Motif 631 (n=104)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NKT7 | RGPD3 | S1312 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
A6NKT7 | RGPD3 | S1587 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
F8WAN1 | SPECC1L-ADORA2A | S389 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
M0R1B8 | None | S30 | ochoa | Uncharacterized protein | None |
O00571 | DDX3X | S28 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
O14715 | RGPD8 | S1586 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O43491 | EPB41L2 | S676 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O60361 | NME2P1 | S107 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
O75376 | NCOR1 | S2352 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O75995 | SASH3 | S117 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
O95292 | VAPB | S156 | ochoa | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
O95684 | CEP43 | S345 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
P07900 | HSP90AA1 | T540 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
P08238 | HSP90AB1 | S532 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
P0DJD0 | RGPD1 | S1296 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | S1304 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P10809 | HSPD1 | S232 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
P12830 | CDH1 | S847 | psp | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
P13010 | XRCC5 | S692 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
P13804 | ETFA | S179 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
P15531 | NME1 | S122 | ochoa|psp | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
P15884 | TCF4 | S505 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
P21796 | VDAC1 | S43 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
P22392 | NME2 | S122 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
P23588 | EIF4B | S504 | ochoa|psp | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
P25054 | APC | S2140 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
P41227 | NAA10 | S213 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
P42166 | TMPO | S177 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
P43487 | RANBP1 | S21 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
P46821 | MAP1B | S1415 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P49023 | PXN | S137 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
P49792 | RANBP2 | S2287 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P49792 | RANBP2 | S2562 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P51114 | FXR1 | S420 | ochoa|psp | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
P54725 | RAD23A | S140 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
Q02156 | PRKCE | S344 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
Q02952 | AKAP12 | S386 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
Q04656 | ATP7A | S1473 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
Q07157 | TJP1 | S828 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q09666 | AHNAK | S5746 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q12888 | TP53BP1 | S310 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12888 | TP53BP1 | S530 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12888 | TP53BP1 | S1034 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q13113 | PDZK1IP1 | S89 | ochoa | PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96) | Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1 (PubMed:34880493, PubMed:37217492, PubMed:38057552). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (PubMed:37217492). {ECO:0000269|PubMed:34880493, ECO:0000269|PubMed:37217492, ECO:0000269|PubMed:38057552}. |
Q13492 | PICALM | S315 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
Q13796 | SHROOM2 | S174 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Q14005 | IL16 | S1080 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
Q14103 | HNRNPD | S80 | ochoa | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
Q15398 | DLGAP5 | S774 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
Q4KMP7 | TBC1D10B | S274 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
Q58FF7 | HSP90AB3P | S405 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
Q58FF8 | HSP90AB2P | S305 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
Q58FG1 | HSP90AA4P | T248 | ochoa | Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
Q5T1M5 | FKBP15 | S1097 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
Q5T200 | ZC3H13 | S1452 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
Q5THJ4 | VPS13D | S2689 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q5UIP0 | RIF1 | S1703 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q5VZL5 | ZMYM4 | S242 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Q5W0B1 | OBI1 | S568 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
Q658Y4 | FAM91A1 | S691 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
Q68DQ2 | CRYBG3 | S2101 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
Q69YQ0 | SPECC1L | S389 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
Q6ZMT1 | STAC2 | S228 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
Q7Z3J3 | RGPD4 | S1312 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z3J3 | RGPD4 | S1587 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z401 | DENND4A | S912 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q86UE8 | TLK2 | S38 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
Q86VM9 | ZC3H18 | S53 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
Q86WR7 | PROSER2 | S50 | ochoa | Proline and serine-rich protein 2 | None |
Q86X95 | CIR1 | S196 | ochoa | Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) | May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}. |
Q8IUF8 | RIOX2 | S44 | ochoa | Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}. |
Q8N163 | CCAR2 | S675 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
Q8N4X5 | AFAP1L2 | S303 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
Q8NC44 | RETREG2 | S344 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
Q8TEV9 | SMCR8 | S421 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
Q8WU90 | ZC3H15 | S368 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
Q96QC0 | PPP1R10 | S591 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
Q96S94 | CCNL2 | S345 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
Q96ST2 | IWS1 | S426 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
Q99081 | TCF12 | S553 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
Q99666 | RGPD5 | S1586 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9BSQ5 | CCM2 | S245 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
Q9BX66 | SORBS1 | S472 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
Q9BXF6 | RAB11FIP5 | S361 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
Q9BYW2 | SETD2 | S1885 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9H0H5 | RACGAP1 | S164 | ochoa|psp | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
Q9H0H5 | RACGAP1 | S274 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
Q9HD67 | MYO10 | S962 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
Q9NSC5 | HOMER3 | S135 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
Q9NSI6 | BRWD1 | S2011 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
Q9NWQ8 | PAG1 | S295 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
Q9NX63 | CHCHD3 | Y53 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
Q9P266 | JCAD | S1321 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
Q9UHD1 | CHORDC1 | S125 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
Q9UHW9 | SLC12A6 | S93 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
Q9UKI8 | TLK1 | S97 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Q9UKY7 | CDV3 | S197 | ochoa | Protein CDV3 homolog | None |
Q9UQ35 | SRRM2 | S864 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2M0 | FAN1 | S191 | ochoa | Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}. |
Q9Y490 | TLN1 | S405 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
Q9Y4F3 | MARF1 | S709 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
Q99816 | TSG101 | S229 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
O15143 | ARPC1B | S330 | Sugiyama | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
Q9UQ80 | PA2G4 | S44 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.000026 | 4.581 |
R-HSA-9823730 | Formation of definitive endoderm | 0.000832 | 3.080 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.001585 | 2.800 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.001997 | 2.700 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.002454 | 2.610 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.002955 | 2.529 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.002730 | 2.564 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.004089 | 2.388 |
R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.004089 | 2.388 |
R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.003501 | 2.456 |
R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.007178 | 2.144 |
R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.021381 | 1.670 |
R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 0.021381 | 1.670 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.028407 | 1.547 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.028407 | 1.547 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.028407 | 1.547 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.028407 | 1.547 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.028407 | 1.547 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.028407 | 1.547 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.028407 | 1.547 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.028407 | 1.547 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.028407 | 1.547 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.028407 | 1.547 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.028407 | 1.547 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.017688 | 1.752 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.007959 | 2.099 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.019203 | 1.717 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.013395 | 1.873 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.007659 | 2.116 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.012216 | 1.913 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.031103 | 1.507 |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.028407 | 1.547 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.026755 | 1.573 |
R-HSA-1268020 | Mitochondrial protein import | 0.014462 | 1.840 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.008493 | 2.071 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.027932 | 1.554 |
R-HSA-3371556 | Cellular response to heat stress | 0.016854 | 1.773 |
R-HSA-9839394 | TGFBR3 expression | 0.021381 | 1.670 |
R-HSA-445355 | Smooth Muscle Contraction | 0.010025 | 1.999 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.013269 | 1.877 |
R-HSA-9629569 | Protein hydroxylation | 0.014299 | 1.845 |
R-HSA-1266695 | Interleukin-7 signaling | 0.021381 | 1.670 |
R-HSA-180292 | GAB1 signalosome | 0.012216 | 1.913 |
R-HSA-69275 | G2/M Transition | 0.016776 | 1.775 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.017415 | 1.759 |
R-HSA-525793 | Myogenesis | 0.022678 | 1.644 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.024006 | 1.620 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 0.016524 | 1.782 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.028175 | 1.550 |
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.020507 | 1.688 |
R-HSA-9755088 | Ribavirin ADME | 0.016524 | 1.782 |
R-HSA-373755 | Semaphorin interactions | 0.015014 | 1.824 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.027224 | 1.565 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.007629 | 2.118 |
R-HSA-75153 | Apoptotic execution phase | 0.007211 | 2.142 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.032611 | 1.487 |
R-HSA-176417 | Phosphorylation of Emi1 | 0.056013 | 1.252 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.056013 | 1.252 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.069524 | 1.158 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.069524 | 1.158 |
R-HSA-164843 | 2-LTR circle formation | 0.089430 | 1.049 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.095972 | 1.018 |
R-HSA-4839744 | Signaling by APC mutants | 0.095972 | 1.018 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.095972 | 1.018 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.095972 | 1.018 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.095972 | 1.018 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.102466 | 0.989 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.108915 | 0.963 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.108915 | 0.963 |
R-HSA-3000484 | Scavenging by Class F Receptors | 0.108915 | 0.963 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.108915 | 0.963 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.108915 | 0.963 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.108915 | 0.963 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.108915 | 0.963 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.127986 | 0.893 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.134253 | 0.872 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.134253 | 0.872 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.038919 | 1.410 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.146652 | 0.834 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.146652 | 0.834 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.146652 | 0.834 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.050955 | 1.293 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.170926 | 0.767 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.170926 | 0.767 |
R-HSA-429947 | Deadenylation of mRNA | 0.194515 | 0.711 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.082530 | 1.083 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.093366 | 1.030 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.093366 | 1.030 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.228656 | 0.641 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.097811 | 1.010 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.100055 | 1.000 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.234205 | 0.630 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.234205 | 0.630 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.245185 | 0.611 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.245185 | 0.611 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.250616 | 0.601 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.250616 | 0.601 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.250616 | 0.601 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.116153 | 0.935 |
R-HSA-380287 | Centrosome maturation | 0.120867 | 0.918 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.261362 | 0.583 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.261362 | 0.583 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.155053 | 0.810 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.206058 | 0.686 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.050764 | 1.294 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.050764 | 1.294 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.104587 | 0.981 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.160081 | 0.796 |
R-HSA-354192 | Integrin signaling | 0.245185 | 0.611 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.109174 | 0.962 |
R-HSA-191650 | Regulation of gap junction activity | 0.042309 | 1.374 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.217438 | 0.663 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.113814 | 0.944 |
R-HSA-4641265 | Repression of WNT target genes | 0.108915 | 0.963 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.070626 | 1.151 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.146652 | 0.834 |
R-HSA-418990 | Adherens junctions interactions | 0.093911 | 1.027 |
R-HSA-421270 | Cell-cell junction organization | 0.132777 | 0.877 |
R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.056013 | 1.252 |
R-HSA-446728 | Cell junction organization | 0.065063 | 1.187 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.145096 | 0.838 |
R-HSA-5205647 | Mitophagy | 0.256008 | 0.592 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.042309 | 1.374 |
R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.089430 | 1.049 |
R-HSA-192905 | vRNP Assembly | 0.095972 | 1.018 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.102466 | 0.989 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.102466 | 0.989 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.108915 | 0.963 |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.115317 | 0.938 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.042233 | 1.374 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.152786 | 0.816 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.182805 | 0.738 |
R-HSA-8949613 | Cristae formation | 0.211769 | 0.674 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.223067 | 0.652 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.234205 | 0.630 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.256008 | 0.592 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.214346 | 0.669 |
R-HSA-1500931 | Cell-Cell communication | 0.096320 | 1.016 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.228656 | 0.641 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.045648 | 1.341 |
R-HSA-3371511 | HSF1 activation | 0.038919 | 1.410 |
R-HSA-203615 | eNOS activation | 0.256008 | 0.592 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.228656 | 0.641 |
R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.121674 | 0.915 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.164922 | 0.783 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.250616 | 0.601 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.176886 | 0.752 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.102466 | 0.989 |
R-HSA-9615710 | Late endosomal microautophagy | 0.223067 | 0.652 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.228656 | 0.641 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.142628 | 0.846 |
R-HSA-68877 | Mitotic Prometaphase | 0.197203 | 0.705 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.194515 | 0.711 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.080413 | 1.095 |
R-HSA-6798695 | Neutrophil degranulation | 0.131941 | 0.880 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.211769 | 0.674 |
R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.211769 | 0.674 |
R-HSA-180746 | Nuclear import of Rev protein | 0.256008 | 0.592 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.196014 | 0.708 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.245185 | 0.611 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.152786 | 0.816 |
R-HSA-6794361 | Neurexins and neuroligins | 0.070095 | 1.154 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.179121 | 0.747 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.069524 | 1.158 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.068088 | 1.167 |
R-HSA-9663891 | Selective autophagy | 0.155053 | 0.810 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.223067 | 0.652 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.047393 | 1.324 |
R-HSA-9612973 | Autophagy | 0.037701 | 1.424 |
R-HSA-844456 | The NLRP3 inflammasome | 0.158876 | 0.799 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.040477 | 1.393 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.238136 | 0.623 |
R-HSA-162592 | Integration of provirus | 0.102466 | 0.989 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.040563 | 1.392 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.126573 | 0.898 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.056013 | 1.252 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.056013 | 1.252 |
R-HSA-9005895 | Pervasive developmental disorders | 0.108915 | 0.963 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.108915 | 0.963 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.108915 | 0.963 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.127986 | 0.893 |
R-HSA-3371568 | Attenuation phase | 0.045648 | 1.341 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.239715 | 0.620 |
R-HSA-9930044 | Nuclear RNA decay | 0.245185 | 0.611 |
R-HSA-5617833 | Cilium Assembly | 0.191730 | 0.717 |
R-HSA-449836 | Other interleukin signaling | 0.158876 | 0.799 |
R-HSA-1227986 | Signaling by ERBB2 | 0.086815 | 1.061 |
R-HSA-5689877 | Josephin domain DUBs | 0.089430 | 1.049 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.140475 | 0.852 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.152786 | 0.816 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.228656 | 0.641 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.113814 | 0.944 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.145096 | 0.838 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.176886 | 0.752 |
R-HSA-162909 | Host Interactions of HIV factors | 0.262059 | 0.582 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.176886 | 0.752 |
R-HSA-622312 | Inflammasomes | 0.217438 | 0.663 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.228656 | 0.641 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.131979 | 0.879 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.099990 | 1.000 |
R-HSA-9609507 | Protein localization | 0.126573 | 0.898 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.134253 | 0.872 |
R-HSA-175474 | Assembly Of The HIV Virion | 0.176886 | 0.752 |
R-HSA-166208 | mTORC1-mediated signalling | 0.182805 | 0.738 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.228656 | 0.641 |
R-HSA-1640170 | Cell Cycle | 0.156225 | 0.806 |
R-HSA-3214842 | HDMs demethylate histones | 0.200307 | 0.698 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.095581 | 1.020 |
R-HSA-68875 | Mitotic Prophase | 0.251417 | 0.600 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.109504 | 0.961 |
R-HSA-8876725 | Protein methylation | 0.127986 | 0.893 |
R-HSA-9748787 | Azathioprine ADME | 0.066100 | 1.180 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.239715 | 0.620 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.250616 | 0.601 |
R-HSA-73894 | DNA Repair | 0.140402 | 0.853 |
R-HSA-162587 | HIV Life Cycle | 0.038369 | 1.416 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.127986 | 0.893 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.091167 | 1.040 |
R-HSA-2262752 | Cellular responses to stress | 0.129207 | 0.889 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.245185 | 0.611 |
R-HSA-162906 | HIV Infection | 0.103903 | 0.983 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.058355 | 1.234 |
R-HSA-8953897 | Cellular responses to stimuli | 0.218964 | 0.660 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.111488 | 0.953 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 0.170926 | 0.767 |
R-HSA-397014 | Muscle contraction | 0.234571 | 0.630 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.105042 | 0.979 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.245185 | 0.611 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.111998 | 0.951 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.200307 | 0.698 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.109504 | 0.961 |
R-HSA-9007101 | Rab regulation of trafficking | 0.243445 | 0.614 |
R-HSA-4839726 | Chromatin organization | 0.130254 | 0.885 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.243445 | 0.614 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.076231 | 1.118 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.158876 | 0.799 |
R-HSA-211000 | Gene Silencing by RNA | 0.211716 | 0.674 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.054610 | 1.263 |
R-HSA-177929 | Signaling by EGFR | 0.078313 | 1.106 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.150057 | 0.824 |
R-HSA-5688426 | Deubiquitination | 0.137884 | 0.860 |
R-HSA-9758941 | Gastrulation | 0.120258 | 0.920 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.261442 | 0.583 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.175336 | 0.756 |
R-HSA-9006936 | Signaling by TGFB family members | 0.137903 | 0.860 |
R-HSA-2028269 | Signaling by Hippo | 0.146652 | 0.834 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.100603 | 0.997 |
R-HSA-5357801 | Programmed Cell Death | 0.080342 | 1.095 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.150057 | 0.824 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.066921 | 1.174 |
R-HSA-109581 | Apoptosis | 0.141203 | 0.850 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.165138 | 0.782 |
R-HSA-449147 | Signaling by Interleukins | 0.185355 | 0.732 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.043928 | 1.357 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.070095 | 1.154 |
R-HSA-194138 | Signaling by VEGF | 0.267382 | 0.573 |
R-HSA-162582 | Signal Transduction | 0.268770 | 0.571 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.271956 | 0.566 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.271956 | 0.566 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.271956 | 0.566 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.275816 | 0.559 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.277196 | 0.557 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.277196 | 0.557 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.277196 | 0.557 |
R-HSA-15869 | Metabolism of nucleotides | 0.280879 | 0.551 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.282399 | 0.549 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.282399 | 0.549 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.282399 | 0.549 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.282399 | 0.549 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.287564 | 0.541 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.287564 | 0.541 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.287564 | 0.541 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.287564 | 0.541 |
R-HSA-9646399 | Aggrephagy | 0.287564 | 0.541 |
R-HSA-157118 | Signaling by NOTCH | 0.288694 | 0.540 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.292693 | 0.534 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.292693 | 0.534 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.292693 | 0.534 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.292693 | 0.534 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.297785 | 0.526 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.297785 | 0.526 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.297785 | 0.526 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.301936 | 0.520 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.302841 | 0.519 |
R-HSA-165159 | MTOR signalling | 0.302841 | 0.519 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.307037 | 0.513 |
R-HSA-8854214 | TBC/RABGAPs | 0.307861 | 0.512 |
R-HSA-9609646 | HCMV Infection | 0.308302 | 0.511 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.309881 | 0.509 |
R-HSA-9664407 | Parasite infection | 0.312525 | 0.505 |
R-HSA-9664417 | Leishmania phagocytosis | 0.312525 | 0.505 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.312525 | 0.505 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.312845 | 0.505 |
R-HSA-373752 | Netrin-1 signaling | 0.312845 | 0.505 |
R-HSA-1632852 | Macroautophagy | 0.315168 | 0.501 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.317793 | 0.498 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.317793 | 0.498 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.317793 | 0.498 |
R-HSA-1489509 | DAG and IP3 signaling | 0.317793 | 0.498 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.322706 | 0.491 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.322706 | 0.491 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.322706 | 0.491 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.322706 | 0.491 |
R-HSA-6802949 | Signaling by RAS mutants | 0.322706 | 0.491 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.322706 | 0.491 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.322706 | 0.491 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.322706 | 0.491 |
R-HSA-68886 | M Phase | 0.330772 | 0.480 |
R-HSA-9031628 | NGF-stimulated transcription | 0.332427 | 0.478 |
R-HSA-9766229 | Degradation of CDH1 | 0.337235 | 0.472 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.337235 | 0.472 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.337235 | 0.472 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.341455 | 0.467 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.351456 | 0.454 |
R-HSA-199991 | Membrane Trafficking | 0.351649 | 0.454 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.354488 | 0.450 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.356128 | 0.448 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.356128 | 0.448 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.356128 | 0.448 |
R-HSA-168256 | Immune System | 0.358717 | 0.445 |
R-HSA-9610379 | HCMV Late Events | 0.359676 | 0.444 |
R-HSA-72649 | Translation initiation complex formation | 0.360767 | 0.443 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.360767 | 0.443 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.365279 | 0.437 |
R-HSA-418597 | G alpha (z) signalling events | 0.365373 | 0.437 |
R-HSA-3214815 | HDACs deacetylate histones | 0.365373 | 0.437 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.369194 | 0.433 |
R-HSA-9658195 | Leishmania infection | 0.369194 | 0.433 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.369947 | 0.432 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.369947 | 0.432 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.369947 | 0.432 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.374487 | 0.427 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.378995 | 0.421 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.378995 | 0.421 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.383471 | 0.416 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.383471 | 0.416 |
R-HSA-191859 | snRNP Assembly | 0.383471 | 0.416 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.383471 | 0.416 |
R-HSA-5619102 | SLC transporter disorders | 0.385382 | 0.414 |
R-HSA-422475 | Axon guidance | 0.386504 | 0.413 |
R-HSA-983189 | Kinesins | 0.387915 | 0.411 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.387915 | 0.411 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.387915 | 0.411 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.387915 | 0.411 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.387915 | 0.411 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.387915 | 0.411 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.387915 | 0.411 |
R-HSA-5653656 | Vesicle-mediated transport | 0.389010 | 0.410 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.392327 | 0.406 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.396707 | 0.402 |
R-HSA-9707616 | Heme signaling | 0.396707 | 0.402 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.396707 | 0.402 |
R-HSA-8848021 | Signaling by PTK6 | 0.401057 | 0.397 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.401057 | 0.397 |
R-HSA-195721 | Signaling by WNT | 0.402273 | 0.395 |
R-HSA-5689880 | Ub-specific processing proteases | 0.403113 | 0.395 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.405375 | 0.392 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.413919 | 0.383 |
R-HSA-168255 | Influenza Infection | 0.418121 | 0.379 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.418145 | 0.379 |
R-HSA-8953854 | Metabolism of RNA | 0.421088 | 0.376 |
R-HSA-5218859 | Regulated Necrosis | 0.422341 | 0.374 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.430643 | 0.366 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.434750 | 0.362 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.434750 | 0.362 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.434750 | 0.362 |
R-HSA-8978934 | Metabolism of cofactors | 0.434750 | 0.362 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.438827 | 0.358 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.438827 | 0.358 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.438827 | 0.358 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.438827 | 0.358 |
R-HSA-9675108 | Nervous system development | 0.439266 | 0.357 |
R-HSA-983712 | Ion channel transport | 0.442708 | 0.354 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.442875 | 0.354 |
R-HSA-4086398 | Ca2+ pathway | 0.442875 | 0.354 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.442875 | 0.354 |
R-HSA-9824446 | Viral Infection Pathways | 0.446402 | 0.350 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.446894 | 0.350 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.446894 | 0.350 |
R-HSA-1236394 | Signaling by ERBB4 | 0.446894 | 0.350 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.446894 | 0.350 |
R-HSA-1266738 | Developmental Biology | 0.449401 | 0.347 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.450885 | 0.346 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.454789 | 0.342 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.454847 | 0.342 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.458780 | 0.338 |
R-HSA-9609690 | HCMV Early Events | 0.459580 | 0.338 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.462686 | 0.335 |
R-HSA-216083 | Integrin cell surface interactions | 0.462686 | 0.335 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.470413 | 0.328 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.470413 | 0.328 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.474235 | 0.324 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.474235 | 0.324 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.478030 | 0.321 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.478030 | 0.321 |
R-HSA-72172 | mRNA Splicing | 0.480836 | 0.318 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.481798 | 0.317 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.485538 | 0.314 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.485538 | 0.314 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.492940 | 0.307 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.492940 | 0.307 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.492940 | 0.307 |
R-HSA-70268 | Pyruvate metabolism | 0.500235 | 0.301 |
R-HSA-68882 | Mitotic Anaphase | 0.508377 | 0.294 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.510629 | 0.292 |
R-HSA-168249 | Innate Immune System | 0.511289 | 0.291 |
R-HSA-9748784 | Drug ADME | 0.512875 | 0.290 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.514516 | 0.289 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.521504 | 0.283 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.522917 | 0.282 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.524960 | 0.280 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.528392 | 0.277 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.535734 | 0.271 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.538540 | 0.269 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.538540 | 0.269 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.541875 | 0.266 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.541875 | 0.266 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.551735 | 0.258 |
R-HSA-70171 | Glycolysis | 0.551735 | 0.258 |
R-HSA-8939211 | ESR-mediated signaling | 0.554253 | 0.256 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.554975 | 0.256 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.564556 | 0.248 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.564556 | 0.248 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.567704 | 0.246 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.567704 | 0.246 |
R-HSA-9833110 | RSV-host interactions | 0.567704 | 0.246 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.570766 | 0.244 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.570830 | 0.243 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.575025 | 0.240 |
R-HSA-69239 | Synthesis of DNA | 0.577013 | 0.239 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.577013 | 0.239 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.577013 | 0.239 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.580072 | 0.237 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.580072 | 0.237 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.583109 | 0.234 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.583109 | 0.234 |
R-HSA-5663205 | Infectious disease | 0.584255 | 0.233 |
R-HSA-202403 | TCR signaling | 0.586124 | 0.232 |
R-HSA-6803157 | Antimicrobial peptides | 0.589117 | 0.230 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.592089 | 0.228 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.597060 | 0.224 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.597969 | 0.223 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.597969 | 0.223 |
R-HSA-9679506 | SARS-CoV Infections | 0.599077 | 0.223 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.606632 | 0.217 |
R-HSA-9734767 | Developmental Cell Lineages | 0.606792 | 0.217 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.609478 | 0.215 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.609478 | 0.215 |
R-HSA-70326 | Glucose metabolism | 0.612304 | 0.213 |
R-HSA-2980736 | Peptide hormone metabolism | 0.612304 | 0.213 |
R-HSA-5693538 | Homology Directed Repair | 0.615110 | 0.211 |
R-HSA-9711123 | Cellular response to chemical stress | 0.616348 | 0.210 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.623407 | 0.205 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.627581 | 0.202 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.628839 | 0.201 |
R-HSA-2132295 | MHC class II antigen presentation | 0.628839 | 0.201 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.636842 | 0.196 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
R-HSA-114608 | Platelet degranulation | 0.642082 | 0.192 |
R-HSA-69481 | G2/M Checkpoints | 0.642082 | 0.192 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.644674 | 0.191 |
R-HSA-9843745 | Adipogenesis | 0.654857 | 0.184 |
R-HSA-9909396 | Circadian clock | 0.657357 | 0.182 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.657357 | 0.182 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.657357 | 0.182 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.659839 | 0.181 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.669591 | 0.174 |
R-HSA-1643685 | Disease | 0.684546 | 0.165 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.688271 | 0.162 |
R-HSA-69242 | S Phase | 0.699410 | 0.155 |
R-HSA-166520 | Signaling by NTRKs | 0.699410 | 0.155 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.703754 | 0.153 |
R-HSA-69306 | DNA Replication | 0.710155 | 0.149 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.712257 | 0.147 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.712257 | 0.147 |
R-HSA-1989781 | PPARA activates gene expression | 0.714345 | 0.146 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.718475 | 0.144 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.732470 | 0.135 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.736209 | 0.133 |
R-HSA-72306 | tRNA processing | 0.745776 | 0.127 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.749455 | 0.125 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.754876 | 0.122 |
R-HSA-611105 | Respiratory electron transport | 0.760180 | 0.119 |
R-HSA-2559583 | Cellular Senescence | 0.763653 | 0.117 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.795752 | 0.099 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.795752 | 0.099 |
R-HSA-428157 | Sphingolipid metabolism | 0.797238 | 0.098 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.835972 | 0.078 |
R-HSA-382551 | Transport of small molecules | 0.854460 | 0.068 |
R-HSA-74160 | Gene expression (Transcription) | 0.862344 | 0.064 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.865399 | 0.063 |
R-HSA-597592 | Post-translational protein modification | 0.865603 | 0.063 |
R-HSA-112316 | Neuronal System | 0.870488 | 0.060 |
R-HSA-416476 | G alpha (q) signalling events | 0.873066 | 0.059 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.880752 | 0.055 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.885456 | 0.053 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.888770 | 0.051 |
R-HSA-1280218 | Adaptive Immune System | 0.889228 | 0.051 |
R-HSA-212436 | Generic Transcription Pathway | 0.889353 | 0.051 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.894343 | 0.048 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.899639 | 0.046 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.917713 | 0.037 |
R-HSA-1474244 | Extracellular matrix organization | 0.922419 | 0.035 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.928458 | 0.032 |
R-HSA-5683057 | MAPK family signaling cascades | 0.931047 | 0.031 |
R-HSA-109582 | Hemostasis | 0.933286 | 0.030 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.939172 | 0.027 |
R-HSA-392499 | Metabolism of proteins | 0.946442 | 0.024 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.947524 | 0.023 |
R-HSA-913531 | Interferon Signaling | 0.947524 | 0.023 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.952683 | 0.021 |
R-HSA-72766 | Translation | 0.962664 | 0.017 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.969212 | 0.014 |
R-HSA-211859 | Biological oxidations | 0.981435 | 0.008 |
R-HSA-388396 | GPCR downstream signalling | 0.997186 | 0.001 |
R-HSA-372790 | Signaling by GPCR | 0.998502 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 0.999857 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999991 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.788 | 0.128 | 2 | 0.870 |
CLK3 |
0.774 | 0.082 | 1 | 0.677 |
DSTYK |
0.772 | 0.070 | 2 | 0.868 |
KIS |
0.770 | 0.058 | 1 | 0.546 |
IKKB |
0.770 | 0.053 | -2 | 0.712 |
CDC7 |
0.769 | 0.034 | 1 | 0.627 |
CAMK2G |
0.768 | 0.084 | 2 | 0.796 |
IKKA |
0.768 | 0.087 | -2 | 0.712 |
GRK1 |
0.768 | 0.108 | -2 | 0.763 |
MOS |
0.768 | 0.065 | 1 | 0.665 |
MTOR |
0.767 | 0.074 | 1 | 0.632 |
GRK6 |
0.766 | 0.105 | 1 | 0.619 |
IKKE |
0.765 | 0.060 | 1 | 0.639 |
TBK1 |
0.764 | 0.030 | 1 | 0.631 |
RAF1 |
0.763 | 0.009 | 1 | 0.688 |
GRK4 |
0.762 | 0.073 | -2 | 0.812 |
FAM20C |
0.762 | 0.046 | 2 | 0.565 |
ATR |
0.762 | 0.036 | 1 | 0.658 |
GRK7 |
0.761 | 0.122 | 1 | 0.557 |
GRK5 |
0.760 | 0.023 | -3 | 0.797 |
PRPK |
0.760 | -0.105 | -1 | 0.792 |
GCN2 |
0.760 | -0.085 | 2 | 0.774 |
PIM3 |
0.760 | -0.004 | -3 | 0.719 |
PDHK4 |
0.759 | -0.039 | 1 | 0.690 |
NEK7 |
0.758 | -0.028 | -3 | 0.746 |
BMPR2 |
0.758 | -0.049 | -2 | 0.849 |
BMPR1B |
0.757 | 0.084 | 1 | 0.566 |
CAMK1B |
0.755 | -0.029 | -3 | 0.764 |
NDR2 |
0.755 | -0.025 | -3 | 0.719 |
NEK6 |
0.754 | -0.037 | -2 | 0.863 |
MLK1 |
0.754 | -0.028 | 2 | 0.786 |
RIPK3 |
0.753 | -0.060 | 3 | 0.385 |
NLK |
0.753 | -0.034 | 1 | 0.654 |
GSK3A |
0.752 | 0.162 | 4 | 0.502 |
ULK2 |
0.752 | -0.110 | 2 | 0.748 |
ATM |
0.752 | 0.001 | 1 | 0.606 |
CDK1 |
0.751 | 0.042 | 1 | 0.473 |
PLK1 |
0.751 | 0.044 | -2 | 0.833 |
PDHK1 |
0.751 | -0.076 | 1 | 0.711 |
CAMK2B |
0.751 | 0.063 | 2 | 0.776 |
MST4 |
0.750 | -0.008 | 2 | 0.847 |
CHAK2 |
0.750 | -0.033 | -1 | 0.809 |
TLK2 |
0.750 | 0.075 | 1 | 0.657 |
PIM1 |
0.750 | 0.004 | -3 | 0.672 |
PLK3 |
0.749 | 0.068 | 2 | 0.753 |
SRPK1 |
0.749 | -0.018 | -3 | 0.631 |
WNK1 |
0.749 | -0.029 | -2 | 0.817 |
RSK2 |
0.749 | 0.011 | -3 | 0.653 |
SKMLCK |
0.748 | -0.026 | -2 | 0.791 |
HUNK |
0.748 | -0.111 | 2 | 0.824 |
DLK |
0.748 | 0.030 | 1 | 0.645 |
ERK5 |
0.748 | -0.060 | 1 | 0.627 |
BMPR1A |
0.747 | 0.077 | 1 | 0.558 |
CK2A2 |
0.747 | 0.066 | 1 | 0.476 |
NIK |
0.746 | -0.082 | -3 | 0.784 |
ACVR2B |
0.746 | 0.052 | -2 | 0.776 |
SMG1 |
0.746 | 0.051 | 1 | 0.636 |
PKN3 |
0.746 | -0.064 | -3 | 0.711 |
MARK4 |
0.746 | -0.062 | 4 | 0.769 |
CDKL1 |
0.745 | -0.057 | -3 | 0.686 |
CAMK2D |
0.745 | -0.000 | -3 | 0.708 |
TGFBR2 |
0.745 | -0.055 | -2 | 0.779 |
NUAK2 |
0.744 | -0.060 | -3 | 0.733 |
GSK3B |
0.744 | 0.134 | 4 | 0.496 |
CK1G1 |
0.744 | 0.066 | -3 | 0.561 |
CAMK2A |
0.744 | 0.057 | 2 | 0.793 |
TGFBR1 |
0.744 | 0.011 | -2 | 0.762 |
ANKRD3 |
0.744 | -0.044 | 1 | 0.685 |
ULK1 |
0.744 | -0.101 | -3 | 0.752 |
PLK2 |
0.744 | 0.149 | -3 | 0.836 |
TTBK2 |
0.744 | -0.048 | 2 | 0.687 |
YSK4 |
0.743 | 0.048 | 1 | 0.640 |
JNK3 |
0.743 | 0.020 | 1 | 0.506 |
DNAPK |
0.743 | 0.070 | 1 | 0.604 |
NDR1 |
0.743 | -0.064 | -3 | 0.717 |
ALK4 |
0.743 | -0.004 | -2 | 0.784 |
ALK2 |
0.743 | 0.035 | -2 | 0.778 |
CAMLCK |
0.743 | -0.073 | -2 | 0.780 |
WNK3 |
0.742 | -0.122 | 1 | 0.676 |
CDK8 |
0.742 | -0.024 | 1 | 0.542 |
NEK9 |
0.742 | -0.094 | 2 | 0.811 |
ACVR2A |
0.742 | 0.022 | -2 | 0.762 |
HIPK4 |
0.742 | -0.048 | 1 | 0.643 |
PKR |
0.742 | -0.008 | 1 | 0.694 |
MASTL |
0.742 | -0.130 | -2 | 0.792 |
JNK2 |
0.741 | 0.028 | 1 | 0.472 |
BCKDK |
0.741 | -0.080 | -1 | 0.693 |
PKN2 |
0.741 | -0.049 | -3 | 0.725 |
SRPK2 |
0.740 | -0.018 | -3 | 0.559 |
PKCD |
0.740 | -0.040 | 2 | 0.761 |
SRPK3 |
0.740 | -0.027 | -3 | 0.612 |
AMPKA1 |
0.739 | -0.077 | -3 | 0.737 |
PRKD1 |
0.739 | -0.058 | -3 | 0.670 |
P90RSK |
0.739 | -0.037 | -3 | 0.656 |
MLK4 |
0.739 | -0.020 | 2 | 0.694 |
PKACG |
0.739 | -0.026 | -2 | 0.694 |
PRKD2 |
0.739 | -0.025 | -3 | 0.636 |
LATS1 |
0.739 | 0.013 | -3 | 0.738 |
MLK3 |
0.739 | -0.044 | 2 | 0.715 |
CK1E |
0.739 | 0.036 | -3 | 0.551 |
LATS2 |
0.738 | -0.044 | -5 | 0.643 |
TSSK2 |
0.738 | -0.064 | -5 | 0.715 |
NIM1 |
0.738 | -0.082 | 3 | 0.404 |
DAPK2 |
0.738 | -0.098 | -3 | 0.758 |
TSSK1 |
0.737 | -0.042 | -3 | 0.755 |
MLK2 |
0.737 | -0.111 | 2 | 0.785 |
RSK3 |
0.737 | -0.033 | -3 | 0.648 |
CK2A1 |
0.737 | 0.056 | 1 | 0.450 |
MEK1 |
0.737 | -0.047 | 2 | 0.816 |
GAK |
0.737 | 0.156 | 1 | 0.698 |
RIPK1 |
0.737 | -0.133 | 1 | 0.645 |
MEKK3 |
0.737 | 0.015 | 1 | 0.629 |
PASK |
0.737 | 0.107 | -3 | 0.728 |
CDK2 |
0.736 | -0.013 | 1 | 0.529 |
CLK2 |
0.736 | 0.024 | -3 | 0.646 |
GRK2 |
0.736 | -0.009 | -2 | 0.686 |
CK1D |
0.736 | 0.054 | -3 | 0.500 |
ICK |
0.735 | -0.062 | -3 | 0.712 |
P70S6KB |
0.735 | -0.058 | -3 | 0.686 |
CK1A2 |
0.735 | 0.058 | -3 | 0.499 |
CDKL5 |
0.734 | -0.071 | -3 | 0.670 |
P38D |
0.734 | 0.025 | 1 | 0.464 |
IRE1 |
0.734 | -0.126 | 1 | 0.661 |
VRK2 |
0.734 | -0.122 | 1 | 0.705 |
CDK19 |
0.733 | -0.037 | 1 | 0.512 |
P38B |
0.733 | 0.012 | 1 | 0.485 |
JNK1 |
0.733 | 0.028 | 1 | 0.456 |
TLK1 |
0.733 | -0.014 | -2 | 0.810 |
NUAK1 |
0.733 | -0.056 | -3 | 0.681 |
MAPKAPK2 |
0.732 | -0.045 | -3 | 0.597 |
PLK4 |
0.732 | -0.031 | 2 | 0.601 |
DYRK2 |
0.732 | -0.038 | 1 | 0.553 |
CDK3 |
0.732 | -0.003 | 1 | 0.434 |
CLK4 |
0.732 | -0.021 | -3 | 0.666 |
AMPKA2 |
0.732 | -0.084 | -3 | 0.701 |
P38G |
0.731 | -0.000 | 1 | 0.410 |
CDK5 |
0.731 | -0.032 | 1 | 0.545 |
AURC |
0.731 | -0.024 | -2 | 0.584 |
RSK4 |
0.731 | -0.005 | -3 | 0.622 |
PRKX |
0.731 | 0.021 | -3 | 0.567 |
MSK1 |
0.730 | -0.007 | -3 | 0.617 |
MARK2 |
0.730 | -0.048 | 4 | 0.706 |
GRK3 |
0.730 | 0.007 | -2 | 0.649 |
PRP4 |
0.730 | 0.016 | -3 | 0.710 |
P38A |
0.730 | -0.018 | 1 | 0.551 |
CDK13 |
0.730 | -0.046 | 1 | 0.509 |
QSK |
0.729 | -0.069 | 4 | 0.741 |
IRE2 |
0.729 | -0.120 | 2 | 0.699 |
MEKK2 |
0.729 | -0.022 | 2 | 0.769 |
ERK1 |
0.728 | -0.019 | 1 | 0.487 |
MSK2 |
0.728 | -0.063 | -3 | 0.608 |
BRAF |
0.728 | -0.045 | -4 | 0.702 |
CLK1 |
0.728 | -0.021 | -3 | 0.638 |
PINK1 |
0.728 | -0.094 | 1 | 0.689 |
PKCB |
0.727 | -0.055 | 2 | 0.713 |
MARK3 |
0.727 | -0.052 | 4 | 0.715 |
MAPKAPK3 |
0.727 | -0.102 | -3 | 0.635 |
CHAK1 |
0.727 | -0.113 | 2 | 0.705 |
PAK1 |
0.727 | -0.067 | -2 | 0.686 |
PKACB |
0.727 | -0.017 | -2 | 0.612 |
CAMK4 |
0.727 | -0.110 | -3 | 0.710 |
TAO3 |
0.726 | 0.012 | 1 | 0.635 |
CDK18 |
0.726 | -0.021 | 1 | 0.475 |
AURA |
0.725 | -0.017 | -2 | 0.559 |
NEK5 |
0.725 | -0.060 | 1 | 0.682 |
SIK |
0.725 | -0.076 | -3 | 0.644 |
NEK2 |
0.725 | -0.103 | 2 | 0.769 |
PKCZ |
0.725 | -0.084 | 2 | 0.741 |
MEKK1 |
0.725 | -0.095 | 1 | 0.669 |
ERK2 |
0.724 | -0.041 | 1 | 0.519 |
MYLK4 |
0.724 | -0.062 | -2 | 0.691 |
MST3 |
0.724 | 0.004 | 2 | 0.823 |
ZAK |
0.723 | -0.054 | 1 | 0.641 |
PKCA |
0.723 | -0.059 | 2 | 0.699 |
PAK6 |
0.723 | -0.014 | -2 | 0.604 |
QIK |
0.723 | -0.136 | -3 | 0.712 |
PERK |
0.723 | -0.126 | -2 | 0.815 |
AURB |
0.723 | -0.044 | -2 | 0.585 |
CDK7 |
0.722 | -0.069 | 1 | 0.530 |
CDK17 |
0.722 | -0.023 | 1 | 0.416 |
PKCG |
0.722 | -0.079 | 2 | 0.708 |
CAMK1G |
0.722 | -0.065 | -3 | 0.647 |
HIPK2 |
0.721 | -0.027 | 1 | 0.484 |
DRAK1 |
0.721 | -0.094 | 1 | 0.504 |
MST2 |
0.721 | 0.045 | 1 | 0.654 |
MEK5 |
0.721 | -0.150 | 2 | 0.789 |
MELK |
0.721 | -0.120 | -3 | 0.680 |
MNK2 |
0.721 | -0.077 | -2 | 0.730 |
CHK1 |
0.721 | -0.086 | -3 | 0.717 |
PAK3 |
0.720 | -0.113 | -2 | 0.687 |
CDK12 |
0.720 | -0.051 | 1 | 0.483 |
PRKD3 |
0.720 | -0.074 | -3 | 0.615 |
PKCH |
0.720 | -0.083 | 2 | 0.686 |
MARK1 |
0.720 | -0.084 | 4 | 0.722 |
PAK2 |
0.719 | -0.103 | -2 | 0.673 |
CDK9 |
0.719 | -0.069 | 1 | 0.519 |
DYRK4 |
0.719 | -0.020 | 1 | 0.489 |
DCAMKL1 |
0.718 | -0.062 | -3 | 0.667 |
AKT2 |
0.718 | -0.045 | -3 | 0.576 |
TTBK1 |
0.717 | -0.071 | 2 | 0.603 |
TAK1 |
0.717 | 0.080 | 1 | 0.678 |
WNK4 |
0.717 | -0.117 | -2 | 0.816 |
HRI |
0.717 | -0.168 | -2 | 0.815 |
GCK |
0.717 | 0.076 | 1 | 0.647 |
MNK1 |
0.717 | -0.080 | -2 | 0.742 |
PKG2 |
0.717 | -0.049 | -2 | 0.615 |
SGK3 |
0.716 | -0.058 | -3 | 0.631 |
NEK11 |
0.715 | -0.044 | 1 | 0.626 |
CAMKK1 |
0.715 | -0.096 | -2 | 0.724 |
HIPK1 |
0.715 | -0.054 | 1 | 0.576 |
NEK8 |
0.715 | -0.107 | 2 | 0.774 |
MAPKAPK5 |
0.715 | -0.117 | -3 | 0.578 |
PIM2 |
0.715 | -0.065 | -3 | 0.630 |
IRAK4 |
0.714 | -0.138 | 1 | 0.682 |
PHKG1 |
0.714 | -0.128 | -3 | 0.702 |
MINK |
0.713 | 0.017 | 1 | 0.679 |
CK1A |
0.713 | 0.053 | -3 | 0.427 |
EEF2K |
0.713 | -0.047 | 3 | 0.466 |
SSTK |
0.712 | -0.080 | 4 | 0.733 |
CDK16 |
0.712 | -0.022 | 1 | 0.438 |
MPSK1 |
0.712 | -0.061 | 1 | 0.680 |
BRSK1 |
0.712 | -0.132 | -3 | 0.667 |
TNIK |
0.711 | -0.022 | 3 | 0.453 |
MST1 |
0.710 | 0.021 | 1 | 0.656 |
PKACA |
0.710 | -0.028 | -2 | 0.556 |
DYRK1A |
0.710 | -0.074 | 1 | 0.582 |
DCAMKL2 |
0.710 | -0.066 | -3 | 0.699 |
SNRK |
0.710 | -0.201 | 2 | 0.621 |
HGK |
0.709 | -0.032 | 3 | 0.462 |
IRAK1 |
0.709 | -0.169 | -1 | 0.681 |
LKB1 |
0.709 | -0.098 | -3 | 0.723 |
BRSK2 |
0.709 | -0.148 | -3 | 0.691 |
TAO2 |
0.709 | -0.096 | 2 | 0.818 |
PDK1 |
0.709 | -0.087 | 1 | 0.639 |
SMMLCK |
0.709 | -0.095 | -3 | 0.702 |
CK1G3 |
0.709 | 0.089 | -3 | 0.383 |
CDK14 |
0.709 | -0.050 | 1 | 0.509 |
HPK1 |
0.709 | 0.043 | 1 | 0.642 |
CAMKK2 |
0.709 | -0.091 | -2 | 0.712 |
STK33 |
0.707 | -0.058 | 2 | 0.588 |
NEK4 |
0.707 | -0.091 | 1 | 0.674 |
P70S6K |
0.706 | -0.078 | -3 | 0.586 |
KHS2 |
0.706 | 0.040 | 1 | 0.673 |
CDK10 |
0.706 | -0.035 | 1 | 0.494 |
DYRK3 |
0.705 | -0.067 | 1 | 0.580 |
SLK |
0.705 | -0.017 | -2 | 0.690 |
TTK |
0.705 | 0.030 | -2 | 0.827 |
VRK1 |
0.705 | -0.095 | 2 | 0.827 |
AKT1 |
0.705 | -0.056 | -3 | 0.584 |
PAK4 |
0.704 | -0.038 | -2 | 0.551 |
ALPHAK3 |
0.704 | 0.039 | -1 | 0.720 |
DAPK3 |
0.704 | -0.066 | -3 | 0.686 |
DYRK1B |
0.704 | -0.070 | 1 | 0.506 |
PAK5 |
0.703 | -0.053 | -2 | 0.542 |
KHS1 |
0.703 | 0.020 | 1 | 0.674 |
CAMK1D |
0.703 | -0.074 | -3 | 0.561 |
PKCT |
0.703 | -0.115 | 2 | 0.697 |
ERK7 |
0.702 | -0.049 | 2 | 0.503 |
LRRK2 |
0.701 | -0.116 | 2 | 0.805 |
DAPK1 |
0.701 | -0.055 | -3 | 0.669 |
LOK |
0.701 | -0.062 | -2 | 0.741 |
PKCI |
0.700 | -0.105 | 2 | 0.708 |
HIPK3 |
0.700 | -0.101 | 1 | 0.562 |
YANK3 |
0.700 | 0.013 | 2 | 0.400 |
PHKG2 |
0.700 | -0.124 | -3 | 0.695 |
CDK6 |
0.699 | -0.059 | 1 | 0.502 |
MRCKA |
0.699 | -0.030 | -3 | 0.639 |
PKCE |
0.699 | -0.070 | 2 | 0.691 |
NEK1 |
0.698 | -0.128 | 1 | 0.663 |
CK1G2 |
0.698 | 0.081 | -3 | 0.477 |
OSR1 |
0.698 | -0.024 | 2 | 0.773 |
MAP3K15 |
0.698 | -0.107 | 1 | 0.629 |
MEKK6 |
0.697 | -0.127 | 1 | 0.653 |
MRCKB |
0.696 | -0.043 | -3 | 0.623 |
ROCK2 |
0.695 | -0.044 | -3 | 0.666 |
PBK |
0.695 | -0.025 | 1 | 0.661 |
PDHK3_TYR |
0.694 | 0.062 | 4 | 0.787 |
CDK4 |
0.694 | -0.068 | 1 | 0.480 |
PDHK4_TYR |
0.694 | 0.101 | 2 | 0.846 |
SGK1 |
0.694 | -0.043 | -3 | 0.491 |
BMPR2_TYR |
0.693 | 0.102 | -1 | 0.808 |
MEK2 |
0.693 | -0.170 | 2 | 0.778 |
YSK1 |
0.692 | -0.096 | 2 | 0.779 |
MAP2K6_TYR |
0.692 | 0.067 | -1 | 0.811 |
RIPK2 |
0.692 | -0.189 | 1 | 0.596 |
AKT3 |
0.690 | -0.052 | -3 | 0.500 |
PDHK1_TYR |
0.689 | 0.062 | -1 | 0.826 |
CHK2 |
0.689 | -0.077 | -3 | 0.520 |
DMPK1 |
0.688 | -0.030 | -3 | 0.652 |
CAMK1A |
0.688 | -0.079 | -3 | 0.533 |
MAK |
0.688 | -0.041 | -2 | 0.633 |
MAP2K4_TYR |
0.687 | -0.015 | -1 | 0.803 |
HASPIN |
0.686 | -0.055 | -1 | 0.636 |
PKN1 |
0.685 | -0.112 | -3 | 0.599 |
BIKE |
0.685 | -0.002 | 1 | 0.632 |
BUB1 |
0.685 | -0.069 | -5 | 0.687 |
MYO3A |
0.684 | -0.049 | 1 | 0.661 |
SBK |
0.683 | -0.061 | -3 | 0.456 |
MAP2K7_TYR |
0.682 | -0.138 | 2 | 0.823 |
PKG1 |
0.682 | -0.064 | -2 | 0.530 |
NEK3 |
0.681 | -0.172 | 1 | 0.647 |
MYO3B |
0.681 | -0.085 | 2 | 0.777 |
ROCK1 |
0.680 | -0.062 | -3 | 0.637 |
CRIK |
0.679 | -0.043 | -3 | 0.573 |
MOK |
0.679 | -0.090 | 1 | 0.584 |
TESK1_TYR |
0.679 | -0.175 | 3 | 0.484 |
YANK2 |
0.677 | 0.017 | 2 | 0.408 |
PKMYT1_TYR |
0.677 | -0.155 | 3 | 0.453 |
PINK1_TYR |
0.676 | -0.195 | 1 | 0.650 |
STLK3 |
0.676 | -0.080 | 1 | 0.607 |
YES1 |
0.675 | -0.035 | -1 | 0.787 |
ASK1 |
0.675 | -0.146 | 1 | 0.620 |
EPHA6 |
0.674 | -0.055 | -1 | 0.794 |
FGR |
0.674 | -0.039 | 1 | 0.652 |
FYN |
0.673 | 0.042 | -1 | 0.761 |
TXK |
0.673 | -0.005 | 1 | 0.589 |
BLK |
0.672 | -0.008 | -1 | 0.796 |
TAO1 |
0.672 | -0.134 | 1 | 0.605 |
FER |
0.671 | -0.073 | 1 | 0.658 |
EPHA4 |
0.671 | -0.024 | 2 | 0.764 |
RET |
0.671 | -0.149 | 1 | 0.655 |
EPHB4 |
0.671 | -0.086 | -1 | 0.763 |
LCK |
0.669 | -0.032 | -1 | 0.787 |
HCK |
0.669 | -0.073 | -1 | 0.782 |
INSRR |
0.668 | -0.110 | 3 | 0.375 |
SRMS |
0.668 | -0.062 | 1 | 0.624 |
CSF1R |
0.668 | -0.124 | 3 | 0.360 |
DDR1 |
0.668 | -0.128 | 4 | 0.730 |
MST1R |
0.668 | -0.183 | 3 | 0.383 |
AAK1 |
0.667 | 0.014 | 1 | 0.565 |
LIMK2_TYR |
0.667 | -0.184 | -3 | 0.778 |
EPHB2 |
0.666 | -0.048 | -1 | 0.749 |
TYK2 |
0.666 | -0.214 | 1 | 0.667 |
ABL2 |
0.666 | -0.109 | -1 | 0.765 |
KIT |
0.666 | -0.100 | 3 | 0.383 |
TYRO3 |
0.666 | -0.184 | 3 | 0.379 |
ITK |
0.665 | -0.058 | -1 | 0.749 |
JAK2 |
0.665 | -0.182 | 1 | 0.666 |
EPHB1 |
0.665 | -0.086 | 1 | 0.625 |
FLT1 |
0.665 | -0.024 | -1 | 0.761 |
FGFR2 |
0.664 | -0.106 | 3 | 0.441 |
ABL1 |
0.664 | -0.096 | -1 | 0.756 |
ROS1 |
0.663 | -0.194 | 3 | 0.352 |
JAK3 |
0.663 | -0.139 | 1 | 0.624 |
FLT3 |
0.663 | -0.132 | 3 | 0.376 |
LIMK1_TYR |
0.662 | -0.259 | 2 | 0.808 |
TNK2 |
0.662 | -0.131 | 3 | 0.361 |
MET |
0.662 | -0.091 | 3 | 0.368 |
KDR |
0.662 | -0.122 | 3 | 0.360 |
SRC |
0.661 | -0.019 | -1 | 0.752 |
LYN |
0.661 | -0.052 | 3 | 0.338 |
SYK |
0.661 | 0.044 | -1 | 0.720 |
EPHB3 |
0.660 | -0.115 | -1 | 0.746 |
BMX |
0.660 | -0.061 | -1 | 0.694 |
PTK2 |
0.660 | 0.018 | -1 | 0.731 |
FGFR3 |
0.660 | -0.082 | 3 | 0.421 |
ERBB2 |
0.660 | -0.090 | 1 | 0.599 |
NEK10_TYR |
0.659 | -0.102 | 1 | 0.581 |
TEC |
0.657 | -0.082 | -1 | 0.694 |
TEK |
0.657 | -0.163 | 3 | 0.361 |
EPHA3 |
0.656 | -0.091 | 2 | 0.732 |
EGFR |
0.656 | -0.030 | 1 | 0.506 |
PTK6 |
0.656 | -0.106 | -1 | 0.659 |
EPHA7 |
0.656 | -0.079 | 2 | 0.756 |
FGFR1 |
0.656 | -0.172 | 3 | 0.378 |
BTK |
0.655 | -0.125 | -1 | 0.716 |
PDGFRB |
0.655 | -0.179 | 3 | 0.382 |
MERTK |
0.655 | -0.123 | 3 | 0.374 |
FGFR4 |
0.655 | -0.031 | -1 | 0.702 |
FRK |
0.655 | -0.090 | -1 | 0.804 |
EPHA5 |
0.654 | -0.067 | 2 | 0.743 |
NTRK1 |
0.652 | -0.162 | -1 | 0.730 |
FLT4 |
0.652 | -0.136 | 3 | 0.385 |
AXL |
0.652 | -0.169 | 3 | 0.378 |
CSK |
0.650 | -0.084 | 2 | 0.758 |
EPHA8 |
0.650 | -0.078 | -1 | 0.739 |
TNK1 |
0.650 | -0.185 | 3 | 0.364 |
JAK1 |
0.650 | -0.138 | 1 | 0.624 |
TNNI3K_TYR |
0.649 | -0.126 | 1 | 0.695 |
WEE1_TYR |
0.649 | -0.129 | -1 | 0.675 |
LTK |
0.649 | -0.160 | 3 | 0.347 |
MATK |
0.649 | -0.105 | -1 | 0.694 |
ERBB4 |
0.648 | -0.037 | 1 | 0.503 |
NTRK2 |
0.648 | -0.173 | 3 | 0.366 |
DDR2 |
0.648 | -0.096 | 3 | 0.381 |
INSR |
0.647 | -0.164 | 3 | 0.350 |
ALK |
0.647 | -0.186 | 3 | 0.326 |
PDGFRA |
0.646 | -0.239 | 3 | 0.370 |
PTK2B |
0.646 | -0.104 | -1 | 0.722 |
EPHA2 |
0.645 | -0.064 | -1 | 0.709 |
NTRK3 |
0.645 | -0.143 | -1 | 0.684 |
EPHA1 |
0.641 | -0.177 | 3 | 0.349 |
IGF1R |
0.641 | -0.122 | 3 | 0.334 |
ZAP70 |
0.637 | -0.021 | -1 | 0.658 |
FES |
0.625 | -0.129 | -1 | 0.652 |
MUSK |
0.623 | -0.178 | 1 | 0.492 |