Motif 614 (n=169)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S1066 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A1L390 | PLEKHG3 | S894 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A2A3K4 | PTPDC1 | S394 | ochoa | Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) | May play roles in cilia formation and/or maintenance. {ECO:0000250}. |
| A6H8Y1 | BDP1 | S774 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NC98 | CCDC88B | S429 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NHR9 | SMCHD1 | S1709 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| B4DGG1 | FAM234A | S21 | ochoa | Protein FAM234A (Protein ITFG3) | None |
| K7ELQ4 | ATF7-NPFF | S73 | ochoa | ATF7-NPFF readthrough | None |
| O00567 | NOP56 | S461 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14974 | PPP1R12A | S304 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15117 | FYB1 | S558 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O43379 | WDR62 | S1436 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43399 | TPD52L2 | S84 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43399 | TPD52L2 | S96 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43781 | DYRK3 | S350 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| O60763 | USO1 | S881 | ochoa | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O75348 | ATP6V1G1 | S70 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75420 | GIGYF1 | S442 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75821 | EIF3G | S189 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O94876 | TMCC1 | S479 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
| O95071 | UBR5 | S2434 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95239 | KIF4A | S941 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95613 | PCNT | S2479 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S2878 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95696 | BRD1 | S499 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95801 | TTC4 | S47 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| P02545 | LMNA | Y45 | psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S66 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05783 | KRT18 | Y94 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P05976 | MYL1 | S68 | ochoa | Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2) | Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}. |
| P06239 | LCK | S94 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08670 | VIM | Y117 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09467 | FBP1 | S88 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P11055 | MYH3 | T1696 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12814 | ACTN1 | S348 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | T1439 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1699 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1435 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1491 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1695 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1437 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1493 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1697 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P14672 | SLC2A4 | S274 | psp | Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. {ECO:0000250|UniProtKB:P19357}. |
| P15311 | EZR | Y354 | ochoa|psp | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P16157 | ANK1 | S1428 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P16885 | PLCG2 | Y1217 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P18206 | VCL | S726 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P22234 | PAICS | S274 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P23508 | MCC | S120 | ochoa|psp | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P30622 | CLIP1 | S1304 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P33981 | TTK | S582 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | T1151 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1243 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1292 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1713 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1720 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37023 | ACVRL1 | S160 | ochoa | Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I) | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:26176610}. |
| P42566 | EPS15 | S485 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42768 | WAS | S277 | ochoa | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P46013 | MKI67 | S1414 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48163 | ME1 | S336 | psp | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| P48681 | NES | S814 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49902 | NT5C2 | S409 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P53621 | COPA | S895 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P54252 | ATXN3 | S236 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P55010 | EIF5 | S229 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| P55160 | NCKAP1L | S1084 | ochoa | Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) | Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000269|PubMed:32647003, ECO:0000303|PubMed:20969869}. |
| Q01082 | SPTBN1 | S2041 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02241 | KIF23 | Y582 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02410 | APBA1 | S78 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q03014 | HHEX | S177 | psp | Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein) | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}. |
| Q05397 | PTK2 | S840 | ochoa|psp | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q13200 | PSMD2 | S147 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13263 | TRIM28 | S689 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13439 | GOLGA4 | S181 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q14254 | FLOT2 | S405 | ochoa | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Q14694 | USP10 | S549 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14789 | GOLGB1 | S1936 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S3037 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | T3072 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14980 | NUMA1 | S820 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14BN4 | SLMAP | S402 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q15003 | NCAPH | S233 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15075 | EEA1 | S356 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15149 | PLEC | S2749 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15643 | TRIP11 | S486 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15643 | TRIP11 | S595 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15772 | SPEG | S476 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q2KHM9 | KIAA0753 | S672 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q5JSZ5 | PRRC2B | S980 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5THK1 | PRR14L | S1971 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q6EKJ0 | GTF2IRD2B | S500 | ochoa | General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) | None |
| Q6P9H4 | CNKSR3 | S44 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6PII3 | CCDC174 | S197 | ochoa | Coiled-coil domain-containing protein 174 | Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}. |
| Q6WKZ4 | RAB11FIP1 | S234 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZT07 | TBC1D9 | S1192 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZU80 | CEP128 | S86 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q6ZU80 | CEP128 | S298 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7L591 | DOK3 | S383 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q86SQ0 | PHLDB2 | Y686 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UP2 | KTN1 | S1244 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86VS8 | HOOK3 | S230 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86XA9 | HEATR5A | S1704 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86XJ1 | GAS2L3 | S195 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86Y82 | STX12 | S94 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q86YS7 | C2CD5 | S671 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IUD2 | ERC1 | S415 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IWJ2 | GCC2 | S935 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IY81 | FTSJ3 | S677 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8IY92 | SLX4 | S57 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N4C6 | NIN | S1540 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8WTT2 | NOC3L | S117 | ochoa | Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) | May be required for adipogenesis. {ECO:0000250}. |
| Q8WVV4 | POF1B | S156 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q92585 | MAML1 | S261 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92681 | RSC1A1 | S366 | psp | Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1) | Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}. |
| Q96C24 | SYTL4 | S209 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96CV9 | OPTN | S171 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96MT8 | CEP63 | S530 | ochoa | Centrosomal protein of 63 kDa (Cep63) | Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368). {ECO:0000269|PubMed:21406398, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:35793002, ECO:0000269|PubMed:35989368}. |
| Q96S82 | UBL7 | S123 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q96T23 | RSF1 | S516 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99590 | SCAF11 | S614 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BRV8 | SIKE1 | S187 | ochoa|psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
| Q9BSJ2 | TUBGCP2 | S320 | ochoa | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809, PubMed:9566967). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). Plays a role in neuronal migration (PubMed:31630790). {ECO:0000269|PubMed:31630790, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809, ECO:0000269|PubMed:9566967}. |
| Q9BV73 | CEP250 | S2179 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BV73 | CEP250 | S2234 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BV73 | CEP250 | S2421 | ochoa|psp | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BVJ6 | UTP14A | S437 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BYM8 | RBCK1 | S359 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BYX2 | TBC1D2 | Y903 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9H0X4 | FAM234A | S21 | ochoa | Protein FAM234A (Protein ITFG3) | None |
| Q9H2U1 | DHX36 | S963 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H6L5 | RETREG1 | S153 | ochoa | Reticulophagy regulator 1 (Reticulophagy receptor 1) | Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q8VE91, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:34338405}.; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:35239449}. |
| Q9H9S0 | NANOG | S135 | psp | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9HAW4 | CLSPN | S950 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9NRR4 | DROSHA | S807 | ochoa | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NSI2 | SLX9 | S203 | ochoa | Ribosome biogenesis protein SLX9 homolog | May be involved in ribosome biogenesis. {ECO:0000250|UniProtKB:P53251}. |
| Q9P0V9 | SEPTIN10 | S427 | ochoa | Septin-10 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}. |
| Q9P219 | CCDC88C | S446 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P275 | USP36 | S937 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UEY8 | ADD3 | S590 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | S708 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHY8 | FEZ2 | S208 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UID6 | ZNF639 | S182 | ochoa | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}. |
| Q9UKA4 | AKAP11 | S1171 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKX2 | MYH2 | T1441 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1701 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD9 | ZNF608 | S871 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9UPN4 | CEP131 | S745 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y4F1 | FARP1 | S613 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y616 | IRAK3 | S152 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| Q9Y6D9 | MAD1L1 | S214 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6K9 | IKBKG | S68 | psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9NYB9 | ABI2 | S22 | Sugiyama | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| O60763 | USO1 | S751 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| Q12931 | TRAP1 | S482 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q9Y2W2 | WBP11 | Y124 | Sugiyama | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q8IZP0 | ABI1 | S22 | Sugiyama | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| O15085 | ARHGEF11 | Y200 | Sugiyama | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| P20700 | LMNB1 | Y46 | Sugiyama | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| Q14980 | NUMA1 | S1181 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| P35580 | MYH10 | S1699 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| O00401 | WASL | S242 | EPSD | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| Q13470 | TNK1 | S124 | Sugiyama | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q08378 | GOLGA3 | S501 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08378 | GOLGA3 | S1093 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q14980 | NUMA1 | S863 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q9P2E9 | RRBP1 | S1233 | Sugiyama | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| P35580 | MYH10 | T1158 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000003 | 5.540 |
| R-HSA-68886 | M Phase | 0.000016 | 4.792 |
| R-HSA-75153 | Apoptotic execution phase | 0.000021 | 4.682 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000099 | 4.003 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000132 | 3.879 |
| R-HSA-1640170 | Cell Cycle | 0.000150 | 3.823 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.000167 | 3.779 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.000213 | 3.671 |
| R-HSA-9664407 | Parasite infection | 0.000213 | 3.671 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.000213 | 3.671 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.000223 | 3.652 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000298 | 3.526 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000330 | 3.481 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.000372 | 3.429 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.000444 | 3.353 |
| R-HSA-199991 | Membrane Trafficking | 0.000453 | 3.344 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.000491 | 3.309 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000770 | 3.113 |
| R-HSA-69275 | G2/M Transition | 0.001206 | 2.919 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.001387 | 2.858 |
| R-HSA-202433 | Generation of second messenger molecules | 0.001391 | 2.857 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.001281 | 2.892 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.001464 | 2.834 |
| R-HSA-380287 | Centrosome maturation | 0.001628 | 2.788 |
| R-HSA-202403 | TCR signaling | 0.001583 | 2.801 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.001711 | 2.767 |
| R-HSA-5357801 | Programmed Cell Death | 0.002147 | 2.668 |
| R-HSA-373753 | Nephrin family interactions | 0.002165 | 2.665 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.002353 | 2.628 |
| R-HSA-109581 | Apoptosis | 0.002471 | 2.607 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.002688 | 2.571 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.003183 | 2.497 |
| R-HSA-9658195 | Leishmania infection | 0.003650 | 2.438 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.003650 | 2.438 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.004708 | 2.327 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.004787 | 2.320 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.004314 | 2.365 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.004697 | 2.328 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.004697 | 2.328 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.004362 | 2.360 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.003922 | 2.407 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.005522 | 2.258 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.006019 | 2.220 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.006019 | 2.220 |
| R-HSA-373755 | Semaphorin interactions | 0.006019 | 2.220 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.006691 | 2.174 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.006941 | 2.159 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.007661 | 2.116 |
| R-HSA-1500931 | Cell-Cell communication | 0.007320 | 2.135 |
| R-HSA-5689877 | Josephin domain DUBs | 0.007801 | 2.108 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.009069 | 2.042 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.009662 | 2.015 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.010914 | 1.962 |
| R-HSA-68875 | Mitotic Prophase | 0.011907 | 1.924 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.014475 | 1.839 |
| R-HSA-373752 | Netrin-1 signaling | 0.016009 | 1.796 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.016023 | 1.795 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.018367 | 1.736 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.017671 | 1.753 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.021067 | 1.676 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.022876 | 1.641 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.029733 | 1.527 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.029733 | 1.527 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.028669 | 1.543 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.024748 | 1.606 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.025187 | 1.599 |
| R-HSA-75893 | TNF signaling | 0.027375 | 1.563 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.026414 | 1.578 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.028473 | 1.546 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.024152 | 1.617 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.028473 | 1.546 |
| R-HSA-422475 | Axon guidance | 0.028720 | 1.542 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.029489 | 1.530 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.027375 | 1.563 |
| R-HSA-168249 | Innate Immune System | 0.030586 | 1.514 |
| R-HSA-397014 | Muscle contraction | 0.030762 | 1.512 |
| R-HSA-449147 | Signaling by Interleukins | 0.030861 | 1.511 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.032821 | 1.484 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.032947 | 1.482 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.032947 | 1.482 |
| R-HSA-68882 | Mitotic Anaphase | 0.033012 | 1.481 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.033591 | 1.474 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.042192 | 1.375 |
| R-HSA-9675108 | Nervous system development | 0.042216 | 1.375 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.042068 | 1.376 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.037193 | 1.430 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.037193 | 1.430 |
| R-HSA-373760 | L1CAM interactions | 0.043189 | 1.365 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.044140 | 1.355 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.044140 | 1.355 |
| R-HSA-77387 | Insulin receptor recycling | 0.046555 | 1.332 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.049017 | 1.310 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.049064 | 1.309 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.049146 | 1.309 |
| R-HSA-2424491 | DAP12 signaling | 0.051526 | 1.288 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.056676 | 1.247 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.058586 | 1.232 |
| R-HSA-194138 | Signaling by VEGF | 0.053889 | 1.269 |
| R-HSA-5688426 | Deubiquitination | 0.060599 | 1.218 |
| R-HSA-9659379 | Sensory processing of sound | 0.058355 | 1.234 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.051526 | 1.288 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.059964 | 1.222 |
| R-HSA-1474165 | Reproduction | 0.060938 | 1.215 |
| R-HSA-5617833 | Cilium Assembly | 0.061150 | 1.214 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.062144 | 1.207 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.064721 | 1.189 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.068014 | 1.167 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.086587 | 1.063 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.104793 | 0.980 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.122638 | 0.911 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.140130 | 0.853 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.148745 | 0.828 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.182357 | 0.739 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.190552 | 0.720 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.198665 | 0.702 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.090883 | 1.042 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.260727 | 0.584 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.136302 | 0.865 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.275481 | 0.560 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.167632 | 0.776 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.244202 | 0.612 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.244202 | 0.612 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.304117 | 0.517 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.230318 | 0.638 |
| R-HSA-9646399 | Aggrephagy | 0.081852 | 1.087 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.157275 | 0.803 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.238035 | 0.623 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.245675 | 0.610 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.148745 | 0.828 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.282748 | 0.549 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.304117 | 0.517 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.126180 | 0.899 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.245675 | 0.610 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.068014 | 1.167 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.245675 | 0.610 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.307222 | 0.513 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.296493 | 0.528 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.094277 | 1.026 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.240498 | 0.619 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.077347 | 1.112 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.095736 | 1.019 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.157275 | 0.803 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.174080 | 0.759 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.245675 | 0.610 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.260727 | 0.584 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.311099 | 0.507 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.200037 | 0.699 |
| R-HSA-447043 | Neurofascin interactions | 0.086587 | 1.063 |
| R-HSA-437239 | Recycling pathway of L1 | 0.106537 | 0.973 |
| R-HSA-2172127 | DAP12 interactions | 0.097059 | 1.013 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.222523 | 0.653 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.245675 | 0.610 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.119538 | 0.922 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.165719 | 0.781 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.277422 | 0.557 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.077347 | 1.112 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.104793 | 0.980 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.140130 | 0.853 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.174080 | 0.759 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.214650 | 0.668 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.230318 | 0.638 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.318010 | 0.498 |
| R-HSA-354192 | Integrin signaling | 0.324853 | 0.488 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.187782 | 0.726 |
| R-HSA-9663891 | Selective autophagy | 0.075356 | 1.123 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.289943 | 0.538 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.097059 | 1.013 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.157047 | 0.804 |
| R-HSA-983189 | Kinesins | 0.150064 | 0.824 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.324853 | 0.488 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.182357 | 0.739 |
| R-HSA-182971 | EGFR downregulation | 0.311099 | 0.507 |
| R-HSA-114608 | Platelet degranulation | 0.172822 | 0.762 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.245675 | 0.610 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.185530 | 0.732 |
| R-HSA-447038 | NrCAM interactions | 0.068014 | 1.167 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.140130 | 0.853 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.148745 | 0.828 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.148745 | 0.828 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.165719 | 0.781 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.182357 | 0.739 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.073123 | 1.136 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.106537 | 0.973 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.126180 | 0.899 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.268141 | 0.572 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.160561 | 0.794 |
| R-HSA-9612973 | Autophagy | 0.255794 | 0.592 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.261180 | 0.583 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.282748 | 0.549 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.297065 | 0.527 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.324853 | 0.488 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.073686 | 1.133 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.190308 | 0.721 |
| R-HSA-202424 | Downstream TCR signaling | 0.078992 | 1.102 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.104399 | 0.981 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.077347 | 1.112 |
| R-HSA-164944 | Nef and signal transduction | 0.086587 | 1.063 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.095736 | 1.019 |
| R-HSA-447041 | CHL1 interactions | 0.095736 | 1.019 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.131428 | 0.881 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.238035 | 0.623 |
| R-HSA-9766229 | Degradation of CDH1 | 0.112988 | 0.947 |
| R-HSA-73887 | Death Receptor Signaling | 0.096737 | 1.014 |
| R-HSA-1632852 | Macroautophagy | 0.213411 | 0.671 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.067484 | 1.171 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.206698 | 0.685 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.259038 | 0.587 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.094277 | 1.026 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.329295 | 0.482 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.077347 | 1.112 |
| R-HSA-8963676 | Intestinal absorption | 0.104793 | 0.980 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.157275 | 0.803 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.198665 | 0.702 |
| R-HSA-9755088 | Ribavirin ADME | 0.238035 | 0.623 |
| R-HSA-1221632 | Meiotic synapsis | 0.126180 | 0.899 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.324853 | 0.488 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.299225 | 0.524 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.087744 | 1.057 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.129623 | 0.887 |
| R-HSA-210990 | PECAM1 interactions | 0.131428 | 0.881 |
| R-HSA-8854214 | TBC/RABGAPs | 0.093956 | 1.027 |
| R-HSA-2161541 | Abacavir metabolism | 0.230318 | 0.638 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.304117 | 0.517 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.306937 | 0.513 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.140130 | 0.853 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.190552 | 0.720 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.296132 | 0.529 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.174080 | 0.759 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.206698 | 0.685 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.268141 | 0.572 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.070284 | 1.153 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.297065 | 0.527 |
| R-HSA-1266738 | Developmental Biology | 0.130976 | 0.883 |
| R-HSA-6806834 | Signaling by MET | 0.222028 | 0.654 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.077868 | 1.109 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.310166 | 0.508 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.131428 | 0.881 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.258464 | 0.588 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.153548 | 0.814 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.174080 | 0.759 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.253239 | 0.596 |
| R-HSA-2161522 | Abacavir ADME | 0.275481 | 0.560 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.185530 | 0.732 |
| R-HSA-9758941 | Gastrulation | 0.089213 | 1.050 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.285018 | 0.545 |
| R-HSA-168256 | Immune System | 0.179418 | 0.746 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.190552 | 0.720 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.240498 | 0.619 |
| R-HSA-162582 | Signal Transduction | 0.087977 | 1.056 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.222523 | 0.653 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.238035 | 0.623 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.253239 | 0.596 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.324853 | 0.488 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.110671 | 0.956 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.238035 | 0.623 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.190360 | 0.720 |
| R-HSA-446728 | Cell junction organization | 0.182809 | 0.738 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.174080 | 0.759 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.198665 | 0.702 |
| R-HSA-3000170 | Syndecan interactions | 0.253239 | 0.596 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.134837 | 0.870 |
| R-HSA-1500620 | Meiosis | 0.240498 | 0.619 |
| R-HSA-917937 | Iron uptake and transport | 0.203685 | 0.691 |
| R-HSA-201451 | Signaling by BMP | 0.282748 | 0.549 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.273887 | 0.562 |
| R-HSA-189200 | Cellular hexose transport | 0.245675 | 0.610 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.255327 | 0.593 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.131428 | 0.881 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.292430 | 0.534 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.324853 | 0.488 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.304693 | 0.516 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.304693 | 0.516 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.242403 | 0.615 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.164560 | 0.784 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.309141 | 0.510 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.155834 | 0.807 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.167632 | 0.776 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.200037 | 0.699 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.247908 | 0.606 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.270175 | 0.568 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.207340 | 0.683 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.251617 | 0.599 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.331628 | 0.479 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.331628 | 0.479 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.331628 | 0.479 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.331628 | 0.479 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.331628 | 0.479 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.338335 | 0.471 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.338335 | 0.471 |
| R-HSA-5205647 | Mitophagy | 0.338335 | 0.471 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.338335 | 0.471 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.338335 | 0.471 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.338335 | 0.471 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.340263 | 0.468 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.340263 | 0.468 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.343907 | 0.464 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.344975 | 0.462 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.344975 | 0.462 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.344975 | 0.462 |
| R-HSA-169911 | Regulation of Apoptosis | 0.344975 | 0.462 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.345774 | 0.461 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.347544 | 0.459 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.347544 | 0.459 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.351549 | 0.454 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.351549 | 0.454 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.351549 | 0.454 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.351549 | 0.454 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.358057 | 0.446 |
| R-HSA-4641258 | Degradation of DVL | 0.358057 | 0.446 |
| R-HSA-4641257 | Degradation of AXIN | 0.358057 | 0.446 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.358057 | 0.446 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.358057 | 0.446 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.358057 | 0.446 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.362027 | 0.441 |
| R-HSA-8875878 | MET promotes cell motility | 0.364501 | 0.438 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.364501 | 0.438 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.364501 | 0.438 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.367628 | 0.435 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.369224 | 0.433 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.370880 | 0.431 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.370880 | 0.431 |
| R-HSA-69541 | Stabilization of p53 | 0.370880 | 0.431 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.376389 | 0.424 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.376389 | 0.424 |
| R-HSA-5260271 | Diseases of Immune System | 0.377195 | 0.423 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.377195 | 0.423 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.377195 | 0.423 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.377195 | 0.423 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.377195 | 0.423 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.377316 | 0.423 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.379960 | 0.420 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.383448 | 0.416 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.383448 | 0.416 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.383448 | 0.416 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.383448 | 0.416 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.383448 | 0.416 |
| R-HSA-9607240 | FLT3 Signaling | 0.383448 | 0.416 |
| R-HSA-5693538 | Homology Directed Repair | 0.383521 | 0.416 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.386651 | 0.413 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.387075 | 0.412 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.387075 | 0.412 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.389638 | 0.409 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.389638 | 0.409 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.389638 | 0.409 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.389638 | 0.409 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.389638 | 0.409 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.389638 | 0.409 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.389638 | 0.409 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.389638 | 0.409 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.389638 | 0.409 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.393201 | 0.405 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.394154 | 0.404 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.397680 | 0.400 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.397680 | 0.400 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.401197 | 0.397 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.401834 | 0.396 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.401834 | 0.396 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.404704 | 0.393 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.407840 | 0.390 |
| R-HSA-9907900 | Proteasome assembly | 0.407840 | 0.390 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.413787 | 0.383 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.413787 | 0.383 |
| R-HSA-774815 | Nucleosome assembly | 0.413787 | 0.383 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.413787 | 0.383 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.413787 | 0.383 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.413787 | 0.383 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.413787 | 0.383 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.413787 | 0.383 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.413787 | 0.383 |
| R-HSA-9824272 | Somitogenesis | 0.413787 | 0.383 |
| R-HSA-69481 | G2/M Checkpoints | 0.418634 | 0.378 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.419674 | 0.377 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.419674 | 0.377 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.419674 | 0.377 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.419674 | 0.377 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.419674 | 0.377 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.419674 | 0.377 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.419674 | 0.377 |
| R-HSA-109582 | Hemostasis | 0.421525 | 0.375 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.425503 | 0.371 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.425503 | 0.371 |
| R-HSA-418990 | Adherens junctions interactions | 0.429577 | 0.367 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.431273 | 0.365 |
| R-HSA-5620924 | Intraflagellar transport | 0.431273 | 0.365 |
| R-HSA-70263 | Gluconeogenesis | 0.431273 | 0.365 |
| R-HSA-9843745 | Adipogenesis | 0.435812 | 0.361 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.436986 | 0.360 |
| R-HSA-73893 | DNA Damage Bypass | 0.436986 | 0.360 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.436986 | 0.360 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.436986 | 0.360 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.442642 | 0.354 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.448241 | 0.348 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.448241 | 0.348 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.453784 | 0.343 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.453784 | 0.343 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.453784 | 0.343 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.453784 | 0.343 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.453784 | 0.343 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.459272 | 0.338 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.459272 | 0.338 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.459272 | 0.338 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.459272 | 0.338 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.459272 | 0.338 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.460867 | 0.336 |
| R-HSA-72649 | Translation initiation complex formation | 0.464706 | 0.333 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.464706 | 0.333 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.466032 | 0.332 |
| R-HSA-72312 | rRNA processing | 0.466253 | 0.331 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.470085 | 0.328 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.470085 | 0.328 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.475410 | 0.323 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.475410 | 0.323 |
| R-HSA-177929 | Signaling by EGFR | 0.475410 | 0.323 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.479156 | 0.320 |
| R-HSA-5621480 | Dectin-2 family | 0.480682 | 0.318 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.482407 | 0.317 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.485645 | 0.314 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.485901 | 0.313 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.491069 | 0.309 |
| R-HSA-186712 | Regulation of beta-cell development | 0.491069 | 0.309 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.496184 | 0.304 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.496184 | 0.304 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.496184 | 0.304 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.496184 | 0.304 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.496184 | 0.304 |
| R-HSA-351202 | Metabolism of polyamines | 0.496184 | 0.304 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.496184 | 0.304 |
| R-HSA-450294 | MAP kinase activation | 0.501249 | 0.300 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.501249 | 0.300 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.504808 | 0.297 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.505866 | 0.296 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.506263 | 0.296 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.506263 | 0.296 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.506263 | 0.296 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.511094 | 0.291 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.511227 | 0.291 |
| R-HSA-8963743 | Digestion and absorption | 0.511227 | 0.291 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.514217 | 0.289 |
| R-HSA-421270 | Cell-cell junction organization | 0.514302 | 0.289 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.516141 | 0.287 |
| R-HSA-1989781 | PPARA activates gene expression | 0.520424 | 0.284 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.521006 | 0.283 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.526578 | 0.279 |
| R-HSA-9711097 | Cellular response to starvation | 0.529635 | 0.276 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.530591 | 0.275 |
| R-HSA-5218859 | Regulated Necrosis | 0.535311 | 0.271 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.544612 | 0.264 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.544612 | 0.264 |
| R-HSA-448424 | Interleukin-17 signaling | 0.544612 | 0.264 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.544612 | 0.264 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.544612 | 0.264 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.549192 | 0.260 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.549192 | 0.260 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.549192 | 0.260 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.553727 | 0.257 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.553727 | 0.257 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.553727 | 0.257 |
| R-HSA-74259 | Purine catabolism | 0.553727 | 0.257 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.555299 | 0.255 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.558217 | 0.253 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.558217 | 0.253 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.567061 | 0.246 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.567061 | 0.246 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.571417 | 0.243 |
| R-HSA-5689603 | UCH proteinases | 0.571417 | 0.243 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.576718 | 0.239 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.576718 | 0.239 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.579999 | 0.237 |
| R-HSA-5619084 | ABC transporter disorders | 0.579999 | 0.237 |
| R-HSA-4086400 | PCP/CE pathway | 0.579999 | 0.237 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.588410 | 0.230 |
| R-HSA-9833482 | PKR-mediated signaling | 0.588410 | 0.230 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.592553 | 0.227 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.600714 | 0.221 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.604366 | 0.219 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.604734 | 0.218 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.608713 | 0.216 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.612653 | 0.213 |
| R-HSA-983712 | Ion channel transport | 0.620293 | 0.207 |
| R-HSA-70268 | Pyruvate metabolism | 0.620414 | 0.207 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.620414 | 0.207 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.631031 | 0.200 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.631766 | 0.199 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.635475 | 0.197 |
| R-HSA-391251 | Protein folding | 0.642782 | 0.192 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.646380 | 0.190 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.646380 | 0.190 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.648211 | 0.188 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.649943 | 0.187 |
| R-HSA-1474290 | Collagen formation | 0.649943 | 0.187 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.656961 | 0.182 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.656961 | 0.182 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.667227 | 0.176 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.667227 | 0.176 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.667227 | 0.176 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.667227 | 0.176 |
| R-HSA-1643685 | Disease | 0.668988 | 0.175 |
| R-HSA-3214847 | HATs acetylate histones | 0.670580 | 0.174 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.670580 | 0.174 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.670580 | 0.174 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.673901 | 0.171 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.673901 | 0.171 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.677187 | 0.169 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.680441 | 0.167 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.680441 | 0.167 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.681376 | 0.167 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.686852 | 0.163 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.696228 | 0.157 |
| R-HSA-69239 | Synthesis of DNA | 0.699291 | 0.155 |
| R-HSA-211000 | Gene Silencing by RNA | 0.699291 | 0.155 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.702324 | 0.153 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.702324 | 0.153 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.705326 | 0.152 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.705326 | 0.152 |
| R-HSA-6798695 | Neutrophil degranulation | 0.711221 | 0.148 |
| R-HSA-162906 | HIV Infection | 0.711959 | 0.148 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.714048 | 0.146 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.714153 | 0.146 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.714153 | 0.146 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.717036 | 0.144 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.717036 | 0.144 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.722717 | 0.141 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.728284 | 0.138 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.728284 | 0.138 |
| R-HSA-15869 | Metabolism of nucleotides | 0.730304 | 0.136 |
| R-HSA-70326 | Glucose metabolism | 0.733740 | 0.134 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.736427 | 0.133 |
| R-HSA-157118 | Signaling by NOTCH | 0.738136 | 0.132 |
| R-HSA-73894 | DNA Repair | 0.738253 | 0.132 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.739087 | 0.131 |
| R-HSA-73886 | Chromosome Maintenance | 0.744327 | 0.128 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.749463 | 0.125 |
| R-HSA-5663205 | Infectious disease | 0.750622 | 0.125 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.751992 | 0.124 |
| R-HSA-1280218 | Adaptive Immune System | 0.752495 | 0.123 |
| R-HSA-69206 | G1/S Transition | 0.756975 | 0.121 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.759429 | 0.120 |
| R-HSA-8956319 | Nucleotide catabolism | 0.766644 | 0.115 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.767561 | 0.115 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.769001 | 0.114 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.774884 | 0.111 |
| R-HSA-9909396 | Circadian clock | 0.775931 | 0.110 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.787024 | 0.104 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.791307 | 0.102 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.791307 | 0.102 |
| R-HSA-6807070 | PTEN Regulation | 0.793416 | 0.100 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.794259 | 0.100 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.809284 | 0.092 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.809545 | 0.092 |
| R-HSA-69242 | S Phase | 0.813377 | 0.090 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.817133 | 0.088 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.820814 | 0.086 |
| R-HSA-69306 | DNA Replication | 0.822627 | 0.085 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.824421 | 0.084 |
| R-HSA-2262752 | Cellular responses to stress | 0.826748 | 0.083 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.827552 | 0.082 |
| R-HSA-195721 | Signaling by WNT | 0.831539 | 0.080 |
| R-HSA-72766 | Translation | 0.833396 | 0.079 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.834816 | 0.078 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.834816 | 0.078 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.855285 | 0.068 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.859639 | 0.066 |
| R-HSA-611105 | Respiratory electron transport | 0.863862 | 0.064 |
| R-HSA-2559583 | Cellular Senescence | 0.866608 | 0.062 |
| R-HSA-1474244 | Extracellular matrix organization | 0.870232 | 0.060 |
| R-HSA-597592 | Post-translational protein modification | 0.873673 | 0.059 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.880246 | 0.055 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.881208 | 0.055 |
| R-HSA-382551 | Transport of small molecules | 0.882731 | 0.054 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.884343 | 0.053 |
| R-HSA-9609690 | HCMV Early Events | 0.886678 | 0.052 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.887742 | 0.052 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.894486 | 0.048 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.894486 | 0.048 |
| R-HSA-72172 | mRNA Splicing | 0.896617 | 0.047 |
| R-HSA-6805567 | Keratinization | 0.898705 | 0.046 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.904722 | 0.043 |
| R-HSA-9748784 | Drug ADME | 0.910383 | 0.041 |
| R-HSA-8951664 | Neddylation | 0.913087 | 0.039 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.917414 | 0.037 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.923897 | 0.034 |
| R-HSA-8939211 | ESR-mediated signaling | 0.926195 | 0.033 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.926195 | 0.033 |
| R-HSA-9679506 | SARS-CoV Infections | 0.931694 | 0.031 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.933370 | 0.030 |
| R-HSA-4839726 | Chromatin organization | 0.934720 | 0.029 |
| R-HSA-9609646 | HCMV Infection | 0.935384 | 0.029 |
| R-HSA-8953854 | Metabolism of RNA | 0.935559 | 0.029 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.951987 | 0.021 |
| R-HSA-112316 | Neuronal System | 0.958900 | 0.018 |
| R-HSA-1483257 | Phospholipid metabolism | 0.959253 | 0.018 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.969436 | 0.013 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.969436 | 0.013 |
| R-HSA-9824446 | Viral Infection Pathways | 0.976882 | 0.010 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.979751 | 0.009 |
| R-HSA-392499 | Metabolism of proteins | 0.980019 | 0.009 |
| R-HSA-913531 | Interferon Signaling | 0.983693 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.984830 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.992256 | 0.003 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.993019 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998583 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999716 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999726 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999795 | 0.000 |
| R-HSA-74160 | Gene expression (Transcription) | 0.999873 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999886 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.999917 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999981 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
DSTYK |
0.826 | 0.207 | 2 | 0.842 |
COT |
0.820 | 0.016 | 2 | 0.798 |
NEK7 |
0.816 | 0.215 | -3 | 0.637 |
CLK3 |
0.815 | 0.075 | 1 | 0.851 |
NEK6 |
0.813 | 0.155 | -2 | 0.855 |
CDC7 |
0.811 | 0.045 | 1 | 0.915 |
FAM20C |
0.810 | 0.184 | 2 | 0.720 |
RAF1 |
0.809 | 0.024 | 1 | 0.882 |
BMPR1B |
0.809 | 0.151 | 1 | 0.841 |
PRPK |
0.808 | -0.107 | -1 | 0.793 |
MOS |
0.807 | -0.006 | 1 | 0.920 |
MARK4 |
0.807 | 0.099 | 4 | 0.876 |
ULK2 |
0.807 | 0.036 | 2 | 0.687 |
BMPR2 |
0.807 | -0.027 | -2 | 0.855 |
ATR |
0.807 | 0.065 | 1 | 0.890 |
CAMK1B |
0.806 | -0.024 | -3 | 0.552 |
CAMK2G |
0.806 | 0.001 | 2 | 0.771 |
GCN2 |
0.805 | -0.042 | 2 | 0.721 |
NLK |
0.805 | 0.023 | 1 | 0.834 |
NUAK2 |
0.805 | 0.017 | -3 | 0.527 |
PIM3 |
0.804 | -0.036 | -3 | 0.488 |
TGFBR2 |
0.803 | 0.028 | -2 | 0.838 |
CDKL1 |
0.802 | -0.037 | -3 | 0.502 |
WNK1 |
0.801 | 0.016 | -2 | 0.799 |
IKKB |
0.801 | -0.081 | -2 | 0.718 |
MTOR |
0.801 | -0.081 | 1 | 0.807 |
ALK2 |
0.801 | 0.156 | -2 | 0.848 |
TGFBR1 |
0.800 | 0.115 | -2 | 0.852 |
PDHK4 |
0.800 | -0.152 | 1 | 0.881 |
NIK |
0.800 | -0.054 | -3 | 0.561 |
MST4 |
0.799 | -0.006 | 2 | 0.783 |
PIM1 |
0.799 | -0.001 | -3 | 0.460 |
HUNK |
0.799 | 0.014 | 2 | 0.691 |
ULK1 |
0.799 | 0.003 | -3 | 0.586 |
RSK2 |
0.799 | -0.010 | -3 | 0.475 |
PKN3 |
0.799 | -0.051 | -3 | 0.504 |
TBK1 |
0.798 | -0.098 | 1 | 0.769 |
MLK1 |
0.798 | -0.062 | 2 | 0.751 |
ATM |
0.798 | 0.070 | 1 | 0.854 |
NEK9 |
0.797 | 0.052 | 2 | 0.749 |
PDHK1 |
0.797 | -0.103 | 1 | 0.871 |
ALK4 |
0.797 | 0.081 | -2 | 0.861 |
DAPK2 |
0.797 | -0.023 | -3 | 0.556 |
AMPKA1 |
0.797 | 0.004 | -3 | 0.522 |
BMPR1A |
0.797 | 0.148 | 1 | 0.841 |
CAMLCK |
0.796 | -0.031 | -2 | 0.792 |
TSSK2 |
0.796 | 0.025 | -5 | 0.749 |
NDR2 |
0.795 | -0.069 | -3 | 0.483 |
NDR1 |
0.795 | -0.051 | -3 | 0.498 |
GRK6 |
0.795 | -0.015 | 1 | 0.886 |
ACVR2A |
0.795 | 0.078 | -2 | 0.829 |
MARK2 |
0.795 | 0.111 | 4 | 0.851 |
P70S6KB |
0.795 | -0.018 | -3 | 0.497 |
IKKE |
0.794 | -0.089 | 1 | 0.763 |
ACVR2B |
0.794 | 0.078 | -2 | 0.837 |
CAMK2B |
0.794 | 0.027 | 2 | 0.784 |
QSK |
0.793 | 0.061 | 4 | 0.876 |
SRPK1 |
0.793 | -0.016 | -3 | 0.457 |
SRPK2 |
0.793 | -0.002 | -3 | 0.404 |
WNK3 |
0.793 | -0.088 | 1 | 0.845 |
PLK1 |
0.793 | 0.044 | -2 | 0.826 |
SKMLCK |
0.793 | -0.047 | -2 | 0.806 |
GRK1 |
0.793 | -0.001 | -2 | 0.746 |
TSSK1 |
0.792 | 0.009 | -3 | 0.530 |
PKN2 |
0.792 | -0.049 | -3 | 0.532 |
ANKRD3 |
0.792 | -0.056 | 1 | 0.866 |
MARK3 |
0.792 | 0.101 | 4 | 0.873 |
SIK |
0.792 | 0.032 | -3 | 0.466 |
PRKD2 |
0.791 | -0.033 | -3 | 0.465 |
CHAK2 |
0.791 | -0.051 | -1 | 0.794 |
CAMK2D |
0.791 | -0.042 | -3 | 0.528 |
NUAK1 |
0.791 | -0.007 | -3 | 0.485 |
AMPKA2 |
0.791 | -0.005 | -3 | 0.500 |
QIK |
0.790 | 0.011 | -3 | 0.542 |
GRK5 |
0.790 | -0.146 | -3 | 0.535 |
LATS2 |
0.790 | -0.046 | -5 | 0.708 |
NEK2 |
0.790 | 0.081 | 2 | 0.729 |
PRKD1 |
0.790 | -0.056 | -3 | 0.487 |
PKCD |
0.790 | -0.036 | 2 | 0.710 |
P90RSK |
0.790 | -0.052 | -3 | 0.472 |
PKR |
0.790 | -0.018 | 1 | 0.849 |
RSK3 |
0.789 | -0.044 | -3 | 0.467 |
NIM1 |
0.789 | -0.024 | 3 | 0.775 |
CLK4 |
0.789 | 0.013 | -3 | 0.475 |
CDKL5 |
0.789 | -0.056 | -3 | 0.493 |
HIPK4 |
0.789 | -0.021 | 1 | 0.787 |
IKKA |
0.789 | -0.067 | -2 | 0.720 |
MAPKAPK2 |
0.789 | -0.024 | -3 | 0.416 |
CLK1 |
0.789 | 0.026 | -3 | 0.472 |
DNAPK |
0.788 | 0.086 | 1 | 0.783 |
SRPK3 |
0.788 | -0.017 | -3 | 0.442 |
MAPKAPK3 |
0.788 | -0.068 | -3 | 0.458 |
DLK |
0.787 | -0.165 | 1 | 0.862 |
PLK3 |
0.787 | 0.017 | 2 | 0.705 |
RIPK3 |
0.787 | -0.110 | 3 | 0.708 |
MARK1 |
0.787 | 0.070 | 4 | 0.870 |
BRAF |
0.786 | 0.080 | -4 | 0.800 |
CLK2 |
0.786 | 0.045 | -3 | 0.444 |
ERK5 |
0.786 | -0.070 | 1 | 0.742 |
LATS1 |
0.786 | -0.037 | -3 | 0.491 |
GRK7 |
0.786 | 0.011 | 1 | 0.817 |
ICK |
0.785 | -0.071 | -3 | 0.517 |
GRK4 |
0.785 | -0.095 | -2 | 0.809 |
CAMK2A |
0.785 | -0.015 | 2 | 0.782 |
KIS |
0.785 | -0.008 | 1 | 0.682 |
PINK1 |
0.784 | 0.078 | 1 | 0.835 |
BCKDK |
0.784 | -0.128 | -1 | 0.737 |
RSK4 |
0.784 | -0.012 | -3 | 0.438 |
MEK1 |
0.784 | -0.091 | 2 | 0.757 |
PKACG |
0.784 | -0.055 | -2 | 0.663 |
BRSK1 |
0.784 | -0.010 | -3 | 0.477 |
AURC |
0.783 | 0.003 | -2 | 0.598 |
MLK3 |
0.783 | -0.060 | 2 | 0.687 |
PRKD3 |
0.783 | -0.050 | -3 | 0.466 |
MLK2 |
0.782 | -0.142 | 2 | 0.751 |
TTBK2 |
0.782 | -0.123 | 2 | 0.613 |
PIM2 |
0.782 | -0.003 | -3 | 0.464 |
MSK2 |
0.782 | -0.061 | -3 | 0.435 |
SSTK |
0.782 | 0.052 | 4 | 0.845 |
AURB |
0.781 | 0.008 | -2 | 0.600 |
TLK2 |
0.781 | -0.034 | 1 | 0.850 |
PKACB |
0.781 | -0.008 | -2 | 0.614 |
SMG1 |
0.780 | 0.015 | 1 | 0.845 |
MYLK4 |
0.780 | -0.030 | -2 | 0.718 |
MELK |
0.780 | -0.063 | -3 | 0.498 |
AKT2 |
0.780 | -0.024 | -3 | 0.428 |
IRE1 |
0.780 | -0.088 | 1 | 0.789 |
YSK4 |
0.780 | -0.107 | 1 | 0.806 |
RIPK1 |
0.780 | -0.156 | 1 | 0.818 |
MLK4 |
0.780 | -0.076 | 2 | 0.668 |
MSK1 |
0.779 | -0.028 | -3 | 0.443 |
PAK6 |
0.779 | 0.022 | -2 | 0.640 |
CHAK1 |
0.779 | -0.064 | 2 | 0.686 |
CAMK4 |
0.778 | -0.115 | -3 | 0.504 |
IRE2 |
0.778 | -0.066 | 2 | 0.643 |
BRSK2 |
0.778 | -0.030 | -3 | 0.501 |
PAK1 |
0.778 | -0.058 | -2 | 0.709 |
PERK |
0.778 | -0.038 | -2 | 0.833 |
CDK8 |
0.778 | -0.033 | 1 | 0.664 |
TLK1 |
0.778 | -0.032 | -2 | 0.857 |
HRI |
0.778 | -0.047 | -2 | 0.837 |
MASTL |
0.778 | -0.274 | -2 | 0.765 |
NEK5 |
0.778 | 0.041 | 1 | 0.840 |
MNK2 |
0.777 | -0.052 | -2 | 0.734 |
VRK2 |
0.777 | -0.211 | 1 | 0.882 |
PKCB |
0.777 | -0.060 | 2 | 0.676 |
AURA |
0.776 | -0.007 | -2 | 0.597 |
PAK3 |
0.776 | -0.072 | -2 | 0.711 |
PRKX |
0.776 | -0.003 | -3 | 0.395 |
JNK2 |
0.776 | 0.024 | 1 | 0.611 |
PHKG1 |
0.776 | -0.083 | -3 | 0.495 |
CAMK1G |
0.775 | -0.047 | -3 | 0.483 |
CDK5 |
0.775 | -0.009 | 1 | 0.692 |
DYRK2 |
0.774 | -0.024 | 1 | 0.670 |
SGK3 |
0.774 | -0.043 | -3 | 0.463 |
PKCA |
0.774 | -0.055 | 2 | 0.660 |
CDK2 |
0.774 | -0.001 | 1 | 0.713 |
PKCG |
0.774 | -0.069 | 2 | 0.668 |
PKCH |
0.774 | -0.065 | 2 | 0.649 |
MEKK3 |
0.774 | -0.119 | 1 | 0.816 |
JNK3 |
0.774 | 0.001 | 1 | 0.646 |
MEKK1 |
0.773 | -0.106 | 1 | 0.836 |
ZAK |
0.773 | -0.083 | 1 | 0.809 |
PRP4 |
0.773 | -0.042 | -3 | 0.491 |
SNRK |
0.773 | -0.090 | 2 | 0.587 |
WNK4 |
0.773 | -0.061 | -2 | 0.785 |
CAMKK1 |
0.773 | -0.016 | -2 | 0.703 |
NEK8 |
0.772 | 0.016 | 2 | 0.729 |
CDK1 |
0.772 | -0.005 | 1 | 0.624 |
HIPK1 |
0.772 | -0.006 | 1 | 0.690 |
MAPKAPK5 |
0.772 | -0.093 | -3 | 0.443 |
CHK1 |
0.772 | -0.091 | -3 | 0.480 |
DAPK3 |
0.772 | 0.003 | -3 | 0.486 |
DRAK1 |
0.772 | -0.072 | 1 | 0.781 |
GAK |
0.772 | 0.022 | 1 | 0.845 |
MST3 |
0.772 | -0.039 | 2 | 0.761 |
DCAMKL1 |
0.772 | -0.073 | -3 | 0.470 |
PAK2 |
0.772 | -0.069 | -2 | 0.695 |
GRK2 |
0.771 | -0.071 | -2 | 0.704 |
MEKK2 |
0.771 | -0.106 | 2 | 0.725 |
PKG2 |
0.771 | -0.041 | -2 | 0.596 |
SMMLCK |
0.771 | -0.046 | -3 | 0.523 |
AKT1 |
0.770 | -0.016 | -3 | 0.435 |
MEK5 |
0.770 | -0.186 | 2 | 0.742 |
P38A |
0.770 | -0.022 | 1 | 0.666 |
CAMK1D |
0.769 | -0.039 | -3 | 0.401 |
MNK1 |
0.769 | -0.065 | -2 | 0.739 |
PHKG2 |
0.769 | -0.048 | -3 | 0.512 |
PKCZ |
0.769 | -0.098 | 2 | 0.700 |
CDK19 |
0.768 | -0.037 | 1 | 0.620 |
CK1E |
0.768 | -0.083 | -3 | 0.323 |
TAO3 |
0.768 | -0.093 | 1 | 0.822 |
TAK1 |
0.768 | 0.018 | 1 | 0.884 |
CK2A2 |
0.768 | 0.074 | 1 | 0.749 |
CDK7 |
0.767 | -0.056 | 1 | 0.673 |
P70S6K |
0.767 | -0.046 | -3 | 0.445 |
ERK2 |
0.767 | -0.033 | 1 | 0.645 |
NEK4 |
0.766 | 0.052 | 1 | 0.808 |
IRAK4 |
0.766 | -0.082 | 1 | 0.798 |
PASK |
0.766 | -0.073 | -3 | 0.513 |
PKACA |
0.766 | -0.025 | -2 | 0.562 |
P38B |
0.766 | -0.005 | 1 | 0.591 |
PLK4 |
0.766 | -0.114 | 2 | 0.514 |
HIPK2 |
0.765 | -0.015 | 1 | 0.585 |
LKB1 |
0.765 | -0.032 | -3 | 0.563 |
P38G |
0.765 | -0.015 | 1 | 0.531 |
CDK13 |
0.765 | -0.043 | 1 | 0.643 |
ERK1 |
0.764 | -0.023 | 1 | 0.586 |
TAO2 |
0.764 | -0.080 | 2 | 0.761 |
HIPK3 |
0.764 | -0.032 | 1 | 0.686 |
EEF2K |
0.764 | -0.008 | 3 | 0.813 |
DYRK1A |
0.764 | -0.050 | 1 | 0.734 |
MPSK1 |
0.764 | -0.037 | 1 | 0.786 |
DCAMKL2 |
0.763 | -0.086 | -3 | 0.506 |
CK1D |
0.763 | -0.082 | -3 | 0.290 |
PKCT |
0.763 | -0.069 | 2 | 0.656 |
DAPK1 |
0.762 | -0.021 | -3 | 0.481 |
CDK18 |
0.762 | -0.035 | 1 | 0.593 |
CDK16 |
0.762 | 0.011 | 1 | 0.567 |
CAMKK2 |
0.761 | -0.083 | -2 | 0.693 |
MST2 |
0.761 | -0.082 | 1 | 0.833 |
TNIK |
0.761 | -0.025 | 3 | 0.830 |
ERK7 |
0.761 | 0.008 | 2 | 0.530 |
NEK1 |
0.761 | 0.063 | 1 | 0.813 |
PLK2 |
0.761 | -0.024 | -3 | 0.494 |
DYRK4 |
0.760 | -0.007 | 1 | 0.600 |
MRCKB |
0.760 | -0.011 | -3 | 0.458 |
CDK3 |
0.760 | 0.014 | 1 | 0.561 |
MINK |
0.760 | -0.047 | 1 | 0.811 |
IRAK1 |
0.760 | -0.127 | -1 | 0.709 |
PKCI |
0.760 | -0.047 | 2 | 0.670 |
NEK11 |
0.760 | -0.132 | 1 | 0.813 |
DYRK3 |
0.759 | -0.025 | 1 | 0.687 |
SGK1 |
0.759 | -0.027 | -3 | 0.360 |
CHK2 |
0.759 | -0.057 | -3 | 0.393 |
DYRK1B |
0.759 | -0.022 | 1 | 0.626 |
CDK9 |
0.759 | -0.049 | 1 | 0.645 |
MRCKA |
0.758 | -0.014 | -3 | 0.458 |
GCK |
0.758 | -0.088 | 1 | 0.823 |
CDK17 |
0.758 | -0.034 | 1 | 0.544 |
HGK |
0.758 | -0.055 | 3 | 0.830 |
TTBK1 |
0.758 | -0.105 | 2 | 0.526 |
GRK3 |
0.758 | -0.075 | -2 | 0.673 |
CK1A2 |
0.758 | -0.092 | -3 | 0.291 |
MEKK6 |
0.757 | -0.086 | 1 | 0.803 |
CAMK1A |
0.757 | -0.042 | -3 | 0.400 |
CK2A1 |
0.757 | 0.050 | 1 | 0.722 |
AKT3 |
0.757 | -0.027 | -3 | 0.373 |
GSK3A |
0.757 | -0.052 | 4 | 0.363 |
PKCE |
0.756 | -0.039 | 2 | 0.649 |
CDK10 |
0.756 | -0.005 | 1 | 0.624 |
CDK12 |
0.756 | -0.051 | 1 | 0.613 |
GSK3B |
0.755 | -0.069 | 4 | 0.353 |
CDK14 |
0.755 | -0.029 | 1 | 0.642 |
P38D |
0.755 | -0.008 | 1 | 0.554 |
DMPK1 |
0.755 | 0.009 | -3 | 0.477 |
PDK1 |
0.754 | -0.122 | 1 | 0.802 |
PAK5 |
0.754 | -0.039 | -2 | 0.576 |
MST1 |
0.754 | -0.089 | 1 | 0.811 |
MEK2 |
0.754 | -0.067 | 2 | 0.720 |
ROCK2 |
0.754 | -0.025 | -3 | 0.470 |
HPK1 |
0.753 | -0.071 | 1 | 0.802 |
MAP3K15 |
0.753 | -0.119 | 1 | 0.790 |
CK1G1 |
0.753 | -0.117 | -3 | 0.310 |
LRRK2 |
0.753 | -0.133 | 2 | 0.757 |
LOK |
0.752 | -0.085 | -2 | 0.699 |
PKN1 |
0.752 | -0.067 | -3 | 0.461 |
KHS2 |
0.752 | -0.032 | 1 | 0.815 |
PDHK3_TYR |
0.751 | 0.064 | 4 | 0.794 |
VRK1 |
0.750 | -0.152 | 2 | 0.723 |
YSK1 |
0.749 | -0.065 | 2 | 0.732 |
KHS1 |
0.749 | -0.059 | 1 | 0.799 |
PAK4 |
0.749 | -0.033 | -2 | 0.594 |
CDK6 |
0.749 | -0.008 | 1 | 0.618 |
JNK1 |
0.748 | -0.024 | 1 | 0.604 |
STK33 |
0.748 | -0.076 | 2 | 0.523 |
TTK |
0.748 | -0.028 | -2 | 0.843 |
MOK |
0.748 | -0.014 | 1 | 0.670 |
RIPK2 |
0.747 | -0.107 | 1 | 0.768 |
NEK3 |
0.747 | -0.027 | 1 | 0.764 |
SBK |
0.747 | -0.058 | -3 | 0.348 |
PDHK4_TYR |
0.746 | 0.032 | 2 | 0.813 |
ROCK1 |
0.746 | -0.017 | -3 | 0.458 |
CDK4 |
0.745 | -0.022 | 1 | 0.605 |
CRIK |
0.745 | -0.017 | -3 | 0.424 |
SLK |
0.745 | -0.121 | -2 | 0.647 |
OSR1 |
0.745 | -0.087 | 2 | 0.720 |
MAK |
0.744 | -0.036 | -2 | 0.630 |
EPHA6 |
0.743 | 0.065 | -1 | 0.836 |
BUB1 |
0.742 | -0.048 | -5 | 0.724 |
MAP2K6_TYR |
0.742 | -0.043 | -1 | 0.831 |
TESK1_TYR |
0.741 | -0.077 | 3 | 0.864 |
PDHK1_TYR |
0.741 | -0.016 | -1 | 0.848 |
BMPR2_TYR |
0.741 | -0.023 | -1 | 0.832 |
PBK |
0.741 | -0.061 | 1 | 0.746 |
MAP2K4_TYR |
0.740 | -0.078 | -1 | 0.824 |
BIKE |
0.739 | -0.002 | 1 | 0.707 |
PINK1_TYR |
0.739 | -0.081 | 1 | 0.863 |
MAP2K7_TYR |
0.739 | -0.147 | 2 | 0.777 |
HASPIN |
0.738 | -0.028 | -1 | 0.668 |
MYO3B |
0.737 | -0.052 | 2 | 0.742 |
ALPHAK3 |
0.737 | -0.059 | -1 | 0.737 |
ASK1 |
0.735 | -0.107 | 1 | 0.786 |
PKMYT1_TYR |
0.734 | -0.145 | 3 | 0.828 |
PKG1 |
0.734 | -0.068 | -2 | 0.512 |
MYO3A |
0.733 | -0.083 | 1 | 0.797 |
RET |
0.733 | -0.095 | 1 | 0.827 |
TXK |
0.733 | 0.030 | 1 | 0.853 |
LIMK2_TYR |
0.731 | -0.089 | -3 | 0.576 |
EPHB4 |
0.731 | -0.020 | -1 | 0.807 |
TAO1 |
0.731 | -0.107 | 1 | 0.749 |
FER |
0.730 | -0.021 | 1 | 0.904 |
EPHA4 |
0.730 | 0.027 | 2 | 0.702 |
YES1 |
0.730 | -0.023 | -1 | 0.796 |
TYK2 |
0.730 | -0.083 | 1 | 0.826 |
BLK |
0.730 | 0.050 | -1 | 0.813 |
LCK |
0.728 | 0.016 | -1 | 0.793 |
ROS1 |
0.728 | -0.085 | 3 | 0.758 |
ABL2 |
0.728 | -0.037 | -1 | 0.787 |
LIMK1_TYR |
0.727 | -0.158 | 2 | 0.761 |
HCK |
0.727 | -0.001 | -1 | 0.794 |
MST1R |
0.727 | -0.111 | 3 | 0.774 |
TYRO3 |
0.727 | -0.110 | 3 | 0.783 |
SRMS |
0.726 | -0.009 | 1 | 0.885 |
EPHB2 |
0.726 | 0.025 | -1 | 0.795 |
YANK3 |
0.726 | -0.092 | 2 | 0.338 |
FGR |
0.726 | -0.083 | 1 | 0.845 |
EPHB1 |
0.726 | 0.004 | 1 | 0.869 |
JAK2 |
0.725 | -0.100 | 1 | 0.819 |
ITK |
0.725 | -0.035 | -1 | 0.767 |
TEC |
0.725 | 0.021 | -1 | 0.721 |
STLK3 |
0.725 | -0.140 | 1 | 0.785 |
CSF1R |
0.725 | -0.099 | 3 | 0.765 |
INSRR |
0.725 | -0.064 | 3 | 0.735 |
FLT3 |
0.724 | -0.052 | 3 | 0.774 |
JAK3 |
0.724 | -0.100 | 1 | 0.808 |
EPHB3 |
0.723 | -0.009 | -1 | 0.794 |
DDR1 |
0.723 | -0.141 | 4 | 0.740 |
ABL1 |
0.721 | -0.060 | -1 | 0.779 |
NEK10_TYR |
0.721 | -0.047 | 1 | 0.722 |
CK1A |
0.721 | -0.109 | -3 | 0.226 |
AAK1 |
0.720 | 0.012 | 1 | 0.589 |
FGFR2 |
0.720 | -0.101 | 3 | 0.773 |
BMX |
0.719 | -0.030 | -1 | 0.696 |
TEK |
0.719 | -0.072 | 3 | 0.735 |
KIT |
0.719 | -0.106 | 3 | 0.772 |
KDR |
0.719 | -0.090 | 3 | 0.728 |
FYN |
0.719 | 0.003 | -1 | 0.766 |
TNNI3K_TYR |
0.719 | -0.046 | 1 | 0.801 |
TNK2 |
0.719 | -0.066 | 3 | 0.737 |
PDGFRB |
0.718 | -0.127 | 3 | 0.783 |
BTK |
0.718 | -0.064 | -1 | 0.729 |
EPHA7 |
0.718 | -0.006 | 2 | 0.691 |
FRK |
0.716 | -0.020 | -1 | 0.830 |
MERTK |
0.715 | -0.065 | 3 | 0.751 |
LYN |
0.715 | -0.024 | 3 | 0.696 |
FGFR1 |
0.715 | -0.122 | 3 | 0.753 |
CK1G3 |
0.714 | -0.098 | -3 | 0.194 |
JAK1 |
0.714 | -0.060 | 1 | 0.763 |
ERBB2 |
0.714 | -0.088 | 1 | 0.799 |
MET |
0.714 | -0.115 | 3 | 0.755 |
EPHA5 |
0.713 | 0.004 | 2 | 0.692 |
FLT1 |
0.713 | -0.093 | -1 | 0.810 |
EPHA3 |
0.713 | -0.061 | 2 | 0.669 |
ALK |
0.712 | -0.091 | 3 | 0.713 |
WEE1_TYR |
0.711 | -0.079 | -1 | 0.675 |
AXL |
0.711 | -0.123 | 3 | 0.752 |
LTK |
0.711 | -0.080 | 3 | 0.729 |
PDGFRA |
0.710 | -0.154 | 3 | 0.779 |
TNK1 |
0.710 | -0.131 | 3 | 0.761 |
PTK6 |
0.709 | -0.129 | -1 | 0.677 |
EPHA1 |
0.709 | -0.066 | 3 | 0.734 |
FGFR3 |
0.709 | -0.117 | 3 | 0.745 |
SYK |
0.709 | 0.011 | -1 | 0.755 |
EPHA8 |
0.708 | -0.041 | -1 | 0.784 |
PTK2 |
0.707 | -0.005 | -1 | 0.776 |
FLT4 |
0.706 | -0.124 | 3 | 0.726 |
EGFR |
0.706 | -0.056 | 1 | 0.712 |
SRC |
0.705 | -0.057 | -1 | 0.765 |
MATK |
0.705 | -0.106 | -1 | 0.710 |
NTRK1 |
0.705 | -0.163 | -1 | 0.762 |
INSR |
0.704 | -0.125 | 3 | 0.706 |
PTK2B |
0.704 | -0.059 | -1 | 0.745 |
NTRK2 |
0.702 | -0.157 | 3 | 0.720 |
DDR2 |
0.700 | -0.118 | 3 | 0.724 |
EPHA2 |
0.699 | -0.034 | -1 | 0.755 |
YANK2 |
0.698 | -0.106 | 2 | 0.362 |
NTRK3 |
0.697 | -0.146 | -1 | 0.711 |
FGFR4 |
0.697 | -0.103 | -1 | 0.735 |
CSK |
0.697 | -0.132 | 2 | 0.694 |
ERBB4 |
0.696 | -0.038 | 1 | 0.729 |
CK1G2 |
0.693 | -0.093 | -3 | 0.258 |
IGF1R |
0.691 | -0.112 | 3 | 0.656 |
MUSK |
0.688 | -0.109 | 1 | 0.684 |
FES |
0.679 | -0.110 | -1 | 0.662 |
ZAP70 |
0.678 | -0.069 | -1 | 0.668 |