Motif 627 (n=200)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6H8Y1 | BDP1 | S423 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A8CG34 | POM121C | S271 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| K7ELQ4 | ATF7-NPFF | S97 | ochoa | ATF7-NPFF readthrough | None |
| O00232 | PSMD12 | S332 | ochoa | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O14795 | UNC13B | S298 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O14974 | PPP1R12A | S470 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14976 | GAK | S826 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15355 | PPM1G | S242 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15550 | KDM6A | S818 | ochoa | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}. |
| O43164 | PJA2 | S454 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43295 | SRGAP3 | S1069 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43670 | ZNF207 | S358 | ochoa | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}. |
| O43822 | CFAP410 | S162 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
| O43822 | CFAP410 | S163 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
| O60268 | KIAA0513 | S74 | ochoa | Uncharacterized protein KIAA0513 | None |
| O60293 | ZFC3H1 | S949 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60716 | CTNND1 | S122 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60934 | NBN | S612 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75113 | N4BP1 | S328 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75116 | ROCK2 | S1134 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75410 | TACC1 | S91 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75410 | TACC1 | S491 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75427 | LRCH4 | S304 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O95251 | KAT7 | S53 | ochoa|psp | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95251 | KAT7 | S135 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| P04406 | GAPDH | S122 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05198 | EIF2S1 | S158 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P05814 | CSN2 | S21 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P07814 | EPRS1 | S813 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08651 | NFIC | S273 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08670 | VIM | S409 | psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P18583 | SON | S2178 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19338 | NCL | S491 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P21860 | ERBB3 | S1094 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P29374 | ARID4A | S274 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P29401 | TKT | S345 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30414 | NKTR | S808 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P39880 | CUX1 | S1215 | ochoa|psp | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41214 | EIF2D | S184 | ochoa | Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) | Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}. |
| P43121 | MCAM | S603 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P45974 | USP5 | S156 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46100 | ATRX | Y89 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46934 | NEDD4 | S739 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P47712 | PLA2G4A | S434 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P47736 | RAP1GAP | S495 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49792 | RANBP2 | S1765 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50851 | LRBA | S1061 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51805 | PLXNA3 | S1607 | ochoa | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) | Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| P51957 | NEK4 | S662 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P55082 | MFAP3 | S331 | ochoa | Microfibril-associated glycoprotein 3 | Component of the elastin-associated microfibrils. |
| P55265 | ADAR | S605 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P55957 | BID | S64 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P61981 | YWHAG | S71 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P98082 | DAB2 | S369 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01082 | SPTBN1 | S2338 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01814 | ATP2B2 | S1160 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q01831 | XPC | S502 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q05209 | PTPN12 | S514 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07157 | TJP1 | S1400 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07954 | LRP1 | S4520 | ochoa|psp | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:9252371}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. |
| Q08170 | SRSF4 | S113 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08499 | PDE4D | S375 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q08AE8 | SPIRE1 | S678 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q09666 | AHNAK | S5864 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S1025 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13243 | SRSF5 | S117 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13247 | SRSF6 | S119 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13315 | ATM | S1878 | ochoa | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13464 | ROCK1 | S1102 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13492 | PICALM | S307 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13555 | CAMK2G | S419 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13555 | CAMK2G | S423 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13895 | BYSL | S167 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q14126 | DSG2 | S884 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14141 | SEPTIN6 | S408 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14160 | SCRIB | S1223 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14677 | CLINT1 | S163 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14789 | GOLGB1 | S525 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15004 | PCLAF | S28 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15021 | NCAPD2 | S1367 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15648 | MED1 | S1479 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15746 | MYLK | S1773 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q4ADV7 | RIC1 | S1128 | ochoa | Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}. |
| Q53EZ4 | CEP55 | S163 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q59EK9 | RUNDC3A | S378 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5JTV8 | TOR1AIP1 | S228 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5QJE6 | DNTTIP2 | S117 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T0W9 | FAM83B | S563 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5TH69 | ARFGEF3 | S1848 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5THJ4 | VPS13D | S2861 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1148 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZ89 | DENND4C | S1000 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63ZY3 | KANK2 | S425 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q684P5 | RAP1GAP2 | S639 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q684P5 | RAP1GAP2 | S640 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q6PJE2 | POMZP3 | S29 | ochoa | POM121 and ZP3 fusion protein (POM-ZP3) | None |
| Q6VMQ6 | ATF7IP | S474 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6WKZ4 | RAB11FIP1 | S435 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZS30 | NBEAL1 | S1336 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q6ZU35 | CRACD | S101 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZU35 | CRACD | S1136 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUJ8 | PIK3AP1 | S142 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q6ZVL6 | KIAA1549L | S1543 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7KZ85 | SUPT6H | S1045 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7L0Y3 | TRMT10C | S80 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7Z6E9 | RBBP6 | S1622 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z7G8 | VPS13B | S411 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q7Z7L1 | SLFN11 | S750 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86UE8 | TLK2 | S35 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86WP2 | GPBP1 | S380 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86YT6 | MIB1 | S408 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IVT2 | MISP | S278 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IZQ1 | WDFY3 | S3326 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N1F7 | NUP93 | S72 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N3F8 | MICALL1 | S513 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N488 | RYBP | S210 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N573 | OXR1 | S364 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N699 | MYCT1 | S135 | ochoa | Myc target protein 1 (Myc target in myeloid cells protein 1) | May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}. |
| Q8N6H7 | ARFGAP2 | S314 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NC44 | RETREG2 | T334 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NC51 | SERBP1 | Y244 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCF5 | NFATC2IP | S231 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NEV8 | EXPH5 | S907 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEY8 | PPHLN1 | S210 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8NHV4 | NEDD1 | S493 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI08 | NCOA7 | S363 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TB24 | RIN3 | S872 | ochoa | Ras and Rab interactor 3 (Ras interaction/interference protein 3) | Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}. |
| Q8WUA4 | GTF3C2 | S773 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUJ0 | STYX | S193 | ochoa | Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) | Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. |
| Q8WUM0 | NUP133 | S489 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WWM7 | ATXN2L | S272 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WYP5 | AHCTF1 | S2060 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92614 | MYO18A | Y2035 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q96AE4 | FUBP1 | S52 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96BY6 | DOCK10 | S1289 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96BY6 | DOCK10 | S1295 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96CV9 | OPTN | S171 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96HA1 | POM121 | S294 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HI0 | SENP5 | S421 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96JJ7 | TMX3 | S434 | ochoa | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) | Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (PubMed:15623505). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:31304984). {ECO:0000269|PubMed:15623505, ECO:0000269|PubMed:31304984}. |
| Q96JK2 | DCAF5 | S459 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96MU7 | YTHDC1 | S315 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96T23 | RSF1 | S224 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T23 | RSF1 | S1246 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T88 | UHRF1 | S108 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99442 | SEC62 | S353 | ochoa | Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) | Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q99590 | SCAF11 | S472 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BSQ5 | CCM2 | S248 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BSV6 | TSEN34 | S131 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BXS6 | NUSAP1 | S60 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BXY0 | MAK16 | S197 | ochoa | Protein MAK16 homolog (NNP78) (Protein RBM13) | None |
| Q9BYT3 | STK33 | S470 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9C0E2 | XPO4 | S521 | ochoa | Exportin-4 (Exp4) | Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). {ECO:0000250|UniProtKB:Q9ESJ0, ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:26787900}. |
| Q9H0E9 | BRD8 | S582 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H2H9 | SLC38A1 | S49 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2Y7 | ZNF106 | S1279 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H3R0 | KDM4C | S479 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H3R0 | KDM4C | S482 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H410 | DSN1 | S27 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9HAF1 | MEAF6 | S122 | ochoa | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}. |
| Q9HAZ2 | PRDM16 | S1051 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HB19 | PLEKHA2 | S349 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9HCH5 | SYTL2 | S278 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NP61 | ARFGAP3 | S366 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NSI6 | BRWD1 | S2048 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NYB0 | TERF2IP | S176 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NYF8 | BCLAF1 | S760 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZB2 | FAM120A | S1041 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P243 | ZFAT | S640 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P265 | DIP2B | S80 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2D0 | IBTK | S1195 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2R6 | RERE | S53 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9P2Y5 | UVRAG | S550 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UGH3 | SLC23A2 | S78 | ochoa | Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) | Sodium/ascorbate cotransporter (PubMed:10471399, PubMed:10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399). {ECO:0000269|PubMed:10471399, ECO:0000269|PubMed:10556521}. |
| Q9UHC7 | MKRN1 | S132 | ochoa | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. |
| Q9UIW2 | PLXNA1 | S1632 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UJZ1 | STOML2 | S332 | ochoa | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}. |
| Q9UKG1 | APPL1 | S690 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9ULT8 | HECTD1 | S1530 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMZ2 | SYNRG | S1010 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UN79 | SOX13 | S453 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UNY4 | TTF2 | S268 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPN9 | TRIM33 | S809 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPV0 | CEP164 | S452 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ49 | NEU3 | S310 | ochoa | Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:10405317, PubMed:10861246, PubMed:11298736, PubMed:12011038, PubMed:15847605, PubMed:20511247, PubMed:28646141). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452). {ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:12011038, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:17334392, ECO:0000269|PubMed:20511247, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}. |
| Q9UQR1 | ZNF148 | S412 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y271 | CYSLTR1 | S313 | ochoa|psp | Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
| Q9Y2W1 | THRAP3 | S184 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2W1 | THRAP3 | S187 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3R5 | DOP1B | S586 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y3R5 | DOP1B | S717 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y485 | DMXL1 | S422 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4W2 | LAS1L | S235 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y6Q9 | NCOA3 | S772 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P18615 | NELFE | S135 | Sugiyama | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q15648 | MED1 | S932 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| P17174 | GOT1 | S82 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| O14974 | PPP1R12A | S692 | Sugiyama | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| P61244 | MAX | S129 | iPTMNet | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| Q04759 | PRKCQ | S345 | Sugiyama | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000017 | 4.777 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000035 | 4.455 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000141 | 3.850 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000160 | 3.795 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000160 | 3.795 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000204 | 3.690 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000204 | 3.690 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000229 | 3.640 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000229 | 3.640 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000181 | 3.742 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000256 | 3.591 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000286 | 3.543 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000432 | 3.365 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000476 | 3.323 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000353 | 3.452 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.000408 | 3.389 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000476 | 3.323 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000476 | 3.323 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000391 | 3.408 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000432 | 3.365 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000523 | 3.282 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000813 | 3.090 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000883 | 3.054 |
| R-HSA-109581 | Apoptosis | 0.000820 | 3.086 |
| R-HSA-75153 | Apoptotic execution phase | 0.000883 | 3.054 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.000984 | 3.007 |
| R-HSA-1640170 | Cell Cycle | 0.000902 | 3.045 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000982 | 3.008 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.001512 | 2.820 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.001983 | 2.703 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.002259 | 2.646 |
| R-HSA-191859 | snRNP Assembly | 0.002259 | 2.646 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.002561 | 2.592 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.002505 | 2.601 |
| R-HSA-3371556 | Cellular response to heat stress | 0.002516 | 2.599 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.002468 | 2.608 |
| R-HSA-4839726 | Chromatin organization | 0.003746 | 2.426 |
| R-HSA-5357801 | Programmed Cell Death | 0.003665 | 2.436 |
| R-HSA-70171 | Glycolysis | 0.004136 | 2.383 |
| R-HSA-72306 | tRNA processing | 0.004334 | 2.363 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.004504 | 2.346 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.004771 | 2.321 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005340 | 2.272 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.006264 | 2.203 |
| R-HSA-391906 | Leukotriene receptors | 0.006700 | 2.174 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.007201 | 2.143 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.008446 | 2.073 |
| R-HSA-68877 | Mitotic Prometaphase | 0.008394 | 2.076 |
| R-HSA-68886 | M Phase | 0.008811 | 2.055 |
| R-HSA-3214842 | HDMs demethylate histones | 0.008715 | 2.060 |
| R-HSA-70326 | Glucose metabolism | 0.008989 | 2.046 |
| R-HSA-199991 | Membrane Trafficking | 0.009294 | 2.032 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.009630 | 2.016 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.009493 | 2.023 |
| R-HSA-162587 | HIV Life Cycle | 0.009938 | 2.003 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.009835 | 2.007 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.010310 | 1.987 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.011386 | 1.944 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.011602 | 1.935 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.013002 | 1.886 |
| R-HSA-9664535 | LTC4-CYSLTR mediated IL4 production | 0.013498 | 1.870 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.013521 | 1.869 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.013527 | 1.869 |
| R-HSA-373755 | Semaphorin interactions | 0.015955 | 1.797 |
| R-HSA-9930044 | Nuclear RNA decay | 0.016057 | 1.794 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.017660 | 1.753 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.017660 | 1.753 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.017660 | 1.753 |
| R-HSA-162906 | HIV Infection | 0.019297 | 1.715 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.019711 | 1.705 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.020707 | 1.684 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.020707 | 1.684 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.020707 | 1.684 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.026472 | 1.577 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.026472 | 1.577 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.026472 | 1.577 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.026472 | 1.577 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.026472 | 1.577 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.024774 | 1.606 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 0.026472 | 1.577 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 0.026472 | 1.577 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.026472 | 1.577 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.023463 | 1.630 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.025378 | 1.596 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.023463 | 1.630 |
| R-HSA-8953854 | Metabolism of RNA | 0.022482 | 1.648 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.026794 | 1.572 |
| R-HSA-74160 | Gene expression (Transcription) | 0.025030 | 1.602 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.025378 | 1.596 |
| R-HSA-211000 | Gene Silencing by RNA | 0.022987 | 1.639 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.027365 | 1.563 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.027365 | 1.563 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.028174 | 1.550 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.029483 | 1.530 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.030060 | 1.522 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.031291 | 1.505 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.031674 | 1.499 |
| R-HSA-68875 | Mitotic Prophase | 0.035559 | 1.449 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.041814 | 1.379 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.038810 | 1.411 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.038810 | 1.411 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.038735 | 1.412 |
| R-HSA-392517 | Rap1 signalling | 0.041814 | 1.379 |
| R-HSA-68882 | Mitotic Anaphase | 0.041331 | 1.384 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.042112 | 1.376 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.052247 | 1.282 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.044981 | 1.347 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.044981 | 1.347 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.044981 | 1.347 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.044981 | 1.347 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.051571 | 1.288 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.051571 | 1.288 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.051571 | 1.288 |
| R-HSA-72187 | mRNA 3'-end processing | 0.047795 | 1.321 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.050096 | 1.300 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.044981 | 1.347 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.052247 | 1.282 |
| R-HSA-75102 | C6 deamination of adenosine | 0.052247 | 1.282 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.051571 | 1.288 |
| R-HSA-9843745 | Adipogenesis | 0.049330 | 1.307 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.049748 | 1.303 |
| R-HSA-69481 | G2/M Checkpoints | 0.043710 | 1.359 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.044981 | 1.347 |
| R-HSA-913531 | Interferon Signaling | 0.047463 | 1.324 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.054987 | 1.260 |
| R-HSA-5578775 | Ion homeostasis | 0.055839 | 1.253 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.057169 | 1.243 |
| R-HSA-69275 | G2/M Transition | 0.059611 | 1.225 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.061859 | 1.209 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.062267 | 1.206 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.077342 | 1.112 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.065690 | 1.183 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.071346 | 1.147 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.071346 | 1.147 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.078523 | 1.105 |
| R-HSA-191650 | Regulation of gap junction activity | 0.077342 | 1.112 |
| R-HSA-9620244 | Long-term potentiation | 0.065690 | 1.183 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.063609 | 1.196 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.069023 | 1.161 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.064484 | 1.191 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.077342 | 1.112 |
| R-HSA-73894 | DNA Repair | 0.072230 | 1.141 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.065690 | 1.183 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.073177 | 1.136 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.066736 | 1.176 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.065690 | 1.183 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.073704 | 1.133 |
| R-HSA-162582 | Signal Transduction | 0.070190 | 1.154 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.065847 | 1.181 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.079423 | 1.100 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.080924 | 1.092 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.080924 | 1.092 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.080924 | 1.092 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.080983 | 1.092 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.081291 | 1.090 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.101776 | 0.992 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.101301 | 0.994 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.105533 | 0.977 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.105533 | 0.977 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.096421 | 1.016 |
| R-HSA-380287 | Centrosome maturation | 0.101816 | 0.992 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.084888 | 1.071 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.084888 | 1.071 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.097119 | 1.013 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.101301 | 0.994 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.097119 | 1.013 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.105533 | 0.977 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.105533 | 0.977 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.105533 | 0.977 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.099973 | 1.000 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.109644 | 0.960 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.097119 | 1.013 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.097119 | 1.013 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.084888 | 1.071 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.101776 | 0.992 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.084888 | 1.071 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.092988 | 1.032 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.105533 | 0.977 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.101135 | 0.995 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.085094 | 1.070 |
| R-HSA-9610379 | HCMV Late Events | 0.088293 | 1.054 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.108873 | 0.963 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.101816 | 0.992 |
| R-HSA-9679506 | SARS-CoV Infections | 0.089324 | 1.049 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.100357 | 0.998 |
| R-HSA-5619102 | SLC transporter disorders | 0.105205 | 0.978 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.109811 | 0.959 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.114069 | 0.943 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.115515 | 0.937 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.118691 | 0.926 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.125566 | 0.901 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.137224 | 0.863 |
| R-HSA-196025 | Formation of annular gap junctions | 0.137224 | 0.863 |
| R-HSA-190873 | Gap junction degradation | 0.148728 | 0.828 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.131842 | 0.880 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.142658 | 0.846 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.148886 | 0.827 |
| R-HSA-9664873 | Pexophagy | 0.160079 | 0.796 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.160079 | 0.796 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.171280 | 0.766 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.125566 | 0.901 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.171941 | 0.765 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.174623 | 0.758 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.148728 | 0.828 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.136363 | 0.865 |
| R-HSA-1500620 | Meiosis | 0.130478 | 0.884 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.159444 | 0.797 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.137224 | 0.863 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.137224 | 0.863 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.122909 | 0.910 |
| R-HSA-69541 | Stabilization of p53 | 0.127357 | 0.895 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.148728 | 0.828 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.137224 | 0.863 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.137224 | 0.863 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.137224 | 0.863 |
| R-HSA-75072 | mRNA Editing | 0.148728 | 0.828 |
| R-HSA-9663891 | Selective autophagy | 0.142658 | 0.846 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.160079 | 0.796 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.148728 | 0.828 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.140917 | 0.851 |
| R-HSA-9766229 | Degradation of CDH1 | 0.178386 | 0.749 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.178386 | 0.749 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.131842 | 0.880 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.131842 | 0.880 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.140917 | 0.851 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.178386 | 0.749 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.178386 | 0.749 |
| R-HSA-111996 | Ca-dependent events | 0.145505 | 0.837 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.125566 | 0.901 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.136363 | 0.865 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.173159 | 0.762 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.137224 | 0.863 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.171280 | 0.766 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.171280 | 0.766 |
| R-HSA-1632852 | Macroautophagy | 0.164200 | 0.785 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.133487 | 0.875 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.127357 | 0.895 |
| R-HSA-9609690 | HCMV Early Events | 0.164411 | 0.784 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.145505 | 0.837 |
| R-HSA-9675135 | Diseases of DNA repair | 0.164144 | 0.785 |
| R-HSA-73928 | Depyrimidination | 0.145505 | 0.837 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.136363 | 0.865 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.125566 | 0.901 |
| R-HSA-168255 | Influenza Infection | 0.129385 | 0.888 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.154769 | 0.810 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.131842 | 0.880 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.140917 | 0.851 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.125722 | 0.901 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.151707 | 0.819 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.182332 | 0.739 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.203997 | 0.690 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.214615 | 0.668 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.225091 | 0.648 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.255693 | 0.592 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.275423 | 0.560 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.192809 | 0.715 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.357960 | 0.446 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.357960 | 0.446 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.357960 | 0.446 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.357960 | 0.446 |
| R-HSA-73886 | Chromosome Maintenance | 0.272068 | 0.565 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.290174 | 0.537 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.290174 | 0.537 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.290174 | 0.537 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.225091 | 0.648 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.313335 | 0.504 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.197651 | 0.704 |
| R-HSA-5693538 | Homology Directed Repair | 0.261266 | 0.583 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.249375 | 0.603 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.198611 | 0.702 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.239848 | 0.620 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.340467 | 0.468 |
| R-HSA-912446 | Meiotic recombination | 0.187984 | 0.726 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.349886 | 0.456 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.266462 | 0.574 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.193237 | 0.714 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.265624 | 0.576 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.265624 | 0.576 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.217153 | 0.663 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.357960 | 0.446 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.265624 | 0.576 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.301034 | 0.521 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.331544 | 0.479 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.313335 | 0.504 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.313640 | 0.504 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.275423 | 0.560 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.182332 | 0.739 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.214615 | 0.668 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.294633 | 0.531 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.294633 | 0.531 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.331544 | 0.479 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.201493 | 0.696 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.302541 | 0.519 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.304047 | 0.517 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.255693 | 0.592 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.271408 | 0.566 |
| R-HSA-72312 | rRNA processing | 0.251240 | 0.600 |
| R-HSA-9612973 | Autophagy | 0.206848 | 0.684 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.322501 | 0.491 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.340467 | 0.468 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.212260 | 0.673 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.349272 | 0.457 |
| R-HSA-9659379 | Sensory processing of sound | 0.325573 | 0.487 |
| R-HSA-397014 | Muscle contraction | 0.202760 | 0.693 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.245629 | 0.610 |
| R-HSA-112043 | PLC beta mediated events | 0.236816 | 0.626 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.246686 | 0.608 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.212260 | 0.673 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.203997 | 0.690 |
| R-HSA-8949664 | Processing of SMDT1 | 0.203997 | 0.690 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.225091 | 0.648 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.357960 | 0.446 |
| R-HSA-3214847 | HATs acetylate histones | 0.184580 | 0.734 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.235428 | 0.628 |
| R-HSA-5576891 | Cardiac conduction | 0.315656 | 0.501 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.349272 | 0.457 |
| R-HSA-112040 | G-protein mediated events | 0.266462 | 0.574 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.193237 | 0.714 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.193237 | 0.714 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.285092 | 0.545 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.319303 | 0.496 |
| R-HSA-1474165 | Reproduction | 0.312010 | 0.506 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.202508 | 0.694 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.182455 | 0.739 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.281296 | 0.551 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.214615 | 0.668 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.225091 | 0.648 |
| R-HSA-1237112 | Methionine salvage pathway | 0.275423 | 0.560 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.313335 | 0.504 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.331544 | 0.479 |
| R-HSA-111885 | Opioid Signalling | 0.201493 | 0.696 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.300138 | 0.523 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.182332 | 0.739 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.245629 | 0.610 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.320681 | 0.494 |
| R-HSA-9609646 | HCMV Infection | 0.297092 | 0.527 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.193237 | 0.714 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.357960 | 0.446 |
| R-HSA-4086400 | PCP/CE pathway | 0.320681 | 0.494 |
| R-HSA-422475 | Axon guidance | 0.349689 | 0.456 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.193237 | 0.714 |
| R-HSA-416700 | Other semaphorin interactions | 0.225091 | 0.648 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.265624 | 0.576 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.294633 | 0.531 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.279297 | 0.554 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.291173 | 0.536 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.301034 | 0.521 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.294633 | 0.531 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.304047 | 0.517 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.354714 | 0.450 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.344738 | 0.463 |
| R-HSA-6807070 | PTEN Regulation | 0.348471 | 0.458 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.214615 | 0.668 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.265624 | 0.576 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.285092 | 0.545 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.190478 | 0.720 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.212260 | 0.673 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.207959 | 0.682 |
| R-HSA-373753 | Nephrin family interactions | 0.285092 | 0.545 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.294633 | 0.531 |
| R-HSA-9833482 | PKR-mediated signaling | 0.330456 | 0.481 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.313335 | 0.504 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.224816 | 0.648 |
| R-HSA-418346 | Platelet homeostasis | 0.211812 | 0.674 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.271408 | 0.566 |
| R-HSA-177929 | Signaling by EGFR | 0.212260 | 0.673 |
| R-HSA-983712 | Ion channel transport | 0.305539 | 0.515 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.235428 | 0.628 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.286236 | 0.543 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.236543 | 0.626 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.250522 | 0.601 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.346254 | 0.461 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.251950 | 0.599 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.349272 | 0.457 |
| R-HSA-194138 | Signaling by VEGF | 0.290174 | 0.537 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.272068 | 0.565 |
| R-HSA-2028269 | Signaling by Hippo | 0.255693 | 0.592 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.265624 | 0.576 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.313335 | 0.504 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.358448 | 0.446 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.359530 | 0.444 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.364333 | 0.439 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.366532 | 0.436 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.366532 | 0.436 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.366532 | 0.436 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.366532 | 0.436 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.366532 | 0.436 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.366532 | 0.436 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.366532 | 0.436 |
| R-HSA-449147 | Signaling by Interleukins | 0.367650 | 0.435 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.369122 | 0.433 |
| R-HSA-9824446 | Viral Infection Pathways | 0.372356 | 0.429 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.374991 | 0.426 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.374991 | 0.426 |
| R-HSA-5334118 | DNA methylation | 0.374991 | 0.426 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.374991 | 0.426 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.374991 | 0.426 |
| R-HSA-180024 | DARPP-32 events | 0.374991 | 0.426 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.383337 | 0.416 |
| R-HSA-202424 | Downstream TCR signaling | 0.383403 | 0.416 |
| R-HSA-73884 | Base Excision Repair | 0.383403 | 0.416 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.391572 | 0.407 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.391572 | 0.407 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.391572 | 0.407 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.391572 | 0.407 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.391572 | 0.407 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.391572 | 0.407 |
| R-HSA-182971 | EGFR downregulation | 0.391572 | 0.407 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.395541 | 0.403 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.397544 | 0.401 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.399697 | 0.398 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.399697 | 0.398 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.399697 | 0.398 |
| R-HSA-1538133 | G0 and Early G1 | 0.399697 | 0.398 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.406292 | 0.391 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.406889 | 0.391 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.407715 | 0.390 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.407715 | 0.390 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.407715 | 0.390 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.407715 | 0.390 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.407715 | 0.390 |
| R-HSA-1989781 | PPARA activates gene expression | 0.409863 | 0.387 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.415517 | 0.381 |
| R-HSA-390522 | Striated Muscle Contraction | 0.415626 | 0.381 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.415626 | 0.381 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.415626 | 0.381 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.415626 | 0.381 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.416986 | 0.380 |
| R-HSA-9675108 | Nervous system development | 0.420015 | 0.377 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.420774 | 0.376 |
| R-HSA-2262752 | Cellular responses to stress | 0.422597 | 0.374 |
| R-HSA-5205647 | Mitophagy | 0.423431 | 0.373 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.423431 | 0.373 |
| R-HSA-5673000 | RAF activation | 0.423431 | 0.373 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.423431 | 0.373 |
| R-HSA-392518 | Signal amplification | 0.423431 | 0.373 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.423431 | 0.373 |
| R-HSA-157579 | Telomere Maintenance | 0.425365 | 0.371 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.425365 | 0.371 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.427619 | 0.369 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.431133 | 0.365 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.431133 | 0.365 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.431133 | 0.365 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.431133 | 0.365 |
| R-HSA-169911 | Regulation of Apoptosis | 0.431133 | 0.365 |
| R-HSA-381042 | PERK regulates gene expression | 0.431133 | 0.365 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.431133 | 0.365 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.438733 | 0.358 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.438733 | 0.358 |
| R-HSA-111933 | Calmodulin induced events | 0.438733 | 0.358 |
| R-HSA-111997 | CaM pathway | 0.438733 | 0.358 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.438733 | 0.358 |
| R-HSA-8853659 | RET signaling | 0.438733 | 0.358 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.439026 | 0.358 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.443540 | 0.353 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.445149 | 0.351 |
| R-HSA-4641258 | Degradation of DVL | 0.446231 | 0.350 |
| R-HSA-4641257 | Degradation of AXIN | 0.446231 | 0.350 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.446231 | 0.350 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.446231 | 0.350 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.446231 | 0.350 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.448034 | 0.349 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.448034 | 0.349 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.453630 | 0.343 |
| R-HSA-73927 | Depurination | 0.453630 | 0.343 |
| R-HSA-1566948 | Elastic fibre formation | 0.453630 | 0.343 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.456187 | 0.341 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.460931 | 0.336 |
| R-HSA-71336 | Pentose phosphate pathway | 0.460931 | 0.336 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.460931 | 0.336 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.460931 | 0.336 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.460931 | 0.336 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.460931 | 0.336 |
| R-HSA-9648002 | RAS processing | 0.460931 | 0.336 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.461394 | 0.336 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.461394 | 0.336 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.465805 | 0.332 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.465805 | 0.332 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.468134 | 0.330 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.468134 | 0.330 |
| R-HSA-167169 | HIV Transcription Elongation | 0.468134 | 0.330 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.468134 | 0.330 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.468134 | 0.330 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.468134 | 0.330 |
| R-HSA-9646399 | Aggrephagy | 0.468134 | 0.330 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.468134 | 0.330 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.475241 | 0.323 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.475241 | 0.323 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.475241 | 0.323 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.475241 | 0.323 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.475241 | 0.323 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.475241 | 0.323 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.475241 | 0.323 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.482254 | 0.317 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.482254 | 0.317 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.482254 | 0.317 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.482254 | 0.317 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.482254 | 0.317 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.482254 | 0.317 |
| R-HSA-202403 | TCR signaling | 0.487538 | 0.312 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.487538 | 0.312 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.487538 | 0.312 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.489174 | 0.311 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.496001 | 0.305 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.496001 | 0.305 |
| R-HSA-8854214 | TBC/RABGAPs | 0.496001 | 0.305 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.499642 | 0.301 |
| R-HSA-2559583 | Cellular Senescence | 0.499857 | 0.301 |
| R-HSA-190828 | Gap junction trafficking | 0.502738 | 0.299 |
| R-HSA-9907900 | Proteasome assembly | 0.502738 | 0.299 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.502738 | 0.299 |
| R-HSA-373752 | Netrin-1 signaling | 0.502738 | 0.299 |
| R-HSA-774815 | Nucleosome assembly | 0.509385 | 0.293 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.509385 | 0.293 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.509385 | 0.293 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.509385 | 0.293 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.509385 | 0.293 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.509385 | 0.293 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.509385 | 0.293 |
| R-HSA-9824272 | Somitogenesis | 0.509385 | 0.293 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.509385 | 0.293 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.515944 | 0.287 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.515944 | 0.287 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.515944 | 0.287 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.515944 | 0.287 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.515944 | 0.287 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.515944 | 0.287 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.515944 | 0.287 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.515944 | 0.287 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.515944 | 0.287 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.515944 | 0.287 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.517025 | 0.286 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.522415 | 0.282 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.522415 | 0.282 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.522415 | 0.282 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.527155 | 0.278 |
| R-HSA-70263 | Gluconeogenesis | 0.528800 | 0.277 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.529315 | 0.276 |
| R-HSA-5617833 | Cilium Assembly | 0.532619 | 0.274 |
| R-HSA-73893 | DNA Damage Bypass | 0.535101 | 0.272 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.540917 | 0.267 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.541317 | 0.267 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.545385 | 0.263 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.547451 | 0.262 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.547451 | 0.262 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.547451 | 0.262 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.547451 | 0.262 |
| R-HSA-2514856 | The phototransduction cascade | 0.547451 | 0.262 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.549324 | 0.260 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.553503 | 0.257 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.553503 | 0.257 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.553503 | 0.257 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.559474 | 0.252 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.559474 | 0.252 |
| R-HSA-1221632 | Meiotic synapsis | 0.559474 | 0.252 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.559474 | 0.252 |
| R-HSA-69206 | G1/S Transition | 0.561042 | 0.251 |
| R-HSA-1266738 | Developmental Biology | 0.563949 | 0.249 |
| R-HSA-72649 | Translation initiation complex formation | 0.565366 | 0.248 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.565366 | 0.248 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.571180 | 0.243 |
| R-HSA-418597 | G alpha (z) signalling events | 0.571180 | 0.243 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.571180 | 0.243 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.571180 | 0.243 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.571180 | 0.243 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.576916 | 0.239 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.576916 | 0.239 |
| R-HSA-75893 | TNF signaling | 0.576916 | 0.239 |
| R-HSA-72172 | mRNA Splicing | 0.579427 | 0.237 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.580085 | 0.237 |
| R-HSA-1483166 | Synthesis of PA | 0.582576 | 0.235 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.588160 | 0.231 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.588160 | 0.231 |
| R-HSA-9909396 | Circadian clock | 0.591219 | 0.228 |
| R-HSA-180786 | Extension of Telomeres | 0.593670 | 0.226 |
| R-HSA-4085001 | Sialic acid metabolism | 0.593670 | 0.226 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.593670 | 0.226 |
| R-HSA-379724 | tRNA Aminoacylation | 0.599107 | 0.222 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.599107 | 0.222 |
| R-HSA-351202 | Metabolism of polyamines | 0.599107 | 0.222 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.599107 | 0.222 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.599107 | 0.222 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.599107 | 0.222 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.599107 | 0.222 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.604471 | 0.219 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.604471 | 0.219 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.606066 | 0.217 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.609286 | 0.215 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.609286 | 0.215 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.609763 | 0.215 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.609763 | 0.215 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.609763 | 0.215 |
| R-HSA-9707616 | Heme signaling | 0.609763 | 0.215 |
| R-HSA-186797 | Signaling by PDGF | 0.609763 | 0.215 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.609763 | 0.215 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.612826 | 0.213 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.614986 | 0.211 |
| R-HSA-8848021 | Signaling by PTK6 | 0.614986 | 0.211 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.614986 | 0.211 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.625222 | 0.204 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.625222 | 0.204 |
| R-HSA-8951664 | Neddylation | 0.628793 | 0.201 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.630239 | 0.200 |
| R-HSA-212436 | Generic Transcription Pathway | 0.632863 | 0.199 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.635188 | 0.197 |
| R-HSA-167172 | Transcription of the HIV genome | 0.640072 | 0.194 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.640269 | 0.194 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.646887 | 0.189 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.649644 | 0.187 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.649644 | 0.187 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.649644 | 0.187 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.649644 | 0.187 |
| R-HSA-2187338 | Visual phototransduction | 0.650160 | 0.187 |
| R-HSA-69242 | S Phase | 0.653409 | 0.185 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.653409 | 0.185 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.654335 | 0.184 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.654335 | 0.184 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.654335 | 0.184 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.654335 | 0.184 |
| R-HSA-9758941 | Gastrulation | 0.656634 | 0.183 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.658964 | 0.181 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.663530 | 0.178 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.663530 | 0.178 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.668036 | 0.175 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.670585 | 0.174 |
| R-HSA-8852135 | Protein ubiquitination | 0.672482 | 0.172 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.672482 | 0.172 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.672482 | 0.172 |
| R-HSA-5689603 | UCH proteinases | 0.676868 | 0.169 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.676868 | 0.169 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.677248 | 0.169 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.684591 | 0.165 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.685467 | 0.164 |
| R-HSA-5619084 | ABC transporter disorders | 0.685467 | 0.164 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.689680 | 0.161 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.690546 | 0.161 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.697939 | 0.156 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.697939 | 0.156 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.705979 | 0.151 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.705979 | 0.151 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.709919 | 0.149 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.710835 | 0.148 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.713806 | 0.146 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.721426 | 0.142 |
| R-HSA-418555 | G alpha (s) signalling events | 0.724360 | 0.140 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.727032 | 0.138 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.729683 | 0.137 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.729683 | 0.137 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.729683 | 0.137 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.729683 | 0.137 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.729683 | 0.137 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.732478 | 0.135 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.734919 | 0.134 |
| R-HSA-416476 | G alpha (q) signalling events | 0.735217 | 0.134 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.736064 | 0.133 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.739603 | 0.131 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.749937 | 0.125 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.749937 | 0.125 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.755012 | 0.122 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.756212 | 0.121 |
| R-HSA-168256 | Immune System | 0.758856 | 0.120 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.759863 | 0.119 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.759863 | 0.119 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.763084 | 0.117 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.766262 | 0.116 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.769397 | 0.114 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.769397 | 0.114 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.769397 | 0.114 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.772491 | 0.112 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.773783 | 0.111 |
| R-HSA-1280218 | Adaptive Immune System | 0.774358 | 0.111 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.775543 | 0.110 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.776039 | 0.110 |
| R-HSA-1483255 | PI Metabolism | 0.781525 | 0.107 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.784870 | 0.105 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.787349 | 0.104 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.787349 | 0.104 |
| R-HSA-9833110 | RSV-host interactions | 0.790203 | 0.102 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.793395 | 0.101 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.795797 | 0.099 |
| R-HSA-69239 | Synthesis of DNA | 0.798537 | 0.098 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.798537 | 0.098 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.798537 | 0.098 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.799592 | 0.097 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.799592 | 0.097 |
| R-HSA-195721 | Signaling by WNT | 0.801162 | 0.096 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.801242 | 0.096 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.801242 | 0.096 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.801242 | 0.096 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.801242 | 0.096 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.801242 | 0.096 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.803910 | 0.095 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.803910 | 0.095 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.814230 | 0.089 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.816725 | 0.088 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.819080 | 0.087 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.821614 | 0.085 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.821614 | 0.085 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.826374 | 0.083 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.826374 | 0.083 |
| R-HSA-373760 | L1CAM interactions | 0.826374 | 0.083 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.828706 | 0.082 |
| R-HSA-418990 | Adherens junctions interactions | 0.829945 | 0.081 |
| R-HSA-1500931 | Cell-Cell communication | 0.830157 | 0.081 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.833277 | 0.079 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.833277 | 0.079 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.833277 | 0.079 |
| R-HSA-5663205 | Infectious disease | 0.837865 | 0.077 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.839907 | 0.076 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.839907 | 0.076 |
| R-HSA-388396 | GPCR downstream signalling | 0.840447 | 0.075 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.842059 | 0.075 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.844181 | 0.074 |
| R-HSA-114608 | Platelet degranulation | 0.852391 | 0.069 |
| R-HSA-8939211 | ESR-mediated signaling | 0.860588 | 0.065 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.862050 | 0.064 |
| R-HSA-157118 | Signaling by NOTCH | 0.864939 | 0.063 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.865735 | 0.063 |
| R-HSA-163685 | Integration of energy metabolism | 0.872813 | 0.059 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.876212 | 0.057 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.876212 | 0.057 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.877878 | 0.057 |
| R-HSA-421270 | Cell-cell junction organization | 0.879853 | 0.056 |
| R-HSA-5688426 | Deubiquitination | 0.884890 | 0.053 |
| R-HSA-6798695 | Neutrophil degranulation | 0.885608 | 0.053 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.886119 | 0.053 |
| R-HSA-112316 | Neuronal System | 0.895788 | 0.048 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.896204 | 0.048 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.896204 | 0.048 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.898981 | 0.046 |
| R-HSA-2142753 | Arachidonate metabolism | 0.898981 | 0.046 |
| R-HSA-69306 | DNA Replication | 0.900341 | 0.046 |
| R-HSA-73887 | Death Receptor Signaling | 0.901683 | 0.045 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.905602 | 0.043 |
| R-HSA-372790 | Signaling by GPCR | 0.906607 | 0.043 |
| R-HSA-9711097 | Cellular response to starvation | 0.906874 | 0.042 |
| R-HSA-877300 | Interferon gamma signaling | 0.908128 | 0.042 |
| R-HSA-446728 | Cell junction organization | 0.910262 | 0.041 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.913157 | 0.039 |
| R-HSA-9658195 | Leishmania infection | 0.913157 | 0.039 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.914153 | 0.039 |
| R-HSA-597592 | Post-translational protein modification | 0.914971 | 0.039 |
| R-HSA-1643685 | Disease | 0.920299 | 0.036 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.922984 | 0.035 |
| R-HSA-1483257 | Phospholipid metabolism | 0.925552 | 0.034 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.927055 | 0.033 |
| R-HSA-418594 | G alpha (i) signalling events | 0.928064 | 0.032 |
| R-HSA-611105 | Respiratory electron transport | 0.929967 | 0.032 |
| R-HSA-72766 | Translation | 0.942081 | 0.026 |
| R-HSA-428157 | Sphingolipid metabolism | 0.948766 | 0.023 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.950141 | 0.022 |
| R-HSA-1474244 | Extracellular matrix organization | 0.950220 | 0.022 |
| R-HSA-6805567 | Keratinization | 0.952781 | 0.021 |
| R-HSA-109582 | Hemostasis | 0.961301 | 0.017 |
| R-HSA-382551 | Transport of small molecules | 0.961733 | 0.017 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.965435 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.965830 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.965943 | 0.015 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.976138 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 0.990574 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.992113 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992534 | 0.003 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.996245 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.996590 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997029 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.997734 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.997842 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.999334 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999967 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999972 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.815 | 0.104 | 2 | 0.836 |
CDC7 |
0.811 | 0.113 | 1 | 0.858 |
CLK3 |
0.811 | 0.110 | 1 | 0.814 |
GRK1 |
0.807 | 0.170 | -2 | 0.793 |
MOS |
0.807 | 0.155 | 1 | 0.862 |
GRK6 |
0.804 | 0.179 | 1 | 0.840 |
CAMK2G |
0.801 | 0.132 | 2 | 0.806 |
RSK2 |
0.799 | 0.114 | -3 | 0.829 |
PIM3 |
0.798 | 0.056 | -3 | 0.881 |
CAMK1B |
0.798 | 0.067 | -3 | 0.905 |
IKKB |
0.798 | -0.003 | -2 | 0.773 |
NDR2 |
0.795 | 0.024 | -3 | 0.876 |
BMPR1B |
0.795 | 0.146 | 1 | 0.857 |
CAMK2B |
0.795 | 0.147 | 2 | 0.796 |
RAF1 |
0.795 | -0.040 | 1 | 0.822 |
CAMK2A |
0.794 | 0.170 | 2 | 0.807 |
PRPK |
0.794 | -0.083 | -1 | 0.762 |
MTOR |
0.793 | 0.041 | 1 | 0.758 |
SRPK1 |
0.793 | 0.041 | -3 | 0.818 |
SKMLCK |
0.793 | 0.046 | -2 | 0.863 |
GRK5 |
0.792 | 0.054 | -3 | 0.896 |
CK2A2 |
0.792 | 0.142 | 1 | 0.767 |
DSTYK |
0.790 | -0.022 | 2 | 0.831 |
ATR |
0.789 | 0.030 | 1 | 0.807 |
CLK2 |
0.789 | 0.118 | -3 | 0.805 |
KIS |
0.789 | 0.019 | 1 | 0.683 |
GRK7 |
0.789 | 0.125 | 1 | 0.763 |
CDKL1 |
0.789 | 0.031 | -3 | 0.863 |
RIPK3 |
0.789 | -0.058 | 3 | 0.217 |
P90RSK |
0.789 | 0.062 | -3 | 0.829 |
HIPK4 |
0.789 | 0.021 | 1 | 0.805 |
IKKA |
0.788 | 0.025 | -2 | 0.765 |
NLK |
0.788 | -0.026 | 1 | 0.815 |
FAM20C |
0.788 | 0.051 | 2 | 0.598 |
PDHK4 |
0.787 | -0.081 | 1 | 0.824 |
GRK4 |
0.787 | 0.028 | -2 | 0.831 |
ERK5 |
0.787 | -0.011 | 1 | 0.798 |
CK2A1 |
0.787 | 0.152 | 1 | 0.754 |
BMPR2 |
0.786 | -0.117 | -2 | 0.887 |
MAPKAPK2 |
0.786 | 0.059 | -3 | 0.782 |
HUNK |
0.786 | -0.078 | 2 | 0.814 |
IKKE |
0.786 | -0.072 | 1 | 0.698 |
CAMLCK |
0.786 | 0.006 | -2 | 0.858 |
GCN2 |
0.786 | -0.140 | 2 | 0.773 |
PIM1 |
0.785 | 0.051 | -3 | 0.839 |
RSK4 |
0.785 | 0.104 | -3 | 0.801 |
PRKD1 |
0.785 | 0.012 | -3 | 0.856 |
TGFBR1 |
0.785 | 0.082 | -2 | 0.812 |
TBK1 |
0.785 | -0.109 | 1 | 0.698 |
PASK |
0.785 | 0.254 | -3 | 0.897 |
DAPK2 |
0.784 | 0.022 | -3 | 0.904 |
NDR1 |
0.783 | -0.018 | -3 | 0.873 |
MSK1 |
0.783 | 0.099 | -3 | 0.803 |
CAMK2D |
0.783 | 0.048 | -3 | 0.871 |
DLK |
0.783 | 0.085 | 1 | 0.816 |
GSK3B |
0.782 | 0.207 | 4 | 0.584 |
NUAK2 |
0.782 | -0.033 | -3 | 0.879 |
WNK1 |
0.782 | -0.048 | -2 | 0.872 |
ACVR2B |
0.782 | 0.114 | -2 | 0.814 |
GSK3A |
0.782 | 0.213 | 4 | 0.592 |
PRKD2 |
0.782 | 0.028 | -3 | 0.808 |
SRPK3 |
0.781 | 0.019 | -3 | 0.797 |
PKN3 |
0.781 | -0.026 | -3 | 0.864 |
TSSK2 |
0.780 | -0.025 | -5 | 0.869 |
ATM |
0.780 | 0.002 | 1 | 0.749 |
RSK3 |
0.780 | 0.038 | -3 | 0.815 |
SRPK2 |
0.780 | 0.029 | -3 | 0.748 |
CDK1 |
0.780 | 0.061 | 1 | 0.652 |
PLK1 |
0.780 | 0.042 | -2 | 0.814 |
DYRK2 |
0.780 | 0.038 | 1 | 0.721 |
NIK |
0.780 | -0.067 | -3 | 0.908 |
BMPR1A |
0.780 | 0.111 | 1 | 0.828 |
CDKL5 |
0.779 | 0.007 | -3 | 0.854 |
P70S6KB |
0.779 | 0.024 | -3 | 0.845 |
ALK4 |
0.779 | 0.039 | -2 | 0.838 |
LATS1 |
0.779 | 0.079 | -3 | 0.888 |
GRK2 |
0.778 | 0.079 | -2 | 0.737 |
PKN2 |
0.778 | -0.018 | -3 | 0.874 |
ACVR2A |
0.778 | 0.071 | -2 | 0.800 |
PKACG |
0.778 | 0.016 | -2 | 0.757 |
LATS2 |
0.778 | -0.009 | -5 | 0.743 |
ICK |
0.778 | 0.010 | -3 | 0.890 |
ALK2 |
0.778 | 0.075 | -2 | 0.819 |
CHAK2 |
0.778 | -0.079 | -1 | 0.749 |
RIPK1 |
0.777 | -0.081 | 1 | 0.786 |
MLK1 |
0.777 | -0.098 | 2 | 0.741 |
MARK4 |
0.777 | -0.090 | 4 | 0.805 |
MSK2 |
0.777 | 0.038 | -3 | 0.806 |
CLK4 |
0.777 | 0.050 | -3 | 0.826 |
AMPKA1 |
0.777 | -0.066 | -3 | 0.880 |
TGFBR2 |
0.777 | -0.085 | -2 | 0.802 |
PRKX |
0.776 | 0.093 | -3 | 0.732 |
NEK7 |
0.776 | -0.139 | -3 | 0.862 |
PDHK1 |
0.776 | -0.180 | 1 | 0.802 |
NEK6 |
0.776 | -0.119 | -2 | 0.863 |
ULK2 |
0.775 | -0.190 | 2 | 0.734 |
MST4 |
0.775 | -0.070 | 2 | 0.774 |
JNK2 |
0.775 | 0.057 | 1 | 0.624 |
AURC |
0.775 | 0.015 | -2 | 0.672 |
MYLK4 |
0.775 | 0.028 | -2 | 0.784 |
JNK3 |
0.774 | 0.046 | 1 | 0.651 |
MAPKAPK3 |
0.774 | -0.021 | -3 | 0.814 |
TSSK1 |
0.774 | -0.048 | -3 | 0.890 |
MASTL |
0.774 | -0.116 | -2 | 0.804 |
DNAPK |
0.773 | 0.068 | 1 | 0.677 |
PKACB |
0.773 | 0.053 | -2 | 0.691 |
DYRK4 |
0.772 | 0.065 | 1 | 0.642 |
CLK1 |
0.772 | 0.040 | -3 | 0.801 |
PLK3 |
0.772 | 0.021 | 2 | 0.776 |
DRAK1 |
0.771 | 0.062 | 1 | 0.804 |
ANKRD3 |
0.771 | -0.100 | 1 | 0.819 |
AMPKA2 |
0.771 | -0.061 | -3 | 0.854 |
CAMK4 |
0.770 | -0.035 | -3 | 0.857 |
MEK1 |
0.770 | -0.023 | 2 | 0.829 |
NIM1 |
0.770 | -0.103 | 3 | 0.217 |
WNK3 |
0.770 | -0.194 | 1 | 0.776 |
ULK1 |
0.770 | -0.140 | -3 | 0.828 |
PAK1 |
0.770 | -0.013 | -2 | 0.784 |
CDK2 |
0.770 | 0.009 | 1 | 0.724 |
AURA |
0.769 | 0.028 | -2 | 0.635 |
GRK3 |
0.769 | 0.069 | -2 | 0.691 |
CDK8 |
0.768 | -0.021 | 1 | 0.663 |
TLK2 |
0.768 | -0.017 | 1 | 0.788 |
BCKDK |
0.768 | -0.154 | -1 | 0.683 |
CK1E |
0.768 | 0.047 | -3 | 0.634 |
PKCD |
0.767 | -0.075 | 2 | 0.707 |
QSK |
0.766 | -0.061 | 4 | 0.773 |
BRSK1 |
0.766 | -0.045 | -3 | 0.829 |
CDK3 |
0.766 | 0.017 | 1 | 0.581 |
TTBK2 |
0.766 | -0.116 | 2 | 0.665 |
PKR |
0.765 | -0.074 | 1 | 0.818 |
SMG1 |
0.765 | 0.006 | 1 | 0.756 |
HIPK2 |
0.765 | 0.030 | 1 | 0.636 |
JNK1 |
0.765 | 0.056 | 1 | 0.613 |
PRKD3 |
0.765 | -0.008 | -3 | 0.796 |
P38B |
0.765 | 0.036 | 1 | 0.638 |
AURB |
0.764 | -0.009 | -2 | 0.666 |
MARK3 |
0.764 | -0.048 | 4 | 0.745 |
CAMK1G |
0.764 | 0.016 | -3 | 0.818 |
IRE1 |
0.763 | -0.155 | 1 | 0.774 |
CK1A2 |
0.763 | 0.067 | -3 | 0.590 |
MLK3 |
0.763 | -0.084 | 2 | 0.656 |
CDK7 |
0.763 | -0.031 | 1 | 0.675 |
P38A |
0.763 | 0.005 | 1 | 0.702 |
VRK2 |
0.762 | -0.177 | 1 | 0.837 |
MEKK3 |
0.762 | -0.028 | 1 | 0.786 |
PAK3 |
0.762 | -0.068 | -2 | 0.784 |
AKT2 |
0.762 | 0.030 | -3 | 0.753 |
NUAK1 |
0.762 | -0.066 | -3 | 0.831 |
HIPK1 |
0.762 | 0.017 | 1 | 0.728 |
NEK9 |
0.762 | -0.203 | 2 | 0.770 |
CDK19 |
0.762 | -0.024 | 1 | 0.626 |
YSK4 |
0.761 | -0.059 | 1 | 0.750 |
MLK2 |
0.761 | -0.170 | 2 | 0.751 |
MELK |
0.761 | -0.083 | -3 | 0.838 |
PLK2 |
0.761 | 0.083 | -3 | 0.778 |
MLK4 |
0.760 | -0.078 | 2 | 0.652 |
MARK2 |
0.760 | -0.069 | 4 | 0.714 |
CDK5 |
0.760 | -0.037 | 1 | 0.692 |
CK1D |
0.760 | 0.048 | -3 | 0.589 |
QIK |
0.759 | -0.123 | -3 | 0.867 |
PKG2 |
0.759 | -0.010 | -2 | 0.699 |
GAK |
0.759 | 0.102 | 1 | 0.807 |
BRAF |
0.759 | -0.053 | -4 | 0.842 |
P38G |
0.759 | 0.015 | 1 | 0.559 |
PAK2 |
0.759 | -0.065 | -2 | 0.765 |
PAK6 |
0.759 | -0.017 | -2 | 0.710 |
MNK2 |
0.758 | -0.068 | -2 | 0.795 |
MARK1 |
0.758 | -0.069 | 4 | 0.759 |
SIK |
0.758 | -0.063 | -3 | 0.809 |
DYRK1A |
0.758 | 0.008 | 1 | 0.726 |
MNK1 |
0.758 | -0.051 | -2 | 0.809 |
ERK1 |
0.758 | -0.006 | 1 | 0.625 |
PKCB |
0.758 | -0.068 | 2 | 0.649 |
CDK13 |
0.757 | -0.037 | 1 | 0.645 |
MAPKAPK5 |
0.757 | -0.037 | -3 | 0.772 |
SGK3 |
0.757 | -0.007 | -3 | 0.808 |
TLK1 |
0.757 | -0.060 | -2 | 0.843 |
DAPK1 |
0.757 | 0.072 | -3 | 0.836 |
CDK18 |
0.757 | -0.002 | 1 | 0.607 |
PKACA |
0.756 | 0.038 | -2 | 0.647 |
PIM2 |
0.756 | 0.001 | -3 | 0.804 |
PKCG |
0.756 | -0.077 | 2 | 0.651 |
CHK1 |
0.756 | -0.056 | -3 | 0.833 |
ERK2 |
0.756 | -0.022 | 1 | 0.667 |
IRE2 |
0.756 | -0.166 | 2 | 0.672 |
SMMLCK |
0.756 | 0.001 | -3 | 0.867 |
DCAMKL1 |
0.755 | -0.023 | -3 | 0.819 |
P38D |
0.755 | 0.029 | 1 | 0.562 |
SSTK |
0.755 | -0.061 | 4 | 0.764 |
BRSK2 |
0.755 | -0.104 | -3 | 0.846 |
CK1G1 |
0.755 | -0.005 | -3 | 0.636 |
SNRK |
0.755 | -0.140 | 2 | 0.646 |
DYRK1B |
0.754 | 0.009 | 1 | 0.663 |
CDK17 |
0.753 | -0.002 | 1 | 0.562 |
DYRK3 |
0.753 | 0.017 | 1 | 0.736 |
PRP4 |
0.752 | -0.032 | -3 | 0.741 |
PKCA |
0.752 | -0.082 | 2 | 0.636 |
DAPK3 |
0.752 | 0.028 | -3 | 0.847 |
PLK4 |
0.751 | -0.121 | 2 | 0.640 |
MEK5 |
0.751 | -0.168 | 2 | 0.777 |
PKCH |
0.751 | -0.089 | 2 | 0.640 |
DCAMKL2 |
0.751 | -0.018 | -3 | 0.843 |
CDK12 |
0.751 | -0.034 | 1 | 0.619 |
CDK9 |
0.750 | -0.050 | 1 | 0.649 |
P70S6K |
0.750 | -0.005 | -3 | 0.767 |
CDK14 |
0.750 | -0.004 | 1 | 0.648 |
HIPK3 |
0.750 | -0.025 | 1 | 0.711 |
CAMK1D |
0.750 | 0.007 | -3 | 0.737 |
PKCZ |
0.749 | -0.119 | 2 | 0.699 |
MST3 |
0.749 | -0.047 | 2 | 0.762 |
CHAK1 |
0.749 | -0.184 | 2 | 0.685 |
MEKK2 |
0.749 | -0.133 | 2 | 0.747 |
CDK10 |
0.748 | 0.010 | 1 | 0.636 |
WNK4 |
0.748 | -0.148 | -2 | 0.853 |
PINK1 |
0.748 | -0.140 | 1 | 0.811 |
NEK2 |
0.747 | -0.176 | 2 | 0.738 |
PHKG1 |
0.747 | -0.133 | -3 | 0.860 |
ZAK |
0.747 | -0.134 | 1 | 0.748 |
PERK |
0.746 | -0.188 | -2 | 0.840 |
TAO3 |
0.746 | -0.080 | 1 | 0.771 |
MEKK1 |
0.746 | -0.193 | 1 | 0.767 |
MPSK1 |
0.745 | -0.072 | 1 | 0.763 |
HRI |
0.745 | -0.205 | -2 | 0.855 |
AKT1 |
0.745 | -0.004 | -3 | 0.764 |
TAK1 |
0.744 | 0.046 | 1 | 0.807 |
GCK |
0.744 | 0.016 | 1 | 0.803 |
CAMKK1 |
0.743 | -0.093 | -2 | 0.779 |
CDK16 |
0.743 | -0.001 | 1 | 0.574 |
NEK5 |
0.742 | -0.183 | 1 | 0.789 |
NEK11 |
0.742 | -0.086 | 1 | 0.766 |
SGK1 |
0.741 | 0.040 | -3 | 0.680 |
YANK3 |
0.741 | 0.044 | 2 | 0.397 |
IRAK1 |
0.741 | -0.195 | -1 | 0.660 |
CAMKK2 |
0.740 | -0.072 | -2 | 0.774 |
TTBK1 |
0.740 | -0.117 | 2 | 0.584 |
PAK4 |
0.740 | -0.023 | -2 | 0.637 |
IRAK4 |
0.740 | -0.190 | 1 | 0.762 |
MAK |
0.739 | 0.039 | -2 | 0.747 |
PDHK3_TYR |
0.739 | 0.215 | 4 | 0.870 |
MRCKA |
0.738 | 0.014 | -3 | 0.805 |
PDK1 |
0.738 | -0.093 | 1 | 0.745 |
NEK8 |
0.738 | -0.161 | 2 | 0.739 |
LKB1 |
0.738 | -0.110 | -3 | 0.831 |
PAK5 |
0.737 | -0.044 | -2 | 0.629 |
HPK1 |
0.737 | -0.014 | 1 | 0.787 |
EEF2K |
0.737 | -0.100 | 3 | 0.270 |
BMPR2_TYR |
0.736 | 0.241 | -1 | 0.842 |
AKT3 |
0.736 | 0.018 | -3 | 0.695 |
CHK2 |
0.736 | 0.000 | -3 | 0.699 |
MST2 |
0.735 | -0.074 | 1 | 0.791 |
PDHK4_TYR |
0.735 | 0.198 | 2 | 0.842 |
PHKG2 |
0.734 | -0.119 | -3 | 0.834 |
STK33 |
0.734 | -0.067 | 2 | 0.589 |
MAP2K6_TYR |
0.734 | 0.173 | -1 | 0.798 |
PKCE |
0.734 | -0.057 | 2 | 0.630 |
PKCT |
0.733 | -0.121 | 2 | 0.646 |
PKCI |
0.733 | -0.104 | 2 | 0.663 |
MRCKB |
0.733 | -0.010 | -3 | 0.790 |
CK1A |
0.732 | 0.044 | -3 | 0.502 |
DMPK1 |
0.732 | 0.034 | -3 | 0.814 |
VRK1 |
0.732 | -0.134 | 2 | 0.797 |
SBK |
0.732 | 0.033 | -3 | 0.640 |
MOK |
0.732 | 0.007 | 1 | 0.754 |
TAO2 |
0.732 | -0.171 | 2 | 0.768 |
ERK7 |
0.732 | -0.046 | 2 | 0.464 |
CAMK1A |
0.732 | -0.009 | -3 | 0.717 |
PDHK1_TYR |
0.732 | 0.176 | -1 | 0.827 |
ROCK2 |
0.731 | -0.018 | -3 | 0.829 |
MINK |
0.731 | -0.111 | 1 | 0.771 |
LRRK2 |
0.731 | -0.126 | 2 | 0.782 |
BUB1 |
0.730 | -0.021 | -5 | 0.814 |
CDK6 |
0.730 | -0.049 | 1 | 0.619 |
TNIK |
0.729 | -0.130 | 3 | 0.260 |
ALPHAK3 |
0.729 | 0.041 | -1 | 0.721 |
CDK4 |
0.729 | -0.044 | 1 | 0.608 |
NEK4 |
0.728 | -0.195 | 1 | 0.759 |
MAP3K15 |
0.728 | -0.149 | 1 | 0.725 |
KHS2 |
0.727 | -0.062 | 1 | 0.785 |
MAP2K4_TYR |
0.727 | 0.059 | -1 | 0.782 |
RIPK2 |
0.727 | -0.182 | 1 | 0.701 |
HGK |
0.727 | -0.151 | 3 | 0.264 |
MEKK6 |
0.727 | -0.169 | 1 | 0.765 |
PKN1 |
0.726 | -0.064 | -3 | 0.779 |
MST1 |
0.726 | -0.097 | 1 | 0.770 |
CRIK |
0.725 | 0.027 | -3 | 0.767 |
SLK |
0.725 | -0.087 | -2 | 0.712 |
KHS1 |
0.724 | -0.094 | 1 | 0.762 |
EPHA6 |
0.724 | 0.049 | -1 | 0.832 |
NEK1 |
0.722 | -0.206 | 1 | 0.759 |
TESK1_TYR |
0.722 | -0.091 | 3 | 0.280 |
PBK |
0.721 | -0.075 | 1 | 0.716 |
LOK |
0.721 | -0.147 | -2 | 0.772 |
MEK2 |
0.720 | -0.207 | 2 | 0.787 |
TTK |
0.720 | -0.083 | -2 | 0.823 |
TXK |
0.720 | 0.054 | 1 | 0.851 |
HASPIN |
0.720 | -0.042 | -1 | 0.639 |
OSR1 |
0.718 | -0.087 | 2 | 0.754 |
MAP2K7_TYR |
0.718 | -0.131 | 2 | 0.815 |
EPHA4 |
0.718 | 0.051 | 2 | 0.776 |
PKMYT1_TYR |
0.717 | -0.138 | 3 | 0.258 |
PKG1 |
0.715 | -0.040 | -2 | 0.613 |
PINK1_TYR |
0.715 | -0.123 | 1 | 0.810 |
ROCK1 |
0.715 | -0.028 | -3 | 0.799 |
EPHB4 |
0.715 | -0.041 | -1 | 0.767 |
CK1G2 |
0.715 | 0.070 | -3 | 0.550 |
PTK2 |
0.713 | 0.146 | -1 | 0.838 |
YSK1 |
0.713 | -0.180 | 2 | 0.723 |
INSRR |
0.713 | -0.067 | 3 | 0.185 |
FYN |
0.712 | 0.069 | -1 | 0.811 |
SRMS |
0.711 | -0.021 | 1 | 0.840 |
FGR |
0.711 | -0.046 | 1 | 0.820 |
EPHB1 |
0.710 | -0.035 | 1 | 0.828 |
BIKE |
0.710 | -0.054 | 1 | 0.674 |
FER |
0.710 | -0.067 | 1 | 0.841 |
YES1 |
0.709 | -0.074 | -1 | 0.768 |
CK1G3 |
0.709 | 0.022 | -3 | 0.456 |
ITK |
0.708 | -0.042 | -1 | 0.737 |
EPHB2 |
0.708 | -0.028 | -1 | 0.754 |
YANK2 |
0.708 | 0.028 | 2 | 0.407 |
LIMK2_TYR |
0.707 | -0.165 | -3 | 0.903 |
BLK |
0.707 | -0.020 | -1 | 0.820 |
DDR1 |
0.707 | -0.109 | 4 | 0.799 |
ABL2 |
0.706 | -0.123 | -1 | 0.743 |
ASK1 |
0.706 | -0.163 | 1 | 0.710 |
BMX |
0.705 | -0.032 | -1 | 0.675 |
HCK |
0.705 | -0.082 | -1 | 0.791 |
EPHB3 |
0.705 | -0.072 | -1 | 0.756 |
LCK |
0.705 | -0.049 | -1 | 0.809 |
RET |
0.705 | -0.216 | 1 | 0.759 |
EPHA7 |
0.704 | -0.020 | 2 | 0.765 |
JAK3 |
0.704 | -0.105 | 1 | 0.740 |
SYK |
0.703 | 0.119 | -1 | 0.812 |
FGFR2 |
0.703 | -0.091 | 3 | 0.237 |
CSF1R |
0.703 | -0.187 | 3 | 0.180 |
MST1R |
0.703 | -0.232 | 3 | 0.194 |
ABL1 |
0.703 | -0.114 | -1 | 0.730 |
MYO3A |
0.703 | -0.138 | 1 | 0.766 |
TYRO3 |
0.702 | -0.243 | 3 | 0.188 |
MYO3B |
0.701 | -0.154 | 2 | 0.733 |
KIT |
0.701 | -0.125 | 3 | 0.195 |
LIMK1_TYR |
0.701 | -0.257 | 2 | 0.785 |
FLT1 |
0.701 | 0.000 | -1 | 0.811 |
EPHA3 |
0.701 | -0.036 | 2 | 0.741 |
ROS1 |
0.701 | -0.256 | 3 | 0.170 |
TNK2 |
0.700 | -0.149 | 3 | 0.180 |
EPHA5 |
0.700 | -0.013 | 2 | 0.764 |
STLK3 |
0.699 | -0.130 | 1 | 0.719 |
MET |
0.699 | -0.096 | 3 | 0.182 |
NEK3 |
0.699 | -0.266 | 1 | 0.707 |
TEC |
0.698 | -0.092 | -1 | 0.658 |
KDR |
0.698 | -0.136 | 3 | 0.179 |
EPHA8 |
0.698 | -0.009 | -1 | 0.794 |
FGFR3 |
0.698 | -0.070 | 3 | 0.221 |
MERTK |
0.698 | -0.129 | 3 | 0.180 |
JAK2 |
0.697 | -0.267 | 1 | 0.743 |
SRC |
0.697 | -0.026 | -1 | 0.779 |
TEK |
0.697 | -0.173 | 3 | 0.171 |
TYK2 |
0.696 | -0.316 | 1 | 0.750 |
DDR2 |
0.696 | -0.061 | 3 | 0.195 |
LYN |
0.696 | -0.082 | 3 | 0.165 |
PTK2B |
0.695 | -0.052 | -1 | 0.682 |
ERBB2 |
0.694 | -0.096 | 1 | 0.723 |
ERBB4 |
0.694 | 0.014 | 1 | 0.675 |
EPHA2 |
0.693 | -0.000 | -1 | 0.762 |
FRK |
0.693 | -0.092 | -1 | 0.801 |
TAO1 |
0.693 | -0.205 | 1 | 0.689 |
AXL |
0.692 | -0.189 | 3 | 0.183 |
FLT3 |
0.692 | -0.209 | 3 | 0.182 |
FGFR1 |
0.691 | -0.202 | 3 | 0.180 |
NTRK1 |
0.691 | -0.156 | -1 | 0.723 |
AAK1 |
0.691 | -0.038 | 1 | 0.572 |
LTK |
0.690 | -0.169 | 3 | 0.172 |
INSR |
0.690 | -0.151 | 3 | 0.167 |
PDGFRB |
0.690 | -0.244 | 3 | 0.192 |
BTK |
0.690 | -0.180 | -1 | 0.680 |
FLT4 |
0.690 | -0.133 | 3 | 0.202 |
ALK |
0.689 | -0.199 | 3 | 0.153 |
WEE1_TYR |
0.688 | -0.117 | -1 | 0.649 |
EGFR |
0.688 | -0.037 | 1 | 0.631 |
TNK1 |
0.687 | -0.218 | 3 | 0.182 |
FGFR4 |
0.687 | -0.059 | -1 | 0.708 |
CSK |
0.687 | -0.090 | 2 | 0.764 |
IGF1R |
0.687 | -0.089 | 3 | 0.156 |
PTK6 |
0.686 | -0.160 | -1 | 0.639 |
EPHA1 |
0.686 | -0.165 | 3 | 0.157 |
NEK10_TYR |
0.686 | -0.167 | 1 | 0.643 |
MATK |
0.684 | -0.112 | -1 | 0.678 |
NTRK3 |
0.683 | -0.143 | -1 | 0.682 |
NTRK2 |
0.682 | -0.216 | 3 | 0.180 |
JAK1 |
0.681 | -0.222 | 1 | 0.693 |
PDGFRA |
0.679 | -0.297 | 3 | 0.187 |
TNNI3K_TYR |
0.678 | -0.221 | 1 | 0.768 |
FES |
0.675 | -0.080 | -1 | 0.640 |
ZAP70 |
0.671 | -0.008 | -1 | 0.717 |
MUSK |
0.661 | -0.170 | 1 | 0.622 |