Motif 620 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQV5 | None | S26 | ochoa | Eukaryotic translation initiation factor 6 | None |
| O00418 | EEF2K | S445 | ochoa|psp | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O00592 | PODXL | S520 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O14640 | DVL1 | S51 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14641 | DVL2 | S59 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14776 | TCERG1 | S933 | ochoa | Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}. |
| O60449 | LY75 | S1702 | ochoa | Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}. |
| O60832 | DKC1 | S420 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75167 | PHACTR2 | S423 | ochoa | Phosphatase and actin regulator 2 | None |
| O75410 | TACC1 | S94 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O95376 | ARIH2 | S335 | ochoa | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}. |
| O95405 | ZFYVE9 | S48 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| O95409 | ZIC2 | S406 | ochoa | Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2) | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. |
| P04406 | GAPDH | S83 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P07900 | HSP90AA1 | T195 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08133 | ANXA6 | S630 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P08238 | HSP90AB1 | T190 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S482 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10109 | FDX1 | S159 | ochoa | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| P10398 | ARAF | S458 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10721 | KIT | S821 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P10909 | CLU | S394 | ochoa|psp | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17407782, PubMed:17412999). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex (PubMed:2780565, PubMed:1903064, PubMed:2601725, PubMed:2721499, PubMed:1551440, PubMed:9200695, PubMed:34667172). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:1903064, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2601725, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:9200695}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}. |
| P12883 | MYH7 | S851 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P18031 | PTPN1 | S242 | psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P22234 | PAICS | S107 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P25788 | PSMA3 | S34 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P26358 | DNMT1 | S549 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P26951 | IL3RA | S348 | ochoa | Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123) | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:10527461, ECO:0000269|PubMed:29374162}. |
| P29375 | KDM5A | S970 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P31327 | CPS1 | S148 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P41235 | HNF4A | S190 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P41250 | GARS1 | S335 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P42575 | CASP2 | S164 | ochoa|psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46736 | BRCC3 | Y54 | ochoa | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:16707425, PubMed:17525341, PubMed:19202061, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46737, ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}. |
| P49792 | RANBP2 | S1374 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49795 | RGS19 | S72 | ochoa | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| P51531 | SMARCA2 | S700 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52179 | MYOM1 | S999 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52565 | ARHGDIA | S96 | psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P54792 | DVL1P1 | S51 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P54819 | AK2 | S151 | ochoa | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| P55072 | VCP | S702 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56537 | EIF6 | S174 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
| P62736 | ACTA2 | S91 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63267 | ACTG2 | S90 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78347 | GTF2I | S231 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q13347 | EIF3I | S301 | ochoa | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q13393 | PLD1 | S22 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q14789 | GOLGB1 | S1133 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14966 | ZNF638 | S278 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15915 | ZIC1 | S375 | ochoa | Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1) | Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). {ECO:0000250|UniProtKB:P46684}. |
| Q2M1Z3 | ARHGAP31 | S346 | ochoa|psp | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q4G0X9 | CCDC40 | S214 | ochoa | Coiled-coil domain-containing protein 40 | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}. |
| Q58FF7 | HSP90AB3P | T169 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S258 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5EBL4 | RILPL1 | S259 | ochoa | RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) | Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). {ECO:0000250|UniProtKB:D3ZUQ0, ECO:0000250|UniProtKB:Q9JJC6, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:30398148}. |
| Q5H9R7 | PPP6R3 | S523 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5HY98 | ZNF766 | S144 | ochoa | Zinc finger protein 766 | May be involved in transcriptional regulation. |
| Q5T0W9 | FAM83B | S542 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T655 | CFAP58 | S146 | ochoa | Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) | Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RW38, ECO:0000269|PubMed:32791035}. |
| Q5THJ4 | VPS13D | S3802 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VUB5 | FAM171A1 | S426 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q6IQ55 | TTBK2 | S781 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6ZS30 | NBEAL1 | S1841 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q86T82 | USP37 | S301 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
| Q86U70 | LDB1 | S332 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q8IW50 | FAM219A | S28 | ochoa | Protein FAM219A | None |
| Q8IY81 | FTSJ3 | S598 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8N3S3 | PHTF2 | S331 | ochoa | Protein PHTF2 | None |
| Q8N5D0 | WDTC1 | S353 | ochoa | WD and tetratricopeptide repeats protein 1 | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}. |
| Q8NCA9 | ZNF784 | S40 | ochoa | Zinc finger protein 784 | May be involved in transcriptional regulation. |
| Q8NFZ8 | CADM4 | S361 | ochoa | Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) | Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. {ECO:0000269|PubMed:16261159}. |
| Q8NI35 | PATJ | S781 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q92997 | DVL3 | S48 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q92997 | DVL3 | S311 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969K3 | RNF34 | S284 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96AC1 | FERMT2 | S332 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96B18 | DACT3 | S165 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96FV2 | SCRN2 | S55 | ochoa | Secernin-2 | None |
| Q96GX9 | APIP | S61 | ochoa | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}. |
| Q96HE9 | PRR11 | S307 | ochoa | Proline-rich protein 11 | Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}. |
| Q96KS0 | EGLN2 | S234 | psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96PN7 | TRERF1 | S619 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96TC7 | RMDN3 | S193 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q9BQE5 | APOL2 | S187 | ochoa | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. |
| Q9BRQ6 | CHCHD6 | S75 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BWM7 | SFXN3 | S290 | ochoa | Sideroflexin-3 | Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}. |
| Q9BXL6 | CARD14 | S259 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BYE7 | PCGF6 | S232 | ochoa | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}. |
| Q9C0K0 | BCL11B | S101 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H171 | ZBP1 | S27 | ochoa | Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1) | Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (By similarity). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (By similarity). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (By similarity). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). {ECO:0000250|UniProtKB:Q9QY24, ECO:0000269|PubMed:32200799}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9H246 | C1orf21 | S95 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
| Q9H7C9 | AAMDC | S46 | ochoa | Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein) | May play a role in preadipocyte differentiation and adipogenesis. {ECO:0000250}. |
| Q9HAZ2 | PRDM16 | S436 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HB19 | PLEKHA2 | S352 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9NQT8 | KIF13B | S1293 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NVW2 | RLIM | S248 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NZQ7 | CD274 | S195 | psp | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9P2D1 | CHD7 | S2159 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UGL1 | KDM5B | S986 | ochoa | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UJA3 | MCM8 | S633 | ochoa | DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. |
| Q9UKY1 | ZHX1 | S26 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UMS6 | SYNPO2 | S263 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPR3 | SMG5 | S415 | ochoa | Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}. |
| Q9UQ35 | SRRM2 | S1233 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y6X4 | FAM169A | S526 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| Q58FF6 | HSP90AB4P | T165 | Sugiyama | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q96RT7 | TUBGCP6 | S392 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| O15111 | CHUK | S579 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O43852 | CALU | Y185 | Sugiyama | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| Q12906 | ILF3 | S19 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| P07333 | CSF1R | S807 | Sugiyama | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}. |
| P07947 | YES1 | Y473 | Sugiyama | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P14625 | HSP90B1 | S256 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P08631 | HCK | S130 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P09769 | FGR | Y459 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P16234 | PDGFRA | S847 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| Q01518 | CAP1 | S431 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| P36888 | FLT3 | S840 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P28074 | PSMB5 | S175 | Sugiyama | Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O95372 | LYPLA2 | S212 | Sugiyama | Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) | Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). {ECO:0000269|PubMed:21152083, ECO:0000269|PubMed:25301951, ECO:0000269|PubMed:28826475}. |
| Q9Y262 | EIF3L | S80 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P09960 | LTA4H | S581 | Sugiyama | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
| Q9H3Y6 | SRMS | S293 | Sugiyama | Tyrosine-protein kinase Srms (EC 2.7.10.2) | Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907, ECO:0000269|PubMed:35927303}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.000016 | 4.806 |
| R-HSA-4641258 | Degradation of DVL | 0.000063 | 4.202 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000042 | 4.378 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.000206 | 3.686 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.000342 | 3.465 |
| R-HSA-9664420 | Killing mechanisms | 0.000904 | 3.044 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.000904 | 3.044 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.000780 | 3.108 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.009211 | 2.036 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 0.009211 | 2.036 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.009211 | 2.036 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 0.009211 | 2.036 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 0.009211 | 2.036 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 0.009211 | 2.036 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 0.009211 | 2.036 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 0.009211 | 2.036 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 0.009211 | 2.036 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.009211 | 2.036 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.009211 | 2.036 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.001476 | 2.831 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.001997 | 2.700 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.006764 | 2.170 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.002475 | 2.606 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.009084 | 2.042 |
| R-HSA-4086400 | PCP/CE pathway | 0.001315 | 2.881 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.003721 | 2.429 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.006792 | 2.168 |
| R-HSA-3371511 | HSF1 activation | 0.007699 | 2.114 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.006642 | 2.178 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.003291 | 2.483 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.004002 | 2.398 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.005694 | 2.245 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.008737 | 2.059 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.004272 | 2.369 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.007392 | 2.131 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.002273 | 2.643 |
| R-HSA-1266738 | Developmental Biology | 0.003997 | 2.398 |
| R-HSA-9758941 | Gastrulation | 0.004851 | 2.314 |
| R-HSA-186712 | Regulation of beta-cell development | 0.003663 | 2.436 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.009239 | 2.034 |
| R-HSA-201556 | Signaling by ALK | 0.009239 | 2.034 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.010358 | 1.985 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.010358 | 1.985 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.010358 | 1.985 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.011732 | 1.931 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.011553 | 1.937 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.011088 | 1.955 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.012178 | 1.914 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.012356 | 1.908 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.013488 | 1.870 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.013488 | 1.870 |
| R-HSA-9907900 | Proteasome assembly | 0.012823 | 1.892 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.013488 | 1.870 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.012823 | 1.892 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.013685 | 1.864 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.013685 | 1.864 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.013685 | 1.864 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.014860 | 1.828 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.014171 | 1.849 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.014384 | 1.842 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.015596 | 1.807 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.016518 | 1.782 |
| R-HSA-1483148 | Synthesis of PG | 0.016518 | 1.782 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.016518 | 1.782 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.016777 | 1.775 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.018680 | 1.729 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.017880 | 1.748 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.017880 | 1.748 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.017880 | 1.748 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.019500 | 1.710 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.019578 | 1.708 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.019578 | 1.708 |
| R-HSA-9831926 | Nephron development | 0.019578 | 1.708 |
| R-HSA-72649 | Translation initiation complex formation | 0.020340 | 1.692 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.022079 | 1.656 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.021191 | 1.674 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.021508 | 1.667 |
| R-HSA-9834899 | Specification of the neural plate border | 0.021191 | 1.674 |
| R-HSA-9658195 | Leishmania infection | 0.022608 | 1.646 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.022608 | 1.646 |
| R-HSA-446728 | Cell junction organization | 0.021556 | 1.666 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.022856 | 1.641 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.022856 | 1.641 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.023896 | 1.622 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.027380 | 1.563 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.027380 | 1.563 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.027380 | 1.563 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.027380 | 1.563 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.027380 | 1.563 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.028162 | 1.550 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.028162 | 1.550 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.025983 | 1.585 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.025588 | 1.592 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.025303 | 1.597 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.025303 | 1.597 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.024574 | 1.610 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.028407 | 1.547 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.029819 | 1.526 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.036340 | 1.440 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.036340 | 1.440 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.036340 | 1.440 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.036340 | 1.440 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.036340 | 1.440 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.036340 | 1.440 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.036340 | 1.440 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.036340 | 1.440 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.036340 | 1.440 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.036340 | 1.440 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.036340 | 1.440 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.034159 | 1.466 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.033909 | 1.470 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.033909 | 1.470 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.030875 | 1.510 |
| R-HSA-3214842 | HDMs demethylate histones | 0.033909 | 1.470 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.034999 | 1.456 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.035918 | 1.445 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.036445 | 1.438 |
| R-HSA-3371556 | Cellular response to heat stress | 0.037503 | 1.426 |
| R-HSA-1500931 | Cell-Cell communication | 0.037607 | 1.425 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.039228 | 1.406 |
| R-HSA-209563 | Axonal growth stimulation | 0.045218 | 1.345 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.054014 | 1.267 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.062731 | 1.203 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.062731 | 1.203 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.071367 | 1.147 |
| R-HSA-9645135 | STAT5 Activation | 0.079925 | 1.097 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.079925 | 1.097 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.079925 | 1.097 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.088404 | 1.054 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.096805 | 1.014 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.096805 | 1.014 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.137673 | 0.861 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.042210 | 1.375 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.161306 | 0.792 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.161306 | 0.792 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.169040 | 0.772 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.184296 | 0.734 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.184296 | 0.734 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.150258 | 0.823 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.172952 | 0.762 |
| R-HSA-380287 | Centrosome maturation | 0.179537 | 0.746 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.081558 | 1.089 |
| R-HSA-9607240 | FLT3 Signaling | 0.073527 | 1.134 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.040069 | 1.397 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.060768 | 1.216 |
| R-HSA-166665 | Terminal pathway of complement | 0.071367 | 1.147 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.169040 | 0.772 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.054014 | 1.267 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.062731 | 1.203 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.071367 | 1.147 |
| R-HSA-6798695 | Neutrophil degranulation | 0.156211 | 0.806 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.062809 | 1.202 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.169040 | 0.772 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.062731 | 1.203 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.071367 | 1.147 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.071367 | 1.147 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.088404 | 1.054 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.105130 | 0.978 |
| R-HSA-192905 | vRNP Assembly | 0.121551 | 0.915 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.137673 | 0.861 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.145623 | 0.837 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.046616 | 1.331 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.055902 | 1.253 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.089845 | 1.047 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.072904 | 1.137 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.076197 | 1.118 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.120433 | 0.919 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.076197 | 1.118 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.120433 | 0.919 |
| R-HSA-114608 | Platelet degranulation | 0.043738 | 1.359 |
| R-HSA-205025 | NADE modulates death signalling | 0.054014 | 1.267 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.096805 | 1.014 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.113378 | 0.945 |
| R-HSA-9018681 | Biosynthesis of protectins | 0.153501 | 0.814 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.048879 | 1.311 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.161306 | 0.792 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.058317 | 1.234 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.058317 | 1.234 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.191819 | 0.717 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.076174 | 1.118 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.076174 | 1.118 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.078852 | 1.103 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.092661 | 1.033 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.107108 | 0.970 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.110067 | 0.958 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.100999 | 0.996 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.100999 | 0.996 |
| R-HSA-180786 | Extension of Telomeres | 0.128247 | 0.892 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.102882 | 0.988 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.040018 | 1.398 |
| R-HSA-8951664 | Neddylation | 0.185407 | 0.732 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.079925 | 1.097 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.105130 | 0.978 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.137673 | 0.861 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.176703 | 0.753 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.068326 | 1.165 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.070911 | 1.149 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.070911 | 1.149 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.073527 | 1.134 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.050521 | 1.297 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.040560 | 1.392 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.063424 | 1.198 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.123459 | 0.908 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.191819 | 0.717 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.054565 | 1.263 |
| R-HSA-1280218 | Adaptive Immune System | 0.189706 | 0.722 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.054014 | 1.267 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.088404 | 1.054 |
| R-HSA-176974 | Unwinding of DNA | 0.105130 | 0.978 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.137673 | 0.861 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.137673 | 0.861 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.137673 | 0.861 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.137673 | 0.861 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.153501 | 0.814 |
| R-HSA-9857492 | Protein lipoylation | 0.161306 | 0.792 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.060768 | 1.216 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.060768 | 1.216 |
| R-HSA-4641257 | Degradation of AXIN | 0.063253 | 1.199 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.063253 | 1.199 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.104172 | 0.982 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.113047 | 0.947 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.174153 | 0.759 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.086461 | 1.063 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.082617 | 1.083 |
| R-HSA-195721 | Signaling by WNT | 0.173407 | 0.761 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.176703 | 0.753 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.077868 | 1.109 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.190256 | 0.721 |
| R-HSA-69481 | G2/M Checkpoints | 0.043738 | 1.359 |
| R-HSA-164944 | Nef and signal transduction | 0.079925 | 1.097 |
| R-HSA-111458 | Formation of apoptosome | 0.113378 | 0.945 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.121551 | 0.915 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.153501 | 0.814 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.161306 | 0.792 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.053523 | 1.271 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.055902 | 1.253 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.055902 | 1.253 |
| R-HSA-169911 | Regulation of Apoptosis | 0.058317 | 1.234 |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 0.184296 | 0.734 |
| R-HSA-3371568 | Attenuation phase | 0.070911 | 1.149 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.076174 | 1.118 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.076174 | 1.118 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.101258 | 0.995 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.163154 | 0.787 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.100999 | 0.996 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.046616 | 1.331 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.053151 | 1.274 |
| R-HSA-69275 | G2/M Transition | 0.042737 | 1.369 |
| R-HSA-5689603 | UCH proteinases | 0.182844 | 0.738 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.044226 | 1.354 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.116951 | 0.932 |
| R-HSA-5619084 | ABC transporter disorders | 0.046352 | 1.334 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.131343 | 0.882 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.071367 | 1.147 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.113378 | 0.945 |
| R-HSA-5689877 | Josephin domain DUBs | 0.113378 | 0.945 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.129649 | 0.887 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.153501 | 0.814 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.184296 | 0.734 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.070911 | 1.149 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.073527 | 1.134 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.110067 | 0.958 |
| R-HSA-202424 | Downstream TCR signaling | 0.064962 | 1.187 |
| R-HSA-2029481 | FCGR activation | 0.071282 | 1.147 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.137619 | 0.861 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.073527 | 1.134 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.116048 | 0.935 |
| R-HSA-9843745 | Adipogenesis | 0.156263 | 0.806 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.166409 | 0.779 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.166409 | 0.779 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.040108 | 1.397 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.084711 | 1.072 |
| R-HSA-69239 | Synthesis of DNA | 0.099131 | 1.004 |
| R-HSA-69206 | G1/S Transition | 0.141122 | 0.850 |
| R-HSA-210990 | PECAM1 interactions | 0.121551 | 0.915 |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 0.153501 | 0.814 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.084293 | 1.074 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.134793 | 0.870 |
| R-HSA-1640170 | Cell Cycle | 0.139715 | 0.855 |
| R-HSA-168256 | Immune System | 0.112338 | 0.949 |
| R-HSA-9646399 | Aggrephagy | 0.070911 | 1.149 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.119069 | 0.924 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.058317 | 1.234 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.071282 | 1.147 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.062280 | 1.206 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.174153 | 0.759 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.070997 | 1.149 |
| R-HSA-72766 | Translation | 0.125486 | 0.901 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.169040 | 0.772 |
| R-HSA-4839726 | Chromatin organization | 0.105666 | 0.976 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.137673 | 0.861 |
| R-HSA-8876725 | Protein methylation | 0.161306 | 0.792 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.055902 | 1.253 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.070911 | 1.149 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.166409 | 0.779 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.081591 | 1.088 |
| R-HSA-5688426 | Deubiquitination | 0.113127 | 0.946 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.134456 | 0.871 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.161306 | 0.792 |
| R-HSA-9678110 | Attachment and Entry | 0.169040 | 0.772 |
| R-HSA-9766229 | Degradation of CDH1 | 0.098368 | 1.007 |
| R-HSA-9833482 | PKR-mediated signaling | 0.196157 | 0.707 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.143253 | 0.844 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.151886 | 0.818 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.074542 | 1.128 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.087055 | 1.060 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.087055 | 1.060 |
| R-HSA-162582 | Signal Transduction | 0.096565 | 1.015 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.194926 | 0.710 |
| R-HSA-168249 | Innate Immune System | 0.074684 | 1.127 |
| R-HSA-449147 | Signaling by Interleukins | 0.078168 | 1.107 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.110067 | 0.958 |
| R-HSA-202403 | TCR signaling | 0.104778 | 0.980 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.055997 | 1.252 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.178714 | 0.748 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.178714 | 0.748 |
| R-HSA-9664407 | Parasite infection | 0.178714 | 0.748 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.191819 | 0.717 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.137585 | 0.861 |
| R-HSA-422475 | Axon guidance | 0.155660 | 0.808 |
| R-HSA-69541 | Stabilization of p53 | 0.068326 | 1.165 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.151555 | 0.819 |
| R-HSA-9675108 | Nervous system development | 0.196976 | 0.706 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.050494 | 1.297 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.126516 | 0.898 |
| R-HSA-421270 | Cell-cell junction organization | 0.041107 | 1.386 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.140731 | 0.852 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.179537 | 0.746 |
| R-HSA-1483166 | Synthesis of PA | 0.122109 | 0.913 |
| R-HSA-351202 | Metabolism of polyamines | 0.131343 | 0.882 |
| R-HSA-418990 | Adherens junctions interactions | 0.071282 | 1.147 |
| R-HSA-8848021 | Signaling by PTK6 | 0.140731 | 0.852 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.140731 | 0.852 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.166409 | 0.779 |
| R-HSA-9824272 | Somitogenesis | 0.087055 | 1.060 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.169675 | 0.770 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.163154 | 0.787 |
| R-HSA-162906 | HIV Infection | 0.196580 | 0.706 |
| R-HSA-373755 | Semaphorin interactions | 0.140731 | 0.852 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.098368 | 1.007 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.098368 | 1.007 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.163154 | 0.787 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.103808 | 0.984 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.103808 | 0.984 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.138355 | 0.859 |
| R-HSA-9830369 | Kidney development | 0.153463 | 0.814 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.169675 | 0.770 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.128923 | 0.890 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.194703 | 0.711 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.134456 | 0.871 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.073601 | 1.133 |
| R-HSA-2028269 | Signaling by Hippo | 0.184296 | 0.734 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.120834 | 0.918 |
| R-HSA-5357801 | Programmed Cell Death | 0.156732 | 0.805 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.068326 | 1.165 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.107108 | 0.970 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.197272 | 0.705 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.199274 | 0.701 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.199274 | 0.701 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.199274 | 0.701 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.199274 | 0.701 |
| R-HSA-449836 | Other interleukin signaling | 0.199274 | 0.701 |
| R-HSA-1237112 | Methionine salvage pathway | 0.199274 | 0.701 |
| R-HSA-69242 | S Phase | 0.199624 | 0.700 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.204350 | 0.690 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.206660 | 0.685 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.206660 | 0.685 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.206660 | 0.685 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.206660 | 0.685 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.206723 | 0.685 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.209102 | 0.680 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.209102 | 0.680 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.209869 | 0.678 |
| R-HSA-69306 | DNA Replication | 0.211487 | 0.675 |
| R-HSA-73887 | Death Receptor Signaling | 0.213878 | 0.670 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.213878 | 0.670 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.213978 | 0.670 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.213978 | 0.670 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.213978 | 0.670 |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 0.213978 | 0.670 |
| R-HSA-9612973 | Autophagy | 0.218678 | 0.660 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.221230 | 0.655 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.221230 | 0.655 |
| R-HSA-9694614 | Attachment and Entry | 0.221230 | 0.655 |
| R-HSA-157118 | Signaling by NOTCH | 0.221461 | 0.655 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.223501 | 0.651 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.226501 | 0.645 |
| R-HSA-9663891 | Selective autophagy | 0.226501 | 0.645 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.228414 | 0.641 |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | 0.228414 | 0.641 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.228414 | 0.641 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.228414 | 0.641 |
| R-HSA-109581 | Apoptosis | 0.233208 | 0.632 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.233296 | 0.632 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.235194 | 0.629 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.235533 | 0.628 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.235533 | 0.628 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.235533 | 0.628 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.235533 | 0.628 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.236698 | 0.626 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.238091 | 0.623 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.242587 | 0.615 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.242587 | 0.615 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.242587 | 0.615 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.243510 | 0.613 |
| R-HSA-420029 | Tight junction interactions | 0.249576 | 0.603 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.249576 | 0.603 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.256501 | 0.591 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.256501 | 0.591 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.256501 | 0.591 |
| R-HSA-70635 | Urea cycle | 0.256501 | 0.591 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.257788 | 0.589 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.260572 | 0.584 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.262749 | 0.580 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.262749 | 0.580 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.262749 | 0.580 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.263363 | 0.579 |
| R-HSA-8949613 | Cristae formation | 0.263363 | 0.579 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.263363 | 0.579 |
| R-HSA-157579 | Telomere Maintenance | 0.263988 | 0.578 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.263988 | 0.578 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.267403 | 0.573 |
| R-HSA-77387 | Insulin receptor recycling | 0.270162 | 0.568 |
| R-HSA-622312 | Inflammasomes | 0.270162 | 0.568 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.270162 | 0.568 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.270818 | 0.567 |
| R-HSA-70171 | Glycolysis | 0.274234 | 0.562 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.274234 | 0.562 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.276898 | 0.558 |
| R-HSA-5334118 | DNA methylation | 0.276898 | 0.558 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.276898 | 0.558 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.276898 | 0.558 |
| R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 0.276898 | 0.558 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.283573 | 0.547 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.283573 | 0.547 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.283573 | 0.547 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.283573 | 0.547 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.283573 | 0.547 |
| R-HSA-9679506 | SARS-CoV Infections | 0.285518 | 0.544 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.287885 | 0.541 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.290186 | 0.537 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.290186 | 0.537 |
| R-HSA-186763 | Downstream signal transduction | 0.290186 | 0.537 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.296739 | 0.528 |
| R-HSA-69190 | DNA strand elongation | 0.296739 | 0.528 |
| R-HSA-211000 | Gene Silencing by RNA | 0.301509 | 0.521 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.301550 | 0.521 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.303232 | 0.518 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.303232 | 0.518 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.303232 | 0.518 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.303232 | 0.518 |
| R-HSA-9733709 | Cardiogenesis | 0.303232 | 0.518 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.303232 | 0.518 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.303232 | 0.518 |
| R-HSA-354192 | Integrin signaling | 0.303232 | 0.518 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.309665 | 0.509 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.309665 | 0.509 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.310344 | 0.508 |
| R-HSA-68877 | Mitotic Prometaphase | 0.312864 | 0.505 |
| R-HSA-5673000 | RAF activation | 0.316039 | 0.500 |
| R-HSA-203615 | eNOS activation | 0.316039 | 0.500 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.316039 | 0.500 |
| R-HSA-68886 | M Phase | 0.317693 | 0.498 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.322354 | 0.492 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.325239 | 0.488 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.328612 | 0.483 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.328612 | 0.483 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.328612 | 0.483 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.328614 | 0.483 |
| R-HSA-109582 | Hemostasis | 0.328997 | 0.483 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.334813 | 0.475 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.334813 | 0.475 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.334813 | 0.475 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.335349 | 0.475 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.335554 | 0.474 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.338075 | 0.471 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.340956 | 0.467 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.340956 | 0.467 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.340956 | 0.467 |
| R-HSA-70326 | Glucose metabolism | 0.342065 | 0.466 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.347043 | 0.460 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.347043 | 0.460 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.347043 | 0.460 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.347043 | 0.460 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.353074 | 0.452 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.353074 | 0.452 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.353074 | 0.452 |
| R-HSA-5260271 | Diseases of Immune System | 0.353074 | 0.452 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.353074 | 0.452 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.353074 | 0.452 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.353074 | 0.452 |
| R-HSA-73886 | Chromosome Maintenance | 0.355433 | 0.449 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.355433 | 0.449 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.359050 | 0.445 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.359050 | 0.445 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.359050 | 0.445 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.359050 | 0.445 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.359050 | 0.445 |
| R-HSA-397014 | Muscle contraction | 0.363240 | 0.440 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.364971 | 0.438 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.364971 | 0.438 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.364971 | 0.438 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.364971 | 0.438 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.365751 | 0.437 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.370838 | 0.431 |
| R-HSA-165159 | MTOR signalling | 0.370838 | 0.431 |
| R-HSA-68882 | Mitotic Anaphase | 0.373271 | 0.428 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.375775 | 0.425 |
| R-HSA-9710421 | Defective pyroptosis | 0.376651 | 0.424 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.376651 | 0.424 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.382410 | 0.417 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.382410 | 0.417 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.382410 | 0.417 |
| R-HSA-212436 | Generic Transcription Pathway | 0.383934 | 0.416 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.388117 | 0.411 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.388117 | 0.411 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.388117 | 0.411 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.393771 | 0.405 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.393771 | 0.405 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.393771 | 0.405 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.393771 | 0.405 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.393771 | 0.405 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.393771 | 0.405 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.393771 | 0.405 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.393771 | 0.405 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.394532 | 0.404 |
| R-HSA-8953854 | Metabolism of RNA | 0.396016 | 0.402 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.398163 | 0.400 |
| R-HSA-9909396 | Circadian clock | 0.398163 | 0.400 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.399374 | 0.399 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.399374 | 0.399 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.404925 | 0.393 |
| R-HSA-70263 | Gluconeogenesis | 0.404925 | 0.393 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.404925 | 0.393 |
| R-HSA-73893 | DNA Damage Bypass | 0.410425 | 0.387 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.410425 | 0.387 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.414256 | 0.383 |
| R-HSA-109704 | PI3K Cascade | 0.415874 | 0.381 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.417450 | 0.379 |
| R-HSA-6807070 | PTEN Regulation | 0.423810 | 0.373 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.423810 | 0.373 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.426624 | 0.370 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.430136 | 0.366 |
| R-HSA-1632852 | Macroautophagy | 0.430136 | 0.366 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.431924 | 0.365 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.431924 | 0.365 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.442380 | 0.354 |
| R-HSA-418597 | G alpha (z) signalling events | 0.442380 | 0.354 |
| R-HSA-75893 | TNF signaling | 0.447536 | 0.349 |
| R-HSA-177929 | Signaling by EGFR | 0.447536 | 0.349 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.447536 | 0.349 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.452645 | 0.344 |
| R-HSA-112399 | IRS-mediated signalling | 0.452645 | 0.344 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.457707 | 0.339 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.461199 | 0.336 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.462722 | 0.335 |
| R-HSA-191859 | snRNP Assembly | 0.462722 | 0.335 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.462722 | 0.335 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.467691 | 0.330 |
| R-HSA-983189 | Kinesins | 0.467691 | 0.330 |
| R-HSA-379724 | tRNA Aminoacylation | 0.467691 | 0.330 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.472615 | 0.325 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.472615 | 0.325 |
| R-HSA-450294 | MAP kinase activation | 0.472615 | 0.325 |
| R-HSA-211976 | Endogenous sterols | 0.472615 | 0.325 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.476361 | 0.322 |
| R-HSA-186797 | Signaling by PDGF | 0.477493 | 0.321 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.477493 | 0.321 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.477493 | 0.321 |
| R-HSA-74160 | Gene expression (Transcription) | 0.478874 | 0.320 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.482327 | 0.317 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.482327 | 0.317 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.482327 | 0.317 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.487116 | 0.312 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.487116 | 0.312 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.491861 | 0.308 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.491861 | 0.308 |
| R-HSA-2262752 | Cellular responses to stress | 0.495561 | 0.305 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.496562 | 0.304 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.499208 | 0.302 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.501221 | 0.300 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.501221 | 0.300 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.505836 | 0.296 |
| R-HSA-5218859 | Regulated Necrosis | 0.505836 | 0.296 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.514940 | 0.288 |
| R-HSA-448424 | Interleukin-17 signaling | 0.514940 | 0.288 |
| R-HSA-913531 | Interferon Signaling | 0.515732 | 0.288 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.519429 | 0.284 |
| R-HSA-8978934 | Metabolism of cofactors | 0.519429 | 0.284 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.523877 | 0.281 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.523877 | 0.281 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.523877 | 0.281 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.524283 | 0.280 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.525107 | 0.280 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.528284 | 0.277 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.528284 | 0.277 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.532651 | 0.274 |
| R-HSA-8852135 | Protein ubiquitination | 0.536977 | 0.270 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.536977 | 0.270 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.536977 | 0.270 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.537131 | 0.270 |
| R-HSA-168255 | Influenza Infection | 0.548150 | 0.261 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.549720 | 0.260 |
| R-HSA-9659379 | Sensory processing of sound | 0.553889 | 0.257 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.553889 | 0.257 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.558020 | 0.253 |
| R-HSA-6806834 | Signaling by MET | 0.558020 | 0.253 |
| R-HSA-1483257 | Phospholipid metabolism | 0.559506 | 0.252 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.562113 | 0.250 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.562113 | 0.250 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.566169 | 0.247 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.572270 | 0.242 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.574168 | 0.241 |
| R-HSA-5617833 | Cilium Assembly | 0.577503 | 0.238 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.578113 | 0.238 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.580102 | 0.236 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.582021 | 0.235 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.582021 | 0.235 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.585893 | 0.232 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.587829 | 0.231 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.588560 | 0.230 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.593531 | 0.227 |
| R-HSA-597592 | Post-translational protein modification | 0.597433 | 0.224 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.602968 | 0.220 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.610380 | 0.214 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.611317 | 0.214 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.612020 | 0.213 |
| R-HSA-72172 | mRNA Splicing | 0.615263 | 0.211 |
| R-HSA-9824446 | Viral Infection Pathways | 0.624126 | 0.205 |
| R-HSA-5663205 | Infectious disease | 0.627471 | 0.202 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.629673 | 0.201 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.629673 | 0.201 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.633106 | 0.199 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.636508 | 0.196 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.636508 | 0.196 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.636508 | 0.196 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.643219 | 0.192 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.646527 | 0.189 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.649806 | 0.187 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.649806 | 0.187 |
| R-HSA-1483255 | PI Metabolism | 0.649806 | 0.187 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.650619 | 0.187 |
| R-HSA-1643685 | Disease | 0.651594 | 0.186 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.656272 | 0.183 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.662620 | 0.179 |
| R-HSA-418346 | Platelet homeostasis | 0.665750 | 0.177 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.671924 | 0.173 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.674968 | 0.171 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.674968 | 0.171 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.677985 | 0.169 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.677985 | 0.169 |
| R-HSA-72312 | rRNA processing | 0.678776 | 0.168 |
| R-HSA-6803157 | Antimicrobial peptides | 0.680973 | 0.167 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.683934 | 0.165 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.683934 | 0.165 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.683934 | 0.165 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.686868 | 0.163 |
| R-HSA-15869 | Metabolism of nucleotides | 0.687123 | 0.163 |
| R-HSA-8939211 | ESR-mediated signaling | 0.689182 | 0.162 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.689774 | 0.161 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.695507 | 0.158 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.698334 | 0.156 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.698334 | 0.156 |
| R-HSA-373760 | L1CAM interactions | 0.701135 | 0.154 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.703910 | 0.152 |
| R-HSA-5693538 | Homology Directed Repair | 0.706659 | 0.151 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.709383 | 0.149 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.709383 | 0.149 |
| R-HSA-68875 | Mitotic Prophase | 0.712082 | 0.147 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.714756 | 0.146 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.717406 | 0.144 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.717406 | 0.144 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.720031 | 0.143 |
| R-HSA-977606 | Regulation of Complement cascade | 0.725208 | 0.140 |
| R-HSA-194138 | Signaling by VEGF | 0.727761 | 0.138 |
| R-HSA-199991 | Membrane Trafficking | 0.745418 | 0.128 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.764430 | 0.117 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.774148 | 0.111 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.776249 | 0.110 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.776249 | 0.110 |
| R-HSA-166658 | Complement cascade | 0.780393 | 0.108 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.786466 | 0.104 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.790422 | 0.102 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.794305 | 0.100 |
| R-HSA-2142753 | Arachidonate metabolism | 0.794305 | 0.100 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.796220 | 0.099 |
| R-HSA-9610379 | HCMV Late Events | 0.803703 | 0.095 |
| R-HSA-162587 | HIV Life Cycle | 0.803703 | 0.095 |
| R-HSA-877300 | Interferon gamma signaling | 0.807342 | 0.093 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.809136 | 0.092 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.809136 | 0.092 |
| R-HSA-392499 | Metabolism of proteins | 0.818052 | 0.087 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.821238 | 0.086 |
| R-HSA-5619102 | SLC transporter disorders | 0.821238 | 0.086 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.827809 | 0.082 |
| R-HSA-72306 | tRNA processing | 0.827809 | 0.082 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.828439 | 0.082 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.835685 | 0.078 |
| R-HSA-1474244 | Extracellular matrix organization | 0.838040 | 0.077 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.846282 | 0.072 |
| R-HSA-9609690 | HCMV Early Events | 0.865041 | 0.063 |
| R-HSA-73894 | DNA Repair | 0.868923 | 0.061 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.871791 | 0.060 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.895918 | 0.048 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.909026 | 0.041 |
| R-HSA-9609646 | HCMV Infection | 0.919498 | 0.036 |
| R-HSA-416476 | G alpha (q) signalling events | 0.929439 | 0.032 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.936649 | 0.028 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.941390 | 0.026 |
| R-HSA-8957322 | Metabolism of steroids | 0.959945 | 0.018 |
| R-HSA-211859 | Biological oxidations | 0.962913 | 0.016 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.972572 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 0.981936 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 0.981936 | 0.008 |
| R-HSA-5668914 | Diseases of metabolism | 0.985065 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.995862 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.998718 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.999471 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999556 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999765 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999784 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999926 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999991 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.212 | 2 | 0.856 |
CAMK2G |
0.861 | 0.191 | 2 | 0.886 |
CDC7 |
0.860 | 0.117 | 1 | 0.839 |
NDR2 |
0.857 | 0.138 | -3 | 0.832 |
PIM3 |
0.856 | 0.121 | -3 | 0.829 |
MOS |
0.854 | 0.088 | 1 | 0.843 |
CAMK1B |
0.854 | 0.086 | -3 | 0.847 |
LATS2 |
0.854 | 0.142 | -5 | 0.697 |
TBK1 |
0.853 | 0.001 | 1 | 0.726 |
PRPK |
0.853 | -0.079 | -1 | 0.831 |
MARK4 |
0.852 | 0.093 | 4 | 0.808 |
GCN2 |
0.851 | -0.070 | 2 | 0.800 |
CLK3 |
0.851 | 0.162 | 1 | 0.763 |
IKKB |
0.850 | -0.030 | -2 | 0.783 |
TGFBR2 |
0.850 | 0.112 | -2 | 0.883 |
RAF1 |
0.850 | -0.046 | 1 | 0.808 |
DSTYK |
0.850 | 0.025 | 2 | 0.818 |
BMPR2 |
0.850 | 0.008 | -2 | 0.927 |
PKN3 |
0.850 | 0.045 | -3 | 0.824 |
PRKD1 |
0.849 | 0.115 | -3 | 0.802 |
CAMK2B |
0.849 | 0.205 | 2 | 0.857 |
CAMK2D |
0.849 | 0.111 | -3 | 0.824 |
IKKE |
0.849 | -0.031 | 1 | 0.725 |
PIM1 |
0.848 | 0.136 | -3 | 0.755 |
PDHK4 |
0.848 | -0.182 | 1 | 0.797 |
TSSK2 |
0.847 | 0.113 | -5 | 0.801 |
HUNK |
0.847 | 0.020 | 2 | 0.794 |
TSSK1 |
0.847 | 0.130 | -3 | 0.847 |
ULK2 |
0.846 | -0.105 | 2 | 0.776 |
NLK |
0.846 | -0.017 | 1 | 0.766 |
NDR1 |
0.846 | 0.047 | -3 | 0.811 |
PDHK1 |
0.846 | -0.138 | 1 | 0.780 |
WNK1 |
0.845 | 0.012 | -2 | 0.865 |
AMPKA1 |
0.845 | 0.063 | -3 | 0.829 |
IKKA |
0.844 | 0.065 | -2 | 0.763 |
RSK2 |
0.844 | 0.078 | -3 | 0.742 |
GRK1 |
0.844 | 0.130 | -2 | 0.776 |
TGFBR1 |
0.844 | 0.225 | -2 | 0.876 |
NIK |
0.844 | -0.017 | -3 | 0.869 |
NUAK2 |
0.844 | 0.024 | -3 | 0.820 |
ALK4 |
0.843 | 0.198 | -2 | 0.899 |
ATR |
0.843 | -0.049 | 1 | 0.760 |
GRK6 |
0.843 | 0.087 | 1 | 0.797 |
MTOR |
0.843 | -0.149 | 1 | 0.742 |
NEK6 |
0.843 | -0.002 | -2 | 0.905 |
BMPR1B |
0.842 | 0.254 | 1 | 0.784 |
P90RSK |
0.842 | 0.049 | -3 | 0.752 |
SKMLCK |
0.842 | 0.060 | -2 | 0.841 |
CDKL1 |
0.842 | -0.004 | -3 | 0.793 |
NEK7 |
0.842 | -0.077 | -3 | 0.841 |
PLK3 |
0.841 | 0.170 | 2 | 0.829 |
GRK5 |
0.841 | -0.042 | -3 | 0.888 |
CAMK2A |
0.841 | 0.152 | 2 | 0.857 |
DAPK2 |
0.840 | 0.011 | -3 | 0.858 |
WNK3 |
0.840 | -0.127 | 1 | 0.765 |
ULK1 |
0.840 | -0.079 | -3 | 0.825 |
CAMLCK |
0.840 | -0.006 | -2 | 0.860 |
LATS1 |
0.840 | 0.160 | -3 | 0.847 |
PLK1 |
0.840 | 0.126 | -2 | 0.890 |
ERK5 |
0.840 | -0.046 | 1 | 0.701 |
PRKD2 |
0.839 | 0.071 | -3 | 0.725 |
CHK1 |
0.839 | 0.124 | -3 | 0.807 |
RIPK3 |
0.839 | -0.077 | 3 | 0.750 |
PKCD |
0.838 | 0.024 | 2 | 0.773 |
SRPK1 |
0.838 | 0.069 | -3 | 0.734 |
ALK2 |
0.838 | 0.228 | -2 | 0.878 |
ACVR2A |
0.838 | 0.201 | -2 | 0.882 |
MASTL |
0.837 | -0.158 | -2 | 0.860 |
MAPKAPK2 |
0.837 | 0.087 | -3 | 0.695 |
MARK2 |
0.837 | 0.088 | 4 | 0.749 |
AMPKA2 |
0.837 | 0.038 | -3 | 0.789 |
PKN2 |
0.836 | -0.018 | -3 | 0.814 |
MST4 |
0.836 | -0.019 | 2 | 0.807 |
FAM20C |
0.836 | 0.065 | 2 | 0.604 |
ANKRD3 |
0.836 | -0.054 | 1 | 0.794 |
MARK3 |
0.836 | 0.098 | 4 | 0.769 |
QSK |
0.836 | 0.071 | 4 | 0.793 |
BCKDK |
0.836 | -0.129 | -1 | 0.764 |
ICK |
0.836 | 0.015 | -3 | 0.828 |
ACVR2B |
0.836 | 0.198 | -2 | 0.884 |
RSK3 |
0.836 | 0.011 | -3 | 0.750 |
ATM |
0.836 | 0.013 | 1 | 0.717 |
NUAK1 |
0.835 | 0.026 | -3 | 0.763 |
BRSK1 |
0.835 | 0.059 | -3 | 0.771 |
PAK1 |
0.834 | 0.052 | -2 | 0.785 |
MAPKAPK3 |
0.834 | -0.005 | -3 | 0.745 |
MLK1 |
0.834 | -0.136 | 2 | 0.767 |
CDKL5 |
0.834 | -0.018 | -3 | 0.780 |
TTBK2 |
0.834 | -0.049 | 2 | 0.772 |
CDK8 |
0.834 | 0.017 | 1 | 0.609 |
GRK4 |
0.833 | -0.035 | -2 | 0.832 |
NIM1 |
0.833 | -0.057 | 3 | 0.783 |
CAMK4 |
0.832 | -0.038 | -3 | 0.799 |
P70S6KB |
0.832 | -0.003 | -3 | 0.770 |
PKACG |
0.832 | 0.009 | -2 | 0.737 |
DLK |
0.832 | -0.111 | 1 | 0.765 |
PKR |
0.832 | 0.005 | 1 | 0.756 |
QIK |
0.831 | -0.032 | -3 | 0.827 |
MELK |
0.831 | 0.007 | -3 | 0.769 |
IRE2 |
0.830 | -0.040 | 2 | 0.743 |
IRE1 |
0.830 | -0.098 | 1 | 0.697 |
NEK9 |
0.830 | -0.161 | 2 | 0.791 |
CHAK2 |
0.830 | -0.069 | -1 | 0.889 |
PAK3 |
0.830 | -0.021 | -2 | 0.796 |
SRPK2 |
0.830 | 0.063 | -3 | 0.655 |
SIK |
0.830 | 0.028 | -3 | 0.741 |
KIS |
0.830 | 0.028 | 1 | 0.634 |
AURC |
0.830 | 0.056 | -2 | 0.640 |
MEK1 |
0.830 | -0.065 | 2 | 0.796 |
BMPR1A |
0.830 | 0.243 | 1 | 0.776 |
MARK1 |
0.830 | 0.058 | 4 | 0.784 |
HIPK4 |
0.829 | -0.026 | 1 | 0.693 |
BRSK2 |
0.829 | -0.001 | -3 | 0.788 |
RSK4 |
0.829 | 0.082 | -3 | 0.719 |
PRKD3 |
0.829 | 0.021 | -3 | 0.717 |
MSK2 |
0.828 | -0.007 | -3 | 0.730 |
TLK2 |
0.827 | 0.033 | 1 | 0.756 |
MNK2 |
0.827 | 0.002 | -2 | 0.789 |
DCAMKL1 |
0.827 | 0.065 | -3 | 0.749 |
MLK3 |
0.826 | -0.058 | 2 | 0.716 |
DNAPK |
0.826 | 0.011 | 1 | 0.691 |
RIPK1 |
0.826 | -0.196 | 1 | 0.730 |
PLK4 |
0.826 | -0.018 | 2 | 0.672 |
MLK2 |
0.826 | -0.172 | 2 | 0.761 |
SSTK |
0.826 | 0.069 | 4 | 0.779 |
MSK1 |
0.826 | 0.038 | -3 | 0.733 |
CAMK1G |
0.825 | 0.040 | -3 | 0.735 |
SRPK3 |
0.825 | 0.031 | -3 | 0.720 |
DCAMKL2 |
0.825 | 0.089 | -3 | 0.771 |
CDK19 |
0.825 | 0.009 | 1 | 0.571 |
CDK5 |
0.825 | 0.035 | 1 | 0.647 |
JNK2 |
0.825 | 0.056 | 1 | 0.576 |
MNK1 |
0.825 | 0.026 | -2 | 0.793 |
YSK4 |
0.825 | -0.104 | 1 | 0.736 |
AURB |
0.825 | 0.027 | -2 | 0.646 |
PAK2 |
0.824 | -0.029 | -2 | 0.780 |
MYLK4 |
0.824 | 0.007 | -2 | 0.769 |
VRK2 |
0.824 | -0.192 | 1 | 0.775 |
JNK3 |
0.824 | 0.040 | 1 | 0.605 |
PIM2 |
0.823 | 0.055 | -3 | 0.718 |
CDK7 |
0.823 | -0.019 | 1 | 0.633 |
PKCG |
0.822 | -0.047 | 2 | 0.722 |
NEK2 |
0.822 | -0.114 | 2 | 0.744 |
MLK4 |
0.821 | -0.077 | 2 | 0.708 |
HRI |
0.821 | -0.088 | -2 | 0.921 |
PERK |
0.821 | -0.064 | -2 | 0.905 |
GRK7 |
0.821 | 0.040 | 1 | 0.724 |
SGK3 |
0.820 | 0.017 | -3 | 0.736 |
BRAF |
0.820 | -0.028 | -4 | 0.827 |
CDK1 |
0.820 | 0.032 | 1 | 0.580 |
DRAK1 |
0.820 | -0.007 | 1 | 0.769 |
P38A |
0.820 | 0.008 | 1 | 0.633 |
CDK13 |
0.820 | -0.010 | 1 | 0.603 |
PKACB |
0.820 | 0.051 | -2 | 0.666 |
CLK4 |
0.820 | 0.026 | -3 | 0.737 |
GRK2 |
0.820 | 0.021 | -2 | 0.707 |
PKCB |
0.820 | -0.039 | 2 | 0.694 |
CDK18 |
0.820 | 0.023 | 1 | 0.552 |
WNK4 |
0.820 | -0.075 | -2 | 0.869 |
PHKG1 |
0.819 | -0.088 | -3 | 0.799 |
PLK2 |
0.819 | 0.176 | -3 | 0.835 |
PKCA |
0.819 | -0.053 | 2 | 0.695 |
TLK1 |
0.818 | -0.015 | -2 | 0.871 |
CK2A2 |
0.818 | 0.168 | 1 | 0.737 |
AURA |
0.818 | 0.012 | -2 | 0.615 |
CAMK1D |
0.818 | 0.061 | -3 | 0.653 |
DYRK2 |
0.817 | -0.015 | 1 | 0.599 |
CDK17 |
0.817 | 0.018 | 1 | 0.508 |
MEKK1 |
0.817 | -0.129 | 1 | 0.755 |
PASK |
0.817 | 0.079 | -3 | 0.857 |
P38G |
0.816 | 0.029 | 1 | 0.497 |
PKCH |
0.816 | -0.078 | 2 | 0.691 |
P38B |
0.815 | 0.019 | 1 | 0.559 |
PKCZ |
0.815 | -0.091 | 2 | 0.730 |
TTBK1 |
0.815 | -0.022 | 2 | 0.738 |
SMG1 |
0.815 | -0.128 | 1 | 0.705 |
ERK2 |
0.815 | -0.015 | 1 | 0.595 |
CLK1 |
0.815 | 0.022 | -3 | 0.707 |
PRKX |
0.814 | 0.083 | -3 | 0.645 |
PKG2 |
0.814 | -0.016 | -2 | 0.660 |
SNRK |
0.814 | -0.183 | 2 | 0.668 |
ERK1 |
0.814 | 0.004 | 1 | 0.558 |
CLK2 |
0.814 | 0.095 | -3 | 0.723 |
ZAK |
0.813 | -0.143 | 1 | 0.715 |
CDK2 |
0.813 | -0.032 | 1 | 0.653 |
NEK5 |
0.813 | -0.100 | 1 | 0.762 |
PINK1 |
0.813 | -0.151 | 1 | 0.763 |
DYRK1A |
0.813 | 0.005 | 1 | 0.674 |
AKT2 |
0.813 | -0.002 | -3 | 0.658 |
MEKK3 |
0.813 | -0.159 | 1 | 0.743 |
PAK6 |
0.813 | -0.045 | -2 | 0.726 |
CDK12 |
0.812 | -0.015 | 1 | 0.576 |
SMMLCK |
0.812 | -0.028 | -3 | 0.802 |
MPSK1 |
0.812 | 0.010 | 1 | 0.721 |
MEKK2 |
0.812 | -0.128 | 2 | 0.768 |
MEK5 |
0.812 | -0.257 | 2 | 0.776 |
CHAK1 |
0.812 | -0.191 | 2 | 0.690 |
CDK9 |
0.812 | -0.032 | 1 | 0.603 |
CK1E |
0.811 | -0.003 | -3 | 0.586 |
PHKG2 |
0.811 | -0.071 | -3 | 0.763 |
PRP4 |
0.810 | -0.046 | -3 | 0.730 |
IRAK4 |
0.810 | -0.142 | 1 | 0.697 |
MAPKAPK5 |
0.810 | -0.112 | -3 | 0.700 |
CDK14 |
0.810 | 0.008 | 1 | 0.597 |
CDK16 |
0.809 | 0.038 | 1 | 0.524 |
P38D |
0.809 | 0.035 | 1 | 0.525 |
HIPK1 |
0.809 | 0.010 | 1 | 0.614 |
CDK3 |
0.809 | 0.034 | 1 | 0.527 |
GAK |
0.809 | 0.022 | 1 | 0.782 |
DAPK3 |
0.808 | 0.033 | -3 | 0.775 |
HIPK3 |
0.807 | -0.025 | 1 | 0.634 |
GRK3 |
0.806 | 0.013 | -2 | 0.654 |
CAMKK1 |
0.806 | -0.124 | -2 | 0.793 |
P70S6K |
0.806 | -0.040 | -3 | 0.681 |
HIPK2 |
0.806 | 0.018 | 1 | 0.530 |
CK2A1 |
0.806 | 0.126 | 1 | 0.718 |
AKT1 |
0.805 | -0.002 | -3 | 0.671 |
TAO3 |
0.805 | -0.108 | 1 | 0.749 |
PKCT |
0.805 | -0.084 | 2 | 0.702 |
MST3 |
0.805 | -0.098 | 2 | 0.758 |
DYRK4 |
0.805 | 0.014 | 1 | 0.549 |
NEK8 |
0.804 | -0.159 | 2 | 0.769 |
IRAK1 |
0.804 | -0.234 | -1 | 0.762 |
CK1D |
0.804 | -0.002 | -3 | 0.537 |
CK1G1 |
0.804 | -0.032 | -3 | 0.586 |
CAMK1A |
0.803 | 0.033 | -3 | 0.612 |
PKACA |
0.803 | 0.015 | -2 | 0.609 |
LKB1 |
0.803 | -0.107 | -3 | 0.828 |
CAMKK2 |
0.803 | -0.117 | -2 | 0.784 |
DYRK1B |
0.803 | -0.001 | 1 | 0.590 |
TAO2 |
0.803 | -0.134 | 2 | 0.800 |
PKCI |
0.803 | -0.069 | 2 | 0.707 |
MST2 |
0.803 | -0.068 | 1 | 0.774 |
PDK1 |
0.802 | -0.105 | 1 | 0.761 |
DAPK1 |
0.802 | 0.022 | -3 | 0.762 |
GCK |
0.802 | -0.035 | 1 | 0.786 |
CDK10 |
0.801 | 0.016 | 1 | 0.586 |
TAK1 |
0.801 | -0.077 | 1 | 0.811 |
NEK11 |
0.801 | -0.206 | 1 | 0.771 |
JNK1 |
0.800 | 0.018 | 1 | 0.566 |
MRCKA |
0.800 | 0.042 | -3 | 0.720 |
EEF2K |
0.800 | -0.046 | 3 | 0.832 |
PKN1 |
0.799 | -0.036 | -3 | 0.691 |
TNIK |
0.799 | -0.046 | 3 | 0.836 |
STK33 |
0.799 | -0.016 | 2 | 0.727 |
CK1A2 |
0.798 | -0.014 | -3 | 0.533 |
HGK |
0.798 | -0.091 | 3 | 0.839 |
ROCK2 |
0.798 | 0.038 | -3 | 0.758 |
NEK4 |
0.797 | -0.177 | 1 | 0.732 |
MINK |
0.797 | -0.097 | 1 | 0.748 |
MRCKB |
0.797 | 0.014 | -3 | 0.707 |
DYRK3 |
0.797 | -0.025 | 1 | 0.610 |
GSK3B |
0.797 | -0.106 | 4 | 0.314 |
MST1 |
0.797 | -0.052 | 1 | 0.747 |
CDK6 |
0.797 | -0.004 | 1 | 0.582 |
MEK2 |
0.796 | -0.160 | 2 | 0.761 |
GSK3A |
0.796 | -0.065 | 4 | 0.328 |
LRRK2 |
0.796 | -0.168 | 2 | 0.798 |
PKCE |
0.796 | -0.041 | 2 | 0.693 |
ERK7 |
0.796 | -0.045 | 2 | 0.502 |
PBK |
0.795 | -0.007 | 1 | 0.725 |
NEK1 |
0.795 | -0.130 | 1 | 0.729 |
PAK5 |
0.795 | -0.075 | -2 | 0.663 |
SGK1 |
0.795 | 0.017 | -3 | 0.576 |
MEKK6 |
0.794 | -0.195 | 1 | 0.734 |
CDK4 |
0.794 | -0.009 | 1 | 0.560 |
LOK |
0.794 | -0.094 | -2 | 0.807 |
MAP3K15 |
0.794 | -0.183 | 1 | 0.712 |
AKT3 |
0.793 | 0.006 | -3 | 0.589 |
SBK |
0.792 | 0.015 | -3 | 0.523 |
HPK1 |
0.792 | -0.085 | 1 | 0.763 |
KHS1 |
0.792 | -0.040 | 1 | 0.744 |
PDHK3_TYR |
0.792 | 0.234 | 4 | 0.823 |
MAK |
0.792 | 0.049 | -2 | 0.709 |
PAK4 |
0.791 | -0.069 | -2 | 0.661 |
CHK2 |
0.791 | -0.034 | -3 | 0.591 |
VRK1 |
0.791 | -0.200 | 2 | 0.798 |
SLK |
0.791 | -0.078 | -2 | 0.748 |
DMPK1 |
0.790 | 0.048 | -3 | 0.715 |
KHS2 |
0.790 | -0.023 | 1 | 0.763 |
YANK3 |
0.790 | 0.092 | 2 | 0.591 |
BIKE |
0.789 | 0.052 | 1 | 0.668 |
TTK |
0.788 | 0.022 | -2 | 0.889 |
RIPK2 |
0.788 | -0.260 | 1 | 0.700 |
YSK1 |
0.788 | -0.137 | 2 | 0.753 |
BUB1 |
0.786 | 0.008 | -5 | 0.752 |
NEK3 |
0.784 | -0.184 | 1 | 0.702 |
CRIK |
0.784 | 0.025 | -3 | 0.670 |
MOK |
0.782 | -0.011 | 1 | 0.599 |
ROCK1 |
0.781 | -0.004 | -3 | 0.715 |
TESK1_TYR |
0.781 | -0.060 | 3 | 0.869 |
EPHA6 |
0.780 | 0.105 | -1 | 0.813 |
ALPHAK3 |
0.780 | -0.046 | -1 | 0.761 |
PDHK4_TYR |
0.779 | 0.041 | 2 | 0.838 |
MAP2K7_TYR |
0.779 | -0.152 | 2 | 0.825 |
MAP2K6_TYR |
0.778 | -0.002 | -1 | 0.856 |
PDHK1_TYR |
0.778 | 0.006 | -1 | 0.870 |
OSR1 |
0.777 | -0.110 | 2 | 0.755 |
PKMYT1_TYR |
0.777 | -0.108 | 3 | 0.834 |
MAP2K4_TYR |
0.777 | -0.109 | -1 | 0.847 |
ASK1 |
0.777 | -0.160 | 1 | 0.701 |
PKG1 |
0.776 | -0.066 | -2 | 0.582 |
BMPR2_TYR |
0.776 | -0.002 | -1 | 0.824 |
AAK1 |
0.775 | 0.085 | 1 | 0.571 |
PINK1_TYR |
0.774 | -0.173 | 1 | 0.767 |
EPHA4 |
0.773 | 0.139 | 2 | 0.823 |
TYK2 |
0.773 | -0.119 | 1 | 0.734 |
RET |
0.772 | -0.104 | 1 | 0.724 |
HASPIN |
0.772 | -0.068 | -1 | 0.731 |
EPHB4 |
0.772 | 0.040 | -1 | 0.781 |
MYO3A |
0.771 | -0.138 | 1 | 0.724 |
LIMK2_TYR |
0.770 | -0.113 | -3 | 0.869 |
TYRO3 |
0.770 | -0.099 | 3 | 0.795 |
MYO3B |
0.769 | -0.162 | 2 | 0.758 |
MST1R |
0.769 | -0.133 | 3 | 0.811 |
FER |
0.769 | -0.004 | 1 | 0.801 |
JAK2 |
0.769 | -0.123 | 1 | 0.726 |
TAO1 |
0.769 | -0.169 | 1 | 0.690 |
DDR1 |
0.769 | -0.104 | 4 | 0.757 |
SRMS |
0.768 | 0.064 | 1 | 0.788 |
ROS1 |
0.768 | -0.108 | 3 | 0.771 |
INSRR |
0.767 | 0.019 | 3 | 0.761 |
LIMK1_TYR |
0.767 | -0.233 | 2 | 0.811 |
TXK |
0.765 | 0.086 | 1 | 0.792 |
FGFR2 |
0.765 | -0.036 | 3 | 0.802 |
EPHB1 |
0.765 | 0.027 | 1 | 0.781 |
YES1 |
0.765 | -0.030 | -1 | 0.825 |
CSF1R |
0.765 | -0.098 | 3 | 0.788 |
TNK2 |
0.764 | -0.025 | 3 | 0.767 |
FGR |
0.764 | -0.058 | 1 | 0.764 |
EPHB2 |
0.764 | 0.056 | -1 | 0.756 |
PDGFRB |
0.764 | -0.088 | 3 | 0.813 |
CK1A |
0.764 | -0.009 | -3 | 0.448 |
STLK3 |
0.763 | -0.199 | 1 | 0.689 |
EPHB3 |
0.763 | 0.016 | -1 | 0.763 |
HCK |
0.763 | -0.061 | -1 | 0.787 |
JAK3 |
0.762 | -0.126 | 1 | 0.716 |
FGFR1 |
0.761 | -0.082 | 3 | 0.780 |
ABL2 |
0.760 | -0.084 | -1 | 0.799 |
FLT3 |
0.760 | -0.120 | 3 | 0.790 |
AXL |
0.760 | -0.058 | 3 | 0.784 |
KIT |
0.759 | -0.092 | 3 | 0.793 |
EPHA7 |
0.759 | 0.057 | 2 | 0.823 |
LCK |
0.759 | -0.042 | -1 | 0.790 |
BLK |
0.758 | 0.008 | -1 | 0.797 |
TEK |
0.758 | -0.116 | 3 | 0.735 |
NEK10_TYR |
0.758 | -0.132 | 1 | 0.652 |
MERTK |
0.758 | -0.020 | 3 | 0.775 |
ITK |
0.758 | -0.034 | -1 | 0.765 |
EPHA3 |
0.757 | 0.006 | 2 | 0.812 |
KDR |
0.756 | -0.110 | 3 | 0.766 |
YANK2 |
0.756 | 0.048 | 2 | 0.607 |
JAK1 |
0.756 | -0.100 | 1 | 0.699 |
TNNI3K_TYR |
0.756 | -0.121 | 1 | 0.689 |
LTK |
0.756 | -0.071 | 3 | 0.748 |
ALK |
0.756 | -0.084 | 3 | 0.735 |
PTK2B |
0.755 | 0.074 | -1 | 0.743 |
ABL1 |
0.755 | -0.120 | -1 | 0.795 |
NTRK1 |
0.755 | -0.082 | -1 | 0.780 |
FGFR3 |
0.755 | -0.049 | 3 | 0.781 |
TNK1 |
0.755 | -0.131 | 3 | 0.763 |
FRK |
0.754 | -0.047 | -1 | 0.803 |
PDGFRA |
0.754 | -0.192 | 3 | 0.804 |
TEC |
0.754 | -0.055 | -1 | 0.699 |
EPHA5 |
0.753 | 0.054 | 2 | 0.802 |
BTK |
0.753 | -0.165 | -1 | 0.738 |
BMX |
0.753 | -0.045 | -1 | 0.662 |
EPHA1 |
0.752 | -0.078 | 3 | 0.772 |
ERBB2 |
0.752 | -0.117 | 1 | 0.693 |
FYN |
0.751 | -0.004 | -1 | 0.759 |
CK1G3 |
0.751 | -0.018 | -3 | 0.407 |
INSR |
0.751 | -0.090 | 3 | 0.727 |
FLT1 |
0.751 | -0.083 | -1 | 0.815 |
MET |
0.751 | -0.113 | 3 | 0.786 |
PTK2 |
0.750 | 0.117 | -1 | 0.736 |
NTRK2 |
0.750 | -0.147 | 3 | 0.775 |
PTK6 |
0.750 | -0.177 | -1 | 0.724 |
FLT4 |
0.749 | -0.128 | 3 | 0.751 |
LYN |
0.749 | -0.081 | 3 | 0.703 |
EPHA8 |
0.748 | 0.024 | -1 | 0.751 |
EGFR |
0.748 | -0.011 | 1 | 0.597 |
WEE1_TYR |
0.747 | -0.156 | -1 | 0.714 |
FGFR4 |
0.746 | -0.007 | -1 | 0.745 |
DDR2 |
0.746 | -0.051 | 3 | 0.753 |
CSK |
0.746 | -0.038 | 2 | 0.834 |
MATK |
0.746 | -0.073 | -1 | 0.739 |
NTRK3 |
0.745 | -0.103 | -1 | 0.729 |
EPHA2 |
0.742 | 0.035 | -1 | 0.711 |
SRC |
0.742 | -0.069 | -1 | 0.771 |
SYK |
0.739 | 0.023 | -1 | 0.726 |
IGF1R |
0.738 | -0.061 | 3 | 0.666 |
ERBB4 |
0.732 | -0.031 | 1 | 0.618 |
MUSK |
0.731 | -0.164 | 1 | 0.596 |
FES |
0.725 | -0.091 | -1 | 0.654 |
CK1G2 |
0.724 | -0.044 | -3 | 0.503 |
ZAP70 |
0.703 | -0.114 | -1 | 0.640 |