Motif 621 (n=122)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H0YC42 | None | S156 | ochoa | Tumor protein D52 | None |
| O00192 | ARVCF | S871 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14686 | KMT2D | S2281 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43175 | PHGDH | S287 | ochoa | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O43795 | MYO1B | S60 | ochoa | Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) | Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}. |
| O60447 | EVI5 | S776 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
| O75363 | BCAS1 | S296 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75369 | FLNB | S2113 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75369 | FLNB | S2227 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O76070 | SNCG | S73 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| P00747 | PLG | S45 | ochoa | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093, ECO:0000269|PubMed:6447255}.; FUNCTION: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.; FUNCTION: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403). {ECO:0000269|PubMed:21949403}.; FUNCTION: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. {ECO:0000269|PubMed:22433849}.; FUNCTION: (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374). {ECO:0000269|PubMed:31726374}. |
| P01241 | GH1 | S134 | psp | Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
| P07900 | HSP90AA1 | S641 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08567 | PLEK | S132 | ochoa | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P0DJD0 | RGPD1 | S1577 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1585 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | S267 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12882 | MYH1 | S1162 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1158 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1160 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P17677 | GAP43 | S96 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P20810 | CAST | S526 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S1899 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2158 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21796 | VDAC1 | S193 | psp | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P25205 | MCM3 | S728 | ochoa|psp | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P28290 | ITPRID2 | S466 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P31431 | SDC4 | S97 | ochoa | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}. |
| P36382 | GJA5 | S122 | ochoa | Gap junction alpha-5 protein (Connexin-40) (Cx40) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P49792 | RANBP2 | S2568 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49902 | NT5C2 | S417 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50402 | EMD | S29 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P55008 | AIF1 | S38 | ochoa | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}. |
| P56182 | RRP1 | S272 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P60981 | DSTN | S88 | ochoa | Destrin (Actin-depolymerizing factor) (ADF) | Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}. |
| P78347 | GTF2I | S710 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P82912 | MRPS11 | S71 | ochoa | Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) | None |
| Q01664 | TFAP4 | S139 | ochoa|psp | Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) | Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. |
| Q02790 | FKBP4 | S258 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q05209 | PTPN12 | S704 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05513 | PRKCZ | S190 | ochoa | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q08211 | DHX9 | S625 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q09666 | AHNAK | S539 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S468 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | S127 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12912 | IRAG2 | S427 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13427 | PPIG | S716 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13459 | MYO9B | S1045 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13555 | CAMK2G | S26 | psp | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q14207 | NPAT | S659 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14315 | FLNC | S1893 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S2348 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S2448 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14896 | MYBPC3 | S304 | psp | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14D04 | VEPH1 | S380 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15029 | EFTUD2 | S950 | ochoa | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000305|PubMed:33509932}. |
| Q15334 | LLGL1 | S961 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15652 | JMJD1C | S319 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q2TAL8 | QRICH1 | S345 | ochoa | Transcriptional regulator QRICH1 (Glutamine-rich protein 1) | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. |
| Q5R3F8 | ELFN2 | S451 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| Q5SW79 | CEP170 | S1059 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T200 | ZC3H13 | S1232 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5W0B1 | OBI1 | S574 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6GYQ0 | RALGAPA1 | S503 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6PL18 | ATAD2 | S1277 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q7Z3J3 | RGPD4 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6E9 | RBBP6 | S1226 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6Z7 | HUWE1 | S3759 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q8N1W1 | ARHGEF28 | S590 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N5C8 | TAB3 | S357 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NEZ4 | KMT2C | S2828 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NEZ5 | FBXO22 | S162 | psp | F-box only protein 22 (F-box protein FBX22p44) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933). {ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:22972877, ECO:0000269|PubMed:26868148, ECO:0000269|PubMed:37979583, ECO:0000269|PubMed:39223933, ECO:0000269|PubMed:39504958}. |
| Q8NFQ8 | TOR1AIP2 | S188 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NI08 | NCOA7 | S441 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TF72 | SHROOM3 | S1725 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUM0 | NUP133 | S501 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WXX7 | AUTS2 | S958 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92628 | KIAA0232 | S1122 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q96CN5 | LRRC45 | S337 | ochoa | Leucine-rich repeat-containing protein 45 | Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. {ECO:0000269|PubMed:24035387}. |
| Q96EB6 | SIRT1 | S571 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96JB1 | DNAH8 | S3112 | ochoa | Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) | Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269|PubMed:32619401}. |
| Q96S38 | RPS6KC1 | S427 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S38 | RPS6KC1 | S528 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99666 | RGPD5 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BTC0 | DIDO1 | S352 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BXJ1 | C1QTNF1 | S229 | ochoa | Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) | None |
| Q9BXW9 | FANCD2 | S1257 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9H0E9 | BRD8 | S383 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H706 | GAREM1 | S449 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H814 | PHAX | S368 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9NS23 | RASSF1 | S135 | psp | Ras association domain-containing protein 1 | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}. |
| Q9NZM3 | ITSN2 | S1046 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P2D6 | FAM135A | S621 | ochoa | Protein FAM135A | None |
| Q9P2F8 | SIPA1L2 | S1304 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UEW8 | STK39 | S401 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UHD1 | CHORDC1 | S136 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| Q9UHK0 | NUFIP1 | S312 | ochoa | FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) | Binds RNA. {ECO:0000269|PubMed:10556305}. |
| Q9UKX2 | MYH2 | S1164 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9Y4P1 | ATG4B | S316 | psp | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q9Y623 | MYH4 | S1162 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q15398 | DLGAP5 | S446 | Sugiyama | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| P30566 | ADSL | S407 | Sugiyama | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| O43399 | TPD52L2 | S104 | Sugiyama | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| P43490 | NAMPT | S35 | Sugiyama | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P52926 | HMGA2 | S59 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| Q8WZ42 | TTN | S20768 | Sugiyama | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| P51812 | RPS6KA3 | S434 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S427 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9UK32 | RPS6KA6 | S438 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| O60664 | PLIN3 | S76 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| Q9H5V8 | CDCP1 | S288 | Sugiyama | CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318) | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Q13554 | CAMK2B | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13557 | CAMK2D | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q9UQM7 | CAMK2A | S25 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q15418 | RPS6KA1 | S430 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| P15735 | PHKG2 | S36 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| Q16816 | PHKG1 | S32 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q16816 | PHKG1 | S58 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q8IY84 | NIM1K | S86 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q9UHD2 | TBK1 | S243 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.995072e-09 | 8.700 |
| R-HSA-3371556 | Cellular response to heat stress | 2.605931e-07 | 6.584 |
| R-HSA-3371571 | HSF1-dependent transactivation | 8.146013e-07 | 6.089 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.805067e-06 | 5.744 |
| R-HSA-444257 | RSK activation | 2.682523e-06 | 5.571 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 5.165452e-06 | 5.287 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.907449e-06 | 5.229 |
| R-HSA-199920 | CREB phosphorylation | 6.624532e-05 | 4.179 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 8.778035e-05 | 4.057 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 8.778035e-05 | 4.057 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 8.778035e-05 | 4.057 |
| R-HSA-9620244 | Long-term potentiation | 1.486474e-04 | 3.828 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.109645e-04 | 3.676 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.901949e-04 | 3.537 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.536205e-04 | 3.451 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.536205e-04 | 3.451 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.971736e-04 | 3.303 |
| R-HSA-111933 | Calmodulin induced events | 5.092759e-04 | 3.293 |
| R-HSA-111997 | CaM pathway | 5.092759e-04 | 3.293 |
| R-HSA-5673000 | RAF activation | 4.263961e-04 | 3.370 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.177661e-04 | 3.209 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.177661e-04 | 3.209 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 8.483941e-04 | 3.071 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.148615e-04 | 3.089 |
| R-HSA-111996 | Ca-dependent events | 8.899915e-04 | 3.051 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.261983e-04 | 3.083 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.379342e-04 | 3.077 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.261983e-04 | 3.083 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.014962e-03 | 2.994 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.146181e-03 | 2.941 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.102125e-03 | 2.958 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.180079e-03 | 2.928 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.180079e-03 | 2.928 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.180079e-03 | 2.928 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.180079e-03 | 2.928 |
| R-HSA-198753 | ERK/MAPK targets | 1.439622e-03 | 2.842 |
| R-HSA-437239 | Recycling pathway of L1 | 1.261816e-03 | 2.899 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.644711e-03 | 2.784 |
| R-HSA-5578775 | Ion homeostasis | 2.183634e-03 | 2.661 |
| R-HSA-1632852 | Macroautophagy | 2.284719e-03 | 2.641 |
| R-HSA-9612973 | Autophagy | 3.658730e-03 | 2.437 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.911379e-03 | 2.536 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 3.301862e-03 | 2.481 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.489178e-03 | 2.457 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.580239e-03 | 2.446 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.596190e-03 | 2.444 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.324865e-03 | 2.478 |
| R-HSA-112043 | PLC beta mediated events | 2.857227e-03 | 2.544 |
| R-HSA-450294 | MAP kinase activation | 2.857227e-03 | 2.544 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.707376e-03 | 2.431 |
| R-HSA-397014 | Muscle contraction | 3.598329e-03 | 2.444 |
| R-HSA-112040 | G-protein mediated events | 3.838157e-03 | 2.416 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.323072e-03 | 2.478 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 3.973463e-03 | 2.401 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 3.973463e-03 | 2.401 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.248459e-03 | 2.372 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.404844e-03 | 2.356 |
| R-HSA-448424 | Interleukin-17 signaling | 4.404844e-03 | 2.356 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.689677e-03 | 2.329 |
| R-HSA-390522 | Striated Muscle Contraction | 4.814890e-03 | 2.317 |
| R-HSA-373760 | L1CAM interactions | 5.001347e-03 | 2.301 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 5.489401e-03 | 2.260 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.506759e-03 | 2.259 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 7.229055e-03 | 2.141 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 7.229055e-03 | 2.141 |
| R-HSA-3371568 | Attenuation phase | 7.487113e-03 | 2.126 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 8.180347e-03 | 2.087 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.090104e-03 | 2.092 |
| R-HSA-913531 | Interferon Signaling | 7.274751e-03 | 2.138 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.642087e-03 | 2.063 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.877676e-03 | 2.052 |
| R-HSA-9663891 | Selective autophagy | 9.333890e-03 | 2.030 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.024111e-02 | 1.990 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.024111e-02 | 1.990 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.034424e-02 | 1.985 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.134871e-02 | 1.945 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.134871e-02 | 1.945 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.134871e-02 | 1.945 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.159813e-02 | 1.936 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.371379e-02 | 1.863 |
| R-HSA-2262752 | Cellular responses to stress | 1.377407e-02 | 1.861 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.379159e-02 | 1.860 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.379159e-02 | 1.860 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.379159e-02 | 1.860 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.662830e-02 | 1.779 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.627273e-02 | 1.789 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.777135e-02 | 1.750 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.553187e-02 | 1.809 |
| R-HSA-111885 | Opioid Signalling | 1.645156e-02 | 1.784 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.539353e-02 | 1.813 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.828480e-02 | 1.738 |
| R-HSA-191859 | snRNP Assembly | 1.923089e-02 | 1.716 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.923089e-02 | 1.716 |
| R-HSA-186797 | Signaling by PDGF | 2.154116e-02 | 1.667 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.194438e-02 | 1.659 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.483924e-02 | 1.605 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.504359e-02 | 1.601 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.627319e-02 | 1.580 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.627319e-02 | 1.580 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.298212e-02 | 1.482 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.298212e-02 | 1.482 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.298212e-02 | 1.482 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.298212e-02 | 1.482 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.298212e-02 | 1.482 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.298212e-02 | 1.482 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.298212e-02 | 1.482 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.298212e-02 | 1.482 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.298212e-02 | 1.482 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.298212e-02 | 1.482 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.298212e-02 | 1.482 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.716408e-02 | 1.430 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.350803e-02 | 1.475 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.716408e-02 | 1.430 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.716408e-02 | 1.430 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.830971e-02 | 1.548 |
| R-HSA-114608 | Platelet degranulation | 3.226276e-02 | 1.491 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.631089e-02 | 1.440 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.322945e-02 | 1.478 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.818828e-02 | 1.550 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.818828e-02 | 1.550 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.716408e-02 | 1.430 |
| R-HSA-5576891 | Cardiac conduction | 3.590892e-02 | 1.445 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.029117e-02 | 1.519 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.743155e-02 | 1.427 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.904703e-02 | 1.408 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.904703e-02 | 1.408 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.064012e-02 | 1.391 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.105750e-02 | 1.387 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.105750e-02 | 1.387 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 4.105750e-02 | 1.387 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.291912e-02 | 1.367 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.291912e-02 | 1.367 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.490684e-02 | 1.348 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.490684e-02 | 1.348 |
| R-HSA-5205647 | Mitophagy | 4.692808e-02 | 1.329 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.692808e-02 | 1.329 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.692808e-02 | 1.329 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 4.692808e-02 | 1.329 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.898215e-02 | 1.310 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 4.906594e-02 | 1.309 |
| R-HSA-422475 | Axon guidance | 4.950841e-02 | 1.305 |
| R-HSA-3371511 | HSF1 activation | 5.106837e-02 | 1.292 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.318607e-02 | 1.274 |
| R-HSA-112316 | Neuronal System | 5.443001e-02 | 1.264 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.533458e-02 | 1.257 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.563728e-02 | 1.255 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 5.700800e-02 | 1.244 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.751325e-02 | 1.240 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.751325e-02 | 1.240 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.758139e-02 | 1.240 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 6.488421e-02 | 1.188 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.044126e-02 | 1.095 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.972145e-02 | 1.224 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 7.355541e-02 | 1.133 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.856703e-02 | 1.232 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.972145e-02 | 1.224 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.972145e-02 | 1.224 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 6.195852e-02 | 1.208 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 8.044126e-02 | 1.095 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 7.595287e-02 | 1.119 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.862105e-02 | 1.232 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.195852e-02 | 1.208 |
| R-HSA-168255 | Influenza Infection | 8.608372e-02 | 1.065 |
| R-HSA-168256 | Immune System | 8.627193e-02 | 1.064 |
| R-HSA-8982491 | Glycogen metabolism | 5.972145e-02 | 1.224 |
| R-HSA-211000 | Gene Silencing by RNA | 7.918358e-02 | 1.101 |
| R-HSA-877300 | Interferon gamma signaling | 6.259965e-02 | 1.203 |
| R-HSA-2559583 | Cellular Senescence | 8.729627e-02 | 1.059 |
| R-HSA-9675108 | Nervous system development | 6.797830e-02 | 1.168 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 9.083569e-02 | 1.042 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 9.083569e-02 | 1.042 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.126554e-02 | 1.040 |
| R-HSA-449147 | Signaling by Interleukins | 9.430135e-02 | 1.025 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 9.574138e-02 | 1.019 |
| R-HSA-9613354 | Lipophagy | 9.574138e-02 | 1.019 |
| R-HSA-176974 | Unwinding of DNA | 9.574138e-02 | 1.019 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 9.574138e-02 | 1.019 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 9.574138e-02 | 1.019 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.574138e-02 | 1.019 |
| R-HSA-9012852 | Signaling by NOTCH3 | 9.857259e-02 | 1.006 |
| R-HSA-983712 | Ion channel transport | 9.857918e-02 | 1.006 |
| R-HSA-75893 | TNF signaling | 1.011918e-01 | 0.995 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 1.255876e-01 | 0.901 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 1.255876e-01 | 0.901 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.255876e-01 | 0.901 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.473287e-01 | 0.832 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.473287e-01 | 0.832 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 1.615238e-01 | 0.792 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 1.615238e-01 | 0.792 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.685331e-01 | 0.773 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.685331e-01 | 0.773 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 1.685331e-01 | 0.773 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.823777e-01 | 0.739 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.959935e-01 | 0.708 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.959935e-01 | 0.708 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.866956e-01 | 0.729 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.866956e-01 | 0.729 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.747146e-01 | 0.758 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.339884e-01 | 0.873 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.078296e-01 | 0.967 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.140871e-01 | 0.943 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.140871e-01 | 0.943 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.140871e-01 | 0.943 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.482817e-01 | 0.829 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.107888e-01 | 0.956 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.892140e-01 | 0.723 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.473287e-01 | 0.832 |
| R-HSA-192905 | vRNP Assembly | 1.107888e-01 | 0.956 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.328951e-01 | 0.876 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.615238e-01 | 0.792 |
| R-HSA-9694614 | Attachment and Entry | 2.027168e-01 | 0.693 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.615238e-01 | 0.792 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.687729e-01 | 0.773 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.623166e-01 | 0.790 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.339884e-01 | 0.873 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.107888e-01 | 0.956 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.473287e-01 | 0.832 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.959935e-01 | 0.708 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.959935e-01 | 0.708 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.145672e-01 | 0.941 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.823777e-01 | 0.739 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.687729e-01 | 0.773 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.754843e-01 | 0.756 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.032964e-01 | 0.986 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.255876e-01 | 0.901 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.118565e-01 | 0.951 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.107888e-01 | 0.956 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.027168e-01 | 0.693 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.453980e-01 | 0.837 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.615238e-01 | 0.792 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.754843e-01 | 0.756 |
| R-HSA-9755088 | Ribavirin ADME | 2.027168e-01 | 0.693 |
| R-HSA-2161541 | Abacavir metabolism | 1.959935e-01 | 0.708 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.027168e-01 | 0.693 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.172947e-01 | 0.931 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.648341e-01 | 0.783 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 1.959935e-01 | 0.708 |
| R-HSA-977347 | Serine metabolism | 2.027168e-01 | 0.693 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.478079e-01 | 0.830 |
| R-HSA-68875 | Mitotic Prophase | 1.035849e-01 | 0.985 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.544558e-01 | 0.811 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 1.286864e-01 | 0.890 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.823777e-01 | 0.739 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.425265e-01 | 0.846 |
| R-HSA-74160 | Gene expression (Transcription) | 1.066746e-01 | 0.972 |
| R-HSA-8983711 | OAS antiviral response | 1.255876e-01 | 0.901 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.615238e-01 | 0.792 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.677867e-01 | 0.775 |
| R-HSA-9909396 | Circadian clock | 1.286864e-01 | 0.890 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.642921e-01 | 0.784 |
| R-HSA-9679506 | SARS-CoV Infections | 1.122622e-01 | 0.950 |
| R-HSA-162582 | Signal Transduction | 1.396170e-01 | 0.855 |
| R-HSA-73887 | Death Receptor Signaling | 1.759913e-01 | 0.755 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.023061e-01 | 0.990 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.194846e-01 | 0.923 |
| R-HSA-166520 | Signaling by NTRKs | 1.637281e-01 | 0.786 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.057000e-01 | 0.687 |
| R-HSA-3000170 | Syndecan interactions | 2.159963e-01 | 0.666 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.201623e-01 | 0.657 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.207056e-01 | 0.656 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.225535e-01 | 0.653 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.225535e-01 | 0.653 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.225535e-01 | 0.653 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.290563e-01 | 0.640 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.290563e-01 | 0.640 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.293837e-01 | 0.639 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.355051e-01 | 0.628 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.355051e-01 | 0.628 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.355051e-01 | 0.628 |
| R-HSA-2161522 | Abacavir ADME | 2.355051e-01 | 0.628 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.355051e-01 | 0.628 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.386314e-01 | 0.622 |
| R-HSA-70171 | Glycolysis | 2.386314e-01 | 0.622 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.417185e-01 | 0.617 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.419003e-01 | 0.616 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.419003e-01 | 0.616 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.419003e-01 | 0.616 |
| R-HSA-212436 | Generic Transcription Pathway | 2.444608e-01 | 0.612 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.482831e-01 | 0.605 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.540836e-01 | 0.595 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.540836e-01 | 0.595 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.545319e-01 | 0.594 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.545319e-01 | 0.594 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 2.545319e-01 | 0.594 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.602727e-01 | 0.585 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.607691e-01 | 0.584 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.607691e-01 | 0.584 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.607691e-01 | 0.584 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.610615e-01 | 0.583 |
| R-HSA-68877 | Mitotic Prometaphase | 2.629107e-01 | 0.580 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.651634e-01 | 0.576 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.669545e-01 | 0.574 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.669545e-01 | 0.574 |
| R-HSA-182971 | EGFR downregulation | 2.669545e-01 | 0.574 |
| R-HSA-1640170 | Cell Cycle | 2.685791e-01 | 0.571 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.690080e-01 | 0.570 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.695594e-01 | 0.569 |
| R-HSA-2024096 | HS-GAG degradation | 2.730886e-01 | 0.564 |
| R-HSA-69190 | DNA strand elongation | 2.730886e-01 | 0.564 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.739671e-01 | 0.562 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.788445e-01 | 0.555 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.791717e-01 | 0.554 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.791717e-01 | 0.554 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.791717e-01 | 0.554 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.791717e-01 | 0.554 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.881224e-01 | 0.540 |
| R-HSA-72172 | mRNA Splicing | 2.900839e-01 | 0.537 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 2.911867e-01 | 0.536 |
| R-HSA-203615 | eNOS activation | 2.911867e-01 | 0.536 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.911867e-01 | 0.536 |
| R-HSA-190861 | Gap junction assembly | 2.911867e-01 | 0.536 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.943010e-01 | 0.531 |
| R-HSA-70326 | Glucose metabolism | 3.004726e-01 | 0.522 |
| R-HSA-2022928 | HS-GAG biosynthesis | 3.030029e-01 | 0.519 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.030029e-01 | 0.519 |
| R-HSA-163560 | Triglyceride catabolism | 3.030029e-01 | 0.519 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.088375e-01 | 0.510 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.088375e-01 | 0.510 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.088375e-01 | 0.510 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.106054e-01 | 0.508 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.127886e-01 | 0.505 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.146235e-01 | 0.502 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.146235e-01 | 0.502 |
| R-HSA-68882 | Mitotic Anaphase | 3.174599e-01 | 0.498 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.197456e-01 | 0.495 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.203615e-01 | 0.494 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.203615e-01 | 0.494 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.219965e-01 | 0.492 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.260519e-01 | 0.487 |
| R-HSA-5260271 | Diseases of Immune System | 3.260519e-01 | 0.487 |
| R-HSA-9646399 | Aggrephagy | 3.260519e-01 | 0.487 |
| R-HSA-194138 | Signaling by VEGF | 3.281187e-01 | 0.484 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.316949e-01 | 0.479 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.316949e-01 | 0.479 |
| R-HSA-69481 | G2/M Checkpoints | 3.342264e-01 | 0.476 |
| R-HSA-1474244 | Extracellular matrix organization | 3.397632e-01 | 0.469 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.403192e-01 | 0.468 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.428406e-01 | 0.465 |
| R-HSA-168249 | Innate Immune System | 3.430288e-01 | 0.465 |
| R-HSA-388396 | GPCR downstream signalling | 3.501901e-01 | 0.456 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.538018e-01 | 0.451 |
| R-HSA-190828 | Gap junction trafficking | 3.538018e-01 | 0.451 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.538018e-01 | 0.451 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.585787e-01 | 0.445 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.592141e-01 | 0.445 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 3.592141e-01 | 0.445 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.606525e-01 | 0.443 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.645815e-01 | 0.438 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.645815e-01 | 0.438 |
| R-HSA-8939211 | ESR-mediated signaling | 3.654109e-01 | 0.437 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.675074e-01 | 0.435 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.692764e-01 | 0.433 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.699042e-01 | 0.432 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.699042e-01 | 0.432 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.699239e-01 | 0.432 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.701486e-01 | 0.432 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.705030e-01 | 0.431 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.751827e-01 | 0.426 |
| R-HSA-9664407 | Parasite infection | 3.794563e-01 | 0.421 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.794563e-01 | 0.421 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.794563e-01 | 0.421 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.804173e-01 | 0.420 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.883569e-01 | 0.411 |
| R-HSA-4839726 | Chromatin organization | 3.926094e-01 | 0.406 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.958612e-01 | 0.402 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.958612e-01 | 0.402 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.958612e-01 | 0.402 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.009238e-01 | 0.397 |
| R-HSA-1221632 | Meiotic synapsis | 4.009238e-01 | 0.397 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.009238e-01 | 0.397 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.118121e-01 | 0.385 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.158603e-01 | 0.381 |
| R-HSA-177929 | Signaling by EGFR | 4.158603e-01 | 0.381 |
| R-HSA-9609507 | Protein localization | 4.204956e-01 | 0.376 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.256119e-01 | 0.371 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.256119e-01 | 0.371 |
| R-HSA-416476 | G alpha (q) signalling events | 4.261851e-01 | 0.370 |
| R-HSA-8953854 | Metabolism of RNA | 4.282261e-01 | 0.368 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 4.304270e-01 | 0.366 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.304270e-01 | 0.366 |
| R-HSA-8979227 | Triglyceride metabolism | 4.304270e-01 | 0.366 |
| R-HSA-9610379 | HCMV Late Events | 4.319723e-01 | 0.365 |
| R-HSA-162587 | HIV Life Cycle | 4.319723e-01 | 0.365 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.352020e-01 | 0.361 |
| R-HSA-68886 | M Phase | 4.379977e-01 | 0.359 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.398593e-01 | 0.357 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.446332e-01 | 0.352 |
| R-HSA-9707616 | Heme signaling | 4.446332e-01 | 0.352 |
| R-HSA-1268020 | Mitochondrial protein import | 4.446332e-01 | 0.352 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.446332e-01 | 0.352 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.492899e-01 | 0.347 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.492899e-01 | 0.347 |
| R-HSA-373755 | Semaphorin interactions | 4.492899e-01 | 0.347 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.517643e-01 | 0.345 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.539079e-01 | 0.343 |
| R-HSA-372790 | Signaling by GPCR | 4.563525e-01 | 0.341 |
| R-HSA-446728 | Cell junction organization | 4.569416e-01 | 0.340 |
| R-HSA-5619102 | SLC transporter disorders | 4.601278e-01 | 0.337 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.630290e-01 | 0.334 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.630290e-01 | 0.334 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.675326e-01 | 0.330 |
| R-HSA-196807 | Nicotinate metabolism | 4.675326e-01 | 0.330 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.711643e-01 | 0.327 |
| R-HSA-72306 | tRNA processing | 4.711643e-01 | 0.327 |
| R-HSA-5218859 | Regulated Necrosis | 4.719988e-01 | 0.326 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.793535e-01 | 0.319 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.808198e-01 | 0.318 |
| R-HSA-418594 | G alpha (i) signalling events | 4.839493e-01 | 0.315 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.847703e-01 | 0.314 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.851753e-01 | 0.314 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.851753e-01 | 0.314 |
| R-HSA-975634 | Retinoid metabolism and transport | 4.851753e-01 | 0.314 |
| R-HSA-8978934 | Metabolism of cofactors | 4.851753e-01 | 0.314 |
| R-HSA-74259 | Purine catabolism | 4.894946e-01 | 0.310 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.937778e-01 | 0.306 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.937778e-01 | 0.306 |
| R-HSA-4086398 | Ca2+ pathway | 4.937778e-01 | 0.306 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.937778e-01 | 0.306 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.980254e-01 | 0.303 |
| R-HSA-380287 | Centrosome maturation | 5.022377e-01 | 0.299 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.022377e-01 | 0.299 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.064148e-01 | 0.295 |
| R-HSA-69275 | G2/M Transition | 5.139349e-01 | 0.289 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.146649e-01 | 0.288 |
| R-HSA-216083 | Integrin cell surface interactions | 5.146649e-01 | 0.288 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.146649e-01 | 0.288 |
| R-HSA-109582 | Hemostasis | 5.151785e-01 | 0.288 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 5.187386e-01 | 0.285 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.191210e-01 | 0.285 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.191210e-01 | 0.285 |
| R-HSA-9833482 | PKR-mediated signaling | 5.227782e-01 | 0.282 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.267842e-01 | 0.278 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 5.267842e-01 | 0.278 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.293832e-01 | 0.276 |
| R-HSA-1500931 | Cell-Cell communication | 5.366011e-01 | 0.270 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.386030e-01 | 0.269 |
| R-HSA-9609690 | HCMV Early Events | 5.394975e-01 | 0.268 |
| R-HSA-1500620 | Meiosis | 5.424772e-01 | 0.266 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.501288e-01 | 0.260 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.501288e-01 | 0.260 |
| R-HSA-70268 | Pyruvate metabolism | 5.539069e-01 | 0.257 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.568374e-01 | 0.254 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.576534e-01 | 0.254 |
| R-HSA-156902 | Peptide chain elongation | 5.576534e-01 | 0.254 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.576534e-01 | 0.254 |
| R-HSA-5357801 | Programmed Cell Death | 5.641272e-01 | 0.249 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.650531e-01 | 0.248 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.687067e-01 | 0.245 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.723299e-01 | 0.242 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.723299e-01 | 0.242 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.759229e-01 | 0.240 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.759229e-01 | 0.240 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.794859e-01 | 0.237 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.865229e-01 | 0.232 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.899975e-01 | 0.229 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.899975e-01 | 0.229 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.899975e-01 | 0.229 |
| R-HSA-5389840 | Mitochondrial translation elongation | 5.934431e-01 | 0.227 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.934431e-01 | 0.227 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.968599e-01 | 0.224 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.002483e-01 | 0.222 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.002483e-01 | 0.222 |
| R-HSA-3214847 | HATs acetylate histones | 6.036084e-01 | 0.219 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.036084e-01 | 0.219 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.036084e-01 | 0.219 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.102446e-01 | 0.214 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.102446e-01 | 0.214 |
| R-HSA-162906 | HIV Infection | 6.149614e-01 | 0.211 |
| R-HSA-192823 | Viral mRNA Translation | 6.167706e-01 | 0.210 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.167706e-01 | 0.210 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.199928e-01 | 0.208 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.199928e-01 | 0.208 |
| R-HSA-9833110 | RSV-host interactions | 6.231881e-01 | 0.205 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.253955e-01 | 0.204 |
| R-HSA-72312 | rRNA processing | 6.258685e-01 | 0.204 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.271546e-01 | 0.203 |
| R-HSA-9824446 | Viral Infection Pathways | 6.306253e-01 | 0.200 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.326149e-01 | 0.199 |
| R-HSA-69239 | Synthesis of DNA | 6.326149e-01 | 0.199 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.326149e-01 | 0.199 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.326149e-01 | 0.199 |
| R-HSA-15869 | Metabolism of nucleotides | 6.344224e-01 | 0.198 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.357049e-01 | 0.197 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.357049e-01 | 0.197 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.387690e-01 | 0.195 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.387690e-01 | 0.195 |
| R-HSA-157118 | Signaling by NOTCH | 6.428242e-01 | 0.192 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.478088e-01 | 0.189 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.478088e-01 | 0.189 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.537102e-01 | 0.185 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.537102e-01 | 0.185 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.571633e-01 | 0.182 |
| R-HSA-9609646 | HCMV Infection | 6.631676e-01 | 0.178 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.652201e-01 | 0.177 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.652201e-01 | 0.177 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.680378e-01 | 0.175 |
| R-HSA-5693538 | Homology Directed Repair | 6.708319e-01 | 0.173 |
| R-HSA-5688426 | Deubiquitination | 6.729884e-01 | 0.172 |
| R-HSA-69206 | G1/S Transition | 6.923604e-01 | 0.160 |
| R-HSA-8956319 | Nucleotide catabolism | 7.025945e-01 | 0.153 |
| R-HSA-1474165 | Reproduction | 7.075841e-01 | 0.150 |
| R-HSA-9658195 | Leishmania infection | 7.203836e-01 | 0.142 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.203836e-01 | 0.142 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.244022e-01 | 0.140 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.290285e-01 | 0.137 |
| R-HSA-5368287 | Mitochondrial translation | 7.290285e-01 | 0.137 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.313127e-01 | 0.136 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.424500e-01 | 0.129 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.446218e-01 | 0.128 |
| R-HSA-195721 | Signaling by WNT | 7.481705e-01 | 0.126 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.489111e-01 | 0.126 |
| R-HSA-2187338 | Visual phototransduction | 7.510289e-01 | 0.124 |
| R-HSA-69242 | S Phase | 7.531289e-01 | 0.123 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.572763e-01 | 0.121 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.613546e-01 | 0.118 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.613546e-01 | 0.118 |
| R-HSA-69306 | DNA Replication | 7.633682e-01 | 0.117 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.633682e-01 | 0.117 |
| R-HSA-6798695 | Neutrophil degranulation | 7.673723e-01 | 0.115 |
| R-HSA-9711097 | Cellular response to starvation | 7.731858e-01 | 0.112 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.769987e-01 | 0.110 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.770685e-01 | 0.110 |
| R-HSA-109581 | Apoptosis | 7.807479e-01 | 0.107 |
| R-HSA-1266738 | Developmental Biology | 7.809721e-01 | 0.107 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.844345e-01 | 0.105 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.985759e-01 | 0.098 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.002775e-01 | 0.097 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.019649e-01 | 0.096 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.019649e-01 | 0.096 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.052973e-01 | 0.094 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.180793e-01 | 0.087 |
| R-HSA-3781865 | Diseases of glycosylation | 8.196174e-01 | 0.086 |
| R-HSA-5617833 | Cilium Assembly | 8.285782e-01 | 0.082 |
| R-HSA-73894 | DNA Repair | 8.303506e-01 | 0.081 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.328914e-01 | 0.079 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.370970e-01 | 0.077 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.425413e-01 | 0.074 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.425413e-01 | 0.074 |
| R-HSA-428157 | Sphingolipid metabolism | 8.438740e-01 | 0.074 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.465057e-01 | 0.072 |
| R-HSA-382551 | Transport of small molecules | 8.512168e-01 | 0.070 |
| R-HSA-5663205 | Infectious disease | 8.609132e-01 | 0.065 |
| R-HSA-9748784 | Drug ADME | 8.660344e-01 | 0.062 |
| R-HSA-418990 | Adherens junctions interactions | 8.660344e-01 | 0.062 |
| R-HSA-8951664 | Neddylation | 8.694113e-01 | 0.061 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.790433e-01 | 0.056 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.860443e-01 | 0.053 |
| R-HSA-1643685 | Disease | 8.920749e-01 | 0.050 |
| R-HSA-72766 | Translation | 8.936421e-01 | 0.049 |
| R-HSA-421270 | Cell-cell junction organization | 8.988622e-01 | 0.046 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.030843e-01 | 0.044 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.087028e-01 | 0.042 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.210748e-01 | 0.036 |
| R-HSA-199991 | Membrane Trafficking | 9.224475e-01 | 0.035 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.439170e-01 | 0.025 |
| R-HSA-1280218 | Adaptive Immune System | 9.488561e-01 | 0.023 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.531542e-01 | 0.021 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.695103e-01 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.721930e-01 | 0.012 |
| R-HSA-5668914 | Diseases of metabolism | 9.778309e-01 | 0.010 |
| R-HSA-597592 | Post-translational protein modification | 9.898022e-01 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 9.945603e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.999681e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999745e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999830e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.838 | 0.206 | 2 | 0.882 |
PRPK |
0.822 | 0.067 | -1 | 0.814 |
CLK3 |
0.819 | 0.128 | 1 | 0.798 |
GCN2 |
0.818 | -0.046 | 2 | 0.787 |
ULK2 |
0.818 | 0.024 | 2 | 0.791 |
GRK1 |
0.818 | 0.150 | -2 | 0.743 |
DSTYK |
0.818 | 0.046 | 2 | 0.869 |
MOS |
0.816 | 0.075 | 1 | 0.807 |
MTOR |
0.815 | 0.036 | 1 | 0.781 |
TBK1 |
0.815 | -0.021 | 1 | 0.753 |
TGFBR2 |
0.815 | 0.037 | -2 | 0.751 |
CDC7 |
0.814 | -0.002 | 1 | 0.809 |
BMPR2 |
0.814 | 0.033 | -2 | 0.809 |
NEK6 |
0.814 | 0.046 | -2 | 0.807 |
NUAK2 |
0.814 | 0.046 | -3 | 0.727 |
IKKE |
0.813 | -0.031 | 1 | 0.749 |
WNK1 |
0.813 | 0.055 | -2 | 0.780 |
MST4 |
0.813 | 0.114 | 2 | 0.799 |
IKKB |
0.813 | -0.084 | -2 | 0.670 |
NLK |
0.812 | 0.031 | 1 | 0.790 |
KIS |
0.812 | 0.077 | 1 | 0.651 |
ATR |
0.811 | 0.068 | 1 | 0.858 |
MARK4 |
0.811 | 0.095 | 4 | 0.811 |
SRPK1 |
0.810 | 0.067 | -3 | 0.642 |
CAMK2G |
0.809 | -0.034 | 2 | 0.812 |
PIM3 |
0.809 | -0.016 | -3 | 0.729 |
RAF1 |
0.809 | -0.093 | 1 | 0.833 |
PRKD1 |
0.808 | 0.026 | -3 | 0.740 |
NDR2 |
0.808 | -0.006 | -3 | 0.741 |
CDKL1 |
0.808 | 0.005 | -3 | 0.684 |
NEK7 |
0.808 | -0.058 | -3 | 0.749 |
SKMLCK |
0.808 | 0.059 | -2 | 0.750 |
NIM1 |
0.807 | 0.115 | 3 | 0.725 |
PDHK1 |
0.807 | -0.128 | 1 | 0.836 |
PDHK4 |
0.807 | -0.201 | 1 | 0.834 |
AMPKA1 |
0.806 | 0.039 | -3 | 0.755 |
CAMK1B |
0.806 | -0.065 | -3 | 0.739 |
PKN2 |
0.806 | 0.034 | -3 | 0.731 |
ATM |
0.806 | 0.102 | 1 | 0.826 |
PKN3 |
0.806 | 0.002 | -3 | 0.719 |
ULK1 |
0.806 | -0.073 | -3 | 0.719 |
MLK1 |
0.805 | -0.035 | 2 | 0.785 |
RSK2 |
0.805 | 0.003 | -3 | 0.664 |
ERK5 |
0.805 | -0.008 | 1 | 0.738 |
HUNK |
0.804 | -0.011 | 2 | 0.813 |
TSSK2 |
0.804 | 0.041 | -5 | 0.730 |
PKCD |
0.804 | 0.065 | 2 | 0.769 |
GRK5 |
0.803 | -0.086 | -3 | 0.738 |
CHAK2 |
0.803 | -0.014 | -1 | 0.704 |
HIPK4 |
0.803 | 0.019 | 1 | 0.750 |
NEK9 |
0.803 | -0.008 | 2 | 0.825 |
RIPK3 |
0.803 | -0.048 | 3 | 0.693 |
TSSK1 |
0.802 | 0.044 | -3 | 0.783 |
BMPR1B |
0.802 | 0.106 | 1 | 0.770 |
IKKA |
0.802 | -0.027 | -2 | 0.674 |
CDKL5 |
0.802 | -0.001 | -3 | 0.681 |
FAM20C |
0.802 | 0.108 | 2 | 0.640 |
BCKDK |
0.802 | -0.080 | -1 | 0.726 |
GRK4 |
0.802 | -0.027 | -2 | 0.784 |
PRKD2 |
0.802 | -0.002 | -3 | 0.689 |
PRP4 |
0.802 | 0.280 | -3 | 0.854 |
NIK |
0.802 | -0.051 | -3 | 0.770 |
MAPKAPK3 |
0.801 | -0.041 | -3 | 0.683 |
CAMLCK |
0.801 | -0.040 | -2 | 0.724 |
GRK7 |
0.801 | 0.116 | 1 | 0.760 |
NDR1 |
0.801 | -0.036 | -3 | 0.728 |
SRPK2 |
0.801 | 0.040 | -3 | 0.560 |
SRPK3 |
0.800 | 0.048 | -3 | 0.599 |
RSK3 |
0.800 | -0.019 | -3 | 0.658 |
CAMK2D |
0.800 | -0.028 | -3 | 0.742 |
P90RSK |
0.800 | -0.022 | -3 | 0.666 |
DAPK2 |
0.799 | -0.032 | -3 | 0.752 |
IRE1 |
0.799 | 0.015 | 1 | 0.783 |
AMPKA2 |
0.799 | 0.013 | -3 | 0.722 |
MNK2 |
0.799 | 0.030 | -2 | 0.666 |
DNAPK |
0.799 | 0.149 | 1 | 0.766 |
TGFBR1 |
0.799 | 0.053 | -2 | 0.751 |
WNK3 |
0.799 | -0.148 | 1 | 0.810 |
GRK6 |
0.798 | -0.045 | 1 | 0.826 |
TTBK2 |
0.798 | -0.066 | 2 | 0.715 |
P70S6KB |
0.798 | -0.032 | -3 | 0.680 |
PKCA |
0.797 | 0.086 | 2 | 0.705 |
CDK8 |
0.797 | 0.003 | 1 | 0.635 |
PLK1 |
0.796 | -0.004 | -2 | 0.759 |
ALK4 |
0.796 | 0.003 | -2 | 0.769 |
QSK |
0.796 | 0.049 | 4 | 0.792 |
PKACG |
0.796 | -0.029 | -2 | 0.613 |
MASTL |
0.796 | -0.133 | -2 | 0.732 |
MLK3 |
0.795 | 0.004 | 2 | 0.711 |
PIM1 |
0.795 | -0.012 | -3 | 0.670 |
ANKRD3 |
0.795 | -0.087 | 1 | 0.854 |
SMG1 |
0.795 | 0.071 | 1 | 0.820 |
MLK2 |
0.795 | -0.056 | 2 | 0.797 |
CLK1 |
0.795 | 0.051 | -3 | 0.629 |
IRE2 |
0.795 | 0.011 | 2 | 0.764 |
PKCB |
0.795 | 0.055 | 2 | 0.714 |
MAPKAPK2 |
0.794 | -0.029 | -3 | 0.634 |
CAMK2B |
0.794 | 0.009 | 2 | 0.787 |
RIPK1 |
0.794 | -0.104 | 1 | 0.822 |
QIK |
0.794 | -0.011 | -3 | 0.721 |
CDK5 |
0.793 | 0.085 | 1 | 0.635 |
NEK2 |
0.793 | 0.006 | 2 | 0.797 |
LATS2 |
0.793 | -0.064 | -5 | 0.632 |
PKCG |
0.793 | 0.032 | 2 | 0.716 |
SGK3 |
0.793 | 0.040 | -3 | 0.665 |
DYRK2 |
0.793 | 0.031 | 1 | 0.653 |
PKR |
0.792 | 0.055 | 1 | 0.817 |
CDK19 |
0.792 | 0.008 | 1 | 0.595 |
NUAK1 |
0.792 | -0.042 | -3 | 0.674 |
ACVR2A |
0.792 | 0.016 | -2 | 0.748 |
PLK4 |
0.791 | 0.033 | 2 | 0.655 |
PKG2 |
0.791 | 0.001 | -2 | 0.544 |
CLK2 |
0.791 | 0.090 | -3 | 0.640 |
AURC |
0.791 | -0.016 | -2 | 0.519 |
ACVR2B |
0.791 | 0.020 | -2 | 0.763 |
MELK |
0.791 | -0.045 | -3 | 0.706 |
SIK |
0.791 | 0.011 | -3 | 0.643 |
MARK3 |
0.790 | 0.043 | 4 | 0.751 |
ICK |
0.790 | -0.057 | -3 | 0.723 |
MNK1 |
0.790 | 0.010 | -2 | 0.683 |
MARK2 |
0.790 | 0.038 | 4 | 0.727 |
ALK2 |
0.789 | 0.045 | -2 | 0.758 |
CLK4 |
0.789 | 0.006 | -3 | 0.643 |
YSK4 |
0.789 | -0.049 | 1 | 0.789 |
VRK2 |
0.789 | -0.030 | 1 | 0.859 |
CDK1 |
0.789 | 0.061 | 1 | 0.580 |
LATS1 |
0.789 | 0.019 | -3 | 0.748 |
PHKG1 |
0.789 | -0.057 | -3 | 0.724 |
DLK |
0.789 | -0.179 | 1 | 0.845 |
PAK1 |
0.789 | -0.053 | -2 | 0.639 |
PRKD3 |
0.788 | -0.048 | -3 | 0.634 |
CDK3 |
0.788 | 0.130 | 1 | 0.513 |
CDK13 |
0.788 | 0.021 | 1 | 0.595 |
PAK3 |
0.788 | -0.082 | -2 | 0.641 |
BRSK1 |
0.788 | -0.036 | -3 | 0.685 |
PAK6 |
0.788 | -0.015 | -2 | 0.548 |
MLK4 |
0.787 | -0.038 | 2 | 0.697 |
PKCH |
0.787 | -0.006 | 2 | 0.710 |
CDK7 |
0.787 | -0.017 | 1 | 0.619 |
PKCZ |
0.786 | 0.000 | 2 | 0.775 |
BRSK2 |
0.786 | -0.057 | -3 | 0.713 |
CDK2 |
0.786 | 0.078 | 1 | 0.662 |
CHAK1 |
0.785 | -0.065 | 2 | 0.770 |
RSK4 |
0.785 | -0.018 | -3 | 0.633 |
PLK3 |
0.785 | -0.052 | 2 | 0.773 |
CAMK4 |
0.785 | -0.137 | -3 | 0.702 |
MST3 |
0.785 | 0.108 | 2 | 0.795 |
JNK3 |
0.785 | 0.027 | 1 | 0.605 |
CAMK2A |
0.785 | -0.043 | 2 | 0.780 |
P38A |
0.785 | 0.023 | 1 | 0.647 |
PKACB |
0.784 | -0.008 | -2 | 0.541 |
HRI |
0.784 | -0.063 | -2 | 0.787 |
MEKK1 |
0.784 | 0.031 | 1 | 0.833 |
TLK2 |
0.784 | -0.041 | 1 | 0.815 |
JNK2 |
0.784 | 0.039 | 1 | 0.572 |
WNK4 |
0.784 | -0.019 | -2 | 0.776 |
MSK2 |
0.784 | -0.085 | -3 | 0.627 |
ZAK |
0.783 | -0.003 | 1 | 0.830 |
TAO3 |
0.783 | 0.092 | 1 | 0.801 |
CDK12 |
0.783 | 0.032 | 1 | 0.574 |
MEKK2 |
0.783 | 0.045 | 2 | 0.792 |
IRAK4 |
0.783 | 0.012 | 1 | 0.808 |
PERK |
0.783 | -0.070 | -2 | 0.785 |
CDK18 |
0.783 | 0.042 | 1 | 0.550 |
HIPK1 |
0.782 | 0.027 | 1 | 0.672 |
SSTK |
0.782 | 0.012 | 4 | 0.785 |
DCAMKL1 |
0.782 | -0.002 | -3 | 0.690 |
AKT2 |
0.782 | -0.015 | -3 | 0.577 |
P38G |
0.781 | 0.035 | 1 | 0.497 |
P38B |
0.781 | 0.022 | 1 | 0.579 |
MEK1 |
0.781 | -0.171 | 2 | 0.814 |
MARK1 |
0.780 | -0.013 | 4 | 0.769 |
MPSK1 |
0.780 | 0.088 | 1 | 0.737 |
CK1E |
0.780 | -0.024 | -3 | 0.426 |
PKCT |
0.780 | 0.005 | 2 | 0.721 |
BMPR1A |
0.780 | 0.040 | 1 | 0.758 |
MEKK3 |
0.780 | -0.064 | 1 | 0.812 |
AURB |
0.780 | -0.057 | -2 | 0.511 |
BRAF |
0.779 | -0.037 | -4 | 0.776 |
NEK5 |
0.779 | 0.006 | 1 | 0.826 |
HIPK2 |
0.779 | 0.022 | 1 | 0.561 |
CDK9 |
0.779 | -0.004 | 1 | 0.606 |
MSK1 |
0.778 | -0.064 | -3 | 0.636 |
TAO2 |
0.778 | 0.074 | 2 | 0.834 |
DRAK1 |
0.778 | -0.062 | 1 | 0.754 |
SNRK |
0.778 | -0.160 | 2 | 0.685 |
MYLK4 |
0.777 | -0.091 | -2 | 0.639 |
MAPKAPK5 |
0.777 | -0.134 | -3 | 0.609 |
PAK2 |
0.777 | -0.115 | -2 | 0.620 |
PIM2 |
0.777 | -0.033 | -3 | 0.632 |
PRKX |
0.777 | -0.000 | -3 | 0.582 |
AKT1 |
0.777 | -0.006 | -3 | 0.604 |
GRK2 |
0.777 | -0.078 | -2 | 0.653 |
HIPK3 |
0.776 | -0.006 | 1 | 0.670 |
AURA |
0.776 | -0.058 | -2 | 0.480 |
CHK1 |
0.776 | -0.100 | -3 | 0.732 |
ERK1 |
0.776 | -0.013 | 1 | 0.571 |
TLK1 |
0.775 | -0.100 | -2 | 0.791 |
MEK5 |
0.775 | -0.146 | 2 | 0.802 |
PHKG2 |
0.775 | -0.053 | -3 | 0.686 |
CDK17 |
0.775 | 0.011 | 1 | 0.500 |
TNIK |
0.774 | 0.153 | 3 | 0.863 |
IRAK1 |
0.774 | -0.104 | -1 | 0.682 |
EEF2K |
0.774 | 0.109 | 3 | 0.850 |
DYRK1A |
0.774 | -0.028 | 1 | 0.693 |
TTBK1 |
0.774 | -0.107 | 2 | 0.638 |
HGK |
0.773 | 0.102 | 3 | 0.862 |
PKACA |
0.772 | -0.027 | -2 | 0.490 |
DYRK4 |
0.772 | 0.013 | 1 | 0.574 |
P38D |
0.772 | 0.027 | 1 | 0.518 |
SMMLCK |
0.772 | -0.071 | -3 | 0.697 |
DCAMKL2 |
0.772 | -0.056 | -3 | 0.701 |
PDK1 |
0.771 | -0.005 | 1 | 0.795 |
CK1D |
0.771 | -0.032 | -3 | 0.379 |
MAP3K15 |
0.771 | 0.077 | 1 | 0.805 |
PKCI |
0.771 | -0.019 | 2 | 0.733 |
PKCE |
0.771 | 0.026 | 2 | 0.701 |
MINK |
0.770 | 0.092 | 1 | 0.800 |
DYRK1B |
0.770 | -0.007 | 1 | 0.601 |
CAMK1G |
0.768 | -0.107 | -3 | 0.639 |
NEK11 |
0.768 | -0.068 | 1 | 0.810 |
CK1G1 |
0.768 | -0.065 | -3 | 0.407 |
CK2A2 |
0.768 | 0.045 | 1 | 0.609 |
MEKK6 |
0.768 | 0.038 | 1 | 0.808 |
ERK2 |
0.768 | -0.062 | 1 | 0.623 |
PINK1 |
0.768 | -0.180 | 1 | 0.778 |
P70S6K |
0.768 | -0.083 | -3 | 0.590 |
ERK7 |
0.767 | 0.023 | 2 | 0.531 |
DYRK3 |
0.767 | -0.023 | 1 | 0.680 |
CAMKK1 |
0.767 | -0.110 | -2 | 0.671 |
CDK16 |
0.767 | 0.032 | 1 | 0.515 |
GSK3A |
0.767 | 0.011 | 4 | 0.415 |
GCK |
0.766 | 0.051 | 1 | 0.786 |
GRK3 |
0.766 | -0.066 | -2 | 0.621 |
CK1A2 |
0.766 | -0.050 | -3 | 0.376 |
PAK5 |
0.766 | -0.065 | -2 | 0.483 |
VRK1 |
0.766 | 0.019 | 2 | 0.874 |
NEK4 |
0.766 | -0.044 | 1 | 0.798 |
GSK3B |
0.766 | -0.035 | 4 | 0.404 |
CDK14 |
0.766 | -0.001 | 1 | 0.598 |
CDK10 |
0.765 | 0.018 | 1 | 0.581 |
GAK |
0.765 | -0.034 | 1 | 0.782 |
PKN1 |
0.765 | -0.036 | -3 | 0.613 |
HPK1 |
0.764 | 0.040 | 1 | 0.781 |
AKT3 |
0.764 | -0.011 | -3 | 0.528 |
CDK6 |
0.764 | 0.042 | 1 | 0.576 |
KHS1 |
0.764 | 0.098 | 1 | 0.781 |
NEK8 |
0.763 | -0.145 | 2 | 0.804 |
PAK4 |
0.763 | -0.057 | -2 | 0.483 |
SGK1 |
0.763 | -0.004 | -3 | 0.505 |
NEK1 |
0.763 | 0.012 | 1 | 0.803 |
LKB1 |
0.762 | -0.041 | -3 | 0.787 |
YSK1 |
0.762 | 0.065 | 2 | 0.782 |
PASK |
0.762 | -0.089 | -3 | 0.742 |
DAPK3 |
0.762 | -0.041 | -3 | 0.686 |
KHS2 |
0.762 | 0.107 | 1 | 0.786 |
MST2 |
0.762 | -0.054 | 1 | 0.808 |
LRRK2 |
0.761 | -0.051 | 2 | 0.837 |
PLK2 |
0.760 | -0.040 | -3 | 0.667 |
CAMKK2 |
0.760 | -0.140 | -2 | 0.655 |
JNK1 |
0.759 | -0.010 | 1 | 0.547 |
CAMK1D |
0.759 | -0.093 | -3 | 0.580 |
TAK1 |
0.758 | -0.090 | 1 | 0.826 |
CDK4 |
0.758 | 0.012 | 1 | 0.557 |
LOK |
0.757 | -0.046 | -2 | 0.675 |
BUB1 |
0.757 | 0.021 | -5 | 0.636 |
MAK |
0.757 | 0.016 | -2 | 0.597 |
CHK2 |
0.756 | -0.066 | -3 | 0.530 |
ROCK2 |
0.756 | -0.005 | -3 | 0.683 |
MRCKB |
0.756 | -0.038 | -3 | 0.626 |
CK2A1 |
0.755 | 0.016 | 1 | 0.586 |
MST1 |
0.754 | -0.068 | 1 | 0.793 |
DAPK1 |
0.754 | -0.068 | -3 | 0.663 |
RIPK2 |
0.753 | -0.187 | 1 | 0.785 |
TAO1 |
0.753 | 0.058 | 1 | 0.756 |
STK33 |
0.753 | -0.109 | 2 | 0.610 |
NEK3 |
0.752 | -0.036 | 1 | 0.786 |
OSR1 |
0.752 | 0.005 | 2 | 0.767 |
ASK1 |
0.751 | 0.029 | 1 | 0.800 |
HASPIN |
0.751 | 0.003 | -1 | 0.592 |
MRCKA |
0.750 | -0.067 | -3 | 0.639 |
PKG1 |
0.749 | -0.064 | -2 | 0.477 |
MOK |
0.749 | -0.019 | 1 | 0.674 |
MYO3B |
0.749 | 0.081 | 2 | 0.794 |
TTK |
0.749 | 0.013 | -2 | 0.775 |
MEK2 |
0.749 | -0.172 | 2 | 0.800 |
PDHK3_TYR |
0.748 | 0.131 | 4 | 0.873 |
DMPK1 |
0.748 | -0.014 | -3 | 0.650 |
SLK |
0.747 | -0.108 | -2 | 0.630 |
SBK |
0.747 | -0.051 | -3 | 0.472 |
CAMK1A |
0.747 | -0.096 | -3 | 0.550 |
PKMYT1_TYR |
0.746 | 0.132 | 3 | 0.817 |
EPHA6 |
0.745 | 0.125 | -1 | 0.807 |
PBK |
0.745 | -0.052 | 1 | 0.686 |
MYO3A |
0.743 | 0.028 | 1 | 0.787 |
ROCK1 |
0.742 | -0.039 | -3 | 0.645 |
ALPHAK3 |
0.741 | -0.034 | -1 | 0.744 |
TESK1_TYR |
0.741 | -0.014 | 3 | 0.843 |
BMPR2_TYR |
0.740 | 0.021 | -1 | 0.828 |
MAP2K4_TYR |
0.740 | -0.016 | -1 | 0.834 |
CSF1R |
0.739 | 0.056 | 3 | 0.787 |
EPHB4 |
0.739 | 0.068 | -1 | 0.796 |
MAP2K7_TYR |
0.739 | -0.071 | 2 | 0.844 |
TYK2 |
0.738 | 0.023 | 1 | 0.821 |
JAK2 |
0.738 | 0.041 | 1 | 0.824 |
LIMK2_TYR |
0.738 | 0.036 | -3 | 0.813 |
BIKE |
0.738 | -0.027 | 1 | 0.650 |
ABL2 |
0.738 | 0.067 | -1 | 0.778 |
CRIK |
0.738 | -0.044 | -3 | 0.605 |
MST1R |
0.737 | 0.009 | 3 | 0.796 |
PINK1_TYR |
0.737 | -0.092 | 1 | 0.818 |
RET |
0.737 | -0.029 | 1 | 0.819 |
ROS1 |
0.736 | 0.040 | 3 | 0.758 |
TYRO3 |
0.736 | 0.021 | 3 | 0.799 |
MAP2K6_TYR |
0.735 | -0.056 | -1 | 0.813 |
JAK1 |
0.734 | 0.085 | 1 | 0.784 |
PDHK4_TYR |
0.734 | -0.041 | 2 | 0.851 |
HCK |
0.734 | 0.036 | -1 | 0.808 |
ITK |
0.733 | 0.046 | -1 | 0.785 |
LCK |
0.732 | 0.059 | -1 | 0.809 |
LIMK1_TYR |
0.732 | -0.065 | 2 | 0.848 |
ABL1 |
0.732 | 0.030 | -1 | 0.774 |
TXK |
0.732 | 0.069 | 1 | 0.775 |
PDHK1_TYR |
0.732 | -0.098 | -1 | 0.818 |
KIT |
0.731 | -0.001 | 3 | 0.791 |
CK1A |
0.730 | -0.074 | -3 | 0.294 |
JAK3 |
0.730 | -0.024 | 1 | 0.812 |
BLK |
0.730 | 0.077 | -1 | 0.803 |
EPHB1 |
0.729 | 0.011 | 1 | 0.845 |
SRMS |
0.729 | 0.030 | 1 | 0.827 |
BMX |
0.729 | 0.040 | -1 | 0.739 |
YES1 |
0.729 | -0.019 | -1 | 0.797 |
TEC |
0.728 | 0.038 | -1 | 0.745 |
TNNI3K_TYR |
0.728 | 0.095 | 1 | 0.827 |
YANK3 |
0.728 | -0.086 | 2 | 0.397 |
FER |
0.728 | -0.020 | 1 | 0.828 |
DDR1 |
0.728 | -0.081 | 4 | 0.817 |
EPHB3 |
0.728 | 0.024 | -1 | 0.783 |
FLT3 |
0.728 | -0.030 | 3 | 0.794 |
EPHB2 |
0.727 | 0.021 | -1 | 0.783 |
TNK2 |
0.727 | 0.044 | 3 | 0.741 |
EPHA4 |
0.727 | 0.006 | 2 | 0.761 |
STLK3 |
0.726 | -0.146 | 1 | 0.791 |
PDGFRB |
0.726 | -0.037 | 3 | 0.799 |
MERTK |
0.726 | 0.023 | 3 | 0.736 |
WEE1_TYR |
0.726 | 0.015 | -1 | 0.732 |
FGR |
0.726 | -0.059 | 1 | 0.797 |
INSRR |
0.725 | -0.051 | 3 | 0.724 |
ALK |
0.725 | 0.000 | 3 | 0.731 |
BTK |
0.724 | -0.039 | -1 | 0.757 |
KDR |
0.724 | -0.039 | 3 | 0.734 |
MET |
0.724 | -0.009 | 3 | 0.769 |
AAK1 |
0.724 | 0.012 | 1 | 0.542 |
TEK |
0.724 | -0.045 | 3 | 0.728 |
FGFR2 |
0.723 | -0.067 | 3 | 0.749 |
AXL |
0.723 | -0.011 | 3 | 0.749 |
FRK |
0.723 | 0.014 | -1 | 0.811 |
TNK1 |
0.723 | -0.019 | 3 | 0.761 |
FYN |
0.722 | 0.022 | -1 | 0.792 |
EPHA7 |
0.722 | 0.018 | 2 | 0.771 |
LYN |
0.722 | 0.007 | 3 | 0.719 |
PDGFRA |
0.721 | -0.074 | 3 | 0.805 |
LTK |
0.721 | -0.024 | 3 | 0.739 |
FGFR1 |
0.721 | -0.073 | 3 | 0.749 |
EPHA1 |
0.721 | 0.008 | 3 | 0.751 |
NEK10_TYR |
0.719 | -0.067 | 1 | 0.702 |
PTK6 |
0.717 | -0.108 | -1 | 0.732 |
ERBB2 |
0.715 | -0.095 | 1 | 0.771 |
PTK2B |
0.715 | 0.009 | -1 | 0.751 |
EPHA3 |
0.714 | -0.067 | 2 | 0.742 |
INSR |
0.713 | -0.086 | 3 | 0.706 |
FLT1 |
0.713 | -0.091 | -1 | 0.784 |
DDR2 |
0.712 | 0.005 | 3 | 0.725 |
NTRK1 |
0.712 | -0.124 | -1 | 0.764 |
NTRK2 |
0.712 | -0.119 | 3 | 0.737 |
SRC |
0.712 | -0.029 | -1 | 0.790 |
MATK |
0.711 | -0.053 | -1 | 0.698 |
EGFR |
0.711 | -0.034 | 1 | 0.700 |
EPHA5 |
0.711 | -0.018 | 2 | 0.755 |
NTRK3 |
0.711 | -0.061 | -1 | 0.729 |
FGFR3 |
0.711 | -0.111 | 3 | 0.726 |
EPHA8 |
0.710 | -0.026 | -1 | 0.777 |
FLT4 |
0.708 | -0.135 | 3 | 0.715 |
CSK |
0.708 | -0.080 | 2 | 0.768 |
CK1G3 |
0.708 | -0.097 | -3 | 0.249 |
FGFR4 |
0.706 | -0.052 | -1 | 0.751 |
SYK |
0.705 | 0.012 | -1 | 0.749 |
EPHA2 |
0.705 | -0.015 | -1 | 0.760 |
MUSK |
0.703 | -0.074 | 1 | 0.679 |
PTK2 |
0.702 | -0.007 | -1 | 0.746 |
IGF1R |
0.700 | -0.085 | 3 | 0.647 |
ERBB4 |
0.698 | -0.036 | 1 | 0.705 |
YANK2 |
0.695 | -0.114 | 2 | 0.410 |
CK1G2 |
0.693 | -0.084 | -3 | 0.334 |
FES |
0.692 | -0.056 | -1 | 0.718 |
ZAP70 |
0.688 | -0.013 | -1 | 0.684 |