Motif 619 (n=168)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S37 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A0A0B4J203 | None | S85 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A3KN83 | SBNO1 | S904 | ochoa | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}. |
| A5YM69 | ARHGEF35 | S57 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| B5ME19 | EIF3CL | S178 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| F6TDL0 | P3R3URF-PIK3R3 | S232 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. {ECO:0000256|ARBA:ARBA00057933}. |
| H3BU86 | STX16-NPEPL1 | S201 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| O00566 | MPHOSPH10 | S139 | ochoa | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| O14662 | STX16 | S201 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14976 | GAK | S817 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15273 | TCAP | S39 | ochoa | Telethonin (Titin cap protein) | Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk. |
| O15409 | FOXP2 | S696 | ochoa | Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| O43493 | TGOLN2 | S315 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43719 | HTATSF1 | S713 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43823 | AKAP8 | S339 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60271 | SPAG9 | S314 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75121 | MFAP3L | S360 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75264 | SMIM24 | S108 | ochoa | Small integral membrane protein 24 | None |
| O94880 | PHF14 | S232 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95125 | ZNF202 | S33 | ochoa | Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) | Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. |
| O95218 | ZRANB2 | S165 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95801 | TTC4 | S47 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| P06213 | INSR | S1064 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P07947 | YES1 | S195 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P10451 | SPP1 | S81 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11055 | MYH3 | S949 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S952 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S948 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S950 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S951 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14317 | HCLS1 | Y378 | psp | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P15884 | TCF4 | S543 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P19338 | NCL | S184 | ochoa|psp | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20273 | CD22 | S797 | ochoa | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) | Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}. |
| P23246 | SFPQ | S491 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P28340 | POLD1 | S60 | ochoa | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200, PubMed:31449058). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites (PubMed:19074196, PubMed:24191025). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:31449058}. |
| P28715 | ERCC5 | S559 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P28715 | ERCC5 | S697 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P28715 | ERCC5 | S699 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29350 | PTPN6 | S250 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P29375 | KDM5A | S1598 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P39880 | CUX1 | S1378 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40261 | NNMT | S108 | ochoa | Nicotinamide N-methyltransferase (EC 2.1.1.1) | Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}. |
| P41743 | PRKCI | S248 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P46100 | ATRX | S48 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S992 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S517 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S965 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S244 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49756 | RBM25 | S516 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49792 | RANBP2 | S2693 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50579 | METAP2 | S45 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P51858 | HDGF | S103 | ochoa | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52948 | NUP98 | S635 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P55884 | EIF3B | S152 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q00653 | NFKB2 | S866 | ochoa|psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00987 | MDM2 | Y405 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01105 | SET | S133 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q02410 | APBA1 | S285 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q03188 | CENPC | S290 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08J23 | NSUN2 | S724 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q0JRZ9 | FCHO2 | S312 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q0ZGT2 | NEXN | S226 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12774 | ARHGEF5 | S57 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12830 | BPTF | S737 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13094 | LCP2 | Y113 | psp | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13428 | TCOF1 | S1410 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13435 | SF3B2 | S431 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13442 | PDAP1 | S57 | ochoa | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}. |
| Q13501 | SQSTM1 | S332 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q14152 | EIF3A | S882 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14159 | SPIDR | S132 | ochoa | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:27967308, ECO:0000269|PubMed:34697795}. |
| Q14676 | MDC1 | S397 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14839 | CHD4 | S1245 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q14BN4 | SLMAP | S459 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q15059 | BRD3 | S359 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q32MZ4 | LRRFIP1 | S735 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q49MG5 | MAP9 | S305 | psp | Microtubule-associated protein 9 (Aster-associated protein) | Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}. |
| Q5T011 | SZT2 | S1389 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T8I3 | EEIG2 | S276 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5TH69 | ARFGEF3 | S1848 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5UIP0 | RIF1 | S1513 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1576 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1579 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZP5 | STYXL2 | S1065 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q63HQ0 | AP1AR | S147 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q69YH5 | CDCA2 | S893 | psp | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6UN15 | FIP1L1 | S37 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6UN15 | FIP1L1 | S85 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6VY07 | PACS1 | S379 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6VY07 | PACS1 | S451 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q71F23 | CENPU | S158 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7L014 | DDX46 | S199 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
| Q7Z3T8 | ZFYVE16 | S348 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z4V5 | HDGFL2 | S366 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z6E9 | RBBP6 | S815 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6I6 | ARHGAP30 | S332 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z7L9 | ZSCAN2 | S168 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q86UR5 | RIMS1 | S324 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86W50 | METTL16 | S484 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IUI4 | SNX29P2 | S191 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IWU2 | LMTK2 | S788 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N7H5 | PAF1 | S456 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
| Q8TEQ0 | SNX29 | S344 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WYP5 | AHCTF1 | S1371 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92569 | PIK3R3 | S186 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| Q92736 | RYR2 | S2368 | psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q92786 | PROX1 | S291 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92922 | SMARCC1 | S816 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96GA3 | LTV1 | S188 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96K76 | USP47 | S917 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96K76 | USP47 | S940 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96K76 | USP47 | S1013 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96L73 | NSD1 | S1139 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96QT4 | TRPM7 | S1500 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96SB4 | SRPK1 | S334 | ochoa | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99081 | TCF12 | S535 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99549 | MPHOSPH8 | S266 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99549 | MPHOSPH8 | S272 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99613 | EIF3C | S178 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q9BTC0 | DIDO1 | S352 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BV36 | MLPH | S397 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXL5 | HEMGN | S188 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BXW9 | FANCD2 | S1423 | ochoa | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BY89 | KIAA1671 | S1695 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0D2 | CEP295 | S1205 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9H2H9 | SLC38A1 | S25 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2P0 | ADNP | S1067 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H788 | SH2D4A | S124 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9NYF8 | BCLAF1 | S389 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYH9 | UTP6 | S204 | ochoa | U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9NZ53 | PODXL2 | S558 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9NZB2 | FAM120A | S1041 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P2I0 | CPSF2 | S419 | ochoa | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
| Q9P2W9 | STX18 | S283 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UGP8 | SEC63 | S570 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UGP8 | SEC63 | S593 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UH62 | ARMCX3 | S53 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHR5 | SAP30BP | S52 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UHW9 | SLC12A6 | S1029 | ochoa|psp | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UKX2 | MYH2 | S954 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKY7 | CDV3 | S107 | ochoa | Protein CDV3 homolog | None |
| Q9Y247 | FAM50B | S121 | ochoa | Protein FAM50B (Protein XAP-5-like) | None |
| Q9Y4D1 | DAAM1 | S1030 | ochoa | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| Q9Y597 | KCTD3 | S736 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y597 | KCTD3 | S738 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5B9 | SUPT16H | S986 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y5Q9 | GTF3C3 | S61 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| Q9Y623 | MYH4 | S952 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6D5 | ARFGEF2 | S1511 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6R1 | SLC4A4 | S61 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| R4GMW8 | BIVM-ERCC5 | S1013 | ochoa | DNA excision repair protein ERCC-5 | None |
| R4GMW8 | BIVM-ERCC5 | S1151 | ochoa | DNA excision repair protein ERCC-5 | None |
| R4GMW8 | BIVM-ERCC5 | S1153 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q01518 | CAP1 | S338 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q02818 | NUCB1 | S193 | Sugiyama | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q92888 | ARHGEF1 | S409 | Sugiyama | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q9NPQ8 | RIC8A | S452 | Sugiyama | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| O76021 | RSL1D1 | S314 | Sugiyama | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O95218 | ZRANB2 | Y167 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O94806 | PRKD3 | S376 | Sugiyama | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| P31153 | MAT2A | S38 | Sugiyama | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
| O60829 | PAGE4 | S73 | EPSD|PSP | P antigen family member 4 (PAGE-4) (G antigen family C member 1) (PAGE-1) | Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679). {ECO:0000269|PubMed:21357425, ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:25374899, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:30658679}. |
| Q32MK0 | MYLK3 | S429 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| P80303 | NUCB2 | S257 | Sugiyama | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| O00566 | MPHOSPH10 | T332 | EPSD|PSP | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| Q9H4A3 | WNK1 | S198 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| O43815 | STRN | S301 | Sugiyama | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000011 | 4.952 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000013 | 4.900 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000042 | 4.380 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.001338 | 2.874 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000624 | 3.205 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000691 | 3.160 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000691 | 3.160 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000839 | 3.076 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000839 | 3.076 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000921 | 3.036 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000921 | 3.036 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001102 | 2.958 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000428 | 3.368 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.001405 | 2.852 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.001306 | 2.884 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000921 | 3.036 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.001009 | 2.996 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.001659 | 2.780 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.001659 | 2.780 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.001790 | 2.747 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.001417 | 2.849 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.001534 | 2.814 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001783 | 2.749 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001783 | 2.749 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.002555 | 2.593 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.002731 | 2.564 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.003413 | 2.467 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.003413 | 2.467 |
| R-HSA-525793 | Myogenesis | 0.004931 | 2.307 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.005169 | 2.287 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.005244 | 2.280 |
| R-HSA-191859 | snRNP Assembly | 0.005825 | 2.235 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.005825 | 2.235 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.006800 | 2.167 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.006448 | 2.191 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.006554 | 2.184 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.006775 | 2.169 |
| R-HSA-210990 | PECAM1 interactions | 0.009856 | 2.006 |
| R-HSA-8953854 | Metabolism of RNA | 0.009491 | 2.023 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.009632 | 2.016 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.011118 | 1.954 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.011001 | 1.959 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.010664 | 1.972 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.011118 | 1.954 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.011976 | 1.922 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.012062 | 1.919 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.012698 | 1.896 |
| R-HSA-68875 | Mitotic Prophase | 0.014403 | 1.842 |
| R-HSA-5619102 | SLC transporter disorders | 0.014342 | 1.843 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.014724 | 1.832 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.014826 | 1.829 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.017272 | 1.763 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.015852 | 1.800 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.016400 | 1.785 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.016142 | 1.792 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.017541 | 1.756 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.020894 | 1.680 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.020894 | 1.680 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.020894 | 1.680 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.020894 | 1.680 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.020894 | 1.680 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.020042 | 1.698 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.021137 | 1.675 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.025011 | 1.602 |
| R-HSA-72649 | Translation initiation complex formation | 0.028556 | 1.544 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.027049 | 1.568 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.028208 | 1.550 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.029080 | 1.536 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.028317 | 1.548 |
| R-HSA-70171 | Glycolysis | 0.030852 | 1.511 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.028208 | 1.550 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.030940 | 1.509 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.030940 | 1.509 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 0.031178 | 1.506 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.031178 | 1.506 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 0.031178 | 1.506 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.035828 | 1.446 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.035828 | 1.446 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.035828 | 1.446 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.033425 | 1.476 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.033542 | 1.474 |
| R-HSA-73887 | Death Receptor Signaling | 0.036698 | 1.435 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.032614 | 1.487 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.038173 | 1.418 |
| R-HSA-211000 | Gene Silencing by RNA | 0.038250 | 1.417 |
| R-HSA-162587 | HIV Life Cycle | 0.039041 | 1.408 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.045544 | 1.342 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.040575 | 1.392 |
| R-HSA-9839394 | TGFBR3 expression | 0.043032 | 1.366 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.044857 | 1.348 |
| R-HSA-162906 | HIV Infection | 0.048230 | 1.317 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.043346 | 1.363 |
| R-HSA-1640170 | Cell Cycle | 0.046229 | 1.335 |
| R-HSA-74160 | Gene expression (Transcription) | 0.044964 | 1.347 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.050428 | 1.297 |
| R-HSA-70326 | Glucose metabolism | 0.051093 | 1.292 |
| R-HSA-72306 | tRNA processing | 0.051166 | 1.291 |
| R-HSA-73886 | Chromosome Maintenance | 0.055838 | 1.253 |
| R-HSA-3371556 | Cellular response to heat stress | 0.055838 | 1.253 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.056104 | 1.251 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.058297 | 1.234 |
| R-HSA-74713 | IRS activation | 0.071250 | 1.147 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.081007 | 1.091 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.100218 | 0.999 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.100218 | 0.999 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.119030 | 0.924 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.164366 | 0.784 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.173151 | 0.762 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.173151 | 0.762 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.173151 | 0.762 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.181844 | 0.740 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.070364 | 1.153 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.207382 | 0.683 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.215717 | 0.666 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.232127 | 0.634 |
| R-HSA-774815 | Nucleosome assembly | 0.108528 | 0.964 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.108528 | 0.964 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.248196 | 0.605 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.248196 | 0.605 |
| R-HSA-72187 | mRNA 3'-end processing | 0.132794 | 0.877 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.279337 | 0.554 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.279337 | 0.554 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.154464 | 0.811 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.294423 | 0.531 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.294423 | 0.531 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.294423 | 0.531 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.161833 | 0.791 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.176753 | 0.753 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.109399 | 0.961 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.189289 | 0.723 |
| R-HSA-72172 | mRNA Splicing | 0.213019 | 0.672 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.181844 | 0.740 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.256104 | 0.592 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.076365 | 1.117 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.109674 | 0.960 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.294423 | 0.531 |
| R-HSA-4641265 | Repression of WNT target genes | 0.155488 | 0.808 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.154464 | 0.811 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.140953 | 0.851 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.085656 | 1.067 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.240204 | 0.619 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.071250 | 1.147 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.118371 | 0.927 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.092029 | 1.036 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.136355 | 0.865 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.242291 | 0.616 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.109674 | 0.960 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.146517 | 0.834 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.181844 | 0.740 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.190446 | 0.720 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.215717 | 0.666 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.132794 | 0.877 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.271674 | 0.566 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.271674 | 0.566 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.136355 | 0.865 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.165541 | 0.781 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.102852 | 0.988 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.195687 | 0.708 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.214860 | 0.668 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.218716 | 0.660 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.232127 | 0.634 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.115334 | 0.938 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.176729 | 0.753 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.159266 | 0.798 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.159266 | 0.798 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.083793 | 1.077 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.280894 | 0.551 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.253634 | 0.596 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.109674 | 0.960 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.109674 | 0.960 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.215717 | 0.666 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.240204 | 0.619 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.271674 | 0.566 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.271674 | 0.566 |
| R-HSA-420029 | Tight junction interactions | 0.279337 | 0.554 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.134699 | 0.871 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.134699 | 0.871 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.286920 | 0.542 |
| R-HSA-9664873 | Pexophagy | 0.128289 | 0.892 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.118777 | 0.925 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.095266 | 1.021 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.120699 | 0.918 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.119030 | 0.924 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.173151 | 0.762 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.095266 | 1.021 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.177217 | 0.751 |
| R-HSA-4839726 | Chromatin organization | 0.157024 | 0.804 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.108522 | 0.964 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.064528 | 1.190 |
| R-HSA-72312 | rRNA processing | 0.276597 | 0.558 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.071250 | 1.147 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.100218 | 0.999 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.100218 | 0.999 |
| R-HSA-425381 | Bicarbonate transporters | 0.137451 | 0.862 |
| R-HSA-69091 | Polymerase switching | 0.155488 | 0.808 |
| R-HSA-69109 | Leading Strand Synthesis | 0.155488 | 0.808 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.155488 | 0.808 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.155488 | 0.808 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.132794 | 0.877 |
| R-HSA-429947 | Deadenylation of mRNA | 0.271674 | 0.566 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.279337 | 0.554 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.286920 | 0.542 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.238079 | 0.623 |
| R-HSA-68882 | Mitotic Anaphase | 0.106199 | 0.974 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.107601 | 0.968 |
| R-HSA-68877 | Mitotic Prometaphase | 0.075376 | 1.123 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.294423 | 0.531 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.108528 | 0.964 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.207167 | 0.684 |
| R-HSA-73894 | DNA Repair | 0.214829 | 0.668 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.071250 | 1.147 |
| R-HSA-448706 | Interleukin-1 processing | 0.119030 | 0.924 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.207382 | 0.683 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.256104 | 0.592 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.063678 | 1.196 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.198375 | 0.703 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.215717 | 0.666 |
| R-HSA-68886 | M Phase | 0.065278 | 1.185 |
| R-HSA-201451 | Signaling by BMP | 0.294423 | 0.531 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.279337 | 0.554 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.184293 | 0.734 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.188080 | 0.726 |
| R-HSA-9609690 | HCMV Early Events | 0.193539 | 0.713 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.118777 | 0.925 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.118777 | 0.925 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.232127 | 0.634 |
| R-HSA-156581 | Methylation | 0.105168 | 0.978 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.248196 | 0.605 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.263930 | 0.579 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.071250 | 1.147 |
| R-HSA-74749 | Signal attenuation | 0.128289 | 0.892 |
| R-HSA-9635465 | Suppression of apoptosis | 0.137451 | 0.862 |
| R-HSA-3295583 | TRP channels | 0.286920 | 0.542 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.111942 | 0.951 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.092029 | 1.036 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.168916 | 0.772 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.149277 | 0.826 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.173002 | 0.762 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.207167 | 0.684 |
| R-HSA-8852135 | Protein ubiquitination | 0.218716 | 0.660 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.264828 | 0.577 |
| R-HSA-3214842 | HDMs demethylate histones | 0.279337 | 0.554 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.132796 | 0.877 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.265317 | 0.576 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.155488 | 0.808 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.207382 | 0.683 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.215717 | 0.666 |
| R-HSA-5693538 | Homology Directed Repair | 0.164336 | 0.784 |
| R-HSA-9610379 | HCMV Late Events | 0.115409 | 0.938 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.214860 | 0.668 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.173151 | 0.762 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.207382 | 0.683 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.286920 | 0.542 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.199505 | 0.700 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.146700 | 0.834 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.146700 | 0.834 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.082522 | 1.083 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.161833 | 0.791 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.164336 | 0.784 |
| R-HSA-397014 | Muscle contraction | 0.100682 | 0.997 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.134699 | 0.871 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.223965 | 0.650 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.111917 | 0.951 |
| R-HSA-168255 | Influenza Infection | 0.158461 | 0.800 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.215717 | 0.666 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.279337 | 0.554 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.193539 | 0.713 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.128289 | 0.892 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.223965 | 0.650 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.256104 | 0.592 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.263930 | 0.579 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.151754 | 0.819 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.261995 | 0.582 |
| R-HSA-421270 | Cell-cell junction organization | 0.160386 | 0.795 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.240830 | 0.618 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.268824 | 0.571 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.170043 | 0.769 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.106830 | 0.971 |
| R-HSA-418990 | Adherens junctions interactions | 0.244330 | 0.612 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.118777 | 0.925 |
| R-HSA-446728 | Cell junction organization | 0.208424 | 0.681 |
| R-HSA-1500931 | Cell-Cell communication | 0.146605 | 0.834 |
| R-HSA-5358508 | Mismatch Repair | 0.215717 | 0.666 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.070364 | 1.153 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.223965 | 0.650 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.263930 | 0.579 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.123617 | 0.908 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.132794 | 0.877 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.080294 | 1.095 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.092308 | 1.035 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.065141 | 1.186 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.088825 | 1.051 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.290470 | 0.537 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.228377 | 0.641 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.196801 | 0.706 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.110226 | 0.958 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.296447 | 0.528 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.296800 | 0.528 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.300329 | 0.522 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.301848 | 0.520 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.301848 | 0.520 |
| R-HSA-77387 | Insulin receptor recycling | 0.301848 | 0.520 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.301848 | 0.520 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.301848 | 0.520 |
| R-HSA-622312 | Inflammasomes | 0.301848 | 0.520 |
| R-HSA-2262752 | Cellular responses to stress | 0.304034 | 0.517 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.309196 | 0.510 |
| R-HSA-157579 | Telomere Maintenance | 0.315817 | 0.501 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.316466 | 0.500 |
| R-HSA-2424491 | DAP12 signaling | 0.316466 | 0.500 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.316466 | 0.500 |
| R-HSA-9609646 | HCMV Infection | 0.319005 | 0.496 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.323660 | 0.490 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.323660 | 0.490 |
| R-HSA-69190 | DNA strand elongation | 0.330779 | 0.480 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.330779 | 0.480 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.330779 | 0.480 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.331228 | 0.480 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.331228 | 0.480 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.335961 | 0.474 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.337824 | 0.471 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.337824 | 0.471 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.337824 | 0.471 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.337824 | 0.471 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.342724 | 0.465 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.344795 | 0.462 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.344795 | 0.462 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.344795 | 0.462 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.348612 | 0.458 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.350354 | 0.455 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.351693 | 0.454 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.351693 | 0.454 |
| R-HSA-5205647 | Mitophagy | 0.351693 | 0.454 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.358518 | 0.445 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.358518 | 0.445 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.358518 | 0.445 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.358518 | 0.445 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.365273 | 0.437 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.365273 | 0.437 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.365273 | 0.437 |
| R-HSA-8853659 | RET signaling | 0.365273 | 0.437 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.371956 | 0.430 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.376212 | 0.425 |
| R-HSA-983712 | Ion channel transport | 0.376516 | 0.424 |
| R-HSA-69541 | Stabilization of p53 | 0.385114 | 0.414 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.385114 | 0.414 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.385114 | 0.414 |
| R-HSA-201556 | Signaling by ALK | 0.385114 | 0.414 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.391590 | 0.407 |
| R-HSA-202433 | Generation of second messenger molecules | 0.391590 | 0.407 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.391590 | 0.407 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.391590 | 0.407 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.391590 | 0.407 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.391590 | 0.407 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.391590 | 0.407 |
| R-HSA-167169 | HIV Transcription Elongation | 0.391590 | 0.407 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.391590 | 0.407 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.391590 | 0.407 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.391590 | 0.407 |
| R-HSA-5260271 | Diseases of Immune System | 0.391590 | 0.407 |
| R-HSA-212436 | Generic Transcription Pathway | 0.396044 | 0.402 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.397998 | 0.400 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.397998 | 0.400 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.397998 | 0.400 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.397998 | 0.400 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.397998 | 0.400 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.404339 | 0.393 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.404339 | 0.393 |
| R-HSA-9679506 | SARS-CoV Infections | 0.406903 | 0.391 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.407702 | 0.390 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.410614 | 0.387 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.410614 | 0.387 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.416822 | 0.380 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.417449 | 0.379 |
| R-HSA-2172127 | DAP12 interactions | 0.422966 | 0.374 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.422966 | 0.374 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.422966 | 0.374 |
| R-HSA-913531 | Interferon Signaling | 0.423444 | 0.373 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.429046 | 0.367 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.429046 | 0.367 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.435061 | 0.361 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.435061 | 0.361 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.435061 | 0.361 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.435061 | 0.361 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.435061 | 0.361 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.441014 | 0.356 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.441014 | 0.356 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.446159 | 0.351 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.446697 | 0.350 |
| R-HSA-9766229 | Degradation of CDH1 | 0.452733 | 0.344 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.452733 | 0.344 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.452733 | 0.344 |
| R-HSA-73893 | DNA Damage Bypass | 0.452733 | 0.344 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.463702 | 0.334 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.464208 | 0.333 |
| R-HSA-2514856 | The phototransduction cascade | 0.464208 | 0.333 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.469855 | 0.328 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.475444 | 0.323 |
| R-HSA-1221632 | Meiotic synapsis | 0.475444 | 0.323 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.480917 | 0.318 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.484319 | 0.315 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.486445 | 0.313 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.486445 | 0.313 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.490667 | 0.309 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.491859 | 0.308 |
| R-HSA-5578775 | Ion homeostasis | 0.491859 | 0.308 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.494444 | 0.306 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.494444 | 0.306 |
| R-HSA-9664407 | Parasite infection | 0.494444 | 0.306 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.497217 | 0.303 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.497217 | 0.303 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.505800 | 0.296 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.507764 | 0.294 |
| R-HSA-9033241 | Peroxisomal protein import | 0.507764 | 0.294 |
| R-HSA-180786 | Extension of Telomeres | 0.507764 | 0.294 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.507764 | 0.294 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.507764 | 0.294 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.512955 | 0.290 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.512955 | 0.290 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.512955 | 0.290 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.516179 | 0.287 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.523174 | 0.281 |
| R-HSA-186797 | Signaling by PDGF | 0.523174 | 0.281 |
| R-HSA-166520 | Signaling by NTRKs | 0.524056 | 0.281 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.528203 | 0.277 |
| R-HSA-8848021 | Signaling by PTK6 | 0.528203 | 0.277 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.528203 | 0.277 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.533180 | 0.273 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.533180 | 0.273 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.536841 | 0.270 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.542977 | 0.265 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.547799 | 0.261 |
| R-HSA-196807 | Nicotinate metabolism | 0.547799 | 0.261 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.547799 | 0.261 |
| R-HSA-167172 | Transcription of the HIV genome | 0.552570 | 0.258 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.552570 | 0.258 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.552570 | 0.258 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.555575 | 0.255 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.561962 | 0.250 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.561962 | 0.250 |
| R-HSA-199991 | Membrane Trafficking | 0.562921 | 0.250 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.566585 | 0.247 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.566585 | 0.247 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.571159 | 0.243 |
| R-HSA-4086398 | Ca2+ pathway | 0.575685 | 0.240 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.580163 | 0.236 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.587882 | 0.231 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.588980 | 0.230 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.593319 | 0.227 |
| R-HSA-4086400 | PCP/CE pathway | 0.597612 | 0.224 |
| R-HSA-216083 | Integrin cell surface interactions | 0.597612 | 0.224 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.597612 | 0.224 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.600041 | 0.222 |
| R-HSA-9659379 | Sensory processing of sound | 0.601860 | 0.221 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.602885 | 0.220 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.605713 | 0.218 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.606064 | 0.217 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.610224 | 0.215 |
| R-HSA-9658195 | Leishmania infection | 0.617755 | 0.209 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.617755 | 0.209 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.618413 | 0.209 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.622443 | 0.206 |
| R-HSA-1500620 | Meiosis | 0.626430 | 0.203 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.626430 | 0.203 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.630484 | 0.200 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.638144 | 0.195 |
| R-HSA-9663891 | Selective autophagy | 0.641967 | 0.192 |
| R-HSA-73884 | Base Excision Repair | 0.649492 | 0.187 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.653196 | 0.185 |
| R-HSA-195721 | Signaling by WNT | 0.654576 | 0.184 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.660487 | 0.180 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.660487 | 0.180 |
| R-HSA-391251 | Protein folding | 0.660487 | 0.180 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.660487 | 0.180 |
| R-HSA-2029481 | FCGR activation | 0.664075 | 0.178 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.671139 | 0.173 |
| R-HSA-9824446 | Viral Infection Pathways | 0.673268 | 0.172 |
| R-HSA-428157 | Sphingolipid metabolism | 0.676382 | 0.170 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.678054 | 0.169 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.678054 | 0.169 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.678054 | 0.169 |
| R-HSA-449147 | Signaling by Interleukins | 0.680703 | 0.167 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.684826 | 0.164 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.684826 | 0.164 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.684826 | 0.164 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.697946 | 0.156 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.697946 | 0.156 |
| R-HSA-1483255 | PI Metabolism | 0.697946 | 0.156 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.704347 | 0.152 |
| R-HSA-9833110 | RSV-host interactions | 0.707429 | 0.150 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.710524 | 0.148 |
| R-HSA-418346 | Platelet homeostasis | 0.713586 | 0.147 |
| R-HSA-69239 | Synthesis of DNA | 0.716616 | 0.145 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.719614 | 0.143 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.722581 | 0.141 |
| R-HSA-202403 | TCR signaling | 0.725516 | 0.139 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.725516 | 0.139 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.725516 | 0.139 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.725814 | 0.139 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.731294 | 0.136 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.734138 | 0.134 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.734138 | 0.134 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.734416 | 0.134 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.736952 | 0.133 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.742491 | 0.129 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.742704 | 0.129 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.745217 | 0.128 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.745217 | 0.128 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.750583 | 0.125 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.755836 | 0.122 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.755836 | 0.122 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.755836 | 0.122 |
| R-HSA-8939211 | ESR-mediated signaling | 0.756193 | 0.121 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.756193 | 0.121 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.760980 | 0.119 |
| R-HSA-112316 | Neuronal System | 0.761405 | 0.118 |
| R-HSA-162582 | Signal Transduction | 0.761822 | 0.118 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.763511 | 0.117 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.763511 | 0.117 |
| R-HSA-1643685 | Disease | 0.763850 | 0.117 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.766016 | 0.116 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.775773 | 0.110 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.776831 | 0.110 |
| R-HSA-114608 | Platelet degranulation | 0.778149 | 0.109 |
| R-HSA-69481 | G2/M Checkpoints | 0.778149 | 0.109 |
| R-HSA-1474165 | Reproduction | 0.787403 | 0.104 |
| R-HSA-597592 | Post-translational protein modification | 0.788378 | 0.103 |
| R-HSA-5688426 | Deubiquitination | 0.788521 | 0.103 |
| R-HSA-9843745 | Adipogenesis | 0.789656 | 0.103 |
| R-HSA-5576891 | Cardiac conduction | 0.789656 | 0.103 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.791885 | 0.101 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.794091 | 0.100 |
| R-HSA-1280218 | Adaptive Immune System | 0.799837 | 0.097 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.801644 | 0.096 |
| R-HSA-6807070 | PTEN Regulation | 0.808894 | 0.092 |
| R-HSA-5663205 | Infectious disease | 0.811391 | 0.091 |
| R-HSA-1632852 | Macroautophagy | 0.812926 | 0.090 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.812926 | 0.090 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.820108 | 0.086 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.826382 | 0.083 |
| R-HSA-2187338 | Visual phototransduction | 0.826382 | 0.083 |
| R-HSA-69242 | S Phase | 0.828224 | 0.082 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.828224 | 0.082 |
| R-HSA-9758941 | Gastrulation | 0.830047 | 0.081 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.831850 | 0.080 |
| R-HSA-9609507 | Protein localization | 0.837147 | 0.077 |
| R-HSA-69306 | DNA Replication | 0.837147 | 0.077 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.838875 | 0.076 |
| R-HSA-9612973 | Autophagy | 0.842278 | 0.075 |
| R-HSA-9711097 | Cellular response to starvation | 0.845609 | 0.073 |
| R-HSA-1483257 | Phospholipid metabolism | 0.847208 | 0.072 |
| R-HSA-877300 | Interferon gamma signaling | 0.847248 | 0.072 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.855188 | 0.068 |
| R-HSA-72766 | Translation | 0.856495 | 0.067 |
| R-HSA-109582 | Hemostasis | 0.856976 | 0.067 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.867048 | 0.062 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.869858 | 0.061 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.869858 | 0.061 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.872610 | 0.059 |
| R-HSA-2559583 | Cellular Senescence | 0.879239 | 0.056 |
| R-HSA-6798695 | Neutrophil degranulation | 0.882918 | 0.054 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.892639 | 0.049 |
| R-HSA-1266738 | Developmental Biology | 0.895215 | 0.048 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.904561 | 0.044 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.905577 | 0.043 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.905577 | 0.043 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.905577 | 0.043 |
| R-HSA-392499 | Metabolism of proteins | 0.909959 | 0.041 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.914119 | 0.039 |
| R-HSA-8951664 | Neddylation | 0.922964 | 0.035 |
| R-HSA-211859 | Biological oxidations | 0.928883 | 0.032 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.929295 | 0.032 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.930049 | 0.031 |
| R-HSA-157118 | Signaling by NOTCH | 0.937164 | 0.028 |
| R-HSA-422475 | Axon guidance | 0.940090 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 0.951440 | 0.022 |
| R-HSA-168249 | Innate Immune System | 0.952361 | 0.021 |
| R-HSA-9675108 | Nervous system development | 0.955341 | 0.020 |
| R-HSA-382551 | Transport of small molecules | 0.956724 | 0.019 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.959985 | 0.018 |
| R-HSA-388396 | GPCR downstream signalling | 0.970523 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.976400 | 0.010 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.983477 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 0.984559 | 0.007 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.986693 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.987665 | 0.005 |
| R-HSA-168256 | Immune System | 0.990190 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.991281 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998975 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999942 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999985 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.854 | 0.284 | 2 | 0.840 |
CLK3 |
0.842 | 0.213 | 1 | 0.774 |
MOS |
0.838 | 0.253 | 1 | 0.876 |
DSTYK |
0.837 | 0.172 | 2 | 0.844 |
CDC7 |
0.835 | 0.136 | 1 | 0.865 |
BMPR1B |
0.834 | 0.322 | 1 | 0.786 |
CAMK2G |
0.831 | 0.109 | 2 | 0.820 |
GRK1 |
0.829 | 0.170 | -2 | 0.761 |
GCN2 |
0.828 | 0.027 | 2 | 0.774 |
PIM3 |
0.827 | 0.032 | -3 | 0.702 |
PRPK |
0.827 | -0.026 | -1 | 0.861 |
NDR2 |
0.827 | 0.028 | -3 | 0.710 |
FAM20C |
0.827 | 0.115 | 2 | 0.565 |
TGFBR2 |
0.826 | 0.135 | -2 | 0.893 |
RAF1 |
0.825 | 0.008 | 1 | 0.817 |
BMPR2 |
0.825 | 0.146 | -2 | 0.873 |
IKKA |
0.824 | 0.124 | -2 | 0.693 |
BMPR1A |
0.824 | 0.342 | 1 | 0.787 |
NEK6 |
0.824 | 0.056 | -2 | 0.869 |
TGFBR1 |
0.824 | 0.262 | -2 | 0.871 |
GRK6 |
0.824 | 0.161 | 1 | 0.802 |
IKKB |
0.823 | -0.015 | -2 | 0.701 |
ALK2 |
0.822 | 0.311 | -2 | 0.871 |
ACVR2B |
0.821 | 0.280 | -2 | 0.879 |
ACVR2A |
0.821 | 0.260 | -2 | 0.879 |
TBK1 |
0.820 | -0.004 | 1 | 0.717 |
PLK3 |
0.820 | 0.232 | 2 | 0.754 |
CAMK1B |
0.819 | -0.031 | -3 | 0.720 |
ALK4 |
0.819 | 0.215 | -2 | 0.884 |
PIM1 |
0.819 | 0.049 | -3 | 0.637 |
GRK5 |
0.819 | 0.003 | -3 | 0.763 |
NEK7 |
0.818 | -0.028 | -3 | 0.727 |
KIS |
0.818 | 0.058 | 1 | 0.618 |
IKKE |
0.818 | -0.007 | 1 | 0.718 |
GRK4 |
0.818 | 0.083 | -2 | 0.820 |
RSK2 |
0.818 | 0.018 | -3 | 0.626 |
GRK7 |
0.818 | 0.195 | 1 | 0.705 |
PKN3 |
0.818 | -0.012 | -3 | 0.677 |
LATS1 |
0.818 | 0.143 | -3 | 0.744 |
PLK1 |
0.817 | 0.170 | -2 | 0.872 |
PDHK4 |
0.817 | -0.211 | 1 | 0.808 |
LATS2 |
0.817 | 0.018 | -5 | 0.688 |
MTOR |
0.817 | -0.099 | 1 | 0.712 |
CAMK2B |
0.817 | 0.112 | 2 | 0.780 |
ULK2 |
0.816 | -0.124 | 2 | 0.749 |
ATM |
0.816 | 0.072 | 1 | 0.732 |
MST4 |
0.815 | 0.022 | 2 | 0.833 |
PKCD |
0.815 | 0.044 | 2 | 0.775 |
MLK1 |
0.815 | 0.002 | 2 | 0.786 |
ATR |
0.814 | -0.046 | 1 | 0.780 |
PDHK1 |
0.813 | -0.156 | 1 | 0.813 |
NDR1 |
0.813 | -0.047 | -3 | 0.695 |
NIK |
0.812 | -0.070 | -3 | 0.749 |
PRKD1 |
0.812 | -0.026 | -3 | 0.655 |
CAMK2A |
0.812 | 0.080 | 2 | 0.809 |
CDKL1 |
0.811 | -0.061 | -3 | 0.654 |
SKMLCK |
0.811 | -0.024 | -2 | 0.811 |
SRPK1 |
0.811 | 0.001 | -3 | 0.599 |
CHAK2 |
0.809 | -0.022 | -1 | 0.857 |
NLK |
0.809 | -0.102 | 1 | 0.753 |
PLK2 |
0.809 | 0.325 | -3 | 0.902 |
ULK1 |
0.809 | -0.124 | -3 | 0.695 |
CAMLCK |
0.809 | -0.049 | -2 | 0.815 |
CAMK2D |
0.808 | -0.046 | -3 | 0.680 |
CK2A2 |
0.808 | 0.240 | 1 | 0.744 |
P90RSK |
0.808 | -0.041 | -3 | 0.627 |
PRKD2 |
0.808 | -0.015 | -3 | 0.607 |
MLK3 |
0.808 | 0.046 | 2 | 0.734 |
MAPKAPK2 |
0.808 | -0.009 | -3 | 0.585 |
MLK4 |
0.807 | 0.088 | 2 | 0.705 |
CLK2 |
0.807 | 0.102 | -3 | 0.616 |
SRPK2 |
0.807 | 0.003 | -3 | 0.537 |
TLK2 |
0.806 | 0.114 | 1 | 0.753 |
RSK3 |
0.806 | -0.047 | -3 | 0.636 |
ERK5 |
0.806 | -0.079 | 1 | 0.722 |
P70S6KB |
0.806 | -0.040 | -3 | 0.653 |
WNK1 |
0.806 | -0.110 | -2 | 0.794 |
DAPK2 |
0.806 | -0.080 | -3 | 0.724 |
AURC |
0.806 | 0.041 | -2 | 0.670 |
PKN2 |
0.806 | -0.064 | -3 | 0.681 |
PRKX |
0.805 | 0.087 | -3 | 0.543 |
RIPK3 |
0.805 | -0.134 | 3 | 0.757 |
HUNK |
0.805 | -0.136 | 2 | 0.764 |
ANKRD3 |
0.805 | -0.059 | 1 | 0.806 |
NUAK2 |
0.805 | -0.082 | -3 | 0.688 |
BCKDK |
0.805 | -0.140 | -1 | 0.810 |
PKACG |
0.805 | -0.016 | -2 | 0.737 |
RSK4 |
0.804 | 0.020 | -3 | 0.601 |
MARK4 |
0.804 | -0.106 | 4 | 0.735 |
PKR |
0.804 | 0.034 | 1 | 0.801 |
TTBK2 |
0.803 | -0.097 | 2 | 0.701 |
PKACB |
0.803 | 0.043 | -2 | 0.687 |
AMPKA1 |
0.803 | -0.089 | -3 | 0.699 |
DLK |
0.802 | -0.111 | 1 | 0.774 |
CLK4 |
0.802 | 0.023 | -3 | 0.624 |
NEK9 |
0.802 | -0.155 | 2 | 0.799 |
IRE2 |
0.802 | -0.010 | 2 | 0.732 |
TSSK2 |
0.801 | -0.044 | -5 | 0.738 |
ICK |
0.800 | -0.074 | -3 | 0.678 |
CDKL5 |
0.800 | -0.081 | -3 | 0.632 |
MAPKAPK3 |
0.800 | -0.106 | -3 | 0.620 |
PAK1 |
0.800 | -0.027 | -2 | 0.736 |
TSSK1 |
0.800 | -0.036 | -3 | 0.717 |
YSK4 |
0.799 | -0.021 | 1 | 0.734 |
CLK1 |
0.799 | 0.021 | -3 | 0.597 |
MSK2 |
0.799 | -0.052 | -3 | 0.598 |
SRPK3 |
0.799 | -0.016 | -3 | 0.591 |
TLK1 |
0.799 | 0.087 | -2 | 0.870 |
AURA |
0.799 | 0.046 | -2 | 0.644 |
PKCB |
0.798 | -0.017 | 2 | 0.725 |
PERK |
0.798 | 0.036 | -2 | 0.866 |
WNK3 |
0.798 | -0.247 | 1 | 0.772 |
GSK3A |
0.798 | 0.150 | 4 | 0.574 |
MSK1 |
0.798 | 0.003 | -3 | 0.603 |
MASTL |
0.798 | -0.293 | -2 | 0.757 |
CDK1 |
0.797 | 0.032 | 1 | 0.540 |
AURB |
0.796 | 0.015 | -2 | 0.664 |
GRK2 |
0.796 | 0.009 | -2 | 0.712 |
BRAF |
0.796 | 0.034 | -4 | 0.803 |
CAMK4 |
0.796 | -0.113 | -3 | 0.675 |
IRE1 |
0.796 | -0.111 | 1 | 0.739 |
AMPKA2 |
0.796 | -0.092 | -3 | 0.666 |
DNAPK |
0.796 | 0.016 | 1 | 0.671 |
MEK1 |
0.795 | -0.114 | 2 | 0.796 |
PKCG |
0.795 | -0.045 | 2 | 0.731 |
CDK8 |
0.795 | -0.051 | 1 | 0.587 |
CK2A1 |
0.795 | 0.198 | 1 | 0.716 |
PRKD3 |
0.795 | -0.057 | -3 | 0.597 |
MLK2 |
0.794 | -0.186 | 2 | 0.777 |
HRI |
0.794 | -0.032 | -2 | 0.868 |
PKCA |
0.794 | -0.033 | 2 | 0.713 |
NUAK1 |
0.794 | -0.083 | -3 | 0.655 |
CHK1 |
0.794 | -0.035 | -3 | 0.712 |
MNK2 |
0.794 | -0.042 | -2 | 0.763 |
GSK3B |
0.793 | 0.107 | 4 | 0.561 |
HIPK4 |
0.793 | -0.110 | 1 | 0.717 |
MNK1 |
0.793 | -0.023 | -2 | 0.778 |
PKCH |
0.792 | -0.045 | 2 | 0.703 |
PAK3 |
0.792 | -0.099 | -2 | 0.730 |
NEK2 |
0.791 | -0.138 | 2 | 0.773 |
NIM1 |
0.791 | -0.157 | 3 | 0.786 |
JNK3 |
0.790 | -0.003 | 1 | 0.571 |
CDK5 |
0.790 | -0.002 | 1 | 0.610 |
VRK2 |
0.790 | -0.245 | 1 | 0.816 |
AKT2 |
0.790 | -0.025 | -3 | 0.543 |
MELK |
0.789 | -0.121 | -3 | 0.648 |
CHAK1 |
0.789 | -0.118 | 2 | 0.711 |
JNK2 |
0.789 | -0.001 | 1 | 0.537 |
PKCZ |
0.789 | -0.083 | 2 | 0.746 |
PKG2 |
0.788 | -0.018 | -2 | 0.687 |
MEKK3 |
0.788 | -0.069 | 1 | 0.745 |
MYLK4 |
0.788 | -0.063 | -2 | 0.746 |
RIPK1 |
0.788 | -0.294 | 1 | 0.753 |
MEKK2 |
0.788 | -0.008 | 2 | 0.767 |
PIM2 |
0.787 | -0.046 | -3 | 0.596 |
CDK19 |
0.787 | -0.059 | 1 | 0.549 |
PKACA |
0.787 | 0.017 | -2 | 0.645 |
SGK3 |
0.787 | -0.045 | -3 | 0.608 |
CDK2 |
0.787 | -0.010 | 1 | 0.616 |
MEKK1 |
0.787 | -0.082 | 1 | 0.771 |
DCAMKL1 |
0.787 | -0.052 | -3 | 0.647 |
PINK1 |
0.786 | -0.107 | 1 | 0.759 |
GRK3 |
0.786 | 0.023 | -2 | 0.681 |
SIK |
0.786 | -0.110 | -3 | 0.630 |
PAK6 |
0.786 | -0.020 | -2 | 0.665 |
PASK |
0.786 | 0.011 | -3 | 0.712 |
DRAK1 |
0.786 | -0.096 | 1 | 0.679 |
PAK2 |
0.785 | -0.095 | -2 | 0.723 |
QSK |
0.785 | -0.119 | 4 | 0.704 |
PLK4 |
0.785 | -0.087 | 2 | 0.600 |
PHKG1 |
0.785 | -0.134 | -3 | 0.680 |
TAO3 |
0.785 | -0.003 | 1 | 0.739 |
MARK3 |
0.785 | -0.091 | 4 | 0.680 |
CDK3 |
0.784 | 0.042 | 1 | 0.484 |
DYRK2 |
0.784 | -0.072 | 1 | 0.619 |
MST2 |
0.784 | 0.078 | 1 | 0.772 |
ZAK |
0.784 | -0.092 | 1 | 0.734 |
SMG1 |
0.784 | -0.119 | 1 | 0.733 |
CAMK1G |
0.783 | -0.092 | -3 | 0.611 |
MARK2 |
0.783 | -0.102 | 4 | 0.632 |
NEK5 |
0.782 | -0.123 | 1 | 0.775 |
CDK13 |
0.782 | -0.072 | 1 | 0.566 |
BRSK1 |
0.782 | -0.134 | -3 | 0.655 |
QIK |
0.782 | -0.213 | -3 | 0.685 |
GAK |
0.781 | 0.045 | 1 | 0.792 |
CDK7 |
0.781 | -0.105 | 1 | 0.597 |
P38A |
0.781 | -0.056 | 1 | 0.614 |
CK1E |
0.781 | -0.072 | -3 | 0.479 |
P38G |
0.781 | -0.019 | 1 | 0.456 |
CDK18 |
0.780 | -0.047 | 1 | 0.518 |
DCAMKL2 |
0.780 | -0.064 | -3 | 0.667 |
MEK5 |
0.780 | -0.242 | 2 | 0.779 |
MST3 |
0.780 | -0.062 | 2 | 0.808 |
ERK1 |
0.779 | -0.040 | 1 | 0.537 |
EEF2K |
0.779 | 0.054 | 3 | 0.854 |
ERK2 |
0.779 | -0.059 | 1 | 0.573 |
PRP4 |
0.779 | -0.074 | -3 | 0.630 |
SMMLCK |
0.778 | -0.085 | -3 | 0.663 |
CAMK1D |
0.778 | -0.051 | -3 | 0.555 |
CK1G1 |
0.778 | -0.070 | -3 | 0.510 |
AKT1 |
0.778 | -0.029 | -3 | 0.555 |
MARK1 |
0.777 | -0.133 | 4 | 0.697 |
PKCT |
0.777 | -0.079 | 2 | 0.710 |
P38B |
0.777 | -0.044 | 1 | 0.545 |
CDK17 |
0.777 | -0.048 | 1 | 0.462 |
NEK8 |
0.776 | -0.103 | 2 | 0.784 |
TTK |
0.776 | 0.198 | -2 | 0.890 |
MAPKAPK5 |
0.776 | -0.191 | -3 | 0.569 |
HIPK2 |
0.776 | -0.042 | 1 | 0.531 |
CDK16 |
0.776 | -0.011 | 1 | 0.482 |
TNIK |
0.776 | 0.031 | 3 | 0.878 |
HIPK1 |
0.775 | -0.068 | 1 | 0.635 |
DAPK3 |
0.775 | -0.022 | -3 | 0.657 |
P70S6K |
0.774 | -0.099 | -3 | 0.563 |
CK1D |
0.774 | -0.068 | -3 | 0.422 |
MST1 |
0.774 | 0.025 | 1 | 0.754 |
TAO2 |
0.774 | -0.087 | 2 | 0.816 |
GCK |
0.774 | -0.021 | 1 | 0.754 |
CAMKK1 |
0.773 | -0.168 | -2 | 0.687 |
WNK4 |
0.773 | -0.207 | -2 | 0.773 |
BRSK2 |
0.773 | -0.206 | -3 | 0.666 |
IRAK4 |
0.773 | -0.185 | 1 | 0.757 |
TTBK1 |
0.773 | -0.148 | 2 | 0.633 |
P38D |
0.772 | -0.017 | 1 | 0.495 |
CDK12 |
0.772 | -0.082 | 1 | 0.537 |
PKCE |
0.772 | -0.024 | 2 | 0.713 |
DYRK1A |
0.772 | -0.091 | 1 | 0.656 |
DYRK4 |
0.771 | -0.044 | 1 | 0.545 |
PHKG2 |
0.771 | -0.120 | -3 | 0.648 |
SNRK |
0.771 | -0.270 | 2 | 0.645 |
HGK |
0.770 | -0.048 | 3 | 0.873 |
MINK |
0.770 | -0.046 | 1 | 0.761 |
PKCI |
0.770 | -0.088 | 2 | 0.724 |
SSTK |
0.769 | -0.108 | 4 | 0.682 |
CK1A2 |
0.769 | -0.080 | -3 | 0.419 |
TAK1 |
0.769 | -0.062 | 1 | 0.790 |
MRCKA |
0.769 | -0.011 | -3 | 0.615 |
PDHK3_TYR |
0.769 | 0.192 | 4 | 0.829 |
CAMKK2 |
0.769 | -0.179 | -2 | 0.682 |
DAPK1 |
0.768 | -0.031 | -3 | 0.634 |
CDK9 |
0.768 | -0.120 | 1 | 0.572 |
LKB1 |
0.768 | -0.190 | -3 | 0.700 |
CDK14 |
0.767 | -0.072 | 1 | 0.561 |
JNK1 |
0.767 | -0.021 | 1 | 0.522 |
SGK1 |
0.767 | -0.029 | -3 | 0.470 |
SLK |
0.766 | -0.050 | -2 | 0.687 |
AKT3 |
0.766 | -0.032 | -3 | 0.478 |
PAK5 |
0.765 | -0.066 | -2 | 0.608 |
NEK4 |
0.765 | -0.186 | 1 | 0.757 |
MPSK1 |
0.765 | -0.127 | 1 | 0.731 |
MRCKB |
0.765 | -0.032 | -3 | 0.589 |
CDK10 |
0.765 | -0.049 | 1 | 0.547 |
NEK11 |
0.764 | -0.243 | 1 | 0.735 |
DYRK3 |
0.764 | -0.076 | 1 | 0.642 |
ERK7 |
0.764 | -0.033 | 2 | 0.536 |
ALPHAK3 |
0.764 | 0.132 | -1 | 0.818 |
HIPK3 |
0.764 | -0.121 | 1 | 0.633 |
DYRK1B |
0.764 | -0.088 | 1 | 0.566 |
LOK |
0.764 | -0.086 | -2 | 0.731 |
ROCK2 |
0.763 | -0.025 | -3 | 0.637 |
PAK4 |
0.763 | -0.053 | -2 | 0.621 |
OSR1 |
0.762 | 0.032 | 2 | 0.755 |
CAMK1A |
0.761 | -0.071 | -3 | 0.513 |
HPK1 |
0.761 | -0.096 | 1 | 0.743 |
LRRK2 |
0.761 | -0.200 | 2 | 0.807 |
MAP2K6_TYR |
0.760 | 0.111 | -1 | 0.893 |
PDHK4_TYR |
0.760 | 0.087 | 2 | 0.837 |
KHS1 |
0.760 | -0.041 | 1 | 0.753 |
NEK1 |
0.760 | -0.182 | 1 | 0.754 |
KHS2 |
0.760 | -0.011 | 1 | 0.757 |
PKN1 |
0.760 | -0.106 | -3 | 0.567 |
DMPK1 |
0.759 | -0.000 | -3 | 0.610 |
IRAK1 |
0.759 | -0.316 | -1 | 0.751 |
PDK1 |
0.759 | -0.204 | 1 | 0.743 |
BUB1 |
0.758 | -0.005 | -5 | 0.712 |
PDHK1_TYR |
0.758 | 0.080 | -1 | 0.913 |
CHK2 |
0.758 | -0.098 | -3 | 0.490 |
EPHA6 |
0.757 | 0.116 | -1 | 0.885 |
BMPR2_TYR |
0.757 | 0.060 | -1 | 0.879 |
VRK1 |
0.757 | -0.223 | 2 | 0.799 |
MAP3K15 |
0.757 | -0.210 | 1 | 0.712 |
MAP2K4_TYR |
0.756 | -0.008 | -1 | 0.887 |
MEKK6 |
0.756 | -0.236 | 1 | 0.738 |
TESK1_TYR |
0.756 | -0.089 | 3 | 0.886 |
STK33 |
0.756 | -0.162 | 2 | 0.607 |
SBK |
0.756 | -0.070 | -3 | 0.431 |
CDK6 |
0.755 | -0.056 | 1 | 0.545 |
YSK1 |
0.754 | -0.128 | 2 | 0.778 |
MEK2 |
0.754 | -0.230 | 2 | 0.761 |
EPHB4 |
0.753 | 0.093 | -1 | 0.855 |
TXK |
0.753 | 0.180 | 1 | 0.812 |
PBK |
0.752 | -0.086 | 1 | 0.729 |
MAK |
0.752 | -0.052 | -2 | 0.661 |
MAP2K7_TYR |
0.752 | -0.171 | 2 | 0.819 |
PINK1_TYR |
0.751 | -0.088 | 1 | 0.775 |
ROCK1 |
0.751 | -0.039 | -3 | 0.605 |
EPHA4 |
0.750 | 0.106 | 2 | 0.753 |
CDK4 |
0.750 | -0.079 | 1 | 0.527 |
PKMYT1_TYR |
0.749 | -0.169 | 3 | 0.855 |
RET |
0.748 | -0.046 | 1 | 0.749 |
RIPK2 |
0.748 | -0.288 | 1 | 0.700 |
BLK |
0.748 | 0.159 | -1 | 0.837 |
PKG1 |
0.747 | -0.068 | -2 | 0.618 |
YES1 |
0.747 | 0.080 | -1 | 0.838 |
MYO3A |
0.747 | -0.044 | 1 | 0.746 |
FER |
0.747 | 0.056 | 1 | 0.846 |
SRMS |
0.746 | 0.087 | 1 | 0.826 |
EPHB2 |
0.746 | 0.119 | -1 | 0.837 |
INSRR |
0.746 | 0.058 | 3 | 0.761 |
LCK |
0.745 | 0.112 | -1 | 0.822 |
MYO3B |
0.745 | -0.086 | 2 | 0.794 |
FGR |
0.744 | -0.003 | 1 | 0.794 |
CRIK |
0.744 | -0.062 | -3 | 0.544 |
YANK3 |
0.744 | -0.060 | 2 | 0.431 |
ABL2 |
0.744 | 0.042 | -1 | 0.835 |
HASPIN |
0.744 | -0.060 | -1 | 0.692 |
BIKE |
0.743 | -0.023 | 1 | 0.680 |
TYRO3 |
0.743 | -0.076 | 3 | 0.810 |
EPHB1 |
0.743 | 0.047 | 1 | 0.815 |
TYK2 |
0.743 | -0.120 | 1 | 0.757 |
NEK3 |
0.743 | -0.248 | 1 | 0.715 |
LIMK2_TYR |
0.743 | -0.162 | -3 | 0.743 |
MOK |
0.742 | -0.107 | 1 | 0.644 |
HCK |
0.742 | 0.035 | -1 | 0.818 |
CSF1R |
0.742 | -0.013 | 3 | 0.795 |
MST1R |
0.742 | -0.125 | 3 | 0.816 |
ROS1 |
0.742 | -0.078 | 3 | 0.778 |
EPHB3 |
0.741 | 0.039 | -1 | 0.833 |
FYN |
0.741 | 0.147 | -1 | 0.797 |
JAK3 |
0.741 | -0.030 | 1 | 0.720 |
TAO1 |
0.740 | -0.123 | 1 | 0.681 |
JAK2 |
0.740 | -0.111 | 1 | 0.752 |
LIMK1_TYR |
0.739 | -0.239 | 2 | 0.811 |
FGFR2 |
0.738 | -0.026 | 3 | 0.808 |
ITK |
0.738 | 0.007 | -1 | 0.790 |
TEC |
0.738 | 0.044 | -1 | 0.736 |
ASK1 |
0.738 | -0.200 | 1 | 0.703 |
DDR1 |
0.738 | -0.167 | 4 | 0.726 |
ABL1 |
0.738 | -0.007 | -1 | 0.826 |
CK1A |
0.738 | -0.089 | -3 | 0.354 |
EPHA5 |
0.737 | 0.113 | 2 | 0.730 |
KIT |
0.737 | -0.027 | 3 | 0.798 |
EPHA7 |
0.736 | 0.038 | 2 | 0.749 |
FLT3 |
0.736 | -0.029 | 3 | 0.801 |
BMX |
0.736 | 0.019 | -1 | 0.716 |
FLT1 |
0.735 | 0.025 | -1 | 0.879 |
KDR |
0.735 | -0.043 | 3 | 0.764 |
PDGFRB |
0.735 | -0.088 | 3 | 0.806 |
EPHA8 |
0.732 | 0.075 | -1 | 0.826 |
LYN |
0.732 | 0.048 | 3 | 0.724 |
MERTK |
0.732 | -0.026 | 3 | 0.782 |
FRK |
0.732 | 0.051 | -1 | 0.840 |
EPHA3 |
0.732 | -0.030 | 2 | 0.729 |
STLK3 |
0.732 | -0.157 | 1 | 0.707 |
FGFR3 |
0.731 | -0.005 | 3 | 0.783 |
NTRK1 |
0.731 | -0.050 | -1 | 0.839 |
SYK |
0.731 | 0.127 | -1 | 0.810 |
TNK2 |
0.731 | -0.127 | 3 | 0.762 |
MET |
0.731 | -0.037 | 3 | 0.787 |
LTK |
0.730 | -0.052 | 3 | 0.743 |
EGFR |
0.730 | 0.047 | 1 | 0.610 |
PTK2 |
0.730 | 0.093 | -1 | 0.809 |
PTK6 |
0.730 | -0.053 | -1 | 0.732 |
FGFR1 |
0.730 | -0.099 | 3 | 0.778 |
TEK |
0.729 | -0.117 | 3 | 0.750 |
TNNI3K_TYR |
0.729 | -0.095 | 1 | 0.783 |
AXL |
0.729 | -0.111 | 3 | 0.786 |
MATK |
0.728 | -0.016 | -1 | 0.783 |
ERBB2 |
0.728 | -0.057 | 1 | 0.704 |
BTK |
0.728 | -0.093 | -1 | 0.747 |
ALK |
0.727 | -0.081 | 3 | 0.722 |
JAK1 |
0.726 | -0.103 | 1 | 0.698 |
FLT4 |
0.726 | -0.068 | 3 | 0.762 |
SRC |
0.726 | 0.039 | -1 | 0.805 |
NEK10_TYR |
0.725 | -0.146 | 1 | 0.628 |
PTK2B |
0.725 | -0.013 | -1 | 0.773 |
DDR2 |
0.724 | -0.052 | 3 | 0.749 |
AAK1 |
0.724 | 0.004 | 1 | 0.579 |
EPHA1 |
0.724 | -0.083 | 3 | 0.768 |
CK1G3 |
0.724 | -0.073 | -3 | 0.312 |
CSK |
0.724 | 0.006 | 2 | 0.759 |
FGFR4 |
0.724 | 0.033 | -1 | 0.813 |
INSR |
0.724 | -0.074 | 3 | 0.741 |
NTRK2 |
0.724 | -0.100 | 3 | 0.764 |
WEE1_TYR |
0.723 | -0.108 | -1 | 0.748 |
PDGFRA |
0.722 | -0.202 | 3 | 0.807 |
TNK1 |
0.722 | -0.188 | 3 | 0.784 |
NTRK3 |
0.722 | -0.059 | -1 | 0.791 |
EPHA2 |
0.721 | 0.049 | -1 | 0.802 |
IGF1R |
0.715 | -0.021 | 3 | 0.683 |
ERBB4 |
0.714 | 0.008 | 1 | 0.641 |
YANK2 |
0.712 | -0.084 | 2 | 0.443 |
CK1G2 |
0.709 | -0.059 | -3 | 0.416 |
MUSK |
0.704 | -0.134 | 1 | 0.587 |
FES |
0.696 | -0.093 | -1 | 0.704 |
ZAP70 |
0.694 | -0.029 | -1 | 0.723 |