Motif 625 (n=168)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1V8 | PPAN-P2RY11 | S228 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| A0A0B4J1V8 | PPAN-P2RY11 | S368 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| B5ME19 | EIF3CL | S166 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| B5ME19 | EIF3CL | S530 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| O14647 | CHD2 | S156 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O15013 | ARHGEF10 | S1229 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15061 | SYNM | S913 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15117 | FYB1 | S445 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15117 | FYB1 | S457 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15151 | MDM4 | S342 | ochoa|psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15259 | NPHP1 | S126 | psp | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q9QY53}. |
| O60264 | SMARCA5 | S137 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60566 | BUB1B | S435 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60934 | NBN | S604 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75164 | KDM4A | S616 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75400 | PRPF40A | S723 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75717 | WDHD1 | S853 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O94880 | PHF14 | S91 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95218 | ZRANB2 | S143 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95831 | AIFM1 | S524 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P05198 | EIF2S1 | S161 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P07900 | HSP90AA1 | S231 | ochoa|psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08069 | IGF1R | S982 | psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P11021 | HSPA5 | S301 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11171 | EPB41 | S85 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P14618 | PKM | S269 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P17181 | IFNAR1 | S532 | psp | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}. |
| P17936 | IGFBP3 | S194 | psp | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| P22732 | SLC2A5 | S242 | ochoa | Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5) | Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}. |
| P29374 | ARID4A | S538 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30273 | FCER1G | S61 | ochoa | High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma) | Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. {ECO:0000250|UniProtKB:P20491}. |
| P30414 | NKTR | S906 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P33981 | TTK | S363 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | S1580 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P41162 | ETV3 | S182 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P41227 | NAA10 | S216 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P41236 | PPP1R2 | S77 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P42566 | EPS15 | S851 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42768 | WAS | S483 | ochoa|psp | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P46100 | ATRX | S871 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S875 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S891 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P51858 | HDGF | S165 | ochoa | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52739 | ZNF131 | S580 | ochoa | Zinc finger protein 131 | Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}. |
| P52948 | NUP98 | S746 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P78312 | FAM193A | S965 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78410 | BTN3A2 | S286 | ochoa | Butyrophilin subfamily 3 member A2 | Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}. |
| Q01538 | MYT1 | S94 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q02790 | FKBP4 | S430 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q05209 | PTPN12 | S670 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07864 | POLE | S1940 | ochoa|psp | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q12888 | TP53BP1 | S724 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13042 | CDC16 | S586 | ochoa | Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q13131 | PRKAA1 | S467 | psp | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13422 | IKZF1 | S289 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13488 | TCIRG1 | S691 | ochoa | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation (PubMed:10329006). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:10329006}. |
| Q13501 | SQSTM1 | S349 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13523 | PRP4K | S519 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q15149 | PLEC | S2578 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15435 | PPP1R7 | S47 | ochoa|psp | Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) | Regulatory subunit of protein phosphatase 1. {ECO:0000250}. |
| Q15678 | PTPN14 | S831 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q2KHR3 | QSER1 | S973 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2T9K0 | TMEM44 | S333 | ochoa | Transmembrane protein 44 | None |
| Q3V6T2 | CCDC88A | S1020 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5BKZ1 | ZNF326 | S478 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5F1R6 | DNAJC21 | S257 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5H9R7 | PPP6R3 | S825 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5QJE6 | DNTTIP2 | S82 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5UIP0 | RIF1 | S1089 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S2809 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5W0B1 | OBI1 | S438 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q63HQ0 | AP1AR | S198 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q641Q2 | WASHC2A | S213 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S529 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6UX04 | CWC27 | S250 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6UXH1 | CRELD2 | S71 | ochoa | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q6WKZ4 | RAB11FIP1 | S501 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6Y7W6 | GIGYF2 | S189 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZUJ8 | PIK3AP1 | S145 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q70Z53 | FRA10AC1 | S273 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q71F23 | CENPU | S53 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z3K6 | MIER3 | S146 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z417 | NUFIP2 | S607 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z739 | YTHDF3 | S558 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q7Z7L1 | SLFN11 | S753 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86U86 | PBRM1 | S1119 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UE4 | MTDH | S180 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86VP1 | TAX1BP1 | S683 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86W56 | PARG | S286 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86X95 | CIR1 | S196 | ochoa | Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) | May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}. |
| Q86XL3 | ANKLE2 | S778 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IV38 | ANKMY2 | S403 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8IX03 | WWC1 | S833 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IY18 | SMC5 | S506 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8N0Z3 | SPICE1 | S329 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8NC51 | SERBP1 | S247 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NEF9 | SRFBP1 | S242 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8TAD8 | SNIP1 | S374 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TAF3 | WDR48 | S611 | ochoa | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. |
| Q8TAQ2 | SMARCC2 | S738 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TAQ2 | SMARCC2 | S813 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TCU6 | PREX1 | S1159 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8WVC0 | LEO1 | S179 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WYP5 | AHCTF1 | S1513 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92667 | AKAP1 | S309 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q96A65 | EXOC4 | S32 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96AJ1 | CLUAP1 | S314 | ochoa | Clusterin-associated protein 1 (Qilin) | Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}. |
| Q96C86 | DCPS | S72 | ochoa | m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172, ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679, ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270, ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. |
| Q96DX7 | TRIM44 | S320 | ochoa | Tripartite motif-containing protein 44 (Protein DIPB) | May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}. |
| Q96ER3 | SAAL1 | S55 | ochoa | Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1) | Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli. {ECO:0000269|PubMed:22127701}. |
| Q96F46 | IL17RA | S801 | ochoa|psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96GN5 | CDCA7L | S108 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96LR5 | UBE2E2 | S19 | ochoa | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:9371400}. |
| Q96Q89 | KIF20B | S525 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96T23 | RSF1 | S218 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99549 | MPHOSPH8 | S267 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99613 | EIF3C | S166 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99613 | EIF3C | S529 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q9BTC0 | DIDO1 | S890 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUL5 | PHF23 | S305 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BXK5 | BCL2L13 | S298 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXS6 | NUSAP1 | S63 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BXW6 | OSBPL1A | S490 | ochoa | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}. |
| Q9BXW9 | FANCD2 | S1418 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BYJ9 | YTHDF1 | S531 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9BYW2 | SETD2 | S1888 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZE4 | GTPBP4 | S300 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9C005 | DPY30 | S19 | ochoa | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| Q9H2M9 | RAB3GAP2 | S41 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
| Q9H501 | ESF1 | S228 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9HAF1 | MEAF6 | S125 | ochoa | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}. |
| Q9HB65 | ELL3 | T245 | ochoa | RNA polymerase II elongation factor ELL3 | Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). {ECO:0000250, ECO:0000269|PubMed:10882741, ECO:0000269|PubMed:22195968}. |
| Q9HC77 | CPAP | S556 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQ55 | PPAN | S228 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NQ55 | PPAN | S368 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NQW6 | ANLN | S536 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRF9 | POLE3 | S122 | ochoa | DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000250|UniProtKB:Q04603, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:14759371}. |
| Q9NV79 | PCMTD2 | S306 | ochoa | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 | May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity. {ECO:0000250|UniProtKB:Q96MG8}. |
| Q9NVE7 | PANK4 | S63 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NWC5 | TMEM45A | S257 | ochoa | Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) | None |
| Q9P0K7 | RAI14 | S478 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0P8 | MTRES1 | S106 | ochoa | Mitochondrial transcription rescue factor 1 | Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:31396629, PubMed:33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629, ECO:0000269|PubMed:33243891}. |
| Q9P0P8 | MTRES1 | S110 | ochoa | Mitochondrial transcription rescue factor 1 | Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:31396629, PubMed:33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629, ECO:0000269|PubMed:33243891}. |
| Q9UBU7 | DBF4 | S381 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UHR5 | SAP30BP | S52 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UJA5 | TRMT6 | S288 | ochoa | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}. |
| Q9UK61 | TASOR | S800 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKS6 | PACSIN3 | S383 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9ULI0 | ATAD2B | S1321 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULT8 | HECTD1 | S632 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UNF0 | PACSIN2 | S446 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9Y266 | NUDC | S100 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y266 | NUDC | S136 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y2X3 | NOP58 | S440 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y496 | KIF3A | S381 | ochoa | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}. |
| Q9Y5B6 | PAXBP1 | S295 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5B6 | PAXBP1 | S564 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5U5 | TNFRSF18 | S211 | ochoa | Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| O43707 | ACTN4 | S511 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| Q15906 | VPS72 | S41 | ELM | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q13509 | TUBB3 | S420 | GPS6|ELM|EPSD | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q00987 | MDM2 | S342 | PSP | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q9Y696 | CLIC4 | S226 | Sugiyama | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
| Q8TEQ6 | GEMIN5 | S1396 | Sugiyama | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| P61244 | MAX | S132 | iPTMNet | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| O75116 | ROCK2 | S873 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O14893 | GEMIN2 | S126 | Sugiyama | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
| Q9P0L2 | MARK1 | S435 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 2.878574e-08 | 7.541 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.124766e-05 | 4.213 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.180997e-05 | 4.087 |
| R-HSA-191859 | snRNP Assembly | 8.966595e-04 | 3.047 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.966595e-04 | 3.047 |
| R-HSA-3371556 | Cellular response to heat stress | 7.560230e-04 | 3.121 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.957552e-04 | 3.158 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.457678e-03 | 2.836 |
| R-HSA-68886 | M Phase | 1.649634e-03 | 2.783 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.239098e-03 | 2.650 |
| R-HSA-68877 | Mitotic Prometaphase | 2.408262e-03 | 2.618 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.863487e-03 | 2.543 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.472267e-03 | 2.349 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 7.371280e-03 | 2.132 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 7.940091e-03 | 2.100 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 7.940091e-03 | 2.100 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 9.153548e-03 | 2.038 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 9.153548e-03 | 2.038 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 9.798645e-03 | 2.009 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.859738e-03 | 2.413 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.859738e-03 | 2.413 |
| R-HSA-5693606 | DNA Double Strand Break Response | 9.466502e-03 | 2.024 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.442727e-03 | 2.191 |
| R-HSA-68962 | Activation of the pre-replicative complex | 7.371280e-03 | 2.132 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.015165e-03 | 2.396 |
| R-HSA-68952 | DNA replication initiation | 9.045206e-03 | 2.044 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.230295e-03 | 2.085 |
| R-HSA-68882 | Mitotic Anaphase | 4.571496e-03 | 2.340 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.686273e-03 | 2.329 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 5.342737e-03 | 2.272 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 9.798645e-03 | 2.009 |
| R-HSA-5617833 | Cilium Assembly | 8.311418e-03 | 2.080 |
| R-HSA-73894 | DNA Repair | 9.112916e-03 | 2.040 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.817470e-03 | 2.418 |
| R-HSA-4839726 | Chromatin organization | 9.674497e-03 | 2.014 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.997111e-03 | 2.155 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 7.371280e-03 | 2.132 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.237118e-03 | 2.140 |
| R-HSA-70171 | Glycolysis | 7.657448e-03 | 2.116 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.494971e-03 | 2.071 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.100276e-03 | 2.215 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.116658e-02 | 1.952 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.421807e-02 | 1.847 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.504749e-02 | 1.823 |
| R-HSA-3371568 | Attenuation phase | 1.504749e-02 | 1.823 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.188978e-02 | 1.925 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.421807e-02 | 1.847 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.341394e-02 | 1.872 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.263933e-02 | 1.898 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.376018e-02 | 1.861 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.046959e-02 | 1.980 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.504749e-02 | 1.823 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.504749e-02 | 1.823 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.187321e-02 | 1.925 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.503654e-02 | 1.823 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.341539e-02 | 1.872 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.421807e-02 | 1.847 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.503654e-02 | 1.823 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.225521e-02 | 1.912 |
| R-HSA-70326 | Glucose metabolism | 1.477568e-02 | 1.830 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.673908e-02 | 1.776 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.611442e-02 | 1.793 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.673908e-02 | 1.776 |
| R-HSA-73886 | Chromosome Maintenance | 1.659791e-02 | 1.780 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.590375e-02 | 1.799 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.590375e-02 | 1.799 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.150190e-02 | 1.668 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.150190e-02 | 1.668 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.150190e-02 | 1.668 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.150190e-02 | 1.668 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.150190e-02 | 1.668 |
| R-HSA-774815 | Nucleosome assembly | 2.059005e-02 | 1.686 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.059005e-02 | 1.686 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.059005e-02 | 1.686 |
| R-HSA-2262752 | Cellular responses to stress | 1.861069e-02 | 1.730 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.066089e-02 | 1.685 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.160865e-02 | 1.665 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.230748e-02 | 1.652 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.230748e-02 | 1.652 |
| R-HSA-5620924 | Intraflagellar transport | 2.372734e-02 | 1.625 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.372734e-02 | 1.625 |
| R-HSA-73893 | DNA Damage Bypass | 2.482742e-02 | 1.605 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.638548e-02 | 1.579 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.638548e-02 | 1.579 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.710897e-02 | 1.567 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.073956e-02 | 1.512 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.199644e-02 | 1.495 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.861232e-02 | 1.543 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.301586e-02 | 1.481 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.254405e-02 | 1.371 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.254405e-02 | 1.371 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.254405e-02 | 1.371 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.254405e-02 | 1.371 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.254405e-02 | 1.371 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.254405e-02 | 1.371 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.254405e-02 | 1.371 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.254405e-02 | 1.371 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.254405e-02 | 1.371 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.254405e-02 | 1.371 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.254405e-02 | 1.371 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.535611e-02 | 1.452 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.013003e-02 | 1.397 |
| R-HSA-983189 | Kinesins | 3.870827e-02 | 1.412 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 4.254405e-02 | 1.371 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.460135e-02 | 1.461 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.157799e-02 | 1.381 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.744838e-02 | 1.427 |
| R-HSA-211000 | Gene Silencing by RNA | 4.179739e-02 | 1.379 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.072711e-02 | 1.390 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.906666e-02 | 1.408 |
| R-HSA-373755 | Semaphorin interactions | 4.305202e-02 | 1.366 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.395745e-02 | 1.357 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.532440e-02 | 1.344 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.532440e-02 | 1.344 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.532440e-02 | 1.344 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.605660e-02 | 1.337 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.796047e-02 | 1.319 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.920602e-02 | 1.308 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.962756e-02 | 1.304 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.966694e-02 | 1.304 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 5.065112e-02 | 1.295 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.289578e-02 | 1.277 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.289578e-02 | 1.277 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.289578e-02 | 1.277 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.339486e-02 | 1.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.080824e-02 | 1.294 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.919331e-02 | 1.228 |
| R-HSA-5693538 | Homology Directed Repair | 5.693838e-02 | 1.245 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 6.487218e-02 | 1.188 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.903585e-02 | 1.229 |
| R-HSA-182971 | EGFR downregulation | 6.193029e-02 | 1.208 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 5.619024e-02 | 1.250 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.903585e-02 | 1.229 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.746703e-02 | 1.241 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.919331e-02 | 1.228 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.076863e-02 | 1.294 |
| R-HSA-69206 | G1/S Transition | 6.753526e-02 | 1.170 |
| R-HSA-74160 | Gene expression (Transcription) | 6.145559e-02 | 1.211 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.271848e-02 | 1.203 |
| R-HSA-9679506 | SARS-CoV Infections | 5.100336e-02 | 1.292 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 6.786017e-02 | 1.168 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.786017e-02 | 1.168 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.818471e-02 | 1.166 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.818471e-02 | 1.166 |
| R-HSA-69481 | G2/M Checkpoints | 7.033382e-02 | 1.153 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.396916e-02 | 1.131 |
| R-HSA-5696400 | Dual Incision in GG-NER | 7.396916e-02 | 1.131 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 7.396916e-02 | 1.131 |
| R-HSA-69275 | G2/M Transition | 7.428430e-02 | 1.129 |
| R-HSA-1500931 | Cell-Cell communication | 7.548284e-02 | 1.122 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.579745e-02 | 1.120 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.669052e-02 | 1.115 |
| R-HSA-381042 | PERK regulates gene expression | 7.708759e-02 | 1.113 |
| R-HSA-2559585 | Oncogene Induced Senescence | 7.708759e-02 | 1.113 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.908095e-02 | 1.102 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.920349e-02 | 1.101 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.030087e-01 | 0.987 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.127103e-01 | 0.948 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.596754e-01 | 0.797 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.687675e-01 | 0.773 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.687675e-01 | 0.773 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.866593e-01 | 0.729 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.954610e-01 | 0.709 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.954610e-01 | 0.709 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.127814e-01 | 0.672 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.127814e-01 | 0.672 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.297310e-01 | 0.639 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.297310e-01 | 0.639 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.380693e-01 | 0.623 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.380693e-01 | 0.623 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.380693e-01 | 0.623 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.380693e-01 | 0.623 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.380693e-01 | 0.623 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.173625e-01 | 0.930 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.390999e-01 | 0.857 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.428042e-01 | 0.845 |
| R-HSA-72649 | Translation initiation complex formation | 1.465294e-01 | 0.834 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.502746e-01 | 0.823 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.540389e-01 | 0.812 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.540389e-01 | 0.812 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.540389e-01 | 0.812 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.997199e-02 | 1.046 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.808548e-01 | 0.743 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.808548e-01 | 0.743 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.925544e-01 | 0.715 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.201957e-01 | 0.657 |
| R-HSA-380287 | Centrosome maturation | 2.281580e-01 | 0.642 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.421199e-02 | 1.026 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.504845e-01 | 0.823 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.122581e-01 | 0.673 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.122581e-01 | 0.673 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.127814e-01 | 0.672 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.380693e-01 | 0.623 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.138299e-01 | 0.944 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.213021e-01 | 0.655 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.596754e-01 | 0.797 |
| R-HSA-3371511 | HSF1 activation | 8.024694e-02 | 1.096 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.502746e-01 | 0.823 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.027275e-01 | 0.693 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.718785e-01 | 0.765 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.260455e-01 | 0.899 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.320167e-02 | 1.031 |
| R-HSA-192905 | vRNP Assembly | 1.411936e-01 | 0.850 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.504845e-01 | 0.823 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.127814e-01 | 0.672 |
| R-HSA-69541 | Stabilization of p53 | 8.995831e-02 | 1.046 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.866593e-01 | 0.729 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.596754e-01 | 0.797 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.122581e-01 | 0.673 |
| R-HSA-9646399 | Aggrephagy | 9.326923e-02 | 1.030 |
| R-HSA-9766229 | Degradation of CDH1 | 1.281208e-01 | 0.892 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.769796e-01 | 0.752 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.687675e-01 | 0.773 |
| R-HSA-72172 | mRNA Splicing | 2.276405e-01 | 0.643 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.769796e-01 | 0.752 |
| R-HSA-8981373 | Intestinal hexose absorption | 8.328800e-02 | 1.079 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.866593e-01 | 0.729 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.213021e-01 | 0.655 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.297310e-01 | 0.639 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.616214e-01 | 0.792 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.281208e-01 | 0.892 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.281208e-01 | 0.892 |
| R-HSA-9664873 | Pexophagy | 1.318017e-01 | 0.880 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.777618e-01 | 0.750 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.616214e-01 | 0.792 |
| R-HSA-9612973 | Autophagy | 1.227260e-01 | 0.911 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.213021e-01 | 0.655 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.318017e-01 | 0.880 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.390999e-01 | 0.857 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.578214e-01 | 0.802 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.241741e-01 | 0.649 |
| R-HSA-9609690 | HCMV Early Events | 2.071954e-01 | 0.684 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.281580e-01 | 0.642 |
| R-HSA-9663891 | Selective autophagy | 8.997199e-02 | 1.046 |
| R-HSA-5635838 | Activation of SMO | 1.954610e-01 | 0.709 |
| R-HSA-1632852 | Macroautophagy | 9.479845e-02 | 1.023 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.692704e-01 | 0.771 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.208861e-01 | 0.918 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.808548e-01 | 0.743 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.030087e-01 | 0.987 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.223076e-01 | 0.913 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.504845e-01 | 0.823 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.380693e-01 | 0.623 |
| R-HSA-2559583 | Cellular Senescence | 1.723365e-01 | 0.764 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 9.661510e-02 | 1.015 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.119614e-01 | 0.951 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.189250e-01 | 0.925 |
| R-HSA-202433 | Generation of second messenger molecules | 9.326923e-02 | 1.030 |
| R-HSA-8963676 | Intestinal absorption | 1.127103e-01 | 0.948 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.223076e-01 | 0.913 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.041681e-01 | 0.690 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.127814e-01 | 0.672 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.465294e-01 | 0.834 |
| R-HSA-199991 | Membrane Trafficking | 1.939033e-01 | 0.712 |
| R-HSA-8852135 | Protein ubiquitination | 2.281580e-01 | 0.642 |
| R-HSA-8953854 | Metabolism of RNA | 2.224375e-01 | 0.653 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.540389e-01 | 0.812 |
| R-HSA-177929 | Signaling by EGFR | 1.540389e-01 | 0.812 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.122581e-01 | 0.673 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.103258e-01 | 0.957 |
| R-HSA-913531 | Interferon Signaling | 1.526409e-01 | 0.816 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.533824e-01 | 0.814 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.223076e-01 | 0.913 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.866593e-01 | 0.729 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.162159e-01 | 0.665 |
| R-HSA-69306 | DNA Replication | 1.172428e-01 | 0.931 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.316541e-01 | 0.881 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.618986e-01 | 0.791 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.411936e-01 | 0.850 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.596754e-01 | 0.797 |
| R-HSA-8876725 | Protein methylation | 1.866593e-01 | 0.729 |
| R-HSA-168255 | Influenza Infection | 1.702302e-01 | 0.769 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.223076e-01 | 0.913 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.777618e-01 | 0.750 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.692704e-01 | 0.771 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.905395e-01 | 0.720 |
| R-HSA-73887 | Death Receptor Signaling | 1.190584e-01 | 0.924 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.577906e-01 | 0.802 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.577906e-01 | 0.802 |
| R-HSA-446728 | Cell junction organization | 2.249910e-01 | 0.648 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.380693e-01 | 0.623 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.380693e-01 | 0.623 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.048848e-01 | 0.979 |
| R-HSA-373753 | Nephrin family interactions | 2.380693e-01 | 0.623 |
| R-HSA-73884 | Base Excision Repair | 9.421199e-02 | 1.026 |
| R-HSA-69239 | Synthesis of DNA | 1.407290e-01 | 0.852 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 9.661510e-02 | 1.015 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.083001e-01 | 0.681 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.213021e-01 | 0.655 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.071954e-01 | 0.684 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.407290e-01 | 0.852 |
| R-HSA-68875 | Mitotic Prophase | 1.796893e-01 | 0.745 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.407290e-01 | 0.852 |
| R-HSA-69242 | S Phase | 1.083521e-01 | 0.965 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.834415e-02 | 1.054 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.281580e-01 | 0.642 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.390999e-01 | 0.857 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.878111e-01 | 0.726 |
| R-HSA-381070 | IRE1alpha activates chaperones | 9.853292e-02 | 1.006 |
| R-HSA-72306 | tRNA processing | 1.517039e-01 | 0.819 |
| R-HSA-2028269 | Signaling by Hippo | 2.127814e-01 | 0.672 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.406589e-01 | 0.852 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.463177e-01 | 0.609 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.463177e-01 | 0.609 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.469172e-01 | 0.607 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.481410e-01 | 0.605 |
| R-HSA-9833482 | PKR-mediated signaling | 2.481410e-01 | 0.605 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.521465e-01 | 0.598 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.527044e-01 | 0.597 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.544774e-01 | 0.594 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.544774e-01 | 0.594 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.544774e-01 | 0.594 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.544774e-01 | 0.594 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.556055e-01 | 0.592 |
| R-HSA-418990 | Adherens junctions interactions | 2.603832e-01 | 0.584 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.625493e-01 | 0.581 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.625493e-01 | 0.581 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.641714e-01 | 0.578 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.641714e-01 | 0.578 |
| R-HSA-1500620 | Meiosis | 2.681808e-01 | 0.572 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.705342e-01 | 0.568 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.705342e-01 | 0.568 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.705342e-01 | 0.568 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.761986e-01 | 0.559 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.784332e-01 | 0.555 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.784332e-01 | 0.555 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 2.784332e-01 | 0.555 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.802061e-01 | 0.553 |
| R-HSA-70268 | Pyruvate metabolism | 2.802061e-01 | 0.553 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.862471e-01 | 0.543 |
| R-HSA-3214842 | HDMs demethylate histones | 2.862471e-01 | 0.543 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.862471e-01 | 0.543 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.919250e-01 | 0.535 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.939769e-01 | 0.532 |
| R-HSA-9610379 | HCMV Late Events | 2.966228e-01 | 0.528 |
| R-HSA-162587 | HIV Life Cycle | 2.966228e-01 | 0.528 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.016234e-01 | 0.521 |
| R-HSA-264876 | Insulin processing | 3.016234e-01 | 0.521 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.042030e-01 | 0.517 |
| R-HSA-77387 | Insulin receptor recycling | 3.091876e-01 | 0.510 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.091876e-01 | 0.510 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.091876e-01 | 0.510 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.150509e-01 | 0.502 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.161527e-01 | 0.500 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.166703e-01 | 0.499 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.166703e-01 | 0.499 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.240725e-01 | 0.489 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.240725e-01 | 0.489 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.240725e-01 | 0.489 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.240725e-01 | 0.489 |
| R-HSA-5619102 | SLC transporter disorders | 3.261777e-01 | 0.487 |
| R-HSA-168256 | Immune System | 3.277289e-01 | 0.484 |
| R-HSA-157579 | Telomere Maintenance | 3.280562e-01 | 0.484 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.313949e-01 | 0.480 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.313949e-01 | 0.480 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.313949e-01 | 0.480 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.313949e-01 | 0.480 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.313949e-01 | 0.480 |
| R-HSA-3214847 | HATs acetylate histones | 3.359616e-01 | 0.474 |
| R-HSA-9609646 | HCMV Infection | 3.379073e-01 | 0.471 |
| R-HSA-1538133 | G0 and Early G1 | 3.386384e-01 | 0.470 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.386384e-01 | 0.470 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.399043e-01 | 0.469 |
| R-HSA-421270 | Cell-cell junction organization | 3.403608e-01 | 0.468 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.438398e-01 | 0.464 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.458039e-01 | 0.461 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.458039e-01 | 0.461 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.458039e-01 | 0.461 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.458039e-01 | 0.461 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.458039e-01 | 0.461 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.458039e-01 | 0.461 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.458039e-01 | 0.461 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.468782e-01 | 0.460 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.477679e-01 | 0.459 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.477679e-01 | 0.459 |
| R-HSA-212436 | Generic Transcription Pathway | 3.492247e-01 | 0.457 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.498321e-01 | 0.456 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.528922e-01 | 0.452 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.528922e-01 | 0.452 |
| R-HSA-9833110 | RSV-host interactions | 3.595047e-01 | 0.444 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.599041e-01 | 0.444 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.599041e-01 | 0.444 |
| R-HSA-203615 | eNOS activation | 3.599041e-01 | 0.444 |
| R-HSA-190861 | Gap junction assembly | 3.599041e-01 | 0.444 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.599041e-01 | 0.444 |
| R-HSA-5205647 | Mitophagy | 3.599041e-01 | 0.444 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.634002e-01 | 0.440 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.651183e-01 | 0.438 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.668405e-01 | 0.436 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.668405e-01 | 0.436 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.668405e-01 | 0.436 |
| R-HSA-9824446 | Viral Infection Pathways | 3.673479e-01 | 0.435 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.737022e-01 | 0.427 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.750324e-01 | 0.426 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.750324e-01 | 0.426 |
| R-HSA-1280218 | Adaptive Immune System | 3.762510e-01 | 0.425 |
| R-HSA-202403 | TCR signaling | 3.827396e-01 | 0.417 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.872044e-01 | 0.412 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.872044e-01 | 0.412 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.872044e-01 | 0.412 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.938466e-01 | 0.405 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.938466e-01 | 0.405 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.004172e-01 | 0.397 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.004172e-01 | 0.397 |
| R-HSA-449147 | Signaling by Interleukins | 4.043726e-01 | 0.393 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.069170e-01 | 0.390 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.069170e-01 | 0.390 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.093847e-01 | 0.388 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.131464e-01 | 0.384 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.131464e-01 | 0.384 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.133467e-01 | 0.384 |
| R-HSA-165159 | MTOR signalling | 4.197071e-01 | 0.377 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.206342e-01 | 0.376 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.317744e-01 | 0.365 |
| R-HSA-190828 | Gap junction trafficking | 4.322230e-01 | 0.364 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.322230e-01 | 0.364 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.383799e-01 | 0.358 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.444704e-01 | 0.352 |
| R-HSA-9675135 | Diseases of DNA repair | 4.444704e-01 | 0.352 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.444704e-01 | 0.352 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.444704e-01 | 0.352 |
| R-HSA-75153 | Apoptotic execution phase | 4.444704e-01 | 0.352 |
| R-HSA-194138 | Signaling by VEGF | 4.500861e-01 | 0.347 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.504952e-01 | 0.346 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.504952e-01 | 0.346 |
| R-HSA-437239 | Recycling pathway of L1 | 4.504952e-01 | 0.346 |
| R-HSA-114608 | Platelet degranulation | 4.573180e-01 | 0.340 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.623507e-01 | 0.335 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.625965e-01 | 0.335 |
| R-HSA-1474165 | Reproduction | 4.716165e-01 | 0.326 |
| R-HSA-912446 | Meiotic recombination | 4.739518e-01 | 0.324 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.796586e-01 | 0.319 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.796586e-01 | 0.319 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.796586e-01 | 0.319 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.796586e-01 | 0.319 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.821922e-01 | 0.317 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.853039e-01 | 0.314 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.853039e-01 | 0.314 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.853039e-01 | 0.314 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.853039e-01 | 0.314 |
| R-HSA-1221632 | Meiotic synapsis | 4.853039e-01 | 0.314 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.908884e-01 | 0.309 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.960901e-01 | 0.304 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.964125e-01 | 0.304 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.018771e-01 | 0.299 |
| R-HSA-75893 | TNF signaling | 5.018771e-01 | 0.299 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.029503e-01 | 0.298 |
| R-HSA-162906 | HIV Infection | 5.038183e-01 | 0.298 |
| R-HSA-5621480 | Dectin-2 family | 5.072827e-01 | 0.295 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.072827e-01 | 0.295 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.097504e-01 | 0.293 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.097504e-01 | 0.293 |
| R-HSA-9664407 | Parasite infection | 5.097504e-01 | 0.293 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.126299e-01 | 0.290 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.126299e-01 | 0.290 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.179195e-01 | 0.286 |
| R-HSA-180786 | Extension of Telomeres | 5.179195e-01 | 0.286 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.179195e-01 | 0.286 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.231520e-01 | 0.281 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.283280e-01 | 0.277 |
| R-HSA-8939211 | ESR-mediated signaling | 5.303900e-01 | 0.275 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.334481e-01 | 0.273 |
| R-HSA-186797 | Signaling by PDGF | 5.334481e-01 | 0.273 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.363392e-01 | 0.271 |
| R-HSA-157118 | Signaling by NOTCH | 5.382074e-01 | 0.269 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.385130e-01 | 0.269 |
| R-HSA-8963743 | Digestion and absorption | 5.385130e-01 | 0.269 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.435232e-01 | 0.265 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.484793e-01 | 0.261 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.492601e-01 | 0.260 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.533819e-01 | 0.257 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.533819e-01 | 0.257 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.561585e-01 | 0.255 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.630289e-01 | 0.249 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.630289e-01 | 0.249 |
| R-HSA-5218859 | Regulated Necrosis | 5.630289e-01 | 0.249 |
| R-HSA-9711097 | Cellular response to starvation | 5.712623e-01 | 0.243 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.724687e-01 | 0.242 |
| R-HSA-448424 | Interleukin-17 signaling | 5.724687e-01 | 0.242 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.724687e-01 | 0.242 |
| R-HSA-5688426 | Deubiquitination | 5.761607e-01 | 0.239 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.771123e-01 | 0.239 |
| R-HSA-8978934 | Metabolism of cofactors | 5.771123e-01 | 0.239 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.771123e-01 | 0.239 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.817057e-01 | 0.235 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.862495e-01 | 0.232 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.907442e-01 | 0.229 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.907442e-01 | 0.229 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.922924e-01 | 0.227 |
| R-HSA-917937 | Iron uptake and transport | 5.951904e-01 | 0.225 |
| R-HSA-6798695 | Neutrophil degranulation | 5.960119e-01 | 0.225 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.001931e-01 | 0.222 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.039392e-01 | 0.219 |
| R-HSA-9659379 | Sensory processing of sound | 6.125000e-01 | 0.213 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.157676e-01 | 0.211 |
| R-HSA-6806834 | Signaling by MET | 6.167111e-01 | 0.210 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.213666e-01 | 0.207 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.249973e-01 | 0.204 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.290734e-01 | 0.201 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.370939e-01 | 0.196 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.394003e-01 | 0.194 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.410392e-01 | 0.193 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.410392e-01 | 0.193 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.419823e-01 | 0.192 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.449419e-01 | 0.190 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.488023e-01 | 0.188 |
| R-HSA-597592 | Post-translational protein modification | 6.581650e-01 | 0.182 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.695135e-01 | 0.174 |
| R-HSA-391251 | Protein folding | 6.711043e-01 | 0.173 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.711043e-01 | 0.173 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.746819e-01 | 0.171 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.746819e-01 | 0.171 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.782208e-01 | 0.169 |
| R-HSA-1474290 | Collagen formation | 6.782208e-01 | 0.169 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.851842e-01 | 0.164 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.886094e-01 | 0.162 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.886094e-01 | 0.162 |
| R-HSA-5663205 | Infectious disease | 6.886583e-01 | 0.162 |
| R-HSA-162582 | Signal Transduction | 6.890899e-01 | 0.162 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.892569e-01 | 0.162 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.900317e-01 | 0.161 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.919977e-01 | 0.160 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.940397e-01 | 0.159 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.953492e-01 | 0.158 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.986645e-01 | 0.156 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.019440e-01 | 0.154 |
| R-HSA-5357801 | Programmed Cell Death | 7.034241e-01 | 0.153 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.051879e-01 | 0.152 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.115708e-01 | 0.148 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.147106e-01 | 0.146 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.147106e-01 | 0.146 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.178163e-01 | 0.144 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.178163e-01 | 0.144 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.223073e-01 | 0.141 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.357575e-01 | 0.133 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.414821e-01 | 0.130 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.498386e-01 | 0.125 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.525640e-01 | 0.123 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.552598e-01 | 0.122 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.552598e-01 | 0.122 |
| R-HSA-373760 | L1CAM interactions | 7.579265e-01 | 0.120 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.605642e-01 | 0.119 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.605642e-01 | 0.119 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.758013e-01 | 0.110 |
| R-HSA-109582 | Hemostasis | 7.762803e-01 | 0.110 |
| R-HSA-112316 | Neuronal System | 7.807285e-01 | 0.107 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.830543e-01 | 0.106 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.830543e-01 | 0.106 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.830543e-01 | 0.106 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.946277e-01 | 0.100 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.033432e-01 | 0.095 |
| R-HSA-5368287 | Mitochondrial translation | 8.159648e-01 | 0.088 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.220460e-01 | 0.085 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.295745e-01 | 0.081 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.404403e-01 | 0.075 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.404403e-01 | 0.075 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.405025e-01 | 0.075 |
| R-HSA-9658195 | Leishmania infection | 8.405025e-01 | 0.075 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.472987e-01 | 0.072 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.538638e-01 | 0.069 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.584351e-01 | 0.066 |
| R-HSA-109581 | Apoptosis | 8.601483e-01 | 0.065 |
| R-HSA-1643685 | Disease | 8.637060e-01 | 0.064 |
| R-HSA-422475 | Axon guidance | 8.663958e-01 | 0.062 |
| R-HSA-72766 | Translation | 8.694641e-01 | 0.061 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.733229e-01 | 0.059 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.747083e-01 | 0.058 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.774341e-01 | 0.057 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.774341e-01 | 0.057 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.902037e-01 | 0.051 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.960832e-01 | 0.048 |
| R-HSA-9675108 | Nervous system development | 8.962362e-01 | 0.048 |
| R-HSA-392499 | Metabolism of proteins | 8.969043e-01 | 0.047 |
| R-HSA-983712 | Ion channel transport | 8.972210e-01 | 0.047 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.051787e-01 | 0.043 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.060143e-01 | 0.043 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.119085e-01 | 0.040 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.219679e-01 | 0.035 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.227497e-01 | 0.035 |
| R-HSA-8951664 | Neddylation | 9.285583e-01 | 0.032 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.353131e-01 | 0.029 |
| R-HSA-72312 | rRNA processing | 9.367256e-01 | 0.028 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.394765e-01 | 0.027 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.401243e-01 | 0.027 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.548744e-01 | 0.020 |
| R-HSA-195721 | Signaling by WNT | 9.695131e-01 | 0.013 |
| R-HSA-8957322 | Metabolism of steroids | 9.771532e-01 | 0.010 |
| R-HSA-1474244 | Extracellular matrix organization | 9.788622e-01 | 0.009 |
| R-HSA-168249 | Innate Immune System | 9.821303e-01 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 9.927406e-01 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 9.966170e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.989566e-01 | 0.000 |
| R-HSA-1266738 | Developmental Biology | 9.999895e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999993e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.865 | 0.224 | 2 | 0.793 |
BMPR1B |
0.856 | 0.470 | 1 | 0.834 |
CDC7 |
0.854 | 0.209 | 1 | 0.908 |
MOS |
0.854 | 0.255 | 1 | 0.915 |
CLK3 |
0.852 | 0.195 | 1 | 0.796 |
TGFBR1 |
0.848 | 0.489 | -2 | 0.955 |
GRK1 |
0.847 | 0.214 | -2 | 0.728 |
PIM3 |
0.846 | 0.098 | -3 | 0.822 |
BMPR1A |
0.846 | 0.484 | 1 | 0.826 |
CAMK2G |
0.846 | 0.188 | 2 | 0.832 |
FAM20C |
0.844 | 0.166 | 2 | 0.621 |
TGFBR2 |
0.842 | 0.291 | -2 | 0.943 |
ALK2 |
0.842 | 0.502 | -2 | 0.942 |
IKKB |
0.842 | 0.008 | -2 | 0.703 |
ACVR2A |
0.841 | 0.411 | -2 | 0.947 |
CAMK2B |
0.841 | 0.240 | 2 | 0.822 |
IKKA |
0.841 | 0.114 | -2 | 0.718 |
NDR2 |
0.841 | 0.081 | -3 | 0.827 |
ACVR2B |
0.840 | 0.412 | -2 | 0.943 |
DSTYK |
0.839 | 0.097 | 2 | 0.812 |
GCN2 |
0.839 | 0.016 | 2 | 0.744 |
PRPK |
0.838 | -0.053 | -1 | 0.855 |
GRK6 |
0.838 | 0.183 | 1 | 0.826 |
ALK4 |
0.838 | 0.421 | -2 | 0.953 |
BMPR2 |
0.838 | 0.209 | -2 | 0.879 |
CK2A2 |
0.837 | 0.342 | 1 | 0.815 |
GRK7 |
0.836 | 0.199 | 1 | 0.745 |
PIM1 |
0.836 | 0.109 | -3 | 0.774 |
GRK5 |
0.835 | 0.043 | -3 | 0.845 |
NEK6 |
0.834 | 0.076 | -2 | 0.876 |
LATS2 |
0.833 | 0.112 | -5 | 0.703 |
ATR |
0.832 | 0.032 | 1 | 0.831 |
RAF1 |
0.832 | -0.114 | 1 | 0.807 |
PLK1 |
0.831 | 0.192 | -2 | 0.887 |
MAPKAPK2 |
0.831 | 0.106 | -3 | 0.723 |
CAMK1B |
0.831 | -0.028 | -3 | 0.826 |
CAMK2A |
0.831 | 0.192 | 2 | 0.838 |
ATM |
0.830 | 0.129 | 1 | 0.796 |
GRK4 |
0.829 | 0.060 | -2 | 0.823 |
TBK1 |
0.829 | -0.091 | 1 | 0.672 |
MTOR |
0.829 | -0.129 | 1 | 0.729 |
SRPK1 |
0.829 | 0.061 | -3 | 0.726 |
NEK7 |
0.828 | -0.020 | -3 | 0.800 |
PDHK4 |
0.828 | -0.239 | 1 | 0.811 |
KIS |
0.828 | 0.033 | 1 | 0.651 |
PRKD1 |
0.827 | 0.026 | -3 | 0.786 |
CDKL1 |
0.827 | -0.006 | -3 | 0.772 |
RSK2 |
0.827 | 0.035 | -3 | 0.745 |
ULK2 |
0.827 | -0.142 | 2 | 0.710 |
IKKE |
0.826 | -0.103 | 1 | 0.667 |
PLK3 |
0.825 | 0.152 | 2 | 0.726 |
MLK1 |
0.825 | -0.079 | 2 | 0.745 |
CAMK2D |
0.825 | 0.063 | -3 | 0.801 |
PKN3 |
0.825 | -0.034 | -3 | 0.792 |
CK2A1 |
0.825 | 0.289 | 1 | 0.792 |
TLK2 |
0.825 | 0.194 | 1 | 0.782 |
LATS1 |
0.824 | 0.134 | -3 | 0.834 |
NLK |
0.824 | -0.087 | 1 | 0.785 |
SRPK2 |
0.823 | 0.070 | -3 | 0.653 |
PDHK1 |
0.822 | -0.191 | 1 | 0.784 |
NDR1 |
0.822 | -0.044 | -3 | 0.816 |
NUAK2 |
0.822 | -0.037 | -3 | 0.812 |
MARK4 |
0.821 | -0.024 | 4 | 0.843 |
NIK |
0.821 | -0.116 | -3 | 0.850 |
CHAK2 |
0.821 | -0.079 | -1 | 0.833 |
SKMLCK |
0.821 | -0.055 | -2 | 0.714 |
PRKD2 |
0.820 | 0.004 | -3 | 0.745 |
HUNK |
0.820 | -0.078 | 2 | 0.688 |
ERK5 |
0.819 | -0.093 | 1 | 0.740 |
DLK |
0.819 | -0.102 | 1 | 0.778 |
SRPK3 |
0.818 | 0.050 | -3 | 0.701 |
BCKDK |
0.818 | -0.088 | -1 | 0.793 |
HIPK4 |
0.818 | -0.024 | 1 | 0.776 |
MST4 |
0.818 | -0.073 | 2 | 0.794 |
DAPK2 |
0.817 | -0.089 | -3 | 0.827 |
TSSK2 |
0.817 | -0.018 | -5 | 0.804 |
P90RSK |
0.817 | -0.018 | -3 | 0.740 |
MLK3 |
0.817 | -0.028 | 2 | 0.693 |
AMPKA1 |
0.817 | -0.048 | -3 | 0.827 |
CAMLCK |
0.817 | -0.103 | -2 | 0.725 |
PKCD |
0.816 | -0.031 | 2 | 0.739 |
CDKL5 |
0.816 | -0.035 | -3 | 0.759 |
ULK1 |
0.816 | -0.163 | -3 | 0.766 |
MAPKAPK3 |
0.816 | -0.030 | -3 | 0.752 |
ANKRD3 |
0.816 | -0.096 | 1 | 0.806 |
GRK2 |
0.815 | 0.046 | -2 | 0.726 |
ICK |
0.815 | -0.031 | -3 | 0.801 |
CDK1 |
0.815 | 0.036 | 1 | 0.607 |
RIPK3 |
0.814 | -0.199 | 3 | 0.623 |
P70S6KB |
0.814 | -0.051 | -3 | 0.770 |
CLK2 |
0.813 | 0.095 | -3 | 0.734 |
WNK1 |
0.813 | -0.142 | -2 | 0.720 |
MLK4 |
0.813 | -0.029 | 2 | 0.664 |
DNAPK |
0.812 | 0.106 | 1 | 0.711 |
RSK4 |
0.812 | 0.032 | -3 | 0.722 |
PKR |
0.812 | -0.034 | 1 | 0.811 |
CDK8 |
0.812 | -0.023 | 1 | 0.624 |
PRKX |
0.812 | 0.060 | -3 | 0.675 |
TSSK1 |
0.812 | -0.026 | -3 | 0.842 |
PKN2 |
0.811 | -0.124 | -3 | 0.815 |
TLK1 |
0.811 | 0.139 | -2 | 0.907 |
MLK2 |
0.811 | -0.166 | 2 | 0.747 |
MASTL |
0.811 | -0.296 | -2 | 0.753 |
AMPKA2 |
0.811 | -0.044 | -3 | 0.800 |
TTBK2 |
0.810 | -0.157 | 2 | 0.619 |
NEK9 |
0.810 | -0.199 | 2 | 0.753 |
CHK1 |
0.810 | 0.029 | -3 | 0.809 |
MEK1 |
0.808 | -0.103 | 2 | 0.771 |
RSK3 |
0.808 | -0.059 | -3 | 0.735 |
JNK3 |
0.808 | 0.026 | 1 | 0.619 |
BRSK1 |
0.808 | -0.009 | -3 | 0.763 |
MSK2 |
0.808 | -0.050 | -3 | 0.717 |
PKACG |
0.807 | -0.088 | -2 | 0.578 |
YSK4 |
0.807 | -0.116 | 1 | 0.714 |
PERK |
0.807 | 0.056 | -2 | 0.896 |
GRK3 |
0.807 | 0.065 | -2 | 0.695 |
PKACB |
0.807 | -0.002 | -2 | 0.514 |
PLK2 |
0.806 | 0.136 | -3 | 0.771 |
JNK2 |
0.806 | 0.031 | 1 | 0.584 |
IRE2 |
0.806 | -0.073 | 2 | 0.687 |
WNK3 |
0.806 | -0.308 | 1 | 0.767 |
AURC |
0.806 | -0.054 | -2 | 0.498 |
NUAK1 |
0.806 | -0.060 | -3 | 0.764 |
MSK1 |
0.805 | -0.014 | -3 | 0.727 |
CDK5 |
0.805 | 0.000 | 1 | 0.666 |
IRE1 |
0.805 | -0.150 | 1 | 0.760 |
DYRK2 |
0.805 | -0.019 | 1 | 0.679 |
CLK4 |
0.804 | 0.005 | -3 | 0.739 |
QSK |
0.804 | -0.041 | 4 | 0.816 |
PASK |
0.804 | 0.058 | -3 | 0.831 |
SMG1 |
0.804 | -0.029 | 1 | 0.788 |
NIM1 |
0.803 | -0.154 | 3 | 0.696 |
BRAF |
0.803 | -0.010 | -4 | 0.798 |
PAK1 |
0.803 | -0.110 | -2 | 0.626 |
VRK2 |
0.803 | -0.274 | 1 | 0.824 |
CAMK4 |
0.803 | -0.159 | -3 | 0.793 |
CK1E |
0.802 | 0.008 | -3 | 0.587 |
PKCB |
0.802 | -0.070 | 2 | 0.681 |
HRI |
0.802 | -0.025 | -2 | 0.894 |
CDK19 |
0.802 | -0.038 | 1 | 0.585 |
MARK3 |
0.802 | -0.021 | 4 | 0.769 |
SIK |
0.801 | -0.046 | -3 | 0.735 |
MARK2 |
0.801 | -0.026 | 4 | 0.734 |
CDK3 |
0.800 | 0.040 | 1 | 0.546 |
AURA |
0.800 | -0.059 | -2 | 0.493 |
PIM2 |
0.800 | -0.005 | -3 | 0.717 |
RIPK1 |
0.799 | -0.311 | 1 | 0.772 |
CDK2 |
0.799 | -0.034 | 1 | 0.679 |
MEKK3 |
0.799 | -0.138 | 1 | 0.744 |
MELK |
0.799 | -0.116 | -3 | 0.775 |
CDK7 |
0.799 | -0.060 | 1 | 0.648 |
PKCG |
0.798 | -0.108 | 2 | 0.679 |
P38G |
0.798 | 0.007 | 1 | 0.514 |
CDK18 |
0.798 | -0.013 | 1 | 0.573 |
PRKD3 |
0.798 | -0.075 | -3 | 0.706 |
GSK3A |
0.798 | 0.036 | 4 | 0.470 |
PLK4 |
0.797 | -0.101 | 2 | 0.561 |
QIK |
0.797 | -0.158 | -3 | 0.792 |
DRAK1 |
0.797 | -0.111 | 1 | 0.763 |
PKCA |
0.797 | -0.098 | 2 | 0.674 |
CLK1 |
0.797 | -0.006 | -3 | 0.712 |
MYLK4 |
0.797 | -0.091 | -2 | 0.618 |
P38B |
0.796 | -0.003 | 1 | 0.583 |
DCAMKL1 |
0.796 | -0.030 | -3 | 0.766 |
HIPK2 |
0.796 | 0.003 | 1 | 0.597 |
MARK1 |
0.796 | -0.034 | 4 | 0.794 |
AURB |
0.796 | -0.086 | -2 | 0.502 |
PHKG1 |
0.796 | -0.121 | -3 | 0.803 |
BRSK2 |
0.795 | -0.116 | -3 | 0.780 |
CDK13 |
0.795 | -0.061 | 1 | 0.616 |
ERK1 |
0.795 | -0.026 | 1 | 0.575 |
CK1D |
0.795 | 0.014 | -3 | 0.540 |
P38A |
0.794 | -0.044 | 1 | 0.654 |
PRP4 |
0.794 | -0.036 | -3 | 0.728 |
MEKK2 |
0.794 | -0.138 | 2 | 0.734 |
PKCH |
0.794 | -0.132 | 2 | 0.662 |
TAO3 |
0.794 | -0.075 | 1 | 0.738 |
PAK3 |
0.794 | -0.184 | -2 | 0.625 |
GAK |
0.794 | 0.019 | 1 | 0.811 |
MNK1 |
0.793 | -0.114 | -2 | 0.650 |
ERK2 |
0.793 | -0.052 | 1 | 0.618 |
CHAK1 |
0.793 | -0.229 | 2 | 0.674 |
CDK17 |
0.792 | -0.021 | 1 | 0.524 |
CAMK1G |
0.792 | -0.084 | -3 | 0.728 |
HIPK1 |
0.792 | -0.024 | 1 | 0.686 |
MNK2 |
0.792 | -0.147 | -2 | 0.636 |
ZAK |
0.792 | -0.183 | 1 | 0.706 |
PAK2 |
0.792 | -0.168 | -2 | 0.620 |
MEKK1 |
0.791 | -0.207 | 1 | 0.749 |
PKCZ |
0.791 | -0.166 | 2 | 0.698 |
PINK1 |
0.791 | -0.174 | 1 | 0.802 |
NEK5 |
0.790 | -0.147 | 1 | 0.782 |
AKT2 |
0.790 | -0.053 | -3 | 0.663 |
SSTK |
0.790 | -0.052 | 4 | 0.803 |
MEK5 |
0.789 | -0.323 | 2 | 0.750 |
CDK16 |
0.789 | 0.008 | 1 | 0.543 |
PKG2 |
0.789 | -0.103 | -2 | 0.505 |
DYRK4 |
0.789 | -0.007 | 1 | 0.603 |
NEK2 |
0.789 | -0.245 | 2 | 0.725 |
CK1G1 |
0.788 | -0.046 | -3 | 0.586 |
MST2 |
0.788 | -0.045 | 1 | 0.756 |
SGK3 |
0.788 | -0.093 | -3 | 0.741 |
P38D |
0.788 | 0.006 | 1 | 0.545 |
CAMK1D |
0.788 | -0.022 | -3 | 0.656 |
EEF2K |
0.787 | -0.002 | 3 | 0.753 |
JNK1 |
0.787 | 0.004 | 1 | 0.580 |
DYRK1A |
0.787 | -0.046 | 1 | 0.699 |
GSK3B |
0.787 | -0.033 | 4 | 0.458 |
DAPK3 |
0.786 | -0.034 | -3 | 0.777 |
CK1A2 |
0.786 | -0.012 | -3 | 0.540 |
DCAMKL2 |
0.786 | -0.078 | -3 | 0.777 |
NEK8 |
0.785 | -0.155 | 2 | 0.735 |
SNRK |
0.785 | -0.257 | 2 | 0.618 |
CDK12 |
0.785 | -0.069 | 1 | 0.586 |
MAPKAPK5 |
0.785 | -0.157 | -3 | 0.685 |
PKACA |
0.785 | -0.045 | -2 | 0.458 |
MST3 |
0.785 | -0.152 | 2 | 0.746 |
PAK6 |
0.784 | -0.122 | -2 | 0.548 |
TAK1 |
0.784 | -0.047 | 1 | 0.795 |
SMMLCK |
0.783 | -0.128 | -3 | 0.780 |
DYRK1B |
0.783 | -0.039 | 1 | 0.627 |
MPSK1 |
0.783 | -0.086 | 1 | 0.760 |
GCK |
0.782 | -0.096 | 1 | 0.753 |
CAMKK1 |
0.782 | -0.194 | -2 | 0.671 |
CDK9 |
0.781 | -0.100 | 1 | 0.617 |
TTK |
0.781 | 0.147 | -2 | 0.909 |
TAO2 |
0.780 | -0.164 | 2 | 0.779 |
DAPK1 |
0.780 | -0.047 | -3 | 0.755 |
WNK4 |
0.780 | -0.252 | -2 | 0.724 |
TTBK1 |
0.779 | -0.197 | 2 | 0.546 |
P70S6K |
0.778 | -0.101 | -3 | 0.677 |
CDK14 |
0.778 | -0.062 | 1 | 0.613 |
DYRK3 |
0.778 | -0.055 | 1 | 0.695 |
ERK7 |
0.778 | -0.064 | 2 | 0.473 |
IRAK4 |
0.777 | -0.255 | 1 | 0.750 |
PDHK3_TYR |
0.777 | 0.330 | 4 | 0.921 |
MST1 |
0.777 | -0.086 | 1 | 0.729 |
TNIK |
0.777 | -0.094 | 3 | 0.752 |
PKCT |
0.777 | -0.153 | 2 | 0.674 |
PHKG2 |
0.776 | -0.163 | -3 | 0.765 |
HIPK3 |
0.776 | -0.096 | 1 | 0.673 |
CAMKK2 |
0.776 | -0.203 | -2 | 0.656 |
AKT1 |
0.776 | -0.079 | -3 | 0.685 |
PDK1 |
0.774 | -0.191 | 1 | 0.746 |
CDK10 |
0.774 | -0.042 | 1 | 0.604 |
LKB1 |
0.774 | -0.199 | -3 | 0.786 |
MINK |
0.774 | -0.162 | 1 | 0.727 |
NEK11 |
0.773 | -0.317 | 1 | 0.732 |
VRK1 |
0.772 | -0.207 | 2 | 0.741 |
PDHK4_TYR |
0.772 | 0.233 | 2 | 0.826 |
HGK |
0.772 | -0.161 | 3 | 0.737 |
OSR1 |
0.772 | -0.034 | 2 | 0.723 |
MRCKA |
0.770 | -0.052 | -3 | 0.732 |
MAK |
0.770 | 0.007 | -2 | 0.615 |
PKCE |
0.770 | -0.099 | 2 | 0.659 |
SGK1 |
0.770 | -0.034 | -3 | 0.595 |
ALPHAK3 |
0.769 | 0.024 | -1 | 0.788 |
MAP2K6_TYR |
0.769 | 0.202 | -1 | 0.884 |
LRRK2 |
0.769 | -0.266 | 2 | 0.760 |
ROCK2 |
0.769 | -0.054 | -3 | 0.767 |
PDHK1_TYR |
0.768 | 0.186 | -1 | 0.909 |
CDK6 |
0.768 | -0.056 | 1 | 0.591 |
CAMK1A |
0.767 | -0.062 | -3 | 0.636 |
IRAK1 |
0.767 | -0.366 | -1 | 0.741 |
HPK1 |
0.767 | -0.175 | 1 | 0.732 |
SLK |
0.767 | -0.151 | -2 | 0.632 |
NEK4 |
0.766 | -0.288 | 1 | 0.733 |
KHS2 |
0.766 | -0.093 | 1 | 0.737 |
PKCI |
0.766 | -0.183 | 2 | 0.672 |
KHS1 |
0.766 | -0.128 | 1 | 0.719 |
MAP3K15 |
0.766 | -0.272 | 1 | 0.690 |
SBK |
0.766 | -0.016 | -3 | 0.551 |
CDK4 |
0.765 | -0.059 | 1 | 0.577 |
MRCKB |
0.765 | -0.078 | -3 | 0.712 |
MOK |
0.765 | -0.024 | 1 | 0.706 |
NEK1 |
0.764 | -0.240 | 1 | 0.743 |
AKT3 |
0.764 | -0.060 | -3 | 0.608 |
LOK |
0.763 | -0.200 | -2 | 0.655 |
CHK2 |
0.763 | -0.086 | -3 | 0.610 |
MAP2K4_TYR |
0.763 | 0.068 | -1 | 0.872 |
DMPK1 |
0.763 | -0.023 | -3 | 0.742 |
PAK5 |
0.763 | -0.164 | -2 | 0.495 |
MEK2 |
0.762 | -0.271 | 2 | 0.741 |
BMPR2_TYR |
0.762 | 0.077 | -1 | 0.892 |
MEKK6 |
0.761 | -0.324 | 1 | 0.721 |
TESK1_TYR |
0.761 | -0.047 | 3 | 0.778 |
PAK4 |
0.760 | -0.153 | -2 | 0.507 |
STK33 |
0.760 | -0.219 | 2 | 0.545 |
BUB1 |
0.760 | -0.071 | -5 | 0.748 |
PKN1 |
0.760 | -0.139 | -3 | 0.688 |
CK1A |
0.758 | -0.022 | -3 | 0.462 |
TXK |
0.758 | 0.176 | 1 | 0.843 |
BIKE |
0.758 | -0.007 | 1 | 0.692 |
PBK |
0.758 | -0.109 | 1 | 0.733 |
YSK1 |
0.757 | -0.228 | 2 | 0.732 |
MAP2K7_TYR |
0.757 | -0.139 | 2 | 0.795 |
YANK3 |
0.757 | -0.081 | 2 | 0.361 |
PINK1_TYR |
0.754 | -0.142 | 1 | 0.801 |
RIPK2 |
0.753 | -0.356 | 1 | 0.674 |
EPHA6 |
0.752 | 0.047 | -1 | 0.898 |
PKMYT1_TYR |
0.752 | -0.168 | 3 | 0.739 |
ROCK1 |
0.752 | -0.084 | -3 | 0.731 |
CRIK |
0.751 | -0.051 | -3 | 0.684 |
HASPIN |
0.749 | -0.111 | -1 | 0.642 |
YES1 |
0.749 | 0.006 | -1 | 0.879 |
MYO3A |
0.748 | -0.168 | 1 | 0.733 |
EPHA4 |
0.747 | 0.049 | 2 | 0.716 |
SRMS |
0.747 | 0.045 | 1 | 0.834 |
BLK |
0.747 | 0.096 | -1 | 0.884 |
LIMK2_TYR |
0.747 | -0.143 | -3 | 0.856 |
FER |
0.747 | -0.017 | 1 | 0.850 |
ASK1 |
0.746 | -0.251 | 1 | 0.679 |
EPHB4 |
0.746 | -0.043 | -1 | 0.875 |
MYO3B |
0.746 | -0.187 | 2 | 0.749 |
INSRR |
0.745 | -0.017 | 3 | 0.607 |
FGR |
0.745 | -0.059 | 1 | 0.795 |
LCK |
0.744 | 0.046 | -1 | 0.878 |
STLK3 |
0.744 | -0.190 | 1 | 0.679 |
FYN |
0.743 | 0.089 | -1 | 0.868 |
RET |
0.743 | -0.191 | 1 | 0.736 |
CK1G3 |
0.743 | -0.003 | -3 | 0.420 |
PKG1 |
0.742 | -0.151 | -2 | 0.423 |
HCK |
0.742 | -0.025 | -1 | 0.870 |
NEK3 |
0.742 | -0.318 | 1 | 0.682 |
AAK1 |
0.742 | 0.029 | 1 | 0.588 |
LIMK1_TYR |
0.741 | -0.262 | 2 | 0.780 |
ABL2 |
0.741 | -0.063 | -1 | 0.834 |
EPHB2 |
0.741 | 0.021 | -1 | 0.864 |
TAO1 |
0.740 | -0.218 | 1 | 0.655 |
TYK2 |
0.740 | -0.242 | 1 | 0.734 |
TYRO3 |
0.740 | -0.185 | 3 | 0.653 |
ITK |
0.739 | -0.042 | -1 | 0.831 |
ROS1 |
0.739 | -0.194 | 3 | 0.622 |
EPHB1 |
0.738 | -0.046 | 1 | 0.812 |
CSF1R |
0.738 | -0.157 | 3 | 0.637 |
JAK3 |
0.738 | -0.122 | 1 | 0.722 |
EPHB3 |
0.737 | -0.035 | -1 | 0.864 |
MST1R |
0.737 | -0.243 | 3 | 0.661 |
JAK2 |
0.735 | -0.246 | 1 | 0.721 |
ABL1 |
0.735 | -0.103 | -1 | 0.826 |
KIT |
0.734 | -0.122 | 3 | 0.643 |
BMX |
0.734 | -0.033 | -1 | 0.759 |
FGFR2 |
0.733 | -0.131 | 3 | 0.660 |
TEC |
0.733 | -0.022 | -1 | 0.765 |
SYK |
0.732 | 0.091 | -1 | 0.834 |
DDR1 |
0.732 | -0.261 | 4 | 0.823 |
FLT1 |
0.732 | -0.041 | -1 | 0.875 |
PTK2 |
0.732 | 0.077 | -1 | 0.852 |
PTK6 |
0.732 | -0.112 | -1 | 0.751 |
EPHA5 |
0.731 | 0.023 | 2 | 0.707 |
EPHA7 |
0.730 | -0.038 | 2 | 0.707 |
TNK2 |
0.730 | -0.160 | 3 | 0.606 |
MERTK |
0.730 | -0.102 | 3 | 0.627 |
MET |
0.730 | -0.110 | 3 | 0.623 |
FLT3 |
0.729 | -0.178 | 3 | 0.641 |
LYN |
0.729 | -0.040 | 3 | 0.584 |
EPHA3 |
0.729 | -0.086 | 2 | 0.694 |
KDR |
0.729 | -0.157 | 3 | 0.601 |
PDGFRB |
0.728 | -0.238 | 3 | 0.651 |
EGFR |
0.728 | -0.014 | 1 | 0.604 |
TEK |
0.727 | -0.185 | 3 | 0.590 |
NEK10_TYR |
0.727 | -0.174 | 1 | 0.617 |
CK1G2 |
0.727 | -0.008 | -3 | 0.509 |
SRC |
0.726 | -0.027 | -1 | 0.860 |
EPHA8 |
0.726 | -0.016 | -1 | 0.863 |
ERBB2 |
0.726 | -0.130 | 1 | 0.700 |
FGFR3 |
0.726 | -0.114 | 3 | 0.631 |
FRK |
0.726 | -0.072 | -1 | 0.874 |
FGFR1 |
0.725 | -0.198 | 3 | 0.623 |
NTRK1 |
0.725 | -0.172 | -1 | 0.841 |
BTK |
0.724 | -0.193 | -1 | 0.785 |
YANK2 |
0.723 | -0.101 | 2 | 0.383 |
AXL |
0.723 | -0.206 | 3 | 0.624 |
PTK2B |
0.722 | -0.060 | -1 | 0.800 |
WEE1_TYR |
0.722 | -0.152 | -1 | 0.744 |
LTK |
0.722 | -0.175 | 3 | 0.594 |
INSR |
0.721 | -0.164 | 3 | 0.591 |
TNNI3K_TYR |
0.721 | -0.196 | 1 | 0.732 |
ALK |
0.720 | -0.213 | 3 | 0.565 |
JAK1 |
0.720 | -0.222 | 1 | 0.669 |
FLT4 |
0.719 | -0.192 | 3 | 0.618 |
FGFR4 |
0.719 | -0.065 | -1 | 0.803 |
NTRK3 |
0.718 | -0.141 | -1 | 0.796 |
PDGFRA |
0.718 | -0.323 | 3 | 0.650 |
MATK |
0.718 | -0.131 | -1 | 0.761 |
TNK1 |
0.717 | -0.273 | 3 | 0.637 |
EPHA1 |
0.717 | -0.169 | 3 | 0.590 |
EPHA2 |
0.716 | -0.019 | -1 | 0.829 |
NTRK2 |
0.716 | -0.223 | 3 | 0.604 |
ERBB4 |
0.715 | -0.021 | 1 | 0.649 |
CSK |
0.714 | -0.152 | 2 | 0.711 |
IGF1R |
0.711 | -0.112 | 3 | 0.539 |
DDR2 |
0.710 | -0.176 | 3 | 0.593 |
ZAP70 |
0.697 | -0.045 | -1 | 0.745 |
MUSK |
0.696 | -0.206 | 1 | 0.593 |
FES |
0.693 | -0.149 | -1 | 0.736 |