Motif 629 (n=161)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | T1638 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14715 | RGPD8 | T1637 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14980 | XPO1 | S1031 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15027 | SEC16A | S561 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15372 | EIF3H | S183 | ochoa|psp | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43663 | PRC1 | S267 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60237 | PPP1R12B | S412 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O94992 | HEXIM1 | S158 | psp | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| P02545 | LMNA | S431 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05060 | CHGB | S367 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05181 | CYP2E1 | S256 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P06753 | TPM3 | S207 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07197 | NEFM | S620 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07197 | NEFM | S633 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07197 | NEFM | S672 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07814 | EPRS1 | S750 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07900 | HSP90AA1 | S595 | ochoa|psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07951 | TPM2 | S206 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P0DJD0 | RGPD1 | T1622 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1630 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10645 | CHGA | S270 | psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11532 | DMD | S3666 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P12882 | MYH1 | S1132 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1491 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1493 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P17676 | CEBPB | S288 | psp | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P22466 | GAL | S76 | ochoa | Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)] | Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. {ECO:0000269|PubMed:1370155, ECO:0000269|PubMed:1722333, ECO:0000269|PubMed:25691535}. |
| P25705 | ATP5F1A | S53 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P28290 | ITPRID2 | S794 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28290 | ITPRID2 | S944 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P35579 | MYH9 | S1017 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P38398 | BRCA1 | S891 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38398 | BRCA1 | S1271 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P43121 | MCAM | S603 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P46013 | MKI67 | S1118 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1142 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1264 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1506 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1628 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1750 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1994 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2355 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2575 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2599 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2719 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2837 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S1527 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46940 | IQGAP1 | S1441 | ochoa|psp | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48681 | NES | S638 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S891 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S299 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P50548 | ERF | S24 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P51587 | BRCA2 | S445 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P62851 | RPS25 | S74 | ochoa | Small ribosomal subunit protein eS25 (40S ribosomal protein S25) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P67936 | TPM4 | S170 | ochoa | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}. |
| P78417 | GSTO1 | S129 | ochoa | Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) | Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}. |
| P78559 | MAP1A | S322 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S570 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98170 | XIAP | S430 | psp | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238, PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:9230442). Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640). Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:29452636, PubMed:30026309). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967). {ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11447297, ECO:0000269|PubMed:12121969, ECO:0000269|PubMed:12620238, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17560374, ECO:0000269|PubMed:17967870, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:19667203, ECO:0000269|PubMed:20154138, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:22103349, ECO:0000269|PubMed:22304967, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:29020630, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:9230442, ECO:0000303|PubMed:22095281}. |
| P98175 | RBM10 | S723 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q03188 | CENPC | S447 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05682 | CALD1 | S134 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07866 | KLC1 | S524 | ochoa | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q0JRZ9 | FCHO2 | S304 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q0VAQ4 | SMAGP | S77 | ochoa | Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein) | May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. {ECO:0000269|PubMed:15986429}. |
| Q0ZGT2 | NEXN | S218 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12986 | NFX1 | S346 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13042 | CDC16 | S560 | ochoa|psp | Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q13283 | G3BP1 | S373 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13415 | ORC1 | S182 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q14254 | FLOT2 | S385 | ochoa | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Q14562 | DHX8 | S385 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14676 | MDC1 | S882 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15233 | NONO | S149 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15311 | RALBP1 | S461 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15785 | TOMM34 | S186 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16520 | BATF | S43 | psp | Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2) | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). {ECO:0000250}. |
| Q2NKX8 | ERCC6L | S872 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q32MZ4 | LRRFIP1 | S536 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q53EZ4 | CEP55 | S215 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q56NI9 | ESCO2 | S29 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q58FF8 | HSP90AB2P | S305 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5SW79 | CEP170 | S739 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T8P6 | RBM26 | S92 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5TAP6 | UTP14C | S536 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
| Q5TB30 | DEPDC1 | S341 | ochoa | DEP domain-containing protein 1A | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
| Q5UIP0 | RIF1 | S1431 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZ89 | DENND4C | S908 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5W0B1 | OBI1 | S568 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q641Q2 | WASHC2A | S529 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6IC98 | GRAMD4 | S33 | ochoa | GRAM domain-containing protein 4 (Death-inducing protein) | Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8CB44, ECO:0000269|PubMed:15565177}. |
| Q6P0N0 | MIS18BP1 | S761 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P4F7 | ARHGAP11A | S620 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6ZSZ6 | TSHZ1 | S523 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q7L9L4 | MOB1B | S38 | ochoa | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7Z3J3 | RGPD4 | T1638 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5K2 | WAPL | S498 | psp | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z7A1 | CNTRL | S2223 | ochoa | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}. |
| Q86XZ4 | SPATS2 | S208 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IVF2 | AHNAK2 | S5712 | ochoa | Protein AHNAK2 | None |
| Q8IWJ2 | GCC2 | S935 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8N157 | AHI1 | S232 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N573 | OXR1 | S294 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5A5 | ZGPAT | S53 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8NFQ8 | TOR1AIP2 | S22 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NHM5 | KDM2B | S746 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TEQ6 | GEMIN5 | S765 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WWI1 | LMO7 | S706 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWN8 | ARAP3 | S1380 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q92598 | HSPH1 | S809 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92828 | CORO2A | S443 | ochoa | Coronin-2A (IR10) (WD repeat-containing protein 2) | None |
| Q92845 | KIFAP3 | S60 | ochoa | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). {ECO:0000250}. |
| Q96DN5 | TBC1D31 | S902 | ochoa | TBC1 domain family member 31 (WD repeat-containing protein 67) | Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}. |
| Q96FF9 | CDCA5 | S107 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96RS6 | NUDCD1 | S373 | ochoa | NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) | None |
| Q99549 | MPHOSPH8 | S192 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99590 | SCAF11 | S565 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S587 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S687 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99666 | RGPD5 | T1637 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BT25 | HAUS8 | S133 | ochoa|psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BUR4 | WRAP53 | S99 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BW19 | KIFC1 | S31 | ochoa|psp | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}. |
| Q9BYW2 | SETD2 | S1891 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0C2 | TNKS1BP1 | S1248 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H582 | ZNF644 | S1074 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6T3 | RPAP3 | S87 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H8S9 | MOB1A | S38 | ochoa | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9HAU0 | PLEKHA5 | S809 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HBX9 | RXFP1 | S304 | ochoa | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Q9NUL3 | STAU2 | S395 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NVN8 | GNL3L | S42 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NVN8 | GNL3L | S87 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NYF8 | BCLAF1 | S181 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P2R6 | RERE | S53 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UEY8 | ADD3 | S618 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHR4 | BAIAP2L1 | Y114 | psp | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UK61 | TASOR | S818 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKX2 | MYH2 | S1134 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULU4 | ZMYND8 | S630 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9Y2D8 | SSX2IP | S452 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2F5 | ICE1 | S693 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y4E5 | ZNF451 | S825 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Q9Y597 | KCTD3 | S736 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5T5 | USP16 | S598 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y617 | PSAT1 | S46 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y623 | MYH4 | S1132 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P13073 | COX4I1 | S72 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P46940 | IQGAP1 | S730 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| Q8TD16 | BICD2 | S658 | Sugiyama | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q13043 | STK4 | S43 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13188 | STK3 | S40 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q13224 | GRIN2B | S383 | iPTMNet | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| P49641 | MAN2A2 | S662 | Sugiyama | Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. |
| Q6XUX3 | DSTYK | S603 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| P46013 | MKI67 | S2116 | Sugiyama | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| Q13617 | CUL2 | S230 | Sugiyama | Cullin-2 (CUL-2) | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:38326650). CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme (PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655, PubMed:9122164, PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346, PubMed:38326650). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:10973499, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:9122164, PubMed:38326650). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:10973499, PubMed:9122164). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:Q9D4H8, ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:9122164}. |
| Q9P0L2 | MARK1 | S435 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9NQC3 | RTN4 | S778 | Sugiyama | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q14524 | SCN5A | S1885 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14524 | SCN5A | S471 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000003 | 5.515 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000027 | 4.572 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000027 | 4.572 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000053 | 4.275 |
| R-HSA-2028269 | Signaling by Hippo | 0.000074 | 4.133 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000073 | 4.137 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000228 | 3.642 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.000309 | 3.510 |
| R-HSA-68877 | Mitotic Prometaphase | 0.001269 | 2.897 |
| R-HSA-68886 | M Phase | 0.002245 | 2.649 |
| R-HSA-68882 | Mitotic Anaphase | 0.002461 | 2.609 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.002525 | 2.598 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.002563 | 2.591 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.003240 | 2.489 |
| R-HSA-69275 | G2/M Transition | 0.004364 | 2.360 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.004597 | 2.338 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005392 | 2.268 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.006931 | 2.159 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.006931 | 2.159 |
| R-HSA-397014 | Muscle contraction | 0.008356 | 2.078 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.009553 | 2.020 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.011050 | 1.957 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.011100 | 1.955 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.010204 | 1.991 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.019434 | 1.711 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.019434 | 1.711 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.019434 | 1.711 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.019434 | 1.711 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.019434 | 1.711 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.019434 | 1.711 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.019434 | 1.711 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.019434 | 1.711 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.019434 | 1.711 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.016922 | 1.772 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.015287 | 1.816 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.021839 | 1.661 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.021839 | 1.661 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.013294 | 1.876 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.021839 | 1.661 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.018197 | 1.740 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.021688 | 1.664 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.020532 | 1.688 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.023629 | 1.627 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.025477 | 1.594 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.025477 | 1.594 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.025477 | 1.594 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.025477 | 1.594 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.024467 | 1.611 |
| R-HSA-69242 | S Phase | 0.024598 | 1.609 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.038492 | 1.415 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.038492 | 1.415 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.038492 | 1.415 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.038492 | 1.415 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.038492 | 1.415 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.038492 | 1.415 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.038492 | 1.415 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.038492 | 1.415 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.038492 | 1.415 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.038492 | 1.415 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.038492 | 1.415 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.037716 | 1.423 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.033386 | 1.476 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.033386 | 1.476 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.037016 | 1.432 |
| R-HSA-983189 | Kinesins | 0.029951 | 1.524 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.029009 | 1.537 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.032219 | 1.492 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.029343 | 1.533 |
| R-HSA-373755 | Semaphorin interactions | 0.033386 | 1.476 |
| R-HSA-5218859 | Regulated Necrosis | 0.039544 | 1.403 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.039936 | 1.399 |
| R-HSA-73886 | Chromosome Maintenance | 0.044863 | 1.348 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.046238 | 1.335 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.046882 | 1.329 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.066391 | 1.178 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.066391 | 1.178 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.061960 | 1.208 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.061960 | 1.208 |
| R-HSA-380287 | Centrosome maturation | 0.049062 | 1.309 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.066046 | 1.180 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.066046 | 1.180 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.071088 | 1.148 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.061960 | 1.208 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.064615 | 1.190 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.072800 | 1.138 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.059592 | 1.225 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.059345 | 1.227 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.066391 | 1.178 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.054233 | 1.266 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.056769 | 1.246 |
| R-HSA-3371511 | HSF1 activation | 0.067307 | 1.172 |
| R-HSA-1500620 | Meiosis | 0.064403 | 1.191 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.070035 | 1.155 |
| R-HSA-5617833 | Cilium Assembly | 0.056133 | 1.251 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.058927 | 1.230 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.056769 | 1.246 |
| R-HSA-5357801 | Programmed Cell Death | 0.071953 | 1.143 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.067307 | 1.172 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.054233 | 1.266 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.075511 | 1.122 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.075511 | 1.122 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.075511 | 1.122 |
| R-HSA-444821 | Relaxin receptors | 0.075511 | 1.122 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.075599 | 1.121 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.075599 | 1.121 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.084542 | 1.073 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.093486 | 1.029 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.178283 | 0.749 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.178283 | 0.749 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.194271 | 0.712 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.194271 | 0.712 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.209951 | 0.678 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.217676 | 0.662 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.225327 | 0.647 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.225327 | 0.647 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.225327 | 0.647 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.096092 | 1.017 |
| R-HSA-774815 | Nucleosome assembly | 0.096092 | 1.017 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.232903 | 0.633 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.232903 | 0.633 |
| R-HSA-211999 | CYP2E1 reactions | 0.255193 | 0.593 |
| R-HSA-72649 | Translation initiation complex formation | 0.124402 | 0.905 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.130941 | 0.883 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.276839 | 0.558 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.161251 | 0.792 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.279020 | 0.554 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.269694 | 0.569 |
| R-HSA-3371568 | Attenuation phase | 0.078432 | 1.106 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.297859 | 0.526 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.140894 | 0.851 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.217617 | 0.662 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.283914 | 0.547 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.127808 | 0.893 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.194271 | 0.712 |
| R-HSA-1221632 | Meiotic synapsis | 0.121163 | 0.917 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.168152 | 0.774 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.202149 | 0.694 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.114751 | 0.940 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.104715 | 0.980 |
| R-HSA-5693538 | Homology Directed Repair | 0.141106 | 0.850 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.168152 | 0.774 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.088860 | 1.051 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.232001 | 0.635 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.081298 | 1.090 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.102343 | 0.990 |
| R-HSA-192905 | vRNP Assembly | 0.128401 | 0.891 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.136918 | 0.864 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.145354 | 0.838 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.186316 | 0.730 |
| R-HSA-8949613 | Cristae formation | 0.276839 | 0.558 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.283914 | 0.547 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.189138 | 0.723 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.202149 | 0.694 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.268159 | 0.572 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.186316 | 0.730 |
| R-HSA-9620244 | Long-term potentiation | 0.262479 | 0.581 |
| R-HSA-3371556 | Cellular response to heat stress | 0.147923 | 0.830 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.304308 | 0.517 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.297859 | 0.526 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.247835 | 0.606 |
| R-HSA-912446 | Meiotic recombination | 0.114751 | 0.940 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.271780 | 0.566 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.111114 | 0.954 |
| R-HSA-9711097 | Cellular response to starvation | 0.249487 | 0.603 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.186316 | 0.730 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.225327 | 0.647 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.099137 | 1.004 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.124402 | 0.905 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.137558 | 0.862 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.297859 | 0.526 |
| R-HSA-157579 | Telomere Maintenance | 0.286255 | 0.543 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.255193 | 0.593 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.102343 | 0.990 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.111114 | 0.954 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.202149 | 0.694 |
| R-HSA-9675135 | Diseases of DNA repair | 0.099137 | 1.004 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.282638 | 0.549 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.084197 | 1.075 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.093486 | 1.029 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.119799 | 0.922 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.136918 | 0.864 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.209951 | 0.678 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.232903 | 0.633 |
| R-HSA-429947 | Deadenylation of mRNA | 0.255193 | 0.593 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.262479 | 0.581 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.276839 | 0.558 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.276839 | 0.558 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.192671 | 0.715 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.232001 | 0.635 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.290921 | 0.536 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.247835 | 0.606 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.134240 | 0.872 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.304308 | 0.517 |
| R-HSA-69481 | G2/M Checkpoints | 0.164230 | 0.785 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.093486 | 1.029 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.111114 | 0.954 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.117094 | 0.931 |
| R-HSA-2559583 | Cellular Senescence | 0.133266 | 0.875 |
| R-HSA-3928664 | Ephrin signaling | 0.202149 | 0.694 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.089086 | 1.050 |
| R-HSA-1474165 | Reproduction | 0.173780 | 0.760 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.119311 | 0.923 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.119799 | 0.922 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.269694 | 0.569 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.081298 | 1.090 |
| R-HSA-2262752 | Cellular responses to stress | 0.142840 | 0.845 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.217676 | 0.662 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 0.240406 | 0.619 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.079864 | 1.098 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.283914 | 0.547 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.297859 | 0.526 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.189138 | 0.723 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.255073 | 0.593 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.153707 | 0.813 |
| R-HSA-977347 | Serine metabolism | 0.232903 | 0.633 |
| R-HSA-70635 | Urea cycle | 0.269694 | 0.569 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.297859 | 0.526 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.203304 | 0.692 |
| R-HSA-199991 | Membrane Trafficking | 0.123614 | 0.908 |
| R-HSA-3214842 | HDMs demethylate histones | 0.262479 | 0.581 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.297062 | 0.527 |
| R-HSA-109581 | Apoptosis | 0.259973 | 0.585 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.128401 | 0.891 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.225327 | 0.647 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.116070 | 0.935 |
| R-HSA-111458 | Formation of apoptosome | 0.119799 | 0.922 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.192671 | 0.715 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.247835 | 0.606 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.182100 | 0.740 |
| R-HSA-373753 | Nephrin family interactions | 0.217676 | 0.662 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.262479 | 0.581 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.232001 | 0.635 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.240406 | 0.619 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.240406 | 0.619 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.294398 | 0.531 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.262479 | 0.581 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.227338 | 0.643 |
| R-HSA-75153 | Apoptotic execution phase | 0.099137 | 1.004 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.276839 | 0.558 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.300703 | 0.522 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.255193 | 0.593 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.255193 | 0.593 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.154629 | 0.811 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.276839 | 0.558 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.214034 | 0.670 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.196783 | 0.706 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.105308 | 0.978 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.161251 | 0.792 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.257297 | 0.590 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.276839 | 0.558 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.107097 | 0.970 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.239216 | 0.621 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.198301 | 0.703 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.260917 | 0.583 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.199762 | 0.699 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.242828 | 0.615 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.304730 | 0.516 |
| R-HSA-168255 | Influenza Infection | 0.307731 | 0.512 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.318273 | 0.497 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.318273 | 0.497 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.318273 | 0.497 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.318273 | 0.497 |
| R-HSA-9930044 | Nuclear RNA decay | 0.318273 | 0.497 |
| R-HSA-422475 | Axon guidance | 0.321099 | 0.493 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.324945 | 0.488 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.324945 | 0.488 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.324945 | 0.488 |
| R-HSA-69239 | Synthesis of DNA | 0.325860 | 0.487 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.329436 | 0.482 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.329436 | 0.482 |
| R-HSA-203615 | eNOS activation | 0.331553 | 0.479 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.331553 | 0.479 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.331553 | 0.479 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.333008 | 0.478 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.338096 | 0.471 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.338096 | 0.471 |
| R-HSA-381042 | PERK regulates gene expression | 0.338096 | 0.471 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.350993 | 0.455 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.357347 | 0.447 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.357347 | 0.447 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.361368 | 0.442 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.364883 | 0.438 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.364883 | 0.438 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.369871 | 0.432 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.369871 | 0.432 |
| R-HSA-9646399 | Aggrephagy | 0.369871 | 0.432 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 0.369871 | 0.432 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.376042 | 0.425 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.376042 | 0.425 |
| R-HSA-68875 | Mitotic Prophase | 0.378870 | 0.422 |
| R-HSA-9675108 | Nervous system development | 0.380016 | 0.420 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.382152 | 0.418 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.382152 | 0.418 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.382152 | 0.418 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.382152 | 0.418 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.388203 | 0.411 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.388203 | 0.411 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.389276 | 0.410 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.394195 | 0.404 |
| R-HSA-194138 | Signaling by VEGF | 0.399606 | 0.398 |
| R-HSA-69206 | G1/S Transition | 0.399606 | 0.398 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.400129 | 0.398 |
| R-HSA-156581 | Methylation | 0.400129 | 0.398 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.406005 | 0.391 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.411824 | 0.385 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.411824 | 0.385 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.411824 | 0.385 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.411824 | 0.385 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.411824 | 0.385 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.411824 | 0.385 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.411824 | 0.385 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.417587 | 0.379 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.417587 | 0.379 |
| R-HSA-8951664 | Neddylation | 0.421750 | 0.375 |
| R-HSA-5620924 | Intraflagellar transport | 0.423293 | 0.373 |
| R-HSA-9843745 | Adipogenesis | 0.423385 | 0.373 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.440080 | 0.356 |
| R-HSA-9864848 | Complex IV assembly | 0.440080 | 0.356 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.445567 | 0.351 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.445567 | 0.351 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.445567 | 0.351 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.445567 | 0.351 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.445567 | 0.351 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.446676 | 0.350 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.449960 | 0.347 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.451001 | 0.346 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.451001 | 0.346 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.451001 | 0.346 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.456382 | 0.341 |
| R-HSA-9664407 | Parasite infection | 0.456497 | 0.341 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.456497 | 0.341 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.456497 | 0.341 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.461710 | 0.336 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.461710 | 0.336 |
| R-HSA-9753281 | Paracetamol ADME | 0.461710 | 0.336 |
| R-HSA-8953854 | Metabolism of RNA | 0.464452 | 0.333 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.466218 | 0.331 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.466987 | 0.331 |
| R-HSA-75893 | TNF signaling | 0.466987 | 0.331 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.466987 | 0.331 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.466987 | 0.331 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.472212 | 0.326 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.479020 | 0.320 |
| R-HSA-191859 | snRNP Assembly | 0.482510 | 0.316 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.482510 | 0.316 |
| R-HSA-180786 | Extension of Telomeres | 0.482510 | 0.316 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.482510 | 0.316 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.486455 | 0.313 |
| R-HSA-379724 | tRNA Aminoacylation | 0.487584 | 0.312 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.487584 | 0.312 |
| R-HSA-156590 | Glutathione conjugation | 0.487584 | 0.312 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.487584 | 0.312 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.490669 | 0.309 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.491635 | 0.308 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.491635 | 0.308 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.497583 | 0.303 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.497583 | 0.303 |
| R-HSA-9707616 | Heme signaling | 0.497583 | 0.303 |
| R-HSA-1268020 | Mitochondrial protein import | 0.497583 | 0.303 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.497583 | 0.303 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.497870 | 0.303 |
| R-HSA-69306 | DNA Replication | 0.500970 | 0.300 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.502510 | 0.299 |
| R-HSA-73887 | Death Receptor Signaling | 0.504057 | 0.298 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.507132 | 0.295 |
| R-HSA-211981 | Xenobiotics | 0.507389 | 0.295 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.512221 | 0.291 |
| R-HSA-73894 | DNA Repair | 0.513585 | 0.289 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.517005 | 0.287 |
| R-HSA-162582 | Signal Transduction | 0.525305 | 0.280 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.526434 | 0.279 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.526434 | 0.279 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.534248 | 0.272 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.535681 | 0.271 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.535681 | 0.271 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.535681 | 0.271 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.540236 | 0.267 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.540236 | 0.267 |
| R-HSA-8978934 | Metabolism of cofactors | 0.540236 | 0.267 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.544748 | 0.264 |
| R-HSA-9749641 | Aspirin ADME | 0.549215 | 0.260 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.554628 | 0.256 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.558019 | 0.253 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.570578 | 0.244 |
| R-HSA-9659379 | Sensory processing of sound | 0.575118 | 0.240 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.583420 | 0.234 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.590790 | 0.229 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.591560 | 0.228 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.598822 | 0.223 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.603475 | 0.219 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.604111 | 0.219 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.607369 | 0.217 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.607369 | 0.217 |
| R-HSA-449147 | Signaling by Interleukins | 0.611183 | 0.214 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.611225 | 0.214 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.611225 | 0.214 |
| R-HSA-156902 | Peptide chain elongation | 0.615044 | 0.211 |
| R-HSA-9663891 | Selective autophagy | 0.615044 | 0.211 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.615044 | 0.211 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.619662 | 0.208 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.626278 | 0.203 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.629950 | 0.201 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.633586 | 0.198 |
| R-HSA-391251 | Protein folding | 0.633586 | 0.198 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.639666 | 0.194 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.642108 | 0.192 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.644282 | 0.191 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.644282 | 0.191 |
| R-HSA-72766 | Translation | 0.646699 | 0.189 |
| R-HSA-72172 | mRNA Splicing | 0.646953 | 0.189 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.647778 | 0.189 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.647778 | 0.189 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.654668 | 0.184 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.658062 | 0.182 |
| R-HSA-422356 | Regulation of insulin secretion | 0.658062 | 0.182 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.661424 | 0.180 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.668048 | 0.175 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.671312 | 0.173 |
| R-HSA-1483255 | PI Metabolism | 0.671312 | 0.173 |
| R-HSA-192823 | Viral mRNA Translation | 0.674544 | 0.171 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.677744 | 0.169 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.687159 | 0.163 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.690236 | 0.161 |
| R-HSA-211000 | Gene Silencing by RNA | 0.690236 | 0.161 |
| R-HSA-6803157 | Antimicrobial peptides | 0.702246 | 0.154 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.705176 | 0.152 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.705176 | 0.152 |
| R-HSA-72312 | rRNA processing | 0.709450 | 0.149 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.713542 | 0.147 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.713794 | 0.146 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.716611 | 0.145 |
| R-HSA-8939211 | ESR-mediated signaling | 0.719591 | 0.143 |
| R-HSA-373760 | L1CAM interactions | 0.722162 | 0.141 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.724896 | 0.140 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.724896 | 0.140 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.740753 | 0.130 |
| R-HSA-4839726 | Chromatin organization | 0.742727 | 0.129 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.743306 | 0.129 |
| R-HSA-5688426 | Deubiquitination | 0.753675 | 0.123 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.760286 | 0.119 |
| R-HSA-74160 | Gene expression (Transcription) | 0.763345 | 0.117 |
| R-HSA-5576891 | Cardiac conduction | 0.765186 | 0.116 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.776032 | 0.110 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.778734 | 0.109 |
| R-HSA-163685 | Integration of energy metabolism | 0.778734 | 0.109 |
| R-HSA-212436 | Generic Transcription Pathway | 0.780119 | 0.108 |
| R-HSA-6807070 | PTEN Regulation | 0.785213 | 0.105 |
| R-HSA-1632852 | Macroautophagy | 0.789428 | 0.103 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.793554 | 0.100 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.793560 | 0.100 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.795596 | 0.099 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.795596 | 0.099 |
| R-HSA-9658195 | Leishmania infection | 0.796608 | 0.099 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.796608 | 0.099 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.802248 | 0.096 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.803542 | 0.095 |
| R-HSA-166520 | Signaling by NTRKs | 0.805480 | 0.094 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.808428 | 0.092 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.809299 | 0.092 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.811180 | 0.091 |
| R-HSA-9609507 | Protein localization | 0.814888 | 0.089 |
| R-HSA-1483257 | Phospholipid metabolism | 0.816891 | 0.088 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.818269 | 0.087 |
| R-HSA-9679506 | SARS-CoV Infections | 0.819975 | 0.086 |
| R-HSA-9612973 | Autophagy | 0.820315 | 0.086 |
| R-HSA-195721 | Signaling by WNT | 0.820997 | 0.086 |
| R-HSA-162587 | HIV Life Cycle | 0.822089 | 0.085 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.827306 | 0.082 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.827306 | 0.082 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.838895 | 0.076 |
| R-HSA-1500931 | Cell-Cell communication | 0.843949 | 0.074 |
| R-HSA-72306 | tRNA processing | 0.845167 | 0.073 |
| R-HSA-418555 | G alpha (s) signalling events | 0.846696 | 0.072 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.849711 | 0.071 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.849711 | 0.071 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.849711 | 0.071 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.849711 | 0.071 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.849711 | 0.071 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.852135 | 0.069 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.852666 | 0.069 |
| R-HSA-611105 | Respiratory electron transport | 0.856992 | 0.067 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.871429 | 0.060 |
| R-HSA-1643685 | Disease | 0.875973 | 0.058 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.876389 | 0.057 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.880418 | 0.055 |
| R-HSA-1266738 | Developmental Biology | 0.881499 | 0.055 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.888461 | 0.051 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.891875 | 0.050 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.892729 | 0.049 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.899027 | 0.046 |
| R-HSA-9748784 | Drug ADME | 0.904883 | 0.043 |
| R-HSA-418990 | Adherens junctions interactions | 0.904883 | 0.043 |
| R-HSA-162906 | HIV Infection | 0.913040 | 0.040 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.915601 | 0.038 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.916304 | 0.038 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.922844 | 0.035 |
| R-HSA-421270 | Cell-cell junction organization | 0.931549 | 0.031 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.933353 | 0.030 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.947729 | 0.023 |
| R-HSA-446728 | Cell junction organization | 0.947729 | 0.023 |
| R-HSA-6798695 | Neutrophil degranulation | 0.950086 | 0.022 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.950375 | 0.022 |
| R-HSA-112316 | Neuronal System | 0.954464 | 0.020 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.955903 | 0.020 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.961320 | 0.017 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.966687 | 0.015 |
| R-HSA-1474244 | Extracellular matrix organization | 0.969255 | 0.014 |
| R-HSA-211859 | Biological oxidations | 0.971400 | 0.013 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.972468 | 0.012 |
| R-HSA-1280218 | Adaptive Immune System | 0.981454 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.983177 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 0.983829 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.985825 | 0.006 |
| R-HSA-109582 | Hemostasis | 0.986785 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.989519 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.992685 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.992832 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.994626 | 0.002 |
| R-HSA-168256 | Immune System | 0.996050 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.996910 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998445 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998563 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999961 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999973 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.876 | 0.359 | 1 | 0.842 |
COT |
0.874 | 0.236 | 2 | 0.868 |
CDKL1 |
0.856 | 0.133 | -3 | 0.789 |
NLK |
0.856 | 0.150 | 1 | 0.863 |
MTOR |
0.855 | 0.071 | 1 | 0.819 |
RAF1 |
0.854 | 0.103 | 1 | 0.844 |
DSTYK |
0.854 | 0.121 | 2 | 0.885 |
SRPK1 |
0.854 | 0.174 | -3 | 0.741 |
PKCD |
0.853 | 0.214 | 2 | 0.818 |
MST4 |
0.853 | 0.194 | 2 | 0.857 |
CDK1 |
0.853 | 0.269 | 1 | 0.698 |
TBK1 |
0.853 | 0.100 | 1 | 0.782 |
PRPK |
0.852 | -0.068 | -1 | 0.808 |
PIM3 |
0.851 | 0.061 | -3 | 0.835 |
MLK1 |
0.850 | 0.112 | 2 | 0.828 |
CHAK2 |
0.850 | 0.199 | -1 | 0.859 |
CDK5 |
0.850 | 0.252 | 1 | 0.746 |
PKN3 |
0.850 | 0.075 | -3 | 0.814 |
CDC7 |
0.848 | -0.052 | 1 | 0.778 |
CDKL5 |
0.848 | 0.113 | -3 | 0.774 |
MOS |
0.848 | -0.014 | 1 | 0.815 |
SRPK2 |
0.848 | 0.157 | -3 | 0.670 |
IKKE |
0.848 | 0.073 | 1 | 0.787 |
ULK2 |
0.848 | -0.008 | 2 | 0.772 |
KIS |
0.848 | 0.137 | 1 | 0.751 |
IKKB |
0.847 | 0.001 | -2 | 0.782 |
CDK3 |
0.847 | 0.311 | 1 | 0.643 |
WNK1 |
0.846 | 0.082 | -2 | 0.877 |
ICK |
0.846 | 0.147 | -3 | 0.817 |
BMPR2 |
0.846 | -0.044 | -2 | 0.901 |
NIK |
0.846 | 0.075 | -3 | 0.875 |
ERK5 |
0.845 | 0.046 | 1 | 0.812 |
PKN2 |
0.845 | 0.098 | -3 | 0.837 |
PIM1 |
0.845 | 0.101 | -3 | 0.792 |
NEK6 |
0.845 | 0.050 | -2 | 0.861 |
CAMK1B |
0.844 | -0.020 | -3 | 0.856 |
PDHK4 |
0.844 | -0.170 | 1 | 0.852 |
MLK3 |
0.844 | 0.155 | 2 | 0.778 |
CAMK2G |
0.844 | -0.033 | 2 | 0.790 |
ATR |
0.844 | -0.030 | 1 | 0.785 |
NEK7 |
0.843 | 0.022 | -3 | 0.820 |
NUAK2 |
0.843 | 0.028 | -3 | 0.841 |
GCN2 |
0.843 | -0.129 | 2 | 0.770 |
IRE2 |
0.842 | 0.111 | 2 | 0.770 |
CDK2 |
0.842 | 0.259 | 1 | 0.757 |
NDR2 |
0.841 | -0.007 | -3 | 0.835 |
CLK1 |
0.841 | 0.193 | -3 | 0.741 |
TGFBR2 |
0.841 | 0.011 | -2 | 0.812 |
HIPK4 |
0.840 | 0.090 | 1 | 0.830 |
PKCB |
0.840 | 0.153 | 2 | 0.777 |
SRPK3 |
0.840 | 0.126 | -3 | 0.726 |
IKKA |
0.840 | 0.080 | -2 | 0.770 |
IRE1 |
0.840 | 0.066 | 1 | 0.780 |
CDK8 |
0.839 | 0.128 | 1 | 0.720 |
PKCA |
0.838 | 0.150 | 2 | 0.772 |
NDR1 |
0.838 | -0.006 | -3 | 0.827 |
CLK4 |
0.838 | 0.150 | -3 | 0.772 |
PDHK1 |
0.838 | -0.149 | 1 | 0.846 |
ULK1 |
0.838 | -0.041 | -3 | 0.794 |
LATS1 |
0.838 | 0.128 | -3 | 0.834 |
PKCG |
0.838 | 0.132 | 2 | 0.773 |
PKCZ |
0.838 | 0.140 | 2 | 0.786 |
CAMLCK |
0.837 | -0.011 | -2 | 0.868 |
CDK18 |
0.837 | 0.162 | 1 | 0.675 |
AMPKA1 |
0.837 | 0.010 | -3 | 0.846 |
GRK1 |
0.837 | 0.068 | -2 | 0.799 |
MLK4 |
0.837 | 0.112 | 2 | 0.739 |
CLK2 |
0.837 | 0.206 | -3 | 0.759 |
GRK5 |
0.837 | -0.107 | -3 | 0.881 |
SKMLCK |
0.837 | 0.010 | -2 | 0.857 |
FAM20C |
0.836 | 0.141 | 2 | 0.676 |
RIPK3 |
0.836 | -0.073 | 3 | 0.731 |
RSK2 |
0.836 | 0.023 | -3 | 0.756 |
PKR |
0.836 | 0.138 | 1 | 0.826 |
PKCH |
0.836 | 0.124 | 2 | 0.759 |
GRK6 |
0.836 | -0.007 | 1 | 0.790 |
MARK4 |
0.836 | -0.022 | 4 | 0.807 |
NEK9 |
0.835 | -0.039 | 2 | 0.824 |
MLK2 |
0.835 | -0.034 | 2 | 0.815 |
CDK19 |
0.834 | 0.128 | 1 | 0.690 |
WNK3 |
0.834 | -0.093 | 1 | 0.816 |
DAPK2 |
0.833 | -0.051 | -3 | 0.852 |
LATS2 |
0.833 | 0.003 | -5 | 0.604 |
DLK |
0.833 | -0.048 | 1 | 0.792 |
JNK2 |
0.833 | 0.154 | 1 | 0.697 |
CHAK1 |
0.833 | 0.107 | 2 | 0.746 |
HUNK |
0.833 | -0.126 | 2 | 0.787 |
TSSK2 |
0.832 | -0.018 | -5 | 0.684 |
PRKD2 |
0.832 | 0.037 | -3 | 0.747 |
GRK7 |
0.832 | 0.113 | 1 | 0.733 |
CDK13 |
0.832 | 0.117 | 1 | 0.719 |
P38A |
0.832 | 0.143 | 1 | 0.764 |
PRKD1 |
0.832 | -0.019 | -3 | 0.787 |
P90RSK |
0.832 | -0.017 | -3 | 0.756 |
YSK4 |
0.831 | 0.050 | 1 | 0.780 |
BMPR1B |
0.831 | 0.101 | 1 | 0.725 |
ANKRD3 |
0.831 | -0.058 | 1 | 0.834 |
PKACG |
0.831 | 0.027 | -2 | 0.735 |
CDK17 |
0.831 | 0.144 | 1 | 0.629 |
DYRK2 |
0.831 | 0.106 | 1 | 0.766 |
NIM1 |
0.831 | -0.046 | 3 | 0.759 |
CDK7 |
0.831 | 0.089 | 1 | 0.734 |
JNK3 |
0.831 | 0.138 | 1 | 0.725 |
ERK1 |
0.831 | 0.149 | 1 | 0.701 |
AMPKA2 |
0.830 | -0.001 | -3 | 0.816 |
TSSK1 |
0.830 | 0.006 | -3 | 0.859 |
P70S6KB |
0.830 | -0.009 | -3 | 0.791 |
RSK3 |
0.830 | -0.008 | -3 | 0.751 |
P38G |
0.829 | 0.150 | 1 | 0.625 |
NUAK1 |
0.829 | 0.005 | -3 | 0.789 |
MNK1 |
0.829 | 0.099 | -2 | 0.801 |
P38B |
0.829 | 0.148 | 1 | 0.704 |
BCKDK |
0.829 | -0.127 | -1 | 0.746 |
CDK16 |
0.829 | 0.174 | 1 | 0.644 |
ERK2 |
0.829 | 0.121 | 1 | 0.746 |
MASTL |
0.829 | -0.242 | -2 | 0.846 |
HIPK2 |
0.828 | 0.156 | 1 | 0.694 |
CAMK2D |
0.828 | -0.069 | -3 | 0.814 |
MAPKAPK3 |
0.828 | -0.047 | -3 | 0.756 |
MNK2 |
0.828 | 0.063 | -2 | 0.796 |
ATM |
0.827 | -0.045 | 1 | 0.725 |
HIPK1 |
0.827 | 0.131 | 1 | 0.777 |
AURC |
0.827 | 0.061 | -2 | 0.659 |
TAO3 |
0.826 | 0.189 | 1 | 0.792 |
ALK4 |
0.826 | -0.010 | -2 | 0.854 |
PHKG1 |
0.826 | -0.002 | -3 | 0.819 |
CDK14 |
0.826 | 0.140 | 1 | 0.720 |
GRK4 |
0.826 | -0.096 | -2 | 0.819 |
NEK2 |
0.825 | -0.007 | 2 | 0.798 |
PLK1 |
0.825 | -0.042 | -2 | 0.818 |
CDK10 |
0.825 | 0.179 | 1 | 0.707 |
DNAPK |
0.825 | 0.026 | 1 | 0.739 |
RSK4 |
0.824 | 0.048 | -3 | 0.736 |
CAMK2B |
0.824 | -0.005 | 2 | 0.768 |
QIK |
0.824 | -0.064 | -3 | 0.821 |
QSK |
0.824 | -0.004 | 4 | 0.787 |
PKCT |
0.824 | 0.098 | 2 | 0.765 |
CDK12 |
0.824 | 0.107 | 1 | 0.700 |
MST3 |
0.824 | 0.140 | 2 | 0.836 |
MEK1 |
0.824 | -0.103 | 2 | 0.810 |
MELK |
0.824 | -0.033 | -3 | 0.793 |
PAK1 |
0.824 | -0.006 | -2 | 0.803 |
CDK6 |
0.823 | 0.203 | 1 | 0.702 |
CAMK4 |
0.823 | -0.086 | -3 | 0.823 |
RIPK1 |
0.823 | -0.184 | 1 | 0.801 |
PRKD3 |
0.823 | 0.004 | -3 | 0.731 |
SIK |
0.822 | -0.000 | -3 | 0.762 |
IRAK4 |
0.822 | 0.037 | 1 | 0.788 |
TGFBR1 |
0.822 | 0.019 | -2 | 0.823 |
PHKG2 |
0.822 | 0.077 | -3 | 0.797 |
PINK1 |
0.822 | 0.004 | 1 | 0.826 |
ACVR2A |
0.822 | 0.018 | -2 | 0.810 |
MSK2 |
0.822 | -0.021 | -3 | 0.731 |
PIM2 |
0.822 | 0.036 | -3 | 0.740 |
CDK9 |
0.821 | 0.078 | 1 | 0.729 |
PAK3 |
0.821 | -0.044 | -2 | 0.805 |
MEKK2 |
0.821 | 0.049 | 2 | 0.793 |
MAPKAPK2 |
0.821 | -0.023 | -3 | 0.718 |
TTBK2 |
0.821 | -0.154 | 2 | 0.664 |
PKCE |
0.821 | 0.159 | 2 | 0.764 |
PKCI |
0.820 | 0.104 | 2 | 0.761 |
DYRK1A |
0.820 | 0.095 | 1 | 0.795 |
PAK6 |
0.820 | 0.042 | -2 | 0.746 |
BRAF |
0.820 | -0.009 | -4 | 0.853 |
AKT2 |
0.820 | 0.053 | -3 | 0.688 |
MEKK3 |
0.820 | -0.026 | 1 | 0.789 |
ACVR2B |
0.820 | 0.016 | -2 | 0.816 |
TNIK |
0.820 | 0.280 | 3 | 0.919 |
VRK2 |
0.820 | -0.206 | 1 | 0.844 |
CAMK2A |
0.820 | -0.025 | 2 | 0.776 |
ZAK |
0.819 | -0.023 | 1 | 0.756 |
CHK1 |
0.819 | -0.048 | -3 | 0.810 |
ALK2 |
0.819 | 0.025 | -2 | 0.829 |
MEKK1 |
0.819 | -0.032 | 1 | 0.793 |
MARK3 |
0.819 | -0.002 | 4 | 0.748 |
PKACB |
0.819 | 0.056 | -2 | 0.666 |
AURB |
0.819 | 0.034 | -2 | 0.660 |
P38D |
0.818 | 0.147 | 1 | 0.639 |
HRI |
0.818 | -0.056 | -2 | 0.865 |
HIPK3 |
0.818 | 0.087 | 1 | 0.787 |
TAO2 |
0.818 | 0.132 | 2 | 0.860 |
MYLK4 |
0.818 | -0.006 | -2 | 0.773 |
EEF2K |
0.818 | 0.192 | 3 | 0.921 |
PRKX |
0.818 | 0.094 | -3 | 0.691 |
SGK3 |
0.817 | 0.023 | -3 | 0.752 |
CDK4 |
0.817 | 0.166 | 1 | 0.688 |
GCK |
0.817 | 0.221 | 1 | 0.832 |
WNK4 |
0.817 | -0.036 | -2 | 0.879 |
MEK5 |
0.817 | -0.102 | 2 | 0.804 |
MARK2 |
0.817 | -0.026 | 4 | 0.707 |
PLK4 |
0.817 | -0.036 | 2 | 0.602 |
NEK5 |
0.817 | -0.007 | 1 | 0.813 |
PLK3 |
0.816 | -0.059 | 2 | 0.734 |
MINK |
0.816 | 0.220 | 1 | 0.823 |
HGK |
0.816 | 0.193 | 3 | 0.912 |
PKG2 |
0.816 | 0.022 | -2 | 0.666 |
DYRK1B |
0.816 | 0.095 | 1 | 0.733 |
CAMK1G |
0.816 | -0.014 | -3 | 0.758 |
PERK |
0.816 | -0.091 | -2 | 0.854 |
BMPR1A |
0.816 | 0.081 | 1 | 0.699 |
DRAK1 |
0.815 | -0.070 | 1 | 0.719 |
PRP4 |
0.815 | 0.025 | -3 | 0.709 |
PAK2 |
0.815 | -0.056 | -2 | 0.794 |
KHS2 |
0.815 | 0.272 | 1 | 0.848 |
AKT1 |
0.815 | 0.073 | -3 | 0.703 |
DCAMKL1 |
0.814 | 0.003 | -3 | 0.782 |
MSK1 |
0.814 | 0.001 | -3 | 0.739 |
MPSK1 |
0.814 | 0.049 | 1 | 0.757 |
NEK8 |
0.814 | 0.022 | 2 | 0.813 |
AURA |
0.814 | 0.033 | -2 | 0.640 |
TLK2 |
0.813 | -0.076 | 1 | 0.786 |
DYRK3 |
0.813 | 0.089 | 1 | 0.780 |
ERK7 |
0.813 | 0.061 | 2 | 0.549 |
CK1E |
0.813 | 0.041 | -3 | 0.670 |
MARK1 |
0.813 | -0.043 | 4 | 0.772 |
MST2 |
0.812 | 0.123 | 1 | 0.815 |
GRK2 |
0.812 | -0.061 | -2 | 0.712 |
KHS1 |
0.812 | 0.240 | 1 | 0.837 |
SMG1 |
0.812 | -0.129 | 1 | 0.742 |
GAK |
0.812 | 0.062 | 1 | 0.797 |
BRSK2 |
0.812 | -0.092 | -3 | 0.802 |
DYRK4 |
0.811 | 0.097 | 1 | 0.699 |
BRSK1 |
0.811 | -0.076 | -3 | 0.785 |
NEK11 |
0.811 | -0.014 | 1 | 0.807 |
HPK1 |
0.810 | 0.167 | 1 | 0.836 |
SLK |
0.810 | 0.141 | -2 | 0.748 |
SMMLCK |
0.809 | -0.029 | -3 | 0.806 |
DCAMKL2 |
0.809 | -0.023 | -3 | 0.803 |
MST1 |
0.809 | 0.168 | 1 | 0.810 |
MAK |
0.809 | 0.177 | -2 | 0.804 |
PASK |
0.808 | -0.018 | -3 | 0.845 |
SNRK |
0.808 | -0.176 | 2 | 0.648 |
PDK1 |
0.807 | -0.016 | 1 | 0.811 |
LRRK2 |
0.807 | 0.048 | 2 | 0.826 |
LOK |
0.806 | 0.092 | -2 | 0.801 |
PKN1 |
0.806 | 0.029 | -3 | 0.710 |
SSTK |
0.806 | -0.042 | 4 | 0.776 |
NEK4 |
0.806 | 0.008 | 1 | 0.812 |
CK1D |
0.805 | 0.040 | -3 | 0.623 |
CAMKK1 |
0.805 | -0.074 | -2 | 0.797 |
TLK1 |
0.805 | -0.102 | -2 | 0.823 |
MOK |
0.805 | 0.136 | 1 | 0.781 |
PKACA |
0.805 | 0.038 | -2 | 0.616 |
CK1G1 |
0.803 | 0.024 | -3 | 0.664 |
TAK1 |
0.803 | 0.049 | 1 | 0.815 |
MAP3K15 |
0.802 | -0.011 | 1 | 0.756 |
IRAK1 |
0.802 | -0.185 | -1 | 0.699 |
JNK1 |
0.802 | 0.083 | 1 | 0.680 |
MAPKAPK5 |
0.801 | -0.148 | -3 | 0.698 |
NEK1 |
0.801 | 0.006 | 1 | 0.797 |
PAK5 |
0.800 | -0.005 | -2 | 0.683 |
CK1A2 |
0.800 | 0.024 | -3 | 0.626 |
MEKK6 |
0.800 | -0.051 | 1 | 0.784 |
LKB1 |
0.799 | -0.104 | -3 | 0.799 |
P70S6K |
0.799 | -0.062 | -3 | 0.696 |
GSK3A |
0.799 | -0.019 | 4 | 0.382 |
MRCKB |
0.799 | 0.058 | -3 | 0.737 |
YSK1 |
0.799 | 0.047 | 2 | 0.805 |
CAMKK2 |
0.799 | -0.106 | -2 | 0.798 |
ROCK2 |
0.799 | 0.071 | -3 | 0.785 |
CAMK1D |
0.799 | -0.030 | -3 | 0.683 |
AKT3 |
0.798 | 0.049 | -3 | 0.618 |
MRCKA |
0.798 | 0.053 | -3 | 0.751 |
CHK2 |
0.798 | 0.008 | -3 | 0.630 |
DAPK3 |
0.798 | -0.014 | -3 | 0.801 |
GSK3B |
0.796 | -0.075 | 4 | 0.369 |
MYO3A |
0.795 | 0.185 | 1 | 0.820 |
SGK1 |
0.795 | 0.027 | -3 | 0.607 |
TTBK1 |
0.795 | -0.178 | 2 | 0.586 |
GRK3 |
0.795 | -0.069 | -2 | 0.661 |
PAK4 |
0.794 | -0.012 | -2 | 0.689 |
STK33 |
0.794 | -0.073 | 2 | 0.585 |
CK2A2 |
0.794 | 0.005 | 1 | 0.620 |
BUB1 |
0.794 | 0.027 | -5 | 0.635 |
TTK |
0.793 | 0.052 | -2 | 0.820 |
PLK2 |
0.792 | -0.014 | -3 | 0.820 |
VRK1 |
0.792 | -0.135 | 2 | 0.835 |
MYO3B |
0.791 | 0.116 | 2 | 0.819 |
DMPK1 |
0.791 | 0.064 | -3 | 0.762 |
OSR1 |
0.790 | 0.062 | 2 | 0.777 |
HASPIN |
0.790 | 0.023 | -1 | 0.643 |
TAO1 |
0.789 | 0.086 | 1 | 0.746 |
DAPK1 |
0.788 | -0.040 | -3 | 0.786 |
CAMK1A |
0.788 | -0.023 | -3 | 0.650 |
PBK |
0.787 | -0.046 | 1 | 0.728 |
MEK2 |
0.787 | -0.188 | 2 | 0.779 |
ROCK1 |
0.787 | 0.056 | -3 | 0.752 |
RIPK2 |
0.785 | -0.211 | 1 | 0.725 |
ALPHAK3 |
0.785 | 0.024 | -1 | 0.726 |
NEK3 |
0.782 | -0.126 | 1 | 0.764 |
CK2A1 |
0.782 | -0.026 | 1 | 0.599 |
SBK |
0.781 | -0.017 | -3 | 0.563 |
BIKE |
0.779 | -0.007 | 1 | 0.682 |
PDHK3_TYR |
0.778 | 0.089 | 4 | 0.871 |
ASK1 |
0.776 | -0.093 | 1 | 0.740 |
CRIK |
0.775 | -0.011 | -3 | 0.689 |
PKG1 |
0.774 | -0.034 | -2 | 0.582 |
YANK3 |
0.772 | -0.063 | 2 | 0.364 |
TESK1_TYR |
0.772 | -0.022 | 3 | 0.869 |
PINK1_TYR |
0.770 | 0.004 | 1 | 0.804 |
PDHK4_TYR |
0.769 | 0.012 | 2 | 0.842 |
MAP2K6_TYR |
0.769 | -0.008 | -1 | 0.829 |
LIMK2_TYR |
0.768 | 0.036 | -3 | 0.861 |
MAP2K7_TYR |
0.767 | -0.141 | 2 | 0.831 |
MAP2K4_TYR |
0.767 | -0.116 | -1 | 0.822 |
PKMYT1_TYR |
0.766 | -0.104 | 3 | 0.826 |
BMPR2_TYR |
0.766 | -0.036 | -1 | 0.793 |
PDHK1_TYR |
0.765 | -0.026 | -1 | 0.834 |
AAK1 |
0.764 | 0.026 | 1 | 0.588 |
TYK2 |
0.763 | -0.044 | 1 | 0.797 |
ROS1 |
0.762 | -0.019 | 3 | 0.784 |
STLK3 |
0.762 | -0.150 | 1 | 0.732 |
LIMK1_TYR |
0.762 | -0.072 | 2 | 0.840 |
RET |
0.760 | -0.089 | 1 | 0.794 |
TYRO3 |
0.758 | -0.090 | 3 | 0.810 |
CSF1R |
0.758 | -0.044 | 3 | 0.776 |
JAK2 |
0.758 | -0.077 | 1 | 0.793 |
EPHA6 |
0.758 | -0.056 | -1 | 0.766 |
CK1A |
0.756 | -0.029 | -3 | 0.545 |
MST1R |
0.756 | -0.134 | 3 | 0.794 |
FLT3 |
0.755 | -0.022 | 3 | 0.807 |
INSRR |
0.754 | -0.054 | 3 | 0.744 |
ABL2 |
0.754 | -0.045 | -1 | 0.724 |
TNNI3K_TYR |
0.754 | 0.014 | 1 | 0.777 |
JAK3 |
0.753 | -0.098 | 1 | 0.757 |
JAK1 |
0.752 | 0.007 | 1 | 0.759 |
EPHB4 |
0.752 | -0.112 | -1 | 0.747 |
YES1 |
0.752 | -0.073 | -1 | 0.761 |
FGR |
0.751 | -0.107 | 1 | 0.783 |
DDR1 |
0.751 | -0.184 | 4 | 0.794 |
WEE1_TYR |
0.751 | 0.013 | -1 | 0.687 |
NEK10_TYR |
0.751 | -0.024 | 1 | 0.710 |
TNK1 |
0.750 | -0.051 | 3 | 0.772 |
LCK |
0.750 | -0.019 | -1 | 0.731 |
FER |
0.750 | -0.134 | 1 | 0.793 |
PDGFRB |
0.749 | -0.116 | 3 | 0.802 |
CK1G3 |
0.749 | 0.006 | -3 | 0.503 |
KIT |
0.748 | -0.102 | 3 | 0.774 |
TXK |
0.747 | -0.028 | 1 | 0.736 |
BLK |
0.747 | -0.006 | -1 | 0.738 |
HCK |
0.747 | -0.110 | -1 | 0.729 |
ABL1 |
0.746 | -0.103 | -1 | 0.715 |
KDR |
0.746 | -0.105 | 3 | 0.746 |
FGFR2 |
0.745 | -0.160 | 3 | 0.765 |
EPHA4 |
0.745 | -0.094 | 2 | 0.741 |
TNK2 |
0.744 | -0.128 | 3 | 0.723 |
ITK |
0.744 | -0.103 | -1 | 0.706 |
TEK |
0.744 | -0.155 | 3 | 0.739 |
YANK2 |
0.743 | -0.079 | 2 | 0.390 |
PDGFRA |
0.742 | -0.171 | 3 | 0.804 |
SRMS |
0.742 | -0.149 | 1 | 0.773 |
EPHB1 |
0.741 | -0.161 | 1 | 0.773 |
BTK |
0.741 | -0.146 | -1 | 0.673 |
ALK |
0.741 | -0.133 | 3 | 0.722 |
TEC |
0.740 | -0.098 | -1 | 0.638 |
FGFR1 |
0.740 | -0.189 | 3 | 0.748 |
EPHB2 |
0.738 | -0.138 | -1 | 0.719 |
EPHB3 |
0.738 | -0.176 | -1 | 0.729 |
AXL |
0.737 | -0.194 | 3 | 0.745 |
BMX |
0.737 | -0.098 | -1 | 0.613 |
MET |
0.737 | -0.152 | 3 | 0.757 |
FYN |
0.736 | -0.051 | -1 | 0.701 |
INSR |
0.736 | -0.141 | 3 | 0.723 |
MERTK |
0.736 | -0.166 | 3 | 0.736 |
LTK |
0.736 | -0.160 | 3 | 0.727 |
FLT1 |
0.736 | -0.127 | -1 | 0.756 |
FRK |
0.736 | -0.107 | -1 | 0.741 |
FGFR3 |
0.735 | -0.159 | 3 | 0.743 |
MATK |
0.734 | -0.087 | -1 | 0.667 |
LYN |
0.734 | -0.110 | 3 | 0.708 |
ERBB2 |
0.734 | -0.164 | 1 | 0.734 |
NTRK1 |
0.733 | -0.211 | -1 | 0.735 |
PTK6 |
0.733 | -0.211 | -1 | 0.653 |
DDR2 |
0.732 | -0.100 | 3 | 0.729 |
NTRK2 |
0.732 | -0.207 | 3 | 0.734 |
FLT4 |
0.732 | -0.189 | 3 | 0.724 |
EPHA7 |
0.730 | -0.152 | 2 | 0.747 |
EPHA3 |
0.728 | -0.204 | 2 | 0.714 |
EPHA1 |
0.728 | -0.208 | 3 | 0.743 |
CK1G2 |
0.727 | -0.027 | -3 | 0.591 |
NTRK3 |
0.727 | -0.179 | -1 | 0.692 |
SRC |
0.725 | -0.125 | -1 | 0.704 |
EGFR |
0.725 | -0.106 | 1 | 0.629 |
CSK |
0.725 | -0.144 | 2 | 0.741 |
EPHA5 |
0.725 | -0.138 | 2 | 0.732 |
EPHA8 |
0.722 | -0.141 | -1 | 0.707 |
PTK2B |
0.722 | -0.180 | -1 | 0.677 |
PTK2 |
0.722 | -0.066 | -1 | 0.684 |
FGFR4 |
0.722 | -0.115 | -1 | 0.692 |
MUSK |
0.721 | -0.131 | 1 | 0.630 |
IGF1R |
0.721 | -0.138 | 3 | 0.663 |
SYK |
0.720 | -0.056 | -1 | 0.684 |
ERBB4 |
0.712 | -0.102 | 1 | 0.639 |
EPHA2 |
0.711 | -0.162 | -1 | 0.667 |
FES |
0.699 | -0.204 | -1 | 0.597 |
ZAP70 |
0.699 | -0.086 | -1 | 0.611 |