Motif 63 (n=174)

Position-wise Probabilities

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uniprot genes site source protein function
A4UGR9 XIRP2 S2996 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
A6NC98 CCDC88B S514 ochoa Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}.
A6ND36 FAM83G S666 ochoa Protein FAM83G (Protein associated with SMAD1) Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}.
A6NHR9 SMCHD1 S1974 ochoa Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}.
A6NIX2 WTIP S29 ochoa Wilms tumor protein 1-interacting protein (WT1-interacting protein) Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
A7KAX9 ARHGAP32 S871 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
E7EW31 PROB1 S470 ochoa Proline-rich basic protein 1 None
O00592 PODXL S122 ochoa Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.
O14524 NEMP1 S368 ochoa Nuclear envelope integral membrane protein 1 Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (By similarity). Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity). {ECO:0000250|UniProtKB:Q6ZQE4, ECO:0000269|PubMed:32923640}.
O14686 KMT2D S2640 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14976 GAK S456 ochoa Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
O14978 ZNF263 S166 ochoa Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}.
O15085 ARHGEF11 S255 ochoa Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
O15164 TRIM24 S811 ochoa Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.
O15169 AXIN1 S486 ochoa Axin-1 (Axis inhibition protein 1) (hAxin) Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}.
O15231 ZNF185 S307 ochoa Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) May be involved in the regulation of cellular proliferation and/or differentiation.
O43299 AP5Z1 S732 ochoa AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.
O43521 BCL2L11 S104 psp Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}.
O43526 KCNQ2 S476 ochoa|psp Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}.
O43680 TCF21 S67 ochoa Transcription factor 21 (TCF-21) (Capsulin) (Class A basic helix-loop-helix protein 23) (bHLHa23) (Epicardin) (Podocyte-expressed 1) (Pod-1) Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
O60292 SIPA1L3 S1559 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75161 NPHP4 S142 ochoa Nephrocystin-4 (Nephroretinin) Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}.
O75362 ZNF217 S407 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O75369 FLNB S341 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75467 ZNF324 S164 ochoa Zinc finger protein 324A (Zinc finger protein ZF5128) May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. {ECO:0000305|PubMed:11779640}.
O75691 UTP20 S843 ochoa Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}.
O94988 FAM13A S856 ochoa Protein FAM13A None
O95340 PAPSS2 S92 ochoa Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708). {ECO:0000269|PubMed:11773860, ECO:0000269|PubMed:19474428, ECO:0000269|PubMed:23824674, ECO:0000269|PubMed:25594860, ECO:0000269|PubMed:9771708}.
O96028 NSD2 S437 ochoa Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}.
P05023 ATP1A1 S694 ochoa Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P06401 PGR S162 ochoa|psp Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
P07101 TH S502 ochoa Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.
P08151 GLI1 S968 psp Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P09543 CNP S318 ochoa 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}.
P0C7T5 ATXN1L S361 ochoa Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}.
P10644 PRKAR1A S83 ochoa|psp cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.
P11441 UBL4A S90 ochoa Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}.
P11940 PABPC1 S434 ochoa Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
P13639 EEF2 S595 ochoa|psp Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P13994 YJU2B S306 ochoa Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}.
P17861 XBP1 S68 ochoa|psp X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}.
P18031 PTPN1 S50 ochoa|psp Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P18887 XRCC1 S199 ochoa DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}.
P19971 TYMP S364 ochoa Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}.
P21333 FLNA S368 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P31269 HOXA9 S161 ochoa Homeobox protein Hox-A9 (Homeobox protein Hox-1G) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}.
P31321 PRKAR1B S83 ochoa cAMP-dependent protein kinase type I-beta regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}.
P37275 ZEB1 S704 ochoa Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
P42356 PI4KA S429 ochoa Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.
P42568 MLLT3 S483 ochoa Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.
P48552 NRIP1 S218 ochoa Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.
P48637 GSS S137 ochoa Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}.
P49715 CEBPA S21 ochoa|psp CCAAT/enhancer-binding protein alpha (C/EBP alpha) Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}.
P50570 DNM2 S764 ochoa|psp Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}.
P50851 LRBA S1498 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51114 FXR1 S496 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P51610 HCFC1 S757 ochoa Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}.
P53567 CEBPG S56 ochoa CCAAT/enhancer-binding protein gamma (C/EBP gamma) Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}.
P53602 MVD S222 ochoa Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}.
P53814 SMTN S514 ochoa Smoothelin Structural protein of the cytoskeleton.
P54253 ATXN1 S88 ochoa Ataxin-1 (Spinocerebellar ataxia type 1 protein) Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}.
P55064 AQP5 S183 psp Aquaporin-5 (AQP-5) Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:18768791, PubMed:8621489). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). {ECO:0000250|UniProtKB:Q9WTY4, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:8621489}.
P56524 HDAC4 S611 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P98194 ATP2C1 S621 ochoa Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}.
Q05519 SRSF11 S70 ochoa Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) May function in pre-mRNA splicing.
Q09472 EP300 S1726 ochoa Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.
Q12770 SCAP S907 ochoa Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}.
Q12789 GTF3C1 S1856 ochoa General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Q13017 ARHGAP5 S765 ochoa Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}.
Q13085 ACACA S488 ochoa Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.
Q13415 ORC1 S199 ochoa Origin recognition complex subunit 1 (Replication control protein 1) Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Q14135 VGLL4 S149 ochoa Transcription cofactor vestigial-like protein 4 (Vgl-4) May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}.
Q14197 MRPL58 Y49 ochoa Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29) Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294). {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:33878294}.
Q14558 PRPSAP1 S177 ochoa Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
Q14956 GPNMB S531 ochoa Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) Could be a melanogenic enzyme. {ECO:0000250}.
Q14980 NUMA1 S77 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15036 SNX17 S434 ochoa Sorting nexin-17 Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}.
Q155Q3 DIXDC1 S74 ochoa Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}.
Q15717 ELAVL1 S221 psp ELAV-like protein 1 (Hu-antigen R) (HuR) RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}.
Q15797 SMAD1 S151 ochoa Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.
Q27J81 INF2 S372 ochoa Inverted formin-2 (HBEBP2-binding protein C) Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.
Q2KJY2 KIF26B S1613 ochoa Kinesin-like protein KIF26B Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.
Q2LD37 BLTP1 S4308 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q2M2Z5 KIZ S179 ochoa Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}.
Q3B820 FAM161A S396 ochoa Protein FAM161A Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}.
Q3KR37 GRAMD1B S550 ochoa Protein Aster-B (GRAM domain-containing protein 1B) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}.
Q49A88 CCDC14 S798 ochoa Coiled-coil domain-containing protein 14 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.
Q5BKX5 ACTMAP S316 ochoa Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}.
Q5JTD0 TJAP1 S214 ochoa Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}.
Q5T8I9 HENMT1 S329 ochoa Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}.
Q5VWN6 TASOR2 S384 ochoa Protein TASOR 2 None
Q5VZ89 DENND4C S741 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q68CZ2 TNS3 S976 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68D85 NCR3LG1 S397 ochoa Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}.
Q68DA7 FMN1 S842 ochoa Formin-1 (Limb deformity protein homolog) Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.
Q6DT37 CDC42BPG S480 ochoa Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}.
Q6IQ26 DENND5A S1096 ochoa DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.
Q6NV74 CRACDL S185 ochoa CRACD-like protein None
Q6PJG6 BRAT1 S742 ochoa Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}.
Q6UB99 ANKRD11 S1509 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q76I76 SSH2 S1227 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q7L2J0 MEPCE S330 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q7Z340 ZNF551 S126 ochoa Zinc finger protein 551 (Zinc finger protein KOX23) May be involved in transcriptional regulation.
Q7Z401 DENND4A S731 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q8IUG5 MYO18B S2193 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IV31 TMEM139 S155 ochoa Transmembrane protein 139 May be involved in cellular trafficking of proteins such as SLC4A1. {ECO:0000305|PubMed:26049106}.
Q8IV32 CCDC71 S208 ochoa Coiled-coil domain-containing protein 71 None
Q8IV32 CCDC71 S264 ochoa Coiled-coil domain-containing protein 71 None
Q8IZD4 DCP1B S283 ochoa mRNA-decapping enzyme 1B (EC 3.6.1.62) May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}.
Q8IZD4 DCP1B S448 ochoa mRNA-decapping enzyme 1B (EC 3.6.1.62) May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}.
Q8IZE3 SCYL3 S707 ochoa Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}.
Q8N111 CEND1 S87 ochoa Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen) Involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9JKC6}.
Q8NBZ0 INO80E S154 ochoa|psp INO80 complex subunit E (Coiled-coil domain-containing protein 95) Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Q8NFH5 NUP35 S121 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8TED9 AFAP1L1 S149 ochoa Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}.
Q8TEW8 PARD3B S1184 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WYB5 KAT6B S371 ochoa Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.
Q92793 CREBBP S1763 ochoa CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q92879 CELF1 S179 ochoa|psp CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}.
Q96A22 C11orf52 S85 ochoa Uncharacterized protein C11orf52 None
Q96AC1 FERMT2 S523 ochoa Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
Q96CM3 RPUSD4 S221 ochoa Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677, ECO:0000269|PubMed:35051350}.
Q96CU9 FOXRED1 S189 ochoa FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.
Q96E22 NUS1 S168 ochoa Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466, ECO:0000269|PubMed:33077723}.
Q96HA7 TONSL S719 ochoa Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:27338793, PubMed:29478807). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30773278}.
Q96L91 EP400 S2476 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96N67 DOCK7 S864 ochoa Dedicator of cytokinesis protein 7 Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}.
Q96RG2 PASK S843 ochoa PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96RU2 USP28 S113 ochoa Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}.
Q99081 TCF12 S142 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99717 SMAD5 S152 ochoa Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}.
Q9BSI4 TINF2 S295 ochoa|psp TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}.
Q9BWE0 REPIN1 S27 ochoa DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}.
Q9BWF2 TRAIP S295 ochoa E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}.
Q9BWN1 PRR14 S162 ochoa Proline-rich protein 14 Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}.
Q9BY89 KIAA1671 S1312 ochoa Uncharacterized protein KIAA1671 None
Q9BYN7 ZNF341 S295 ochoa Zinc finger protein 341 Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. {ECO:0000269|PubMed:29907690, ECO:0000269|PubMed:29907691}.
Q9C0D5 TANC1 S85 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9C0K0 BCL11B S129 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H0F5 RNF38 S60 ochoa E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38) Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269|PubMed:23973461}.
Q9H116 GZF1 S265 ochoa GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}.
Q9H2M9 RAB3GAP2 S450 ochoa Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}.
Q9H706 GAREM1 S356 ochoa GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
Q9H9P5 UNKL S327 ochoa Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}.
Q9HAS0 C17orf75 S59 ochoa Protein Njmu-R1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}.
Q9HCC9 ZFYVE28 S523 ochoa Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}.
Q9HDC5 JPH1 S185 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NP73 ALG13 S830 ochoa UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:22492991}.; FUNCTION: [Isoform 2]: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:16100110, ECO:0000269|PubMed:36200043}.; FUNCTION: [Isoform 1]: No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme. {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36200043}.
Q9NS62 THSD1 S791 ochoa Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}.
Q9NYF5 FAM13B S760 ochoa Protein FAM13B (GAP-like protein N61) None
Q9NZC9 SMARCAL1 S652 psp SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}.
Q9P107 GMIP S243 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P203 BTBD7 S722 ochoa BTB/POZ domain-containing protein 7 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.
Q9P242 NYAP2 S379 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P2A4 ABI3 S161 ochoa ABI gene family member 3 (New molecule including SH3) (Nesh) May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}.
Q9UBT2 UBA2 S207 ochoa SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Q9UGP5 POLL S230 psp DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}.
Q9UGU0 TCF20 S871 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UIF8 BAZ2B S1680 ochoa Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}.
Q9UII2 ATP5IF1 S27 psp ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}.
Q9UIS9 MBD1 S37 ochoa Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}.
Q9UKK3 PARP4 S1335 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9UKL3 CASP8AP2 S20 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9ULD2 MTUS1 S752 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9UNZ2 NSFL1C S114 ochoa NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPU5 USP24 S1612 ochoa Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.
Q9Y286 SIGLEC7 S406 ochoa Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
Q9Y2H5 PLEKHA6 S384 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y4F3 MARF1 S827 ochoa Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Q9Y5A7 NUB1 S489 ochoa NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}.
Q9Y6X0 SETBP1 S611 ochoa SET-binding protein (SEB) None
O00444 PLK4 S499 Sugiyama Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
P17174 GOT1 S93 Sugiyama Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.
Q13164 MAPK7 S210 Sugiyama Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
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reactome_id name p -log10_p
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.000109 3.961
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.000199 3.700
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.000262 3.581
R-HSA-9018519 Estrogen-dependent gene expression 0.000641 3.193
R-HSA-163765 ChREBP activates metabolic gene expression 0.000716 3.145
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.002529 2.597
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.002529 2.597
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.003414 2.467
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.003414 2.467
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.004424 2.354
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.005470 2.262
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.005555 2.255
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.005555 2.255
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.007776 2.109
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.007776 2.109
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.007776 2.109
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.006804 2.167
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.009643 2.016
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.009643 2.016
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.011014 1.958
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.010024 1.999
R-HSA-8878159 Transcriptional regulation by RUNX3 0.010841 1.965
R-HSA-5467345 Deletions in the AXIN1 gene destabilize the destruction complex 0.012098 1.917
R-HSA-4839735 Signaling by AXIN mutants 0.014713 1.832
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.014713 1.832
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.014713 1.832
R-HSA-1234174 Cellular response to hypoxia 0.012670 1.897
R-HSA-3214847 HATs acetylate histones 0.011657 1.933
R-HSA-8939211 ESR-mediated signaling 0.014132 1.850
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.014713 1.832
R-HSA-8951936 RUNX3 regulates p14-ARF 0.016608 1.780
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.016608 1.780
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.016608 1.780
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.017127 1.766
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.018601 1.730
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.019155 1.718
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 0.018601 1.730
R-HSA-4839726 Chromatin organization 0.018043 1.744
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.018601 1.730
R-HSA-196780 Biotin transport and metabolism 0.022871 1.641
R-HSA-446353 Cell-extracellular matrix interactions 0.022871 1.641
R-HSA-198765 Signalling to ERK5 0.047526 1.323
R-HSA-3560796 Defective PAPSS2 causes SEMD-PA 0.047526 1.323
R-HSA-4755609 Defective DHDDS causes RP59 0.047526 1.323
R-HSA-5633231 Defective ALG14 causes ALG14-CMS 0.047526 1.323
R-HSA-111446 Activation of BIM and translocation to mitochondria 0.059052 1.229
R-HSA-5579006 Defective GSS causes GSS deficiency 0.059052 1.229
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.059052 1.229
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.059052 1.229
R-HSA-111463 SMAC (DIABLO) binds to IAPs 0.081690 1.088
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 0.081690 1.088
R-HSA-111469 SMAC, XIAP-regulated apoptotic response 0.092805 1.032
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 0.092805 1.032
R-HSA-8857538 PTK6 promotes HIF1A stabilization 0.103785 0.984
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.103785 0.984
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 0.114634 0.941
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.135941 0.867
R-HSA-9700645 ALK mutants bind TKIs 0.135941 0.867
R-HSA-350054 Notch-HLH transcription pathway 0.046284 1.335
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.156738 0.805
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.156738 0.805
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.156738 0.805
R-HSA-429947 Deadenylation of mRNA 0.052309 1.281
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.166948 0.777
R-HSA-202670 ERKs are inactivated 0.166948 0.777
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.166948 0.777
R-HSA-5339716 Signaling by GSK3beta mutants 0.166948 0.777
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.177036 0.752
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.177036 0.752
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.177036 0.752
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.177036 0.752
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.177036 0.752
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.177036 0.752
R-HSA-196299 Beta-catenin phosphorylation cascade 0.206576 0.685
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.235061 0.629
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.060571 1.218
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.262528 0.581
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.280292 0.552
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.331070 0.480
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.331070 0.480
R-HSA-171306 Packaging Of Telomere Ends 0.331070 0.480
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.355106 0.450
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.362926 0.440
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.362926 0.440
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.259042 0.587
R-HSA-383280 Nuclear Receptor transcription pathway 0.281483 0.551
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.299401 0.524
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.330565 0.481
R-HSA-381070 IRE1alpha activates chaperones 0.126398 0.898
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.339404 0.469
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.331070 0.480
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.289014 0.539
R-HSA-171319 Telomere Extension By Telomerase 0.339180 0.470
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.322862 0.491
R-HSA-68962 Activation of the pre-replicative complex 0.355106 0.450
R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.114634 0.941
R-HSA-190873 Gap junction degradation 0.135941 0.867
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.187003 0.728
R-HSA-174430 Telomere C-strand synthesis initiation 0.206576 0.685
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.225681 0.647
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 0.081690 1.088
R-HSA-8849472 PTK6 Down-Regulation 0.081690 1.088
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.033111 1.480
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.124533 0.905
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.314553 0.502
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.042765 1.369
R-HSA-5619507 Activation of HOX genes during differentiation 0.054421 1.264
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.054421 1.264
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.355106 0.450
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.086056 1.065
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.051112 1.291
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.051112 1.291
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.051112 1.291
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.051112 1.291
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.116537 0.934
R-HSA-198753 ERK/MAPK targets 0.271464 0.566
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.170521 0.768
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.245584 0.610
R-HSA-4791275 Signaling by WNT in cancer 0.078874 1.103
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 0.135941 0.867
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.149247 0.826
R-HSA-201451 Signaling by BMP 0.061833 1.209
R-HSA-381119 Unfolded Protein Response (UPR) 0.043153 1.365
R-HSA-8875513 MET interacts with TNS proteins 0.059052 1.229
R-HSA-68689 CDC6 association with the ORC:origin complex 0.092805 1.032
R-HSA-196025 Formation of annular gap junctions 0.125352 0.902
R-HSA-163615 PKA activation 0.032477 1.488
R-HSA-164378 PKA activation in glucagon signalling 0.032477 1.488
R-HSA-4839744 Signaling by APC mutants 0.156738 0.805
R-HSA-4839748 Signaling by AMER1 mutants 0.166948 0.777
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.187003 0.728
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.089718 1.047
R-HSA-429914 Deadenylation-dependent mRNA decay 0.049313 1.307
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.280292 0.552
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.161948 0.791
R-HSA-111471 Apoptotic factor-mediated response 0.244328 0.612
R-HSA-5689603 UCH proteinases 0.272508 0.565
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.125352 0.902
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.244328 0.612
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.262528 0.581
R-HSA-9843745 Adipogenesis 0.034911 1.457
R-HSA-9909396 Circadian clock 0.269507 0.569
R-HSA-212165 Epigenetic regulation of gene expression 0.060187 1.221
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.125352 0.902
R-HSA-8875555 MET activates RAP1 and RAC1 0.146402 0.834
R-HSA-174362 Transport and metabolism of PAPS 0.206576 0.685
R-HSA-5632684 Hedgehog 'on' state 0.250068 0.602
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.254554 0.594
R-HSA-3214841 PKMTs methylate histone lysines 0.116537 0.934
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.236628 0.626
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.254554 0.594
R-HSA-5610787 Hedgehog 'off' state 0.047753 1.321
R-HSA-177504 Retrograde neurotrophin signalling 0.196849 0.706
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.225681 0.647
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.244328 0.612
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.271464 0.566
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.308335 0.511
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.254554 0.594
R-HSA-201681 TCF dependent signaling in response to WNT 0.102098 0.991
R-HSA-933541 TRAF6 mediated IRF7 activation 0.100971 0.996
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.051112 1.291
R-HSA-1980143 Signaling by NOTCH1 0.083989 1.076
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.297631 0.526
R-HSA-5358351 Signaling by Hedgehog 0.122100 0.913
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.040537 1.392
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.100971 0.996
R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 0.235061 0.629
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.262528 0.581
R-HSA-193648 NRAGE signals death through JNK 0.183516 0.736
R-HSA-5693532 DNA Double-Strand Break Repair 0.345446 0.462
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.027503 1.561
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.183516 0.736
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.051112 1.291
R-HSA-2262752 Cellular responses to stress 0.284744 0.546
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.081690 1.088
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.025143 1.600
R-HSA-8948747 Regulation of PTEN localization 0.114634 0.941
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 0.114634 0.941
R-HSA-446199 Synthesis of dolichyl-phosphate 0.052309 1.281
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.166948 0.777
R-HSA-9839394 TGFBR3 expression 0.055421 1.256
R-HSA-877312 Regulation of IFNG signaling 0.177036 0.752
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.187003 0.728
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.187003 0.728
R-HSA-432047 Passive transport by Aquaporins 0.225681 0.647
R-HSA-8875878 MET promotes cell motility 0.104805 0.980
R-HSA-113510 E2F mediated regulation of DNA replication 0.253483 0.596
R-HSA-445095 Interaction between L1 and Ankyrins 0.331070 0.480
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.347191 0.459
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.047547 1.323
R-HSA-195721 Signaling by WNT 0.193271 0.714
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.177036 0.752
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.209897 0.678
R-HSA-8953897 Cellular responses to stimuli 0.178833 0.748
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.087559 1.058
R-HSA-5336415 Uptake and function of diphtheria toxin 0.114634 0.941
R-HSA-1483248 Synthesis of PIPs at the ER membrane 0.156738 0.805
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.206576 0.685
R-HSA-3371568 Attenuation phase 0.112590 0.949
R-HSA-9634597 GPER1 signaling 0.149247 0.826
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.289014 0.539
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.314553 0.502
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.322862 0.491
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.370651 0.431
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.070786 1.150
R-HSA-73887 Death Receptor Signaling 0.348753 0.457
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.052309 1.281
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.225681 0.647
R-HSA-8963693 Aspartate and asparagine metabolism 0.362926 0.440
R-HSA-9006931 Signaling by Nuclear Receptors 0.097973 1.009
R-HSA-936837 Ion transport by P-type ATPases 0.218777 0.660
R-HSA-8878171 Transcriptional regulation by RUNX1 0.081784 1.087
R-HSA-3323169 Defects in biotin (Btn) metabolism 0.135941 0.867
R-HSA-9627069 Regulation of the apoptosome activity 0.146402 0.834
R-HSA-6793080 rRNA modification in the mitochondrion 0.187003 0.728
R-HSA-180024 DARPP-32 events 0.068484 1.164
R-HSA-9833109 Evasion by RSV of host interferon responses 0.075358 1.123
R-HSA-163359 Glucagon signaling in metabolic regulation 0.086056 1.065
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.093426 1.030
R-HSA-9675151 Disorders of Developmental Biology 0.225681 0.647
R-HSA-209905 Catecholamine biosynthesis 0.235061 0.629
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.136764 0.864
R-HSA-5689901 Metalloprotease DUBs 0.322862 0.491
R-HSA-77387 Insulin receptor recycling 0.339180 0.470
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.276996 0.558
R-HSA-445717 Aquaporin-mediated transport 0.052942 1.276
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.294927 0.530
R-HSA-400685 Sema4D in semaphorin signaling 0.314553 0.502
R-HSA-3247509 Chromatin modifying enzymes 0.037071 1.431
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.214333 0.669
R-HSA-8848021 Signaling by PTK6 0.214333 0.669
R-HSA-9932444 ATP-dependent chromatin remodelers 0.314553 0.502
R-HSA-9932451 SWI/SNF chromatin remodelers 0.314553 0.502
R-HSA-9856872 Malate-aspartate shuttle 0.196849 0.706
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.206576 0.685
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.028694 1.542
R-HSA-1237112 Methionine salvage pathway 0.253483 0.596
R-HSA-525793 Myogenesis 0.322862 0.491
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.339180 0.470
R-HSA-5688426 Deubiquitination 0.052582 1.279
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.086929 1.061
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.086929 1.061
R-HSA-73884 Base Excision Repair 0.339404 0.469
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.071894 1.143
R-HSA-9031628 NGF-stimulated transcription 0.031673 1.499
R-HSA-74160 Gene expression (Transcription) 0.303304 0.518
R-HSA-156711 Polo-like kinase mediated events 0.244328 0.612
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.136764 0.864
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.365694 0.437
R-HSA-8941326 RUNX2 regulates bone development 0.097177 1.012
R-HSA-9937008 Mitochondrial mRNA modification 0.297631 0.526
R-HSA-3371571 HSF1-dependent transactivation 0.161948 0.791
R-HSA-70635 Urea cycle 0.322862 0.491
R-HSA-1169408 ISG15 antiviral mechanism 0.268019 0.572
R-HSA-5689880 Ub-specific processing proteases 0.207385 0.683
R-HSA-9707616 Heme signaling 0.054803 1.261
R-HSA-9819196 Zygotic genome activation (ZGA) 0.040537 1.392
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.098479 1.007
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.259042 0.587
R-HSA-430116 GP1b-IX-V activation signalling 0.135941 0.867
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.040537 1.392
R-HSA-9683610 Maturation of nucleoprotein 0.187003 0.728
R-HSA-8876725 Protein methylation 0.206576 0.685
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.253483 0.596
R-HSA-174403 Glutathione synthesis and recycling 0.280292 0.552
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.227690 0.643
R-HSA-6802957 Oncogenic MAPK signaling 0.105583 0.976
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.250068 0.602
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.343811 0.464
R-HSA-982772 Growth hormone receptor signaling 0.297631 0.526
R-HSA-9614085 FOXO-mediated transcription 0.046477 1.333
R-HSA-114452 Activation of BH3-only proteins 0.355106 0.450
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.123646 0.908
R-HSA-111458 Formation of apoptosome 0.146402 0.834
R-HSA-200425 Carnitine shuttle 0.297631 0.526
R-HSA-73614 Pyrimidine salvage 0.339180 0.470
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.308335 0.511
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.212422 0.673
R-HSA-446728 Cell junction organization 0.073672 1.133
R-HSA-418990 Adherens junctions interactions 0.166375 0.779
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.032477 1.488
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.206576 0.685
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.322862 0.491
R-HSA-421270 Cell-cell junction organization 0.236045 0.627
R-HSA-9006936 Signaling by TGFB family members 0.173207 0.761
R-HSA-111933 Calmodulin induced events 0.097177 1.012
R-HSA-9839373 Signaling by TGFBR3 0.140899 0.851
R-HSA-9007101 Rab regulation of trafficking 0.077266 1.112
R-HSA-111997 CaM pathway 0.097177 1.012
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.124533 0.905
R-HSA-6807004 Negative regulation of MET activity 0.262528 0.581
R-HSA-9012852 Signaling by NOTCH3 0.179168 0.747
R-HSA-1500931 Cell-Cell communication 0.118025 0.928
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.331070 0.480
R-HSA-6806834 Signaling by MET 0.093333 1.030
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.058597 1.232
R-HSA-111996 Ca-dependent events 0.124533 0.905
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.208269 0.681
R-HSA-166520 Signaling by NTRKs 0.145664 0.837
R-HSA-69205 G1/S-Specific Transcription 0.097177 1.012
R-HSA-9694631 Maturation of nucleoprotein 0.253483 0.596
R-HSA-1489509 DAG and IP3 signaling 0.136764 0.864
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.289014 0.539
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.187880 0.726
R-HSA-163685 Integration of energy metabolism 0.040287 1.395
R-HSA-3781865 Diseases of glycosylation 0.235491 0.628
R-HSA-9793380 Formation of paraxial mesoderm 0.205470 0.687
R-HSA-3371556 Cellular response to heat stress 0.227461 0.643
R-HSA-8983711 OAS antiviral response 0.177036 0.752
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.290449 0.537
R-HSA-112043 PLC beta mediated events 0.205470 0.687
R-HSA-1251985 Nuclear signaling by ERBB4 0.112590 0.949
R-HSA-9860931 Response of endothelial cells to shear stress 0.165917 0.780
R-HSA-8957322 Metabolism of steroids 0.128823 0.890
R-HSA-438064 Post NMDA receptor activation events 0.326133 0.487
R-HSA-9013694 Signaling by NOTCH4 0.263530 0.579
R-HSA-9855142 Cellular responses to mechanical stimuli 0.199173 0.701
R-HSA-112040 G-protein mediated events 0.232156 0.634
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.052309 1.281
R-HSA-8863678 Neurodegenerative Diseases 0.052309 1.281
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.358663 0.445
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.348753 0.457
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.061833 1.209
R-HSA-9730414 MITF-M-regulated melanocyte development 0.315808 0.501
R-HSA-186712 Regulation of beta-cell development 0.196651 0.706
R-HSA-1236394 Signaling by ERBB4 0.263530 0.579
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.245807 0.609
R-HSA-2028269 Signaling by Hippo 0.235061 0.629
R-HSA-9645723 Diseases of programmed cell death 0.330565 0.481
R-HSA-8986944 Transcriptional Regulation by MECP2 0.343811 0.464
R-HSA-9607240 FLT3 Signaling 0.116537 0.934
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.132658 0.877
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.245584 0.610
R-HSA-1855170 IPs transport between nucleus and cytosol 0.378283 0.422
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.378283 0.422
R-HSA-5083635 Defective B3GALTL causes PpS 0.378283 0.422
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.378283 0.422
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.378283 0.422
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.378283 0.422
R-HSA-1839124 FGFR1 mutant receptor activation 0.378283 0.422
R-HSA-176187 Activation of ATR in response to replication stress 0.378283 0.422
R-HSA-9733709 Cardiogenesis 0.378283 0.422
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 0.378283 0.422
R-HSA-5675482 Regulation of necroptotic cell death 0.378283 0.422
R-HSA-354192 Integrin signaling 0.378283 0.422
R-HSA-422356 Regulation of insulin secretion 0.383000 0.417
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.385823 0.414
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.385823 0.414
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.385823 0.414
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.385823 0.414
R-HSA-193704 p75 NTR receptor-mediated signalling 0.387296 0.412
R-HSA-597592 Post-translational protein modification 0.391819 0.407
R-HSA-180746 Nuclear import of Rev protein 0.393271 0.405
R-HSA-1980145 Signaling by NOTCH2 0.393271 0.405
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.393271 0.405
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.393271 0.405
R-HSA-9768919 NPAS4 regulates expression of target genes 0.393271 0.405
R-HSA-1483255 PI Metabolism 0.400103 0.398
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.400103 0.398
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.400630 0.397
R-HSA-381042 PERK regulates gene expression 0.400630 0.397
R-HSA-3296482 Defects in vitamin and cofactor metabolism 0.400630 0.397
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.400630 0.397
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.407901 0.389
R-HSA-74158 RNA Polymerase III Transcription 0.407901 0.389
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.407901 0.389
R-HSA-432720 Lysosome Vesicle Biogenesis 0.407901 0.389
R-HSA-8853659 RET signaling 0.407901 0.389
R-HSA-111885 Opioid Signalling 0.408571 0.389
R-HSA-9833110 RSV-host interactions 0.412784 0.384
R-HSA-4641257 Degradation of AXIN 0.415083 0.382
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 0.415083 0.382
R-HSA-1296072 Voltage gated Potassium channels 0.415083 0.382
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.415083 0.382
R-HSA-110331 Cleavage of the damaged purine 0.415083 0.382
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.415083 0.382
R-HSA-5696398 Nucleotide Excision Repair 0.416982 0.380
R-HSA-73927 Depurination 0.422179 0.375
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.422179 0.375
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.422179 0.375
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.422179 0.375
R-HSA-211000 Gene Silencing by RNA 0.425333 0.371
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.429189 0.367
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.429189 0.367
R-HSA-3781860 Diseases associated with N-glycosylation of proteins 0.429189 0.367
R-HSA-201556 Signaling by ALK 0.429189 0.367
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.429485 0.367
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.436114 0.360
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.436114 0.360
R-HSA-177243 Interactions of Rev with host cellular proteins 0.436114 0.360
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.436114 0.360
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.436114 0.360
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.436114 0.360
R-HSA-8868766 rRNA processing in the mitochondrion 0.436114 0.360
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.436114 0.360
R-HSA-2559583 Cellular Senescence 0.436752 0.360
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.442956 0.354
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.442956 0.354
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.449716 0.347
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.449716 0.347
R-HSA-5655302 Signaling by FGFR1 in disease 0.449716 0.347
R-HSA-9683701 Translation of Structural Proteins 0.449716 0.347
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.450005 0.347
R-HSA-69275 G2/M Transition 0.455766 0.341
R-HSA-110329 Cleavage of the damaged pyrimidine 0.456393 0.341
R-HSA-73928 Depyrimidination 0.456393 0.341
R-HSA-453274 Mitotic G2-G2/M phases 0.462045 0.335
R-HSA-73621 Pyrimidine catabolism 0.462990 0.334
R-HSA-5668914 Diseases of metabolism 0.464087 0.333
R-HSA-190828 Gap junction trafficking 0.469508 0.328
R-HSA-373760 L1CAM interactions 0.470104 0.328
R-HSA-1592230 Mitochondrial biogenesis 0.474072 0.324
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.475946 0.322
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.475946 0.322
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.475946 0.322
R-HSA-5693538 Homology Directed Repair 0.478021 0.321
R-HSA-8878166 Transcriptional regulation by RUNX2 0.481953 0.317
R-HSA-5357905 Regulation of TNFR1 signaling 0.482307 0.317
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.482307 0.317
R-HSA-68875 Mitotic Prophase 0.485866 0.313
R-HSA-437239 Recycling pathway of L1 0.488591 0.311
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.489761 0.310
R-HSA-73894 DNA Repair 0.492883 0.307
R-HSA-157858 Gap junction trafficking and regulation 0.500933 0.300
R-HSA-9766229 Degradation of CDH1 0.500933 0.300
R-HSA-69206 G1/S Transition 0.508958 0.293
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.512741 0.290
R-HSA-69481 G2/M Checkpoints 0.516505 0.287
R-HSA-114608 Platelet degranulation 0.516505 0.287
R-HSA-68949 Orc1 removal from chromatin 0.518892 0.285
R-HSA-72187 mRNA 3'-end processing 0.518892 0.285
R-HSA-112382 Formation of RNA Pol II elongation complex 0.518892 0.285
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.518892 0.285
R-HSA-5339562 Uptake and actions of bacterial toxins 0.518892 0.285
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.524734 0.280
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.524734 0.280
R-HSA-1221632 Meiotic synapsis 0.524734 0.280
R-HSA-8948751 Regulation of PTEN stability and activity 0.524734 0.280
R-HSA-1640170 Cell Cycle 0.530224 0.276
R-HSA-72649 Translation initiation complex formation 0.530505 0.275
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.530505 0.275
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.535033 0.272
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.536207 0.271
R-HSA-8856688 Golgi-to-ER retrograde transport 0.538681 0.269
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.541840 0.266
R-HSA-75893 TNF signaling 0.541840 0.266
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.541840 0.266
R-HSA-5578775 Ion homeostasis 0.541840 0.266
R-HSA-209776 Metabolism of amine-derived hormones 0.541840 0.266
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.541840 0.266
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.542308 0.266
R-HSA-2980766 Nuclear Envelope Breakdown 0.547405 0.262
R-HSA-9764561 Regulation of CDH1 Function 0.547405 0.262
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.552903 0.257
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.552903 0.257
R-HSA-180786 Extension of Telomeres 0.558334 0.253
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.558334 0.253
R-HSA-191859 snRNP Assembly 0.558334 0.253
R-HSA-194441 Metabolism of non-coding RNA 0.558334 0.253
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.560150 0.252
R-HSA-983189 Kinesins 0.563700 0.249
R-HSA-156590 Glutathione conjugation 0.563700 0.249
R-HSA-168325 Viral Messenger RNA Synthesis 0.569000 0.245
R-HSA-73856 RNA Polymerase II Transcription Termination 0.569000 0.245
R-HSA-450294 MAP kinase activation 0.569000 0.245
R-HSA-8956321 Nucleotide salvage 0.569000 0.245
R-HSA-6784531 tRNA processing in the nucleus 0.574237 0.241
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.574237 0.241
R-HSA-69278 Cell Cycle, Mitotic 0.574734 0.241
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.579410 0.237
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.579410 0.237
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.579410 0.237
R-HSA-6799198 Complex I biogenesis 0.579410 0.237
R-HSA-373755 Semaphorin interactions 0.579410 0.237
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.580901 0.236
R-HSA-8856828 Clathrin-mediated endocytosis 0.584290 0.233
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.588157 0.231
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.594334 0.226
R-HSA-8854518 AURKA Activation by TPX2 0.594558 0.226
R-HSA-1852241 Organelle biogenesis and maintenance 0.595373 0.225
R-HSA-5693606 DNA Double Strand Break Response 0.599486 0.222
R-HSA-196807 Nicotinate metabolism 0.599486 0.222
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.600929 0.221
R-HSA-9758941 Gastrulation 0.604196 0.219
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.604354 0.219
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.604354 0.219
R-HSA-5218859 Regulated Necrosis 0.604354 0.219
R-HSA-9856651 MITF-M-dependent gene expression 0.607444 0.216
R-HSA-162582 Signal Transduction 0.608822 0.216
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.610671 0.214
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.613914 0.212
R-HSA-448424 Interleukin-17 signaling 0.613914 0.212
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.613914 0.212
R-HSA-73857 RNA Polymerase II Transcription 0.614240 0.212
R-HSA-157118 Signaling by NOTCH 0.614670 0.211
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.618608 0.209
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.618608 0.209
R-HSA-5578749 Transcriptional regulation by small RNAs 0.623244 0.205
R-HSA-1989781 PPARA activates gene expression 0.623378 0.205
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.627825 0.202
R-HSA-69052 Switching of origins to a post-replicative state 0.627825 0.202
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.629611 0.201
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.632350 0.199
R-HSA-69473 G2/M DNA damage checkpoint 0.632350 0.199
R-HSA-1226099 Signaling by FGFR in disease 0.632350 0.199
R-HSA-380287 Centrosome maturation 0.636821 0.196
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.636821 0.196
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.636821 0.196
R-HSA-212436 Generic Transcription Pathway 0.643624 0.191
R-HSA-109581 Apoptosis 0.644845 0.191
R-HSA-9694635 Translation of Structural Proteins 0.645600 0.190
R-HSA-416482 G alpha (12/13) signalling events 0.649911 0.187
R-HSA-191273 Cholesterol biosynthesis 0.649911 0.187
R-HSA-9659379 Sensory processing of sound 0.654169 0.184
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes 0.654169 0.184
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.658375 0.182
R-HSA-5693607 Processing of DNA double-strand break ends 0.662531 0.179
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.666636 0.176
R-HSA-9707564 Cytoprotection by HMOX1 0.670692 0.173
R-HSA-418555 G alpha (s) signalling events 0.673827 0.171
R-HSA-5621481 C-type lectin receptors (CLRs) 0.673827 0.171
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.674698 0.171
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.676617 0.170
R-HSA-1500620 Meiosis 0.678656 0.168
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.679389 0.168
R-HSA-9664433 Leishmania parasite growth and survival 0.679389 0.168
R-HSA-9678108 SARS-CoV-1 Infection 0.684873 0.164
R-HSA-381038 XBP1(S) activates chaperone genes 0.686429 0.163
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.686429 0.163
R-HSA-1614635 Sulfur amino acid metabolism 0.686429 0.163
R-HSA-611105 Respiratory electron transport 0.692957 0.159
R-HSA-156902 Peptide chain elongation 0.694015 0.159
R-HSA-76002 Platelet activation, signaling and aggregation 0.696020 0.157
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.708643 0.150
R-HSA-199991 Membrane Trafficking 0.709117 0.149
R-HSA-156842 Eukaryotic Translation Elongation 0.712190 0.147
R-HSA-74752 Signaling by Insulin receptor 0.712190 0.147
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.712190 0.147
R-HSA-68867 Assembly of the pre-replicative complex 0.715695 0.145
R-HSA-983712 Ion channel transport 0.721149 0.142
R-HSA-5617833 Cilium Assembly 0.723601 0.141
R-HSA-168898 Toll-like Receptor Cascades 0.726035 0.139
R-HSA-913531 Interferon Signaling 0.726710 0.139
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.728452 0.138
R-HSA-5389840 Mitochondrial translation elongation 0.729291 0.137
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.729291 0.137
R-HSA-1296071 Potassium Channels 0.729291 0.137
R-HSA-68877 Mitotic Prometaphase 0.730850 0.136
R-HSA-157579 Telomere Maintenance 0.732588 0.135
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.732588 0.135
R-HSA-5368286 Mitochondrial translation initiation 0.735845 0.133
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.735845 0.133
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.735845 0.133
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.735845 0.133
R-HSA-70171 Glycolysis 0.742241 0.129
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.747139 0.127
R-HSA-389948 Co-inhibition by PD-1 0.747139 0.127
R-HSA-9842860 Regulation of endogenous retroelements 0.748483 0.126
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.748483 0.126
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.751547 0.124
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.754574 0.122
R-HSA-5357801 Programmed Cell Death 0.760425 0.119
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.760519 0.119
R-HSA-9692914 SARS-CoV-1-host interactions 0.763437 0.117
R-HSA-69239 Synthesis of DNA 0.766320 0.116
R-HSA-9700206 Signaling by ALK in cancer 0.766320 0.116
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.766320 0.116
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.769168 0.114
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.769168 0.114
R-HSA-5419276 Mitochondrial translation termination 0.771982 0.112
R-HSA-69002 DNA Replication Pre-Initiation 0.771982 0.112
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.771982 0.112
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.774761 0.111
R-HSA-166166 MyD88-independent TLR4 cascade 0.774761 0.111
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.775162 0.111
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.780219 0.108
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.780219 0.108
R-HSA-1483249 Inositol phosphate metabolism 0.780219 0.108
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.782899 0.106
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.785546 0.105
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.790744 0.102
R-HSA-8951664 Neddylation 0.792946 0.101
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.793296 0.101
R-HSA-909733 Interferon alpha/beta signaling 0.793296 0.101
R-HSA-72613 Eukaryotic Translation Initiation 0.795816 0.099
R-HSA-72737 Cap-dependent Translation Initiation 0.795816 0.099
R-HSA-70326 Glucose metabolism 0.798307 0.098
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.803197 0.095
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.803197 0.095
R-HSA-9705683 SARS-CoV-2-host interactions 0.805913 0.094
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.807705 0.093
R-HSA-73886 Chromosome Maintenance 0.807969 0.093
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.810312 0.091
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.810312 0.091
R-HSA-2132295 MHC class II antigen presentation 0.812626 0.090
R-HSA-72312 rRNA processing 0.812995 0.090
R-HSA-162909 Host Interactions of HIV factors 0.814912 0.089
R-HSA-9006925 Intracellular signaling by second messengers 0.818814 0.087
R-HSA-194138 Signaling by VEGF 0.819402 0.087
R-HSA-422475 Axon guidance 0.821574 0.085
R-HSA-8953854 Metabolism of RNA 0.822508 0.085
R-HSA-8956319 Nucleotide catabolism 0.828058 0.082
R-HSA-9694516 SARS-CoV-2 Infection 0.828696 0.082
R-HSA-1474165 Reproduction 0.832231 0.080
R-HSA-9679506 SARS-CoV Infections 0.832951 0.079
R-HSA-5576891 Cardiac conduction 0.834279 0.079
R-HSA-5173105 O-linked glycosylation 0.847936 0.072
R-HSA-196854 Metabolism of vitamins and cofactors 0.848333 0.071
R-HSA-5368287 Mitochondrial translation 0.849793 0.071
R-HSA-388841 Regulation of T cell activation by CD28 family 0.850852 0.070
R-HSA-6807070 PTEN Regulation 0.851628 0.070
R-HSA-69620 Cell Cycle Checkpoints 0.853671 0.069
R-HSA-162599 Late Phase of HIV Life Cycle 0.858747 0.066
R-HSA-9734767 Developmental Cell Lineages 0.860508 0.065
R-HSA-9675108 Nervous system development 0.860755 0.065
R-HSA-109582 Hemostasis 0.863198 0.064
R-HSA-9711123 Cellular response to chemical stress 0.867053 0.062
R-HSA-69242 S Phase 0.868793 0.061
R-HSA-68886 M Phase 0.870391 0.060
R-HSA-9679191 Potential therapeutics for SARS 0.871981 0.059
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.875092 0.058
R-HSA-69306 DNA Replication 0.876619 0.057
R-HSA-9609507 Protein localization 0.876619 0.057
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.879618 0.056
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.880475 0.055
R-HSA-5653656 Vesicle-mediated transport 0.881944 0.055
R-HSA-9610379 HCMV Late Events 0.882545 0.054
R-HSA-162587 HIV Life Cycle 0.882545 0.054
R-HSA-9824443 Parasitic Infection Pathways 0.882778 0.054
R-HSA-9658195 Leishmania infection 0.882778 0.054
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.883914 0.054
R-HSA-9711097 Cellular response to starvation 0.883981 0.054
R-HSA-877300 Interferon gamma signaling 0.885400 0.053
R-HSA-1266738 Developmental Biology 0.885600 0.053
R-HSA-5633007 Regulation of TP53 Activity 0.886802 0.052
R-HSA-392499 Metabolism of proteins 0.889852 0.051
R-HSA-2408522 Selenoamino acid metabolism 0.892240 0.050
R-HSA-5619102 SLC transporter disorders 0.896148 0.048
R-HSA-1483257 Phospholipid metabolism 0.897785 0.047
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.901140 0.045
R-HSA-72306 tRNA processing 0.901140 0.045
R-HSA-446203 Asparagine N-linked glycosylation 0.907817 0.042
R-HSA-168255 Influenza Infection 0.911515 0.040
R-HSA-72766 Translation 0.913264 0.039
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.920807 0.036
R-HSA-1280215 Cytokine Signaling in Immune system 0.921684 0.035
R-HSA-112315 Transmission across Chemical Synapses 0.922599 0.035
R-HSA-1630316 Glycosaminoglycan metabolism 0.925542 0.034
R-HSA-72163 mRNA Splicing - Major Pathway 0.926455 0.033
R-HSA-9609690 HCMV Early Events 0.928247 0.032
R-HSA-376176 Signaling by ROBO receptors 0.934185 0.030
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.935441 0.029
R-HSA-72172 mRNA Splicing 0.935790 0.029
R-HSA-3700989 Transcriptional Regulation by TP53 0.936940 0.028
R-HSA-112316 Neuronal System 0.938618 0.028
R-HSA-397014 Muscle contraction 0.941829 0.026
R-HSA-68882 Mitotic Anaphase 0.944633 0.025
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.945312 0.024
R-HSA-162906 HIV Infection 0.951669 0.022
R-HSA-71291 Metabolism of amino acids and derivatives 0.953903 0.020
R-HSA-15869 Metabolism of nucleotides 0.956759 0.019
R-HSA-156580 Phase II - Conjugation of compounds 0.958335 0.018
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.958457 0.018
R-HSA-5619115 Disorders of transmembrane transporters 0.962261 0.017
R-HSA-9609646 HCMV Infection 0.963637 0.016
R-HSA-418594 G alpha (i) signalling events 0.967653 0.014
R-HSA-416476 G alpha (q) signalling events 0.969426 0.013
R-HSA-1280218 Adaptive Immune System 0.977388 0.010
R-HSA-1257604 PIP3 activates AKT signaling 0.979185 0.009
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.980540 0.009
R-HSA-449147 Signaling by Interleukins 0.986071 0.006
R-HSA-388396 GPCR downstream signalling 0.988443 0.005
R-HSA-556833 Metabolism of lipids 0.990296 0.004
R-HSA-9824439 Bacterial Infection Pathways 0.993702 0.003
R-HSA-382551 Transport of small molecules 0.994510 0.002
R-HSA-372790 Signaling by GPCR 0.994717 0.002
R-HSA-8978868 Fatty acid metabolism 0.994907 0.002
R-HSA-1643685 Disease 0.995402 0.002
R-HSA-6798695 Neutrophil degranulation 0.997277 0.001
R-HSA-9824446 Viral Infection Pathways 0.998604 0.001
R-HSA-211859 Biological oxidations 0.998812 0.001
R-HSA-5663205 Infectious disease 0.999745 0.000
R-HSA-168249 Innate Immune System 0.999813 0.000
R-HSA-168256 Immune System 0.999825 0.000
R-HSA-1430728 Metabolism 0.999988 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK19CDK19 0.872 0.830 1 0.848
KISKIS 0.872 0.784 1 0.799
HIPK2HIPK2 0.871 0.796 1 0.851
CDK8CDK8 0.869 0.834 1 0.817
P38GP38G 0.869 0.881 1 0.890
CDK18CDK18 0.867 0.839 1 0.861
CDK17CDK17 0.867 0.860 1 0.884
JNK2JNK2 0.866 0.883 1 0.859
P38DP38D 0.863 0.861 1 0.901
CDK13CDK13 0.863 0.842 1 0.843
DYRK2DYRK2 0.863 0.786 1 0.772
CDK7CDK7 0.862 0.820 1 0.822
CDK3CDK3 0.861 0.750 1 0.878
CDK12CDK12 0.860 0.841 1 0.862
CDK1CDK1 0.860 0.818 1 0.839
ERK1ERK1 0.860 0.833 1 0.841
CDK5CDK5 0.859 0.808 1 0.796
JNK3JNK3 0.858 0.872 1 0.836
CDK9CDK9 0.858 0.835 1 0.836
CDK16CDK16 0.858 0.818 1 0.874
DYRK4DYRK4 0.857 0.792 1 0.857
P38BP38B 0.856 0.834 1 0.824
DYRK1BDYRK1B 0.854 0.770 1 0.824
CDK10CDK10 0.852 0.782 1 0.844
HIPK4HIPK4 0.851 0.530 1 0.574
HIPK1HIPK1 0.851 0.728 1 0.755
CLK3CLK3 0.851 0.525 1 0.533
CDK14CDK14 0.849 0.814 1 0.829
ERK2ERK2 0.848 0.835 1 0.801
P38AP38A 0.847 0.805 1 0.765
NLKNLK 0.845 0.757 1 0.575
CDK4CDK4 0.844 0.819 1 0.871
DYRK1ADYRK1A 0.843 0.642 1 0.738
HIPK3HIPK3 0.843 0.709 1 0.732
CDK6CDK6 0.841 0.791 1 0.847
SRPK1SRPK1 0.840 0.376 -3 0.768
DYRK3DYRK3 0.838 0.599 1 0.722
JNK1JNK1 0.836 0.778 1 0.857
CLK1CLK1 0.836 0.458 -3 0.753
SRPK2SRPK2 0.834 0.321 -3 0.694
CDK2CDK2 0.834 0.632 1 0.724
CLK2CLK2 0.832 0.451 -3 0.750
CLK4CLK4 0.831 0.430 -3 0.772
ERK5ERK5 0.831 0.406 1 0.477
MTORMTOR 0.823 0.223 1 0.367
ICKICK 0.822 0.376 -3 0.859
SRPK3SRPK3 0.820 0.282 -3 0.737
CDKL5CDKL5 0.818 0.176 -3 0.823
MAKMAK 0.817 0.503 -2 0.751
CDKL1CDKL1 0.816 0.162 -3 0.825
COTCOT 0.814 -0.091 2 0.857
PRP4PRP4 0.814 0.492 -3 0.806
MOKMOK 0.811 0.481 1 0.646
CDC7CDC7 0.811 -0.087 1 0.194
TBK1TBK1 0.808 -0.140 1 0.178
GCN2GCN2 0.808 -0.141 2 0.787
NDR2NDR2 0.807 -0.003 -3 0.844
PRKD1PRKD1 0.806 0.005 -3 0.857
PRPKPRPK 0.806 -0.103 -1 0.845
NEK6NEK6 0.806 -0.045 -2 0.867
TGFBR2TGFBR2 0.805 -0.026 -2 0.853
MOSMOS 0.805 -0.043 1 0.242
PIM3PIM3 0.805 -0.019 -3 0.839
IKKEIKKE 0.804 -0.152 1 0.179
ATRATR 0.804 -0.047 1 0.251
PRKD2PRKD2 0.804 0.028 -3 0.788
CAMK1BCAMK1B 0.804 -0.011 -3 0.873
MST4MST4 0.804 -0.018 2 0.844
BMPR2BMPR2 0.803 -0.102 -2 0.891
RSK2RSK2 0.803 0.026 -3 0.792
PKN3PKN3 0.803 -0.032 -3 0.842
NUAK2NUAK2 0.802 0.024 -3 0.835
PDHK4PDHK4 0.802 -0.158 1 0.261
ULK2ULK2 0.802 -0.171 2 0.786
NDR1NDR1 0.801 -0.024 -3 0.844
WNK1WNK1 0.801 -0.065 -2 0.878
RSK3RSK3 0.801 0.018 -3 0.787
DSTYKDSTYK 0.800 -0.134 2 0.852
RAF1RAF1 0.800 -0.193 1 0.196
ERK7ERK7 0.800 0.265 2 0.523
PDHK1PDHK1 0.800 -0.149 1 0.242
CAMLCKCAMLCK 0.800 0.025 -2 0.876
P90RSKP90RSK 0.800 0.019 -3 0.798
PKCDPKCD 0.799 -0.009 2 0.771
AURCAURC 0.799 0.053 -2 0.719
NEK7NEK7 0.799 -0.141 -3 0.857
NIKNIK 0.798 -0.048 -3 0.888
MARK4MARK4 0.798 -0.036 4 0.835
IKKBIKKB 0.797 -0.185 -2 0.726
AMPKA1AMPKA1 0.796 -0.042 -3 0.857
PIM1PIM1 0.796 0.033 -3 0.783
CHAK2CHAK2 0.796 -0.061 -1 0.851
P70S6KBP70S6KB 0.796 0.025 -3 0.810
PKN2PKN2 0.795 -0.054 -3 0.843
MAPKAPK3MAPKAPK3 0.795 -0.041 -3 0.800
DAPK2DAPK2 0.795 -0.012 -3 0.883
AMPKA2AMPKA2 0.795 -0.016 -3 0.826
PKACGPKACG 0.795 0.004 -2 0.774
WNK3WNK3 0.794 -0.159 1 0.203
IRE1IRE1 0.794 -0.077 1 0.201
NIM1NIM1 0.794 -0.046 3 0.821
SKMLCKSKMLCK 0.793 -0.050 -2 0.880
ULK1ULK1 0.793 -0.157 -3 0.837
LATS2LATS2 0.793 -0.040 -5 0.767
TSSK1TSSK1 0.793 -0.033 -3 0.877
CAMK2GCAMK2G 0.792 -0.122 2 0.771
RIPK3RIPK3 0.792 -0.156 3 0.759
PRKD3PRKD3 0.791 0.009 -3 0.759
MNK2MNK2 0.791 -0.008 -2 0.827
IRE2IRE2 0.791 -0.058 2 0.752
MAPKAPK2MAPKAPK2 0.791 -0.023 -3 0.749
PAK6PAK6 0.791 0.020 -2 0.751
MLK1MLK1 0.790 -0.168 2 0.798
NEK9NEK9 0.790 -0.165 2 0.835
PAK3PAK3 0.790 -0.033 -2 0.814
BCKDKBCKDK 0.790 -0.151 -1 0.808
NUAK1NUAK1 0.789 -0.024 -3 0.797
ALK4ALK4 0.789 -0.018 -2 0.866
HUNKHUNK 0.789 -0.164 2 0.790
PHKG1PHKG1 0.789 -0.056 -3 0.833
AURBAURB 0.789 0.028 -2 0.713
MLK2MLK2 0.788 -0.127 2 0.818
MELKMELK 0.788 -0.054 -3 0.822
DNAPKDNAPK 0.788 -0.037 1 0.250
PINK1PINK1 0.788 0.170 1 0.408
PAK1PAK1 0.788 -0.022 -2 0.817
ATMATM 0.788 -0.073 1 0.218
LATS1LATS1 0.788 0.008 -3 0.866
GRK5GRK5 0.787 -0.170 -3 0.850
BMPR1BBMPR1B 0.787 -0.028 1 0.149
TSSK2TSSK2 0.787 -0.086 -5 0.834
CAMK2DCAMK2D 0.787 -0.109 -3 0.865
QSKQSK 0.787 -0.012 4 0.816
PKRPKR 0.787 -0.064 1 0.222
IKKAIKKA 0.786 -0.112 -2 0.710
TGFBR1TGFBR1 0.786 -0.023 -2 0.843
PKCBPKCB 0.786 -0.034 2 0.723
VRK2VRK2 0.786 0.068 1 0.297
AKT2AKT2 0.786 0.053 -3 0.696
PKACBPKACB 0.786 0.044 -2 0.729
PKCAPKCA 0.786 -0.021 2 0.712
SGK3SGK3 0.785 0.021 -3 0.777
PKG2PKG2 0.785 0.020 -2 0.726
ANKRD3ANKRD3 0.785 -0.168 1 0.214
NEK2NEK2 0.785 -0.114 2 0.812
MLK3MLK3 0.785 -0.083 2 0.719
MSK2MSK2 0.785 -0.019 -3 0.764
RIPK1RIPK1 0.784 -0.190 1 0.190
SMG1SMG1 0.784 -0.056 1 0.241
MNK1MNK1 0.784 -0.010 -2 0.834
MASTLMASTL 0.784 -0.200 -2 0.797
MPSK1MPSK1 0.784 0.049 1 0.262
RSK4RSK4 0.784 0.023 -3 0.751
PKCZPKCZ 0.783 -0.045 2 0.773
CAMK4CAMK4 0.783 -0.101 -3 0.822
GSK3AGSK3A 0.783 0.195 4 0.454
QIKQIK 0.783 -0.081 -3 0.844
SIKSIK 0.783 -0.024 -3 0.766
GRK1GRK1 0.782 -0.073 -2 0.767
GRK7GRK7 0.782 -0.009 1 0.204
PIM2PIM2 0.782 0.045 -3 0.762
PKCGPKCG 0.782 -0.049 2 0.711
PKCHPKCH 0.781 -0.053 2 0.707
PAK2PAK2 0.780 -0.041 -2 0.801
YSK4YSK4 0.780 -0.155 1 0.178
DLKDLK 0.780 -0.232 1 0.196
BRSK2BRSK2 0.780 -0.077 -3 0.830
PLK1PLK1 0.780 -0.125 -2 0.828
GRK6GRK6 0.780 -0.159 1 0.180
HRIHRI 0.780 -0.104 -2 0.877
TLK2TLK2 0.780 -0.097 1 0.199
CHAK1CHAK1 0.779 -0.137 2 0.782
AKT1AKT1 0.779 0.039 -3 0.715
MSK1MSK1 0.779 0.001 -3 0.767
ACVR2AACVR2A 0.779 -0.064 -2 0.842
PRKXPRKX 0.779 0.051 -3 0.668
PERKPERK 0.779 -0.095 -2 0.866
TTBK2TTBK2 0.778 -0.206 2 0.695
MARK3MARK3 0.778 -0.025 4 0.786
ACVR2BACVR2B 0.777 -0.070 -2 0.845
MARK2MARK2 0.777 -0.034 4 0.750
MEK1MEK1 0.777 -0.143 2 0.827
BRSK1BRSK1 0.777 -0.059 -3 0.800
DCAMKL1DCAMKL1 0.776 -0.036 -3 0.785
AURAAURA 0.776 0.008 -2 0.689
CHK1CHK1 0.776 -0.072 -3 0.842
MYLK4MYLK4 0.776 -0.018 -2 0.811
ALK2ALK2 0.775 -0.056 -2 0.845
PKCTPKCT 0.775 -0.039 2 0.722
WNK4WNK4 0.775 -0.102 -2 0.863
GRK4GRK4 0.775 -0.183 -2 0.814
CAMK2BCAMK2B 0.774 -0.085 2 0.732
P70S6KP70S6K 0.774 0.011 -3 0.733
PHKG2PHKG2 0.774 -0.070 -3 0.800
PLK4PLK4 0.773 -0.121 2 0.628
CAMK2ACAMK2A 0.773 -0.054 2 0.745
MAPKAPK5MAPKAPK5 0.773 -0.083 -3 0.756
CAMK1GCAMK1G 0.773 -0.047 -3 0.774
IRAK4IRAK4 0.773 -0.119 1 0.185
MLK4MLK4 0.773 -0.135 2 0.708
SNRKSNRK 0.772 -0.140 2 0.692
TLK1TLK1 0.772 -0.106 -2 0.845
PKACAPKACA 0.771 0.030 -2 0.688
FAM20CFAM20C 0.771 -0.059 2 0.537
PAK5PAK5 0.771 -0.010 -2 0.686
BMPR1ABMPR1A 0.771 -0.040 1 0.138
PKCIPKCI 0.771 -0.021 2 0.735
MARK1MARK1 0.770 -0.064 4 0.798
MEKK1MEKK1 0.770 -0.159 1 0.209
SSTKSSTK 0.770 -0.041 4 0.802
MEK5MEK5 0.770 -0.160 2 0.821
MST3MST3 0.770 -0.066 2 0.823
MEKK2MEKK2 0.769 -0.122 2 0.803
TAO3TAO3 0.769 -0.051 1 0.224
NEK5NEK5 0.769 -0.141 1 0.199
ZAKZAK 0.769 -0.162 1 0.181
GSK3BGSK3B 0.769 0.045 4 0.446
SMMLCKSMMLCK 0.768 -0.016 -3 0.836
DCAMKL2DCAMKL2 0.768 -0.058 -3 0.811
PLK3PLK3 0.768 -0.140 2 0.734
DRAK1DRAK1 0.766 -0.162 1 0.150
BUB1BUB1 0.766 0.039 -5 0.766
PAK4PAK4 0.765 -0.006 -2 0.696
BRAFBRAF 0.765 -0.150 -4 0.834
AKT3AKT3 0.765 0.041 -3 0.639
PKCEPKCE 0.765 0.001 2 0.697
PKN1PKN1 0.765 -0.027 -3 0.747
SGK1SGK1 0.765 0.062 -3 0.623
LKB1LKB1 0.764 -0.047 -3 0.861
MEKK3MEKK3 0.764 -0.194 1 0.197
GAKGAK 0.763 -0.037 1 0.244
HGKHGK 0.763 -0.055 3 0.917
TAO2TAO2 0.763 -0.063 2 0.832
TNIKTNIK 0.762 -0.033 3 0.917
PDK1PDK1 0.762 -0.074 1 0.234
MRCKAMRCKA 0.761 0.025 -3 0.766
GRK2GRK2 0.761 -0.117 -2 0.696
SBKSBK 0.761 0.117 -3 0.586
LOKLOK 0.761 -0.053 -2 0.772
NEK8NEK8 0.760 -0.156 2 0.812
NEK11NEK11 0.760 -0.149 1 0.218
PBKPBK 0.760 -0.013 1 0.228
MRCKBMRCKB 0.760 0.027 -3 0.747
CAMK1DCAMK1D 0.760 -0.034 -3 0.696
MEKK6MEKK6 0.759 -0.100 1 0.201
NEK4NEK4 0.759 -0.145 1 0.192
GCKGCK 0.759 -0.080 1 0.207
MINKMINK 0.758 -0.104 1 0.187
MAP3K15MAP3K15 0.757 -0.111 1 0.196
PASKPASK 0.757 -0.079 -3 0.853
KHS1KHS1 0.757 -0.039 1 0.209
DAPK3DAPK3 0.757 -0.018 -3 0.800
ROCK2ROCK2 0.756 0.017 -3 0.794
CAMKK2CAMKK2 0.756 -0.136 -2 0.745
TTBK1TTBK1 0.756 -0.174 2 0.610
LRRK2LRRK2 0.756 -0.034 2 0.834
CAMKK1CAMKK1 0.756 -0.193 -2 0.742
HPK1HPK1 0.756 -0.074 1 0.211
MST2MST2 0.755 -0.132 1 0.192
CHK2CHK2 0.755 -0.014 -3 0.647
NEK1NEK1 0.755 -0.132 1 0.183
KHS2KHS2 0.755 -0.018 1 0.220
HASPINHASPIN 0.754 0.003 -1 0.662
EEF2KEEF2K 0.754 -0.087 3 0.868
PKG1PKG1 0.753 0.001 -2 0.658
CRIKCRIK 0.753 0.061 -3 0.721
IRAK1IRAK1 0.752 -0.227 -1 0.759
BIKEBIKE 0.752 -0.006 1 0.232
SLKSLK 0.752 -0.067 -2 0.707
CAMK1ACAMK1A 0.752 -0.017 -3 0.663
CK1ECK1E 0.751 -0.069 -3 0.480
NEK3NEK3 0.751 -0.093 1 0.209
YSK1YSK1 0.751 -0.101 2 0.809
VRK1VRK1 0.751 -0.153 2 0.838
CK2A2CK2A2 0.749 -0.075 1 0.131
DMPK1DMPK1 0.749 0.045 -3 0.758
AAK1AAK1 0.749 0.028 1 0.234
MST1MST1 0.749 -0.134 1 0.186
DAPK1DAPK1 0.749 -0.026 -3 0.782
TAK1TAK1 0.748 -0.189 1 0.183
ROCK1ROCK1 0.747 0.016 -3 0.763
CK1G1CK1G1 0.746 -0.098 -3 0.474
MEK2MEK2 0.746 -0.177 2 0.816
RIPK2RIPK2 0.745 -0.206 1 0.168
CK1DCK1D 0.745 -0.042 -3 0.427
PDHK3_TYRPDHK3_TYR 0.745 0.103 4 0.855
LIMK2_TYRLIMK2_TYR 0.743 0.134 -3 0.915
GRK3GRK3 0.742 -0.126 -2 0.653
STK33STK33 0.740 -0.152 2 0.590
MYO3BMYO3B 0.740 -0.065 2 0.821
CK2A1CK2A1 0.739 -0.087 1 0.122
OSR1OSR1 0.739 -0.079 2 0.801
TESK1_TYRTESK1_TYR 0.739 0.026 3 0.927
CK1A2CK1A2 0.739 -0.068 -3 0.424
PKMYT1_TYRPKMYT1_TYR 0.739 0.118 3 0.889
TTKTTK 0.738 -0.070 -2 0.855
TAO1TAO1 0.738 -0.085 1 0.199
MYO3AMYO3A 0.736 -0.084 1 0.215
PDHK4_TYRPDHK4_TYR 0.735 0.019 2 0.861
PLK2PLK2 0.734 -0.115 -3 0.773
ASK1ASK1 0.734 -0.141 1 0.193
MAP2K4_TYRMAP2K4_TYR 0.733 -0.020 -1 0.867
MAP2K7_TYRMAP2K7_TYR 0.732 -0.091 2 0.843
RETRET 0.731 -0.110 1 0.220
MAP2K6_TYRMAP2K6_TYR 0.731 -0.019 -1 0.863
PINK1_TYRPINK1_TYR 0.730 -0.121 1 0.244
LIMK1_TYRLIMK1_TYR 0.730 0.003 2 0.845
NEK10_TYRNEK10_TYR 0.729 -0.066 1 0.202
BMPR2_TYRBMPR2_TYR 0.728 -0.025 -1 0.841
MST1RMST1R 0.727 -0.092 3 0.853
PDHK1_TYRPDHK1_TYR 0.726 -0.094 -1 0.877
JAK2JAK2 0.726 -0.117 1 0.227
TYK2TYK2 0.726 -0.184 1 0.209
ALPHAK3ALPHAK3 0.725 -0.117 -1 0.753
ROS1ROS1 0.723 -0.125 3 0.824
CSF1RCSF1R 0.723 -0.101 3 0.831
TYRO3TYRO3 0.722 -0.144 3 0.856
TNNI3K_TYRTNNI3K_TYR 0.721 -0.039 1 0.233
STLK3STLK3 0.721 -0.173 1 0.171
ABL2ABL2 0.720 -0.094 -1 0.827
JAK3JAK3 0.720 -0.121 1 0.204
EPHA6EPHA6 0.720 -0.114 -1 0.843
TNK1TNK1 0.720 -0.063 3 0.835
JAK1JAK1 0.720 -0.096 1 0.199
DDR1DDR1 0.718 -0.135 4 0.784
ABL1ABL1 0.718 -0.095 -1 0.826
YES1YES1 0.717 -0.103 -1 0.859
EPHB4EPHB4 0.717 -0.145 -1 0.830
TXKTXK 0.716 -0.092 1 0.149
FGFR1FGFR1 0.716 -0.045 3 0.797
FGFR2FGFR2 0.715 -0.062 3 0.816
TEKTEK 0.715 -0.017 3 0.779
LCKLCK 0.713 -0.099 -1 0.833
PDGFRBPDGFRB 0.713 -0.183 3 0.846
FLT3FLT3 0.712 -0.158 3 0.846
FGRFGR 0.712 -0.180 1 0.172
ITKITK 0.712 -0.135 -1 0.809
TNK2TNK2 0.711 -0.136 3 0.781
INSRRINSRR 0.711 -0.153 3 0.788
KDRKDR 0.711 -0.104 3 0.777
HCKHCK 0.711 -0.153 -1 0.835
BLKBLK 0.710 -0.093 -1 0.837
FERFER 0.709 -0.205 1 0.180
KITKIT 0.709 -0.148 3 0.828
YANK3YANK3 0.709 -0.096 2 0.369
PDGFRAPDGFRA 0.708 -0.196 3 0.846
EPHB1EPHB1 0.707 -0.189 1 0.159
AXLAXL 0.706 -0.175 3 0.811
EPHA4EPHA4 0.705 -0.128 2 0.724
WEE1_TYRWEE1_TYR 0.705 -0.094 -1 0.739
DDR2DDR2 0.705 -0.057 3 0.754
SRMSSRMS 0.705 -0.200 1 0.154
TECTEC 0.705 -0.134 -1 0.762
EPHB3EPHB3 0.704 -0.187 -1 0.819
MERTKMERTK 0.703 -0.166 3 0.811
EPHB2EPHB2 0.703 -0.171 -1 0.813
METMET 0.702 -0.139 3 0.828
BTKBTK 0.702 -0.202 -1 0.792
FGFR3FGFR3 0.702 -0.088 3 0.784
BMXBMX 0.701 -0.134 -1 0.717
ALKALK 0.701 -0.170 3 0.758
FRKFRK 0.699 -0.153 -1 0.850
CK1ACK1A 0.699 -0.093 -3 0.327
PTK6PTK6 0.698 -0.204 -1 0.746
FLT1FLT1 0.697 -0.158 -1 0.818
FYNFYN 0.697 -0.116 -1 0.796
LTKLTK 0.697 -0.183 3 0.766
FLT4FLT4 0.697 -0.165 3 0.764
ERBB2ERBB2 0.696 -0.186 1 0.178
EPHA1EPHA1 0.696 -0.174 3 0.802
NTRK2NTRK2 0.696 -0.215 3 0.790
PTK2BPTK2B 0.696 -0.105 -1 0.798
INSRINSR 0.695 -0.176 3 0.770
EPHA7EPHA7 0.694 -0.171 2 0.732
NTRK1NTRK1 0.694 -0.240 -1 0.811
MUSKMUSK 0.693 -0.132 1 0.136
EGFREGFR 0.693 -0.128 1 0.142
LYNLYN 0.691 -0.164 3 0.747
EPHA3EPHA3 0.690 -0.184 2 0.706
NTRK3NTRK3 0.689 -0.190 -1 0.758
SRCSRC 0.689 -0.143 -1 0.808
MATKMATK 0.688 -0.134 -1 0.742
FGFR4FGFR4 0.685 -0.140 -1 0.766
EPHA5EPHA5 0.685 -0.181 2 0.709
EPHA8EPHA8 0.684 -0.164 -1 0.789
CSKCSK 0.683 -0.190 2 0.743
CK1G3CK1G3 0.681 -0.091 -3 0.274
SYKSYK 0.678 -0.123 -1 0.738
PTK2PTK2 0.677 -0.107 -1 0.751
IGF1RIGF1R 0.677 -0.173 3 0.709
ERBB4ERBB4 0.675 -0.128 1 0.142
EPHA2EPHA2 0.675 -0.170 -1 0.756
YANK2YANK2 0.671 -0.123 2 0.378
ZAP70ZAP70 0.667 -0.088 -1 0.653
FESFES 0.660 -0.180 -1 0.699
CK1G2CK1G2 0.655 -0.103 -3 0.378