Motif 63 (n=174)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A4UGR9 | XIRP2 | S2996 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
A6NC98 | CCDC88B | S514 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
A6ND36 | FAM83G | S666 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
A6NHR9 | SMCHD1 | S1974 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
A6NIX2 | WTIP | S29 | ochoa | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
A7KAX9 | ARHGAP32 | S871 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
E7EW31 | PROB1 | S470 | ochoa | Proline-rich basic protein 1 | None |
O00592 | PODXL | S122 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
O14524 | NEMP1 | S368 | ochoa | Nuclear envelope integral membrane protein 1 | Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (By similarity). Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity). {ECO:0000250|UniProtKB:Q6ZQE4, ECO:0000269|PubMed:32923640}. |
O14686 | KMT2D | S2640 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14976 | GAK | S456 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
O14978 | ZNF263 | S166 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
O15085 | ARHGEF11 | S255 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
O15164 | TRIM24 | S811 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
O15169 | AXIN1 | S486 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
O15231 | ZNF185 | S307 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
O43299 | AP5Z1 | S732 | ochoa | AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}. |
O43521 | BCL2L11 | S104 | psp | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}. |
O43526 | KCNQ2 | S476 | ochoa|psp | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
O43680 | TCF21 | S67 | ochoa | Transcription factor 21 (TCF-21) (Capsulin) (Class A basic helix-loop-helix protein 23) (bHLHa23) (Epicardin) (Podocyte-expressed 1) (Pod-1) | Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. |
O60292 | SIPA1L3 | S1559 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O75161 | NPHP4 | S142 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
O75362 | ZNF217 | S407 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
O75369 | FLNB | S341 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75467 | ZNF324 | S164 | ochoa | Zinc finger protein 324A (Zinc finger protein ZF5128) | May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. {ECO:0000305|PubMed:11779640}. |
O75691 | UTP20 | S843 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
O94988 | FAM13A | S856 | ochoa | Protein FAM13A | None |
O95340 | PAPSS2 | S92 | ochoa | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708). {ECO:0000269|PubMed:11773860, ECO:0000269|PubMed:19474428, ECO:0000269|PubMed:23824674, ECO:0000269|PubMed:25594860, ECO:0000269|PubMed:9771708}. |
O96028 | NSD2 | S437 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
P05023 | ATP1A1 | S694 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
P06401 | PGR | S162 | ochoa|psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
P07101 | TH | S502 | ochoa | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
P08151 | GLI1 | S968 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
P09543 | CNP | S318 | ochoa | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) | Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}. |
P0C7T5 | ATXN1L | S361 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
P10644 | PRKAR1A | S83 | ochoa|psp | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}. |
P11441 | UBL4A | S90 | ochoa | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}. |
P11940 | PABPC1 | S434 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
P13639 | EEF2 | S595 | ochoa|psp | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
P13994 | YJU2B | S306 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
P17861 | XBP1 | S68 | ochoa|psp | X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] | Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}. |
P18031 | PTPN1 | S50 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
P18887 | XRCC1 | S199 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
P19971 | TYMP | S364 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
P21333 | FLNA | S368 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P31269 | HOXA9 | S161 | ochoa | Homeobox protein Hox-A9 (Homeobox protein Hox-1G) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}. |
P31321 | PRKAR1B | S83 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
P37275 | ZEB1 | S704 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
P42356 | PI4KA | S429 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
P42568 | MLLT3 | S483 | ochoa | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}. |
P48552 | NRIP1 | S218 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
P48637 | GSS | S137 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
P49715 | CEBPA | S21 | ochoa|psp | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}. |
P50570 | DNM2 | S764 | ochoa|psp | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P50851 | LRBA | S1498 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
P51114 | FXR1 | S496 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
P51610 | HCFC1 | S757 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
P53567 | CEBPG | S56 | ochoa | CCAAT/enhancer-binding protein gamma (C/EBP gamma) | Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}. |
P53602 | MVD | S222 | ochoa | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}. |
P53814 | SMTN | S514 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
P54253 | ATXN1 | S88 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
P55064 | AQP5 | S183 | psp | Aquaporin-5 (AQP-5) | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:18768791, PubMed:8621489). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). {ECO:0000250|UniProtKB:Q9WTY4, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:8621489}. |
P56524 | HDAC4 | S611 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
P98194 | ATP2C1 | S621 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
Q05519 | SRSF11 | S70 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
Q09472 | EP300 | S1726 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
Q12770 | SCAP | S907 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
Q12789 | GTF3C1 | S1856 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
Q13017 | ARHGAP5 | S765 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
Q13085 | ACACA | S488 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
Q13415 | ORC1 | S199 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
Q14135 | VGLL4 | S149 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
Q14197 | MRPL58 | Y49 | ochoa | Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29) | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294). {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:33878294}. |
Q14558 | PRPSAP1 | S177 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
Q14956 | GPNMB | S531 | ochoa | Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) | Could be a melanogenic enzyme. {ECO:0000250}. |
Q14980 | NUMA1 | S77 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q15036 | SNX17 | S434 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
Q155Q3 | DIXDC1 | S74 | ochoa | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}. |
Q15717 | ELAVL1 | S221 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
Q15797 | SMAD1 | S151 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
Q27J81 | INF2 | S372 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
Q2KJY2 | KIF26B | S1613 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
Q2LD37 | BLTP1 | S4308 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q2M2Z5 | KIZ | S179 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
Q3B820 | FAM161A | S396 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
Q3KR37 | GRAMD1B | S550 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
Q49A88 | CCDC14 | S798 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
Q5BKX5 | ACTMAP | S316 | ochoa | Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) | Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}. |
Q5JTD0 | TJAP1 | S214 | ochoa | Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) | Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}. |
Q5T8I9 | HENMT1 | S329 | ochoa | Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}. |
Q5VWN6 | TASOR2 | S384 | ochoa | Protein TASOR 2 | None |
Q5VZ89 | DENND4C | S741 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q68CZ2 | TNS3 | S976 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
Q68D85 | NCR3LG1 | S397 | ochoa | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}. |
Q68DA7 | FMN1 | S842 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
Q6DT37 | CDC42BPG | S480 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
Q6IQ26 | DENND5A | S1096 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
Q6NV74 | CRACDL | S185 | ochoa | CRACD-like protein | None |
Q6PJG6 | BRAT1 | S742 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
Q6UB99 | ANKRD11 | S1509 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q76I76 | SSH2 | S1227 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
Q7L2J0 | MEPCE | S330 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
Q7Z340 | ZNF551 | S126 | ochoa | Zinc finger protein 551 (Zinc finger protein KOX23) | May be involved in transcriptional regulation. |
Q7Z401 | DENND4A | S731 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q8IUG5 | MYO18B | S2193 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
Q8IV31 | TMEM139 | S155 | ochoa | Transmembrane protein 139 | May be involved in cellular trafficking of proteins such as SLC4A1. {ECO:0000305|PubMed:26049106}. |
Q8IV32 | CCDC71 | S208 | ochoa | Coiled-coil domain-containing protein 71 | None |
Q8IV32 | CCDC71 | S264 | ochoa | Coiled-coil domain-containing protein 71 | None |
Q8IZD4 | DCP1B | S283 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
Q8IZD4 | DCP1B | S448 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
Q8IZE3 | SCYL3 | S707 | ochoa | Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) | May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}. |
Q8N111 | CEND1 | S87 | ochoa | Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen) | Involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9JKC6}. |
Q8NBZ0 | INO80E | S154 | ochoa|psp | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
Q8NFH5 | NUP35 | S121 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
Q8TED9 | AFAP1L1 | S149 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
Q8TEW8 | PARD3B | S1184 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
Q8WYB5 | KAT6B | S371 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
Q92793 | CREBBP | S1763 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
Q92879 | CELF1 | S179 | ochoa|psp | CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. |
Q96A22 | C11orf52 | S85 | ochoa | Uncharacterized protein C11orf52 | None |
Q96AC1 | FERMT2 | S523 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
Q96CM3 | RPUSD4 | S221 | ochoa | Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677, ECO:0000269|PubMed:35051350}. |
Q96CU9 | FOXRED1 | S189 | ochoa | FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) | Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}. |
Q96E22 | NUS1 | S168 | ochoa | Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466, ECO:0000269|PubMed:33077723}. |
Q96HA7 | TONSL | S719 | ochoa | Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) | Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:27338793, PubMed:29478807). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30773278}. |
Q96L91 | EP400 | S2476 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Q96N67 | DOCK7 | S864 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
Q96RG2 | PASK | S843 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
Q96RU2 | USP28 | S113 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
Q99081 | TCF12 | S142 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
Q99717 | SMAD5 | S152 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
Q9BSI4 | TINF2 | S295 | ochoa|psp | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}. |
Q9BWE0 | REPIN1 | S27 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
Q9BWF2 | TRAIP | S295 | ochoa | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}. |
Q9BWN1 | PRR14 | S162 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
Q9BY89 | KIAA1671 | S1312 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BYN7 | ZNF341 | S295 | ochoa | Zinc finger protein 341 | Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. {ECO:0000269|PubMed:29907690, ECO:0000269|PubMed:29907691}. |
Q9C0D5 | TANC1 | S85 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Q9C0K0 | BCL11B | S129 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9H0F5 | RNF38 | S60 | ochoa | E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38) | Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269|PubMed:23973461}. |
Q9H116 | GZF1 | S265 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
Q9H2M9 | RAB3GAP2 | S450 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
Q9H706 | GAREM1 | S356 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
Q9H9P5 | UNKL | S327 | ochoa | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}. |
Q9HAS0 | C17orf75 | S59 | ochoa | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
Q9HCC9 | ZFYVE28 | S523 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
Q9HDC5 | JPH1 | S185 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
Q9NP73 | ALG13 | S830 | ochoa | UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) | Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:22492991}.; FUNCTION: [Isoform 2]: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:16100110, ECO:0000269|PubMed:36200043}.; FUNCTION: [Isoform 1]: No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme. {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36200043}. |
Q9NS62 | THSD1 | S791 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
Q9NYF5 | FAM13B | S760 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
Q9NZC9 | SMARCAL1 | S652 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
Q9P107 | GMIP | S243 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P203 | BTBD7 | S722 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
Q9P242 | NYAP2 | S379 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
Q9P2A4 | ABI3 | S161 | ochoa | ABI gene family member 3 (New molecule including SH3) (Nesh) | May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}. |
Q9UBT2 | UBA2 | S207 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
Q9UGP5 | POLL | S230 | psp | DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) | DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}. |
Q9UGU0 | TCF20 | S871 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
Q9UIF8 | BAZ2B | S1680 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
Q9UII2 | ATP5IF1 | S27 | psp | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. |
Q9UIS9 | MBD1 | S37 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
Q9UKK3 | PARP4 | S1335 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
Q9UKL3 | CASP8AP2 | S20 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
Q9ULD2 | MTUS1 | S752 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9UNZ2 | NSFL1C | S114 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
Q9UPU5 | USP24 | S1612 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
Q9Y286 | SIGLEC7 | S406 | ochoa | Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}. |
Q9Y2H5 | PLEKHA6 | S384 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y4F3 | MARF1 | S827 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
Q9Y5A7 | NUB1 | S489 | ochoa | NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}. |
Q9Y6X0 | SETBP1 | S611 | ochoa | SET-binding protein (SEB) | None |
O00444 | PLK4 | S499 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
P17174 | GOT1 | S93 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
Q13164 | MAPK7 | S210 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.000109 | 3.961 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.000199 | 3.700 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.000262 | 3.581 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.000641 | 3.193 |
R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000716 | 3.145 |
R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.002529 | 2.597 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.002529 | 2.597 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.003414 | 2.467 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.003414 | 2.467 |
R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.004424 | 2.354 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.005470 | 2.262 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.005555 | 2.255 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.005555 | 2.255 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.007776 | 2.109 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.007776 | 2.109 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.007776 | 2.109 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.006804 | 2.167 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.009643 | 2.016 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.009643 | 2.016 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.011014 | 1.958 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.010024 | 1.999 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.010841 | 1.965 |
R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.012098 | 1.917 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.014713 | 1.832 |
R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.014713 | 1.832 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.014713 | 1.832 |
R-HSA-1234174 | Cellular response to hypoxia | 0.012670 | 1.897 |
R-HSA-3214847 | HATs acetylate histones | 0.011657 | 1.933 |
R-HSA-8939211 | ESR-mediated signaling | 0.014132 | 1.850 |
R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.014713 | 1.832 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.016608 | 1.780 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.016608 | 1.780 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.016608 | 1.780 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.017127 | 1.766 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.018601 | 1.730 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.019155 | 1.718 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.018601 | 1.730 |
R-HSA-4839726 | Chromatin organization | 0.018043 | 1.744 |
R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.018601 | 1.730 |
R-HSA-196780 | Biotin transport and metabolism | 0.022871 | 1.641 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.022871 | 1.641 |
R-HSA-198765 | Signalling to ERK5 | 0.047526 | 1.323 |
R-HSA-3560796 | Defective PAPSS2 causes SEMD-PA | 0.047526 | 1.323 |
R-HSA-4755609 | Defective DHDDS causes RP59 | 0.047526 | 1.323 |
R-HSA-5633231 | Defective ALG14 causes ALG14-CMS | 0.047526 | 1.323 |
R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.059052 | 1.229 |
R-HSA-5579006 | Defective GSS causes GSS deficiency | 0.059052 | 1.229 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.059052 | 1.229 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.059052 | 1.229 |
R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.081690 | 1.088 |
R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.081690 | 1.088 |
R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.092805 | 1.032 |
R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.092805 | 1.032 |
R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.103785 | 0.984 |
R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.103785 | 0.984 |
R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.114634 | 0.941 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.135941 | 0.867 |
R-HSA-9700645 | ALK mutants bind TKIs | 0.135941 | 0.867 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.046284 | 1.335 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.156738 | 0.805 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.156738 | 0.805 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.156738 | 0.805 |
R-HSA-429947 | Deadenylation of mRNA | 0.052309 | 1.281 |
R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.166948 | 0.777 |
R-HSA-202670 | ERKs are inactivated | 0.166948 | 0.777 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.166948 | 0.777 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.166948 | 0.777 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.177036 | 0.752 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.177036 | 0.752 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.177036 | 0.752 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.177036 | 0.752 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.177036 | 0.752 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.177036 | 0.752 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.206576 | 0.685 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.235061 | 0.629 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.060571 | 1.218 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.262528 | 0.581 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.280292 | 0.552 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.331070 | 0.480 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.331070 | 0.480 |
R-HSA-171306 | Packaging Of Telomere Ends | 0.331070 | 0.480 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.355106 | 0.450 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.362926 | 0.440 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.362926 | 0.440 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.259042 | 0.587 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.281483 | 0.551 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.299401 | 0.524 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.330565 | 0.481 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.126398 | 0.898 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.339404 | 0.469 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.331070 | 0.480 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.289014 | 0.539 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.339180 | 0.470 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.322862 | 0.491 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.355106 | 0.450 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.114634 | 0.941 |
R-HSA-190873 | Gap junction degradation | 0.135941 | 0.867 |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.187003 | 0.728 |
R-HSA-174430 | Telomere C-strand synthesis initiation | 0.206576 | 0.685 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.225681 | 0.647 |
R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.081690 | 1.088 |
R-HSA-8849472 | PTK6 Down-Regulation | 0.081690 | 1.088 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.033111 | 1.480 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.124533 | 0.905 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.314553 | 0.502 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.042765 | 1.369 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.054421 | 1.264 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.054421 | 1.264 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.355106 | 0.450 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.086056 | 1.065 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.051112 | 1.291 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.051112 | 1.291 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.051112 | 1.291 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.051112 | 1.291 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.116537 | 0.934 |
R-HSA-198753 | ERK/MAPK targets | 0.271464 | 0.566 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.170521 | 0.768 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.245584 | 0.610 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.078874 | 1.103 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.135941 | 0.867 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.149247 | 0.826 |
R-HSA-201451 | Signaling by BMP | 0.061833 | 1.209 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.043153 | 1.365 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.059052 | 1.229 |
R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.092805 | 1.032 |
R-HSA-196025 | Formation of annular gap junctions | 0.125352 | 0.902 |
R-HSA-163615 | PKA activation | 0.032477 | 1.488 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.032477 | 1.488 |
R-HSA-4839744 | Signaling by APC mutants | 0.156738 | 0.805 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.166948 | 0.777 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.187003 | 0.728 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.089718 | 1.047 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.049313 | 1.307 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.280292 | 0.552 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.161948 | 0.791 |
R-HSA-111471 | Apoptotic factor-mediated response | 0.244328 | 0.612 |
R-HSA-5689603 | UCH proteinases | 0.272508 | 0.565 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.125352 | 0.902 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.244328 | 0.612 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.262528 | 0.581 |
R-HSA-9843745 | Adipogenesis | 0.034911 | 1.457 |
R-HSA-9909396 | Circadian clock | 0.269507 | 0.569 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.060187 | 1.221 |
R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.125352 | 0.902 |
R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.146402 | 0.834 |
R-HSA-174362 | Transport and metabolism of PAPS | 0.206576 | 0.685 |
R-HSA-5632684 | Hedgehog 'on' state | 0.250068 | 0.602 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.254554 | 0.594 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.116537 | 0.934 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.236628 | 0.626 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.254554 | 0.594 |
R-HSA-5610787 | Hedgehog 'off' state | 0.047753 | 1.321 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.196849 | 0.706 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.225681 | 0.647 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.244328 | 0.612 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.271464 | 0.566 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.308335 | 0.511 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.254554 | 0.594 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.102098 | 0.991 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.100971 | 0.996 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.051112 | 1.291 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.083989 | 1.076 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.297631 | 0.526 |
R-HSA-5358351 | Signaling by Hedgehog | 0.122100 | 0.913 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.040537 | 1.392 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.100971 | 0.996 |
R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 0.235061 | 0.629 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.262528 | 0.581 |
R-HSA-193648 | NRAGE signals death through JNK | 0.183516 | 0.736 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.345446 | 0.462 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.027503 | 1.561 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.183516 | 0.736 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.051112 | 1.291 |
R-HSA-2262752 | Cellular responses to stress | 0.284744 | 0.546 |
R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.081690 | 1.088 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.025143 | 1.600 |
R-HSA-8948747 | Regulation of PTEN localization | 0.114634 | 0.941 |
R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.114634 | 0.941 |
R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.052309 | 1.281 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.166948 | 0.777 |
R-HSA-9839394 | TGFBR3 expression | 0.055421 | 1.256 |
R-HSA-877312 | Regulation of IFNG signaling | 0.177036 | 0.752 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.187003 | 0.728 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.187003 | 0.728 |
R-HSA-432047 | Passive transport by Aquaporins | 0.225681 | 0.647 |
R-HSA-8875878 | MET promotes cell motility | 0.104805 | 0.980 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.253483 | 0.596 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.331070 | 0.480 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.347191 | 0.459 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.047547 | 1.323 |
R-HSA-195721 | Signaling by WNT | 0.193271 | 0.714 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.177036 | 0.752 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.209897 | 0.678 |
R-HSA-8953897 | Cellular responses to stimuli | 0.178833 | 0.748 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.087559 | 1.058 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.114634 | 0.941 |
R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.156738 | 0.805 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.206576 | 0.685 |
R-HSA-3371568 | Attenuation phase | 0.112590 | 0.949 |
R-HSA-9634597 | GPER1 signaling | 0.149247 | 0.826 |
R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.289014 | 0.539 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.314553 | 0.502 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.322862 | 0.491 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.370651 | 0.431 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.070786 | 1.150 |
R-HSA-73887 | Death Receptor Signaling | 0.348753 | 0.457 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.052309 | 1.281 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.225681 | 0.647 |
R-HSA-8963693 | Aspartate and asparagine metabolism | 0.362926 | 0.440 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.097973 | 1.009 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.218777 | 0.660 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.081784 | 1.087 |
R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.135941 | 0.867 |
R-HSA-9627069 | Regulation of the apoptosome activity | 0.146402 | 0.834 |
R-HSA-6793080 | rRNA modification in the mitochondrion | 0.187003 | 0.728 |
R-HSA-180024 | DARPP-32 events | 0.068484 | 1.164 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.075358 | 1.123 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.086056 | 1.065 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.093426 | 1.030 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.225681 | 0.647 |
R-HSA-209905 | Catecholamine biosynthesis | 0.235061 | 0.629 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.136764 | 0.864 |
R-HSA-5689901 | Metalloprotease DUBs | 0.322862 | 0.491 |
R-HSA-77387 | Insulin receptor recycling | 0.339180 | 0.470 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.276996 | 0.558 |
R-HSA-445717 | Aquaporin-mediated transport | 0.052942 | 1.276 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.294927 | 0.530 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.314553 | 0.502 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.037071 | 1.431 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.214333 | 0.669 |
R-HSA-8848021 | Signaling by PTK6 | 0.214333 | 0.669 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.314553 | 0.502 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.314553 | 0.502 |
R-HSA-9856872 | Malate-aspartate shuttle | 0.196849 | 0.706 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.206576 | 0.685 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.028694 | 1.542 |
R-HSA-1237112 | Methionine salvage pathway | 0.253483 | 0.596 |
R-HSA-525793 | Myogenesis | 0.322862 | 0.491 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.339180 | 0.470 |
R-HSA-5688426 | Deubiquitination | 0.052582 | 1.279 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.086929 | 1.061 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.086929 | 1.061 |
R-HSA-73884 | Base Excision Repair | 0.339404 | 0.469 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.071894 | 1.143 |
R-HSA-9031628 | NGF-stimulated transcription | 0.031673 | 1.499 |
R-HSA-74160 | Gene expression (Transcription) | 0.303304 | 0.518 |
R-HSA-156711 | Polo-like kinase mediated events | 0.244328 | 0.612 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.136764 | 0.864 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.365694 | 0.437 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.097177 | 1.012 |
R-HSA-9937008 | Mitochondrial mRNA modification | 0.297631 | 0.526 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.161948 | 0.791 |
R-HSA-70635 | Urea cycle | 0.322862 | 0.491 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.268019 | 0.572 |
R-HSA-5689880 | Ub-specific processing proteases | 0.207385 | 0.683 |
R-HSA-9707616 | Heme signaling | 0.054803 | 1.261 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.040537 | 1.392 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.098479 | 1.007 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.259042 | 0.587 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.135941 | 0.867 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.040537 | 1.392 |
R-HSA-9683610 | Maturation of nucleoprotein | 0.187003 | 0.728 |
R-HSA-8876725 | Protein methylation | 0.206576 | 0.685 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.253483 | 0.596 |
R-HSA-174403 | Glutathione synthesis and recycling | 0.280292 | 0.552 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.227690 | 0.643 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.105583 | 0.976 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.250068 | 0.602 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.343811 | 0.464 |
R-HSA-982772 | Growth hormone receptor signaling | 0.297631 | 0.526 |
R-HSA-9614085 | FOXO-mediated transcription | 0.046477 | 1.333 |
R-HSA-114452 | Activation of BH3-only proteins | 0.355106 | 0.450 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.123646 | 0.908 |
R-HSA-111458 | Formation of apoptosome | 0.146402 | 0.834 |
R-HSA-200425 | Carnitine shuttle | 0.297631 | 0.526 |
R-HSA-73614 | Pyrimidine salvage | 0.339180 | 0.470 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.308335 | 0.511 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.212422 | 0.673 |
R-HSA-446728 | Cell junction organization | 0.073672 | 1.133 |
R-HSA-418990 | Adherens junctions interactions | 0.166375 | 0.779 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.032477 | 1.488 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.206576 | 0.685 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.322862 | 0.491 |
R-HSA-421270 | Cell-cell junction organization | 0.236045 | 0.627 |
R-HSA-9006936 | Signaling by TGFB family members | 0.173207 | 0.761 |
R-HSA-111933 | Calmodulin induced events | 0.097177 | 1.012 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.140899 | 0.851 |
R-HSA-9007101 | Rab regulation of trafficking | 0.077266 | 1.112 |
R-HSA-111997 | CaM pathway | 0.097177 | 1.012 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.124533 | 0.905 |
R-HSA-6807004 | Negative regulation of MET activity | 0.262528 | 0.581 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.179168 | 0.747 |
R-HSA-1500931 | Cell-Cell communication | 0.118025 | 0.928 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.331070 | 0.480 |
R-HSA-6806834 | Signaling by MET | 0.093333 | 1.030 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.058597 | 1.232 |
R-HSA-111996 | Ca-dependent events | 0.124533 | 0.905 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.208269 | 0.681 |
R-HSA-166520 | Signaling by NTRKs | 0.145664 | 0.837 |
R-HSA-69205 | G1/S-Specific Transcription | 0.097177 | 1.012 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.253483 | 0.596 |
R-HSA-1489509 | DAG and IP3 signaling | 0.136764 | 0.864 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.289014 | 0.539 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.187880 | 0.726 |
R-HSA-163685 | Integration of energy metabolism | 0.040287 | 1.395 |
R-HSA-3781865 | Diseases of glycosylation | 0.235491 | 0.628 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.205470 | 0.687 |
R-HSA-3371556 | Cellular response to heat stress | 0.227461 | 0.643 |
R-HSA-8983711 | OAS antiviral response | 0.177036 | 0.752 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.290449 | 0.537 |
R-HSA-112043 | PLC beta mediated events | 0.205470 | 0.687 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.112590 | 0.949 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.165917 | 0.780 |
R-HSA-8957322 | Metabolism of steroids | 0.128823 | 0.890 |
R-HSA-438064 | Post NMDA receptor activation events | 0.326133 | 0.487 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.263530 | 0.579 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.199173 | 0.701 |
R-HSA-112040 | G-protein mediated events | 0.232156 | 0.634 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.052309 | 1.281 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.052309 | 1.281 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.358663 | 0.445 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.348753 | 0.457 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.061833 | 1.209 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.315808 | 0.501 |
R-HSA-186712 | Regulation of beta-cell development | 0.196651 | 0.706 |
R-HSA-1236394 | Signaling by ERBB4 | 0.263530 | 0.579 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.245807 | 0.609 |
R-HSA-2028269 | Signaling by Hippo | 0.235061 | 0.629 |
R-HSA-9645723 | Diseases of programmed cell death | 0.330565 | 0.481 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.343811 | 0.464 |
R-HSA-9607240 | FLT3 Signaling | 0.116537 | 0.934 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.132658 | 0.877 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.245584 | 0.610 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.378283 | 0.422 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.378283 | 0.422 |
R-HSA-5083635 | Defective B3GALTL causes PpS | 0.378283 | 0.422 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.378283 | 0.422 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.378283 | 0.422 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.378283 | 0.422 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.378283 | 0.422 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.378283 | 0.422 |
R-HSA-9733709 | Cardiogenesis | 0.378283 | 0.422 |
R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.378283 | 0.422 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.378283 | 0.422 |
R-HSA-354192 | Integrin signaling | 0.378283 | 0.422 |
R-HSA-422356 | Regulation of insulin secretion | 0.383000 | 0.417 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.385823 | 0.414 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.385823 | 0.414 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.385823 | 0.414 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.385823 | 0.414 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.387296 | 0.412 |
R-HSA-597592 | Post-translational protein modification | 0.391819 | 0.407 |
R-HSA-180746 | Nuclear import of Rev protein | 0.393271 | 0.405 |
R-HSA-1980145 | Signaling by NOTCH2 | 0.393271 | 0.405 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.393271 | 0.405 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.393271 | 0.405 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.393271 | 0.405 |
R-HSA-1483255 | PI Metabolism | 0.400103 | 0.398 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.400103 | 0.398 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.400630 | 0.397 |
R-HSA-381042 | PERK regulates gene expression | 0.400630 | 0.397 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.400630 | 0.397 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.400630 | 0.397 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.407901 | 0.389 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.407901 | 0.389 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.407901 | 0.389 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.407901 | 0.389 |
R-HSA-8853659 | RET signaling | 0.407901 | 0.389 |
R-HSA-111885 | Opioid Signalling | 0.408571 | 0.389 |
R-HSA-9833110 | RSV-host interactions | 0.412784 | 0.384 |
R-HSA-4641257 | Degradation of AXIN | 0.415083 | 0.382 |
R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.415083 | 0.382 |
R-HSA-1296072 | Voltage gated Potassium channels | 0.415083 | 0.382 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.415083 | 0.382 |
R-HSA-110331 | Cleavage of the damaged purine | 0.415083 | 0.382 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.415083 | 0.382 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.416982 | 0.380 |
R-HSA-73927 | Depurination | 0.422179 | 0.375 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.422179 | 0.375 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.422179 | 0.375 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.422179 | 0.375 |
R-HSA-211000 | Gene Silencing by RNA | 0.425333 | 0.371 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.429189 | 0.367 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.429189 | 0.367 |
R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.429189 | 0.367 |
R-HSA-201556 | Signaling by ALK | 0.429189 | 0.367 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.429485 | 0.367 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.436114 | 0.360 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.436114 | 0.360 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.436114 | 0.360 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.436114 | 0.360 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.436114 | 0.360 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.436114 | 0.360 |
R-HSA-8868766 | rRNA processing in the mitochondrion | 0.436114 | 0.360 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.436114 | 0.360 |
R-HSA-2559583 | Cellular Senescence | 0.436752 | 0.360 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.442956 | 0.354 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.442956 | 0.354 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.449716 | 0.347 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.449716 | 0.347 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.449716 | 0.347 |
R-HSA-9683701 | Translation of Structural Proteins | 0.449716 | 0.347 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.450005 | 0.347 |
R-HSA-69275 | G2/M Transition | 0.455766 | 0.341 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.456393 | 0.341 |
R-HSA-73928 | Depyrimidination | 0.456393 | 0.341 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.462045 | 0.335 |
R-HSA-73621 | Pyrimidine catabolism | 0.462990 | 0.334 |
R-HSA-5668914 | Diseases of metabolism | 0.464087 | 0.333 |
R-HSA-190828 | Gap junction trafficking | 0.469508 | 0.328 |
R-HSA-373760 | L1CAM interactions | 0.470104 | 0.328 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.474072 | 0.324 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.475946 | 0.322 |
R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.475946 | 0.322 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.475946 | 0.322 |
R-HSA-5693538 | Homology Directed Repair | 0.478021 | 0.321 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.481953 | 0.317 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.482307 | 0.317 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.482307 | 0.317 |
R-HSA-68875 | Mitotic Prophase | 0.485866 | 0.313 |
R-HSA-437239 | Recycling pathway of L1 | 0.488591 | 0.311 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.489761 | 0.310 |
R-HSA-73894 | DNA Repair | 0.492883 | 0.307 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.500933 | 0.300 |
R-HSA-9766229 | Degradation of CDH1 | 0.500933 | 0.300 |
R-HSA-69206 | G1/S Transition | 0.508958 | 0.293 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.512741 | 0.290 |
R-HSA-69481 | G2/M Checkpoints | 0.516505 | 0.287 |
R-HSA-114608 | Platelet degranulation | 0.516505 | 0.287 |
R-HSA-68949 | Orc1 removal from chromatin | 0.518892 | 0.285 |
R-HSA-72187 | mRNA 3'-end processing | 0.518892 | 0.285 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.518892 | 0.285 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.518892 | 0.285 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.518892 | 0.285 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.524734 | 0.280 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.524734 | 0.280 |
R-HSA-1221632 | Meiotic synapsis | 0.524734 | 0.280 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.524734 | 0.280 |
R-HSA-1640170 | Cell Cycle | 0.530224 | 0.276 |
R-HSA-72649 | Translation initiation complex formation | 0.530505 | 0.275 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.530505 | 0.275 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.535033 | 0.272 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.536207 | 0.271 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.538681 | 0.269 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.541840 | 0.266 |
R-HSA-75893 | TNF signaling | 0.541840 | 0.266 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.541840 | 0.266 |
R-HSA-5578775 | Ion homeostasis | 0.541840 | 0.266 |
R-HSA-209776 | Metabolism of amine-derived hormones | 0.541840 | 0.266 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.541840 | 0.266 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.542308 | 0.266 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.547405 | 0.262 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.547405 | 0.262 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.552903 | 0.257 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.552903 | 0.257 |
R-HSA-180786 | Extension of Telomeres | 0.558334 | 0.253 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.558334 | 0.253 |
R-HSA-191859 | snRNP Assembly | 0.558334 | 0.253 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.558334 | 0.253 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.560150 | 0.252 |
R-HSA-983189 | Kinesins | 0.563700 | 0.249 |
R-HSA-156590 | Glutathione conjugation | 0.563700 | 0.249 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.569000 | 0.245 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.569000 | 0.245 |
R-HSA-450294 | MAP kinase activation | 0.569000 | 0.245 |
R-HSA-8956321 | Nucleotide salvage | 0.569000 | 0.245 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.574237 | 0.241 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.574237 | 0.241 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.574734 | 0.241 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.579410 | 0.237 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.579410 | 0.237 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.579410 | 0.237 |
R-HSA-6799198 | Complex I biogenesis | 0.579410 | 0.237 |
R-HSA-373755 | Semaphorin interactions | 0.579410 | 0.237 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.580901 | 0.236 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.584290 | 0.233 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.588157 | 0.231 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.594334 | 0.226 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.594558 | 0.226 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.595373 | 0.225 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.599486 | 0.222 |
R-HSA-196807 | Nicotinate metabolism | 0.599486 | 0.222 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.600929 | 0.221 |
R-HSA-9758941 | Gastrulation | 0.604196 | 0.219 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.604354 | 0.219 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.604354 | 0.219 |
R-HSA-5218859 | Regulated Necrosis | 0.604354 | 0.219 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.607444 | 0.216 |
R-HSA-162582 | Signal Transduction | 0.608822 | 0.216 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.610671 | 0.214 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.613914 | 0.212 |
R-HSA-448424 | Interleukin-17 signaling | 0.613914 | 0.212 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.613914 | 0.212 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.614240 | 0.212 |
R-HSA-157118 | Signaling by NOTCH | 0.614670 | 0.211 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.618608 | 0.209 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.618608 | 0.209 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.623244 | 0.205 |
R-HSA-1989781 | PPARA activates gene expression | 0.623378 | 0.205 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.627825 | 0.202 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.627825 | 0.202 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.629611 | 0.201 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.632350 | 0.199 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.632350 | 0.199 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.632350 | 0.199 |
R-HSA-380287 | Centrosome maturation | 0.636821 | 0.196 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.636821 | 0.196 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.636821 | 0.196 |
R-HSA-212436 | Generic Transcription Pathway | 0.643624 | 0.191 |
R-HSA-109581 | Apoptosis | 0.644845 | 0.191 |
R-HSA-9694635 | Translation of Structural Proteins | 0.645600 | 0.190 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.649911 | 0.187 |
R-HSA-191273 | Cholesterol biosynthesis | 0.649911 | 0.187 |
R-HSA-9659379 | Sensory processing of sound | 0.654169 | 0.184 |
R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.654169 | 0.184 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.658375 | 0.182 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.662531 | 0.179 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.666636 | 0.176 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.670692 | 0.173 |
R-HSA-418555 | G alpha (s) signalling events | 0.673827 | 0.171 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.673827 | 0.171 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.674698 | 0.171 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.676617 | 0.170 |
R-HSA-1500620 | Meiosis | 0.678656 | 0.168 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.679389 | 0.168 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.679389 | 0.168 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.684873 | 0.164 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.686429 | 0.163 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.686429 | 0.163 |
R-HSA-1614635 | Sulfur amino acid metabolism | 0.686429 | 0.163 |
R-HSA-611105 | Respiratory electron transport | 0.692957 | 0.159 |
R-HSA-156902 | Peptide chain elongation | 0.694015 | 0.159 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.696020 | 0.157 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.708643 | 0.150 |
R-HSA-199991 | Membrane Trafficking | 0.709117 | 0.149 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.712190 | 0.147 |
R-HSA-74752 | Signaling by Insulin receptor | 0.712190 | 0.147 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.712190 | 0.147 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.715695 | 0.145 |
R-HSA-983712 | Ion channel transport | 0.721149 | 0.142 |
R-HSA-5617833 | Cilium Assembly | 0.723601 | 0.141 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.726035 | 0.139 |
R-HSA-913531 | Interferon Signaling | 0.726710 | 0.139 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.728452 | 0.138 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.729291 | 0.137 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.729291 | 0.137 |
R-HSA-1296071 | Potassium Channels | 0.729291 | 0.137 |
R-HSA-68877 | Mitotic Prometaphase | 0.730850 | 0.136 |
R-HSA-157579 | Telomere Maintenance | 0.732588 | 0.135 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.732588 | 0.135 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.735845 | 0.133 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.735845 | 0.133 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.735845 | 0.133 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.735845 | 0.133 |
R-HSA-70171 | Glycolysis | 0.742241 | 0.129 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.747139 | 0.127 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.747139 | 0.127 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.748483 | 0.126 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.748483 | 0.126 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.751547 | 0.124 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.754574 | 0.122 |
R-HSA-5357801 | Programmed Cell Death | 0.760425 | 0.119 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.760519 | 0.119 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.763437 | 0.117 |
R-HSA-69239 | Synthesis of DNA | 0.766320 | 0.116 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.766320 | 0.116 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.766320 | 0.116 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.769168 | 0.114 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.769168 | 0.114 |
R-HSA-5419276 | Mitochondrial translation termination | 0.771982 | 0.112 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.771982 | 0.112 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.771982 | 0.112 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.774761 | 0.111 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.774761 | 0.111 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.775162 | 0.111 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.780219 | 0.108 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.780219 | 0.108 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.780219 | 0.108 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.782899 | 0.106 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.785546 | 0.105 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.790744 | 0.102 |
R-HSA-8951664 | Neddylation | 0.792946 | 0.101 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.793296 | 0.101 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.793296 | 0.101 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.795816 | 0.099 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.795816 | 0.099 |
R-HSA-70326 | Glucose metabolism | 0.798307 | 0.098 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.803197 | 0.095 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.803197 | 0.095 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.805913 | 0.094 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.807705 | 0.093 |
R-HSA-73886 | Chromosome Maintenance | 0.807969 | 0.093 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.810312 | 0.091 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.810312 | 0.091 |
R-HSA-2132295 | MHC class II antigen presentation | 0.812626 | 0.090 |
R-HSA-72312 | rRNA processing | 0.812995 | 0.090 |
R-HSA-162909 | Host Interactions of HIV factors | 0.814912 | 0.089 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.818814 | 0.087 |
R-HSA-194138 | Signaling by VEGF | 0.819402 | 0.087 |
R-HSA-422475 | Axon guidance | 0.821574 | 0.085 |
R-HSA-8953854 | Metabolism of RNA | 0.822508 | 0.085 |
R-HSA-8956319 | Nucleotide catabolism | 0.828058 | 0.082 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.828696 | 0.082 |
R-HSA-1474165 | Reproduction | 0.832231 | 0.080 |
R-HSA-9679506 | SARS-CoV Infections | 0.832951 | 0.079 |
R-HSA-5576891 | Cardiac conduction | 0.834279 | 0.079 |
R-HSA-5173105 | O-linked glycosylation | 0.847936 | 0.072 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.848333 | 0.071 |
R-HSA-5368287 | Mitochondrial translation | 0.849793 | 0.071 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.850852 | 0.070 |
R-HSA-6807070 | PTEN Regulation | 0.851628 | 0.070 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.853671 | 0.069 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.858747 | 0.066 |
R-HSA-9734767 | Developmental Cell Lineages | 0.860508 | 0.065 |
R-HSA-9675108 | Nervous system development | 0.860755 | 0.065 |
R-HSA-109582 | Hemostasis | 0.863198 | 0.064 |
R-HSA-9711123 | Cellular response to chemical stress | 0.867053 | 0.062 |
R-HSA-69242 | S Phase | 0.868793 | 0.061 |
R-HSA-68886 | M Phase | 0.870391 | 0.060 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.871981 | 0.059 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.875092 | 0.058 |
R-HSA-69306 | DNA Replication | 0.876619 | 0.057 |
R-HSA-9609507 | Protein localization | 0.876619 | 0.057 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.879618 | 0.056 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.880475 | 0.055 |
R-HSA-5653656 | Vesicle-mediated transport | 0.881944 | 0.055 |
R-HSA-9610379 | HCMV Late Events | 0.882545 | 0.054 |
R-HSA-162587 | HIV Life Cycle | 0.882545 | 0.054 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.882778 | 0.054 |
R-HSA-9658195 | Leishmania infection | 0.882778 | 0.054 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.883914 | 0.054 |
R-HSA-9711097 | Cellular response to starvation | 0.883981 | 0.054 |
R-HSA-877300 | Interferon gamma signaling | 0.885400 | 0.053 |
R-HSA-1266738 | Developmental Biology | 0.885600 | 0.053 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.886802 | 0.052 |
R-HSA-392499 | Metabolism of proteins | 0.889852 | 0.051 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.892240 | 0.050 |
R-HSA-5619102 | SLC transporter disorders | 0.896148 | 0.048 |
R-HSA-1483257 | Phospholipid metabolism | 0.897785 | 0.047 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.901140 | 0.045 |
R-HSA-72306 | tRNA processing | 0.901140 | 0.045 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.907817 | 0.042 |
R-HSA-168255 | Influenza Infection | 0.911515 | 0.040 |
R-HSA-72766 | Translation | 0.913264 | 0.039 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.920807 | 0.036 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.921684 | 0.035 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.922599 | 0.035 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.925542 | 0.034 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.926455 | 0.033 |
R-HSA-9609690 | HCMV Early Events | 0.928247 | 0.032 |
R-HSA-376176 | Signaling by ROBO receptors | 0.934185 | 0.030 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.935441 | 0.029 |
R-HSA-72172 | mRNA Splicing | 0.935790 | 0.029 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.936940 | 0.028 |
R-HSA-112316 | Neuronal System | 0.938618 | 0.028 |
R-HSA-397014 | Muscle contraction | 0.941829 | 0.026 |
R-HSA-68882 | Mitotic Anaphase | 0.944633 | 0.025 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.945312 | 0.024 |
R-HSA-162906 | HIV Infection | 0.951669 | 0.022 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.953903 | 0.020 |
R-HSA-15869 | Metabolism of nucleotides | 0.956759 | 0.019 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.958335 | 0.018 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.958457 | 0.018 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.962261 | 0.017 |
R-HSA-9609646 | HCMV Infection | 0.963637 | 0.016 |
R-HSA-418594 | G alpha (i) signalling events | 0.967653 | 0.014 |
R-HSA-416476 | G alpha (q) signalling events | 0.969426 | 0.013 |
R-HSA-1280218 | Adaptive Immune System | 0.977388 | 0.010 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.979185 | 0.009 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.980540 | 0.009 |
R-HSA-449147 | Signaling by Interleukins | 0.986071 | 0.006 |
R-HSA-388396 | GPCR downstream signalling | 0.988443 | 0.005 |
R-HSA-556833 | Metabolism of lipids | 0.990296 | 0.004 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.993702 | 0.003 |
R-HSA-382551 | Transport of small molecules | 0.994510 | 0.002 |
R-HSA-372790 | Signaling by GPCR | 0.994717 | 0.002 |
R-HSA-8978868 | Fatty acid metabolism | 0.994907 | 0.002 |
R-HSA-1643685 | Disease | 0.995402 | 0.002 |
R-HSA-6798695 | Neutrophil degranulation | 0.997277 | 0.001 |
R-HSA-9824446 | Viral Infection Pathways | 0.998604 | 0.001 |
R-HSA-211859 | Biological oxidations | 0.998812 | 0.001 |
R-HSA-5663205 | Infectious disease | 0.999745 | 0.000 |
R-HSA-168249 | Innate Immune System | 0.999813 | 0.000 |
R-HSA-168256 | Immune System | 0.999825 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999988 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CDK19 |
0.872 | 0.830 | 1 | 0.848 |
KIS |
0.872 | 0.784 | 1 | 0.799 |
HIPK2 |
0.871 | 0.796 | 1 | 0.851 |
CDK8 |
0.869 | 0.834 | 1 | 0.817 |
P38G |
0.869 | 0.881 | 1 | 0.890 |
CDK18 |
0.867 | 0.839 | 1 | 0.861 |
CDK17 |
0.867 | 0.860 | 1 | 0.884 |
JNK2 |
0.866 | 0.883 | 1 | 0.859 |
P38D |
0.863 | 0.861 | 1 | 0.901 |
CDK13 |
0.863 | 0.842 | 1 | 0.843 |
DYRK2 |
0.863 | 0.786 | 1 | 0.772 |
CDK7 |
0.862 | 0.820 | 1 | 0.822 |
CDK3 |
0.861 | 0.750 | 1 | 0.878 |
CDK12 |
0.860 | 0.841 | 1 | 0.862 |
CDK1 |
0.860 | 0.818 | 1 | 0.839 |
ERK1 |
0.860 | 0.833 | 1 | 0.841 |
CDK5 |
0.859 | 0.808 | 1 | 0.796 |
JNK3 |
0.858 | 0.872 | 1 | 0.836 |
CDK9 |
0.858 | 0.835 | 1 | 0.836 |
CDK16 |
0.858 | 0.818 | 1 | 0.874 |
DYRK4 |
0.857 | 0.792 | 1 | 0.857 |
P38B |
0.856 | 0.834 | 1 | 0.824 |
DYRK1B |
0.854 | 0.770 | 1 | 0.824 |
CDK10 |
0.852 | 0.782 | 1 | 0.844 |
HIPK4 |
0.851 | 0.530 | 1 | 0.574 |
HIPK1 |
0.851 | 0.728 | 1 | 0.755 |
CLK3 |
0.851 | 0.525 | 1 | 0.533 |
CDK14 |
0.849 | 0.814 | 1 | 0.829 |
ERK2 |
0.848 | 0.835 | 1 | 0.801 |
P38A |
0.847 | 0.805 | 1 | 0.765 |
NLK |
0.845 | 0.757 | 1 | 0.575 |
CDK4 |
0.844 | 0.819 | 1 | 0.871 |
DYRK1A |
0.843 | 0.642 | 1 | 0.738 |
HIPK3 |
0.843 | 0.709 | 1 | 0.732 |
CDK6 |
0.841 | 0.791 | 1 | 0.847 |
SRPK1 |
0.840 | 0.376 | -3 | 0.768 |
DYRK3 |
0.838 | 0.599 | 1 | 0.722 |
JNK1 |
0.836 | 0.778 | 1 | 0.857 |
CLK1 |
0.836 | 0.458 | -3 | 0.753 |
SRPK2 |
0.834 | 0.321 | -3 | 0.694 |
CDK2 |
0.834 | 0.632 | 1 | 0.724 |
CLK2 |
0.832 | 0.451 | -3 | 0.750 |
CLK4 |
0.831 | 0.430 | -3 | 0.772 |
ERK5 |
0.831 | 0.406 | 1 | 0.477 |
MTOR |
0.823 | 0.223 | 1 | 0.367 |
ICK |
0.822 | 0.376 | -3 | 0.859 |
SRPK3 |
0.820 | 0.282 | -3 | 0.737 |
CDKL5 |
0.818 | 0.176 | -3 | 0.823 |
MAK |
0.817 | 0.503 | -2 | 0.751 |
CDKL1 |
0.816 | 0.162 | -3 | 0.825 |
COT |
0.814 | -0.091 | 2 | 0.857 |
PRP4 |
0.814 | 0.492 | -3 | 0.806 |
MOK |
0.811 | 0.481 | 1 | 0.646 |
CDC7 |
0.811 | -0.087 | 1 | 0.194 |
TBK1 |
0.808 | -0.140 | 1 | 0.178 |
GCN2 |
0.808 | -0.141 | 2 | 0.787 |
NDR2 |
0.807 | -0.003 | -3 | 0.844 |
PRKD1 |
0.806 | 0.005 | -3 | 0.857 |
PRPK |
0.806 | -0.103 | -1 | 0.845 |
NEK6 |
0.806 | -0.045 | -2 | 0.867 |
TGFBR2 |
0.805 | -0.026 | -2 | 0.853 |
MOS |
0.805 | -0.043 | 1 | 0.242 |
PIM3 |
0.805 | -0.019 | -3 | 0.839 |
IKKE |
0.804 | -0.152 | 1 | 0.179 |
ATR |
0.804 | -0.047 | 1 | 0.251 |
PRKD2 |
0.804 | 0.028 | -3 | 0.788 |
CAMK1B |
0.804 | -0.011 | -3 | 0.873 |
MST4 |
0.804 | -0.018 | 2 | 0.844 |
BMPR2 |
0.803 | -0.102 | -2 | 0.891 |
RSK2 |
0.803 | 0.026 | -3 | 0.792 |
PKN3 |
0.803 | -0.032 | -3 | 0.842 |
NUAK2 |
0.802 | 0.024 | -3 | 0.835 |
PDHK4 |
0.802 | -0.158 | 1 | 0.261 |
ULK2 |
0.802 | -0.171 | 2 | 0.786 |
NDR1 |
0.801 | -0.024 | -3 | 0.844 |
WNK1 |
0.801 | -0.065 | -2 | 0.878 |
RSK3 |
0.801 | 0.018 | -3 | 0.787 |
DSTYK |
0.800 | -0.134 | 2 | 0.852 |
RAF1 |
0.800 | -0.193 | 1 | 0.196 |
ERK7 |
0.800 | 0.265 | 2 | 0.523 |
PDHK1 |
0.800 | -0.149 | 1 | 0.242 |
CAMLCK |
0.800 | 0.025 | -2 | 0.876 |
P90RSK |
0.800 | 0.019 | -3 | 0.798 |
PKCD |
0.799 | -0.009 | 2 | 0.771 |
AURC |
0.799 | 0.053 | -2 | 0.719 |
NEK7 |
0.799 | -0.141 | -3 | 0.857 |
NIK |
0.798 | -0.048 | -3 | 0.888 |
MARK4 |
0.798 | -0.036 | 4 | 0.835 |
IKKB |
0.797 | -0.185 | -2 | 0.726 |
AMPKA1 |
0.796 | -0.042 | -3 | 0.857 |
PIM1 |
0.796 | 0.033 | -3 | 0.783 |
CHAK2 |
0.796 | -0.061 | -1 | 0.851 |
P70S6KB |
0.796 | 0.025 | -3 | 0.810 |
PKN2 |
0.795 | -0.054 | -3 | 0.843 |
MAPKAPK3 |
0.795 | -0.041 | -3 | 0.800 |
DAPK2 |
0.795 | -0.012 | -3 | 0.883 |
AMPKA2 |
0.795 | -0.016 | -3 | 0.826 |
PKACG |
0.795 | 0.004 | -2 | 0.774 |
WNK3 |
0.794 | -0.159 | 1 | 0.203 |
IRE1 |
0.794 | -0.077 | 1 | 0.201 |
NIM1 |
0.794 | -0.046 | 3 | 0.821 |
SKMLCK |
0.793 | -0.050 | -2 | 0.880 |
ULK1 |
0.793 | -0.157 | -3 | 0.837 |
LATS2 |
0.793 | -0.040 | -5 | 0.767 |
TSSK1 |
0.793 | -0.033 | -3 | 0.877 |
CAMK2G |
0.792 | -0.122 | 2 | 0.771 |
RIPK3 |
0.792 | -0.156 | 3 | 0.759 |
PRKD3 |
0.791 | 0.009 | -3 | 0.759 |
MNK2 |
0.791 | -0.008 | -2 | 0.827 |
IRE2 |
0.791 | -0.058 | 2 | 0.752 |
MAPKAPK2 |
0.791 | -0.023 | -3 | 0.749 |
PAK6 |
0.791 | 0.020 | -2 | 0.751 |
MLK1 |
0.790 | -0.168 | 2 | 0.798 |
NEK9 |
0.790 | -0.165 | 2 | 0.835 |
PAK3 |
0.790 | -0.033 | -2 | 0.814 |
BCKDK |
0.790 | -0.151 | -1 | 0.808 |
NUAK1 |
0.789 | -0.024 | -3 | 0.797 |
ALK4 |
0.789 | -0.018 | -2 | 0.866 |
HUNK |
0.789 | -0.164 | 2 | 0.790 |
PHKG1 |
0.789 | -0.056 | -3 | 0.833 |
AURB |
0.789 | 0.028 | -2 | 0.713 |
MLK2 |
0.788 | -0.127 | 2 | 0.818 |
MELK |
0.788 | -0.054 | -3 | 0.822 |
DNAPK |
0.788 | -0.037 | 1 | 0.250 |
PINK1 |
0.788 | 0.170 | 1 | 0.408 |
PAK1 |
0.788 | -0.022 | -2 | 0.817 |
ATM |
0.788 | -0.073 | 1 | 0.218 |
LATS1 |
0.788 | 0.008 | -3 | 0.866 |
GRK5 |
0.787 | -0.170 | -3 | 0.850 |
BMPR1B |
0.787 | -0.028 | 1 | 0.149 |
TSSK2 |
0.787 | -0.086 | -5 | 0.834 |
CAMK2D |
0.787 | -0.109 | -3 | 0.865 |
QSK |
0.787 | -0.012 | 4 | 0.816 |
PKR |
0.787 | -0.064 | 1 | 0.222 |
IKKA |
0.786 | -0.112 | -2 | 0.710 |
TGFBR1 |
0.786 | -0.023 | -2 | 0.843 |
PKCB |
0.786 | -0.034 | 2 | 0.723 |
VRK2 |
0.786 | 0.068 | 1 | 0.297 |
AKT2 |
0.786 | 0.053 | -3 | 0.696 |
PKACB |
0.786 | 0.044 | -2 | 0.729 |
PKCA |
0.786 | -0.021 | 2 | 0.712 |
SGK3 |
0.785 | 0.021 | -3 | 0.777 |
PKG2 |
0.785 | 0.020 | -2 | 0.726 |
ANKRD3 |
0.785 | -0.168 | 1 | 0.214 |
NEK2 |
0.785 | -0.114 | 2 | 0.812 |
MLK3 |
0.785 | -0.083 | 2 | 0.719 |
MSK2 |
0.785 | -0.019 | -3 | 0.764 |
RIPK1 |
0.784 | -0.190 | 1 | 0.190 |
SMG1 |
0.784 | -0.056 | 1 | 0.241 |
MNK1 |
0.784 | -0.010 | -2 | 0.834 |
MASTL |
0.784 | -0.200 | -2 | 0.797 |
MPSK1 |
0.784 | 0.049 | 1 | 0.262 |
RSK4 |
0.784 | 0.023 | -3 | 0.751 |
PKCZ |
0.783 | -0.045 | 2 | 0.773 |
CAMK4 |
0.783 | -0.101 | -3 | 0.822 |
GSK3A |
0.783 | 0.195 | 4 | 0.454 |
QIK |
0.783 | -0.081 | -3 | 0.844 |
SIK |
0.783 | -0.024 | -3 | 0.766 |
GRK1 |
0.782 | -0.073 | -2 | 0.767 |
GRK7 |
0.782 | -0.009 | 1 | 0.204 |
PIM2 |
0.782 | 0.045 | -3 | 0.762 |
PKCG |
0.782 | -0.049 | 2 | 0.711 |
PKCH |
0.781 | -0.053 | 2 | 0.707 |
PAK2 |
0.780 | -0.041 | -2 | 0.801 |
YSK4 |
0.780 | -0.155 | 1 | 0.178 |
DLK |
0.780 | -0.232 | 1 | 0.196 |
BRSK2 |
0.780 | -0.077 | -3 | 0.830 |
PLK1 |
0.780 | -0.125 | -2 | 0.828 |
GRK6 |
0.780 | -0.159 | 1 | 0.180 |
HRI |
0.780 | -0.104 | -2 | 0.877 |
TLK2 |
0.780 | -0.097 | 1 | 0.199 |
CHAK1 |
0.779 | -0.137 | 2 | 0.782 |
AKT1 |
0.779 | 0.039 | -3 | 0.715 |
MSK1 |
0.779 | 0.001 | -3 | 0.767 |
ACVR2A |
0.779 | -0.064 | -2 | 0.842 |
PRKX |
0.779 | 0.051 | -3 | 0.668 |
PERK |
0.779 | -0.095 | -2 | 0.866 |
TTBK2 |
0.778 | -0.206 | 2 | 0.695 |
MARK3 |
0.778 | -0.025 | 4 | 0.786 |
ACVR2B |
0.777 | -0.070 | -2 | 0.845 |
MARK2 |
0.777 | -0.034 | 4 | 0.750 |
MEK1 |
0.777 | -0.143 | 2 | 0.827 |
BRSK1 |
0.777 | -0.059 | -3 | 0.800 |
DCAMKL1 |
0.776 | -0.036 | -3 | 0.785 |
AURA |
0.776 | 0.008 | -2 | 0.689 |
CHK1 |
0.776 | -0.072 | -3 | 0.842 |
MYLK4 |
0.776 | -0.018 | -2 | 0.811 |
ALK2 |
0.775 | -0.056 | -2 | 0.845 |
PKCT |
0.775 | -0.039 | 2 | 0.722 |
WNK4 |
0.775 | -0.102 | -2 | 0.863 |
GRK4 |
0.775 | -0.183 | -2 | 0.814 |
CAMK2B |
0.774 | -0.085 | 2 | 0.732 |
P70S6K |
0.774 | 0.011 | -3 | 0.733 |
PHKG2 |
0.774 | -0.070 | -3 | 0.800 |
PLK4 |
0.773 | -0.121 | 2 | 0.628 |
CAMK2A |
0.773 | -0.054 | 2 | 0.745 |
MAPKAPK5 |
0.773 | -0.083 | -3 | 0.756 |
CAMK1G |
0.773 | -0.047 | -3 | 0.774 |
IRAK4 |
0.773 | -0.119 | 1 | 0.185 |
MLK4 |
0.773 | -0.135 | 2 | 0.708 |
SNRK |
0.772 | -0.140 | 2 | 0.692 |
TLK1 |
0.772 | -0.106 | -2 | 0.845 |
PKACA |
0.771 | 0.030 | -2 | 0.688 |
FAM20C |
0.771 | -0.059 | 2 | 0.537 |
PAK5 |
0.771 | -0.010 | -2 | 0.686 |
BMPR1A |
0.771 | -0.040 | 1 | 0.138 |
PKCI |
0.771 | -0.021 | 2 | 0.735 |
MARK1 |
0.770 | -0.064 | 4 | 0.798 |
MEKK1 |
0.770 | -0.159 | 1 | 0.209 |
SSTK |
0.770 | -0.041 | 4 | 0.802 |
MEK5 |
0.770 | -0.160 | 2 | 0.821 |
MST3 |
0.770 | -0.066 | 2 | 0.823 |
MEKK2 |
0.769 | -0.122 | 2 | 0.803 |
TAO3 |
0.769 | -0.051 | 1 | 0.224 |
NEK5 |
0.769 | -0.141 | 1 | 0.199 |
ZAK |
0.769 | -0.162 | 1 | 0.181 |
GSK3B |
0.769 | 0.045 | 4 | 0.446 |
SMMLCK |
0.768 | -0.016 | -3 | 0.836 |
DCAMKL2 |
0.768 | -0.058 | -3 | 0.811 |
PLK3 |
0.768 | -0.140 | 2 | 0.734 |
DRAK1 |
0.766 | -0.162 | 1 | 0.150 |
BUB1 |
0.766 | 0.039 | -5 | 0.766 |
PAK4 |
0.765 | -0.006 | -2 | 0.696 |
BRAF |
0.765 | -0.150 | -4 | 0.834 |
AKT3 |
0.765 | 0.041 | -3 | 0.639 |
PKCE |
0.765 | 0.001 | 2 | 0.697 |
PKN1 |
0.765 | -0.027 | -3 | 0.747 |
SGK1 |
0.765 | 0.062 | -3 | 0.623 |
LKB1 |
0.764 | -0.047 | -3 | 0.861 |
MEKK3 |
0.764 | -0.194 | 1 | 0.197 |
GAK |
0.763 | -0.037 | 1 | 0.244 |
HGK |
0.763 | -0.055 | 3 | 0.917 |
TAO2 |
0.763 | -0.063 | 2 | 0.832 |
TNIK |
0.762 | -0.033 | 3 | 0.917 |
PDK1 |
0.762 | -0.074 | 1 | 0.234 |
MRCKA |
0.761 | 0.025 | -3 | 0.766 |
GRK2 |
0.761 | -0.117 | -2 | 0.696 |
SBK |
0.761 | 0.117 | -3 | 0.586 |
LOK |
0.761 | -0.053 | -2 | 0.772 |
NEK8 |
0.760 | -0.156 | 2 | 0.812 |
NEK11 |
0.760 | -0.149 | 1 | 0.218 |
PBK |
0.760 | -0.013 | 1 | 0.228 |
MRCKB |
0.760 | 0.027 | -3 | 0.747 |
CAMK1D |
0.760 | -0.034 | -3 | 0.696 |
MEKK6 |
0.759 | -0.100 | 1 | 0.201 |
NEK4 |
0.759 | -0.145 | 1 | 0.192 |
GCK |
0.759 | -0.080 | 1 | 0.207 |
MINK |
0.758 | -0.104 | 1 | 0.187 |
MAP3K15 |
0.757 | -0.111 | 1 | 0.196 |
PASK |
0.757 | -0.079 | -3 | 0.853 |
KHS1 |
0.757 | -0.039 | 1 | 0.209 |
DAPK3 |
0.757 | -0.018 | -3 | 0.800 |
ROCK2 |
0.756 | 0.017 | -3 | 0.794 |
CAMKK2 |
0.756 | -0.136 | -2 | 0.745 |
TTBK1 |
0.756 | -0.174 | 2 | 0.610 |
LRRK2 |
0.756 | -0.034 | 2 | 0.834 |
CAMKK1 |
0.756 | -0.193 | -2 | 0.742 |
HPK1 |
0.756 | -0.074 | 1 | 0.211 |
MST2 |
0.755 | -0.132 | 1 | 0.192 |
CHK2 |
0.755 | -0.014 | -3 | 0.647 |
NEK1 |
0.755 | -0.132 | 1 | 0.183 |
KHS2 |
0.755 | -0.018 | 1 | 0.220 |
HASPIN |
0.754 | 0.003 | -1 | 0.662 |
EEF2K |
0.754 | -0.087 | 3 | 0.868 |
PKG1 |
0.753 | 0.001 | -2 | 0.658 |
CRIK |
0.753 | 0.061 | -3 | 0.721 |
IRAK1 |
0.752 | -0.227 | -1 | 0.759 |
BIKE |
0.752 | -0.006 | 1 | 0.232 |
SLK |
0.752 | -0.067 | -2 | 0.707 |
CAMK1A |
0.752 | -0.017 | -3 | 0.663 |
CK1E |
0.751 | -0.069 | -3 | 0.480 |
NEK3 |
0.751 | -0.093 | 1 | 0.209 |
YSK1 |
0.751 | -0.101 | 2 | 0.809 |
VRK1 |
0.751 | -0.153 | 2 | 0.838 |
CK2A2 |
0.749 | -0.075 | 1 | 0.131 |
DMPK1 |
0.749 | 0.045 | -3 | 0.758 |
AAK1 |
0.749 | 0.028 | 1 | 0.234 |
MST1 |
0.749 | -0.134 | 1 | 0.186 |
DAPK1 |
0.749 | -0.026 | -3 | 0.782 |
TAK1 |
0.748 | -0.189 | 1 | 0.183 |
ROCK1 |
0.747 | 0.016 | -3 | 0.763 |
CK1G1 |
0.746 | -0.098 | -3 | 0.474 |
MEK2 |
0.746 | -0.177 | 2 | 0.816 |
RIPK2 |
0.745 | -0.206 | 1 | 0.168 |
CK1D |
0.745 | -0.042 | -3 | 0.427 |
PDHK3_TYR |
0.745 | 0.103 | 4 | 0.855 |
LIMK2_TYR |
0.743 | 0.134 | -3 | 0.915 |
GRK3 |
0.742 | -0.126 | -2 | 0.653 |
STK33 |
0.740 | -0.152 | 2 | 0.590 |
MYO3B |
0.740 | -0.065 | 2 | 0.821 |
CK2A1 |
0.739 | -0.087 | 1 | 0.122 |
OSR1 |
0.739 | -0.079 | 2 | 0.801 |
TESK1_TYR |
0.739 | 0.026 | 3 | 0.927 |
CK1A2 |
0.739 | -0.068 | -3 | 0.424 |
PKMYT1_TYR |
0.739 | 0.118 | 3 | 0.889 |
TTK |
0.738 | -0.070 | -2 | 0.855 |
TAO1 |
0.738 | -0.085 | 1 | 0.199 |
MYO3A |
0.736 | -0.084 | 1 | 0.215 |
PDHK4_TYR |
0.735 | 0.019 | 2 | 0.861 |
PLK2 |
0.734 | -0.115 | -3 | 0.773 |
ASK1 |
0.734 | -0.141 | 1 | 0.193 |
MAP2K4_TYR |
0.733 | -0.020 | -1 | 0.867 |
MAP2K7_TYR |
0.732 | -0.091 | 2 | 0.843 |
RET |
0.731 | -0.110 | 1 | 0.220 |
MAP2K6_TYR |
0.731 | -0.019 | -1 | 0.863 |
PINK1_TYR |
0.730 | -0.121 | 1 | 0.244 |
LIMK1_TYR |
0.730 | 0.003 | 2 | 0.845 |
NEK10_TYR |
0.729 | -0.066 | 1 | 0.202 |
BMPR2_TYR |
0.728 | -0.025 | -1 | 0.841 |
MST1R |
0.727 | -0.092 | 3 | 0.853 |
PDHK1_TYR |
0.726 | -0.094 | -1 | 0.877 |
JAK2 |
0.726 | -0.117 | 1 | 0.227 |
TYK2 |
0.726 | -0.184 | 1 | 0.209 |
ALPHAK3 |
0.725 | -0.117 | -1 | 0.753 |
ROS1 |
0.723 | -0.125 | 3 | 0.824 |
CSF1R |
0.723 | -0.101 | 3 | 0.831 |
TYRO3 |
0.722 | -0.144 | 3 | 0.856 |
TNNI3K_TYR |
0.721 | -0.039 | 1 | 0.233 |
STLK3 |
0.721 | -0.173 | 1 | 0.171 |
ABL2 |
0.720 | -0.094 | -1 | 0.827 |
JAK3 |
0.720 | -0.121 | 1 | 0.204 |
EPHA6 |
0.720 | -0.114 | -1 | 0.843 |
TNK1 |
0.720 | -0.063 | 3 | 0.835 |
JAK1 |
0.720 | -0.096 | 1 | 0.199 |
DDR1 |
0.718 | -0.135 | 4 | 0.784 |
ABL1 |
0.718 | -0.095 | -1 | 0.826 |
YES1 |
0.717 | -0.103 | -1 | 0.859 |
EPHB4 |
0.717 | -0.145 | -1 | 0.830 |
TXK |
0.716 | -0.092 | 1 | 0.149 |
FGFR1 |
0.716 | -0.045 | 3 | 0.797 |
FGFR2 |
0.715 | -0.062 | 3 | 0.816 |
TEK |
0.715 | -0.017 | 3 | 0.779 |
LCK |
0.713 | -0.099 | -1 | 0.833 |
PDGFRB |
0.713 | -0.183 | 3 | 0.846 |
FLT3 |
0.712 | -0.158 | 3 | 0.846 |
FGR |
0.712 | -0.180 | 1 | 0.172 |
ITK |
0.712 | -0.135 | -1 | 0.809 |
TNK2 |
0.711 | -0.136 | 3 | 0.781 |
INSRR |
0.711 | -0.153 | 3 | 0.788 |
KDR |
0.711 | -0.104 | 3 | 0.777 |
HCK |
0.711 | -0.153 | -1 | 0.835 |
BLK |
0.710 | -0.093 | -1 | 0.837 |
FER |
0.709 | -0.205 | 1 | 0.180 |
KIT |
0.709 | -0.148 | 3 | 0.828 |
YANK3 |
0.709 | -0.096 | 2 | 0.369 |
PDGFRA |
0.708 | -0.196 | 3 | 0.846 |
EPHB1 |
0.707 | -0.189 | 1 | 0.159 |
AXL |
0.706 | -0.175 | 3 | 0.811 |
EPHA4 |
0.705 | -0.128 | 2 | 0.724 |
WEE1_TYR |
0.705 | -0.094 | -1 | 0.739 |
DDR2 |
0.705 | -0.057 | 3 | 0.754 |
SRMS |
0.705 | -0.200 | 1 | 0.154 |
TEC |
0.705 | -0.134 | -1 | 0.762 |
EPHB3 |
0.704 | -0.187 | -1 | 0.819 |
MERTK |
0.703 | -0.166 | 3 | 0.811 |
EPHB2 |
0.703 | -0.171 | -1 | 0.813 |
MET |
0.702 | -0.139 | 3 | 0.828 |
BTK |
0.702 | -0.202 | -1 | 0.792 |
FGFR3 |
0.702 | -0.088 | 3 | 0.784 |
BMX |
0.701 | -0.134 | -1 | 0.717 |
ALK |
0.701 | -0.170 | 3 | 0.758 |
FRK |
0.699 | -0.153 | -1 | 0.850 |
CK1A |
0.699 | -0.093 | -3 | 0.327 |
PTK6 |
0.698 | -0.204 | -1 | 0.746 |
FLT1 |
0.697 | -0.158 | -1 | 0.818 |
FYN |
0.697 | -0.116 | -1 | 0.796 |
LTK |
0.697 | -0.183 | 3 | 0.766 |
FLT4 |
0.697 | -0.165 | 3 | 0.764 |
ERBB2 |
0.696 | -0.186 | 1 | 0.178 |
EPHA1 |
0.696 | -0.174 | 3 | 0.802 |
NTRK2 |
0.696 | -0.215 | 3 | 0.790 |
PTK2B |
0.696 | -0.105 | -1 | 0.798 |
INSR |
0.695 | -0.176 | 3 | 0.770 |
EPHA7 |
0.694 | -0.171 | 2 | 0.732 |
NTRK1 |
0.694 | -0.240 | -1 | 0.811 |
MUSK |
0.693 | -0.132 | 1 | 0.136 |
EGFR |
0.693 | -0.128 | 1 | 0.142 |
LYN |
0.691 | -0.164 | 3 | 0.747 |
EPHA3 |
0.690 | -0.184 | 2 | 0.706 |
NTRK3 |
0.689 | -0.190 | -1 | 0.758 |
SRC |
0.689 | -0.143 | -1 | 0.808 |
MATK |
0.688 | -0.134 | -1 | 0.742 |
FGFR4 |
0.685 | -0.140 | -1 | 0.766 |
EPHA5 |
0.685 | -0.181 | 2 | 0.709 |
EPHA8 |
0.684 | -0.164 | -1 | 0.789 |
CSK |
0.683 | -0.190 | 2 | 0.743 |
CK1G3 |
0.681 | -0.091 | -3 | 0.274 |
SYK |
0.678 | -0.123 | -1 | 0.738 |
PTK2 |
0.677 | -0.107 | -1 | 0.751 |
IGF1R |
0.677 | -0.173 | 3 | 0.709 |
ERBB4 |
0.675 | -0.128 | 1 | 0.142 |
EPHA2 |
0.675 | -0.170 | -1 | 0.756 |
YANK2 |
0.671 | -0.123 | 2 | 0.378 |
ZAP70 |
0.667 | -0.088 | -1 | 0.653 |
FES |
0.660 | -0.180 | -1 | 0.699 |
CK1G2 |
0.655 | -0.103 | -3 | 0.378 |