Motif 631 (n=104)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKT7 RGPD3 S1312 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A6NKT7 RGPD3 S1587 ochoa RanBP2-like and GRIP domain-containing protein 3 None
F8WAN1 SPECC1L-ADORA2A S389 ochoa SPECC1L-ADORA2A readthrough (NMD candidate) None
M0R1B8 None S30 ochoa Uncharacterized protein None
O00571 DDX3X S28 ochoa ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.
O14715 RGPD8 S1586 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O43491 EPB41L2 S676 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O60361 NME2P1 S107 ochoa Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}.
O75376 NCOR1 S2352 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75995 SASH3 S117 ochoa SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}.
O95292 VAPB S156 ochoa Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}.
O95684 CEP43 S345 ochoa Centrosomal protein 43 (FGFR1 oncogene partner) Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
P07900 HSP90AA1 T540 ochoa Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 S532 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P0DJD0 RGPD1 S1296 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1304 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10809 HSPD1 S232 ochoa 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.
P12830 CDH1 S847 psp Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.
P13010 XRCC5 S692 ochoa X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.
P13804 ETFA S179 ochoa Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}.
P15531 NME1 S122 ochoa|psp Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.
P15884 TCF4 S505 ochoa Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.
P21796 VDAC1 S43 ochoa Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P22392 NME2 S122 ochoa Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.
P23588 EIF4B S504 ochoa|psp Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P25054 APC S2140 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P41227 NAA10 S213 ochoa N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.
P42166 TMPO S177 ochoa Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P43487 RANBP1 S21 ochoa Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}.
P46821 MAP1B S1415 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P49023 PXN S137 ochoa Paxillin Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
P49792 RANBP2 S2287 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2562 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51114 FXR1 S420 ochoa|psp RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P54725 RAD23A S140 ochoa UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}.
Q02156 PRKCE S344 ochoa Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}.
Q02952 AKAP12 S386 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q04656 ATP7A S1473 ochoa|psp Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}.
Q07157 TJP1 S828 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q09666 AHNAK S5746 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12888 TP53BP1 S310 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S530 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S1034 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13113 PDZK1IP1 S89 ochoa PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96) Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1 (PubMed:34880493, PubMed:37217492, PubMed:38057552). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (PubMed:37217492). {ECO:0000269|PubMed:34880493, ECO:0000269|PubMed:37217492, ECO:0000269|PubMed:38057552}.
Q13492 PICALM S315 ochoa Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.
Q13796 SHROOM2 S174 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14005 IL16 S1080 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14103 HNRNPD S80 ochoa Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}.
Q15398 DLGAP5 S774 ochoa Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.
Q4KMP7 TBC1D10B S274 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q58FF7 HSP90AB3P S405 ochoa Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q58FF8 HSP90AB2P S305 ochoa Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q58FG1 HSP90AA4P T248 ochoa Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q5T1M5 FKBP15 S1097 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5T200 ZC3H13 S1452 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5THJ4 VPS13D S2689 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5UIP0 RIF1 S1703 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VZL5 ZMYM4 S242 ochoa Zinc finger MYM-type protein 4 (Zinc finger protein 262) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q5W0B1 OBI1 S568 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q658Y4 FAM91A1 S691 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q68DQ2 CRYBG3 S2101 ochoa Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}.
Q69YQ0 SPECC1L S389 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q6ZMT1 STAC2 S228 ochoa SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}.
Q7Z3J3 RGPD4 S1312 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z3J3 RGPD4 S1587 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z401 DENND4A S912 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q86UE8 TLK2 S38 ochoa Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}.
Q86VM9 ZC3H18 S53 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q86WR7 PROSER2 S50 ochoa Proline and serine-rich protein 2 None
Q86X95 CIR1 S196 ochoa Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.
Q8IUF8 RIOX2 S44 ochoa Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.
Q8N163 CCAR2 S675 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N4X5 AFAP1L2 S303 ochoa Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.
Q8NC44 RETREG2 S344 ochoa Reticulophagy regulator 2 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
Q8TEV9 SMCR8 S421 ochoa Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.
Q8WU90 ZC3H15 S368 ochoa Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}.
Q96QC0 PPP1R10 S591 ochoa Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}.
Q96S94 CCNL2 S345 ochoa Cyclin-L2 (Paneth cell-enhanced expression protein) Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}.
Q96ST2 IWS1 S426 ochoa Protein IWS1 homolog (IWS1-like protein) Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}.
Q99081 TCF12 S553 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99666 RGPD5 S1586 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BSQ5 CCM2 S245 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BX66 SORBS1 S472 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXF6 RAB11FIP5 S361 ochoa Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.
Q9BYW2 SETD2 S1885 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9H0H5 RACGAP1 S164 ochoa|psp Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H0H5 RACGAP1 S274 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9HD67 MYO10 S962 ochoa Unconventional myosin-X (Unconventional myosin-10) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}.
Q9NSC5 HOMER3 S135 ochoa Homer protein homolog 3 (Homer-3) Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}.
Q9NSI6 BRWD1 S2011 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9NWQ8 PAG1 S295 ochoa Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Q9NX63 CHCHD3 Y53 ochoa MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q9P266 JCAD S1321 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9UHD1 CHORDC1 S125 ochoa Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}.
Q9UHW9 SLC12A6 S93 ochoa Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.
Q9UKI8 TLK1 S97 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9UKY7 CDV3 S197 ochoa Protein CDV3 homolog None
Q9UQ35 SRRM2 S864 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2M0 FAN1 S191 ochoa Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}.
Q9Y490 TLN1 S405 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y4F3 MARF1 S709 ochoa Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Q99816 TSG101 S229 Sugiyama Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.
O15143 ARPC1B S330 Sugiyama Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
Q9UQ80 PA2G4 S44 Sugiyama Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.
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reactome_id name p -log10_p
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.000026 4.581
R-HSA-9823730 Formation of definitive endoderm 0.000832 3.080
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.001585 2.800
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.001997 2.700
R-HSA-5336415 Uptake and function of diphtheria toxin 0.002454 2.610
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.002955 2.529
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.002730 2.564
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.004089 2.388
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 0.004089 2.388
R-HSA-9834752 Respiratory syncytial virus genome replication 0.003501 2.456
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.007178 2.144
R-HSA-5339700 Signaling by TCF7L2 mutants 0.021381 1.670
R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... 0.021381 1.670
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.028407 1.547
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.028407 1.547
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.028407 1.547
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.028407 1.547
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.028407 1.547
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.028407 1.547
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.028407 1.547
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.028407 1.547
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.028407 1.547
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.028407 1.547
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.028407 1.547
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.017688 1.752
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.007959 2.099
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.019203 1.717
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.013395 1.873
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.007659 2.116
R-HSA-9613829 Chaperone Mediated Autophagy 0.012216 1.913
R-HSA-4791275 Signaling by WNT in cancer 0.031103 1.507
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.028407 1.547
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.026755 1.573
R-HSA-1268020 Mitochondrial protein import 0.014462 1.840
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.008493 2.071
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.027932 1.554
R-HSA-3371556 Cellular response to heat stress 0.016854 1.773
R-HSA-9839394 TGFBR3 expression 0.021381 1.670
R-HSA-445355 Smooth Muscle Contraction 0.010025 1.999
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.013269 1.877
R-HSA-9629569 Protein hydroxylation 0.014299 1.845
R-HSA-1266695 Interleukin-7 signaling 0.021381 1.670
R-HSA-180292 GAB1 signalosome 0.012216 1.913
R-HSA-69275 G2/M Transition 0.016776 1.775
R-HSA-453274 Mitotic G2-G2/M phases 0.017415 1.759
R-HSA-525793 Myogenesis 0.022678 1.644
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.024006 1.620
R-HSA-8949215 Mitochondrial calcium ion transport 0.016524 1.782
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.028175 1.550
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 0.020507 1.688
R-HSA-9755088 Ribavirin ADME 0.016524 1.782
R-HSA-373755 Semaphorin interactions 0.015014 1.824
R-HSA-9730414 MITF-M-regulated melanocyte development 0.027224 1.565
R-HSA-9856651 MITF-M-dependent gene expression 0.007629 2.118
R-HSA-75153 Apoptotic execution phase 0.007211 2.142
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.032611 1.487
R-HSA-176417 Phosphorylation of Emi1 0.056013 1.252
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.056013 1.252
R-HSA-8951430 RUNX3 regulates WNT signaling 0.069524 1.158
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.069524 1.158
R-HSA-164843 2-LTR circle formation 0.089430 1.049
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.095972 1.018
R-HSA-4839744 Signaling by APC mutants 0.095972 1.018
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.095972 1.018
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.095972 1.018
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.095972 1.018
R-HSA-5339716 Signaling by GSK3beta mutants 0.102466 0.989
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.108915 0.963
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.108915 0.963
R-HSA-3000484 Scavenging by Class F Receptors 0.108915 0.963
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.108915 0.963
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.108915 0.963
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.108915 0.963
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.108915 0.963
R-HSA-196299 Beta-catenin phosphorylation cascade 0.127986 0.893
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.134253 0.872
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.134253 0.872
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.038919 1.410
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.146652 0.834
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.146652 0.834
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.146652 0.834
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.050955 1.293
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.170926 0.767
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.170926 0.767
R-HSA-429947 Deadenylation of mRNA 0.194515 0.711
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.082530 1.083
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.093366 1.030
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.093366 1.030
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.228656 0.641
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.097811 1.010
R-HSA-8854518 AURKA Activation by TPX2 0.100055 1.000
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.234205 0.630
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.234205 0.630
R-HSA-1855170 IPs transport between nucleus and cytosol 0.245185 0.611
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.245185 0.611
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.250616 0.601
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.250616 0.601
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.250616 0.601
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.116153 0.935
R-HSA-380287 Centrosome maturation 0.120867 0.918
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.261362 0.583
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.261362 0.583
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.155053 0.810
R-HSA-1643713 Signaling by EGFR in Cancer 0.206058 0.686
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.050764 1.294
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.050764 1.294
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.104587 0.981
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.160081 0.796
R-HSA-354192 Integrin signaling 0.245185 0.611
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.109174 0.962
R-HSA-191650 Regulation of gap junction activity 0.042309 1.374
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.217438 0.663
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.113814 0.944
R-HSA-4641265 Repression of WNT target genes 0.108915 0.963
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.070626 1.151
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.146652 0.834
R-HSA-418990 Adherens junctions interactions 0.093911 1.027
R-HSA-421270 Cell-cell junction organization 0.132777 0.877
R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.056013 1.252
R-HSA-446728 Cell junction organization 0.065063 1.187
R-HSA-6802957 Oncogenic MAPK signaling 0.145096 0.838
R-HSA-5205647 Mitophagy 0.256008 0.592
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.042309 1.374
R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.089430 1.049
R-HSA-192905 vRNP Assembly 0.095972 1.018
R-HSA-4839748 Signaling by AMER1 mutants 0.102466 0.989
R-HSA-4839735 Signaling by AXIN mutants 0.102466 0.989
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.108915 0.963
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.115317 0.938
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.042233 1.374
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.152786 0.816
R-HSA-350054 Notch-HLH transcription pathway 0.182805 0.738
R-HSA-8949613 Cristae formation 0.211769 0.674
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.223067 0.652
R-HSA-162588 Budding and maturation of HIV virion 0.234205 0.630
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.256008 0.592
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.214346 0.669
R-HSA-1500931 Cell-Cell communication 0.096320 1.016
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.228656 0.641
R-HSA-177243 Interactions of Rev with host cellular proteins 0.045648 1.341
R-HSA-3371511 HSF1 activation 0.038919 1.410
R-HSA-203615 eNOS activation 0.256008 0.592
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.228656 0.641
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.121674 0.915
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.164922 0.783
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.250616 0.601
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.176886 0.752
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.102466 0.989
R-HSA-9615710 Late endosomal microautophagy 0.223067 0.652
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.228656 0.641
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.142628 0.846
R-HSA-68877 Mitotic Prometaphase 0.197203 0.705
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.194515 0.711
R-HSA-2980766 Nuclear Envelope Breakdown 0.080413 1.095
R-HSA-6798695 Neutrophil degranulation 0.131941 0.880
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.211769 0.674
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.211769 0.674
R-HSA-180746 Nuclear import of Rev protein 0.256008 0.592
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.196014 0.708
R-HSA-1839124 FGFR1 mutant receptor activation 0.245185 0.611
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.152786 0.816
R-HSA-6794361 Neurexins and neuroligins 0.070095 1.154
R-HSA-201681 TCF dependent signaling in response to WNT 0.179121 0.747
R-HSA-426117 Cation-coupled Chloride cotransporters 0.069524 1.158
R-HSA-3371571 HSF1-dependent transactivation 0.068088 1.167
R-HSA-9663891 Selective autophagy 0.155053 0.810
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.223067 0.652
R-HSA-8853884 Transcriptional Regulation by VENTX 0.047393 1.324
R-HSA-9612973 Autophagy 0.037701 1.424
R-HSA-844456 The NLRP3 inflammasome 0.158876 0.799
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.040477 1.393
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.238136 0.623
R-HSA-162592 Integration of provirus 0.102466 0.989
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.040563 1.392
R-HSA-5693532 DNA Double-Strand Break Repair 0.126573 0.898
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.056013 1.252
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.056013 1.252
R-HSA-9005895 Pervasive developmental disorders 0.108915 0.963
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.108915 0.963
R-HSA-9697154 Disorders of Nervous System Development 0.108915 0.963
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.127986 0.893
R-HSA-3371568 Attenuation phase 0.045648 1.341
R-HSA-9675126 Diseases of mitotic cell cycle 0.239715 0.620
R-HSA-9930044 Nuclear RNA decay 0.245185 0.611
R-HSA-5617833 Cilium Assembly 0.191730 0.717
R-HSA-449836 Other interleukin signaling 0.158876 0.799
R-HSA-1227986 Signaling by ERBB2 0.086815 1.061
R-HSA-5689877 Josephin domain DUBs 0.089430 1.049
R-HSA-9675151 Disorders of Developmental Biology 0.140475 0.852
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.152786 0.816
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.228656 0.641
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.113814 0.944
R-HSA-6794362 Protein-protein interactions at synapses 0.145096 0.838
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.176886 0.752
R-HSA-162909 Host Interactions of HIV factors 0.262059 0.582
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.176886 0.752
R-HSA-622312 Inflammasomes 0.217438 0.663
R-HSA-8863795 Downregulation of ERBB2 signaling 0.228656 0.641
R-HSA-69278 Cell Cycle, Mitotic 0.131979 0.879
R-HSA-1852241 Organelle biogenesis and maintenance 0.099990 1.000
R-HSA-9609507 Protein localization 0.126573 0.898
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.134253 0.872
R-HSA-175474 Assembly Of The HIV Virion 0.176886 0.752
R-HSA-166208 mTORC1-mediated signalling 0.182805 0.738
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.228656 0.641
R-HSA-1640170 Cell Cycle 0.156225 0.806
R-HSA-3214842 HDMs demethylate histones 0.200307 0.698
R-HSA-936837 Ion transport by P-type ATPases 0.095581 1.020
R-HSA-68875 Mitotic Prophase 0.251417 0.600
R-HSA-162599 Late Phase of HIV Life Cycle 0.109504 0.961
R-HSA-8876725 Protein methylation 0.127986 0.893
R-HSA-9748787 Azathioprine ADME 0.066100 1.180
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.239715 0.620
R-HSA-114508 Effects of PIP2 hydrolysis 0.250616 0.601
R-HSA-73894 DNA Repair 0.140402 0.853
R-HSA-162587 HIV Life Cycle 0.038369 1.416
R-HSA-446353 Cell-extracellular matrix interactions 0.127986 0.893
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.091167 1.040
R-HSA-2262752 Cellular responses to stress 0.129207 0.889
R-HSA-5675482 Regulation of necroptotic cell death 0.245185 0.611
R-HSA-162906 HIV Infection 0.103903 0.983
R-HSA-9839373 Signaling by TGFBR3 0.058355 1.234
R-HSA-8953897 Cellular responses to stimuli 0.218964 0.660
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.111488 0.953
R-HSA-162594 Early Phase of HIV Life Cycle 0.170926 0.767
R-HSA-397014 Muscle contraction 0.234571 0.630
R-HSA-9705683 SARS-CoV-2-host interactions 0.105042 0.979
R-HSA-9022692 Regulation of MECP2 expression and activity 0.245185 0.611
R-HSA-3247509 Chromatin modifying enzymes 0.111998 0.951
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.200307 0.698
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.109504 0.961
R-HSA-9007101 Rab regulation of trafficking 0.243445 0.614
R-HSA-4839726 Chromatin organization 0.130254 0.885
R-HSA-1592230 Mitochondrial biogenesis 0.243445 0.614
R-HSA-9012852 Signaling by NOTCH3 0.076231 1.118
R-HSA-1834941 STING mediated induction of host immune responses 0.158876 0.799
R-HSA-211000 Gene Silencing by RNA 0.211716 0.674
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.054610 1.263
R-HSA-177929 Signaling by EGFR 0.078313 1.106
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.150057 0.824
R-HSA-5688426 Deubiquitination 0.137884 0.860
R-HSA-9758941 Gastrulation 0.120258 0.920
R-HSA-8878171 Transcriptional regulation by RUNX1 0.261442 0.583
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.175336 0.756
R-HSA-9006936 Signaling by TGFB family members 0.137903 0.860
R-HSA-2028269 Signaling by Hippo 0.146652 0.834
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.100603 0.997
R-HSA-5357801 Programmed Cell Death 0.080342 1.095
R-HSA-381038 XBP1(S) activates chaperone genes 0.150057 0.824
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.066921 1.174
R-HSA-109581 Apoptosis 0.141203 0.850
R-HSA-381070 IRE1alpha activates chaperones 0.165138 0.782
R-HSA-449147 Signaling by Interleukins 0.185355 0.732
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.043928 1.357
R-HSA-5339562 Uptake and actions of bacterial toxins 0.070095 1.154
R-HSA-194138 Signaling by VEGF 0.267382 0.573
R-HSA-162582 Signal Transduction 0.268770 0.571
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.271956 0.566
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.271956 0.566
R-HSA-5689896 Ovarian tumor domain proteases 0.271956 0.566
R-HSA-9694516 SARS-CoV-2 Infection 0.275816 0.559
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.277196 0.557
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.277196 0.557
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.277196 0.557
R-HSA-15869 Metabolism of nucleotides 0.280879 0.551
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.282399 0.549
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.282399 0.549
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.282399 0.549
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.282399 0.549
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.287564 0.541
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.287564 0.541
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.287564 0.541
R-HSA-1251985 Nuclear signaling by ERBB4 0.287564 0.541
R-HSA-9646399 Aggrephagy 0.287564 0.541
R-HSA-157118 Signaling by NOTCH 0.288694 0.540
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.292693 0.534
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.292693 0.534
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.292693 0.534
R-HSA-3214841 PKMTs methylate histone lysines 0.292693 0.534
R-HSA-5674135 MAP2K and MAPK activation 0.297785 0.526
R-HSA-9656223 Signaling by RAF1 mutants 0.297785 0.526
R-HSA-5655302 Signaling by FGFR1 in disease 0.297785 0.526
R-HSA-9018519 Estrogen-dependent gene expression 0.301936 0.520
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.302841 0.519
R-HSA-165159 MTOR signalling 0.302841 0.519
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.307037 0.513
R-HSA-8854214 TBC/RABGAPs 0.307861 0.512
R-HSA-9609646 HCMV Infection 0.308302 0.511
R-HSA-381119 Unfolded Protein Response (UPR) 0.309881 0.509
R-HSA-9664407 Parasite infection 0.312525 0.505
R-HSA-9664417 Leishmania phagocytosis 0.312525 0.505
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.312525 0.505
R-HSA-3928662 EPHB-mediated forward signaling 0.312845 0.505
R-HSA-373752 Netrin-1 signaling 0.312845 0.505
R-HSA-1632852 Macroautophagy 0.315168 0.501
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.317793 0.498
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.317793 0.498
R-HSA-6783310 Fanconi Anemia Pathway 0.317793 0.498
R-HSA-1489509 DAG and IP3 signaling 0.317793 0.498
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.322706 0.491
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.322706 0.491
R-HSA-9649948 Signaling downstream of RAS mutants 0.322706 0.491
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.322706 0.491
R-HSA-6802949 Signaling by RAS mutants 0.322706 0.491
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.322706 0.491
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.322706 0.491
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.322706 0.491
R-HSA-68886 M Phase 0.330772 0.480
R-HSA-9031628 NGF-stimulated transcription 0.332427 0.478
R-HSA-9766229 Degradation of CDH1 0.337235 0.472
R-HSA-157858 Gap junction trafficking and regulation 0.337235 0.472
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.337235 0.472
R-HSA-9679191 Potential therapeutics for SARS 0.341455 0.467
R-HSA-112382 Formation of RNA Pol II elongation complex 0.351456 0.454
R-HSA-199991 Membrane Trafficking 0.351649 0.454
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.354488 0.450
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.356128 0.448
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.356128 0.448
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.356128 0.448
R-HSA-168256 Immune System 0.358717 0.445
R-HSA-9610379 HCMV Late Events 0.359676 0.444
R-HSA-72649 Translation initiation complex formation 0.360767 0.443
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.360767 0.443
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.365279 0.437
R-HSA-418597 G alpha (z) signalling events 0.365373 0.437
R-HSA-3214815 HDACs deacetylate histones 0.365373 0.437
R-HSA-9824443 Parasitic Infection Pathways 0.369194 0.433
R-HSA-9658195 Leishmania infection 0.369194 0.433
R-HSA-72702 Ribosomal scanning and start codon recognition 0.369947 0.432
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.369947 0.432
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.369947 0.432
R-HSA-9764561 Regulation of CDH1 Function 0.374487 0.427
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.378995 0.421
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.378995 0.421
R-HSA-429914 Deadenylation-dependent mRNA decay 0.383471 0.416
R-HSA-194441 Metabolism of non-coding RNA 0.383471 0.416
R-HSA-191859 snRNP Assembly 0.383471 0.416
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.383471 0.416
R-HSA-5619102 SLC transporter disorders 0.385382 0.414
R-HSA-422475 Axon guidance 0.386504 0.413
R-HSA-983189 Kinesins 0.387915 0.411
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.387915 0.411
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.387915 0.411
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.387915 0.411
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.387915 0.411
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.387915 0.411
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.387915 0.411
R-HSA-5653656 Vesicle-mediated transport 0.389010 0.410
R-HSA-168325 Viral Messenger RNA Synthesis 0.392327 0.406
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.396707 0.402
R-HSA-9707616 Heme signaling 0.396707 0.402
R-HSA-6784531 tRNA processing in the nucleus 0.396707 0.402
R-HSA-8848021 Signaling by PTK6 0.401057 0.397
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.401057 0.397
R-HSA-195721 Signaling by WNT 0.402273 0.395
R-HSA-5689880 Ub-specific processing proteases 0.403113 0.395
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.405375 0.392
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.413919 0.383
R-HSA-168255 Influenza Infection 0.418121 0.379
R-HSA-5693606 DNA Double Strand Break Response 0.418145 0.379
R-HSA-8953854 Metabolism of RNA 0.421088 0.376
R-HSA-5218859 Regulated Necrosis 0.422341 0.374
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.430643 0.366
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.434750 0.362
R-HSA-453276 Regulation of mitotic cell cycle 0.434750 0.362
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.434750 0.362
R-HSA-8978934 Metabolism of cofactors 0.434750 0.362
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.438827 0.358
R-HSA-5578749 Transcriptional regulation by small RNAs 0.438827 0.358
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.438827 0.358
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.438827 0.358
R-HSA-9675108 Nervous system development 0.439266 0.357
R-HSA-983712 Ion channel transport 0.442708 0.354
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.442875 0.354
R-HSA-4086398 Ca2+ pathway 0.442875 0.354
R-HSA-69052 Switching of origins to a post-replicative state 0.442875 0.354
R-HSA-9824446 Viral Infection Pathways 0.446402 0.350
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.446894 0.350
R-HSA-69473 G2/M DNA damage checkpoint 0.446894 0.350
R-HSA-1236394 Signaling by ERBB4 0.446894 0.350
R-HSA-1226099 Signaling by FGFR in disease 0.446894 0.350
R-HSA-1266738 Developmental Biology 0.449401 0.347
R-HSA-1169408 ISG15 antiviral mechanism 0.450885 0.346
R-HSA-72163 mRNA Splicing - Major Pathway 0.454789 0.342
R-HSA-1980143 Signaling by NOTCH1 0.454847 0.342
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.458780 0.338
R-HSA-9609690 HCMV Early Events 0.459580 0.338
R-HSA-383280 Nuclear Receptor transcription pathway 0.462686 0.335
R-HSA-216083 Integrin cell surface interactions 0.462686 0.335
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.470413 0.328
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.470413 0.328
R-HSA-5693607 Processing of DNA double-strand break ends 0.474235 0.324
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.474235 0.324
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.478030 0.321
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.478030 0.321
R-HSA-72172 mRNA Splicing 0.480836 0.318
R-HSA-9707564 Cytoprotection by HMOX1 0.481798 0.317
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.485538 0.314
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.485538 0.314
R-HSA-141424 Amplification of signal from the kinetochores 0.492940 0.307
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.492940 0.307
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.492940 0.307
R-HSA-70268 Pyruvate metabolism 0.500235 0.301
R-HSA-68882 Mitotic Anaphase 0.508377 0.294
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.510629 0.292
R-HSA-168249 Innate Immune System 0.511289 0.291
R-HSA-9748784 Drug ADME 0.512875 0.290
R-HSA-8986944 Transcriptional Regulation by MECP2 0.514516 0.289
R-HSA-2682334 EPH-Ephrin signaling 0.521504 0.283
R-HSA-9006931 Signaling by Nuclear Receptors 0.522917 0.282
R-HSA-68867 Assembly of the pre-replicative complex 0.524960 0.280
R-HSA-9837999 Mitochondrial protein degradation 0.528392 0.277
R-HSA-1280215 Cytokine Signaling in Immune system 0.535734 0.271
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.538540 0.269
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.538540 0.269
R-HSA-8878159 Transcriptional regulation by RUNX3 0.541875 0.266
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.541875 0.266
R-HSA-69618 Mitotic Spindle Checkpoint 0.551735 0.258
R-HSA-70171 Glycolysis 0.551735 0.258
R-HSA-8939211 ESR-mediated signaling 0.554253 0.256
R-HSA-9009391 Extra-nuclear estrogen signaling 0.554975 0.256
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.564556 0.248
R-HSA-9860931 Response of endothelial cells to shear stress 0.564556 0.248
R-HSA-5619507 Activation of HOX genes during differentiation 0.567704 0.246
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.567704 0.246
R-HSA-9833110 RSV-host interactions 0.567704 0.246
R-HSA-9824439 Bacterial Infection Pathways 0.570766 0.244
R-HSA-5696398 Nucleotide Excision Repair 0.570830 0.243
R-HSA-5619115 Disorders of transmembrane transporters 0.575025 0.240
R-HSA-69239 Synthesis of DNA 0.577013 0.239
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.577013 0.239
R-HSA-9700206 Signaling by ALK in cancer 0.577013 0.239
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.580072 0.237
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.580072 0.237
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.583109 0.234
R-HSA-69002 DNA Replication Pre-Initiation 0.583109 0.234
R-HSA-5663205 Infectious disease 0.584255 0.233
R-HSA-202403 TCR signaling 0.586124 0.232
R-HSA-6803157 Antimicrobial peptides 0.589117 0.230
R-HSA-1483249 Inositol phosphate metabolism 0.592089 0.228
R-HSA-69620 Cell Cycle Checkpoints 0.597060 0.224
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.597969 0.223
R-HSA-9855142 Cellular responses to mechanical stimuli 0.597969 0.223
R-HSA-9679506 SARS-CoV Infections 0.599077 0.223
R-HSA-2029485 Role of phospholipids in phagocytosis 0.606632 0.217
R-HSA-9734767 Developmental Cell Lineages 0.606792 0.217
R-HSA-72613 Eukaryotic Translation Initiation 0.609478 0.215
R-HSA-72737 Cap-dependent Translation Initiation 0.609478 0.215
R-HSA-70326 Glucose metabolism 0.612304 0.213
R-HSA-2980736 Peptide hormone metabolism 0.612304 0.213
R-HSA-5693538 Homology Directed Repair 0.615110 0.211
R-HSA-9711123 Cellular response to chemical stress 0.616348 0.210
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.623407 0.205
R-HSA-76002 Platelet activation, signaling and aggregation 0.627581 0.202
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.628839 0.201
R-HSA-2132295 MHC class II antigen presentation 0.628839 0.201
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.636842 0.196
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.636842 0.196
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.636842 0.196
R-HSA-114608 Platelet degranulation 0.642082 0.192
R-HSA-69481 G2/M Checkpoints 0.642082 0.192
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.644674 0.191
R-HSA-9843745 Adipogenesis 0.654857 0.184
R-HSA-9909396 Circadian clock 0.657357 0.182
R-HSA-8856688 Golgi-to-ER retrograde transport 0.657357 0.182
R-HSA-1474228 Degradation of the extracellular matrix 0.657357 0.182
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.659839 0.181
R-HSA-3858494 Beta-catenin independent WNT signaling 0.669591 0.174
R-HSA-1643685 Disease 0.684546 0.165
R-HSA-8856828 Clathrin-mediated endocytosis 0.688271 0.162
R-HSA-69242 S Phase 0.699410 0.155
R-HSA-166520 Signaling by NTRKs 0.699410 0.155
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.703754 0.153
R-HSA-69306 DNA Replication 0.710155 0.149
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.712257 0.147
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.712257 0.147
R-HSA-1989781 PPARA activates gene expression 0.714345 0.146
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.718475 0.144
R-HSA-2467813 Separation of Sister Chromatids 0.732470 0.135
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.736209 0.133
R-HSA-72306 tRNA processing 0.745776 0.127
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.749455 0.125
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.754876 0.122
R-HSA-611105 Respiratory electron transport 0.760180 0.119
R-HSA-2559583 Cellular Senescence 0.763653 0.117
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.795752 0.099
R-HSA-389948 Co-inhibition by PD-1 0.795752 0.099
R-HSA-428157 Sphingolipid metabolism 0.797238 0.098
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.835972 0.078
R-HSA-382551 Transport of small molecules 0.854460 0.068
R-HSA-74160 Gene expression (Transcription) 0.862344 0.064
R-HSA-388841 Regulation of T cell activation by CD28 family 0.865399 0.063
R-HSA-597592 Post-translational protein modification 0.865603 0.063
R-HSA-112316 Neuronal System 0.870488 0.060
R-HSA-416476 G alpha (q) signalling events 0.873066 0.059
R-HSA-73857 RNA Polymerase II Transcription 0.880752 0.055
R-HSA-211945 Phase I - Functionalization of compounds 0.885456 0.053
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.888770 0.051
R-HSA-1280218 Adaptive Immune System 0.889228 0.051
R-HSA-212436 Generic Transcription Pathway 0.889353 0.051
R-HSA-5673001 RAF/MAP kinase cascade 0.894343 0.048
R-HSA-5684996 MAPK1/MAPK3 signaling 0.899639 0.046
R-HSA-212165 Epigenetic regulation of gene expression 0.917713 0.037
R-HSA-1474244 Extracellular matrix organization 0.922419 0.035
R-HSA-9006925 Intracellular signaling by second messengers 0.928458 0.032
R-HSA-5683057 MAPK family signaling cascades 0.931047 0.031
R-HSA-109582 Hemostasis 0.933286 0.030
R-HSA-196854 Metabolism of vitamins and cofactors 0.939172 0.027
R-HSA-392499 Metabolism of proteins 0.946442 0.024
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.947524 0.023
R-HSA-913531 Interferon Signaling 0.947524 0.023
R-HSA-425407 SLC-mediated transmembrane transport 0.952683 0.021
R-HSA-72766 Translation 0.962664 0.017
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.969212 0.014
R-HSA-211859 Biological oxidations 0.981435 0.008
R-HSA-388396 GPCR downstream signalling 0.997186 0.001
R-HSA-372790 Signaling by GPCR 0.998502 0.001
R-HSA-556833 Metabolism of lipids 0.999857 0.000
R-HSA-1430728 Metabolism 0.999991 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.788 0.128 2 0.870
CLK3CLK3 0.774 0.082 1 0.677
DSTYKDSTYK 0.772 0.070 2 0.868
KISKIS 0.770 0.058 1 0.546
IKKBIKKB 0.770 0.053 -2 0.712
CDC7CDC7 0.769 0.034 1 0.627
CAMK2GCAMK2G 0.768 0.084 2 0.796
IKKAIKKA 0.768 0.087 -2 0.712
GRK1GRK1 0.768 0.108 -2 0.763
MOSMOS 0.768 0.065 1 0.665
MTORMTOR 0.767 0.074 1 0.632
GRK6GRK6 0.766 0.105 1 0.619
IKKEIKKE 0.765 0.060 1 0.639
TBK1TBK1 0.764 0.030 1 0.631
RAF1RAF1 0.763 0.009 1 0.688
GRK4GRK4 0.762 0.073 -2 0.812
FAM20CFAM20C 0.762 0.046 2 0.565
ATRATR 0.762 0.036 1 0.658
GRK7GRK7 0.761 0.122 1 0.557
GRK5GRK5 0.760 0.023 -3 0.797
PRPKPRPK 0.760 -0.105 -1 0.792
GCN2GCN2 0.760 -0.085 2 0.774
PIM3PIM3 0.760 -0.004 -3 0.719
PDHK4PDHK4 0.759 -0.039 1 0.690
NEK7NEK7 0.758 -0.028 -3 0.746
BMPR2BMPR2 0.758 -0.049 -2 0.849
BMPR1BBMPR1B 0.757 0.084 1 0.566
CAMK1BCAMK1B 0.755 -0.029 -3 0.764
NDR2NDR2 0.755 -0.025 -3 0.719
NEK6NEK6 0.754 -0.037 -2 0.863
MLK1MLK1 0.754 -0.028 2 0.786
RIPK3RIPK3 0.753 -0.060 3 0.385
NLKNLK 0.753 -0.034 1 0.654
GSK3AGSK3A 0.752 0.162 4 0.502
ULK2ULK2 0.752 -0.110 2 0.748
ATMATM 0.752 0.001 1 0.606
CDK1CDK1 0.751 0.042 1 0.473
PLK1PLK1 0.751 0.044 -2 0.833
PDHK1PDHK1 0.751 -0.076 1 0.711
CAMK2BCAMK2B 0.751 0.063 2 0.776
MST4MST4 0.750 -0.008 2 0.847
CHAK2CHAK2 0.750 -0.033 -1 0.809
TLK2TLK2 0.750 0.075 1 0.657
PIM1PIM1 0.750 0.004 -3 0.672
PLK3PLK3 0.749 0.068 2 0.753
SRPK1SRPK1 0.749 -0.018 -3 0.631
WNK1WNK1 0.749 -0.029 -2 0.817
RSK2RSK2 0.749 0.011 -3 0.653
SKMLCKSKMLCK 0.748 -0.026 -2 0.791
HUNKHUNK 0.748 -0.111 2 0.824
DLKDLK 0.748 0.030 1 0.645
ERK5ERK5 0.748 -0.060 1 0.627
BMPR1ABMPR1A 0.747 0.077 1 0.558
CK2A2CK2A2 0.747 0.066 1 0.476
NIKNIK 0.746 -0.082 -3 0.784
ACVR2BACVR2B 0.746 0.052 -2 0.776
SMG1SMG1 0.746 0.051 1 0.636
PKN3PKN3 0.746 -0.064 -3 0.711
MARK4MARK4 0.746 -0.062 4 0.769
CDKL1CDKL1 0.745 -0.057 -3 0.686
CAMK2DCAMK2D 0.745 -0.000 -3 0.708
TGFBR2TGFBR2 0.745 -0.055 -2 0.779
NUAK2NUAK2 0.744 -0.060 -3 0.733
GSK3BGSK3B 0.744 0.134 4 0.496
CK1G1CK1G1 0.744 0.066 -3 0.561
CAMK2ACAMK2A 0.744 0.057 2 0.793
TGFBR1TGFBR1 0.744 0.011 -2 0.762
ANKRD3ANKRD3 0.744 -0.044 1 0.685
ULK1ULK1 0.744 -0.101 -3 0.752
PLK2PLK2 0.744 0.149 -3 0.836
TTBK2TTBK2 0.744 -0.048 2 0.687
YSK4YSK4 0.743 0.048 1 0.640
JNK3JNK3 0.743 0.020 1 0.506
DNAPKDNAPK 0.743 0.070 1 0.604
NDR1NDR1 0.743 -0.064 -3 0.717
ALK4ALK4 0.743 -0.004 -2 0.784
ALK2ALK2 0.743 0.035 -2 0.778
CAMLCKCAMLCK 0.743 -0.073 -2 0.780
WNK3WNK3 0.742 -0.122 1 0.676
CDK8CDK8 0.742 -0.024 1 0.542
NEK9NEK9 0.742 -0.094 2 0.811
ACVR2AACVR2A 0.742 0.022 -2 0.762
HIPK4HIPK4 0.742 -0.048 1 0.643
PKRPKR 0.742 -0.008 1 0.694
MASTLMASTL 0.742 -0.130 -2 0.792
JNK2JNK2 0.741 0.028 1 0.472
BCKDKBCKDK 0.741 -0.080 -1 0.693
PKN2PKN2 0.741 -0.049 -3 0.725
SRPK2SRPK2 0.740 -0.018 -3 0.559
PKCDPKCD 0.740 -0.040 2 0.761
SRPK3SRPK3 0.740 -0.027 -3 0.612
AMPKA1AMPKA1 0.739 -0.077 -3 0.737
PRKD1PRKD1 0.739 -0.058 -3 0.670
P90RSKP90RSK 0.739 -0.037 -3 0.656
MLK4MLK4 0.739 -0.020 2 0.694
PKACGPKACG 0.739 -0.026 -2 0.694
PRKD2PRKD2 0.739 -0.025 -3 0.636
LATS1LATS1 0.739 0.013 -3 0.738
MLK3MLK3 0.739 -0.044 2 0.715
CK1ECK1E 0.739 0.036 -3 0.551
LATS2LATS2 0.738 -0.044 -5 0.643
TSSK2TSSK2 0.738 -0.064 -5 0.715
NIM1NIM1 0.738 -0.082 3 0.404
DAPK2DAPK2 0.738 -0.098 -3 0.758
TSSK1TSSK1 0.737 -0.042 -3 0.755
MLK2MLK2 0.737 -0.111 2 0.785
RSK3RSK3 0.737 -0.033 -3 0.648
CK2A1CK2A1 0.737 0.056 1 0.450
MEK1MEK1 0.737 -0.047 2 0.816
GAKGAK 0.737 0.156 1 0.698
RIPK1RIPK1 0.737 -0.133 1 0.645
MEKK3MEKK3 0.737 0.015 1 0.629
PASKPASK 0.737 0.107 -3 0.728
CDK2CDK2 0.736 -0.013 1 0.529
CLK2CLK2 0.736 0.024 -3 0.646
GRK2GRK2 0.736 -0.009 -2 0.686
CK1DCK1D 0.736 0.054 -3 0.500
ICKICK 0.735 -0.062 -3 0.712
P70S6KBP70S6KB 0.735 -0.058 -3 0.686
CK1A2CK1A2 0.735 0.058 -3 0.499
CDKL5CDKL5 0.734 -0.071 -3 0.670
P38DP38D 0.734 0.025 1 0.464
IRE1IRE1 0.734 -0.126 1 0.661
VRK2VRK2 0.734 -0.122 1 0.705
CDK19CDK19 0.733 -0.037 1 0.512
P38BP38B 0.733 0.012 1 0.485
JNK1JNK1 0.733 0.028 1 0.456
TLK1TLK1 0.733 -0.014 -2 0.810
NUAK1NUAK1 0.733 -0.056 -3 0.681
MAPKAPK2MAPKAPK2 0.732 -0.045 -3 0.597
PLK4PLK4 0.732 -0.031 2 0.601
DYRK2DYRK2 0.732 -0.038 1 0.553
CDK3CDK3 0.732 -0.003 1 0.434
CLK4CLK4 0.732 -0.021 -3 0.666
AMPKA2AMPKA2 0.732 -0.084 -3 0.701
P38GP38G 0.731 -0.000 1 0.410
CDK5CDK5 0.731 -0.032 1 0.545
AURCAURC 0.731 -0.024 -2 0.584
RSK4RSK4 0.731 -0.005 -3 0.622
PRKXPRKX 0.731 0.021 -3 0.567
MSK1MSK1 0.730 -0.007 -3 0.617
MARK2MARK2 0.730 -0.048 4 0.706
GRK3GRK3 0.730 0.007 -2 0.649
PRP4PRP4 0.730 0.016 -3 0.710
P38AP38A 0.730 -0.018 1 0.551
CDK13CDK13 0.730 -0.046 1 0.509
QSKQSK 0.729 -0.069 4 0.741
IRE2IRE2 0.729 -0.120 2 0.699
MEKK2MEKK2 0.729 -0.022 2 0.769
ERK1ERK1 0.728 -0.019 1 0.487
MSK2MSK2 0.728 -0.063 -3 0.608
BRAFBRAF 0.728 -0.045 -4 0.702
CLK1CLK1 0.728 -0.021 -3 0.638
PINK1PINK1 0.728 -0.094 1 0.689
PKCBPKCB 0.727 -0.055 2 0.713
MARK3MARK3 0.727 -0.052 4 0.715
MAPKAPK3MAPKAPK3 0.727 -0.102 -3 0.635
CHAK1CHAK1 0.727 -0.113 2 0.705
PAK1PAK1 0.727 -0.067 -2 0.686
PKACBPKACB 0.727 -0.017 -2 0.612
CAMK4CAMK4 0.727 -0.110 -3 0.710
TAO3TAO3 0.726 0.012 1 0.635
CDK18CDK18 0.726 -0.021 1 0.475
AURAAURA 0.725 -0.017 -2 0.559
NEK5NEK5 0.725 -0.060 1 0.682
SIKSIK 0.725 -0.076 -3 0.644
NEK2NEK2 0.725 -0.103 2 0.769
PKCZPKCZ 0.725 -0.084 2 0.741
MEKK1MEKK1 0.725 -0.095 1 0.669
ERK2ERK2 0.724 -0.041 1 0.519
MYLK4MYLK4 0.724 -0.062 -2 0.691
MST3MST3 0.724 0.004 2 0.823
ZAKZAK 0.723 -0.054 1 0.641
PKCAPKCA 0.723 -0.059 2 0.699
PAK6PAK6 0.723 -0.014 -2 0.604
QIKQIK 0.723 -0.136 -3 0.712
PERKPERK 0.723 -0.126 -2 0.815
AURBAURB 0.723 -0.044 -2 0.585
CDK7CDK7 0.722 -0.069 1 0.530
CDK17CDK17 0.722 -0.023 1 0.416
PKCGPKCG 0.722 -0.079 2 0.708
CAMK1GCAMK1G 0.722 -0.065 -3 0.647
HIPK2HIPK2 0.721 -0.027 1 0.484
DRAK1DRAK1 0.721 -0.094 1 0.504
MST2MST2 0.721 0.045 1 0.654
MEK5MEK5 0.721 -0.150 2 0.789
MELKMELK 0.721 -0.120 -3 0.680
MNK2MNK2 0.721 -0.077 -2 0.730
CHK1CHK1 0.721 -0.086 -3 0.717
PAK3PAK3 0.720 -0.113 -2 0.687
CDK12CDK12 0.720 -0.051 1 0.483
PRKD3PRKD3 0.720 -0.074 -3 0.615
PKCHPKCH 0.720 -0.083 2 0.686
MARK1MARK1 0.720 -0.084 4 0.722
PAK2PAK2 0.719 -0.103 -2 0.673
CDK9CDK9 0.719 -0.069 1 0.519
DYRK4DYRK4 0.719 -0.020 1 0.489
DCAMKL1DCAMKL1 0.718 -0.062 -3 0.667
AKT2AKT2 0.718 -0.045 -3 0.576
TTBK1TTBK1 0.717 -0.071 2 0.603
TAK1TAK1 0.717 0.080 1 0.678
WNK4WNK4 0.717 -0.117 -2 0.816
HRIHRI 0.717 -0.168 -2 0.815
GCKGCK 0.717 0.076 1 0.647
MNK1MNK1 0.717 -0.080 -2 0.742
PKG2PKG2 0.717 -0.049 -2 0.615
SGK3SGK3 0.716 -0.058 -3 0.631
NEK11NEK11 0.715 -0.044 1 0.626
CAMKK1CAMKK1 0.715 -0.096 -2 0.724
HIPK1HIPK1 0.715 -0.054 1 0.576
NEK8NEK8 0.715 -0.107 2 0.774
MAPKAPK5MAPKAPK5 0.715 -0.117 -3 0.578
PIM2PIM2 0.715 -0.065 -3 0.630
IRAK4IRAK4 0.714 -0.138 1 0.682
PHKG1PHKG1 0.714 -0.128 -3 0.702
MINKMINK 0.713 0.017 1 0.679
CK1ACK1A 0.713 0.053 -3 0.427
EEF2KEEF2K 0.713 -0.047 3 0.466
SSTKSSTK 0.712 -0.080 4 0.733
CDK16CDK16 0.712 -0.022 1 0.438
MPSK1MPSK1 0.712 -0.061 1 0.680
BRSK1BRSK1 0.712 -0.132 -3 0.667
TNIKTNIK 0.711 -0.022 3 0.453
MST1MST1 0.710 0.021 1 0.656
PKACAPKACA 0.710 -0.028 -2 0.556
DYRK1ADYRK1A 0.710 -0.074 1 0.582
DCAMKL2DCAMKL2 0.710 -0.066 -3 0.699
SNRKSNRK 0.710 -0.201 2 0.621
HGKHGK 0.709 -0.032 3 0.462
IRAK1IRAK1 0.709 -0.169 -1 0.681
LKB1LKB1 0.709 -0.098 -3 0.723
BRSK2BRSK2 0.709 -0.148 -3 0.691
TAO2TAO2 0.709 -0.096 2 0.818
PDK1PDK1 0.709 -0.087 1 0.639
SMMLCKSMMLCK 0.709 -0.095 -3 0.702
CK1G3CK1G3 0.709 0.089 -3 0.383
CDK14CDK14 0.709 -0.050 1 0.509
HPK1HPK1 0.709 0.043 1 0.642
CAMKK2CAMKK2 0.709 -0.091 -2 0.712
STK33STK33 0.707 -0.058 2 0.588
NEK4NEK4 0.707 -0.091 1 0.674
P70S6KP70S6K 0.706 -0.078 -3 0.586
KHS2KHS2 0.706 0.040 1 0.673
CDK10CDK10 0.706 -0.035 1 0.494
DYRK3DYRK3 0.705 -0.067 1 0.580
SLKSLK 0.705 -0.017 -2 0.690
TTKTTK 0.705 0.030 -2 0.827
VRK1VRK1 0.705 -0.095 2 0.827
AKT1AKT1 0.705 -0.056 -3 0.584
PAK4PAK4 0.704 -0.038 -2 0.551
ALPHAK3ALPHAK3 0.704 0.039 -1 0.720
DAPK3DAPK3 0.704 -0.066 -3 0.686
DYRK1BDYRK1B 0.704 -0.070 1 0.506
PAK5PAK5 0.703 -0.053 -2 0.542
KHS1KHS1 0.703 0.020 1 0.674
CAMK1DCAMK1D 0.703 -0.074 -3 0.561
PKCTPKCT 0.703 -0.115 2 0.697
ERK7ERK7 0.702 -0.049 2 0.503
LRRK2LRRK2 0.701 -0.116 2 0.805
DAPK1DAPK1 0.701 -0.055 -3 0.669
LOKLOK 0.701 -0.062 -2 0.741
PKCIPKCI 0.700 -0.105 2 0.708
HIPK3HIPK3 0.700 -0.101 1 0.562
YANK3YANK3 0.700 0.013 2 0.400
PHKG2PHKG2 0.700 -0.124 -3 0.695
CDK6CDK6 0.699 -0.059 1 0.502
MRCKAMRCKA 0.699 -0.030 -3 0.639
PKCEPKCE 0.699 -0.070 2 0.691
NEK1NEK1 0.698 -0.128 1 0.663
CK1G2CK1G2 0.698 0.081 -3 0.477
OSR1OSR1 0.698 -0.024 2 0.773
MAP3K15MAP3K15 0.698 -0.107 1 0.629
MEKK6MEKK6 0.697 -0.127 1 0.653
MRCKBMRCKB 0.696 -0.043 -3 0.623
ROCK2ROCK2 0.695 -0.044 -3 0.666
PBKPBK 0.695 -0.025 1 0.661
PDHK3_TYRPDHK3_TYR 0.694 0.062 4 0.787
CDK4CDK4 0.694 -0.068 1 0.480
PDHK4_TYRPDHK4_TYR 0.694 0.101 2 0.846
SGK1SGK1 0.694 -0.043 -3 0.491
BMPR2_TYRBMPR2_TYR 0.693 0.102 -1 0.808
MEK2MEK2 0.693 -0.170 2 0.778
YSK1YSK1 0.692 -0.096 2 0.779
MAP2K6_TYRMAP2K6_TYR 0.692 0.067 -1 0.811
RIPK2RIPK2 0.692 -0.189 1 0.596
AKT3AKT3 0.690 -0.052 -3 0.500
PDHK1_TYRPDHK1_TYR 0.689 0.062 -1 0.826
CHK2CHK2 0.689 -0.077 -3 0.520
DMPK1DMPK1 0.688 -0.030 -3 0.652
CAMK1ACAMK1A 0.688 -0.079 -3 0.533
MAKMAK 0.688 -0.041 -2 0.633
MAP2K4_TYRMAP2K4_TYR 0.687 -0.015 -1 0.803
HASPINHASPIN 0.686 -0.055 -1 0.636
PKN1PKN1 0.685 -0.112 -3 0.599
BIKEBIKE 0.685 -0.002 1 0.632
BUB1BUB1 0.685 -0.069 -5 0.687
MYO3AMYO3A 0.684 -0.049 1 0.661
SBKSBK 0.683 -0.061 -3 0.456
MAP2K7_TYRMAP2K7_TYR 0.682 -0.138 2 0.823
PKG1PKG1 0.682 -0.064 -2 0.530
NEK3NEK3 0.681 -0.172 1 0.647
MYO3BMYO3B 0.681 -0.085 2 0.777
ROCK1ROCK1 0.680 -0.062 -3 0.637
CRIKCRIK 0.679 -0.043 -3 0.573
MOKMOK 0.679 -0.090 1 0.584
TESK1_TYRTESK1_TYR 0.679 -0.175 3 0.484
YANK2YANK2 0.677 0.017 2 0.408
PKMYT1_TYRPKMYT1_TYR 0.677 -0.155 3 0.453
PINK1_TYRPINK1_TYR 0.676 -0.195 1 0.650
STLK3STLK3 0.676 -0.080 1 0.607
YES1YES1 0.675 -0.035 -1 0.787
ASK1ASK1 0.675 -0.146 1 0.620
EPHA6EPHA6 0.674 -0.055 -1 0.794
FGRFGR 0.674 -0.039 1 0.652
FYNFYN 0.673 0.042 -1 0.761
TXKTXK 0.673 -0.005 1 0.589
BLKBLK 0.672 -0.008 -1 0.796
TAO1TAO1 0.672 -0.134 1 0.605
FERFER 0.671 -0.073 1 0.658
EPHA4EPHA4 0.671 -0.024 2 0.764
RETRET 0.671 -0.149 1 0.655
EPHB4EPHB4 0.671 -0.086 -1 0.763
LCKLCK 0.669 -0.032 -1 0.787
HCKHCK 0.669 -0.073 -1 0.782
INSRRINSRR 0.668 -0.110 3 0.375
SRMSSRMS 0.668 -0.062 1 0.624
CSF1RCSF1R 0.668 -0.124 3 0.360
DDR1DDR1 0.668 -0.128 4 0.730
MST1RMST1R 0.668 -0.183 3 0.383
AAK1AAK1 0.667 0.014 1 0.565
LIMK2_TYRLIMK2_TYR 0.667 -0.184 -3 0.778
EPHB2EPHB2 0.666 -0.048 -1 0.749
TYK2TYK2 0.666 -0.214 1 0.667
ABL2ABL2 0.666 -0.109 -1 0.765
KITKIT 0.666 -0.100 3 0.383
TYRO3TYRO3 0.666 -0.184 3 0.379
ITKITK 0.665 -0.058 -1 0.749
JAK2JAK2 0.665 -0.182 1 0.666
EPHB1EPHB1 0.665 -0.086 1 0.625
FLT1FLT1 0.665 -0.024 -1 0.761
FGFR2FGFR2 0.664 -0.106 3 0.441
ABL1ABL1 0.664 -0.096 -1 0.756
ROS1ROS1 0.663 -0.194 3 0.352
JAK3JAK3 0.663 -0.139 1 0.624
FLT3FLT3 0.663 -0.132 3 0.376
LIMK1_TYRLIMK1_TYR 0.662 -0.259 2 0.808
TNK2TNK2 0.662 -0.131 3 0.361
METMET 0.662 -0.091 3 0.368
KDRKDR 0.662 -0.122 3 0.360
SRCSRC 0.661 -0.019 -1 0.752
LYNLYN 0.661 -0.052 3 0.338
SYKSYK 0.661 0.044 -1 0.720
EPHB3EPHB3 0.660 -0.115 -1 0.746
BMXBMX 0.660 -0.061 -1 0.694
PTK2PTK2 0.660 0.018 -1 0.731
FGFR3FGFR3 0.660 -0.082 3 0.421
ERBB2ERBB2 0.660 -0.090 1 0.599
NEK10_TYRNEK10_TYR 0.659 -0.102 1 0.581
TECTEC 0.657 -0.082 -1 0.694
TEKTEK 0.657 -0.163 3 0.361
EPHA3EPHA3 0.656 -0.091 2 0.732
EGFREGFR 0.656 -0.030 1 0.506
PTK6PTK6 0.656 -0.106 -1 0.659
EPHA7EPHA7 0.656 -0.079 2 0.756
FGFR1FGFR1 0.656 -0.172 3 0.378
BTKBTK 0.655 -0.125 -1 0.716
PDGFRBPDGFRB 0.655 -0.179 3 0.382
MERTKMERTK 0.655 -0.123 3 0.374
FGFR4FGFR4 0.655 -0.031 -1 0.702
FRKFRK 0.655 -0.090 -1 0.804
EPHA5EPHA5 0.654 -0.067 2 0.743
NTRK1NTRK1 0.652 -0.162 -1 0.730
FLT4FLT4 0.652 -0.136 3 0.385
AXLAXL 0.652 -0.169 3 0.378
CSKCSK 0.650 -0.084 2 0.758
EPHA8EPHA8 0.650 -0.078 -1 0.739
TNK1TNK1 0.650 -0.185 3 0.364
JAK1JAK1 0.650 -0.138 1 0.624
TNNI3K_TYRTNNI3K_TYR 0.649 -0.126 1 0.695
WEE1_TYRWEE1_TYR 0.649 -0.129 -1 0.675
LTKLTK 0.649 -0.160 3 0.347
MATKMATK 0.649 -0.105 -1 0.694
ERBB4ERBB4 0.648 -0.037 1 0.503
NTRK2NTRK2 0.648 -0.173 3 0.366
DDR2DDR2 0.648 -0.096 3 0.381
INSRINSR 0.647 -0.164 3 0.350
ALKALK 0.647 -0.186 3 0.326
PDGFRAPDGFRA 0.646 -0.239 3 0.370
PTK2BPTK2B 0.646 -0.104 -1 0.722
EPHA2EPHA2 0.645 -0.064 -1 0.709
NTRK3NTRK3 0.645 -0.143 -1 0.684
EPHA1EPHA1 0.641 -0.177 3 0.349
IGF1RIGF1R 0.641 -0.122 3 0.334
ZAP70ZAP70 0.637 -0.021 -1 0.658
FESFES 0.625 -0.129 -1 0.652
MUSKMUSK 0.623 -0.178 1 0.492