Motif 62 (n=242)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S26 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A0JNW5 | BLTP3B | S414 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A4UGR9 | XIRP2 | S2969 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6H8Y1 | BDP1 | S2451 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NMY6 | ANXA2P2 | S236 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| C9J798 | RASA4B | S760 | ochoa | Ras GTPase-activating protein 4B | Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}. |
| O00327 | BMAL1 | S592 | psp | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O00409 | FOXN3 | S85 | ochoa|psp | Forkhead box protein N3 (Checkpoint suppressor 1) | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. |
| O14983 | ATP2A1 | S499 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15061 | SYNM | S653 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15151 | MDM4 | S314 | psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15350 | TP73 | S145 | ochoa | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O43374 | RASA4 | S760 | ochoa | Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}. |
| O43379 | WDR62 | S501 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43765 | SGTA | S77 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| O60218 | AKR1B10 | S23 | ochoa | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}. |
| O60281 | ZNF292 | S1462 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60502 | OGA | S511 | ochoa | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714, ECO:0000269|PubMed:28939839, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}. |
| O75140 | DEPDC5 | S503 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75312 | ZPR1 | S190 | ochoa | Zinc finger protein ZPR1 (Zinc finger protein 259) | Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}. |
| O75363 | BCAS1 | S63 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75764 | TCEA3 | S164 | ochoa | Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| O75815 | BCAR3 | S182 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75969 | AKAP3 | S636 | ochoa | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}. |
| O76039 | CDKL5 | S306 | ochoa|psp | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O95071 | UBR5 | S1227 | ochoa|psp | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95239 | KIF4A | S1186 | ochoa|psp | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95402 | MED26 | S535 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95994 | AGR2 | S119 | ochoa | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) | Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}. |
| P00352 | ALDH1A1 | S75 | ochoa | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
| P02452 | COL1A1 | S1247 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P05181 | CYP2E1 | S424 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P07355 | ANXA2 | S236 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P11137 | MAP2 | S285 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11137 | MAP2 | S311 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11182 | DBT | S220 | ochoa | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) | The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. {ECO:0000250|UniProtKB:P11181}. |
| P16157 | ANK1 | S903 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P16157 | ANK1 | S1686 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17097 | ZNF7 | S112 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P17980 | PSMC3 | S376 | ochoa | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P18031 | PTPN1 | S386 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P28749 | RBL1 | S615 | ochoa|psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P31152 | MAPK4 | S434 | ochoa | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| P35367 | HRH1 | S275 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P37275 | ZEB1 | S447 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P43354 | NR4A2 | S181 | ochoa|psp | Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}. |
| P46821 | MAP1B | S1076 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46940 | IQGAP1 | S86 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49023 | PXN | S130 | ochoa|psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49756 | RBM25 | S677 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49915 | GMPS | S332 | ochoa | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}. |
| P51587 | BRCA2 | S492 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52888 | THOP1 | S89 | ochoa | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P53367 | ARFIP1 | S79 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P55273 | CDKN2D | S76 | psp | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}. |
| P57060 | RWDD2B | S173 | ochoa | RWD domain-containing protein 2B | None |
| P61764 | STXBP1 | S89 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P61978 | HNRNPK | S116 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78312 | FAM193A | S270 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78362 | SRPK2 | S496 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| P78559 | MAP1A | S1654 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02880 | TOP2B | S1424 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q03001 | DST | S237 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q04206 | RELA | S316 | ochoa|psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q04656 | ATP7A | S270 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04727 | TLE4 | S265 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q05209 | PTPN12 | S19 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05209 | PTPN12 | S332 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07157 | TJP1 | S1399 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12796 | PNRC1 | S289 | ochoa | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | Nuclear receptor coactivator. May play a role in signal transduction. {ECO:0000269|PubMed:10894149}. |
| Q12830 | BPTF | S763 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12888 | TP53BP1 | S630 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12979 | ABR | S53 | ochoa | Active breakpoint cluster region-related protein | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}. |
| Q13342 | SP140 | S467 | ochoa | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}. |
| Q13415 | ORC1 | S287 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13433 | SLC39A6 | S220 | ochoa | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}. |
| Q13873 | BMPR2 | S515 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q13972 | RASGRF1 | S857 | ochoa | Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) | Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}. |
| Q14162 | SCARF1 | S611 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14201 | BTG3 | S169 | ochoa | Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5) | Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. |
| Q14258 | TRIM25 | S187 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14449 | GRB14 | S419 | ochoa|psp | Growth factor receptor-bound protein 14 (GRB14 adapter protein) | Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. |
| Q14678 | KANK1 | S641 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14789 | GOLGB1 | S967 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15116 | PDCD1 | S261 | psp | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005, PubMed:37208329). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). {ECO:0000250|UniProtKB:Q02242, ECO:0000269|PubMed:21276005, ECO:0000269|PubMed:37208329}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552). {ECO:0000269|PubMed:22658127, ECO:0000269|PubMed:25034862, ECO:0000269|PubMed:25399552, ECO:0000303|PubMed:28951311}. |
| Q15149 | PLEC | S720 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15311 | RALBP1 | S48 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15527 | SURF2 | S59 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q16555 | DPYSL2 | S522 | ochoa|psp | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16584 | MAP3K11 | S507 | ochoa | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q2LD37 | BLTP1 | S3196 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4LE39 | ARID4B | S778 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q5T0D9 | TPRG1L | S227 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q5T5C0 | STXBP5 | S902 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T6C5 | ATXN7L2 | S213 | ochoa | Ataxin-7-like protein 2 | None |
| Q5T8P6 | RBM26 | S795 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5TC82 | RC3H1 | S811 | ochoa | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. |
| Q5UIP0 | RIF1 | S1854 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S798 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YH5 | CDCA2 | S470 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6GYQ0 | RALGAPA1 | S1004 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6IMN6 | CAPRIN2 | S566 | ochoa | Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) | Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}. |
| Q6IQ55 | TTBK2 | S422 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NYC8 | PPP1R18 | S195 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P4R8 | NFRKB | S176 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6P995 | FAM171B | S794 | ochoa | Protein FAM171B | None |
| Q6PJW8 | CNST | S436 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6T4R5 | NHS | S739 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6T4R5 | NHS | S993 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6T4R5 | NHS | S1329 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6ZS81 | WDFY4 | S1688 | ochoa | WD repeat- and FYVE domain-containing protein 4 | Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. {ECO:0000250|UniProtKB:E9Q2M9}. |
| Q6ZUM4 | ARHGAP27 | S486 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q6ZVH7 | ESPNL | S635 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
| Q6ZVM7 | TOM1L2 | S160 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q702N8 | XIRP1 | S1669 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q70CQ3 | USP30 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}. |
| Q70E73 | RAPH1 | S1098 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7L1V2 | MON1B | S61 | ochoa | Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein) | None |
| Q7LBC6 | KDM3B | S1253 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z3T8 | ZFYVE16 | S815 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z3T8 | ZFYVE16 | S845 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z3U7 | MON2 | S1177 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q7Z4V5 | HDGFL2 | S490 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z569 | BRAP | S52 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q7Z6E9 | RBBP6 | S1535 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z7G8 | VPS13B | S1800 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86V48 | LUZP1 | S423 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XP3 | DDX42 | S96 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q86Z20 | CCDC125 | S58 | ochoa | Coiled-coil domain-containing protein 125 (Protein kenae) | May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}. |
| Q8IUG5 | MYO18B | S2236 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IX21 | SLF2 | S701 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IZC7 | ZNF101 | S152 | ochoa | Zinc finger protein 101 (Zinc finger protein HZF12) | May be involved in transcriptional regulation. |
| Q8IZT6 | ASPM | S435 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8IZW8 | TNS4 | S169 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N0Z2 | ABRA | S156 | ochoa | Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) | Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000250|UniProtKB:Q8BUZ1}. |
| Q8N157 | AHI1 | S1005 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N5H7 | SH2D3C | S63 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NCG7 | DAGLB | S570 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8NI08 | NCOA7 | S502 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TE68 | EPS8L1 | S239 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TE76 | MORC4 | S545 | ochoa | MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) | Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:26933034}. |
| Q8TEP8 | CEP192 | S995 | psp | Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2) | Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:17980596, PubMed:18207742, PubMed:25042804). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:17980596, PubMed:18207742, PubMed:25042804). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}. |
| Q8WUA4 | GTF3C2 | S167 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WV44 | TRIM41 | S401 | ochoa | E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) | E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). {ECO:0000250|UniProtKB:Q5NCC3, ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016, ECO:0000269|PubMed:33378676}. |
| Q8WVI7 | PPP1R1C | S65 | ochoa | Protein phosphatase 1 regulatory subunit 1C (Inhibitor-5 of protein phosphatase 1) (IPP5) | May increase cell susceptibility to TNF-induced apoptosis. {ECO:0000269|PubMed:19874272}. |
| Q8WWN9 | IPCEF1 | S326 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q8WXG6 | MADD | S921 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WXG6 | MADD | S1059 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WYA1 | BMAL2 | S540 | ochoa | Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. {ECO:0000269|PubMed:11018023, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:14672706}. |
| Q8WYB5 | KAT6B | S1581 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
| Q8WYL5 | SSH1 | S57 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WZ75 | ROBO4 | S684 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92560 | BAP1 | S583 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92585 | MAML1 | S45 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92608 | DOCK2 | S218 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92619 | ARHGAP45 | S25 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92620 | DHX38 | S234 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) | Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}. |
| Q92628 | KIAA0232 | S814 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92747 | ARPC1A | S26 | ochoa | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|PubMed:8978670}. |
| Q96C34 | RUNDC1 | S491 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96EY5 | MVB12A | S80 | ochoa | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96GX5 | MASTL | S453 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96HH9 | GRAMD2B | S72 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96IT1 | ZNF496 | S299 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96K83 | ZNF521 | S546 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96LW4 | PRIMPOL | S499 | ochoa | DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.102) (EC 2.7.7.7) (Coiled-coil domain-containing protein 111) | DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:24682820, PubMed:25255211, PubMed:25262353, PubMed:25550423, PubMed:25746449, PubMed:27989484, PubMed:28534480, PubMed:29608762, PubMed:30889508, PubMed:31676232). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:24682820, PubMed:25255211, PubMed:25262353, PubMed:25550423, PubMed:25746449, PubMed:27989484, PubMed:28534480, PubMed:29608762, PubMed:30633872, PubMed:30889508). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25746449). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:24240614, PubMed:26626482, PubMed:28534480, PubMed:30478192). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Repriming avoids fork degradation while leading to accumulation of internal ssDNA gaps behind the forks (PubMed:24240614, PubMed:25746449, PubMed:31676232). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (PubMed:24207056, PubMed:25255211, PubMed:25746449). Also required for reinitiating stalled forks after UV damage during nuclear DNA replication (PubMed:24240614). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (PubMed:24207056). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH (PubMed:24240614). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (PubMed:30715459). {ECO:0000250|UniProtKB:Q6P1E7, ECO:0000269|PubMed:24126761, ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614, ECO:0000269|PubMed:24267451, ECO:0000269|PubMed:24682820, ECO:0000269|PubMed:25255211, ECO:0000269|PubMed:25262353, ECO:0000269|PubMed:25550423, ECO:0000269|PubMed:25746449, ECO:0000269|PubMed:26626482, ECO:0000269|PubMed:27989484, ECO:0000269|PubMed:28534480, ECO:0000269|PubMed:29608762, ECO:0000269|PubMed:30478192, ECO:0000269|PubMed:30633872, ECO:0000269|PubMed:30715459, ECO:0000269|PubMed:30889508, ECO:0000269|PubMed:31676232}. |
| Q96PE5 | OPALIN | S88 | ochoa | Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10) | Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. {ECO:0000250|UniProtKB:Q7M750}. |
| Q96PK6 | RBM14 | S627 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PY6 | NEK1 | S806 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96QT6 | PHF12 | S131 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96S66 | CLCC1 | S438 | ochoa | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q99959 | PKP2 | S102 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQ65 | USB1 | S36 | ochoa | U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) | 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367). {ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480, ECO:0000269|PubMed:23190533, ECO:0000269|PubMed:26213367, ECO:0000269|PubMed:28887445, ECO:0000269|PubMed:30215753, ECO:0000269|PubMed:31832688}. |
| Q9BT25 | HAUS8 | S385 | ochoa | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTE3 | MCMBP | S154 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BUA3 | SPINDOC | S82 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BW04 | SARG | S502 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX66 | SORBS1 | S350 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BYT3 | STK33 | S470 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9C0D7 | ZC3H12C | S760 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9H0G5 | NSRP1 | S291 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H175 | CSRNP2 | S504 | ochoa | Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. {ECO:0000250}. |
| Q9H1B7 | IRF2BPL | S69 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H1H9 | KIF13A | S636 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H213 | MAGEH1 | S155 | ochoa | Melanoma-associated antigen H1 (Apoptosis-related protein 1) (APR-1) (MAGE-H1 antigen) (Restin) | None |
| Q9H2J7 | SLC6A15 | S701 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H2Y7 | ZNF106 | S641 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4B6 | SAV1 | S27 | ochoa|psp | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H4H8 | FAM83D | S298 | ochoa | Protein FAM83D (Spindle protein CHICA) | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}. |
| Q9H5H4 | ZNF768 | S160 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H6S0 | YTHDC2 | S1223 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9H6U6 | BCAS3 | S869 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H8G2 | CAAP1 | S312 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9H9E1 | ANKRA2 | S106 | ochoa | Ankyrin repeat family A protein 2 (RFXANK-like protein 2) | May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}. |
| Q9HB96 | FANCE | S249 | ochoa | Fanconi anemia group E protein (Protein FACE) | As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. {ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:17296736}. |
| Q9HBT8 | ZNF286A | S19 | ochoa | Zinc finger protein 286A | May be involved in transcriptional regulation. |
| Q9HC35 | EML4 | S73 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HC62 | SENP2 | S123 | ochoa | Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:15296745, PubMed:20194620, PubMed:21965678). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15296745, PubMed:20194620, PubMed:21965678). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:15296745, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:21965678}. |
| Q9HD67 | MYO10 | S1007 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9NRS6 | SNX15 | S201 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NSI6 | BRWD1 | S649 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NTZ6 | RBM12 | S375 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NWL6 | ASNSD1 | S396 | ochoa | Asparagine synthetase domain-containing protein 1 (HCV NS3-transactivated protein 1) | None |
| Q9NYI0 | PSD3 | S380 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NYP3 | DONSON | S34 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NYQ6 | CELSR1 | S2960 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZ56 | FMN2 | S747 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZN5 | ARHGEF12 | S637 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Q0 | VPS54 | S541 | ochoa | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q9P1Y6 | PHRF1 | S973 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P227 | ARHGAP23 | S1412 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2B4 | CTTNBP2NL | S285 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9P2N6 | KANSL3 | S633 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9P2R7 | SUCLA2 | S79 | ochoa|psp | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) | ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282, PubMed:34492704). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282, ECO:0000269|PubMed:34492704}. |
| Q9P2W9 | STX18 | S189 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UHB6 | LIMA1 | S698 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHR4 | BAIAP2L1 | S261 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UIF8 | BAZ2B | S681 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKA4 | AKAP11 | S1242 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKE5 | TNIK | S526 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKL0 | RCOR1 | S460 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKN8 | GTF3C4 | S611 | ochoa | General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) | Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}. |
| Q9UL54 | TAOK2 | S827 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULW0 | TPX2 | S293 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UMD9 | COL17A1 | S174 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UNN5 | FAF1 | S270 | ochoa | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) | Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. |
| Q9UPA5 | BSN | S1477 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPN3 | MACF1 | S280 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN6 | SCAF8 | S617 | ochoa | SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| Q9UPQ0 | LIMCH1 | S169 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y217 | MTMR6 | S589 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}. |
| Q9Y222 | DMTF1 | S701 | ochoa | Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1) | Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. {ECO:0000250, ECO:0000269|PubMed:12917399}. |
| Q9Y2H5 | PLEKHA6 | S506 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2H9 | MAST1 | S163 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I7 | PIKFYVE | S1714 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2W1 | THRAP3 | S682 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4C1 | KDM3A | S283 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| Q9Y4G2 | PLEKHM1 | S501 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y5B0 | CTDP1 | S740 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| P21333 | FLNA | S732 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| Q9NRM7 | LATS2 | Y1051 | Sugiyama | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9UQ07 | MOK | S365 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-446107 | Type I hemidesmosome assembly | 0.000819 | 3.087 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.000587 | 3.231 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.031898 | 1.496 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.031898 | 1.496 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 0.047466 | 1.324 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 0.062783 | 1.202 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 0.062783 | 1.202 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.107280 | 0.969 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 0.107280 | 0.969 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 0.107280 | 0.969 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 0.121639 | 0.915 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.121639 | 0.915 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 0.121639 | 0.915 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 0.121639 | 0.915 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.010016 | 1.999 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 0.135768 | 0.867 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.135768 | 0.867 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.135768 | 0.867 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.135768 | 0.867 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.046213 | 1.335 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.176812 | 0.752 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.203090 | 0.692 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.007563 | 2.121 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.085918 | 1.066 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.215913 | 0.666 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.228532 | 0.641 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.228532 | 0.641 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.228532 | 0.641 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.029328 | 1.533 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.029328 | 1.533 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 0.253164 | 0.597 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.277013 | 0.557 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.043958 | 1.357 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.143429 | 0.843 |
| R-HSA-380287 | Centrosome maturation | 0.047295 | 1.325 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.322460 | 0.492 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.322460 | 0.492 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.074447 | 1.128 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.333369 | 0.477 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.333369 | 0.477 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.333369 | 0.477 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.333369 | 0.477 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.130687 | 0.884 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.354666 | 0.450 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.365059 | 0.438 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.254103 | 0.595 |
| R-HSA-211999 | CYP2E1 reactions | 0.385348 | 0.414 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.395248 | 0.403 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.404990 | 0.393 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.414576 | 0.382 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.414576 | 0.382 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.414576 | 0.382 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.424007 | 0.373 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.424007 | 0.373 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.424007 | 0.373 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.433287 | 0.363 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.485923 | 0.313 |
| R-HSA-72172 | mRNA Splicing | 0.298926 | 0.524 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.442419 | 0.354 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.264899 | 0.577 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.005937 | 2.226 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.344104 | 0.463 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.021366 | 1.670 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 0.322460 | 0.492 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.011040 | 1.957 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.424007 | 0.373 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.485923 | 0.313 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.016584 | 1.780 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.442419 | 0.354 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.485923 | 0.313 |
| R-HSA-191650 | Regulation of gap junction activity | 0.092686 | 1.033 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.107280 | 0.969 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.176812 | 0.752 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.228532 | 0.641 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.240947 | 0.618 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.365059 | 0.438 |
| R-HSA-5689603 | UCH proteinases | 0.156876 | 0.804 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.228532 | 0.641 |
| R-HSA-4641265 | Repression of WNT target genes | 0.228532 | 0.641 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.058540 | 1.233 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.058540 | 1.233 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.058540 | 1.233 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.333369 | 0.477 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.494209 | 0.306 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.033561 | 1.474 |
| R-HSA-9909396 | Circadian clock | 0.094791 | 1.023 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.033561 | 1.474 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.107280 | 0.969 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.236211 | 0.627 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.510385 | 0.292 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.024429 | 1.612 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.477501 | 0.321 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.404990 | 0.393 |
| R-HSA-2028269 | Signaling by Hippo | 0.005747 | 2.241 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.253164 | 0.597 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.242169 | 0.616 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.192642 | 0.715 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.468942 | 0.329 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.251614 | 0.599 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.508043 | 0.294 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.058540 | 1.233 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.288652 | 0.540 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.510385 | 0.292 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.031639 | 1.500 |
| R-HSA-1474290 | Collagen formation | 0.090423 | 1.044 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.062783 | 1.202 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.077856 | 1.109 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.092686 | 1.033 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.121639 | 0.915 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.190057 | 0.721 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.215913 | 0.666 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.240947 | 0.618 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.265185 | 0.576 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.311372 | 0.507 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.365059 | 0.438 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.248133 | 0.605 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.433287 | 0.363 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.433287 | 0.363 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.451403 | 0.345 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.451403 | 0.345 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.477501 | 0.321 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.378005 | 0.423 |
| R-HSA-1538133 | G0 and Early G1 | 0.127016 | 0.896 |
| R-HSA-201451 | Signaling by BMP | 0.100807 | 0.997 |
| R-HSA-69541 | Stabilization of p53 | 0.171663 | 0.765 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.451403 | 0.345 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.404990 | 0.393 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.468942 | 0.329 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.349039 | 0.457 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.383736 | 0.416 |
| R-HSA-68877 | Mitotic Prometaphase | 0.261849 | 0.582 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.497880 | 0.303 |
| R-HSA-447043 | Neurofascin interactions | 0.135768 | 0.867 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.288652 | 0.540 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.300104 | 0.523 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.260075 | 0.585 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.485923 | 0.313 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.038628 | 1.413 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.149671 | 0.825 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.253164 | 0.597 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.365059 | 0.438 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.272023 | 0.565 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.502362 | 0.299 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.385348 | 0.414 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.007689 | 2.114 |
| R-HSA-426048 | Arachidonate production from DAG | 0.190057 | 0.721 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.203090 | 0.692 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.215913 | 0.666 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.063998 | 1.194 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.344104 | 0.463 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.385348 | 0.414 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.433287 | 0.363 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.442419 | 0.354 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.460244 | 0.337 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.360684 | 0.443 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.494209 | 0.306 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.494209 | 0.306 |
| R-HSA-9843745 | Adipogenesis | 0.426198 | 0.370 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.236211 | 0.627 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.236211 | 0.627 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.485286 | 0.314 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.077885 | 1.109 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.230261 | 0.638 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.295887 | 0.529 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.395129 | 0.403 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.301476 | 0.521 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.171663 | 0.765 |
| R-HSA-390650 | Histamine receptors | 0.077856 | 1.109 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.135768 | 0.867 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.253164 | 0.597 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.333369 | 0.477 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.127082 | 0.896 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.468942 | 0.329 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.510385 | 0.292 |
| R-HSA-4641258 | Degradation of DVL | 0.510385 | 0.292 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.297329 | 0.527 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.052499 | 1.280 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.109624 | 0.960 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.439681 | 0.357 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.360684 | 0.443 |
| R-HSA-447038 | NrCAM interactions | 0.107280 | 0.969 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.121639 | 0.915 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.149671 | 0.825 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.176812 | 0.752 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.062828 | 1.202 |
| R-HSA-2214320 | Anchoring fibril formation | 0.215913 | 0.666 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.228532 | 0.641 |
| R-HSA-9857492 | Protein lipoylation | 0.265185 | 0.576 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.277013 | 0.557 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.288652 | 0.540 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.322460 | 0.492 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.404990 | 0.393 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.343189 | 0.464 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.502362 | 0.299 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.502362 | 0.299 |
| R-HSA-4641257 | Degradation of AXIN | 0.510385 | 0.292 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.510385 | 0.292 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.113037 | 0.947 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.206584 | 0.685 |
| R-HSA-69236 | G1 Phase | 0.206584 | 0.685 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.286422 | 0.543 |
| R-HSA-9659379 | Sensory processing of sound | 0.168562 | 0.773 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.375285 | 0.426 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.428705 | 0.368 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.038157 | 1.418 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.192642 | 0.715 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.212481 | 0.673 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.433287 | 0.363 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.468942 | 0.329 |
| R-HSA-373760 | L1CAM interactions | 0.352391 | 0.453 |
| R-HSA-9671793 | Diseases of hemostasis | 0.322460 | 0.492 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.116345 | 0.934 |
| R-HSA-437239 | Recycling pathway of L1 | 0.224322 | 0.649 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.385508 | 0.414 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.502362 | 0.299 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.148995 | 0.827 |
| R-HSA-69481 | G2/M Checkpoints | 0.404728 | 0.393 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.247277 | 0.607 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.107280 | 0.969 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.121639 | 0.915 |
| R-HSA-164944 | Nef and signal transduction | 0.135768 | 0.867 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.038628 | 1.413 |
| R-HSA-447041 | CHL1 interactions | 0.149671 | 0.825 |
| R-HSA-448706 | Interleukin-1 processing | 0.176812 | 0.752 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.176812 | 0.752 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.240947 | 0.618 |
| R-HSA-9930044 | Nuclear RNA decay | 0.132436 | 0.878 |
| R-HSA-70350 | Fructose catabolism | 0.277013 | 0.557 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.365059 | 0.438 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.404990 | 0.393 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.301838 | 0.520 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.442419 | 0.354 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.468942 | 0.329 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.477501 | 0.321 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.477501 | 0.321 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.485923 | 0.313 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.485923 | 0.313 |
| R-HSA-169911 | Regulation of Apoptosis | 0.494209 | 0.306 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.406425 | 0.391 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.502362 | 0.299 |
| R-HSA-69206 | G1/S Transition | 0.193764 | 0.713 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.334795 | 0.475 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.405604 | 0.392 |
| R-HSA-1640170 | Cell Cycle | 0.137438 | 0.862 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.160831 | 0.794 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.090803 | 1.042 |
| R-HSA-9833110 | RSV-host interactions | 0.290804 | 0.536 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.288652 | 0.540 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.311372 | 0.507 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.212481 | 0.673 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.212481 | 0.673 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.404990 | 0.393 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.313714 | 0.503 |
| R-HSA-68886 | M Phase | 0.479549 | 0.319 |
| R-HSA-1442490 | Collagen degradation | 0.307781 | 0.512 |
| R-HSA-69275 | G2/M Transition | 0.118555 | 0.926 |
| R-HSA-5688426 | Deubiquitination | 0.288981 | 0.539 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.018424 | 1.735 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.176812 | 0.752 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.300104 | 0.523 |
| R-HSA-8875878 | MET promotes cell motility | 0.165941 | 0.780 |
| R-HSA-77387 | Insulin receptor recycling | 0.424007 | 0.373 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.122523 | 0.912 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.451403 | 0.345 |
| R-HSA-202424 | Downstream TCR signaling | 0.477157 | 0.321 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.414576 | 0.382 |
| R-HSA-5617833 | Cilium Assembly | 0.126556 | 0.898 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.450540 | 0.346 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.005581 | 2.253 |
| R-HSA-9664873 | Pexophagy | 0.190057 | 0.721 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.265185 | 0.576 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.395248 | 0.403 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.395248 | 0.403 |
| R-HSA-1483255 | PI Metabolism | 0.277673 | 0.556 |
| R-HSA-2559583 | Cellular Senescence | 0.107048 | 0.970 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.344104 | 0.463 |
| R-HSA-5652084 | Fructose metabolism | 0.365059 | 0.438 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.277995 | 0.556 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.450540 | 0.346 |
| R-HSA-73894 | DNA Repair | 0.419534 | 0.377 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.385273 | 0.414 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.228532 | 0.641 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.240947 | 0.618 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.322460 | 0.492 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.354666 | 0.450 |
| R-HSA-71384 | Ethanol oxidation | 0.365059 | 0.438 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.277995 | 0.556 |
| R-HSA-70635 | Urea cycle | 0.404990 | 0.393 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.433287 | 0.363 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.510385 | 0.292 |
| R-HSA-373755 | Semaphorin interactions | 0.319636 | 0.495 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.504110 | 0.297 |
| R-HSA-9707616 | Heme signaling | 0.313714 | 0.503 |
| R-HSA-3214842 | HDMs demethylate histones | 0.090803 | 1.042 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.277013 | 0.557 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.319636 | 0.495 |
| R-HSA-8848021 | Signaling by PTK6 | 0.319636 | 0.495 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.477501 | 0.321 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.301838 | 0.520 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.033561 | 1.474 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.375285 | 0.426 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.056916 | 1.245 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.365059 | 0.438 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.442419 | 0.354 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.307781 | 0.512 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.163351 | 0.787 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.176812 | 0.752 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.066993 | 1.174 |
| R-HSA-446728 | Cell junction organization | 0.211860 | 0.674 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.060285 | 1.220 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.473859 | 0.324 |
| R-HSA-1500931 | Cell-Cell communication | 0.181886 | 0.740 |
| R-HSA-180292 | GAB1 signalosome | 0.311372 | 0.507 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.485923 | 0.313 |
| R-HSA-9758941 | Gastrulation | 0.287059 | 0.542 |
| R-HSA-162582 | Signal Transduction | 0.365682 | 0.437 |
| R-HSA-4839726 | Chromatin organization | 0.073816 | 1.132 |
| R-HSA-5673000 | RAF activation | 0.143429 | 0.843 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.311372 | 0.507 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.333369 | 0.477 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.354666 | 0.450 |
| R-HSA-177929 | Signaling by EGFR | 0.086927 | 1.061 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.264603 | 0.577 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.095767 | 1.019 |
| R-HSA-435354 | Zinc transporters | 0.253164 | 0.597 |
| R-HSA-373753 | Nephrin family interactions | 0.333369 | 0.477 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.455925 | 0.341 |
| R-HSA-9833482 | PKR-mediated signaling | 0.417619 | 0.379 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.212481 | 0.673 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.002993 | 2.524 |
| R-HSA-8948216 | Collagen chain trimerization | 0.160254 | 0.795 |
| R-HSA-210993 | Tie2 Signaling | 0.311372 | 0.507 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.322460 | 0.492 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.510385 | 0.292 |
| R-HSA-6807070 | PTEN Regulation | 0.464125 | 0.333 |
| R-HSA-8983711 | OAS antiviral response | 0.228532 | 0.641 |
| R-HSA-3000170 | Syndecan interactions | 0.375285 | 0.426 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.254103 | 0.595 |
| R-HSA-6806834 | Signaling by MET | 0.172512 | 0.763 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.378005 | 0.423 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.322460 | 0.492 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.368641 | 0.433 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.127016 | 0.896 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.375285 | 0.426 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.455786 | 0.341 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.203090 | 0.692 |
| R-HSA-182971 | EGFR downregulation | 0.451403 | 0.345 |
| R-HSA-73887 | Death Receptor Signaling | 0.149417 | 0.826 |
| R-HSA-354192 | Integrin signaling | 0.468942 | 0.329 |
| R-HSA-622312 | Inflammasomes | 0.424007 | 0.373 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.290654 | 0.537 |
| R-HSA-109581 | Apoptosis | 0.334178 | 0.476 |
| R-HSA-75153 | Apoptotic execution phase | 0.218395 | 0.661 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.494209 | 0.306 |
| R-HSA-449147 | Signaling by Interleukins | 0.356486 | 0.448 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.331441 | 0.480 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.482387 | 0.317 |
| R-HSA-5357801 | Programmed Cell Death | 0.495655 | 0.305 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.218395 | 0.661 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.395129 | 0.403 |
| R-HSA-75893 | TNF signaling | 0.277995 | 0.556 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.442419 | 0.354 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.461280 | 0.336 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.512909 | 0.290 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.518072 | 0.286 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.518072 | 0.286 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.518072 | 0.286 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.518278 | 0.285 |
| R-HSA-397014 | Muscle contraction | 0.519496 | 0.284 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.520812 | 0.283 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.522860 | 0.282 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.523036 | 0.281 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.526045 | 0.279 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.526045 | 0.279 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.526045 | 0.279 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.526045 | 0.279 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.526045 | 0.279 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.526045 | 0.279 |
| R-HSA-422356 | Regulation of insulin secretion | 0.527965 | 0.277 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.528646 | 0.277 |
| R-HSA-1989781 | PPARA activates gene expression | 0.532536 | 0.274 |
| R-HSA-3214847 | HATs acetylate histones | 0.532860 | 0.273 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.533559 | 0.273 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.533687 | 0.273 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.533687 | 0.273 |
| R-HSA-167169 | HIV Transcription Elongation | 0.533687 | 0.273 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.533687 | 0.273 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.533687 | 0.273 |
| R-HSA-5260271 | Diseases of Immune System | 0.533687 | 0.273 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.533687 | 0.273 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.540262 | 0.267 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.541206 | 0.267 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.541206 | 0.267 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.541206 | 0.267 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.541206 | 0.267 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.541206 | 0.267 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.541206 | 0.267 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.541206 | 0.267 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.542545 | 0.266 |
| R-HSA-877300 | Interferon gamma signaling | 0.547915 | 0.261 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.548604 | 0.261 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.548604 | 0.261 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.548604 | 0.261 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.548604 | 0.261 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.548604 | 0.261 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.548604 | 0.261 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.548604 | 0.261 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.548604 | 0.261 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.548604 | 0.261 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.551714 | 0.258 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.551714 | 0.258 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.555884 | 0.255 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.555884 | 0.255 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.563046 | 0.249 |
| R-HSA-162906 | HIV Infection | 0.568712 | 0.245 |
| R-HSA-9907900 | Proteasome assembly | 0.570094 | 0.244 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.570094 | 0.244 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.570094 | 0.244 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.570094 | 0.244 |
| R-HSA-373752 | Netrin-1 signaling | 0.570094 | 0.244 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.570759 | 0.244 |
| R-HSA-69239 | Synthesis of DNA | 0.575337 | 0.240 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.577028 | 0.239 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.577028 | 0.239 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.577028 | 0.239 |
| R-HSA-9824272 | Somitogenesis | 0.577028 | 0.239 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.579880 | 0.237 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.583851 | 0.234 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.583851 | 0.234 |
| R-HSA-9675135 | Diseases of DNA repair | 0.583851 | 0.234 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.583851 | 0.234 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.583851 | 0.234 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.583851 | 0.234 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.584387 | 0.233 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.584387 | 0.233 |
| R-HSA-202403 | TCR signaling | 0.588859 | 0.230 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.590564 | 0.229 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.590564 | 0.229 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.590564 | 0.229 |
| R-HSA-425410 | Metal ion SLC transporters | 0.597169 | 0.224 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.599336 | 0.222 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.602059 | 0.220 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.602860 | 0.220 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.603668 | 0.219 |
| R-HSA-9766229 | Degradation of CDH1 | 0.603668 | 0.219 |
| R-HSA-73893 | DNA Damage Bypass | 0.603668 | 0.219 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.606388 | 0.217 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.607996 | 0.216 |
| R-HSA-157118 | Signaling by NOTCH | 0.609030 | 0.215 |
| R-HSA-9748787 | Azathioprine ADME | 0.610063 | 0.215 |
| R-HSA-912446 | Meiotic recombination | 0.616355 | 0.210 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.616355 | 0.210 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.616355 | 0.210 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.616355 | 0.210 |
| R-HSA-74160 | Gene expression (Transcription) | 0.621178 | 0.207 |
| R-HSA-72187 | mRNA 3'-end processing | 0.622546 | 0.206 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.622546 | 0.206 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.622546 | 0.206 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.622546 | 0.206 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.622546 | 0.206 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.622546 | 0.206 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.627498 | 0.202 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.628637 | 0.202 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.628637 | 0.202 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.628637 | 0.202 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.628637 | 0.202 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.628637 | 0.202 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.628637 | 0.202 |
| R-HSA-5693538 | Homology Directed Repair | 0.631613 | 0.200 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.634630 | 0.197 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.636967 | 0.196 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.640527 | 0.193 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.640527 | 0.193 |
| R-HSA-9753281 | Paracetamol ADME | 0.640527 | 0.193 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.643747 | 0.191 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.646329 | 0.190 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.646329 | 0.190 |
| R-HSA-5578775 | Ion homeostasis | 0.646329 | 0.190 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.646329 | 0.190 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.646329 | 0.190 |
| R-HSA-199991 | Membrane Trafficking | 0.646618 | 0.189 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.652038 | 0.186 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.652038 | 0.186 |
| R-HSA-212436 | Generic Transcription Pathway | 0.652638 | 0.185 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.655564 | 0.183 |
| R-HSA-983712 | Ion channel transport | 0.656431 | 0.183 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.657655 | 0.182 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.657655 | 0.182 |
| R-HSA-186712 | Regulation of beta-cell development | 0.663182 | 0.178 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.663182 | 0.178 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.668620 | 0.175 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.668620 | 0.175 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.668620 | 0.175 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.668620 | 0.175 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.668620 | 0.175 |
| R-HSA-983189 | Kinesins | 0.668620 | 0.175 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.668620 | 0.175 |
| R-HSA-351202 | Metabolism of polyamines | 0.668620 | 0.175 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.668620 | 0.175 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.669948 | 0.174 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.673970 | 0.171 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.673970 | 0.171 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.679234 | 0.168 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.679234 | 0.168 |
| R-HSA-186797 | Signaling by PDGF | 0.679234 | 0.168 |
| R-HSA-211981 | Xenobiotics | 0.689510 | 0.161 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.689510 | 0.161 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.690147 | 0.161 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.690147 | 0.161 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.692706 | 0.159 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.692706 | 0.159 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.694525 | 0.158 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.694525 | 0.158 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.695693 | 0.158 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.699458 | 0.155 |
| R-HSA-422475 | Axon guidance | 0.700446 | 0.155 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.702956 | 0.153 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.704312 | 0.152 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.704312 | 0.152 |
| R-HSA-167172 | Transcription of the HIV genome | 0.709089 | 0.149 |
| R-HSA-163685 | Integration of energy metabolism | 0.710008 | 0.149 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.718411 | 0.144 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.718411 | 0.144 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.718411 | 0.144 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.722528 | 0.141 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.722961 | 0.141 |
| R-HSA-3000178 | ECM proteoglycans | 0.722961 | 0.141 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.722961 | 0.141 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.722961 | 0.141 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.722961 | 0.141 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.722961 | 0.141 |
| R-HSA-9664407 | Parasite infection | 0.723260 | 0.141 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.723260 | 0.141 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.723260 | 0.141 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.726492 | 0.139 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.727437 | 0.138 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.727437 | 0.138 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.727437 | 0.138 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.727437 | 0.138 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.731841 | 0.136 |
| R-HSA-9749641 | Aspirin ADME | 0.731841 | 0.136 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.732861 | 0.135 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.736174 | 0.133 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.736174 | 0.133 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.739104 | 0.131 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.740437 | 0.131 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.740437 | 0.131 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.740437 | 0.131 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.740437 | 0.131 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.748235 | 0.126 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.748759 | 0.126 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.748759 | 0.126 |
| R-HSA-69242 | S Phase | 0.751218 | 0.124 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.752820 | 0.123 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.752820 | 0.123 |
| R-HSA-5619084 | ABC transporter disorders | 0.752820 | 0.123 |
| R-HSA-4086400 | PCP/CE pathway | 0.752820 | 0.123 |
| R-HSA-216083 | Integrin cell surface interactions | 0.752820 | 0.123 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.757092 | 0.121 |
| R-HSA-109582 | Hemostasis | 0.759020 | 0.120 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.759984 | 0.119 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.760746 | 0.119 |
| R-HSA-9675108 | Nervous system development | 0.763773 | 0.117 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.764614 | 0.117 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.764614 | 0.117 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.764614 | 0.117 |
| R-HSA-69306 | DNA Replication | 0.765679 | 0.116 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.768419 | 0.114 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.772163 | 0.112 |
| R-HSA-9612973 | Autophagy | 0.774002 | 0.111 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.775847 | 0.110 |
| R-HSA-162587 | HIV Life Cycle | 0.776718 | 0.110 |
| R-HSA-9610379 | HCMV Late Events | 0.776718 | 0.110 |
| R-HSA-9711097 | Cellular response to starvation | 0.779406 | 0.108 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.779406 | 0.108 |
| R-HSA-1500620 | Meiosis | 0.779472 | 0.108 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.779472 | 0.108 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.783038 | 0.106 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.783038 | 0.106 |
| R-HSA-913531 | Interferon Signaling | 0.785204 | 0.105 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.786546 | 0.104 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.789998 | 0.102 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.789998 | 0.102 |
| R-HSA-70268 | Pyruvate metabolism | 0.789998 | 0.102 |
| R-HSA-9663891 | Selective autophagy | 0.793395 | 0.101 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.794949 | 0.100 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.796737 | 0.099 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.800025 | 0.097 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.803259 | 0.095 |
| R-HSA-391251 | Protein folding | 0.809574 | 0.092 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.809574 | 0.092 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.809574 | 0.092 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.809574 | 0.092 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.814166 | 0.089 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.815686 | 0.088 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.818713 | 0.087 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.818713 | 0.087 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.820949 | 0.086 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.821603 | 0.085 |
| R-HSA-1474244 | Extracellular matrix organization | 0.821886 | 0.085 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.823161 | 0.085 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.825847 | 0.083 |
| R-HSA-9679506 | SARS-CoV Infections | 0.827035 | 0.082 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.827331 | 0.082 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.830126 | 0.081 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.830126 | 0.081 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.830126 | 0.081 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.835581 | 0.078 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.835581 | 0.078 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.835581 | 0.078 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.840861 | 0.075 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.846904 | 0.072 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.850921 | 0.070 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.850921 | 0.070 |
| R-HSA-418346 | Platelet homeostasis | 0.853335 | 0.069 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.855710 | 0.068 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.855710 | 0.068 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.857182 | 0.067 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.858047 | 0.066 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.858047 | 0.066 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.860347 | 0.065 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.862609 | 0.064 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.862609 | 0.064 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.864269 | 0.063 |
| R-HSA-6803157 | Antimicrobial peptides | 0.864835 | 0.063 |
| R-HSA-9658195 | Leishmania infection | 0.867196 | 0.062 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.867196 | 0.062 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.869179 | 0.061 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.874300 | 0.058 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.875436 | 0.058 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.875904 | 0.058 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.875904 | 0.058 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.877454 | 0.057 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.877454 | 0.057 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.885208 | 0.053 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.885208 | 0.053 |
| R-HSA-1483257 | Phospholipid metabolism | 0.886372 | 0.052 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.886372 | 0.052 |
| R-HSA-68875 | Mitotic Prophase | 0.887069 | 0.052 |
| R-HSA-6798695 | Neutrophil degranulation | 0.888601 | 0.051 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.888900 | 0.051 |
| R-HSA-195721 | Signaling by WNT | 0.890147 | 0.051 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.890701 | 0.050 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.890701 | 0.050 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.891111 | 0.050 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.892473 | 0.049 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.894217 | 0.049 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.894417 | 0.048 |
| R-HSA-9824446 | Viral Infection Pathways | 0.894493 | 0.048 |
| R-HSA-68882 | Mitotic Anaphase | 0.896468 | 0.047 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.896699 | 0.047 |
| R-HSA-194138 | Signaling by VEGF | 0.897620 | 0.047 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.897809 | 0.047 |
| R-HSA-418990 | Adherens junctions interactions | 0.899134 | 0.046 |
| R-HSA-9748784 | Drug ADME | 0.899134 | 0.046 |
| R-HSA-114608 | Platelet degranulation | 0.900914 | 0.045 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.906196 | 0.043 |
| R-HSA-1474165 | Reproduction | 0.907188 | 0.042 |
| R-HSA-5576891 | Cardiac conduction | 0.908694 | 0.042 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.911530 | 0.040 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.911633 | 0.040 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.912688 | 0.040 |
| R-HSA-2262752 | Cellular responses to stress | 0.916662 | 0.038 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.917231 | 0.038 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.917231 | 0.038 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.919896 | 0.036 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.919896 | 0.036 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.921456 | 0.036 |
| R-HSA-1632852 | Macroautophagy | 0.923735 | 0.034 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.926191 | 0.033 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.927390 | 0.033 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.927390 | 0.033 |
| R-HSA-2187338 | Visual phototransduction | 0.931993 | 0.031 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.933097 | 0.030 |
| R-HSA-9609646 | HCMV Infection | 0.933963 | 0.030 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.933964 | 0.030 |
| R-HSA-421270 | Cell-cell junction organization | 0.934843 | 0.029 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.937340 | 0.028 |
| R-HSA-9609507 | Protein localization | 0.938358 | 0.028 |
| R-HSA-8953854 | Metabolism of RNA | 0.939043 | 0.027 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.939231 | 0.027 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.939360 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 0.945318 | 0.024 |
| R-HSA-1266738 | Developmental Biology | 0.948406 | 0.023 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.948623 | 0.023 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.950997 | 0.022 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.954108 | 0.020 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.954805 | 0.020 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.965845 | 0.015 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.967487 | 0.014 |
| R-HSA-6805567 | Keratinization | 0.975003 | 0.011 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.975773 | 0.011 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.975773 | 0.011 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.977351 | 0.010 |
| R-HSA-8951664 | Neddylation | 0.980468 | 0.009 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.981200 | 0.008 |
| R-HSA-72312 | rRNA processing | 0.983703 | 0.007 |
| R-HSA-15869 | Metabolism of nucleotides | 0.984742 | 0.007 |
| R-HSA-8939211 | ESR-mediated signaling | 0.984991 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.986434 | 0.006 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.987271 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 0.989190 | 0.005 |
| R-HSA-1280218 | Adaptive Immune System | 0.991169 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.991693 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994227 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.995736 | 0.002 |
| R-HSA-168256 | Immune System | 0.996535 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.998162 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998207 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998712 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.998865 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998902 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999058 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999103 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999366 | 0.000 |
| R-HSA-72766 | Translation | 0.999387 | 0.000 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.999603 | 0.000 |
| R-HSA-1643685 | Disease | 0.999673 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999695 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999958 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999984 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999995 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.879 | 0.783 | 1 | 0.766 |
CDK19 |
0.877 | 0.831 | 1 | 0.823 |
P38G |
0.876 | 0.887 | 1 | 0.880 |
CDK17 |
0.875 | 0.865 | 1 | 0.871 |
CDK1 |
0.875 | 0.850 | 1 | 0.820 |
CDK3 |
0.874 | 0.780 | 1 | 0.864 |
CDK8 |
0.873 | 0.834 | 1 | 0.790 |
CDK18 |
0.873 | 0.840 | 1 | 0.839 |
JNK2 |
0.872 | 0.890 | 1 | 0.839 |
HIPK2 |
0.872 | 0.777 | 1 | 0.823 |
CDK13 |
0.870 | 0.854 | 1 | 0.815 |
CDK7 |
0.869 | 0.823 | 1 | 0.795 |
CDK12 |
0.867 | 0.852 | 1 | 0.836 |
CDK5 |
0.866 | 0.822 | 1 | 0.765 |
ERK1 |
0.866 | 0.840 | 1 | 0.819 |
JNK3 |
0.864 | 0.879 | 1 | 0.812 |
CDK16 |
0.864 | 0.826 | 1 | 0.856 |
CDK10 |
0.864 | 0.806 | 1 | 0.815 |
P38B |
0.862 | 0.839 | 1 | 0.803 |
P38D |
0.862 | 0.853 | 1 | 0.875 |
DYRK2 |
0.862 | 0.762 | 1 | 0.736 |
DYRK4 |
0.862 | 0.783 | 1 | 0.834 |
CLK3 |
0.860 | 0.546 | 1 | 0.485 |
CDK9 |
0.859 | 0.830 | 1 | 0.808 |
CDK14 |
0.855 | 0.815 | 1 | 0.798 |
ERK2 |
0.853 | 0.839 | 1 | 0.769 |
DYRK1B |
0.852 | 0.745 | 1 | 0.788 |
P38A |
0.852 | 0.810 | 1 | 0.734 |
HIPK1 |
0.852 | 0.707 | 1 | 0.716 |
CDK4 |
0.851 | 0.838 | 1 | 0.844 |
CDK6 |
0.850 | 0.818 | 1 | 0.817 |
NLK |
0.848 | 0.750 | 1 | 0.527 |
SRPK1 |
0.848 | 0.388 | -3 | 0.764 |
CDK2 |
0.847 | 0.668 | 1 | 0.698 |
HIPK4 |
0.844 | 0.472 | 1 | 0.519 |
HIPK3 |
0.843 | 0.687 | 1 | 0.688 |
JNK1 |
0.843 | 0.785 | 1 | 0.842 |
CLK2 |
0.842 | 0.459 | -3 | 0.766 |
DYRK1A |
0.841 | 0.615 | 1 | 0.699 |
CLK1 |
0.839 | 0.449 | -3 | 0.774 |
SRPK2 |
0.838 | 0.319 | -3 | 0.687 |
DYRK3 |
0.834 | 0.561 | 1 | 0.679 |
ERK5 |
0.833 | 0.391 | 1 | 0.437 |
CLK4 |
0.833 | 0.403 | -3 | 0.786 |
MTOR |
0.828 | 0.220 | 1 | 0.321 |
SRPK3 |
0.827 | 0.296 | -3 | 0.731 |
ICK |
0.826 | 0.366 | -3 | 0.854 |
COT |
0.822 | -0.061 | 2 | 0.882 |
CDKL5 |
0.822 | 0.170 | -3 | 0.809 |
CDKL1 |
0.820 | 0.151 | -3 | 0.815 |
MAK |
0.818 | 0.495 | -2 | 0.742 |
MOS |
0.818 | 0.012 | 1 | 0.198 |
PRP4 |
0.818 | 0.476 | -3 | 0.799 |
PRPK |
0.814 | -0.072 | -1 | 0.901 |
CDC7 |
0.813 | -0.117 | 1 | 0.158 |
MOK |
0.812 | 0.470 | 1 | 0.600 |
MST4 |
0.811 | -0.003 | 2 | 0.851 |
TBK1 |
0.811 | -0.168 | 1 | 0.115 |
NDR2 |
0.810 | -0.023 | -3 | 0.849 |
PIM3 |
0.810 | -0.026 | -3 | 0.846 |
GCN2 |
0.810 | -0.173 | 2 | 0.810 |
CAMK1B |
0.809 | -0.020 | -3 | 0.887 |
NUAK2 |
0.809 | 0.031 | -3 | 0.860 |
WNK1 |
0.809 | -0.049 | -2 | 0.868 |
BMPR2 |
0.807 | -0.138 | -2 | 0.884 |
PKN3 |
0.807 | -0.041 | -3 | 0.850 |
ATR |
0.806 | -0.068 | 1 | 0.185 |
PDHK4 |
0.806 | -0.177 | 1 | 0.202 |
IKKE |
0.806 | -0.182 | 1 | 0.115 |
RAF1 |
0.805 | -0.199 | 1 | 0.136 |
PRKD1 |
0.805 | -0.024 | -3 | 0.850 |
NDR1 |
0.805 | -0.039 | -3 | 0.852 |
DSTYK |
0.804 | -0.141 | 2 | 0.887 |
TGFBR2 |
0.804 | -0.075 | -2 | 0.810 |
PRKD2 |
0.804 | 0.003 | -3 | 0.800 |
CAMK2G |
0.803 | -0.085 | 2 | 0.829 |
PKN2 |
0.803 | -0.040 | -3 | 0.863 |
ULK2 |
0.803 | -0.196 | 2 | 0.797 |
RSK2 |
0.803 | -0.003 | -3 | 0.792 |
NIK |
0.803 | -0.048 | -3 | 0.905 |
PIM1 |
0.803 | 0.030 | -3 | 0.794 |
IKKB |
0.803 | -0.183 | -2 | 0.750 |
CHAK2 |
0.803 | -0.049 | -1 | 0.889 |
NEK6 |
0.801 | -0.100 | -2 | 0.848 |
PKCD |
0.801 | -0.020 | 2 | 0.782 |
GRK1 |
0.800 | -0.003 | -2 | 0.844 |
CAMLCK |
0.800 | -0.026 | -2 | 0.840 |
ERK7 |
0.800 | 0.249 | 2 | 0.487 |
P90RSK |
0.799 | -0.011 | -3 | 0.791 |
AMPKA1 |
0.799 | -0.052 | -3 | 0.876 |
RIPK3 |
0.799 | -0.142 | 3 | 0.758 |
PDHK1 |
0.799 | -0.200 | 1 | 0.178 |
RSK3 |
0.798 | -0.026 | -3 | 0.788 |
SKMLCK |
0.798 | -0.075 | -2 | 0.855 |
HUNK |
0.797 | -0.137 | 2 | 0.840 |
WNK3 |
0.797 | -0.177 | 1 | 0.134 |
MAPKAPK3 |
0.797 | -0.060 | -3 | 0.804 |
LATS2 |
0.797 | -0.051 | -5 | 0.759 |
IRE1 |
0.797 | -0.069 | 1 | 0.128 |
P70S6KB |
0.797 | -0.006 | -3 | 0.819 |
DAPK2 |
0.797 | -0.059 | -3 | 0.890 |
NEK7 |
0.796 | -0.193 | -3 | 0.837 |
MLK1 |
0.796 | -0.154 | 2 | 0.811 |
ULK1 |
0.796 | -0.171 | -3 | 0.836 |
AMPKA2 |
0.795 | -0.036 | -3 | 0.842 |
BMPR1B |
0.795 | -0.031 | 1 | 0.128 |
AURC |
0.795 | 0.002 | -2 | 0.647 |
PKACG |
0.795 | -0.037 | -2 | 0.737 |
MARK4 |
0.794 | -0.086 | 4 | 0.853 |
GRK5 |
0.794 | -0.159 | -3 | 0.869 |
CAMK2D |
0.793 | -0.107 | -3 | 0.872 |
MAPKAPK2 |
0.793 | -0.037 | -3 | 0.753 |
IRE2 |
0.793 | -0.051 | 2 | 0.740 |
TGFBR1 |
0.793 | -0.039 | -2 | 0.829 |
ALK4 |
0.792 | -0.047 | -2 | 0.849 |
PRKD3 |
0.792 | -0.011 | -3 | 0.773 |
DNAPK |
0.792 | -0.043 | 1 | 0.176 |
NUAK1 |
0.792 | -0.029 | -3 | 0.814 |
PHKG1 |
0.792 | -0.066 | -3 | 0.851 |
TSSK1 |
0.791 | -0.056 | -3 | 0.894 |
MASTL |
0.791 | -0.191 | -2 | 0.818 |
GRK7 |
0.791 | 0.006 | 1 | 0.168 |
PAK6 |
0.790 | -0.005 | -2 | 0.683 |
ATM |
0.790 | -0.086 | 1 | 0.154 |
IKKA |
0.790 | -0.124 | -2 | 0.742 |
TSSK2 |
0.790 | -0.091 | -5 | 0.836 |
MNK2 |
0.790 | -0.040 | -2 | 0.775 |
CAMK4 |
0.789 | -0.106 | -3 | 0.848 |
MLK2 |
0.789 | -0.154 | 2 | 0.822 |
RIPK1 |
0.789 | -0.190 | 1 | 0.125 |
PKR |
0.789 | -0.074 | 1 | 0.151 |
DLK |
0.789 | -0.202 | 1 | 0.151 |
PKCG |
0.789 | -0.039 | 2 | 0.730 |
MLK3 |
0.789 | -0.076 | 2 | 0.735 |
PKCB |
0.789 | -0.036 | 2 | 0.731 |
PAK3 |
0.789 | -0.079 | -2 | 0.773 |
MNK1 |
0.788 | -0.013 | -2 | 0.786 |
PKCA |
0.788 | -0.030 | 2 | 0.717 |
NIM1 |
0.788 | -0.105 | 3 | 0.770 |
PAK1 |
0.788 | -0.058 | -2 | 0.777 |
LATS1 |
0.788 | -0.017 | -3 | 0.863 |
NEK9 |
0.788 | -0.211 | 2 | 0.840 |
MPSK1 |
0.788 | 0.053 | 1 | 0.198 |
BCKDK |
0.787 | -0.187 | -1 | 0.792 |
VRK2 |
0.787 | 0.019 | 1 | 0.236 |
PINK1 |
0.787 | 0.155 | 1 | 0.344 |
MELK |
0.787 | -0.078 | -3 | 0.834 |
GRK6 |
0.787 | -0.148 | 1 | 0.138 |
GSK3A |
0.786 | 0.202 | 4 | 0.492 |
RSK4 |
0.786 | -0.002 | -3 | 0.748 |
TTBK2 |
0.786 | -0.177 | 2 | 0.722 |
ANKRD3 |
0.786 | -0.198 | 1 | 0.152 |
AKT2 |
0.786 | 0.020 | -3 | 0.708 |
PKCZ |
0.786 | -0.055 | 2 | 0.771 |
MSK2 |
0.785 | -0.059 | -3 | 0.755 |
PIM2 |
0.785 | 0.028 | -3 | 0.769 |
PKCH |
0.785 | -0.057 | 2 | 0.717 |
AURB |
0.785 | -0.025 | -2 | 0.645 |
CAMK2A |
0.785 | -0.035 | 2 | 0.819 |
CAMK2B |
0.784 | -0.067 | 2 | 0.798 |
PKACB |
0.784 | -0.001 | -2 | 0.665 |
ACVR2B |
0.783 | -0.088 | -2 | 0.812 |
PKG2 |
0.783 | -0.023 | -2 | 0.665 |
YSK4 |
0.783 | -0.171 | 1 | 0.122 |
GRK4 |
0.783 | -0.161 | -2 | 0.859 |
SGK3 |
0.783 | -0.021 | -3 | 0.785 |
CHAK1 |
0.783 | -0.123 | 2 | 0.785 |
MEK1 |
0.783 | -0.148 | 2 | 0.857 |
CAMK1G |
0.782 | -0.042 | -3 | 0.788 |
PLK1 |
0.782 | -0.147 | -2 | 0.812 |
QIK |
0.782 | -0.111 | -3 | 0.862 |
ACVR2A |
0.782 | -0.095 | -2 | 0.798 |
ALK2 |
0.782 | -0.065 | -2 | 0.837 |
SMG1 |
0.781 | -0.098 | 1 | 0.169 |
PRKX |
0.781 | 0.024 | -3 | 0.692 |
QSK |
0.781 | -0.060 | 4 | 0.834 |
MSK1 |
0.781 | -0.038 | -3 | 0.764 |
PHKG2 |
0.780 | -0.056 | -3 | 0.838 |
DCAMKL1 |
0.780 | -0.043 | -3 | 0.814 |
MYLK4 |
0.780 | -0.049 | -2 | 0.765 |
SIK |
0.779 | -0.063 | -3 | 0.789 |
BRSK2 |
0.779 | -0.099 | -3 | 0.850 |
NEK2 |
0.779 | -0.164 | 2 | 0.809 |
MST3 |
0.778 | -0.043 | 2 | 0.838 |
PAK2 |
0.778 | -0.092 | -2 | 0.761 |
HRI |
0.778 | -0.137 | -2 | 0.841 |
DRAK1 |
0.778 | -0.140 | 1 | 0.126 |
MLK4 |
0.777 | -0.130 | 2 | 0.713 |
WNK4 |
0.777 | -0.115 | -2 | 0.853 |
BRSK1 |
0.777 | -0.084 | -3 | 0.818 |
BMPR1A |
0.777 | -0.055 | 1 | 0.122 |
FAM20C |
0.776 | -0.043 | 2 | 0.612 |
CHK1 |
0.776 | -0.079 | -3 | 0.850 |
PERK |
0.776 | -0.139 | -2 | 0.838 |
GRK2 |
0.776 | -0.084 | -2 | 0.742 |
MAPKAPK5 |
0.775 | -0.104 | -3 | 0.741 |
PKCT |
0.775 | -0.059 | 2 | 0.725 |
PLK4 |
0.775 | -0.147 | 2 | 0.653 |
MARK3 |
0.775 | -0.060 | 4 | 0.799 |
TAO3 |
0.775 | -0.039 | 1 | 0.168 |
SNRK |
0.775 | -0.155 | 2 | 0.693 |
PLK3 |
0.775 | -0.133 | 2 | 0.800 |
MEK5 |
0.775 | -0.157 | 2 | 0.839 |
IRAK4 |
0.775 | -0.120 | 1 | 0.109 |
AKT1 |
0.775 | -0.004 | -3 | 0.729 |
GAK |
0.774 | -0.003 | 1 | 0.188 |
AURA |
0.774 | -0.047 | -2 | 0.622 |
DCAMKL2 |
0.774 | -0.052 | -3 | 0.841 |
TLK2 |
0.774 | -0.163 | 1 | 0.122 |
PKCI |
0.774 | -0.030 | 2 | 0.731 |
GSK3B |
0.774 | 0.055 | 4 | 0.484 |
MEKK3 |
0.773 | -0.157 | 1 | 0.142 |
MARK2 |
0.772 | -0.080 | 4 | 0.756 |
MEKK1 |
0.772 | -0.173 | 1 | 0.143 |
SMMLCK |
0.771 | -0.044 | -3 | 0.842 |
ZAK |
0.771 | -0.175 | 1 | 0.132 |
P70S6K |
0.771 | -0.026 | -3 | 0.730 |
PKCE |
0.771 | 0.002 | 2 | 0.713 |
TAO2 |
0.770 | -0.034 | 2 | 0.847 |
SSTK |
0.770 | -0.059 | 4 | 0.825 |
PAK5 |
0.770 | -0.046 | -2 | 0.626 |
PASK |
0.770 | -0.048 | -3 | 0.855 |
MEKK2 |
0.769 | -0.145 | 2 | 0.811 |
TLK1 |
0.769 | -0.147 | -2 | 0.847 |
PKACA |
0.768 | -0.017 | -2 | 0.611 |
CK1E |
0.768 | -0.029 | -3 | 0.519 |
BRAF |
0.768 | -0.162 | -4 | 0.861 |
NEK11 |
0.768 | -0.134 | 1 | 0.162 |
PAK4 |
0.767 | -0.037 | -2 | 0.634 |
MARK1 |
0.767 | -0.102 | 4 | 0.821 |
NEK5 |
0.767 | -0.186 | 1 | 0.127 |
PKN1 |
0.767 | -0.044 | -3 | 0.756 |
GCK |
0.765 | -0.066 | 1 | 0.145 |
CK2A2 |
0.765 | -0.053 | 1 | 0.124 |
HGK |
0.765 | -0.054 | 3 | 0.924 |
TTBK1 |
0.764 | -0.160 | 2 | 0.648 |
PDK1 |
0.764 | -0.088 | 1 | 0.179 |
HASPIN |
0.764 | 0.040 | -1 | 0.749 |
LKB1 |
0.764 | -0.079 | -3 | 0.856 |
MEKK6 |
0.764 | -0.099 | 1 | 0.139 |
TNIK |
0.764 | -0.029 | 3 | 0.922 |
CAMK1D |
0.763 | -0.048 | -3 | 0.712 |
MAP3K15 |
0.763 | -0.111 | 1 | 0.145 |
HPK1 |
0.763 | -0.058 | 1 | 0.145 |
CK1D |
0.762 | -0.005 | -3 | 0.470 |
BUB1 |
0.762 | 0.008 | -5 | 0.803 |
SBK |
0.762 | 0.094 | -3 | 0.594 |
KHS1 |
0.761 | -0.031 | 1 | 0.136 |
MINK |
0.761 | -0.102 | 1 | 0.118 |
PBK |
0.761 | -0.036 | 1 | 0.169 |
NEK8 |
0.761 | -0.185 | 2 | 0.818 |
MRCKB |
0.760 | -0.006 | -3 | 0.765 |
EEF2K |
0.760 | -0.047 | 3 | 0.900 |
AKT3 |
0.760 | -0.000 | -3 | 0.641 |
KHS2 |
0.759 | 0.001 | 1 | 0.149 |
LOK |
0.759 | -0.074 | -2 | 0.758 |
LRRK2 |
0.759 | -0.031 | 2 | 0.847 |
SGK1 |
0.759 | 0.017 | -3 | 0.622 |
CHK2 |
0.759 | -0.030 | -3 | 0.665 |
NEK4 |
0.758 | -0.177 | 1 | 0.114 |
DAPK3 |
0.758 | -0.055 | -3 | 0.821 |
MRCKA |
0.758 | -0.018 | -3 | 0.781 |
GRK3 |
0.758 | -0.091 | -2 | 0.709 |
IRAK1 |
0.757 | -0.220 | -1 | 0.796 |
CAMKK1 |
0.757 | -0.212 | -2 | 0.742 |
MST2 |
0.757 | -0.150 | 1 | 0.128 |
CK1G1 |
0.756 | -0.083 | -3 | 0.515 |
CAMKK2 |
0.756 | -0.170 | -2 | 0.732 |
CK2A1 |
0.756 | -0.060 | 1 | 0.119 |
DMPK1 |
0.755 | 0.029 | -3 | 0.789 |
CAMK1A |
0.755 | -0.033 | -3 | 0.683 |
SLK |
0.754 | -0.072 | -2 | 0.710 |
BIKE |
0.754 | -0.016 | 1 | 0.179 |
ROCK2 |
0.754 | -0.022 | -3 | 0.807 |
MST1 |
0.754 | -0.126 | 1 | 0.119 |
CK1A2 |
0.754 | -0.040 | -3 | 0.468 |
TAK1 |
0.754 | -0.178 | 1 | 0.123 |
NEK1 |
0.752 | -0.176 | 1 | 0.111 |
YSK1 |
0.752 | -0.114 | 2 | 0.807 |
VRK1 |
0.752 | -0.178 | 2 | 0.841 |
DAPK1 |
0.752 | -0.061 | -3 | 0.799 |
STK33 |
0.751 | -0.121 | 2 | 0.636 |
PDHK3_TYR |
0.751 | 0.124 | 4 | 0.912 |
RIPK2 |
0.751 | -0.207 | 1 | 0.119 |
AAK1 |
0.750 | 0.017 | 1 | 0.185 |
CRIK |
0.748 | 0.021 | -3 | 0.724 |
PKG1 |
0.746 | -0.050 | -2 | 0.586 |
TESK1_TYR |
0.745 | 0.043 | 3 | 0.884 |
LIMK2_TYR |
0.745 | 0.113 | -3 | 0.918 |
NEK3 |
0.745 | -0.140 | 1 | 0.142 |
PKMYT1_TYR |
0.744 | 0.115 | 3 | 0.858 |
MEK2 |
0.744 | -0.220 | 2 | 0.826 |
ROCK1 |
0.744 | -0.024 | -3 | 0.779 |
PLK2 |
0.743 | -0.099 | -3 | 0.786 |
PDHK4_TYR |
0.742 | 0.050 | 2 | 0.899 |
TAO1 |
0.741 | -0.078 | 1 | 0.137 |
OSR1 |
0.741 | -0.088 | 2 | 0.802 |
ASK1 |
0.740 | -0.135 | 1 | 0.145 |
MAP2K4_TYR |
0.740 | -0.013 | -1 | 0.906 |
MAP2K6_TYR |
0.740 | 0.025 | -1 | 0.912 |
BMPR2_TYR |
0.738 | 0.030 | -1 | 0.910 |
MYO3B |
0.738 | -0.078 | 2 | 0.818 |
MAP2K7_TYR |
0.738 | -0.083 | 2 | 0.878 |
PINK1_TYR |
0.738 | -0.085 | 1 | 0.194 |
MYO3A |
0.738 | -0.081 | 1 | 0.135 |
TTK |
0.737 | -0.104 | -2 | 0.831 |
PDHK1_TYR |
0.735 | -0.055 | -1 | 0.924 |
LIMK1_TYR |
0.734 | 0.001 | 2 | 0.861 |
ALPHAK3 |
0.733 | -0.091 | -1 | 0.819 |
RET |
0.730 | -0.152 | 1 | 0.158 |
MST1R |
0.730 | -0.107 | 3 | 0.829 |
JAK2 |
0.728 | -0.144 | 1 | 0.166 |
TYK2 |
0.728 | -0.199 | 1 | 0.143 |
NEK10_TYR |
0.728 | -0.099 | 1 | 0.142 |
CSF1R |
0.728 | -0.105 | 3 | 0.825 |
EPHA6 |
0.727 | -0.095 | -1 | 0.885 |
JAK3 |
0.727 | -0.105 | 1 | 0.157 |
TXK |
0.726 | -0.074 | 1 | 0.126 |
YES1 |
0.726 | -0.085 | -1 | 0.891 |
ROS1 |
0.725 | -0.146 | 3 | 0.808 |
TYRO3 |
0.725 | -0.165 | 3 | 0.833 |
TNNI3K_TYR |
0.723 | -0.038 | 1 | 0.171 |
LCK |
0.723 | -0.065 | -1 | 0.881 |
DDR1 |
0.723 | -0.137 | 4 | 0.829 |
JAK1 |
0.723 | -0.103 | 1 | 0.139 |
FGFR2 |
0.722 | -0.055 | 3 | 0.782 |
TEK |
0.722 | -0.013 | 3 | 0.756 |
EPHB4 |
0.721 | -0.153 | -1 | 0.853 |
ABL2 |
0.721 | -0.125 | -1 | 0.838 |
FGFR1 |
0.721 | -0.051 | 3 | 0.768 |
BLK |
0.721 | -0.059 | -1 | 0.885 |
YANK3 |
0.720 | -0.082 | 2 | 0.423 |
FGR |
0.720 | -0.159 | 1 | 0.124 |
HCK |
0.720 | -0.126 | -1 | 0.875 |
STLK3 |
0.719 | -0.203 | 1 | 0.116 |
FLT3 |
0.719 | -0.144 | 3 | 0.837 |
TNK1 |
0.719 | -0.090 | 3 | 0.808 |
ITK |
0.718 | -0.124 | -1 | 0.841 |
KIT |
0.718 | -0.123 | 3 | 0.817 |
INSRR |
0.718 | -0.140 | 3 | 0.762 |
KDR |
0.718 | -0.092 | 3 | 0.776 |
ABL1 |
0.717 | -0.131 | -1 | 0.832 |
TNK2 |
0.717 | -0.135 | 3 | 0.762 |
CK1A |
0.716 | -0.061 | -3 | 0.373 |
WEE1_TYR |
0.716 | -0.052 | -1 | 0.782 |
EPHA4 |
0.715 | -0.107 | 2 | 0.797 |
FYN |
0.714 | -0.057 | -1 | 0.873 |
PDGFRB |
0.714 | -0.206 | 3 | 0.830 |
SRMS |
0.714 | -0.184 | 1 | 0.114 |
FER |
0.713 | -0.212 | 1 | 0.137 |
MET |
0.713 | -0.109 | 3 | 0.795 |
BMX |
0.712 | -0.104 | -1 | 0.766 |
EPHB1 |
0.711 | -0.196 | 1 | 0.119 |
TEC |
0.711 | -0.131 | -1 | 0.775 |
DDR2 |
0.710 | -0.052 | 3 | 0.739 |
FGFR3 |
0.710 | -0.071 | 3 | 0.755 |
PDGFRA |
0.709 | -0.213 | 3 | 0.835 |
EPHB2 |
0.709 | -0.170 | -1 | 0.832 |
FRK |
0.709 | -0.129 | -1 | 0.868 |
EPHB3 |
0.709 | -0.192 | -1 | 0.833 |
FLT1 |
0.708 | -0.126 | -1 | 0.851 |
AXL |
0.708 | -0.198 | 3 | 0.778 |
BTK |
0.707 | -0.198 | -1 | 0.795 |
ERBB2 |
0.707 | -0.155 | 1 | 0.135 |
MERTK |
0.707 | -0.186 | 3 | 0.777 |
FLT4 |
0.706 | -0.147 | 3 | 0.760 |
LYN |
0.704 | -0.128 | 3 | 0.746 |
PTK2B |
0.704 | -0.115 | -1 | 0.813 |
EGFR |
0.703 | -0.109 | 1 | 0.114 |
SRC |
0.703 | -0.103 | -1 | 0.864 |
ALK |
0.702 | -0.188 | 3 | 0.742 |
EPHA7 |
0.702 | -0.157 | 2 | 0.795 |
EPHA1 |
0.701 | -0.182 | 3 | 0.780 |
INSR |
0.701 | -0.174 | 3 | 0.746 |
LTK |
0.699 | -0.197 | 3 | 0.753 |
NTRK2 |
0.699 | -0.226 | 3 | 0.768 |
NTRK1 |
0.699 | -0.238 | -1 | 0.828 |
EPHA3 |
0.699 | -0.164 | 2 | 0.770 |
PTK2 |
0.699 | -0.047 | -1 | 0.832 |
MUSK |
0.699 | -0.128 | 1 | 0.095 |
MATK |
0.697 | -0.111 | -1 | 0.767 |
EPHA8 |
0.697 | -0.128 | -1 | 0.831 |
SYK |
0.697 | -0.063 | -1 | 0.812 |
PTK6 |
0.696 | -0.234 | -1 | 0.763 |
NTRK3 |
0.696 | -0.182 | -1 | 0.777 |
FGFR4 |
0.694 | -0.121 | -1 | 0.793 |
EPHA5 |
0.694 | -0.164 | 2 | 0.781 |
ERBB4 |
0.693 | -0.086 | 1 | 0.110 |
CSK |
0.693 | -0.169 | 2 | 0.801 |
CK1G3 |
0.691 | -0.075 | -3 | 0.322 |
YANK2 |
0.686 | -0.101 | 2 | 0.435 |
EPHA2 |
0.685 | -0.146 | -1 | 0.788 |
IGF1R |
0.685 | -0.162 | 3 | 0.675 |
ZAP70 |
0.684 | -0.049 | -1 | 0.746 |
CK1G2 |
0.676 | -0.062 | -3 | 0.425 |
FES |
0.672 | -0.160 | -1 | 0.745 |