012 |
| R-HSA-5619102 | SLC transporter disorders | 9.731296e-01 | 0.012 |
| R-HSA-72306 | tRNA processing | 9.751623e-01 | 0.011 |
| R-HSA-72766 | Translation | 9.760529e-01 | 0.011 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.764006e-01 | 0.010 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.842054e-01 | 0.007 |
| R-HSA-428157 | Sphingolipid metabolism | 9.865086e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.869428e-01 | 0.006 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.870300e-01 | 0.006 |
| R-HSA-6805567 | Keratinization | 9.880134e-01 | 0.005 |
| R-HSA-9748784 | Drug ADME | 9.905394e-01 | 0.004 |
| R-HSA-8957322 | Metabolism of steroids | 9.909105e-01 | 0.004 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.925345e-01 | 0.003 |
| R-HSA-15869 | Metabolism of nucleotides | 9.933686e-01 | 0.003 |
| R-HSA-416476 | G alpha (q) signalling events | 9.961875e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.977067e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.984740e-01 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.991213e-01 | 0.000 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.991722e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.994762e-01 | 0.000 |
| R-HSA-449147 | Signaling by Interleukins | 9.997298e-01 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 9.997822e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.997822e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998687e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.998875e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999818e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999944e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999969e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.886 | 0.330 | 1 | 0.864 |
COT |
0.884 | 0.160 | 2 | 0.856 |
CDC7 |
0.882 | 0.192 | 1 | 0.912 |
MOS |
0.879 | 0.264 | 1 | 0.923 |
PIM3 |
0.871 | 0.108 | -3 | 0.794 |
KIS |
0.869 | 0.211 | 1 | 0.734 |
NDR2 |
0.869 | 0.086 | -3 | 0.793 |
PRPK |
0.868 | -0.110 | -1 | 0.872 |
NLK |
0.867 | 0.092 | 1 | 0.852 |
MTOR |
0.867 | -0.045 | 1 | 0.801 |
RAF1 |
0.867 | -0.048 | 1 | 0.839 |
BMPR1B |
0.866 | 0.311 | 1 | 0.856 |
ERK5 |
0.866 | 0.111 | 1 | 0.854 |
CAMK1B |
0.866 | 0.031 | -3 | 0.826 |
CDKL1 |
0.865 | 0.081 | -3 | 0.766 |
DSTYK |
0.865 | 0.022 | 2 | 0.866 |
ATR |
0.865 | 0.047 | 1 | 0.841 |
BMPR2 |
0.864 | -0.036 | -2 | 0.902 |
GCN2 |
0.863 | -0.126 | 2 | 0.774 |
IKKB |
0.863 | -0.101 | -2 | 0.768 |
SRPK1 |
0.863 | 0.131 | -3 | 0.719 |
GRK1 |
0.863 | 0.163 | -2 | 0.839 |
HIPK4 |
0.863 | 0.163 | 1 | 0.797 |
RSK2 |
0.861 | 0.098 | -3 | 0.738 |
SKMLCK |
0.861 | 0.090 | -2 | 0.888 |
PDHK4 |
0.861 | -0.279 | 1 | 0.852 |
CDKL5 |
0.861 | 0.097 | -3 | 0.758 |
CAMK2G |
0.861 | -0.067 | 2 | 0.804 |
TBK1 |
0.861 | -0.110 | 1 | 0.719 |
TGFBR2 |
0.860 | 0.042 | -2 | 0.846 |
PIM1 |
0.859 | 0.115 | -3 | 0.745 |
PRKD1 |
0.859 | 0.076 | -3 | 0.773 |
NEK6 |
0.859 | -0.007 | -2 | 0.872 |
GRK5 |
0.858 | -0.064 | -3 | 0.823 |
DAPK2 |
0.858 | 0.052 | -3 | 0.829 |
NIK |
0.857 | -0.032 | -3 | 0.838 |
TGFBR1 |
0.857 | 0.201 | -2 | 0.865 |
NDR1 |
0.857 | 0.009 | -3 | 0.789 |
PRKD2 |
0.857 | 0.095 | -3 | 0.727 |
CAMLCK |
0.857 | 0.023 | -2 | 0.878 |
FAM20C |
0.857 | 0.163 | 2 | 0.650 |
ICK |
0.856 | 0.095 | -3 | 0.798 |
AURC |
0.856 | 0.146 | -2 | 0.710 |
IKKE |
0.856 | -0.143 | 1 | 0.713 |
WNK1 |
0.856 | -0.018 | -2 | 0.887 |
MST4 |
0.856 | 0.024 | 2 | 0.832 |
NUAK2 |
0.856 | 0.006 | -3 | 0.806 |
PKN3 |
0.855 | -0.016 | -3 | 0.782 |
GRK6 |
0.855 | 0.033 | 1 | 0.851 |
ULK2 |
0.855 | -0.201 | 2 | 0.758 |
IKKA |
0.854 | 0.007 | -2 | 0.760 |
ALK4 |
0.854 | 0.143 | -2 | 0.886 |
P90RSK |
0.854 | 0.031 | -3 | 0.740 |
SRPK2 |
0.854 | 0.104 | -3 | 0.640 |
NEK7 |
0.854 | -0.130 | -3 | 0.811 |
PDHK1 |
0.854 | -0.269 | 1 | 0.821 |
MARK4 |
0.853 | -0.012 | 4 | 0.845 |
LATS2 |
0.853 | 0.013 | -5 | 0.768 |
CLK2 |
0.853 | 0.227 | -3 | 0.718 |
HUNK |
0.853 | -0.081 | 2 | 0.795 |
AMPKA1 |
0.853 | 0.009 | -3 | 0.810 |
CHAK2 |
0.852 | -0.028 | -1 | 0.873 |
LATS1 |
0.852 | 0.132 | -3 | 0.810 |
GRK7 |
0.852 | 0.150 | 1 | 0.793 |
CLK4 |
0.852 | 0.147 | -3 | 0.736 |
RSK3 |
0.852 | 0.024 | -3 | 0.730 |
RIPK3 |
0.851 | -0.125 | 3 | 0.718 |
CDK8 |
0.851 | 0.093 | 1 | 0.701 |
DYRK2 |
0.851 | 0.141 | 1 | 0.731 |
CLK1 |
0.850 | 0.161 | -3 | 0.713 |
MLK1 |
0.850 | -0.133 | 2 | 0.782 |
PKACG |
0.850 | 0.046 | -2 | 0.798 |
P70S6KB |
0.850 | 0.020 | -3 | 0.757 |
ALK2 |
0.850 | 0.197 | -2 | 0.873 |
CDK1 |
0.850 | 0.149 | 1 | 0.689 |
PKN2 |
0.850 | -0.021 | -3 | 0.794 |
ACVR2B |
0.850 | 0.163 | -2 | 0.843 |
MAPKAPK2 |
0.849 | 0.050 | -3 | 0.685 |
PKCD |
0.849 | 0.026 | 2 | 0.752 |
ATM |
0.849 | 0.024 | 1 | 0.788 |
MAPKAPK3 |
0.848 | -0.016 | -3 | 0.729 |
GRK4 |
0.848 | -0.065 | -2 | 0.858 |
SRPK3 |
0.848 | 0.070 | -3 | 0.688 |
BMPR1A |
0.848 | 0.257 | 1 | 0.835 |
ACVR2A |
0.848 | 0.133 | -2 | 0.830 |
CAMK2D |
0.848 | -0.061 | -3 | 0.792 |
TSSK1 |
0.847 | 0.039 | -3 | 0.829 |
JNK2 |
0.847 | 0.157 | 1 | 0.670 |
P38A |
0.847 | 0.145 | 1 | 0.756 |
CDK18 |
0.847 | 0.149 | 1 | 0.661 |
CAMK2B |
0.847 | 0.045 | 2 | 0.782 |
TSSK2 |
0.846 | -0.012 | -5 | 0.856 |
CDK19 |
0.846 | 0.100 | 1 | 0.666 |
CDK5 |
0.846 | 0.130 | 1 | 0.744 |
AMPKA2 |
0.845 | -0.002 | -3 | 0.777 |
HIPK2 |
0.845 | 0.186 | 1 | 0.652 |
CAMK2A |
0.845 | 0.045 | 2 | 0.790 |
RSK4 |
0.845 | 0.087 | -3 | 0.705 |
CDK7 |
0.845 | 0.069 | 1 | 0.727 |
PKACB |
0.845 | 0.116 | -2 | 0.727 |
BCKDK |
0.844 | -0.210 | -1 | 0.813 |
ULK1 |
0.844 | -0.230 | -3 | 0.781 |
DLK |
0.844 | -0.199 | 1 | 0.818 |
PKR |
0.844 | 0.011 | 1 | 0.824 |
P38B |
0.844 | 0.152 | 1 | 0.692 |
JNK3 |
0.844 | 0.124 | 1 | 0.705 |
WNK3 |
0.844 | -0.279 | 1 | 0.798 |
ANKRD3 |
0.844 | -0.173 | 1 | 0.839 |
MASTL |
0.843 | -0.338 | -2 | 0.825 |
PRKX |
0.843 | 0.152 | -3 | 0.650 |
AURB |
0.843 | 0.075 | -2 | 0.704 |
HIPK1 |
0.842 | 0.155 | 1 | 0.744 |
MLK3 |
0.842 | -0.037 | 2 | 0.702 |
CAMK4 |
0.842 | -0.086 | -3 | 0.775 |
NEK9 |
0.842 | -0.214 | 2 | 0.808 |
PLK1 |
0.841 | -0.060 | -2 | 0.820 |
IRE1 |
0.841 | -0.105 | 1 | 0.771 |
NIM1 |
0.841 | -0.103 | 3 | 0.764 |
PAK1 |
0.841 | -0.010 | -2 | 0.810 |
MEK1 |
0.841 | -0.142 | 2 | 0.812 |
PRKD3 |
0.840 | 0.018 | -3 | 0.707 |
ERK1 |
0.840 | 0.117 | 1 | 0.680 |
MLK2 |
0.840 | -0.184 | 2 | 0.784 |
QSK |
0.840 | 0.003 | 4 | 0.823 |
MSK2 |
0.840 | -0.024 | -3 | 0.701 |
CDK13 |
0.840 | 0.061 | 1 | 0.699 |
MSK1 |
0.840 | 0.045 | -3 | 0.707 |
RIPK1 |
0.839 | -0.244 | 1 | 0.791 |
CDK17 |
0.839 | 0.114 | 1 | 0.611 |
DNAPK |
0.839 | 0.036 | 1 | 0.720 |
P38G |
0.839 | 0.122 | 1 | 0.605 |
MNK2 |
0.838 | 0.007 | -2 | 0.817 |
CDK3 |
0.838 | 0.154 | 1 | 0.633 |
MELK |
0.838 | -0.051 | -3 | 0.760 |
GRK2 |
0.838 | 0.006 | -2 | 0.762 |
PIM2 |
0.838 | 0.069 | -3 | 0.712 |
MYLK4 |
0.838 | 0.010 | -2 | 0.810 |
NUAK1 |
0.838 | -0.057 | -3 | 0.750 |
PRP4 |
0.837 | 0.104 | -3 | 0.742 |
TTBK2 |
0.837 | -0.229 | 2 | 0.666 |
AURA |
0.837 | 0.050 | -2 | 0.673 |
PKCA |
0.837 | 0.001 | 2 | 0.692 |
PAK3 |
0.837 | -0.068 | -2 | 0.805 |
AKT2 |
0.837 | 0.062 | -3 | 0.660 |
PKG2 |
0.837 | 0.058 | -2 | 0.734 |
DYRK1A |
0.837 | 0.097 | 1 | 0.771 |
VRK2 |
0.836 | -0.255 | 1 | 0.856 |
CDK2 |
0.836 | 0.057 | 1 | 0.759 |
PKCB |
0.836 | -0.021 | 2 | 0.698 |
QIK |
0.836 | -0.117 | -3 | 0.792 |
PKCG |
0.836 | -0.029 | 2 | 0.697 |
SIK |
0.836 | -0.018 | -3 | 0.717 |
SGK3 |
0.836 | 0.046 | -3 | 0.724 |
PLK3 |
0.836 | -0.061 | 2 | 0.758 |
DYRK4 |
0.836 | 0.144 | 1 | 0.670 |
YSK4 |
0.836 | -0.157 | 1 | 0.763 |
MARK3 |
0.835 | 0.007 | 4 | 0.789 |
PAK6 |
0.835 | 0.035 | -2 | 0.731 |
SMG1 |
0.835 | -0.058 | 1 | 0.790 |
IRE2 |
0.835 | -0.105 | 2 | 0.730 |
MNK1 |
0.835 | 0.017 | -2 | 0.829 |
HIPK3 |
0.834 | 0.108 | 1 | 0.743 |
CHK1 |
0.834 | -0.035 | -3 | 0.781 |
TLK2 |
0.834 | -0.058 | 1 | 0.773 |
ERK2 |
0.834 | 0.057 | 1 | 0.719 |
CDK14 |
0.834 | 0.121 | 1 | 0.698 |
P38D |
0.834 | 0.152 | 1 | 0.625 |
BRSK1 |
0.833 | -0.046 | -3 | 0.747 |
PASK |
0.833 | 0.075 | -3 | 0.812 |
MLK4 |
0.833 | -0.091 | 2 | 0.681 |
NEK2 |
0.833 | -0.133 | 2 | 0.782 |
CDK12 |
0.833 | 0.061 | 1 | 0.671 |
DRAK1 |
0.832 | -0.047 | 1 | 0.808 |
MARK2 |
0.832 | -0.025 | 4 | 0.747 |
CK2A2 |
0.832 | 0.168 | 1 | 0.818 |
PHKG1 |
0.831 | -0.102 | -3 | 0.777 |
MPSK1 |
0.831 | 0.098 | 1 | 0.782 |
DCAMKL1 |
0.831 | -0.007 | -3 | 0.744 |
CK1E |
0.831 | 0.020 | -3 | 0.559 |
PKCZ |
0.831 | -0.075 | 2 | 0.746 |
PAK2 |
0.831 | -0.080 | -2 | 0.795 |
CDK16 |
0.831 | 0.138 | 1 | 0.628 |
PKCH |
0.830 | -0.068 | 2 | 0.687 |
BRAF |
0.830 | -0.085 | -4 | 0.848 |
PERK |
0.830 | -0.110 | -2 | 0.865 |
DYRK1B |
0.830 | 0.102 | 1 | 0.703 |
CDK9 |
0.830 | 0.027 | 1 | 0.705 |
GAK |
0.830 | 0.120 | 1 | 0.866 |
CHAK1 |
0.829 | -0.184 | 2 | 0.743 |
CDK10 |
0.829 | 0.128 | 1 | 0.686 |
MARK1 |
0.828 | -0.047 | 4 | 0.807 |
PKACA |
0.828 | 0.077 | -2 | 0.683 |
DYRK3 |
0.828 | 0.095 | 1 | 0.738 |
BRSK2 |
0.827 | -0.121 | -3 | 0.769 |
CAMK1G |
0.827 | -0.063 | -3 | 0.719 |
PINK1 |
0.827 | -0.134 | 1 | 0.823 |
MST3 |
0.827 | -0.017 | 2 | 0.810 |
SMMLCK |
0.827 | -0.023 | -3 | 0.777 |
HRI |
0.826 | -0.198 | -2 | 0.870 |
TLK1 |
0.826 | -0.095 | -2 | 0.866 |
NEK5 |
0.826 | -0.117 | 1 | 0.815 |
CK1D |
0.826 | 0.034 | -3 | 0.507 |
TAO3 |
0.825 | -0.041 | 1 | 0.791 |
MEK5 |
0.825 | -0.310 | 2 | 0.793 |
GRK3 |
0.825 | 0.004 | -2 | 0.726 |
MEKK3 |
0.825 | -0.209 | 1 | 0.791 |
PDHK3_TYR |
0.825 | 0.231 | 4 | 0.887 |
MAK |
0.824 | 0.183 | -2 | 0.766 |
AKT1 |
0.824 | 0.048 | -3 | 0.674 |
MEKK2 |
0.824 | -0.148 | 2 | 0.769 |
WNK4 |
0.824 | -0.150 | -2 | 0.871 |
DAPK3 |
0.824 | 0.060 | -3 | 0.759 |
MEKK1 |
0.824 | -0.220 | 1 | 0.780 |
GSK3A |
0.824 | 0.051 | 4 | 0.447 |
MAPKAPK5 |
0.823 | -0.153 | -3 | 0.672 |
DCAMKL2 |
0.823 | -0.060 | -3 | 0.771 |
IRAK4 |
0.822 | -0.141 | 1 | 0.770 |
PLK4 |
0.822 | -0.188 | 2 | 0.609 |
JNK1 |
0.821 | 0.086 | 1 | 0.665 |
GSK3B |
0.821 | -0.009 | 4 | 0.439 |
ZAK |
0.821 | -0.222 | 1 | 0.746 |
LKB1 |
0.820 | -0.043 | -3 | 0.791 |
SNRK |
0.820 | -0.271 | 2 | 0.658 |
ERK7 |
0.820 | 0.033 | 2 | 0.519 |
CK2A1 |
0.820 | 0.132 | 1 | 0.799 |
SSTK |
0.820 | -0.035 | 4 | 0.820 |
CAMK1D |
0.820 | -0.007 | -3 | 0.650 |
CK1A2 |
0.820 | 0.007 | -3 | 0.508 |
P70S6K |
0.820 | -0.044 | -3 | 0.669 |
NEK8 |
0.818 | -0.162 | 2 | 0.790 |
GCK |
0.818 | -0.008 | 1 | 0.798 |
CDK6 |
0.817 | 0.089 | 1 | 0.679 |
DAPK1 |
0.817 | 0.039 | -3 | 0.744 |
CAMKK1 |
0.817 | -0.169 | -2 | 0.772 |
PKCT |
0.817 | -0.074 | 2 | 0.693 |
TAO2 |
0.817 | -0.121 | 2 | 0.820 |
PHKG2 |
0.816 | -0.097 | -3 | 0.757 |
PDHK4_TYR |
0.816 | 0.095 | 2 | 0.864 |
MAP2K4_TYR |
0.816 | 0.043 | -1 | 0.888 |
PLK2 |
0.815 | 0.018 | -3 | 0.784 |
BUB1 |
0.815 | 0.144 | -5 | 0.814 |
MAP2K6_TYR |
0.815 | 0.062 | -1 | 0.887 |
PDK1 |
0.815 | -0.122 | 1 | 0.788 |
EEF2K |
0.815 | -0.040 | 3 | 0.822 |
TESK1_TYR |
0.815 | -0.016 | 3 | 0.881 |
PKCI |
0.814 | -0.062 | 2 | 0.712 |
CAMKK2 |
0.814 | -0.158 | -2 | 0.771 |
CK1G1 |
0.814 | -0.066 | -3 | 0.551 |
TNIK |
0.814 | 0.000 | 3 | 0.857 |
NEK11 |
0.814 | -0.243 | 1 | 0.779 |
MST2 |
0.814 | -0.104 | 1 | 0.801 |
MOK |
0.814 | 0.119 | 1 | 0.765 |
PAK5 |
0.813 | -0.031 | -2 | 0.671 |
SGK1 |
0.813 | 0.055 | -3 | 0.580 |
PKCE |
0.813 | 0.001 | 2 | 0.687 |
ROCK2 |
0.813 | 0.075 | -3 | 0.747 |
BMPR2_TYR |
0.813 | 0.044 | -1 | 0.881 |
CDK4 |
0.812 | 0.071 | 1 | 0.657 |
TAK1 |
0.812 | -0.108 | 1 | 0.806 |
AKT3 |
0.812 | 0.050 | -3 | 0.595 |
PDHK1_TYR |
0.811 | 0.011 | -1 | 0.900 |
MRCKA |
0.811 | 0.038 | -3 | 0.713 |
MINK |
0.811 | -0.091 | 1 | 0.770 |
HPK1 |
0.810 | -0.052 | 1 | 0.780 |
NEK4 |
0.810 | -0.175 | 1 | 0.768 |
CHK2 |
0.810 | -0.012 | -3 | 0.604 |
HGK |
0.810 | -0.090 | 3 | 0.852 |
MRCKB |
0.810 | 0.038 | -3 | 0.698 |
PKMYT1_TYR |
0.810 | -0.076 | 3 | 0.850 |
TTBK1 |
0.810 | -0.254 | 2 | 0.588 |
LRRK2 |
0.809 | -0.180 | 2 | 0.823 |
PBK |
0.809 | 0.047 | 1 | 0.804 |
MEKK6 |
0.809 | -0.164 | 1 | 0.781 |
PAK4 |
0.809 | -0.028 | -2 | 0.678 |
MAP2K7_TYR |
0.809 | -0.240 | 2 | 0.840 |
MAP3K15 |
0.809 | -0.162 | 1 | 0.741 |
IRAK1 |
0.808 | -0.331 | -1 | 0.774 |
EPHA6 |
0.808 | 0.066 | -1 | 0.872 |
DMPK1 |
0.807 | 0.098 | -3 | 0.722 |
NEK1 |
0.807 | -0.132 | 1 | 0.780 |
LIMK2_TYR |
0.807 | -0.015 | -3 | 0.842 |
EPHB4 |
0.806 | 0.063 | -1 | 0.849 |
TXK |
0.806 | 0.175 | 1 | 0.883 |
PINK1_TYR |
0.806 | -0.183 | 1 | 0.842 |
PKN1 |
0.806 | -0.059 | -3 | 0.688 |
LOK |
0.805 | -0.094 | -2 | 0.790 |
KHS1 |
0.805 | -0.033 | 1 | 0.762 |
KHS2 |
0.805 | 0.002 | 1 | 0.779 |
MST1 |
0.805 | -0.133 | 1 | 0.776 |
VRK1 |
0.805 | -0.220 | 2 | 0.827 |
CAMK1A |
0.805 | -0.013 | -3 | 0.614 |
SBK |
0.804 | 0.023 | -3 | 0.542 |
ABL2 |
0.803 | 0.075 | -1 | 0.819 |
YES1 |
0.802 | 0.038 | -1 | 0.865 |
SLK |
0.802 | -0.106 | -2 | 0.740 |
MEK2 |
0.801 | -0.280 | 2 | 0.781 |
RET |
0.800 | -0.146 | 1 | 0.783 |
FGR |
0.800 | -0.011 | 1 | 0.862 |
TTK |
0.800 | -0.009 | -2 | 0.844 |
LCK |
0.799 | 0.101 | -1 | 0.843 |
BLK |
0.799 | 0.131 | -1 | 0.847 |
TYRO3 |
0.799 | -0.121 | 3 | 0.786 |
EPHA4 |
0.798 | 0.015 | 2 | 0.764 |
YSK1 |
0.798 | -0.148 | 2 | 0.778 |
ABL1 |
0.798 | 0.038 | -1 | 0.813 |
LIMK1_TYR |
0.798 | -0.233 | 2 | 0.829 |
FER |
0.798 | -0.060 | 1 | 0.888 |
HCK |
0.797 | -0.001 | -1 | 0.839 |
MST1R |
0.796 | -0.181 | 3 | 0.805 |
CSF1R |
0.796 | -0.097 | 3 | 0.785 |
BIKE |
0.796 | 0.061 | 1 | 0.752 |
SRMS |
0.796 | 0.005 | 1 | 0.870 |
ROCK1 |
0.796 | 0.028 | -3 | 0.710 |
DDR1 |
0.795 | -0.188 | 4 | 0.824 |
TYK2 |
0.795 | -0.249 | 1 | 0.778 |
CRIK |
0.795 | 0.030 | -3 | 0.670 |
ROS1 |
0.795 | -0.162 | 3 | 0.747 |
EPHB1 |
0.795 | -0.020 | 1 | 0.857 |
TNK2 |
0.795 | -0.022 | 3 | 0.754 |
EPHB2 |
0.795 | 0.034 | -1 | 0.827 |
JAK2 |
0.795 | -0.187 | 1 | 0.772 |
OSR1 |
0.794 | -0.089 | 2 | 0.762 |
HASPIN |
0.794 | 0.021 | -1 | 0.760 |
INSRR |
0.793 | -0.088 | 3 | 0.728 |
FYN |
0.793 | 0.094 | -1 | 0.824 |
STK33 |
0.793 | -0.247 | 2 | 0.579 |
ITK |
0.793 | -0.025 | -1 | 0.806 |
EPHB3 |
0.792 | -0.027 | -1 | 0.829 |
PKG1 |
0.792 | -0.019 | -2 | 0.648 |
RIPK2 |
0.792 | -0.370 | 1 | 0.714 |
JAK3 |
0.791 | -0.153 | 1 | 0.774 |
ALPHAK3 |
0.791 | -0.044 | -1 | 0.781 |
NEK3 |
0.789 | -0.226 | 1 | 0.734 |
MYO3B |
0.789 | -0.084 | 2 | 0.793 |
MERTK |
0.789 | -0.058 | 3 | 0.768 |
TEC |
0.788 | -0.027 | -1 | 0.750 |
KIT |
0.788 | -0.141 | 3 | 0.792 |
BMX |
0.787 | -0.030 | -1 | 0.726 |
FGFR2 |
0.787 | -0.174 | 3 | 0.787 |
TNK1 |
0.786 | -0.112 | 3 | 0.766 |
ASK1 |
0.786 | -0.215 | 1 | 0.727 |
KDR |
0.786 | -0.144 | 3 | 0.747 |
EPHA7 |
0.785 | -0.049 | 2 | 0.761 |
MET |
0.785 | -0.101 | 3 | 0.783 |
PDGFRB |
0.784 | -0.234 | 3 | 0.795 |
FLT3 |
0.784 | -0.187 | 3 | 0.786 |
PTK2B |
0.784 | 0.015 | -1 | 0.794 |
NEK10_TYR |
0.784 | -0.166 | 1 | 0.674 |
MYO3A |
0.784 | -0.133 | 1 | 0.752 |
BTK |
0.784 | -0.168 | -1 | 0.771 |
JAK1 |
0.783 | -0.136 | 1 | 0.721 |
AAK1 |
0.783 | 0.114 | 1 | 0.658 |
YANK3 |
0.783 | -0.113 | 2 | 0.376 |
EPHA3 |
0.783 | -0.110 | 2 | 0.733 |
AXL |
0.782 | -0.178 | 3 | 0.763 |
LYN |
0.782 | -0.037 | 3 | 0.701 |
CK1A |
0.782 | -0.031 | -3 | 0.423 |
TNNI3K_TYR |
0.782 | -0.130 | 1 | 0.767 |
TAO1 |
0.781 | -0.164 | 1 | 0.705 |
PTK2 |
0.781 | 0.070 | -1 | 0.803 |
TEK |
0.781 | -0.227 | 3 | 0.720 |
LTK |
0.781 | -0.144 | 3 | 0.735 |
EPHA5 |
0.781 | -0.015 | 2 | 0.749 |
FRK |
0.780 | -0.081 | -1 | 0.842 |
ALK |
0.780 | -0.164 | 3 | 0.707 |
FGFR1 |
0.780 | -0.236 | 3 | 0.755 |
SRC |
0.779 | -0.020 | -1 | 0.824 |
WEE1_TYR |
0.779 | -0.149 | -1 | 0.760 |
FLT1 |
0.779 | -0.142 | -1 | 0.840 |
EPHA1 |
0.778 | -0.125 | 3 | 0.759 |
NTRK1 |
0.777 | -0.239 | -1 | 0.826 |
FGFR3 |
0.776 | -0.188 | 3 | 0.758 |
DDR2 |
0.776 | -0.078 | 3 | 0.721 |
ERBB2 |
0.776 | -0.211 | 1 | 0.748 |
PTK6 |
0.775 | -0.248 | -1 | 0.738 |
EPHA8 |
0.775 | -0.069 | -1 | 0.809 |
SYK |
0.775 | 0.052 | -1 | 0.779 |
PDGFRA |
0.774 | -0.334 | 3 | 0.793 |
NTRK2 |
0.773 | -0.255 | 3 | 0.744 |
INSR |
0.772 | -0.214 | 3 | 0.700 |
MATK |
0.772 | -0.146 | -1 | 0.744 |
NTRK3 |
0.771 | -0.190 | -1 | 0.775 |
FLT4 |
0.770 | -0.268 | 3 | 0.739 |
EGFR |
0.769 | -0.116 | 1 | 0.654 |
STLK3 |
0.769 | -0.309 | 1 | 0.718 |
CSK |
0.767 | -0.192 | 2 | 0.758 |
FGFR4 |
0.765 | -0.143 | -1 | 0.777 |
EPHA2 |
0.765 | -0.079 | -1 | 0.777 |
IGF1R |
0.760 | -0.183 | 3 | 0.642 |
CK1G3 |
0.759 | -0.057 | -3 | 0.377 |
ERBB4 |
0.759 | -0.087 | 1 | 0.684 |
MUSK |
0.756 | -0.216 | 1 | 0.656 |
FES |
0.750 | -0.161 | -1 | 0.709 |
YANK2 |
0.749 | -0.143 | 2 | 0.389 |
ZAP70 |
0.749 | -0.037 | -1 | 0.700 |
CK1G2 |
0.742 | -0.055 | -3 | 0.467 |