Motif 630 (n=111)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S230 | ochoa | Golgin A8 family member Q | None |
| A0MZ66 | SHTN1 | S561 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NHL2 | TUBAL3 | Y406 | ochoa | Tubulin alpha chain-like 3 (EC 3.6.5.-) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S138 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| I6L899 | GOLGA8R | S230 | ochoa | Golgin subfamily A member 8R | None |
| O00193 | SMAP | S90 | ochoa | Small acidic protein | None |
| O15355 | PPM1G | S173 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43164 | PJA2 | S452 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O60303 | KATNIP | S233 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60315 | ZEB2 | Y1121 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O75150 | RNF40 | S600 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75554 | WBP4 | S227 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O76070 | SNCG | Y39 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O94880 | PHF14 | S232 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94992 | HEXIM1 | S98 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95671 | ASMTL | S255 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| O95747 | OXSR1 | S324 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| P07197 | NEFM | S558 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07550 | ADRB2 | S355 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07900 | HSP90AA1 | S505 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08069 | IGF1R | S975 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08069 | IGF1R | S1009 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08238 | HSP90AB1 | S497 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P0DPH7 | TUBA3C | Y399 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y399 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12883 | MYH7 | S1518 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P18583 | SON | S1595 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P23588 | EIF4B | S589 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P32004 | L1CAM | Y1229 | psp | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P37840 | SNCA | Y39 | ochoa|psp | Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}. |
| P38432 | COIL | S105 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P46734 | MAP2K3 | S253 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P52272 | HNRNPM | S29 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P53350 | PLK1 | S383 | ochoa|psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P68363 | TUBA1B | Y399 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y399 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00653 | NFKB2 | S858 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01538 | MYT1 | S91 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q02952 | AKAP12 | S1295 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1727 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q08J23 | NSUN2 | S724 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q09019 | DMWD | T388 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
| Q12789 | GTF3C1 | S1962 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12802 | AKAP13 | S2479 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12983 | BNIP3 | S144 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13033 | STRN3 | S323 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q14204 | DYNC1H1 | S3917 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q15047 | SETDB1 | S880 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15390 | MTFR1 | Y286 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q16143 | SNCB | Y39 | ochoa | Beta-synuclein | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Q16825 | PTPN21 | S673 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q1KMD3 | HNRNPUL2 | S138 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q27J81 | INF2 | S1158 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q29RF7 | PDS5A | S1182 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q58FF7 | HSP90AB3P | S370 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JTH9 | RRP12 | S460 | ochoa | RRP12-like protein | None |
| Q6NYC8 | PPP1R18 | S401 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P995 | FAM171B | S504 | ochoa | Protein FAM171B | None |
| Q6PL18 | ATAD2 | S1233 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZN30 | BNC2 | S937 | ochoa | Zinc finger protein basonuclin-2 | Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}. |
| Q71U36 | TUBA1A | Y399 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L590 | MCM10 | S54 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z591 | AKNA | S1206 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S805 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6I6 | ARHGAP30 | S359 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z7L1 | SLFN11 | S750 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86YS3 | RAB11FIP4 | S527 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q8IW35 | CEP97 | S813 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IX01 | SUGP2 | S1032 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8N302 | AGGF1 | S176 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N302 | AGGF1 | S620 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3D4 | EHBP1L1 | S784 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N573 | OXR1 | S388 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8NEF9 | SRFBP1 | S239 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8TDP1 | RNASEH2C | S92 | ochoa | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| Q8WVT3 | TRAPPC12 | S75 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q92766 | RREB1 | S1320 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q969R2 | OSBP2 | S430 | ochoa | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) | Binds 7-ketocholesterol (PubMed:11278871). Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (By similarity). {ECO:0000250|UniProtKB:Q8CF21, ECO:0000269|PubMed:11278871}. |
| Q96HH9 | GRAMD2B | S296 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96MG2 | JSRP1 | S51 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96T23 | RSF1 | S1406 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99684 | GFI1 | S69 | ochoa | Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) | Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}. |
| Q9BQE3 | TUBA1C | Y399 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRT3 | MIEN1 | Y50 | psp | Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35) | Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}. |
| Q9BSV6 | TSEN34 | S131 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BSV6 | TSEN34 | S142 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BTK6 | PAGR1 | S42 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BUB4 | ADAT1 | S191 | ochoa | tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) | Specifically deaminates adenosine-37 to inosine in tRNA-Ala. |
| Q9BVJ6 | UTP14A | S480 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9GZR1 | SENP6 | S42 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H2D6 | TRIOBP | S2053 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9NSI6 | BRWD1 | S2118 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NY65 | TUBA8 | Y399 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9UJU6 | DBNL | S106 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9ULL8 | SHROOM4 | S155 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UPV7 | PHF24 | S73 | ochoa | PHD finger protein 24 | None |
| O15075 | DCLK1 | S160 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O75582 | RPS6KA5 | S633 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Q6PEY2 | TUBA3E | Y399 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P09110 | ACAA1 | S206 | Sugiyama | 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase) (EC 2.3.1.9) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase) | Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). {ECO:0000305|PubMed:11734571, ECO:0000305|PubMed:2882519}. |
| O95831 | AIFM1 | S519 | Sugiyama | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| Q92823 | NRCAM | Y1276 | SIGNOR | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Q9Y4K0 | LOXL2 | S411 | Sugiyama | Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:24414204, PubMed:27735137). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P58022, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20026874, ECO:0000269|PubMed:20306300, ECO:0000269|PubMed:21835952, ECO:0000269|PubMed:24239292, ECO:0000269|PubMed:24414204, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:27735137}. |
| P10636 | MAPT | S641 | SIGNOR|EPSD | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Q9Y6W5 | WASF2 | S442 | Sugiyama | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| P20933 | AGA | S49 | Sugiyama | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. {ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874, ECO:0000269|PubMed:2401370}. |
| Q10570 | CPSF1 | S712 | Sugiyama | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
| O60879 | DIAPH2 | S196 | SIGNOR | Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}. |
| Q8WXE0 | CASKIN2 | S1154 | Sugiyama | Caskin-2 (CASK-interacting protein 2) | None |
| P04920 | SLC4A2 | S56 | Sugiyama | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P36578 | RPL4 | S139 | Sugiyama | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-437239 | Recycling pathway of L1 | 1.887379e-14 | 13.724 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.654232e-13 | 12.781 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.513234e-13 | 12.820 |
| R-HSA-9646399 | Aggrephagy | 1.135758e-13 | 12.945 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.242651e-13 | 12.649 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.110845e-13 | 12.507 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.691803e-13 | 12.329 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.041345e-13 | 12.095 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.346900e-12 | 11.630 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.319123e-11 | 10.880 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.483780e-11 | 10.829 |
| R-HSA-373760 | L1CAM interactions | 2.426559e-11 | 10.615 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.353684e-11 | 10.628 |
| R-HSA-190861 | Gap junction assembly | 3.646150e-11 | 10.438 |
| R-HSA-69275 | G2/M Transition | 5.029410e-11 | 10.298 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.746703e-11 | 10.241 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.593559e-11 | 10.181 |
| R-HSA-9833482 | PKR-mediated signaling | 8.725276e-11 | 10.059 |
| R-HSA-983189 | Kinesins | 1.371878e-10 | 9.863 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.725829e-10 | 9.763 |
| R-HSA-9663891 | Selective autophagy | 2.408129e-10 | 9.618 |
| R-HSA-190828 | Gap junction trafficking | 2.891902e-10 | 9.539 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.702605e-10 | 9.328 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.503495e-10 | 9.259 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.405630e-10 | 9.193 |
| R-HSA-5617833 | Cilium Assembly | 7.107015e-10 | 9.148 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.277927e-10 | 9.138 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.360887e-09 | 8.627 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.625815e-09 | 8.441 |
| R-HSA-68877 | Mitotic Prometaphase | 8.423018e-09 | 8.075 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.378868e-09 | 8.077 |
| R-HSA-9612973 | Autophagy | 9.079741e-09 | 8.042 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.001976e-08 | 7.999 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.001976e-08 | 7.999 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.054612e-08 | 7.977 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.481707e-08 | 7.829 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.665784e-08 | 7.778 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.829998e-08 | 7.738 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.633682e-08 | 7.579 |
| R-HSA-1632852 | Macroautophagy | 3.530281e-08 | 7.452 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.484351e-08 | 7.261 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.233884e-08 | 7.084 |
| R-HSA-391251 | Protein folding | 9.118760e-08 | 7.040 |
| R-HSA-68882 | Mitotic Anaphase | 2.394120e-07 | 6.621 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.503127e-07 | 6.602 |
| R-HSA-5620924 | Intraflagellar transport | 2.595672e-07 | 6.586 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.871915e-07 | 6.542 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.313852e-07 | 6.275 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.765818e-07 | 6.057 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.866141e-06 | 5.729 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.240665e-06 | 5.650 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.038819e-06 | 5.517 |
| R-HSA-422475 | Axon guidance | 5.221124e-06 | 5.282 |
| R-HSA-9609690 | HCMV Early Events | 5.496911e-06 | 5.260 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.973966e-06 | 5.157 |
| R-HSA-1640170 | Cell Cycle | 8.193746e-06 | 5.087 |
| R-HSA-68886 | M Phase | 1.088619e-05 | 4.963 |
| R-HSA-9675108 | Nervous system development | 1.143533e-05 | 4.942 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.058721e-05 | 4.975 |
| R-HSA-9609646 | HCMV Infection | 3.811702e-05 | 4.419 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.084174e-04 | 3.965 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.003884e-04 | 3.698 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.085082e-04 | 3.681 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.085082e-04 | 3.681 |
| R-HSA-913531 | Interferon Signaling | 2.336922e-04 | 3.631 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.519457e-04 | 3.599 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.653481e-04 | 3.576 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.798907e-04 | 3.420 |
| R-HSA-380287 | Centrosome maturation | 4.241396e-04 | 3.372 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.730640e-04 | 3.172 |
| R-HSA-156711 | Polo-like kinase mediated events | 7.222527e-04 | 3.141 |
| R-HSA-5660489 | MTF1 activates gene expression | 9.626734e-04 | 3.017 |
| R-HSA-112316 | Neuronal System | 1.126084e-03 | 2.948 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.140964e-03 | 2.943 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.283714e-03 | 2.892 |
| R-HSA-199991 | Membrane Trafficking | 1.510757e-03 | 2.821 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.845199e-03 | 2.734 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 2.622578e-03 | 2.581 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 3.740023e-03 | 2.427 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 3.740023e-03 | 2.427 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.595232e-03 | 2.444 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 4.368093e-03 | 2.360 |
| R-HSA-9832991 | Formation of the posterior neural plate | 5.041456e-03 | 2.297 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 5.759414e-03 | 2.240 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.965301e-03 | 2.224 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 9.063559e-03 | 2.043 |
| R-HSA-9823739 | Formation of the anterior neural plate | 9.063559e-03 | 2.043 |
| R-HSA-1266738 | Developmental Biology | 1.007443e-02 | 1.997 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.050939e-02 | 1.978 |
| R-HSA-2262752 | Cellular responses to stress | 1.058940e-02 | 1.975 |
| R-HSA-5660526 | Response to metal ions | 1.096568e-02 | 1.960 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.302755e-02 | 1.885 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.411680e-02 | 1.850 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 1.411680e-02 | 1.850 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.761041e-02 | 1.754 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.277300e-02 | 1.643 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.555993e-02 | 1.592 |
| R-HSA-622312 | Inflammasomes | 2.700281e-02 | 1.569 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 2.937182e-02 | 1.532 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 2.937182e-02 | 1.532 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 2.937182e-02 | 1.532 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 2.937182e-02 | 1.532 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 2.937182e-02 | 1.532 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 2.937182e-02 | 1.532 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 2.937182e-02 | 1.532 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 2.937182e-02 | 1.532 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 2.937182e-02 | 1.532 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 2.937182e-02 | 1.532 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 2.937182e-02 | 1.532 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 2.937182e-02 | 1.532 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.309087e-02 | 1.480 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.468932e-02 | 1.460 |
| R-HSA-3371511 | HSF1 activation | 4.137313e-02 | 1.383 |
| R-HSA-3371568 | Attenuation phase | 4.849670e-02 | 1.314 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.437588e-02 | 1.353 |
| R-HSA-1566948 | Elastic fibre formation | 4.488192e-02 | 1.348 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.667631e-02 | 1.331 |
| R-HSA-109582 | Hemostasis | 3.840664e-02 | 1.416 |
| R-HSA-9824446 | Viral Infection Pathways | 4.704926e-02 | 1.327 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.861146e-02 | 1.313 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.861146e-02 | 1.313 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.861146e-02 | 1.313 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.034263e-02 | 1.298 |
| R-HSA-447038 | NrCAM interactions | 5.083776e-02 | 1.294 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 5.083776e-02 | 1.294 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 5.788792e-02 | 1.237 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 7.183283e-02 | 1.144 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 5.788792e-02 | 1.237 |
| R-HSA-176417 | Phosphorylation of Emi1 | 5.788792e-02 | 1.237 |
| R-HSA-199920 | CREB phosphorylation | 6.488615e-02 | 1.188 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 6.488615e-02 | 1.188 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 6.488615e-02 | 1.188 |
| R-HSA-3371571 | HSF1-dependent transactivation | 7.220174e-02 | 1.141 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.192830e-02 | 1.208 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.192830e-02 | 1.208 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.123446e-02 | 1.213 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 5.788792e-02 | 1.237 |
| R-HSA-447043 | Neurofascin interactions | 6.488615e-02 | 1.188 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.245113e-02 | 1.204 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.367904e-02 | 1.196 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.790995e-02 | 1.108 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.367904e-02 | 1.196 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.790995e-02 | 1.108 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.765264e-02 | 1.239 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.742967e-02 | 1.171 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.127923e-02 | 1.147 |
| R-HSA-72306 | tRNA processing | 5.360967e-02 | 1.271 |
| R-HSA-75153 | Apoptotic execution phase | 6.192830e-02 | 1.208 |
| R-HSA-1280218 | Adaptive Immune System | 5.504358e-02 | 1.259 |
| R-HSA-390696 | Adrenoceptors | 7.872833e-02 | 1.104 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.201411e-02 | 1.086 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.201411e-02 | 1.086 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 8.298081e-02 | 1.081 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 8.557303e-02 | 1.068 |
| R-HSA-448706 | Interleukin-1 processing | 8.557303e-02 | 1.068 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 8.967002e-02 | 1.047 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 9.236729e-02 | 1.034 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 9.236729e-02 | 1.034 |
| R-HSA-450294 | MAP kinase activation | 9.421548e-02 | 1.026 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.124511e-01 | 0.949 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.124511e-01 | 0.949 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.449495e-01 | 0.839 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.513061e-01 | 0.820 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.513061e-01 | 0.820 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.762674e-01 | 0.754 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.762674e-01 | 0.754 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.823931e-01 | 0.739 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.556688e-01 | 0.808 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.556688e-01 | 0.808 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.884736e-01 | 0.725 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.884736e-01 | 0.725 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.124511e-01 | 0.949 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.823931e-01 | 0.739 |
| R-HSA-445144 | Signal transduction by L1 | 1.700962e-01 | 0.769 |
| R-HSA-192905 | vRNP Assembly | 9.911149e-02 | 1.004 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.124511e-01 | 0.949 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.190473e-01 | 0.924 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.320942e-01 | 0.879 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.385456e-01 | 0.858 |
| R-HSA-6798695 | Neutrophil degranulation | 1.477331e-01 | 0.831 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.147832e-01 | 0.940 |
| R-HSA-198753 | ERK/MAPK targets | 1.762674e-01 | 0.754 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.576159e-01 | 0.802 |
| R-HSA-425381 | Bicarbonate transporters | 9.911149e-02 | 1.004 |
| R-HSA-448424 | Interleukin-17 signaling | 1.154374e-01 | 0.938 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.749799e-01 | 0.757 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.576159e-01 | 0.802 |
| R-HSA-9659379 | Sensory processing of sound | 1.377322e-01 | 0.861 |
| R-HSA-6784531 | tRNA processing in the nucleus | 9.651289e-02 | 1.015 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.106203e-01 | 0.956 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.884736e-01 | 0.725 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.545135e-01 | 0.811 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.011553e-01 | 0.995 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 1.058586e-01 | 0.975 |
| R-HSA-210991 | Basigin interactions | 1.762674e-01 | 0.754 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.277593e-01 | 0.894 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 9.651289e-02 | 1.015 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.225643e-01 | 0.912 |
| R-HSA-4839726 | Chromatin organization | 1.421796e-01 | 0.847 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.449495e-01 | 0.839 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.513061e-01 | 0.820 |
| R-HSA-373755 | Semaphorin interactions | 9.882627e-02 | 1.005 |
| R-HSA-1474290 | Collagen formation | 1.819924e-01 | 0.740 |
| R-HSA-162582 | Signal Transduction | 1.877275e-01 | 0.726 |
| R-HSA-168256 | Immune System | 1.304148e-01 | 0.885 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.084953e-01 | 0.965 |
| R-HSA-5663205 | Infectious disease | 1.350751e-01 | 0.869 |
| R-HSA-8953854 | Metabolism of RNA | 1.890574e-01 | 0.723 |
| R-HSA-429947 | Deadenylation of mRNA | 2.005005e-01 | 0.698 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.005005e-01 | 0.698 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.005005e-01 | 0.698 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.005005e-01 | 0.698 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.005005e-01 | 0.698 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.007894e-01 | 0.697 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.034940e-01 | 0.691 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.064474e-01 | 0.685 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.068802e-01 | 0.684 |
| R-HSA-449147 | Signaling by Interleukins | 2.076993e-01 | 0.683 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.123505e-01 | 0.673 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.252651e-01 | 0.647 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.252651e-01 | 0.647 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.297998e-01 | 0.639 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.297998e-01 | 0.639 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.297998e-01 | 0.639 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.355306e-01 | 0.628 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.355306e-01 | 0.628 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.355306e-01 | 0.628 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.355306e-01 | 0.628 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.355306e-01 | 0.628 |
| R-HSA-5357801 | Programmed Cell Death | 2.360356e-01 | 0.627 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.412191e-01 | 0.618 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.499527e-01 | 0.602 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.524706e-01 | 0.598 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.524706e-01 | 0.598 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.524706e-01 | 0.598 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.527031e-01 | 0.597 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.527031e-01 | 0.597 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.635565e-01 | 0.579 |
| R-HSA-203615 | eNOS activation | 2.635565e-01 | 0.579 |
| R-HSA-3371556 | Cellular response to heat stress | 2.664643e-01 | 0.574 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.690382e-01 | 0.570 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.744794e-01 | 0.561 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.744794e-01 | 0.561 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 2.798804e-01 | 0.553 |
| R-HSA-194138 | Signaling by VEGF | 2.802269e-01 | 0.552 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 2.852416e-01 | 0.545 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.852416e-01 | 0.545 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 2.852416e-01 | 0.545 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.852416e-01 | 0.545 |
| R-HSA-69481 | G2/M Checkpoints | 2.857281e-01 | 0.544 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.905632e-01 | 0.537 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.905632e-01 | 0.537 |
| R-HSA-5260271 | Diseases of Immune System | 2.958455e-01 | 0.529 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.958455e-01 | 0.529 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.958455e-01 | 0.529 |
| R-HSA-8939211 | ESR-mediated signaling | 3.001858e-01 | 0.523 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.010887e-01 | 0.521 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.010887e-01 | 0.521 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.010887e-01 | 0.521 |
| R-HSA-165159 | MTOR signalling | 3.114594e-01 | 0.507 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.158878e-01 | 0.500 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.216775e-01 | 0.493 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.216775e-01 | 0.493 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.267300e-01 | 0.486 |
| R-HSA-774815 | Nucleosome assembly | 3.267300e-01 | 0.486 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.267300e-01 | 0.486 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.317452e-01 | 0.479 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.349425e-01 | 0.475 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.367233e-01 | 0.473 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 3.367233e-01 | 0.473 |
| R-HSA-9758941 | Gastrulation | 3.538447e-01 | 0.451 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.565305e-01 | 0.448 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.565305e-01 | 0.448 |
| R-HSA-72187 | mRNA 3'-end processing | 3.610677e-01 | 0.442 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.610677e-01 | 0.442 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.610677e-01 | 0.442 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.658291e-01 | 0.437 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.698994e-01 | 0.432 |
| R-HSA-72649 | Translation initiation complex formation | 3.705554e-01 | 0.431 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.799034e-01 | 0.420 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.799034e-01 | 0.420 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.799034e-01 | 0.420 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.845257e-01 | 0.415 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.853934e-01 | 0.414 |
| R-HSA-109581 | Apoptosis | 3.884318e-01 | 0.411 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.891137e-01 | 0.410 |
| R-HSA-9658195 | Leishmania infection | 3.894165e-01 | 0.410 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.894165e-01 | 0.410 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.936679e-01 | 0.405 |
| R-HSA-9033241 | Peroxisomal protein import | 3.936679e-01 | 0.405 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.981884e-01 | 0.400 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.981884e-01 | 0.400 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.026755e-01 | 0.395 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.026755e-01 | 0.395 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.071293e-01 | 0.390 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.071293e-01 | 0.390 |
| R-HSA-9707616 | Heme signaling | 4.071293e-01 | 0.390 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.115503e-01 | 0.386 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.119047e-01 | 0.385 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.144862e-01 | 0.382 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.159386e-01 | 0.381 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.202944e-01 | 0.376 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.202944e-01 | 0.376 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.246179e-01 | 0.372 |
| R-HSA-5218859 | Regulated Necrosis | 4.331694e-01 | 0.363 |
| R-HSA-168255 | Influenza Infection | 4.349336e-01 | 0.362 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.415948e-01 | 0.355 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.415948e-01 | 0.355 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.415948e-01 | 0.355 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.457608e-01 | 0.351 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.457608e-01 | 0.351 |
| R-HSA-8978934 | Metabolism of cofactors | 4.457608e-01 | 0.351 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.498960e-01 | 0.347 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.540006e-01 | 0.343 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.574774e-01 | 0.340 |
| R-HSA-8852135 | Protein ubiquitination | 4.621189e-01 | 0.335 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.673318e-01 | 0.330 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.722197e-01 | 0.326 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.740725e-01 | 0.324 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.818947e-01 | 0.317 |
| R-HSA-977225 | Amyloid fiber formation | 4.857625e-01 | 0.314 |
| R-HSA-597592 | Post-translational protein modification | 4.864361e-01 | 0.313 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.896016e-01 | 0.310 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.934123e-01 | 0.307 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 4.971948e-01 | 0.303 |
| R-HSA-72172 | mRNA Splicing | 4.986199e-01 | 0.302 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.009493e-01 | 0.300 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.009493e-01 | 0.300 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.046760e-01 | 0.297 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.126122e-01 | 0.290 |
| R-HSA-156902 | Peptide chain elongation | 5.156912e-01 | 0.288 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.195916e-01 | 0.284 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.264635e-01 | 0.279 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.300012e-01 | 0.276 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.335126e-01 | 0.273 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.438917e-01 | 0.264 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.457614e-01 | 0.263 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.473003e-01 | 0.262 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.473003e-01 | 0.262 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.473003e-01 | 0.262 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.506836e-01 | 0.259 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.532384e-01 | 0.257 |
| R-HSA-168249 | Innate Immune System | 5.553930e-01 | 0.255 |
| R-HSA-190236 | Signaling by FGFR | 5.573751e-01 | 0.254 |
| R-HSA-3214847 | HATs acetylate histones | 5.606837e-01 | 0.251 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.606837e-01 | 0.251 |
| R-HSA-72312 | rRNA processing | 5.619293e-01 | 0.250 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.672275e-01 | 0.246 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.672275e-01 | 0.246 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.704631e-01 | 0.244 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.704631e-01 | 0.244 |
| R-HSA-192823 | Viral mRNA Translation | 5.736747e-01 | 0.241 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.768624e-01 | 0.239 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.768624e-01 | 0.239 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.800265e-01 | 0.237 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.800265e-01 | 0.237 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.893788e-01 | 0.230 |
| R-HSA-211000 | Gene Silencing by RNA | 5.893788e-01 | 0.230 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.937430e-01 | 0.226 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.954986e-01 | 0.225 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.045091e-01 | 0.219 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.045091e-01 | 0.219 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.247670e-01 | 0.204 |
| R-HSA-68875 | Mitotic Prophase | 6.331307e-01 | 0.199 |
| R-HSA-73886 | Chromosome Maintenance | 6.358773e-01 | 0.197 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.413095e-01 | 0.193 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.493075e-01 | 0.188 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.493075e-01 | 0.188 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.493075e-01 | 0.188 |
| R-HSA-69206 | G1/S Transition | 6.493075e-01 | 0.188 |
| R-HSA-114608 | Platelet degranulation | 6.545410e-01 | 0.184 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.571286e-01 | 0.182 |
| R-HSA-9909396 | Circadian clock | 6.697811e-01 | 0.174 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.722555e-01 | 0.172 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.867204e-01 | 0.163 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.913999e-01 | 0.160 |
| R-HSA-9664407 | Parasite infection | 6.913999e-01 | 0.160 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.913999e-01 | 0.160 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.005520e-01 | 0.155 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.072389e-01 | 0.150 |
| R-HSA-69242 | S Phase | 7.116144e-01 | 0.148 |
| R-HSA-166520 | Signaling by NTRKs | 7.116144e-01 | 0.148 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.159250e-01 | 0.145 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.201717e-01 | 0.143 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.201717e-01 | 0.143 |
| R-HSA-69306 | DNA Replication | 7.222714e-01 | 0.141 |
| R-HSA-9609507 | Protein localization | 7.222714e-01 | 0.141 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.243555e-01 | 0.140 |
| R-HSA-73887 | Death Receptor Signaling | 7.243555e-01 | 0.140 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.273289e-01 | 0.138 |
| R-HSA-9711097 | Cellular response to starvation | 7.325378e-01 | 0.135 |
| R-HSA-1474244 | Extracellular matrix organization | 7.390231e-01 | 0.131 |
| R-HSA-392499 | Metabolism of proteins | 7.415750e-01 | 0.130 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.443617e-01 | 0.128 |
| R-HSA-418555 | G alpha (s) signalling events | 7.593242e-01 | 0.120 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.611324e-01 | 0.119 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.629271e-01 | 0.118 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.629271e-01 | 0.118 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.629271e-01 | 0.118 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.637914e-01 | 0.117 |
| R-HSA-2559583 | Cellular Senescence | 7.751210e-01 | 0.111 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.007068e-01 | 0.097 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.066384e-01 | 0.093 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.109719e-01 | 0.091 |
| R-HSA-1643685 | Disease | 8.149533e-01 | 0.089 |
| R-HSA-418990 | Adherens junctions interactions | 8.325080e-01 | 0.080 |
| R-HSA-72766 | Translation | 8.516672e-01 | 0.070 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.549415e-01 | 0.068 |
| R-HSA-421270 | Cell-cell junction organization | 8.695396e-01 | 0.061 |
| R-HSA-5688426 | Deubiquitination | 8.734361e-01 | 0.059 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.743920e-01 | 0.058 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.904247e-01 | 0.050 |
| R-HSA-446728 | Cell junction organization | 8.937021e-01 | 0.049 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.937021e-01 | 0.049 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.968822e-01 | 0.047 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.116824e-01 | 0.040 |
| R-HSA-1500931 | Cell-Cell communication | 9.203707e-01 | 0.036 |
| R-HSA-9679506 | SARS-CoV Infections | 9.311006e-01 | 0.031 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.447701e-01 | 0.025 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.525951e-01 | 0.021 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.564193e-01 | 0.019 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.574080e-01 | 0.019 |
| R-HSA-8978868 | Fatty acid metabolism | 9.605460e-01 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 9.833789e-01 | 0.007 |
| R-HSA-211859 | Biological oxidations | 9.838197e-01 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 9.902849e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.905202e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.922410e-01 | 0.003 |
| R-HSA-74160 | Gene expression (Transcription) | 9.980218e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.993561e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.995514e-01 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.999793e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999926e-01 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 9.999956e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.818 | 0.125 | 2 | 0.700 |
CLK3 |
0.811 | 0.151 | 1 | 0.770 |
ERK5 |
0.808 | 0.245 | 1 | 0.862 |
MST4 |
0.803 | 0.195 | 2 | 0.787 |
CDC7 |
0.802 | 0.047 | 1 | 0.743 |
MTOR |
0.801 | 0.011 | 1 | 0.745 |
PIM3 |
0.801 | 0.041 | -3 | 0.738 |
PRPK |
0.800 | -0.020 | -1 | 0.771 |
CDKL5 |
0.799 | 0.122 | -3 | 0.685 |
NLK |
0.798 | 0.060 | 1 | 0.781 |
DSTYK |
0.798 | 0.014 | 2 | 0.712 |
NDR2 |
0.797 | 0.066 | -3 | 0.742 |
ULK2 |
0.797 | -0.048 | 2 | 0.629 |
HIPK4 |
0.797 | 0.102 | 1 | 0.783 |
MOS |
0.797 | 0.026 | 1 | 0.790 |
NEK6 |
0.796 | 0.040 | -2 | 0.799 |
GCN2 |
0.795 | -0.070 | 2 | 0.638 |
CDKL1 |
0.795 | 0.031 | -3 | 0.696 |
SRPK1 |
0.794 | 0.069 | -3 | 0.650 |
CDK5 |
0.793 | 0.129 | 1 | 0.658 |
PRKD1 |
0.792 | 0.038 | -3 | 0.707 |
ATR |
0.791 | -0.013 | 1 | 0.771 |
RAF1 |
0.791 | -0.081 | 1 | 0.759 |
CHAK2 |
0.791 | 0.021 | -1 | 0.723 |
BMPR2 |
0.791 | -0.092 | -2 | 0.829 |
PKCD |
0.791 | 0.045 | 2 | 0.650 |
TBK1 |
0.790 | -0.076 | 1 | 0.670 |
PDHK4 |
0.790 | -0.150 | 1 | 0.787 |
PIM1 |
0.790 | 0.042 | -3 | 0.682 |
RSK2 |
0.790 | 0.027 | -3 | 0.675 |
IKKB |
0.790 | -0.085 | -2 | 0.735 |
CDK8 |
0.789 | 0.064 | 1 | 0.623 |
PKR |
0.789 | 0.189 | 1 | 0.800 |
NUAK2 |
0.789 | 0.018 | -3 | 0.747 |
WNK1 |
0.789 | 0.015 | -2 | 0.843 |
CAMK2G |
0.789 | -0.084 | 2 | 0.629 |
NIK |
0.788 | -0.021 | -3 | 0.797 |
PRKD2 |
0.788 | 0.025 | -3 | 0.669 |
CAMK1B |
0.788 | -0.066 | -3 | 0.776 |
MLK1 |
0.788 | -0.033 | 2 | 0.680 |
IKKA |
0.788 | 0.007 | -2 | 0.730 |
PDHK1 |
0.787 | -0.068 | 1 | 0.764 |
NEK9 |
0.787 | -0.000 | 2 | 0.707 |
NDR1 |
0.787 | 0.004 | -3 | 0.737 |
ICK |
0.787 | 0.043 | -3 | 0.733 |
JNK2 |
0.787 | 0.114 | 1 | 0.592 |
CDK19 |
0.786 | 0.072 | 1 | 0.591 |
P38A |
0.786 | 0.121 | 1 | 0.713 |
MLK3 |
0.786 | 0.039 | 2 | 0.619 |
CDK1 |
0.786 | 0.100 | 1 | 0.601 |
NEK7 |
0.785 | -0.082 | -3 | 0.746 |
PKN3 |
0.785 | -0.047 | -3 | 0.722 |
KIS |
0.785 | 0.052 | 1 | 0.667 |
MLK2 |
0.784 | -0.016 | 2 | 0.673 |
PKN2 |
0.784 | -0.014 | -3 | 0.739 |
RSK3 |
0.784 | 0.008 | -3 | 0.662 |
FAM20C |
0.784 | 0.026 | 2 | 0.460 |
PKCB |
0.783 | 0.043 | 2 | 0.617 |
IKKE |
0.783 | -0.116 | 1 | 0.657 |
LATS2 |
0.783 | -0.007 | -5 | 0.752 |
ULK1 |
0.783 | -0.131 | -3 | 0.746 |
SRPK2 |
0.783 | 0.033 | -3 | 0.566 |
SKMLCK |
0.783 | -0.040 | -2 | 0.797 |
P90RSK |
0.783 | -0.018 | -3 | 0.674 |
CDK13 |
0.782 | 0.062 | 1 | 0.620 |
JNK3 |
0.782 | 0.085 | 1 | 0.628 |
TGFBR2 |
0.782 | -0.040 | -2 | 0.693 |
CDK3 |
0.782 | 0.129 | 1 | 0.545 |
AMPKA1 |
0.782 | -0.034 | -3 | 0.757 |
P38B |
0.782 | 0.107 | 1 | 0.649 |
PKCA |
0.782 | 0.040 | 2 | 0.615 |
CAMLCK |
0.781 | -0.055 | -2 | 0.799 |
IRE1 |
0.781 | 0.008 | 1 | 0.781 |
HUNK |
0.781 | -0.105 | 2 | 0.634 |
MARK4 |
0.781 | -0.052 | 4 | 0.749 |
DYRK2 |
0.781 | 0.043 | 1 | 0.706 |
NIM1 |
0.781 | -0.027 | 3 | 0.720 |
GRK5 |
0.781 | -0.133 | -3 | 0.792 |
P70S6KB |
0.780 | -0.004 | -3 | 0.699 |
CAMK2D |
0.780 | -0.052 | -3 | 0.733 |
AURC |
0.780 | 0.044 | -2 | 0.583 |
ERK1 |
0.780 | 0.088 | 1 | 0.635 |
IRE2 |
0.779 | 0.006 | 2 | 0.611 |
TSSK1 |
0.778 | 0.002 | -3 | 0.781 |
P38G |
0.778 | 0.079 | 1 | 0.523 |
CDK2 |
0.778 | 0.076 | 1 | 0.665 |
CDK7 |
0.778 | 0.037 | 1 | 0.640 |
BMPR1B |
0.778 | 0.055 | 1 | 0.697 |
P38D |
0.778 | 0.105 | 1 | 0.550 |
BCKDK |
0.778 | -0.098 | -1 | 0.706 |
DAPK2 |
0.777 | -0.088 | -3 | 0.774 |
LATS1 |
0.777 | 0.001 | -3 | 0.769 |
AMPKA2 |
0.777 | -0.029 | -3 | 0.722 |
PKCG |
0.777 | 0.009 | 2 | 0.605 |
MAPKAPK3 |
0.777 | -0.052 | -3 | 0.663 |
GRK6 |
0.777 | -0.065 | 1 | 0.735 |
MAPKAPK2 |
0.777 | -0.009 | -3 | 0.622 |
CDK18 |
0.777 | 0.064 | 1 | 0.582 |
RIPK3 |
0.777 | -0.126 | 3 | 0.640 |
CLK2 |
0.776 | 0.077 | -3 | 0.663 |
WNK3 |
0.776 | -0.160 | 1 | 0.758 |
HIPK2 |
0.776 | 0.077 | 1 | 0.619 |
NEK2 |
0.776 | -0.020 | 2 | 0.675 |
PKACG |
0.775 | -0.031 | -2 | 0.677 |
PKCZ |
0.775 | -0.011 | 2 | 0.637 |
SRPK3 |
0.775 | 0.023 | -3 | 0.615 |
NUAK1 |
0.774 | -0.021 | -3 | 0.696 |
TSSK2 |
0.774 | -0.084 | -5 | 0.749 |
YSK4 |
0.774 | -0.054 | 1 | 0.695 |
GRK1 |
0.774 | -0.050 | -2 | 0.686 |
HIPK1 |
0.774 | 0.066 | 1 | 0.714 |
CDK12 |
0.774 | 0.053 | 1 | 0.596 |
VRK2 |
0.774 | -0.033 | 1 | 0.816 |
MLK4 |
0.773 | -0.036 | 2 | 0.582 |
DLK |
0.773 | -0.177 | 1 | 0.745 |
MASTL |
0.773 | -0.236 | -2 | 0.777 |
PAK1 |
0.773 | -0.040 | -2 | 0.734 |
CDK9 |
0.773 | 0.039 | 1 | 0.630 |
TGFBR1 |
0.772 | -0.006 | -2 | 0.721 |
CHAK1 |
0.772 | -0.051 | 2 | 0.617 |
MNK2 |
0.772 | -0.024 | -2 | 0.752 |
MELK |
0.772 | -0.044 | -3 | 0.705 |
RSK4 |
0.772 | 0.005 | -3 | 0.640 |
PIM2 |
0.772 | 0.039 | -3 | 0.644 |
CLK1 |
0.772 | 0.031 | -3 | 0.655 |
ALK4 |
0.771 | -0.046 | -2 | 0.754 |
MPSK1 |
0.771 | 0.112 | 1 | 0.768 |
SMG1 |
0.771 | -0.032 | 1 | 0.733 |
TLK2 |
0.771 | 0.006 | 1 | 0.735 |
MST3 |
0.771 | 0.082 | 2 | 0.715 |
ERK2 |
0.771 | 0.042 | 1 | 0.670 |
ERK7 |
0.771 | 0.051 | 2 | 0.434 |
CAMK2B |
0.771 | -0.052 | 2 | 0.601 |
PAK3 |
0.770 | -0.067 | -2 | 0.743 |
PKCH |
0.770 | -0.027 | 2 | 0.595 |
GRK7 |
0.770 | 0.001 | 1 | 0.684 |
DNAPK |
0.770 | -0.009 | 1 | 0.661 |
ANKRD3 |
0.770 | -0.178 | 1 | 0.795 |
CLK4 |
0.770 | 0.002 | -3 | 0.675 |
PRKD3 |
0.769 | -0.036 | -3 | 0.639 |
CDK17 |
0.769 | 0.043 | 1 | 0.526 |
PKACB |
0.769 | 0.010 | -2 | 0.606 |
AKT2 |
0.769 | 0.011 | -3 | 0.588 |
PRP4 |
0.769 | 0.043 | -3 | 0.724 |
PDHK3_TYR |
0.769 | 0.124 | 4 | 0.835 |
RIPK1 |
0.769 | -0.179 | 1 | 0.784 |
PLK1 |
0.768 | -0.113 | -2 | 0.745 |
ATM |
0.768 | -0.069 | 1 | 0.705 |
PHKG1 |
0.767 | -0.056 | -3 | 0.724 |
CAMK2A |
0.767 | -0.066 | 2 | 0.607 |
BRAF |
0.767 | -0.045 | -4 | 0.738 |
DCAMKL1 |
0.767 | -0.009 | -3 | 0.691 |
TAO3 |
0.767 | 0.041 | 1 | 0.722 |
TTBK2 |
0.767 | -0.174 | 2 | 0.552 |
SGK3 |
0.766 | -0.008 | -3 | 0.650 |
MNK1 |
0.766 | -0.033 | -2 | 0.764 |
PAK6 |
0.766 | -0.006 | -2 | 0.666 |
NEK5 |
0.766 | -0.019 | 1 | 0.795 |
QSK |
0.766 | -0.058 | 4 | 0.723 |
GRK4 |
0.765 | -0.168 | -2 | 0.727 |
MEK1 |
0.765 | -0.182 | 2 | 0.651 |
MEKK1 |
0.765 | -0.069 | 1 | 0.737 |
EEF2K |
0.765 | 0.123 | 3 | 0.858 |
TNIK |
0.765 | 0.144 | 3 | 0.870 |
MEKK2 |
0.765 | -0.026 | 2 | 0.651 |
HIPK3 |
0.765 | 0.035 | 1 | 0.717 |
SIK |
0.765 | -0.052 | -3 | 0.657 |
IRAK4 |
0.765 | -0.031 | 1 | 0.781 |
LKB1 |
0.765 | 0.080 | -3 | 0.736 |
AURB |
0.765 | -0.013 | -2 | 0.582 |
PERK |
0.765 | -0.045 | -2 | 0.754 |
CDK16 |
0.764 | 0.063 | 1 | 0.543 |
PINK1 |
0.764 | -0.071 | 1 | 0.789 |
PRKX |
0.764 | 0.016 | -3 | 0.586 |
QIK |
0.764 | -0.118 | -3 | 0.729 |
CDK10 |
0.763 | 0.069 | 1 | 0.610 |
ALK2 |
0.763 | -0.024 | -2 | 0.720 |
PKG2 |
0.763 | -0.018 | -2 | 0.616 |
ACVR2B |
0.763 | -0.043 | -2 | 0.717 |
CHK1 |
0.763 | -0.077 | -3 | 0.729 |
WNK4 |
0.763 | -0.047 | -2 | 0.845 |
HRI |
0.763 | -0.093 | -2 | 0.781 |
DYRK1A |
0.763 | 0.007 | 1 | 0.708 |
CAMKK1 |
0.762 | 0.005 | -2 | 0.772 |
PLK3 |
0.762 | -0.099 | 2 | 0.569 |
MSK2 |
0.762 | -0.101 | -3 | 0.619 |
HGK |
0.762 | 0.095 | 3 | 0.860 |
MAK |
0.762 | 0.111 | -2 | 0.742 |
PKCT |
0.761 | -0.021 | 2 | 0.608 |
ACVR2A |
0.761 | -0.050 | -2 | 0.697 |
MOK |
0.761 | 0.116 | 1 | 0.789 |
GSK3A |
0.761 | 0.029 | 4 | 0.443 |
ZAK |
0.760 | -0.106 | 1 | 0.693 |
BMPR1A |
0.760 | 0.034 | 1 | 0.658 |
LIMK2_TYR |
0.760 | 0.095 | -3 | 0.807 |
CDK6 |
0.760 | 0.073 | 1 | 0.602 |
TAO2 |
0.760 | 0.013 | 2 | 0.707 |
CAMK4 |
0.760 | -0.162 | -3 | 0.722 |
TESK1_TYR |
0.760 | -0.015 | 3 | 0.845 |
MAP2K4_TYR |
0.759 | 0.035 | -1 | 0.800 |
AKT1 |
0.759 | 0.001 | -3 | 0.604 |
MINK |
0.759 | 0.074 | 1 | 0.732 |
GAK |
0.759 | 0.050 | 1 | 0.789 |
MARK3 |
0.759 | -0.072 | 4 | 0.675 |
PKCI |
0.758 | -0.013 | 2 | 0.617 |
CAMKK2 |
0.758 | 0.006 | -2 | 0.769 |
CDK14 |
0.758 | 0.018 | 1 | 0.618 |
JNK1 |
0.758 | 0.047 | 1 | 0.572 |
BRSK1 |
0.758 | -0.106 | -3 | 0.686 |
PAK2 |
0.758 | -0.112 | -2 | 0.716 |
PLK4 |
0.758 | -0.123 | 2 | 0.466 |
MARK2 |
0.758 | -0.087 | 4 | 0.644 |
MEK5 |
0.757 | -0.193 | 2 | 0.661 |
CDK4 |
0.757 | 0.060 | 1 | 0.581 |
AURA |
0.757 | -0.031 | -2 | 0.541 |
GCK |
0.757 | 0.030 | 1 | 0.731 |
DYRK1B |
0.757 | 0.006 | 1 | 0.642 |
PHKG2 |
0.757 | -0.035 | -3 | 0.715 |
MAP2K6_TYR |
0.756 | -0.040 | -1 | 0.799 |
PDHK4_TYR |
0.756 | -0.040 | 2 | 0.690 |
DYRK4 |
0.756 | 0.008 | 1 | 0.619 |
MSK1 |
0.756 | -0.076 | -3 | 0.629 |
PKMYT1_TYR |
0.756 | -0.001 | 3 | 0.794 |
KHS1 |
0.756 | 0.095 | 1 | 0.724 |
BRSK2 |
0.756 | -0.124 | -3 | 0.715 |
PKCE |
0.755 | 0.013 | 2 | 0.603 |
GSK3B |
0.755 | -0.013 | 4 | 0.432 |
MEKK3 |
0.755 | -0.175 | 1 | 0.738 |
DRAK1 |
0.755 | -0.132 | 1 | 0.694 |
DYRK3 |
0.755 | -0.005 | 1 | 0.725 |
P70S6K |
0.755 | -0.023 | -3 | 0.592 |
KHS2 |
0.754 | 0.101 | 1 | 0.730 |
MST2 |
0.754 | -0.021 | 1 | 0.733 |
MYLK4 |
0.754 | -0.099 | -2 | 0.702 |
NEK8 |
0.754 | -0.105 | 2 | 0.674 |
MEKK6 |
0.754 | 0.008 | 1 | 0.744 |
NEK4 |
0.753 | -0.033 | 1 | 0.747 |
BMPR2_TYR |
0.753 | -0.039 | -1 | 0.774 |
TLK1 |
0.753 | -0.108 | -2 | 0.736 |
NEK1 |
0.753 | 0.030 | 1 | 0.764 |
MAP2K7_TYR |
0.753 | -0.185 | 2 | 0.684 |
SNRK |
0.752 | -0.197 | 2 | 0.518 |
PKACA |
0.752 | -0.020 | -2 | 0.556 |
DCAMKL2 |
0.752 | -0.079 | -3 | 0.724 |
PINK1_TYR |
0.751 | -0.104 | 1 | 0.780 |
YSK1 |
0.751 | 0.056 | 2 | 0.702 |
PDHK1_TYR |
0.751 | -0.084 | -1 | 0.791 |
LOK |
0.751 | 0.012 | -2 | 0.747 |
HPK1 |
0.751 | 0.021 | 1 | 0.720 |
CAMK1G |
0.751 | -0.109 | -3 | 0.658 |
LRRK2 |
0.750 | -0.044 | 2 | 0.691 |
CK1E |
0.750 | -0.061 | -3 | 0.505 |
CK2A2 |
0.750 | 0.018 | 1 | 0.613 |
SSTK |
0.750 | -0.096 | 4 | 0.707 |
AKT3 |
0.750 | 0.006 | -3 | 0.517 |
PDK1 |
0.750 | -0.076 | 1 | 0.760 |
MAP3K15 |
0.750 | -0.043 | 1 | 0.691 |
PASK |
0.750 | -0.085 | -3 | 0.744 |
GRK2 |
0.750 | -0.113 | -2 | 0.635 |
MARK1 |
0.750 | -0.120 | 4 | 0.693 |
PBK |
0.749 | 0.058 | 1 | 0.739 |
NEK11 |
0.748 | -0.154 | 1 | 0.725 |
TNNI3K_TYR |
0.748 | 0.091 | 1 | 0.785 |
CK1G1 |
0.748 | -0.050 | -3 | 0.523 |
LIMK1_TYR |
0.748 | -0.096 | 2 | 0.695 |
SMMLCK |
0.747 | -0.112 | -3 | 0.715 |
EPHA6 |
0.747 | -0.020 | -1 | 0.738 |
TAK1 |
0.747 | -0.069 | 1 | 0.744 |
BUB1 |
0.747 | 0.034 | -5 | 0.688 |
MAPKAPK5 |
0.747 | -0.156 | -3 | 0.584 |
MST1 |
0.747 | -0.029 | 1 | 0.722 |
VRK1 |
0.746 | -0.083 | 2 | 0.673 |
ABL2 |
0.746 | 0.029 | -1 | 0.703 |
TYK2 |
0.746 | -0.069 | 1 | 0.739 |
SGK1 |
0.745 | -0.007 | -3 | 0.500 |
ROS1 |
0.745 | -0.063 | 3 | 0.702 |
PKN1 |
0.744 | -0.051 | -3 | 0.615 |
MYO3B |
0.744 | 0.089 | 2 | 0.699 |
RET |
0.744 | -0.135 | 1 | 0.743 |
PAK5 |
0.744 | -0.062 | -2 | 0.586 |
ROCK2 |
0.743 | 0.003 | -3 | 0.685 |
NEK3 |
0.743 | 0.009 | 1 | 0.718 |
ABL1 |
0.743 | 0.028 | -1 | 0.694 |
EPHB4 |
0.743 | -0.050 | -1 | 0.719 |
FGR |
0.743 | -0.015 | 1 | 0.813 |
TYRO3 |
0.743 | -0.100 | 3 | 0.740 |
MRCKB |
0.742 | -0.009 | -3 | 0.637 |
IRAK1 |
0.741 | -0.226 | -1 | 0.637 |
MRCKA |
0.740 | -0.012 | -3 | 0.654 |
CAMK1D |
0.740 | -0.096 | -3 | 0.580 |
PLK2 |
0.740 | -0.052 | -3 | 0.750 |
JAK2 |
0.740 | -0.112 | 1 | 0.732 |
OSR1 |
0.739 | 0.007 | 2 | 0.659 |
SLK |
0.739 | -0.070 | -2 | 0.675 |
DAPK3 |
0.739 | -0.081 | -3 | 0.704 |
CK1D |
0.739 | -0.072 | -3 | 0.459 |
MST1R |
0.738 | -0.153 | 3 | 0.726 |
PAK4 |
0.737 | -0.071 | -2 | 0.583 |
DDR1 |
0.737 | -0.151 | 4 | 0.744 |
NEK10_TYR |
0.737 | -0.044 | 1 | 0.626 |
CK2A1 |
0.737 | -0.010 | 1 | 0.589 |
MYO3A |
0.737 | 0.039 | 1 | 0.735 |
YES1 |
0.737 | -0.070 | -1 | 0.720 |
JAK1 |
0.736 | -0.031 | 1 | 0.680 |
STK33 |
0.736 | -0.135 | 2 | 0.458 |
TNK2 |
0.736 | -0.053 | 3 | 0.661 |
TTBK1 |
0.736 | -0.201 | 2 | 0.480 |
JAK3 |
0.736 | -0.120 | 1 | 0.722 |
CK1A2 |
0.735 | -0.075 | -3 | 0.453 |
LCK |
0.735 | 0.001 | -1 | 0.692 |
CSF1R |
0.735 | -0.145 | 3 | 0.694 |
TXK |
0.735 | -0.031 | 1 | 0.742 |
TNK1 |
0.735 | -0.070 | 3 | 0.714 |
GRK3 |
0.735 | -0.104 | -2 | 0.575 |
DMPK1 |
0.734 | 0.006 | -3 | 0.672 |
MEK2 |
0.734 | -0.184 | 2 | 0.645 |
SBK |
0.734 | -0.042 | -3 | 0.472 |
WEE1_TYR |
0.734 | -0.031 | -1 | 0.633 |
CHK2 |
0.734 | -0.076 | -3 | 0.534 |
FER |
0.733 | -0.134 | 1 | 0.790 |
HASPIN |
0.733 | -0.012 | -1 | 0.582 |
HCK |
0.732 | -0.075 | -1 | 0.697 |
ITK |
0.732 | -0.076 | -1 | 0.669 |
TAO1 |
0.731 | -0.021 | 1 | 0.663 |
BLK |
0.731 | -0.009 | -1 | 0.706 |
FLT3 |
0.730 | -0.140 | 3 | 0.731 |
EPHA4 |
0.730 | -0.113 | 2 | 0.574 |
DAPK1 |
0.730 | -0.100 | -3 | 0.680 |
INSRR |
0.730 | -0.153 | 3 | 0.662 |
ROCK1 |
0.729 | -0.023 | -3 | 0.650 |
BIKE |
0.729 | 0.013 | 1 | 0.689 |
CRIK |
0.729 | 0.005 | -3 | 0.596 |
PDGFRB |
0.728 | -0.185 | 3 | 0.725 |
CAMK1A |
0.728 | -0.096 | -3 | 0.552 |
TTK |
0.728 | -0.076 | -2 | 0.725 |
EPHB2 |
0.727 | -0.107 | -1 | 0.696 |
EPHB3 |
0.727 | -0.120 | -1 | 0.699 |
EPHB1 |
0.727 | -0.137 | 1 | 0.760 |
SRMS |
0.727 | -0.147 | 1 | 0.759 |
ASK1 |
0.726 | -0.114 | 1 | 0.671 |
BTK |
0.724 | -0.159 | -1 | 0.640 |
KDR |
0.723 | -0.177 | 3 | 0.645 |
FGFR2 |
0.723 | -0.219 | 3 | 0.697 |
KIT |
0.723 | -0.198 | 3 | 0.695 |
BMX |
0.723 | -0.092 | -1 | 0.597 |
PTK6 |
0.722 | -0.179 | -1 | 0.600 |
MERTK |
0.722 | -0.145 | 3 | 0.664 |
FGFR1 |
0.721 | -0.207 | 3 | 0.668 |
MET |
0.721 | -0.151 | 3 | 0.688 |
LTK |
0.721 | -0.127 | 3 | 0.645 |
PDGFRA |
0.721 | -0.236 | 3 | 0.730 |
AXL |
0.720 | -0.191 | 3 | 0.664 |
RIPK2 |
0.720 | -0.285 | 1 | 0.663 |
TEC |
0.720 | -0.131 | -1 | 0.602 |
PKG1 |
0.720 | -0.077 | -2 | 0.545 |
FYN |
0.719 | -0.065 | -1 | 0.661 |
ALK |
0.719 | -0.174 | 3 | 0.638 |
ALPHAK3 |
0.719 | -0.082 | -1 | 0.688 |
INSR |
0.719 | -0.144 | 3 | 0.644 |
TEK |
0.718 | -0.234 | 3 | 0.654 |
AAK1 |
0.718 | 0.053 | 1 | 0.604 |
DDR2 |
0.717 | -0.093 | 3 | 0.638 |
EPHA3 |
0.716 | -0.168 | 2 | 0.554 |
MATK |
0.716 | -0.129 | -1 | 0.645 |
NTRK1 |
0.715 | -0.225 | -1 | 0.714 |
LYN |
0.715 | -0.113 | 3 | 0.626 |
FRK |
0.715 | -0.138 | -1 | 0.714 |
YANK3 |
0.715 | -0.101 | 2 | 0.283 |
NTRK2 |
0.714 | -0.206 | 3 | 0.648 |
EPHA7 |
0.714 | -0.156 | 2 | 0.574 |
FLT1 |
0.712 | -0.201 | -1 | 0.725 |
EPHA1 |
0.711 | -0.190 | 3 | 0.655 |
FGFR3 |
0.711 | -0.231 | 3 | 0.662 |
PTK2B |
0.711 | -0.130 | -1 | 0.638 |
CSK |
0.711 | -0.147 | 2 | 0.587 |
NTRK3 |
0.710 | -0.170 | -1 | 0.673 |
ERBB2 |
0.710 | -0.229 | 1 | 0.670 |
STLK3 |
0.708 | -0.181 | 1 | 0.661 |
SRC |
0.708 | -0.129 | -1 | 0.663 |
PTK2 |
0.708 | -0.070 | -1 | 0.676 |
FLT4 |
0.708 | -0.251 | 3 | 0.641 |
EPHA5 |
0.707 | -0.162 | 2 | 0.548 |
EGFR |
0.707 | -0.136 | 1 | 0.577 |
EPHA8 |
0.704 | -0.164 | -1 | 0.671 |
MUSK |
0.702 | -0.151 | 1 | 0.590 |
FGFR4 |
0.702 | -0.168 | -1 | 0.672 |
CK1A |
0.701 | -0.099 | -3 | 0.381 |
SYK |
0.701 | -0.106 | -1 | 0.674 |
IGF1R |
0.699 | -0.158 | 3 | 0.579 |
EPHA2 |
0.692 | -0.177 | -1 | 0.651 |
ERBB4 |
0.689 | -0.148 | 1 | 0.591 |
YANK2 |
0.683 | -0.117 | 2 | 0.291 |
CK1G3 |
0.682 | -0.112 | -3 | 0.338 |
FES |
0.680 | -0.199 | -1 | 0.571 |
ZAP70 |
0.680 | -0.122 | -1 | 0.605 |
CK1G2 |
0.654 | -0.137 | -3 | 0.433 |