Motif 628 (n=196)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WZ62 | None | S246 | ochoa | Mannosyltransferase (EC 2.4.1.-) | None |
| A0A0A6YYH1 | C15orf38-AP3S2 | S98 | ochoa | Arpin | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000256|ARBA:ARBA00025605}. |
| A0A0U1RQV5 | None | S27 | ochoa | Eukaryotic translation initiation factor 6 | None |
| A0MZ66 | SHTN1 | S561 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A4D1P6 | WDR91 | S326 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
| A6NKT7 | RGPD3 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1587 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MTJ3 | GNAT3 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| O00515 | LAD1 | S485 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00571 | DDX3X | S31 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14640 | DVL1 | S676 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14715 | RGPD8 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14715 | RGPD8 | S1586 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14733 | MAP2K7 | S271 | psp | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14818 | PSMA7 | S30 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O14976 | GAK | S21 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15446 | POLR1G | S66 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43678 | NDUFA2 | S27 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O43683 | BUB1 | S176 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60361 | NME2P1 | S107 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60437 | PPL | S1657 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60566 | BUB1B | S270 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60684 | KPNA6 | S459 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75369 | FLNB | S755 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75427 | LRCH4 | S307 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75469 | NR1I2 | S167 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75943 | RAD17 | S367 | psp | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O94986 | CEP152 | S83 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O94988 | FAM13A | S555 | ochoa | Protein FAM13A | None |
| O95196 | CSPG5 | S28 | ochoa | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}. |
| O95394 | PGM3 | S498 | ochoa | Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) | Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}. |
| O95684 | CEP43 | S207 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95810 | CAVIN2 | S169 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P00533 | EGFR | S720 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04233 | CD74 | S25 | ochoa|psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
| P04350 | TUBB4A | S95 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04626 | ERBB2 | S703 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04626 | ERBB2 | S728 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04899 | GNAI2 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05187 | ALPP | S436 | ochoa | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P06732 | CKM | S285 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P06746 | POLB | S55 | psp | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:10556592, PubMed:17526740, PubMed:9556598, PubMed:9572863, PubMed:9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). {ECO:0000269|PubMed:10556592, ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:17526740, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9556598, ECO:0000269|PubMed:9572863, ECO:0000269|PubMed:9614142}. |
| P07437 | TUBB | S95 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08069 | IGF1R | S975 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08514 | ITGA2B | S432 | ochoa | Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:9111081}. |
| P08754 | GNAI3 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P0DJD0 | RGPD1 | S962 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S970 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10636 | MAPT | S46 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10696 | ALPG | S433 | ochoa | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P11142 | HSPA8 | S221 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12532 | CKMT1A | S318 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P13693 | TPT1 | S64 | psp | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
| P15531 | NME1 | S122 | ochoa|psp | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P17540 | CKMT2 | S319 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P20290 | BTF3 | S173 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P20963 | CD247 | S58 | ochoa | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:1384049, PubMed:1385158, PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}. |
| P21860 | ERBB3 | S717 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P21860 | ERBB3 | S1094 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22392 | NME2 | S122 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P25788 | PSMA3 | S35 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P29401 | TKT | S345 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29590 | PML | S547 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P31939 | ATIC | S450 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P33981 | TTK | S80 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P33981 | TTK | S824 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35609 | ACTN2 | S201 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P38936 | CDKN1A | S31 | ochoa | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P39687 | ANP32A | S27 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P39880 | CUX1 | S1337 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40818 | USP8 | S160 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P41229 | KDM5C | S1359 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P42166 | TMPO | S459 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42768 | WAS | S483 | ochoa|psp | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P45985 | MAP2K4 | S257 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46013 | MKI67 | S325 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46734 | MAP2K3 | S218 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P49756 | RBM25 | S703 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49792 | RANBP2 | S1953 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2562 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50851 | LRBA | S1785 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51587 | BRCA2 | S581 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51825 | AFF1 | S172 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52564 | MAP2K6 | S207 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}. |
| P54652 | HSPA2 | S224 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P54792 | DVL1P1 | S651 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P56537 | EIF6 | S175 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
| P60880 | SNAP25 | S154 | ochoa | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}. |
| P61925 | PKIA | S35 | ochoa | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| P61978 | HNRNPK | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P61981 | YWHAG | S71 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62857 | RPS28 | S39 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| P63096 | GNAI1 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P68371 | TUBB4B | S95 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78367 | NKX3-2 | S73 | ochoa | Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B) | Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}. |
| Q04837 | SSBP1 | S67 | ochoa | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
| Q05655 | PRKCD | S331 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q08170 | SRSF4 | S113 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q12913 | PTPRJ | S1011 | ochoa | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q13243 | SRSF5 | S117 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13247 | SRSF6 | S119 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13885 | TUBB2A | S95 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14004 | CDK13 | S867 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14204 | DYNC1H1 | S3917 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14315 | FLNC | S762 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14624 | ITIH4 | S622 | ochoa | Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:19263524}. |
| Q14676 | MDC1 | S1786 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14699 | RFTN1 | S555 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q15084 | PDIA6 | S394 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15303 | ERBB4 | S726 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q16576 | RBBP7 | S99 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16828 | DUSP6 | S328 | ochoa | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
| Q4V328 | GRIPAP1 | S321 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q5M7Z0 | RNFT1 | S76 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5T200 | ZC3H13 | S1455 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5P2 | KIAA1217 | S526 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5P2 | KIAA1217 | S1551 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VT52 | RPRD2 | S356 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YH5 | CDCA2 | S24 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6BDS2 | BLTP3A | S957 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6NYC8 | PPP1R18 | S307 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6NZY4 | ZCCHC8 | S331 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6PJT7 | ZC3H14 | S240 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q70CQ2 | USP34 | S490 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70EL4 | USP43 | S818 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1587 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6K5 | ARPIN | S98 | ochoa | Arpin (Arp2/3 inhibition protein) | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}. |
| Q7Z7L1 | SLFN11 | S750 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86T90 | KIAA1328 | S81 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86YV5 | PRAG1 | S219 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVF2 | AHNAK2 | S102 | ochoa | Protein AHNAK2 | None |
| Q8IY92 | SLX4 | S57 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N302 | AGGF1 | S176 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4X5 | AFAP1L2 | S303 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8NF99 | ZNF397 | S31 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8TBN0 | RAB3IL1 | S66 | ochoa | Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}. |
| Q8WVV9 | HNRNPLL | S73 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q8WWI1 | LMO7 | S217 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWK9 | CKAP2 | S602 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q92932 | PTPRN2 | S652 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
| Q96AJ9 | VTI1A | S96 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Q96B36 | AKT1S1 | S183 | ochoa|psp | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
| Q96FS4 | SIPA1 | S912 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96IF1 | AJUBA | S263 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96KN1 | LRATD2 | S179 | ochoa | Protein LRATD2 (Breast cancer membrane protein 101) (LRAT domain-containing 2) (Protein FAM84B) (Protein NSE2) | None |
| Q96P70 | IPO9 | S890 | ochoa | Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:Q91YE6, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:30855230, ECO:0000269|PubMed:34711951}. |
| Q96PU5 | NEDD4L | S377 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96RT1 | ERBIN | S870 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99569 | PKP4 | S143 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99666 | RGPD5 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99666 | RGPD5 | S1586 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BTE7 | DCUN1D5 | S47 | ochoa | DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5) | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:19617556, PubMed:23201271, PubMed:26906416). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928). {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23098533, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:24192928, ECO:0000269|PubMed:26906416}. |
| Q9BVA1 | TUBB2B | S95 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXS6 | NUSAP1 | S276 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BYX4 | IFIH1 | S828 | psp | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}. |
| Q9C0C2 | TNKS1BP1 | S195 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY8 | MFF | S74 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H0G5 | NSRP1 | S27 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H223 | EHD4 | S406 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H4B7 | TUBB1 | S95 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H4L5 | OSBPL3 | S764 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H910 | JPT2 | S125 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HC44 | GPBP1L1 | S21 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NR09 | BIRC6 | S462 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NYL9 | TMOD3 | S155 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NYV4 | CDK12 | S889 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9UGU0 | TCF20 | S983 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UKK3 | PARP4 | S1511 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UMS4 | PRPF19 | S148 | ochoa | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6, ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718, ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800, ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876, ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154, ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}. |
| Q9UN79 | SOX13 | S386 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UQ35 | SRRM2 | S1348 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2I9 | TBC1D30 | S744 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y6I4 | USP3 | S350 | ochoa | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}. |
| Q9Y6N7 | ROBO1 | S1081 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| P00441 | SOD1 | S106 | Sugiyama | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P39687 | ANP32A | S117 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| Q15648 | MED1 | S932 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q92688 | ANP32B | S117 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| Q08J23 | NSUN2 | S383 | Sugiyama | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| P29401 | TKT | S443 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| Q96PH1 | NOX5 | S536 | SIGNOR | NADPH oxidase 5 (EC 1.6.3.-) | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}. |
| P24752 | ACAT1 | S69 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| Q9NZV7 | ZIM2 | S158 | Sugiyama | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9UBS5 | GABBR1 | S868 | SIGNOR | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:24305054, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9844003, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:24305054, PubMed:9844003, PubMed:9872316). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10773016, ECO:0000269|PubMed:10906333, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:36103875, ECO:0000269|PubMed:9844003, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.; FUNCTION: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. |
| P39019 | RPS19 | S98 | Sugiyama | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P31947 | SFN | S64 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P46940 | IQGAP1 | S1362 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| O14910 | LIN7A | S157 | Sugiyama | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
| Q9NUP9 | LIN7C | S142 | Sugiyama | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}. |
| P16333 | NCK1 | S320 | Sugiyama | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| Q9NQE9 | HINT3 | S46 | Sugiyama | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| P05187 | ALPP | S153 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P09923 | ALPI | S150 | Sugiyama | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P10696 | ALPG | S150 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| Q10570 | CPSF1 | S712 | Sugiyama | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.257902e-08 | 7.900 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.788588e-09 | 8.056 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 6.451629e-08 | 7.190 |
| R-HSA-69275 | G2/M Transition | 5.565986e-08 | 7.254 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.341975e-08 | 7.198 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.806155e-08 | 7.318 |
| R-HSA-9833482 | PKR-mediated signaling | 7.441506e-08 | 7.128 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.338428e-07 | 6.873 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.944120e-07 | 6.711 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.756156e-07 | 6.755 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.880405e-07 | 6.541 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.148460e-07 | 6.502 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 3.937557e-07 | 6.405 |
| R-HSA-1640170 | Cell Cycle | 6.333203e-07 | 6.198 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.278768e-07 | 6.138 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 7.208350e-07 | 6.142 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 8.725097e-07 | 6.059 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.160264e-07 | 6.038 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.221141e-07 | 6.035 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.050081e-06 | 5.979 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.050081e-06 | 5.979 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.182034e-06 | 5.927 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.427114e-06 | 5.846 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.796841e-06 | 5.745 |
| R-HSA-68877 | Mitotic Prometaphase | 2.656534e-06 | 5.576 |
| R-HSA-9646399 | Aggrephagy | 5.953431e-06 | 5.225 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.701436e-06 | 5.013 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.113857e-05 | 4.953 |
| R-HSA-2262752 | Cellular responses to stress | 1.261412e-05 | 4.899 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.407639e-05 | 4.852 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.455270e-05 | 4.837 |
| R-HSA-437239 | Recycling pathway of L1 | 1.626343e-05 | 4.789 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.815429e-05 | 4.741 |
| R-HSA-373760 | L1CAM interactions | 2.044865e-05 | 4.689 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.328372e-05 | 4.633 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.461936e-05 | 4.609 |
| R-HSA-112316 | Neuronal System | 2.627449e-05 | 4.580 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.805809e-05 | 4.552 |
| R-HSA-190861 | Gap junction assembly | 3.070350e-05 | 4.513 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.323775e-05 | 4.478 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 3.743326e-05 | 4.427 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.825622e-05 | 4.417 |
| R-HSA-68882 | Mitotic Anaphase | 3.954847e-05 | 4.403 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.127090e-05 | 4.384 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.218921e-05 | 4.282 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.973697e-05 | 4.224 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.668529e-05 | 4.176 |
| R-HSA-9609690 | HCMV Early Events | 6.926815e-05 | 4.159 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 7.810471e-05 | 4.107 |
| R-HSA-68886 | M Phase | 7.410682e-05 | 4.130 |
| R-HSA-913531 | Interferon Signaling | 7.634245e-05 | 4.117 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.032058e-05 | 4.095 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.032058e-05 | 4.095 |
| R-HSA-9663891 | Selective autophagy | 8.590638e-05 | 4.066 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 9.471043e-05 | 4.024 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 9.471043e-05 | 4.024 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.035541e-04 | 3.985 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.123557e-04 | 3.949 |
| R-HSA-190828 | Gap junction trafficking | 1.123557e-04 | 3.949 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.183033e-04 | 3.927 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.518893e-04 | 3.818 |
| R-HSA-9609646 | HCMV Infection | 1.496037e-04 | 3.825 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.721738e-04 | 3.764 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.794190e-04 | 3.746 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.838471e-04 | 3.736 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.057493e-04 | 3.687 |
| R-HSA-380287 | Centrosome maturation | 2.078365e-04 | 3.682 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.263618e-04 | 3.645 |
| R-HSA-5617833 | Cilium Assembly | 2.285596e-04 | 3.641 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.513309e-04 | 3.600 |
| R-HSA-1643685 | Disease | 2.582205e-04 | 3.588 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.950019e-04 | 3.530 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.994130e-04 | 3.524 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.000263e-04 | 3.523 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.099270e-04 | 3.509 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.682655e-04 | 3.434 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.065657e-04 | 3.391 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.259282e-04 | 3.371 |
| R-HSA-983189 | Kinesins | 4.661832e-04 | 3.331 |
| R-HSA-373753 | Nephrin family interactions | 4.830436e-04 | 3.316 |
| R-HSA-422475 | Axon guidance | 5.080490e-04 | 3.294 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 5.539791e-04 | 3.257 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 5.589069e-04 | 3.253 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.832924e-04 | 3.234 |
| R-HSA-8848021 | Signaling by PTK6 | 5.832924e-04 | 3.234 |
| R-HSA-74160 | Gene expression (Transcription) | 5.484810e-04 | 3.261 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.907052e-04 | 3.229 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 7.117745e-04 | 3.148 |
| R-HSA-977444 | GABA B receptor activation | 7.995826e-04 | 3.097 |
| R-HSA-991365 | Activation of GABAB receptors | 7.995826e-04 | 3.097 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.424724e-04 | 3.074 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 9.259281e-04 | 3.033 |
| R-HSA-9675108 | Nervous system development | 1.068786e-03 | 2.971 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.008574e-03 | 2.996 |
| R-HSA-9620244 | Long-term potentiation | 1.069114e-03 | 2.971 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.141980e-03 | 2.942 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.218155e-03 | 2.914 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.274914e-03 | 2.895 |
| R-HSA-5620924 | Intraflagellar transport | 1.316316e-03 | 2.881 |
| R-HSA-428540 | Activation of RAC1 | 1.347538e-03 | 2.870 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 1.538225e-03 | 2.813 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 1.538225e-03 | 2.813 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 1.538225e-03 | 2.813 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 1.538225e-03 | 2.813 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 1.538225e-03 | 2.813 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 1.538225e-03 | 2.813 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 1.538225e-03 | 2.813 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 1.538225e-03 | 2.813 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 1.538225e-03 | 2.813 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 1.538225e-03 | 2.813 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 1.538225e-03 | 2.813 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 1.538225e-03 | 2.813 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.421895e-03 | 2.847 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.421895e-03 | 2.847 |
| R-HSA-212436 | Generic Transcription Pathway | 1.530879e-03 | 2.815 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.618537e-03 | 2.791 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.662621e-03 | 2.779 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.699046e-03 | 2.770 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.776151e-03 | 2.751 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.988774e-03 | 2.701 |
| R-HSA-5663205 | Infectious disease | 2.013266e-03 | 2.696 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.040787e-03 | 2.690 |
| R-HSA-1632852 | Macroautophagy | 2.052641e-03 | 2.688 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.184186e-03 | 2.661 |
| R-HSA-418597 | G alpha (z) signalling events | 2.191148e-03 | 2.659 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.453346e-03 | 2.610 |
| R-HSA-977443 | GABA receptor activation | 3.033581e-03 | 2.518 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3.032956e-03 | 2.518 |
| R-HSA-450294 | MAP kinase activation | 3.226637e-03 | 2.491 |
| R-HSA-392518 | Signal amplification | 2.931829e-03 | 2.533 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.999804e-03 | 2.523 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 3.397202e-03 | 2.469 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 3.397202e-03 | 2.469 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 3.397202e-03 | 2.469 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 3.474922e-03 | 2.459 |
| R-HSA-9824446 | Viral Infection Pathways | 3.618136e-03 | 2.442 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.639054e-03 | 2.439 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.662792e-03 | 2.436 |
| R-HSA-9612973 | Autophagy | 3.671580e-03 | 2.435 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.922817e-03 | 2.406 |
| R-HSA-69481 | G2/M Checkpoints | 4.447859e-03 | 2.352 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 4.472006e-03 | 2.349 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.503231e-03 | 2.346 |
| R-HSA-112040 | G-protein mediated events | 4.575176e-03 | 2.340 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.741957e-03 | 2.324 |
| R-HSA-72172 | mRNA Splicing | 5.051739e-03 | 2.297 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.928385e-03 | 2.227 |
| R-HSA-71288 | Creatine metabolism | 5.625784e-03 | 2.250 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.971679e-03 | 2.224 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.539255e-03 | 2.257 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.591267e-03 | 2.252 |
| R-HSA-448424 | Interleukin-17 signaling | 5.381413e-03 | 2.269 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.830059e-03 | 2.234 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.599374e-03 | 2.180 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.606113e-03 | 2.180 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 6.942424e-03 | 2.158 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.053315e-03 | 2.152 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 7.183146e-03 | 2.144 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.421892e-03 | 2.129 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.421892e-03 | 2.129 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 7.663499e-03 | 2.116 |
| R-HSA-2559583 | Cellular Senescence | 7.992496e-03 | 2.097 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.014026e-03 | 2.096 |
| R-HSA-202403 | TCR signaling | 8.325802e-03 | 2.080 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.577814e-03 | 2.067 |
| R-HSA-9634597 | GPER1 signaling | 8.665967e-03 | 2.062 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 9.617923e-03 | 2.017 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.722392e-03 | 2.012 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.809041e-03 | 2.008 |
| R-HSA-8953854 | Metabolism of RNA | 1.066760e-02 | 1.972 |
| R-HSA-72187 | mRNA 3'-end processing | 1.093556e-02 | 1.961 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.097364e-02 | 1.960 |
| R-HSA-8939211 | ESR-mediated signaling | 1.173838e-02 | 1.930 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.241780e-02 | 1.906 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.285434e-02 | 1.891 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.393089e-02 | 1.856 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.461817e-02 | 1.835 |
| R-HSA-391251 | Protein folding | 1.572444e-02 | 1.803 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.953740e-02 | 1.709 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.735425e-02 | 1.761 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.694537e-02 | 1.771 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.717658e-02 | 1.765 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.953740e-02 | 1.709 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.026867e-02 | 1.693 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.026867e-02 | 1.693 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.026867e-02 | 1.693 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.052281e-02 | 1.688 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.098087e-02 | 1.678 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.106340e-02 | 1.676 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.106340e-02 | 1.676 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.202585e-02 | 1.657 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.202585e-02 | 1.657 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.241317e-02 | 1.649 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.270975e-02 | 1.644 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.380908e-02 | 1.623 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.463790e-02 | 1.608 |
| R-HSA-111885 | Opioid Signalling | 2.478647e-02 | 1.606 |
| R-HSA-4641258 | Degradation of DVL | 2.525111e-02 | 1.598 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.572514e-02 | 1.590 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.642497e-02 | 1.578 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.673920e-02 | 1.573 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.726955e-02 | 1.564 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.786291e-02 | 1.555 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.786291e-02 | 1.555 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.792223e-02 | 1.554 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.792223e-02 | 1.554 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.897035e-02 | 1.538 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.900985e-02 | 1.537 |
| R-HSA-199991 | Membrane Trafficking | 2.974414e-02 | 1.527 |
| R-HSA-202433 | Generation of second messenger molecules | 2.985322e-02 | 1.525 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.990575e-02 | 1.524 |
| R-HSA-1280218 | Adaptive Immune System | 3.009775e-02 | 1.521 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.021716e-02 | 1.520 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3.021716e-02 | 1.520 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.021716e-02 | 1.520 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.624471e-02 | 1.441 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.486687e-02 | 1.458 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.464602e-02 | 1.460 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.843557e-02 | 1.415 |
| R-HSA-5693538 | Homology Directed Repair | 4.091696e-02 | 1.388 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.147891e-02 | 1.502 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.624471e-02 | 1.441 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.315019e-02 | 1.480 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.526322e-02 | 1.453 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.753911e-02 | 1.426 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 3.624471e-02 | 1.441 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.081894e-02 | 1.511 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.081894e-02 | 1.511 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.366295e-02 | 1.473 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.666515e-02 | 1.436 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.931441e-02 | 1.405 |
| R-HSA-6798695 | Neutrophil degranulation | 4.106743e-02 | 1.387 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 4.159086e-02 | 1.381 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 4.159086e-02 | 1.381 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.202468e-02 | 1.376 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.202468e-02 | 1.376 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.202468e-02 | 1.376 |
| R-HSA-9675135 | Diseases of DNA repair | 4.218309e-02 | 1.375 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.245145e-02 | 1.372 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 4.269138e-02 | 1.370 |
| R-HSA-162582 | Signal Transduction | 4.321271e-02 | 1.364 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.429040e-02 | 1.354 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.429414e-02 | 1.354 |
| R-HSA-109581 | Apoptosis | 4.438232e-02 | 1.353 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.545595e-02 | 1.342 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.545595e-02 | 1.342 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.573719e-02 | 1.340 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.573719e-02 | 1.340 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.663583e-02 | 1.331 |
| R-HSA-445144 | Signal transduction by L1 | 4.952931e-02 | 1.305 |
| R-HSA-6807004 | Negative regulation of MET activity | 4.952931e-02 | 1.305 |
| R-HSA-1500931 | Cell-Cell communication | 5.149589e-02 | 1.288 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.231876e-02 | 1.281 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.231876e-02 | 1.281 |
| R-HSA-114608 | Platelet degranulation | 5.280719e-02 | 1.277 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 5.308662e-02 | 1.275 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.336287e-02 | 1.273 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.447463e-02 | 1.264 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.667253e-02 | 1.247 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.672793e-02 | 1.246 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 5.673182e-02 | 1.246 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 5.673182e-02 | 1.246 |
| R-HSA-9755088 | Ribavirin ADME | 5.673182e-02 | 1.246 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.835669e-02 | 1.165 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 6.046179e-02 | 1.219 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 8.616571e-02 | 1.065 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.428751e-02 | 1.129 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 8.027750e-02 | 1.095 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.119279e-02 | 1.213 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.351430e-02 | 1.197 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 7.616860e-02 | 1.118 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.351430e-02 | 1.197 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.924021e-02 | 1.160 |
| R-HSA-9658195 | Leishmania infection | 6.642709e-02 | 1.178 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.642709e-02 | 1.178 |
| R-HSA-1234174 | Cellular response to hypoxia | 8.616571e-02 | 1.065 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.220974e-02 | 1.206 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.827389e-02 | 1.106 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.571747e-02 | 1.121 |
| R-HSA-422356 | Regulation of insulin secretion | 7.054761e-02 | 1.152 |
| R-HSA-3214842 | HDMs demethylate histones | 7.212974e-02 | 1.142 |
| R-HSA-1266738 | Developmental Biology | 6.505411e-02 | 1.187 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 6.427342e-02 | 1.192 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 7.616860e-02 | 1.118 |
| R-HSA-163685 | Integration of energy metabolism | 6.798110e-02 | 1.168 |
| R-HSA-168256 | Immune System | 6.154987e-02 | 1.211 |
| R-HSA-109582 | Hemostasis | 6.676710e-02 | 1.175 |
| R-HSA-6807070 | PTEN Regulation | 7.249857e-02 | 1.140 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.871500e-02 | 1.163 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 6.816372e-02 | 1.166 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.619454e-02 | 1.118 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.942804e-02 | 1.226 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.946899e-02 | 1.158 |
| R-HSA-449147 | Signaling by Interleukins | 7.725556e-02 | 1.112 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.942804e-02 | 1.226 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.870999e-02 | 1.052 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 9.232034e-02 | 1.035 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 9.299722e-02 | 1.032 |
| R-HSA-114452 | Activation of BH3-only proteins | 9.299722e-02 | 1.032 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.301753e-02 | 1.031 |
| R-HSA-73894 | DNA Repair | 9.325381e-02 | 1.030 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 9.437821e-02 | 1.025 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 9.437821e-02 | 1.025 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.666543e-02 | 1.015 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9.735940e-02 | 1.012 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 9.735940e-02 | 1.012 |
| R-HSA-186763 | Downstream signal transduction | 9.735940e-02 | 1.012 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.746709e-02 | 1.011 |
| R-HSA-5688426 | Deubiquitination | 9.810079e-02 | 1.008 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.017785e-01 | 0.992 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.017785e-01 | 0.992 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 1.071163e-01 | 0.970 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.071163e-01 | 0.970 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.071163e-01 | 0.970 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.071163e-01 | 0.970 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.196760e-01 | 0.922 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 1.196760e-01 | 0.922 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 1.196760e-01 | 0.922 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.320598e-01 | 0.879 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.320598e-01 | 0.879 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.442702e-01 | 0.841 |
| R-HSA-9613354 | Lipophagy | 1.563095e-01 | 0.806 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.563095e-01 | 0.806 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.563095e-01 | 0.806 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.563095e-01 | 0.806 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.798845e-01 | 0.745 |
| R-HSA-2022923 | DS-GAG biosynthesis | 1.914249e-01 | 0.718 |
| R-HSA-390522 | Striated Muscle Contraction | 1.107777e-01 | 0.956 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.246440e-01 | 0.904 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.388984e-01 | 0.857 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.437263e-01 | 0.842 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.914249e-01 | 0.718 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.563095e-01 | 0.806 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.733607e-01 | 0.761 |
| R-HSA-774815 | Nucleosome assembly | 1.733607e-01 | 0.761 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.029034e-01 | 0.988 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.107777e-01 | 0.956 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.320598e-01 | 0.879 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.028036e-01 | 0.693 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.062520e-01 | 0.974 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.062520e-01 | 0.974 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.293552e-01 | 0.888 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.534848e-01 | 0.814 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.584117e-01 | 0.800 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.239045e-01 | 0.907 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 2.028036e-01 | 0.693 |
| R-HSA-3371568 | Attenuation phase | 1.437263e-01 | 0.842 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.177525e-01 | 0.929 |
| R-HSA-8951664 | Neddylation | 1.294870e-01 | 0.888 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.485890e-01 | 0.828 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.485890e-01 | 0.828 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.534848e-01 | 0.814 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.783941e-01 | 0.749 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.783941e-01 | 0.749 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.783941e-01 | 0.749 |
| R-HSA-9907900 | Proteasome assembly | 1.683514e-01 | 0.774 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.681802e-01 | 0.774 |
| R-HSA-202670 | ERKs are inactivated | 1.914249e-01 | 0.718 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.437263e-01 | 0.842 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.783941e-01 | 0.749 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.788231e-01 | 0.748 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.783941e-01 | 0.749 |
| R-HSA-3371556 | Cellular response to heat stress | 1.264700e-01 | 0.898 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.563095e-01 | 0.806 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.437263e-01 | 0.842 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.437263e-01 | 0.842 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.333453e-01 | 0.875 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.029034e-01 | 0.988 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.029034e-01 | 0.988 |
| R-HSA-77108 | Utilization of Ketone Bodies | 1.798845e-01 | 0.745 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.153531e-01 | 0.938 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.199759e-01 | 0.921 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.199759e-01 | 0.921 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.534848e-01 | 0.814 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.534848e-01 | 0.814 |
| R-HSA-9710421 | Defective pyroptosis | 1.633678e-01 | 0.787 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.783941e-01 | 0.749 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.834499e-01 | 0.736 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.062520e-01 | 0.974 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.534848e-01 | 0.814 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.838608e-01 | 0.736 |
| R-HSA-4086400 | PCP/CE pathway | 1.239045e-01 | 0.907 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.388984e-01 | 0.857 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.320598e-01 | 0.879 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.246440e-01 | 0.904 |
| R-HSA-4641257 | Degradation of AXIN | 1.293552e-01 | 0.888 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.293552e-01 | 0.888 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.062520e-01 | 0.974 |
| R-HSA-373752 | Netrin-1 signaling | 1.683514e-01 | 0.774 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 1.071163e-01 | 0.970 |
| R-HSA-164944 | Nef and signal transduction | 1.196760e-01 | 0.922 |
| R-HSA-447041 | CHL1 interactions | 1.320598e-01 | 0.879 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.563095e-01 | 0.806 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.107777e-01 | 0.956 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.153531e-01 | 0.938 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.153531e-01 | 0.938 |
| R-HSA-169911 | Regulation of Apoptosis | 1.199759e-01 | 0.921 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.534848e-01 | 0.814 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.534848e-01 | 0.814 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.987356e-01 | 0.702 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.496092e-01 | 0.825 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 1.386989e-01 | 0.858 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 1.386989e-01 | 0.858 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.313698e-01 | 0.882 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.803443e-01 | 0.744 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.437263e-01 | 0.842 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.485890e-01 | 0.828 |
| R-HSA-69206 | G1/S Transition | 1.388885e-01 | 0.857 |
| R-HSA-597592 | Post-translational protein modification | 1.535816e-01 | 0.814 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.338632e-01 | 0.873 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.388984e-01 | 0.857 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.633678e-01 | 0.787 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.733607e-01 | 0.761 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.365816e-01 | 0.865 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.320598e-01 | 0.879 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.733607e-01 | 0.761 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.423552e-01 | 0.847 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.437263e-01 | 0.842 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.485890e-01 | 0.828 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.733607e-01 | 0.761 |
| R-HSA-9748787 | Azathioprine ADME | 1.987356e-01 | 0.702 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.945174e-01 | 0.711 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.563095e-01 | 0.806 |
| R-HSA-9766229 | Degradation of CDH1 | 1.936222e-01 | 0.713 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.038651e-01 | 0.691 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.991874e-01 | 0.701 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.733607e-01 | 0.761 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.733607e-01 | 0.761 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.058103e-01 | 0.975 |
| R-HSA-202424 | Downstream TCR signaling | 1.664718e-01 | 0.779 |
| R-HSA-69541 | Stabilization of p53 | 1.388984e-01 | 0.857 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.038651e-01 | 0.691 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.333453e-01 | 0.875 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.388984e-01 | 0.857 |
| R-HSA-9824272 | Somitogenesis | 1.733607e-01 | 0.761 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.485890e-01 | 0.828 |
| R-HSA-9679506 | SARS-CoV Infections | 1.963485e-01 | 0.707 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.246440e-01 | 0.904 |
| R-HSA-75153 | Apoptotic execution phase | 1.783941e-01 | 0.749 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.791522e-01 | 0.747 |
| R-HSA-5357801 | Programmed Cell Death | 1.023426e-01 | 0.990 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.044371e-01 | 0.689 |
| R-HSA-168249 | Innate Immune System | 2.058086e-01 | 0.687 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.090094e-01 | 0.680 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.090094e-01 | 0.680 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.090094e-01 | 0.680 |
| R-HSA-69242 | S Phase | 2.102715e-01 | 0.677 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.140229e-01 | 0.670 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.140229e-01 | 0.670 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.140229e-01 | 0.670 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.140229e-01 | 0.670 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.140229e-01 | 0.670 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.140229e-01 | 0.670 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.141670e-01 | 0.669 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.141670e-01 | 0.669 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.141670e-01 | 0.669 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.145690e-01 | 0.668 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.161531e-01 | 0.665 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.162627e-01 | 0.665 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.162627e-01 | 0.665 |
| R-HSA-72649 | Translation initiation complex formation | 2.193365e-01 | 0.659 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.193365e-01 | 0.659 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.193365e-01 | 0.659 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.220795e-01 | 0.653 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.245165e-01 | 0.649 |
| R-HSA-69306 | DNA Replication | 2.250589e-01 | 0.648 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.250850e-01 | 0.648 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.250850e-01 | 0.648 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.273222e-01 | 0.643 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.273222e-01 | 0.643 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.297058e-01 | 0.639 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.297058e-01 | 0.639 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.349031e-01 | 0.629 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.349031e-01 | 0.629 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.359920e-01 | 0.627 |
| R-HSA-9857492 | Protein lipoylation | 2.359920e-01 | 0.627 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.359920e-01 | 0.627 |
| R-HSA-8876725 | Protein methylation | 2.359920e-01 | 0.627 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.359920e-01 | 0.627 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.401071e-01 | 0.620 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.459827e-01 | 0.609 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.467462e-01 | 0.608 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.467462e-01 | 0.608 |
| R-HSA-9664420 | Killing mechanisms | 2.467462e-01 | 0.608 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.467462e-01 | 0.608 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.467462e-01 | 0.608 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.505304e-01 | 0.601 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.505304e-01 | 0.601 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.505304e-01 | 0.601 |
| R-HSA-351202 | Metabolism of polyamines | 2.505304e-01 | 0.601 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.557474e-01 | 0.592 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.573497e-01 | 0.589 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.573497e-01 | 0.589 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.573497e-01 | 0.589 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.573497e-01 | 0.589 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.573497e-01 | 0.589 |
| R-HSA-6783984 | Glycine degradation | 2.573497e-01 | 0.589 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.573497e-01 | 0.589 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.609666e-01 | 0.583 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.609666e-01 | 0.583 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.609666e-01 | 0.583 |
| R-HSA-186797 | Signaling by PDGF | 2.609666e-01 | 0.583 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.678045e-01 | 0.572 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.678045e-01 | 0.572 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.678045e-01 | 0.572 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.678045e-01 | 0.572 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.678045e-01 | 0.572 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.678045e-01 | 0.572 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.699608e-01 | 0.569 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.706073e-01 | 0.568 |
| R-HSA-162906 | HIV Infection | 2.732929e-01 | 0.563 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.762936e-01 | 0.559 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.766257e-01 | 0.558 |
| R-HSA-180292 | GAB1 signalosome | 2.781128e-01 | 0.556 |
| R-HSA-3928664 | Ephrin signaling | 2.781128e-01 | 0.556 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.781128e-01 | 0.556 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.781128e-01 | 0.556 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.781128e-01 | 0.556 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.781128e-01 | 0.556 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.781128e-01 | 0.556 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.818425e-01 | 0.550 |
| R-HSA-418555 | G alpha (s) signalling events | 2.833355e-01 | 0.548 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.839348e-01 | 0.547 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.882766e-01 | 0.540 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.882766e-01 | 0.540 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.882766e-01 | 0.540 |
| R-HSA-392517 | Rap1 signalling | 2.882766e-01 | 0.540 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.882766e-01 | 0.540 |
| R-HSA-449836 | Other interleukin signaling | 2.882766e-01 | 0.540 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.896135e-01 | 0.538 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.896135e-01 | 0.538 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.922662e-01 | 0.534 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.927599e-01 | 0.533 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.928207e-01 | 0.533 |
| R-HSA-195721 | Signaling by WNT | 2.966410e-01 | 0.528 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.974711e-01 | 0.527 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.982979e-01 | 0.525 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.982979e-01 | 0.525 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.982979e-01 | 0.525 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.982979e-01 | 0.525 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.982979e-01 | 0.525 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.982979e-01 | 0.525 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 2.982979e-01 | 0.525 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.026702e-01 | 0.519 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.026702e-01 | 0.519 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.026702e-01 | 0.519 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.026702e-01 | 0.519 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.078627e-01 | 0.512 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.081788e-01 | 0.511 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.081788e-01 | 0.511 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.081788e-01 | 0.511 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.081788e-01 | 0.511 |
| R-HSA-198753 | ERK/MAPK targets | 3.081788e-01 | 0.511 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.130476e-01 | 0.504 |
| R-HSA-2022870 | CS-GAG biosynthesis | 3.179211e-01 | 0.498 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.179211e-01 | 0.498 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.179211e-01 | 0.498 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.179211e-01 | 0.498 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.179211e-01 | 0.498 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.182243e-01 | 0.497 |
| R-HSA-194138 | Signaling by VEGF | 3.184937e-01 | 0.497 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.233918e-01 | 0.490 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.233918e-01 | 0.490 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.275267e-01 | 0.485 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.275267e-01 | 0.485 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.275267e-01 | 0.485 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.275267e-01 | 0.485 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 3.275267e-01 | 0.485 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.275267e-01 | 0.485 |
| R-HSA-8964038 | LDL clearance | 3.275267e-01 | 0.485 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.285495e-01 | 0.483 |
| R-HSA-5689603 | UCH proteinases | 3.336966e-01 | 0.477 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.336966e-01 | 0.477 |
| R-HSA-74182 | Ketone body metabolism | 3.369978e-01 | 0.472 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 3.369978e-01 | 0.472 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.369978e-01 | 0.472 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.369978e-01 | 0.472 |
| R-HSA-5619084 | ABC transporter disorders | 3.439560e-01 | 0.463 |
| R-HSA-9843745 | Adipogenesis | 3.454303e-01 | 0.462 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.463359e-01 | 0.461 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.463359e-01 | 0.461 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.463359e-01 | 0.461 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.463359e-01 | 0.461 |
| R-HSA-429947 | Deadenylation of mRNA | 3.463359e-01 | 0.461 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.463359e-01 | 0.461 |
| R-HSA-9909396 | Circadian clock | 3.492737e-01 | 0.457 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.499498e-01 | 0.456 |
| R-HSA-6806834 | Signaling by MET | 3.541647e-01 | 0.451 |
| R-HSA-1296059 | G protein gated Potassium channels | 3.555432e-01 | 0.449 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3.555432e-01 | 0.449 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 3.555432e-01 | 0.449 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.555432e-01 | 0.449 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.555432e-01 | 0.449 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.555432e-01 | 0.449 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.585960e-01 | 0.445 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.627226e-01 | 0.440 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.646213e-01 | 0.438 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.646213e-01 | 0.438 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.646213e-01 | 0.438 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.646213e-01 | 0.438 |
| R-HSA-525793 | Myogenesis | 3.646213e-01 | 0.438 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.646213e-01 | 0.438 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.684499e-01 | 0.434 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.684499e-01 | 0.434 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.693713e-01 | 0.433 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.735721e-01 | 0.428 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.735721e-01 | 0.428 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.744095e-01 | 0.427 |
| R-HSA-1500620 | Meiosis | 3.794312e-01 | 0.421 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.794312e-01 | 0.421 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.794312e-01 | 0.421 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.837217e-01 | 0.416 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.837217e-01 | 0.416 |
| R-HSA-9664407 | Parasite infection | 3.837217e-01 | 0.416 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.850492e-01 | 0.414 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.875274e-01 | 0.412 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.894237e-01 | 0.410 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.894237e-01 | 0.410 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.910987e-01 | 0.408 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.910987e-01 | 0.408 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.910987e-01 | 0.408 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.943934e-01 | 0.404 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.989101e-01 | 0.399 |
| R-HSA-156902 | Peptide chain elongation | 3.993447e-01 | 0.399 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.993447e-01 | 0.399 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.996781e-01 | 0.398 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.996781e-01 | 0.398 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.996781e-01 | 0.398 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.042771e-01 | 0.393 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.081371e-01 | 0.389 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.081371e-01 | 0.389 |
| R-HSA-182971 | EGFR downregulation | 4.081371e-01 | 0.389 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.081371e-01 | 0.389 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.081371e-01 | 0.389 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.081371e-01 | 0.389 |
| R-HSA-73884 | Base Excision Repair | 4.091903e-01 | 0.388 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.140838e-01 | 0.383 |
| R-HSA-446728 | Cell junction organization | 4.143253e-01 | 0.383 |
| R-HSA-1538133 | G0 and Early G1 | 4.164775e-01 | 0.380 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 4.164775e-01 | 0.380 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.164775e-01 | 0.380 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.164775e-01 | 0.380 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.189571e-01 | 0.378 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.189571e-01 | 0.378 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.238100e-01 | 0.373 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.247008e-01 | 0.372 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.247008e-01 | 0.372 |
| R-HSA-354192 | Integrin signaling | 4.247008e-01 | 0.372 |
| R-HSA-9930044 | Nuclear RNA decay | 4.247008e-01 | 0.372 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.247008e-01 | 0.372 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.247008e-01 | 0.372 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.328087e-01 | 0.364 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.328087e-01 | 0.364 |
| R-HSA-2024101 | CS/DS degradation | 4.328087e-01 | 0.364 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.328087e-01 | 0.364 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.328087e-01 | 0.364 |
| R-HSA-418990 | Adherens junctions interactions | 4.356332e-01 | 0.361 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.382414e-01 | 0.358 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 4.408029e-01 | 0.356 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.408029e-01 | 0.356 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.408029e-01 | 0.356 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.408029e-01 | 0.356 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.408029e-01 | 0.356 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.408029e-01 | 0.356 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.430084e-01 | 0.354 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.430084e-01 | 0.354 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.430084e-01 | 0.354 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.437924e-01 | 0.353 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.486848e-01 | 0.348 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.548164e-01 | 0.342 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.564562e-01 | 0.341 |
| R-HSA-111933 | Calmodulin induced events | 4.564562e-01 | 0.341 |
| R-HSA-111997 | CaM pathway | 4.564562e-01 | 0.341 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.564562e-01 | 0.341 |
| R-HSA-877300 | Interferon gamma signaling | 4.584711e-01 | 0.339 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.641185e-01 | 0.333 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.641185e-01 | 0.333 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.641185e-01 | 0.333 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.641185e-01 | 0.333 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.665023e-01 | 0.331 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.711308e-01 | 0.327 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.716732e-01 | 0.326 |
| R-HSA-71336 | Pentose phosphate pathway | 4.791219e-01 | 0.320 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.791219e-01 | 0.320 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.791219e-01 | 0.320 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.791219e-01 | 0.320 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.791219e-01 | 0.320 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.791219e-01 | 0.320 |
| R-HSA-192823 | Viral mRNA Translation | 4.803156e-01 | 0.318 |
| R-HSA-392499 | Metabolism of proteins | 4.844524e-01 | 0.315 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.848714e-01 | 0.314 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.850154e-01 | 0.314 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.864660e-01 | 0.313 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.864660e-01 | 0.313 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 4.864660e-01 | 0.313 |
| R-HSA-9833110 | RSV-host interactions | 4.894024e-01 | 0.310 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 4.894024e-01 | 0.310 |
| R-HSA-15869 | Metabolism of nucleotides | 4.910727e-01 | 0.309 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.937071e-01 | 0.307 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.937071e-01 | 0.307 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.937071e-01 | 0.307 |
| R-HSA-9607240 | FLT3 Signaling | 4.937071e-01 | 0.307 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.008464e-01 | 0.300 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.008464e-01 | 0.300 |
| R-HSA-72306 | tRNA processing | 5.014675e-01 | 0.300 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.028453e-01 | 0.299 |
| R-HSA-69239 | Synthesis of DNA | 5.028453e-01 | 0.299 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.049734e-01 | 0.297 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.072755e-01 | 0.295 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.072755e-01 | 0.295 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.072755e-01 | 0.295 |
| R-HSA-165159 | MTOR signalling | 5.078856e-01 | 0.294 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.078856e-01 | 0.294 |
| R-HSA-73928 | Depyrimidination | 5.078856e-01 | 0.294 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.078856e-01 | 0.294 |
| R-HSA-111996 | Ca-dependent events | 5.078856e-01 | 0.294 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.078856e-01 | 0.294 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.148258e-01 | 0.288 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.216687e-01 | 0.283 |
| R-HSA-69236 | G1 Phase | 5.216687e-01 | 0.283 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.216687e-01 | 0.283 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.247384e-01 | 0.280 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.247384e-01 | 0.280 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.247384e-01 | 0.280 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.284154e-01 | 0.277 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.284154e-01 | 0.277 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.284154e-01 | 0.277 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.284154e-01 | 0.277 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.284154e-01 | 0.277 |
| R-HSA-4839726 | Chromatin organization | 5.296916e-01 | 0.276 |
| R-HSA-168255 | Influenza Infection | 5.325529e-01 | 0.274 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.350674e-01 | 0.272 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.350674e-01 | 0.272 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.350674e-01 | 0.272 |
| R-HSA-421270 | Cell-cell junction organization | 5.355076e-01 | 0.271 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.416260e-01 | 0.266 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.417818e-01 | 0.266 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.459763e-01 | 0.263 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.480924e-01 | 0.261 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.501441e-01 | 0.260 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.501441e-01 | 0.260 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 5.533770e-01 | 0.257 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.544681e-01 | 0.256 |
| R-HSA-73893 | DNA Damage Bypass | 5.544681e-01 | 0.256 |
| R-HSA-418594 | G alpha (i) signalling events | 5.661807e-01 | 0.247 |
| R-HSA-68875 | Mitotic Prophase | 5.665461e-01 | 0.247 |
| R-HSA-912446 | Meiotic recombination | 5.669519e-01 | 0.246 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 5.669519e-01 | 0.246 |
| R-HSA-73886 | Chromosome Maintenance | 5.705791e-01 | 0.244 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.730626e-01 | 0.242 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.730626e-01 | 0.242 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.785637e-01 | 0.238 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.790874e-01 | 0.237 |
| R-HSA-1221632 | Meiotic synapsis | 5.790874e-01 | 0.237 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.790874e-01 | 0.237 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.825152e-01 | 0.235 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.850276e-01 | 0.233 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.903366e-01 | 0.229 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.903366e-01 | 0.229 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.903366e-01 | 0.229 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 5.908843e-01 | 0.228 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.908843e-01 | 0.228 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.966587e-01 | 0.224 |
| R-HSA-177929 | Signaling by EGFR | 5.966587e-01 | 0.224 |
| R-HSA-8935690 | Digestion | 5.966587e-01 | 0.224 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.966587e-01 | 0.224 |
| R-HSA-1483166 | Synthesis of PA | 6.023519e-01 | 0.220 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.079652e-01 | 0.216 |
| R-HSA-1474165 | Reproduction | 6.131470e-01 | 0.212 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.134995e-01 | 0.212 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.134995e-01 | 0.212 |
| R-HSA-191859 | snRNP Assembly | 6.134995e-01 | 0.212 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.134995e-01 | 0.212 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.206995e-01 | 0.207 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.243359e-01 | 0.205 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.243359e-01 | 0.205 |
| R-HSA-112043 | PLC beta mediated events | 6.243359e-01 | 0.205 |
| R-HSA-9707616 | Heme signaling | 6.296401e-01 | 0.201 |
| R-HSA-6799198 | Complex I biogenesis | 6.348698e-01 | 0.197 |
| R-HSA-373755 | Semaphorin interactions | 6.348698e-01 | 0.197 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.348698e-01 | 0.197 |
| R-HSA-8963743 | Digestion and absorption | 6.348698e-01 | 0.197 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.400259e-01 | 0.194 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.400259e-01 | 0.194 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.422774e-01 | 0.192 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.451096e-01 | 0.190 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.489923e-01 | 0.188 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.501217e-01 | 0.187 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.550634e-01 | 0.184 |
| R-HSA-196807 | Nicotinate metabolism | 6.550634e-01 | 0.184 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.599356e-01 | 0.180 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.625779e-01 | 0.179 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.625779e-01 | 0.179 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.692114e-01 | 0.174 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.741448e-01 | 0.171 |
| R-HSA-3000178 | ECM proteoglycans | 6.741448e-01 | 0.171 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.741448e-01 | 0.171 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.787486e-01 | 0.168 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.787486e-01 | 0.168 |
| R-HSA-9758941 | Gastrulation | 6.853358e-01 | 0.164 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.884826e-01 | 0.162 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.921750e-01 | 0.160 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.921750e-01 | 0.160 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.921750e-01 | 0.160 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.933658e-01 | 0.159 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.946990e-01 | 0.158 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.008131e-01 | 0.154 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.008141e-01 | 0.154 |
| R-HSA-216083 | Integrin cell surface interactions | 7.050426e-01 | 0.152 |
| R-HSA-9659379 | Sensory processing of sound | 7.092117e-01 | 0.149 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.092117e-01 | 0.149 |
| R-HSA-9610379 | HCMV Late Events | 7.097940e-01 | 0.149 |
| R-HSA-162587 | HIV Life Cycle | 7.097940e-01 | 0.149 |
| R-HSA-9711097 | Cellular response to starvation | 7.127374e-01 | 0.147 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.133221e-01 | 0.147 |
| R-HSA-157118 | Signaling by NOTCH | 7.137233e-01 | 0.146 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.213701e-01 | 0.142 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.253094e-01 | 0.139 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.298783e-01 | 0.137 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.303495e-01 | 0.136 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.367976e-01 | 0.133 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.405197e-01 | 0.130 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 7.478073e-01 | 0.126 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.487763e-01 | 0.126 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.651472e-01 | 0.116 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.651472e-01 | 0.116 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.651472e-01 | 0.116 |
| R-HSA-2029481 | FCGR activation | 7.684700e-01 | 0.114 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.684700e-01 | 0.114 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.749759e-01 | 0.111 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.812997e-01 | 0.107 |
| R-HSA-1296071 | Potassium Channels | 7.812997e-01 | 0.107 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.843949e-01 | 0.105 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.874466e-01 | 0.104 |
| R-HSA-3214847 | HATs acetylate histones | 7.904552e-01 | 0.102 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.904552e-01 | 0.102 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.922369e-01 | 0.101 |
| R-HSA-70171 | Glycolysis | 7.934214e-01 | 0.100 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.048740e-01 | 0.094 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.103610e-01 | 0.091 |
| R-HSA-211000 | Gene Silencing by RNA | 8.156944e-01 | 0.088 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.183048e-01 | 0.087 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.234157e-01 | 0.084 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.255475e-01 | 0.083 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.283834e-01 | 0.082 |
| R-HSA-6805567 | Keratinization | 8.308078e-01 | 0.080 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.355753e-01 | 0.078 |
| R-HSA-397014 | Muscle contraction | 8.415816e-01 | 0.075 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.446998e-01 | 0.073 |
| R-HSA-70326 | Glucose metabolism | 8.446998e-01 | 0.073 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.446998e-01 | 0.073 |
| R-HSA-9748784 | Drug ADME | 8.517324e-01 | 0.070 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.574498e-01 | 0.067 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.653653e-01 | 0.063 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.691573e-01 | 0.061 |
| R-HSA-72312 | rRNA processing | 8.731589e-01 | 0.059 |
| R-HSA-9717189 | Sensory perception of taste | 8.764253e-01 | 0.057 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.764253e-01 | 0.057 |
| R-HSA-72766 | Translation | 8.824903e-01 | 0.054 |
| R-HSA-166520 | Signaling by NTRKs | 9.058219e-01 | 0.043 |
| R-HSA-416476 | G alpha (q) signalling events | 9.118811e-01 | 0.040 |
| R-HSA-1989781 | PPARA activates gene expression | 9.147983e-01 | 0.039 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.172028e-01 | 0.038 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.172028e-01 | 0.038 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.206835e-01 | 0.036 |
| R-HSA-5619102 | SLC transporter disorders | 9.282488e-01 | 0.032 |
| R-HSA-388396 | GPCR downstream signalling | 9.360777e-01 | 0.029 |
| R-HSA-611105 | Respiratory electron transport | 9.395837e-01 | 0.027 |
| R-HSA-3781865 | Diseases of glycosylation | 9.445635e-01 | 0.025 |
| R-HSA-983712 | Ion channel transport | 9.483997e-01 | 0.023 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.512773e-01 | 0.022 |
| R-HSA-8957322 | Metabolism of steroids | 9.565224e-01 | 0.019 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.577915e-01 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 9.600303e-01 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.645760e-01 | 0.016 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.658470e-01 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 9.676131e-01 | 0.014 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.713642e-01 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.717730e-01 | 0.012 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.744770e-01 | 0.011 |
| R-HSA-5668914 | Diseases of metabolism | 9.879040e-01 | 0.005 |
| R-HSA-1483257 | Phospholipid metabolism | 9.889380e-01 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.959250e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.996956e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.998500e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999995e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999996e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.864 | 0.172 | 2 | 0.809 |
DSTYK |
0.849 | 0.079 | 2 | 0.812 |
GCN2 |
0.849 | -0.033 | 2 | 0.771 |
CDC7 |
0.848 | -0.014 | 1 | 0.742 |
CHAK2 |
0.847 | 0.150 | -1 | 0.901 |
ULK2 |
0.847 | -0.005 | 2 | 0.756 |
NEK6 |
0.846 | 0.075 | -2 | 0.849 |
PRPK |
0.846 | -0.098 | -1 | 0.844 |
CLK3 |
0.846 | 0.125 | 1 | 0.763 |
MTOR |
0.845 | -0.033 | 1 | 0.729 |
MOS |
0.845 | 0.015 | 1 | 0.794 |
IKKB |
0.843 | -0.046 | -2 | 0.756 |
ERK5 |
0.842 | 0.047 | 1 | 0.770 |
NLK |
0.841 | 0.010 | 1 | 0.790 |
NEK7 |
0.841 | -0.005 | -3 | 0.830 |
RAF1 |
0.841 | -0.090 | 1 | 0.788 |
BMPR2 |
0.840 | -0.074 | -2 | 0.879 |
PIM3 |
0.840 | 0.021 | -3 | 0.718 |
TBK1 |
0.840 | -0.091 | 1 | 0.693 |
PDHK4 |
0.840 | -0.230 | 1 | 0.798 |
PRKD1 |
0.840 | 0.034 | -3 | 0.697 |
HIPK4 |
0.839 | 0.058 | 1 | 0.799 |
CAMK2G |
0.839 | -0.062 | 2 | 0.770 |
RIPK3 |
0.838 | -0.031 | 3 | 0.708 |
MLK1 |
0.838 | -0.025 | 2 | 0.749 |
WNK1 |
0.838 | 0.015 | -2 | 0.888 |
CDKL1 |
0.838 | -0.011 | -3 | 0.705 |
ULK1 |
0.838 | -0.068 | -3 | 0.801 |
CAMK1B |
0.838 | -0.069 | -3 | 0.775 |
KIS |
0.838 | 0.030 | 1 | 0.655 |
SKMLCK |
0.838 | 0.036 | -2 | 0.849 |
IKKA |
0.837 | 0.034 | -2 | 0.745 |
ATR |
0.836 | -0.067 | 1 | 0.768 |
IKKE |
0.836 | -0.109 | 1 | 0.687 |
PRKD2 |
0.836 | 0.033 | -3 | 0.632 |
MST4 |
0.835 | 0.023 | 2 | 0.744 |
NDR2 |
0.835 | -0.036 | -3 | 0.714 |
PDHK1 |
0.835 | -0.192 | 1 | 0.794 |
GRK5 |
0.834 | -0.083 | -3 | 0.831 |
GRK1 |
0.834 | 0.065 | -2 | 0.755 |
NEK9 |
0.834 | -0.016 | 2 | 0.786 |
CDK8 |
0.834 | 0.024 | 1 | 0.648 |
TGFBR2 |
0.833 | -0.043 | -2 | 0.770 |
CDKL5 |
0.832 | -0.005 | -3 | 0.692 |
PKN3 |
0.832 | -0.062 | -3 | 0.725 |
SRPK1 |
0.831 | 0.009 | -3 | 0.630 |
NIK |
0.831 | -0.101 | -3 | 0.802 |
IRE1 |
0.831 | 0.004 | 1 | 0.824 |
PKCD |
0.831 | 0.018 | 2 | 0.725 |
RSK2 |
0.831 | -0.014 | -3 | 0.652 |
GRK6 |
0.830 | -0.019 | 1 | 0.771 |
HUNK |
0.829 | -0.096 | 2 | 0.802 |
MLK2 |
0.829 | -0.033 | 2 | 0.766 |
PKN2 |
0.829 | -0.048 | -3 | 0.737 |
CAMLCK |
0.829 | -0.068 | -2 | 0.842 |
NDR1 |
0.829 | -0.064 | -3 | 0.718 |
PIM1 |
0.829 | 0.025 | -3 | 0.662 |
TSSK2 |
0.829 | -0.009 | -5 | 0.840 |
MLK3 |
0.829 | 0.021 | 2 | 0.680 |
PKR |
0.828 | 0.122 | 1 | 0.845 |
CDK19 |
0.828 | 0.022 | 1 | 0.612 |
MASTL |
0.828 | -0.174 | -2 | 0.806 |
ICK |
0.828 | -0.012 | -3 | 0.733 |
DYRK2 |
0.828 | 0.038 | 1 | 0.702 |
RIPK1 |
0.828 | -0.097 | 1 | 0.816 |
CAMK2D |
0.827 | -0.061 | -3 | 0.748 |
WNK3 |
0.827 | -0.186 | 1 | 0.792 |
BCKDK |
0.827 | -0.136 | -1 | 0.820 |
ANKRD3 |
0.827 | -0.077 | 1 | 0.836 |
BMPR1B |
0.827 | 0.097 | 1 | 0.734 |
DAPK2 |
0.827 | -0.088 | -3 | 0.782 |
NUAK2 |
0.827 | -0.077 | -3 | 0.730 |
AMPKA1 |
0.827 | -0.057 | -3 | 0.743 |
MAPKAPK3 |
0.826 | -0.063 | -3 | 0.646 |
NIM1 |
0.826 | -0.058 | 3 | 0.710 |
GRK4 |
0.826 | -0.081 | -2 | 0.802 |
P90RSK |
0.826 | -0.061 | -3 | 0.655 |
ALK4 |
0.826 | 0.025 | -2 | 0.823 |
CDK1 |
0.826 | 0.066 | 1 | 0.593 |
TGFBR1 |
0.825 | 0.053 | -2 | 0.792 |
AURC |
0.825 | 0.037 | -2 | 0.643 |
PAK6 |
0.825 | 0.087 | -2 | 0.694 |
TSSK1 |
0.825 | -0.012 | -3 | 0.758 |
MNK2 |
0.825 | 0.021 | -2 | 0.786 |
MARK4 |
0.825 | -0.091 | 4 | 0.778 |
PLK1 |
0.825 | -0.031 | -2 | 0.784 |
LATS2 |
0.824 | -0.048 | -5 | 0.694 |
DLK |
0.824 | -0.127 | 1 | 0.799 |
PKACG |
0.824 | -0.028 | -2 | 0.726 |
FAM20C |
0.824 | 0.001 | 2 | 0.518 |
MPSK1 |
0.823 | 0.233 | 1 | 0.868 |
CDK5 |
0.823 | 0.053 | 1 | 0.662 |
CHAK1 |
0.823 | 0.005 | 2 | 0.747 |
NEK2 |
0.823 | -0.022 | 2 | 0.766 |
TTBK2 |
0.823 | -0.126 | 2 | 0.696 |
RSK3 |
0.823 | -0.063 | -3 | 0.648 |
MLK4 |
0.822 | -0.008 | 2 | 0.664 |
JNK2 |
0.822 | 0.060 | 1 | 0.576 |
PAK1 |
0.821 | -0.038 | -2 | 0.769 |
PKCZ |
0.821 | 0.018 | 2 | 0.730 |
PKCA |
0.821 | 0.000 | 2 | 0.668 |
P38A |
0.821 | 0.041 | 1 | 0.678 |
VRK2 |
0.821 | -0.022 | 1 | 0.852 |
PKCB |
0.821 | -0.004 | 2 | 0.679 |
MAPKAPK2 |
0.821 | -0.044 | -3 | 0.593 |
IRE2 |
0.821 | -0.060 | 2 | 0.720 |
JNK3 |
0.820 | 0.037 | 1 | 0.604 |
P70S6KB |
0.820 | -0.079 | -3 | 0.686 |
CDK18 |
0.820 | 0.024 | 1 | 0.579 |
CDK7 |
0.819 | -0.023 | 1 | 0.639 |
ATM |
0.819 | -0.076 | 1 | 0.689 |
CDK2 |
0.819 | 0.048 | 1 | 0.673 |
AMPKA2 |
0.819 | -0.072 | -3 | 0.699 |
CAMK2B |
0.819 | -0.035 | 2 | 0.727 |
SRPK2 |
0.819 | -0.033 | -3 | 0.556 |
TLK2 |
0.819 | -0.022 | 1 | 0.783 |
PKCG |
0.818 | -0.035 | 2 | 0.681 |
MEK1 |
0.818 | -0.111 | 2 | 0.809 |
ERK1 |
0.818 | 0.026 | 1 | 0.591 |
CDK3 |
0.818 | 0.101 | 1 | 0.536 |
PAK3 |
0.818 | -0.087 | -2 | 0.768 |
CLK4 |
0.818 | 0.000 | -3 | 0.652 |
CDK13 |
0.817 | -0.023 | 1 | 0.608 |
CLK1 |
0.817 | 0.017 | -3 | 0.625 |
PINK1 |
0.817 | -0.010 | 1 | 0.848 |
P38B |
0.817 | 0.042 | 1 | 0.592 |
PRKD3 |
0.817 | -0.052 | -3 | 0.614 |
GRK7 |
0.817 | 0.024 | 1 | 0.694 |
IRAK4 |
0.817 | 0.028 | 1 | 0.821 |
YSK4 |
0.816 | -0.104 | 1 | 0.739 |
SMG1 |
0.816 | -0.085 | 1 | 0.725 |
PKCH |
0.816 | -0.049 | 2 | 0.683 |
PRP4 |
0.815 | 0.057 | -3 | 0.748 |
LATS1 |
0.815 | -0.025 | -3 | 0.728 |
CAMK4 |
0.815 | -0.162 | -3 | 0.716 |
PLK4 |
0.815 | -0.067 | 2 | 0.667 |
MNK1 |
0.815 | -0.012 | -2 | 0.796 |
ACVR2A |
0.814 | -0.013 | -2 | 0.771 |
P38G |
0.814 | 0.030 | 1 | 0.512 |
ACVR2B |
0.814 | -0.011 | -2 | 0.781 |
NEK5 |
0.814 | 0.042 | 1 | 0.823 |
MELK |
0.814 | -0.097 | -3 | 0.687 |
PERK |
0.814 | -0.034 | -2 | 0.820 |
HIPK2 |
0.814 | 0.029 | 1 | 0.618 |
AURB |
0.814 | -0.014 | -2 | 0.638 |
CAMK2A |
0.814 | -0.052 | 2 | 0.748 |
PLK3 |
0.813 | -0.061 | 2 | 0.745 |
ZAK |
0.813 | -0.029 | 1 | 0.768 |
MSK2 |
0.813 | -0.101 | -3 | 0.624 |
HIPK1 |
0.813 | 0.018 | 1 | 0.725 |
MEKK3 |
0.813 | -0.074 | 1 | 0.784 |
GAK |
0.813 | 0.250 | 1 | 0.876 |
P38D |
0.813 | 0.061 | 1 | 0.532 |
ALK2 |
0.813 | -0.009 | -2 | 0.795 |
SRPK3 |
0.813 | -0.065 | -3 | 0.615 |
NUAK1 |
0.812 | -0.109 | -3 | 0.671 |
MEKK1 |
0.812 | -0.048 | 1 | 0.801 |
RSK4 |
0.812 | -0.031 | -3 | 0.609 |
MEKK2 |
0.812 | -0.007 | 2 | 0.764 |
ERK2 |
0.812 | -0.014 | 1 | 0.628 |
BRAF |
0.812 | -0.029 | -4 | 0.822 |
CDK17 |
0.811 | -0.003 | 1 | 0.517 |
CK1E |
0.811 | 0.004 | -3 | 0.550 |
DNAPK |
0.811 | -0.048 | 1 | 0.616 |
PKG2 |
0.811 | -0.017 | -2 | 0.668 |
CHK1 |
0.811 | -0.062 | -3 | 0.716 |
WNK4 |
0.811 | -0.050 | -2 | 0.884 |
PAK2 |
0.811 | -0.102 | -2 | 0.751 |
SGK3 |
0.810 | -0.029 | -3 | 0.642 |
HRI |
0.810 | -0.121 | -2 | 0.835 |
PKACB |
0.810 | -0.008 | -2 | 0.657 |
QIK |
0.810 | -0.167 | -3 | 0.748 |
BMPR1A |
0.810 | 0.053 | 1 | 0.707 |
GRK2 |
0.810 | -0.043 | -2 | 0.705 |
MSK1 |
0.809 | -0.056 | -3 | 0.626 |
PRKX |
0.809 | 0.030 | -3 | 0.535 |
QSK |
0.809 | -0.099 | 4 | 0.748 |
PHKG1 |
0.808 | -0.145 | -3 | 0.710 |
MST3 |
0.808 | 0.010 | 2 | 0.763 |
AKT2 |
0.808 | -0.032 | -3 | 0.564 |
CDK12 |
0.808 | -0.035 | 1 | 0.579 |
CLK2 |
0.807 | 0.034 | -3 | 0.621 |
LKB1 |
0.807 | 0.075 | -3 | 0.800 |
MEK5 |
0.806 | -0.199 | 2 | 0.783 |
MYLK4 |
0.806 | -0.098 | -2 | 0.752 |
DCAMKL1 |
0.806 | -0.058 | -3 | 0.650 |
DYRK1A |
0.806 | -0.038 | 1 | 0.700 |
AURA |
0.806 | -0.038 | -2 | 0.603 |
TLK1 |
0.805 | -0.105 | -2 | 0.804 |
CDK9 |
0.805 | -0.056 | 1 | 0.617 |
HIPK3 |
0.805 | -0.033 | 1 | 0.709 |
CAMKK1 |
0.805 | -0.010 | -2 | 0.776 |
DYRK4 |
0.805 | 0.002 | 1 | 0.610 |
DRAK1 |
0.804 | -0.100 | 1 | 0.711 |
CDK14 |
0.804 | -0.008 | 1 | 0.625 |
DYRK3 |
0.804 | -0.002 | 1 | 0.742 |
SIK |
0.804 | -0.126 | -3 | 0.640 |
MAPKAPK5 |
0.803 | -0.165 | -3 | 0.619 |
TAO3 |
0.803 | -0.028 | 1 | 0.761 |
PKCT |
0.802 | -0.064 | 2 | 0.687 |
CAMK1G |
0.802 | -0.103 | -3 | 0.653 |
SNRK |
0.802 | -0.240 | 2 | 0.692 |
GSK3B |
0.802 | 0.000 | 4 | 0.477 |
CK1G1 |
0.802 | -0.032 | -3 | 0.535 |
PIM2 |
0.802 | -0.056 | -3 | 0.631 |
MARK3 |
0.802 | -0.111 | 4 | 0.704 |
CDK16 |
0.802 | 0.011 | 1 | 0.534 |
BRSK2 |
0.801 | -0.184 | -3 | 0.706 |
IRAK1 |
0.801 | -0.153 | -1 | 0.763 |
TTBK1 |
0.801 | -0.143 | 2 | 0.616 |
SMMLCK |
0.801 | -0.091 | -3 | 0.723 |
DYRK1B |
0.800 | -0.023 | 1 | 0.639 |
GSK3A |
0.800 | 0.028 | 4 | 0.488 |
NEK11 |
0.800 | -0.124 | 1 | 0.751 |
PKCI |
0.800 | -0.050 | 2 | 0.687 |
MARK2 |
0.800 | -0.139 | 4 | 0.664 |
NEK8 |
0.799 | -0.104 | 2 | 0.767 |
CK1A2 |
0.799 | -0.009 | -3 | 0.498 |
DCAMKL2 |
0.799 | -0.102 | -3 | 0.686 |
NEK4 |
0.799 | -0.042 | 1 | 0.784 |
CK1D |
0.799 | -0.016 | -3 | 0.503 |
BRSK1 |
0.799 | -0.177 | -3 | 0.669 |
AKT1 |
0.799 | -0.032 | -3 | 0.576 |
CAMKK2 |
0.799 | -0.028 | -2 | 0.776 |
PAK5 |
0.798 | -0.021 | -2 | 0.610 |
PASK |
0.798 | -0.049 | -3 | 0.745 |
SSTK |
0.798 | -0.083 | 4 | 0.753 |
JNK1 |
0.797 | 0.008 | 1 | 0.555 |
PKCE |
0.797 | -0.013 | 2 | 0.668 |
TNIK |
0.796 | 0.042 | 3 | 0.816 |
EEF2K |
0.796 | -0.016 | 3 | 0.786 |
MINK |
0.796 | -0.002 | 1 | 0.775 |
PHKG2 |
0.796 | -0.134 | -3 | 0.686 |
MAP3K15 |
0.796 | -0.033 | 1 | 0.744 |
PAK4 |
0.796 | -0.002 | -2 | 0.616 |
CDK10 |
0.796 | -0.016 | 1 | 0.613 |
PKACA |
0.796 | -0.034 | -2 | 0.611 |
GRK3 |
0.795 | -0.043 | -2 | 0.654 |
PLK2 |
0.795 | 0.028 | -3 | 0.830 |
NEK1 |
0.795 | 0.013 | 1 | 0.799 |
ERK7 |
0.795 | -0.027 | 2 | 0.466 |
MST2 |
0.795 | -0.059 | 1 | 0.769 |
MARK1 |
0.795 | -0.169 | 4 | 0.731 |
HGK |
0.795 | -0.029 | 3 | 0.814 |
MEKK6 |
0.794 | -0.056 | 1 | 0.782 |
PDK1 |
0.794 | -0.095 | 1 | 0.751 |
GCK |
0.794 | -0.031 | 1 | 0.770 |
PBK |
0.794 | 0.161 | 1 | 0.826 |
CK2A2 |
0.794 | 0.008 | 1 | 0.628 |
VRK1 |
0.794 | 0.006 | 2 | 0.814 |
TAO2 |
0.793 | -0.117 | 2 | 0.788 |
CDK6 |
0.793 | -0.003 | 1 | 0.608 |
MAK |
0.793 | 0.056 | -2 | 0.764 |
BUB1 |
0.792 | 0.061 | -5 | 0.754 |
TAK1 |
0.792 | -0.057 | 1 | 0.789 |
CAMK1D |
0.790 | -0.098 | -3 | 0.560 |
P70S6K |
0.790 | -0.129 | -3 | 0.596 |
STK33 |
0.790 | -0.097 | 2 | 0.599 |
LRRK2 |
0.790 | -0.109 | 2 | 0.798 |
MOK |
0.788 | 0.032 | 1 | 0.761 |
PKN1 |
0.786 | -0.103 | -3 | 0.612 |
DAPK3 |
0.786 | -0.085 | -3 | 0.678 |
MST1 |
0.786 | -0.086 | 1 | 0.763 |
BIKE |
0.785 | 0.196 | 1 | 0.806 |
LOK |
0.785 | -0.089 | -2 | 0.758 |
ROCK2 |
0.785 | -0.002 | -3 | 0.664 |
CHK2 |
0.785 | -0.085 | -3 | 0.507 |
KHS1 |
0.785 | -0.032 | 1 | 0.749 |
HPK1 |
0.785 | -0.094 | 1 | 0.747 |
CDK4 |
0.784 | -0.035 | 1 | 0.571 |
CK2A1 |
0.784 | -0.004 | 1 | 0.607 |
MRCKB |
0.784 | -0.036 | -3 | 0.617 |
AKT3 |
0.784 | -0.040 | -3 | 0.491 |
YSK1 |
0.784 | -0.060 | 2 | 0.742 |
MRCKA |
0.784 | -0.047 | -3 | 0.637 |
KHS2 |
0.783 | -0.020 | 1 | 0.760 |
SGK1 |
0.782 | -0.050 | -3 | 0.481 |
NEK3 |
0.782 | -0.073 | 1 | 0.757 |
MEK2 |
0.782 | -0.181 | 2 | 0.795 |
RIPK2 |
0.781 | -0.239 | 1 | 0.714 |
TTK |
0.781 | 0.001 | -2 | 0.793 |
HASPIN |
0.780 | 0.019 | -1 | 0.735 |
DAPK1 |
0.779 | -0.096 | -3 | 0.665 |
PDHK3_TYR |
0.779 | 0.108 | 4 | 0.890 |
DMPK1 |
0.778 | -0.003 | -3 | 0.638 |
SLK |
0.778 | -0.109 | -2 | 0.694 |
CAMK1A |
0.777 | -0.099 | -3 | 0.518 |
OSR1 |
0.777 | -0.028 | 2 | 0.737 |
MYO3B |
0.777 | 0.007 | 2 | 0.760 |
SBK |
0.775 | -0.067 | -3 | 0.439 |
PKG1 |
0.772 | -0.068 | -2 | 0.593 |
AAK1 |
0.772 | 0.229 | 1 | 0.727 |
ASK1 |
0.771 | -0.094 | 1 | 0.723 |
PKMYT1_TYR |
0.771 | 0.003 | 3 | 0.808 |
MYO3A |
0.770 | -0.051 | 1 | 0.780 |
BMPR2_TYR |
0.770 | 0.019 | -1 | 0.858 |
MAP2K6_TYR |
0.769 | -0.025 | -1 | 0.872 |
ROCK1 |
0.769 | -0.044 | -3 | 0.634 |
TESK1_TYR |
0.769 | -0.101 | 3 | 0.825 |
MAP2K4_TYR |
0.769 | -0.077 | -1 | 0.865 |
PDHK4_TYR |
0.768 | -0.035 | 2 | 0.813 |
CK1A |
0.767 | -0.031 | -3 | 0.418 |
MAP2K7_TYR |
0.765 | -0.243 | 2 | 0.817 |
LIMK2_TYR |
0.765 | -0.029 | -3 | 0.824 |
PDHK1_TYR |
0.764 | -0.097 | -1 | 0.873 |
TAO1 |
0.763 | -0.127 | 1 | 0.701 |
YANK3 |
0.763 | -0.096 | 2 | 0.374 |
CRIK |
0.762 | -0.080 | -3 | 0.573 |
PINK1_TYR |
0.762 | -0.196 | 1 | 0.797 |
EPHA6 |
0.762 | -0.003 | -1 | 0.841 |
EPHB4 |
0.760 | -0.010 | -1 | 0.820 |
RET |
0.760 | -0.116 | 1 | 0.772 |
ALPHAK3 |
0.759 | -0.135 | -1 | 0.767 |
TYK2 |
0.759 | -0.118 | 1 | 0.768 |
LIMK1_TYR |
0.759 | -0.149 | 2 | 0.807 |
ABL2 |
0.759 | 0.026 | -1 | 0.777 |
CSF1R |
0.759 | -0.055 | 3 | 0.754 |
ROS1 |
0.758 | -0.089 | 3 | 0.739 |
JAK2 |
0.758 | -0.095 | 1 | 0.762 |
TYRO3 |
0.758 | -0.111 | 3 | 0.765 |
FGR |
0.757 | -0.012 | 1 | 0.835 |
MST1R |
0.757 | -0.137 | 3 | 0.769 |
ABL1 |
0.756 | 0.019 | -1 | 0.770 |
TXK |
0.756 | 0.057 | 1 | 0.781 |
YES1 |
0.756 | 0.000 | -1 | 0.798 |
STLK3 |
0.756 | -0.172 | 1 | 0.730 |
DDR1 |
0.756 | -0.140 | 4 | 0.818 |
TNK2 |
0.754 | -0.031 | 3 | 0.725 |
ITK |
0.753 | -0.004 | -1 | 0.763 |
FER |
0.753 | -0.103 | 1 | 0.790 |
HCK |
0.753 | -0.014 | -1 | 0.774 |
LCK |
0.753 | 0.052 | -1 | 0.775 |
TNNI3K_TYR |
0.752 | 0.007 | 1 | 0.830 |
JAK3 |
0.752 | -0.110 | 1 | 0.742 |
EPHB1 |
0.752 | -0.049 | 1 | 0.768 |
TNK1 |
0.752 | -0.053 | 3 | 0.744 |
EPHA4 |
0.751 | -0.057 | 2 | 0.730 |
EPHB3 |
0.751 | -0.040 | -1 | 0.802 |
PDGFRB |
0.751 | -0.120 | 3 | 0.768 |
SRMS |
0.751 | -0.061 | 1 | 0.774 |
EPHB2 |
0.751 | -0.020 | -1 | 0.793 |
INSRR |
0.750 | -0.116 | 3 | 0.706 |
FLT3 |
0.750 | -0.097 | 3 | 0.756 |
BLK |
0.749 | 0.052 | -1 | 0.780 |
KIT |
0.749 | -0.106 | 3 | 0.756 |
WEE1_TYR |
0.749 | -0.028 | -1 | 0.740 |
MERTK |
0.748 | -0.064 | 3 | 0.730 |
KDR |
0.747 | -0.114 | 3 | 0.721 |
JAK1 |
0.746 | -0.075 | 1 | 0.710 |
AXL |
0.745 | -0.121 | 3 | 0.732 |
FYN |
0.745 | 0.048 | -1 | 0.744 |
FGFR2 |
0.745 | -0.183 | 3 | 0.743 |
BTK |
0.744 | -0.113 | -1 | 0.730 |
BMX |
0.743 | -0.051 | -1 | 0.674 |
PDGFRA |
0.743 | -0.188 | 3 | 0.774 |
PTK6 |
0.743 | -0.124 | -1 | 0.705 |
MET |
0.743 | -0.105 | 3 | 0.743 |
TEK |
0.742 | -0.179 | 3 | 0.706 |
FGFR1 |
0.742 | -0.183 | 3 | 0.727 |
EPHA7 |
0.741 | -0.079 | 2 | 0.736 |
TEC |
0.741 | -0.089 | -1 | 0.696 |
LYN |
0.740 | -0.034 | 3 | 0.690 |
NEK10_TYR |
0.740 | -0.181 | 1 | 0.638 |
NTRK1 |
0.740 | -0.161 | -1 | 0.798 |
FLT1 |
0.740 | -0.112 | -1 | 0.822 |
EPHA3 |
0.740 | -0.121 | 2 | 0.714 |
LTK |
0.739 | -0.139 | 3 | 0.718 |
CK1G3 |
0.739 | -0.071 | -3 | 0.369 |
ALK |
0.739 | -0.156 | 3 | 0.692 |
ERBB2 |
0.738 | -0.155 | 1 | 0.712 |
DDR2 |
0.738 | -0.056 | 3 | 0.696 |
NTRK2 |
0.737 | -0.168 | 3 | 0.718 |
SRC |
0.737 | -0.014 | -1 | 0.745 |
FRK |
0.736 | -0.103 | -1 | 0.789 |
FLT4 |
0.736 | -0.171 | 3 | 0.723 |
INSR |
0.736 | -0.149 | 3 | 0.685 |
EPHA1 |
0.736 | -0.136 | 3 | 0.724 |
PTK2B |
0.735 | -0.067 | -1 | 0.732 |
EPHA5 |
0.735 | -0.080 | 2 | 0.724 |
NTRK3 |
0.734 | -0.122 | -1 | 0.748 |
MATK |
0.734 | -0.111 | -1 | 0.721 |
FGFR3 |
0.734 | -0.185 | 3 | 0.718 |
EPHA8 |
0.734 | -0.076 | -1 | 0.778 |
CSK |
0.733 | -0.102 | 2 | 0.742 |
PTK2 |
0.733 | 0.005 | -1 | 0.771 |
EGFR |
0.731 | -0.091 | 1 | 0.624 |
YANK2 |
0.730 | -0.116 | 2 | 0.384 |
FGFR4 |
0.728 | -0.105 | -1 | 0.746 |
SYK |
0.725 | -0.035 | -1 | 0.742 |
EPHA2 |
0.724 | -0.086 | -1 | 0.746 |
IGF1R |
0.722 | -0.142 | 3 | 0.628 |
MUSK |
0.721 | -0.161 | 1 | 0.619 |
ERBB4 |
0.718 | -0.092 | 1 | 0.631 |
CK1G2 |
0.717 | -0.085 | -3 | 0.459 |
FES |
0.712 | -0.129 | -1 | 0.658 |
ZAP70 |
0.703 | -0.075 | -1 | 0.670 |