Motif 613 (n=149)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NFI3 | ZNF316 | S105 | ochoa | Zinc finger protein 316 | May be involved in transcriptional regulation. {ECO:0000250}. |
| B5ME19 | EIF3CL | S531 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| O14713 | ITGB1BP1 | S50 | ochoa | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O14879 | IFIT3 | S270 | ochoa | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}. |
| O15327 | INPP4B | S549 | ochoa | Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}. |
| O43290 | SART1 | S84 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43491 | EPB41L2 | S627 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43781 | DYRK3 | S350 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| O43823 | AKAP8 | S353 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60313 | OPA1 | S478 | ochoa | Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] | Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28628083, PubMed:28746876, PubMed:31922487, PubMed:32228866, PubMed:32567732, PubMed:33130824, PubMed:33237841, PubMed:37612504, PubMed:37612506). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:31922487, PubMed:32228866, PubMed:33237841, PubMed:37612504, PubMed:37612506). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:31922487, PubMed:37612504, PubMed:37612506). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:20038677, PubMed:31922487). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Involved in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (PubMed:18158317, PubMed:20974897). {ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:17709429, ECO:0000269|PubMed:18158317, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:20185555, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:24616225, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:28746876, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:33237841, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, long form]: Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32567732, PubMed:33130824). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, short form]: Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:32245890, PubMed:37612504, PubMed:37612506). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:32228866, PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (PubMed:20038677). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32245890). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32245890, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Isoform 1]: Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. {ECO:0000269|PubMed:17709429}.; FUNCTION: [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}.; FUNCTION: [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}. |
| O60343 | TBC1D4 | S485 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60841 | EIF5B | S66 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60890 | OPHN1 | S372 | ochoa | Oligophrenin-1 | Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}. |
| O75069 | TMCC2 | S438 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75334 | PPFIA2 | S263 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
| O75962 | TRIO | S2631 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94876 | TMCC1 | S382 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
| O94986 | CEP152 | S1430 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O94992 | HEXIM1 | S283 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95613 | PCNT | S2477 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95936 | EOMES | S596 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| P04792 | HSPB1 | S98 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05114 | HMGN1 | S21 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P05976 | MYL1 | S68 | ochoa | Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2) | Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}. |
| P07195 | LDHB | S303 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07900 | HSP90AA1 | S641 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08708 | RPS17 | S115 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P11055 | MYH3 | S174 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11831 | SRF | S253 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12882 | MYH1 | S174 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S173 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1435 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12956 | XRCC6 | S222 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13010 | XRCC5 | S258 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13533 | MYH6 | S173 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1437 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S176 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P16157 | ANK1 | S759 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P18583 | SON | S90 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19338 | NCL | S608 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20810 | CAST | S311 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21817 | RYR1 | S1337 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P27694 | RPA1 | S315 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P29374 | ARID4A | S840 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P33981 | TTK | S582 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | S1660 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | S411 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35609 | ACTN2 | S624 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S1667 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1720 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P39023 | RPL3 | S372 | ochoa | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P41743 | PRKCI | S411 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P46100 | ATRX | S1236 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P48681 | NES | S320 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P50570 | DNM2 | S644 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P51955 | NEK2 | S365 | ochoa|psp | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52565 | ARHGDIA | S34 | ochoa|psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52566 | ARHGDIB | S31 | ochoa|psp | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P55197 | MLLT10 | S302 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P60484 | PTEN | S302 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P61247 | RPS3A | S112 | psp | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P63104 | YWHAZ | S28 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| Q01082 | SPTBN1 | S768 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01082 | SPTBN1 | S2041 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q12923 | PTPN13 | S240 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13557 | CAMK2D | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13769 | THOC5 | S307 | ochoa|psp | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q13813 | SPTAN1 | S1476 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14134 | TRIM29 | S256 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14254 | FLOT2 | S405 | ochoa | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Q14573 | ITPR3 | S954 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14644 | RASA3 | S207 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14BN4 | SLMAP | S402 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q14BN4 | SLMAP | S480 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q15057 | ACAP2 | S381 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15283 | RASA2 | S234 | ochoa | Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). |
| Q15459 | SF3A1 | S451 | ochoa | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
| Q15772 | SPEG | S2322 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16849 | PTPRN | S303 | ochoa | Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] | Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}. |
| Q5M775 | SPECC1 | S692 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T7W0 | ZNF618 | S216 | ochoa | Zinc finger protein 618 | Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}. |
| Q5T8I3 | EEIG2 | S313 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5TAP6 | UTP14C | S28 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
| Q5THJ4 | VPS13D | S1065 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q6NZY4 | ZCCHC8 | S573 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6PJ69 | TRIM65 | S167 | psp | E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) | E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252). This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402). Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:31160576, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:33373584, ECO:0000269|PubMed:34512673}. |
| Q6PKG0 | LARP1 | S492 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZUJ8 | PIK3AP1 | S562 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7L591 | DOK3 | S383 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q8N1G1 | REXO1 | S499 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N4C6 | NIN | S1540 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5A5 | ZGPAT | S56 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8NI35 | PATJ | S806 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TDY2 | RB1CC1 | S1051 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WUM0 | NUP133 | S493 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVV4 | POF1B | S156 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q92545 | TMEM131 | S1423 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92547 | TOPBP1 | S853 | ochoa|psp | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92901 | RPL3L | S372 | ochoa | Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like) | Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function. {ECO:0000250|UniProtKB:E9PWZ3}. |
| Q96KQ7 | EHMT2 | S237 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96RS0 | TGS1 | S158 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96T37 | RBM15 | S179 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99613 | EIF3C | S530 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q9BVJ6 | UTP14A | S29 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW71 | HIRIP3 | S372 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXK5 | BCL2L13 | S353 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BYW2 | SETD2 | S717 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9HAW4 | CLSPN | S950 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9P0U3 | SENP1 | S416 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9UGL1 | KDM5B | S986 | ochoa | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UGU5 | HMGXB4 | S197 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UH62 | ARMCX3 | S288 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UKL3 | CASP8AP2 | S940 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S174 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULH0 | KIDINS220 | S1621 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULS5 | TMCC3 | S216 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UPA5 | BSN | S1104 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPN4 | CEP131 | S745 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y2W1 | THRAP3 | S877 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y485 | DMXL1 | S2381 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y623 | MYH4 | S174 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P05023 | ATP1A1 | S757 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P13637 | ATP1A3 | S747 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P50993 | ATP1A2 | S754 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| Q12931 | TRAP1 | S482 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13733 | ATP1A4 | S763 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. |
| Q14204 | DYNC1H1 | S1313 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q9NP74 | PALMD | S199 | Sugiyama | Palmdelphin (Paralemmin-like protein) | None |
| P35579 | MYH9 | S169 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q96CW6 | SLC7A6OS | S32 | Sugiyama | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| O43615 | TIMM44 | Y104 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| Q15398 | DLGAP5 | S67 | GPS6|EPSD | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| P11362 | FGFR1 | S602 | Sugiyama | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P22607 | FGFR3 | S596 | Sugiyama | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
| Q9H0C2 | SLC25A31 | S286 | Sugiyama | ADP/ATP translocase 4 (ADP,ATP carrier protein 4) (Adenine nucleotide translocator 4) (ANT 4) (Solute carrier family 25 member 31) (Sperm flagellar energy carrier protein) | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity) (PubMed:15670820). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed:17137571). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (PubMed:15670820). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000250|UniProtKB:Q3V132, ECO:0000269|PubMed:15670820, ECO:0000269|PubMed:17137571}. |
| P14625 | HSP90B1 | S544 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P35580 | MYH10 | S1699 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P78362 | SRPK2 | S114 | Sugiyama | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| Q01082 | SPTBN1 | S446 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02763 | TEK | S862 | Sugiyama | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) | Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}. |
| Q14164 | IKBKE | S151 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q01082 | SPTBN1 | S2048 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q86UE8 | TLK2 | S307 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q9NUU7 | DDX19A | S444 | Sugiyama | ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}. |
| Q9UMR2 | DDX19B | S445 | Sugiyama | ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) | ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}. |
| Q01581 | HMGCS1 | S83 | Sugiyama | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| P35580 | MYH10 | S173 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35749 | MYH11 | S173 | Sugiyama | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| Q7Z406 | MYH14 | S193 | Sugiyama | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-397014 | Muscle contraction | 9.332929e-07 | 6.030 |
| R-HSA-5578775 | Ion homeostasis | 5.053093e-06 | 5.296 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.748377e-05 | 4.561 |
| R-HSA-390522 | Striated Muscle Contraction | 6.333947e-05 | 4.198 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 9.989056e-05 | 4.000 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 9.989056e-05 | 4.000 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.248857e-04 | 3.903 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.840284e-05 | 4.054 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.088365e-04 | 3.963 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.384516e-04 | 3.859 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.026424e-04 | 3.693 |
| R-HSA-380287 | Centrosome maturation | 2.307089e-04 | 3.637 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.163171e-04 | 3.665 |
| R-HSA-422475 | Axon guidance | 2.419912e-04 | 3.616 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.122046e-04 | 3.506 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.970455e-04 | 3.401 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.946464e-04 | 3.404 |
| R-HSA-9675108 | Nervous system development | 4.824509e-04 | 3.317 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.232598e-04 | 3.281 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.816899e-04 | 3.235 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 7.479521e-04 | 3.126 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 7.479521e-04 | 3.126 |
| R-HSA-5576891 | Cardiac conduction | 8.453896e-04 | 3.073 |
| R-HSA-373755 | Semaphorin interactions | 8.671350e-04 | 3.062 |
| R-HSA-936837 | Ion transport by P-type ATPases | 9.224327e-04 | 3.035 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 1.246215e-03 | 2.904 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.310949e-03 | 2.882 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.550377e-03 | 2.810 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.307463e-03 | 2.637 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.307463e-03 | 2.637 |
| R-HSA-373753 | Nephrin family interactions | 2.241538e-03 | 2.649 |
| R-HSA-9679506 | SARS-CoV Infections | 2.445692e-03 | 2.612 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.487427e-03 | 2.604 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.782163e-03 | 2.556 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.782163e-03 | 2.556 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.782163e-03 | 2.556 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 3.127088e-03 | 2.505 |
| R-HSA-109704 | PI3K Cascade | 3.095415e-03 | 2.509 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.452430e-03 | 2.462 |
| R-HSA-9620244 | Long-term potentiation | 4.088135e-03 | 2.388 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.926311e-03 | 2.406 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.130061e-03 | 2.384 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.155462e-03 | 2.381 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.859211e-03 | 2.313 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.859211e-03 | 2.313 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.847277e-03 | 2.315 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.478443e-03 | 2.349 |
| R-HSA-112399 | IRS-mediated signalling | 4.623182e-03 | 2.335 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.615614e-03 | 2.251 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.690555e-03 | 2.245 |
| R-HSA-68877 | Mitotic Prometaphase | 6.365750e-03 | 2.196 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.591026e-03 | 2.181 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.591026e-03 | 2.181 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.910959e-03 | 2.160 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 7.673739e-03 | 2.115 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.673739e-03 | 2.115 |
| R-HSA-9733709 | Cardiogenesis | 7.673739e-03 | 2.115 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.862733e-03 | 2.104 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.931945e-03 | 2.101 |
| R-HSA-164843 | 2-LTR circle formation | 7.987397e-03 | 2.098 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 7.987397e-03 | 2.098 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.054263e-03 | 2.094 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.999153e-03 | 2.046 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.173882e-03 | 2.037 |
| R-HSA-3371511 | HSF1 activation | 9.987186e-03 | 2.001 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.049400e-02 | 1.979 |
| R-HSA-162592 | Integration of provirus | 1.049400e-02 | 1.979 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.049400e-02 | 1.979 |
| R-HSA-373760 | L1CAM interactions | 1.109295e-02 | 1.955 |
| R-HSA-9646399 | Aggrephagy | 1.266431e-02 | 1.897 |
| R-HSA-9659379 | Sensory processing of sound | 1.250772e-02 | 1.903 |
| R-HSA-3371556 | Cellular response to heat stress | 1.287175e-02 | 1.890 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.481429e-02 | 1.829 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.491600e-02 | 1.826 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.414200e-02 | 1.849 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.363431e-02 | 1.865 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.330165e-02 | 1.876 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.414200e-02 | 1.849 |
| R-HSA-9824446 | Viral Infection Pathways | 1.333248e-02 | 1.875 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.388453e-02 | 1.857 |
| R-HSA-72312 | rRNA processing | 1.530846e-02 | 1.815 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.601923e-02 | 1.795 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 1.639735e-02 | 1.785 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.639735e-02 | 1.785 |
| R-HSA-168255 | Influenza Infection | 1.648955e-02 | 1.783 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.016407e-02 | 1.695 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.016407e-02 | 1.695 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.016407e-02 | 1.695 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.016407e-02 | 1.695 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.016407e-02 | 1.695 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.974823e-02 | 1.704 |
| R-HSA-156902 | Peptide chain elongation | 1.789174e-02 | 1.747 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.824817e-02 | 1.739 |
| R-HSA-69275 | G2/M Transition | 1.918588e-02 | 1.717 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.000844e-02 | 1.699 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.737958e-02 | 1.760 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.039249e-02 | 1.691 |
| R-HSA-983712 | Ion channel transport | 2.042859e-02 | 1.690 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 2.155350e-02 | 1.666 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.309832e-02 | 1.636 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 2.340282e-02 | 1.631 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.340282e-02 | 1.631 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.294828e-02 | 1.639 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.380725e-02 | 1.623 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.452927e-02 | 1.610 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.104957e-02 | 1.677 |
| R-HSA-5617833 | Cilium Assembly | 2.085471e-02 | 1.681 |
| R-HSA-162582 | Signal Transduction | 2.149145e-02 | 1.668 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.104957e-02 | 1.677 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.455180e-02 | 1.610 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.531498e-02 | 1.597 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.531498e-02 | 1.597 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.531498e-02 | 1.597 |
| R-HSA-190236 | Signaling by FGFR | 2.601279e-02 | 1.585 |
| R-HSA-72649 | Translation initiation complex formation | 2.605449e-02 | 1.584 |
| R-HSA-2033515 | t(4;14) translocations of FGFR3 | 3.009404e-02 | 1.522 |
| R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 3.009404e-02 | 1.522 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 3.009404e-02 | 1.522 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.932202e-02 | 1.533 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 3.141409e-02 | 1.503 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.824434e-02 | 1.549 |
| R-HSA-192823 | Viral mRNA Translation | 2.995367e-02 | 1.524 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.052909e-02 | 1.515 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.833735e-02 | 1.548 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.078192e-02 | 1.512 |
| R-HSA-8953854 | Metabolism of RNA | 2.916263e-02 | 1.535 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.152218e-02 | 1.501 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.824434e-02 | 1.549 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.677436e-02 | 1.572 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.932202e-02 | 1.533 |
| R-HSA-73887 | Death Receptor Signaling | 3.219894e-02 | 1.492 |
| R-HSA-1483255 | PI Metabolism | 2.913883e-02 | 1.536 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.334731e-02 | 1.477 |
| R-HSA-5357801 | Programmed Cell Death | 2.851089e-02 | 1.545 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.356333e-02 | 1.474 |
| R-HSA-112043 | PLC beta mediated events | 3.413327e-02 | 1.467 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.422939e-02 | 1.466 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.538161e-02 | 1.451 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.538161e-02 | 1.451 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.576840e-02 | 1.447 |
| R-HSA-1640170 | Cell Cycle | 3.632355e-02 | 1.440 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.665330e-02 | 1.436 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 3.802795e-02 | 1.420 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.884276e-02 | 1.411 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.884276e-02 | 1.411 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.992398e-02 | 1.399 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.992398e-02 | 1.399 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.992398e-02 | 1.399 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.992398e-02 | 1.399 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.992398e-02 | 1.399 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.992398e-02 | 1.399 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.992398e-02 | 1.399 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.992398e-02 | 1.399 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.992398e-02 | 1.399 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.992398e-02 | 1.399 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.992398e-02 | 1.399 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 4.965490e-02 | 1.304 |
| R-HSA-209563 | Axonal growth stimulation | 4.965490e-02 | 1.304 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 4.034068e-02 | 1.394 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 5.009766e-02 | 1.300 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 5.009766e-02 | 1.300 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.512047e-02 | 1.346 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.765589e-02 | 1.322 |
| R-HSA-420029 | Tight junction interactions | 4.034068e-02 | 1.394 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.063278e-02 | 1.296 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.758501e-02 | 1.323 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.277750e-02 | 1.369 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.215448e-02 | 1.283 |
| R-HSA-112040 | G-protein mediated events | 4.197173e-02 | 1.377 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 5.265721e-02 | 1.279 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.265721e-02 | 1.279 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.526366e-02 | 1.258 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.791223e-02 | 1.237 |
| R-HSA-69481 | G2/M Checkpoints | 5.825363e-02 | 1.235 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.845959e-02 | 1.233 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.928778e-02 | 1.227 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.928778e-02 | 1.227 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.008971e-02 | 1.221 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.042149e-02 | 1.219 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 6.060537e-02 | 1.217 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 6.060537e-02 | 1.217 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 6.060537e-02 | 1.217 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 6.060537e-02 | 1.217 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.341347e-02 | 1.198 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 6.611722e-02 | 1.180 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.611722e-02 | 1.180 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.611722e-02 | 1.180 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.611722e-02 | 1.180 |
| R-HSA-1266738 | Developmental Biology | 6.615151e-02 | 1.179 |
| R-HSA-1643685 | Disease | 6.742454e-02 | 1.171 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 6.882362e-02 | 1.162 |
| R-HSA-8948747 | Regulation of PTEN localization | 9.685848e-02 | 1.014 |
| R-HSA-190371 | FGFR3b ligand binding and activation | 9.685848e-02 | 1.014 |
| R-HSA-1989781 | PPARA activates gene expression | 1.016162e-01 | 0.993 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 6.893370e-02 | 1.162 |
| R-HSA-3371568 | Attenuation phase | 8.357886e-02 | 1.078 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.495839e-02 | 1.125 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 9.685848e-02 | 1.014 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.022576e-01 | 0.990 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 7.761243e-02 | 1.110 |
| R-HSA-447043 | Neurofascin interactions | 8.760801e-02 | 1.057 |
| R-HSA-1632852 | Macroautophagy | 7.912349e-02 | 1.102 |
| R-HSA-447038 | NrCAM interactions | 6.882362e-02 | 1.162 |
| R-HSA-9663891 | Selective autophagy | 7.753058e-02 | 1.111 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 9.685848e-02 | 1.014 |
| R-HSA-447041 | CHL1 interactions | 9.685848e-02 | 1.014 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.569585e-02 | 1.121 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.928022e-02 | 1.049 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 9.685848e-02 | 1.014 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.893370e-02 | 1.162 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 7.761243e-02 | 1.110 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 8.661322e-02 | 1.062 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.196331e-02 | 1.086 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.031038e-02 | 1.153 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.761243e-02 | 1.110 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.690122e-02 | 1.014 |
| R-HSA-111933 | Calmodulin induced events | 7.178910e-02 | 1.144 |
| R-HSA-111997 | CaM pathway | 7.178910e-02 | 1.144 |
| R-HSA-111996 | Ca-dependent events | 9.277929e-02 | 1.033 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 8.315088e-02 | 1.080 |
| R-HSA-5663205 | Infectious disease | 1.028030e-01 | 0.988 |
| R-HSA-9612973 | Autophagy | 1.032112e-01 | 0.986 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.048176e-01 | 0.980 |
| R-HSA-75153 | Apoptotic execution phase | 1.054744e-01 | 0.977 |
| R-HSA-9675135 | Diseases of DNA repair | 1.054744e-01 | 0.977 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 1.060157e-01 | 0.975 |
| R-HSA-196025 | Formation of annular gap junctions | 1.060157e-01 | 0.975 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.060157e-01 | 0.975 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.060157e-01 | 0.975 |
| R-HSA-9711097 | Cellular response to starvation | 1.064355e-01 | 0.973 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.072798e-01 | 0.969 |
| R-HSA-170984 | ARMS-mediated activation | 1.150807e-01 | 0.939 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.504360e-01 | 0.823 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.843870e-01 | 0.734 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.926619e-01 | 0.715 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.008534e-01 | 0.697 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.008534e-01 | 0.697 |
| R-HSA-210993 | Tie2 Signaling | 2.089622e-01 | 0.680 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.089622e-01 | 0.680 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.253170e-01 | 0.902 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.287065e-01 | 0.890 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.000385e-01 | 0.699 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.817081e-01 | 0.741 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.529902e-01 | 0.815 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.760279e-01 | 0.754 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.119889e-01 | 0.951 |
| R-HSA-190873 | Gap junction degradation | 1.150807e-01 | 0.939 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.675835e-01 | 0.776 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.008534e-01 | 0.697 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.169892e-01 | 0.664 |
| R-HSA-6807070 | PTEN Regulation | 2.132245e-01 | 0.671 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.390005e-01 | 0.857 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.590532e-01 | 0.798 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.329374e-01 | 0.876 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.150807e-01 | 0.939 |
| R-HSA-192905 | vRNP Assembly | 1.329374e-01 | 0.876 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.504360e-01 | 0.823 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 1.675835e-01 | 0.776 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.089622e-01 | 0.680 |
| R-HSA-191859 | snRNP Assembly | 1.494667e-01 | 0.825 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.494667e-01 | 0.825 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.926619e-01 | 0.715 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.150807e-01 | 0.939 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.760279e-01 | 0.754 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.760279e-01 | 0.754 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.760279e-01 | 0.754 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.186053e-01 | 0.926 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.417310e-01 | 0.849 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.417310e-01 | 0.849 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.675835e-01 | 0.776 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.675835e-01 | 0.776 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.760279e-01 | 0.754 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.926619e-01 | 0.715 |
| R-HSA-169893 | Prolonged ERK activation events | 1.843870e-01 | 0.734 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.504360e-01 | 0.823 |
| R-HSA-392517 | Rap1 signalling | 2.169892e-01 | 0.664 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.094025e-01 | 0.961 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.384000e-01 | 0.859 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.089622e-01 | 0.680 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.454323e-01 | 0.837 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.240543e-01 | 0.906 |
| R-HSA-5693538 | Homology Directed Repair | 1.525800e-01 | 0.817 |
| R-HSA-194138 | Signaling by VEGF | 1.721606e-01 | 0.764 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.094025e-01 | 0.961 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.150807e-01 | 0.939 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.008534e-01 | 0.697 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.119889e-01 | 0.951 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.150807e-01 | 0.939 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.150807e-01 | 0.939 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.590532e-01 | 0.798 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.760279e-01 | 0.754 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.843870e-01 | 0.734 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.008534e-01 | 0.697 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.008534e-01 | 0.697 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.074324e-01 | 0.683 |
| R-HSA-68886 | M Phase | 1.191806e-01 | 0.924 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.008534e-01 | 0.697 |
| R-HSA-5358508 | Mismatch Repair | 2.089622e-01 | 0.680 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.337788e-01 | 0.874 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.843870e-01 | 0.734 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.321175e-01 | 0.879 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.963537e-01 | 0.707 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.796818e-01 | 0.745 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.760279e-01 | 0.754 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.390005e-01 | 0.857 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.926777e-01 | 0.715 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.146205e-01 | 0.941 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.089622e-01 | 0.680 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.636558e-01 | 0.786 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.185036e-01 | 0.661 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.356115e-01 | 0.868 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.963537e-01 | 0.707 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.329374e-01 | 0.876 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.504360e-01 | 0.823 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.150807e-01 | 0.939 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.896757e-01 | 0.722 |
| R-HSA-2262752 | Cellular responses to stress | 1.099356e-01 | 0.959 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.089622e-01 | 0.680 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.780729e-01 | 0.749 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.383691e-01 | 0.859 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.454323e-01 | 0.837 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.760279e-01 | 0.754 |
| R-HSA-5218859 | Regulated Necrosis | 1.817081e-01 | 0.741 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.169892e-01 | 0.664 |
| R-HSA-111885 | Opioid Signalling | 1.136966e-01 | 0.944 |
| R-HSA-913531 | Interferon Signaling | 1.202939e-01 | 0.920 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.163789e-01 | 0.934 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.000385e-01 | 0.699 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.355491e-01 | 0.868 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.008534e-01 | 0.697 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.890110e-01 | 0.724 |
| R-HSA-109581 | Apoptosis | 1.130201e-01 | 0.947 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.917234e-01 | 0.717 |
| R-HSA-1500931 | Cell-Cell communication | 1.301126e-01 | 0.886 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.374212e-01 | 0.862 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.185756e-01 | 0.660 |
| R-HSA-1483257 | Phospholipid metabolism | 2.194219e-01 | 0.659 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.249353e-01 | 0.648 |
| R-HSA-445144 | Signal transduction by L1 | 2.249353e-01 | 0.648 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.260335e-01 | 0.646 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.266560e-01 | 0.645 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.281320e-01 | 0.642 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.328012e-01 | 0.633 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.328012e-01 | 0.633 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.328012e-01 | 0.633 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.328012e-01 | 0.633 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.328012e-01 | 0.633 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.328012e-01 | 0.633 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.335100e-01 | 0.632 |
| R-HSA-166520 | Signaling by NTRKs | 2.398756e-01 | 0.620 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.405878e-01 | 0.619 |
| R-HSA-9758941 | Gastrulation | 2.425726e-01 | 0.615 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.447516e-01 | 0.611 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.482959e-01 | 0.605 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.485041e-01 | 0.605 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.485041e-01 | 0.605 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.503912e-01 | 0.601 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.522586e-01 | 0.598 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.559261e-01 | 0.592 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.604184e-01 | 0.584 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.634794e-01 | 0.579 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.634794e-01 | 0.579 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.634794e-01 | 0.579 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.634794e-01 | 0.579 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.634794e-01 | 0.579 |
| R-HSA-162587 | HIV Life Cycle | 2.643159e-01 | 0.578 |
| R-HSA-877300 | Interferon gamma signaling | 2.697914e-01 | 0.569 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.709565e-01 | 0.567 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.709565e-01 | 0.567 |
| R-HSA-3214842 | HDMs demethylate histones | 2.709565e-01 | 0.567 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.709565e-01 | 0.567 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.709565e-01 | 0.567 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.725342e-01 | 0.565 |
| R-HSA-157118 | Signaling by NOTCH | 2.738328e-01 | 0.563 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.783581e-01 | 0.555 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.783581e-01 | 0.555 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.783581e-01 | 0.555 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.783581e-01 | 0.555 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.783581e-01 | 0.555 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 2.783581e-01 | 0.555 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.783581e-01 | 0.555 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.823158e-01 | 0.549 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.856850e-01 | 0.544 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.856850e-01 | 0.544 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.898218e-01 | 0.538 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.929380e-01 | 0.533 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.935717e-01 | 0.532 |
| R-HSA-4839726 | Chromatin organization | 2.941664e-01 | 0.531 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.973189e-01 | 0.527 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.001178e-01 | 0.523 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.001178e-01 | 0.523 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.001178e-01 | 0.523 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.001178e-01 | 0.523 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.001178e-01 | 0.523 |
| R-HSA-157579 | Telomere Maintenance | 3.010632e-01 | 0.521 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.072251e-01 | 0.513 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.072251e-01 | 0.513 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.072251e-01 | 0.513 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.072251e-01 | 0.513 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.072251e-01 | 0.513 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.072251e-01 | 0.513 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.072251e-01 | 0.513 |
| R-HSA-72766 | Translation | 3.102714e-01 | 0.508 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.122754e-01 | 0.505 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.142607e-01 | 0.503 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.142607e-01 | 0.503 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.142607e-01 | 0.503 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.142607e-01 | 0.503 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.142607e-01 | 0.503 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.197297e-01 | 0.495 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.212253e-01 | 0.493 |
| R-HSA-69190 | DNA strand elongation | 3.212253e-01 | 0.493 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.281195e-01 | 0.484 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.281195e-01 | 0.484 |
| R-HSA-9930044 | Nuclear RNA decay | 3.281195e-01 | 0.484 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.281195e-01 | 0.484 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.281195e-01 | 0.484 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.281195e-01 | 0.484 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.349442e-01 | 0.475 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.349442e-01 | 0.475 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.349442e-01 | 0.475 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.349442e-01 | 0.475 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.376613e-01 | 0.472 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.416999e-01 | 0.466 |
| R-HSA-203615 | eNOS activation | 3.416999e-01 | 0.466 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.416999e-01 | 0.466 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.416999e-01 | 0.466 |
| R-HSA-5673000 | RAF activation | 3.416999e-01 | 0.466 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.416999e-01 | 0.466 |
| R-HSA-211000 | Gene Silencing by RNA | 3.419694e-01 | 0.466 |
| R-HSA-73894 | DNA Repair | 3.454866e-01 | 0.462 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.483875e-01 | 0.458 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.483875e-01 | 0.458 |
| R-HSA-169911 | Regulation of Apoptosis | 3.483875e-01 | 0.458 |
| R-HSA-187687 | Signalling to ERKs | 3.483875e-01 | 0.458 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.483875e-01 | 0.458 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.493344e-01 | 0.457 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.550075e-01 | 0.450 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.550075e-01 | 0.450 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.550075e-01 | 0.450 |
| R-HSA-6798695 | Neutrophil degranulation | 3.605553e-01 | 0.443 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.610586e-01 | 0.442 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.615606e-01 | 0.442 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.615606e-01 | 0.442 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.615606e-01 | 0.442 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.615606e-01 | 0.442 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.629705e-01 | 0.440 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.638208e-01 | 0.439 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.680476e-01 | 0.434 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.680476e-01 | 0.434 |
| R-HSA-199991 | Membrane Trafficking | 3.728862e-01 | 0.428 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.744691e-01 | 0.427 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.744691e-01 | 0.427 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.744691e-01 | 0.427 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.744691e-01 | 0.427 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.744691e-01 | 0.427 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.744691e-01 | 0.427 |
| R-HSA-112316 | Neuronal System | 3.804954e-01 | 0.420 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.808257e-01 | 0.419 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.808257e-01 | 0.419 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.808257e-01 | 0.419 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.808257e-01 | 0.419 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.808257e-01 | 0.419 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.808257e-01 | 0.419 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.808257e-01 | 0.419 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.871181e-01 | 0.412 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.871181e-01 | 0.412 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.871181e-01 | 0.412 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.871181e-01 | 0.412 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.871181e-01 | 0.412 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.871181e-01 | 0.412 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.871181e-01 | 0.412 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.933470e-01 | 0.405 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.933470e-01 | 0.405 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.933470e-01 | 0.405 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.995129e-01 | 0.398 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.995129e-01 | 0.398 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.000190e-01 | 0.398 |
| R-HSA-73886 | Chromosome Maintenance | 4.000190e-01 | 0.398 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.071158e-01 | 0.390 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.071158e-01 | 0.390 |
| R-HSA-190828 | Gap junction trafficking | 4.116585e-01 | 0.385 |
| R-HSA-373752 | Netrin-1 signaling | 4.116585e-01 | 0.385 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.116585e-01 | 0.385 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.116585e-01 | 0.385 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.176394e-01 | 0.379 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.176394e-01 | 0.379 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.176394e-01 | 0.379 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.176394e-01 | 0.379 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.212302e-01 | 0.375 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.235599e-01 | 0.373 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.235599e-01 | 0.373 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.235599e-01 | 0.373 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.235599e-01 | 0.373 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.235599e-01 | 0.373 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.235599e-01 | 0.373 |
| R-HSA-437239 | Recycling pathway of L1 | 4.294205e-01 | 0.367 |
| R-HSA-1474165 | Reproduction | 4.385350e-01 | 0.358 |
| R-HSA-73893 | DNA Damage Bypass | 4.409648e-01 | 0.356 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.409648e-01 | 0.356 |
| R-HSA-9766229 | Degradation of CDH1 | 4.409648e-01 | 0.356 |
| R-HSA-9843745 | Adipogenesis | 4.419710e-01 | 0.355 |
| R-HSA-912446 | Meiotic recombination | 4.522768e-01 | 0.345 |
| R-HSA-72187 | mRNA 3'-end processing | 4.578473e-01 | 0.339 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.578473e-01 | 0.339 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.578473e-01 | 0.339 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.578473e-01 | 0.339 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.578473e-01 | 0.339 |
| R-HSA-162906 | HIV Infection | 4.611891e-01 | 0.336 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.630580e-01 | 0.334 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.630580e-01 | 0.334 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.633614e-01 | 0.334 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.633614e-01 | 0.334 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.633614e-01 | 0.334 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.633614e-01 | 0.334 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.656946e-01 | 0.332 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.723640e-01 | 0.326 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.742229e-01 | 0.324 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.742229e-01 | 0.324 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.742229e-01 | 0.324 |
| R-HSA-9664407 | Parasite infection | 4.756801e-01 | 0.323 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.756801e-01 | 0.323 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.756801e-01 | 0.323 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.795715e-01 | 0.319 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.795715e-01 | 0.319 |
| R-HSA-75893 | TNF signaling | 4.795715e-01 | 0.319 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.795715e-01 | 0.319 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.848659e-01 | 0.314 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.848659e-01 | 0.314 |
| R-HSA-8939211 | ESR-mediated signaling | 4.871714e-01 | 0.312 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.901069e-01 | 0.310 |
| R-HSA-180786 | Extension of Telomeres | 4.952948e-01 | 0.305 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.004303e-01 | 0.301 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.049503e-01 | 0.297 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.055138e-01 | 0.296 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.055138e-01 | 0.296 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.055138e-01 | 0.296 |
| R-HSA-1268020 | Mitochondrial protein import | 5.105459e-01 | 0.292 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.105459e-01 | 0.292 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.105459e-01 | 0.292 |
| R-HSA-9707616 | Heme signaling | 5.105459e-01 | 0.292 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 5.113111e-01 | 0.291 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.155271e-01 | 0.288 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.176185e-01 | 0.286 |
| R-HSA-421270 | Cell-cell junction organization | 5.225082e-01 | 0.282 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.238722e-01 | 0.281 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.253389e-01 | 0.280 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.362163e-01 | 0.271 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.536048e-01 | 0.257 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.536048e-01 | 0.257 |
| R-HSA-8978934 | Metabolism of cofactors | 5.536048e-01 | 0.257 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.536048e-01 | 0.257 |
| R-HSA-416476 | G alpha (q) signalling events | 5.541139e-01 | 0.256 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.543200e-01 | 0.256 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.581503e-01 | 0.253 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.581503e-01 | 0.253 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.581503e-01 | 0.253 |
| R-HSA-4086398 | Ca2+ pathway | 5.626499e-01 | 0.250 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.671039e-01 | 0.246 |
| R-HSA-168256 | Immune System | 5.686829e-01 | 0.245 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.715128e-01 | 0.243 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.715128e-01 | 0.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.775720e-01 | 0.238 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.801971e-01 | 0.236 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.833766e-01 | 0.234 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.833766e-01 | 0.234 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.833766e-01 | 0.234 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.844735e-01 | 0.233 |
| R-HSA-446728 | Cell junction organization | 5.867385e-01 | 0.232 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 5.887065e-01 | 0.230 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.928967e-01 | 0.227 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.935304e-01 | 0.227 |
| R-HSA-9658195 | Leishmania infection | 5.935304e-01 | 0.227 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.970445e-01 | 0.224 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.011502e-01 | 0.221 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.052144e-01 | 0.218 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.092374e-01 | 0.215 |
| R-HSA-1500620 | Meiosis | 6.132197e-01 | 0.212 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.132197e-01 | 0.212 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.171616e-01 | 0.210 |
| R-HSA-70268 | Pyruvate metabolism | 6.249260e-01 | 0.204 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.287494e-01 | 0.202 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.362802e-01 | 0.196 |
| R-HSA-73884 | Base Excision Repair | 6.362802e-01 | 0.196 |
| R-HSA-202424 | Downstream TCR signaling | 6.362802e-01 | 0.196 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.398089e-01 | 0.194 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.399885e-01 | 0.194 |
| R-HSA-9609690 | HCMV Early Events | 6.448602e-01 | 0.191 |
| R-HSA-449147 | Signaling by Interleukins | 6.469821e-01 | 0.189 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.472927e-01 | 0.189 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.544496e-01 | 0.184 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.632209e-01 | 0.178 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.649151e-01 | 0.177 |
| R-HSA-72172 | mRNA Splicing | 6.669045e-01 | 0.176 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.717165e-01 | 0.173 |
| R-HSA-422356 | Regulation of insulin secretion | 6.717165e-01 | 0.173 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.750656e-01 | 0.171 |
| R-HSA-70171 | Glycolysis | 6.783807e-01 | 0.169 |
| R-HSA-8957322 | Metabolism of steroids | 6.827871e-01 | 0.166 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.913084e-01 | 0.160 |
| R-HSA-68882 | Mitotic Anaphase | 6.945755e-01 | 0.158 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.967942e-01 | 0.157 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.975772e-01 | 0.156 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.975772e-01 | 0.156 |
| R-HSA-418346 | Platelet homeostasis | 7.006640e-01 | 0.154 |
| R-HSA-69239 | Synthesis of DNA | 7.037194e-01 | 0.153 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.037194e-01 | 0.153 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.037194e-01 | 0.153 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.067439e-01 | 0.151 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.067439e-01 | 0.151 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.097377e-01 | 0.149 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.127011e-01 | 0.147 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.127011e-01 | 0.147 |
| R-HSA-202403 | TCR signaling | 7.127011e-01 | 0.147 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.214121e-01 | 0.142 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.242570e-01 | 0.140 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.270730e-01 | 0.138 |
| R-HSA-168249 | Innate Immune System | 7.289552e-01 | 0.137 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.326196e-01 | 0.135 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.326196e-01 | 0.135 |
| R-HSA-70326 | Glucose metabolism | 7.380542e-01 | 0.132 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.380542e-01 | 0.132 |
| R-HSA-68875 | Mitotic Prophase | 7.460009e-01 | 0.127 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.504880e-01 | 0.125 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 7.537079e-01 | 0.123 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.562249e-01 | 0.121 |
| R-HSA-69206 | G1/S Transition | 7.611825e-01 | 0.119 |
| R-HSA-9609646 | HCMV Infection | 7.628310e-01 | 0.118 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.636235e-01 | 0.117 |
| R-HSA-114608 | Platelet degranulation | 7.660398e-01 | 0.116 |
| R-HSA-5688426 | Deubiquitination | 7.716781e-01 | 0.113 |
| R-HSA-9717189 | Sensory perception of taste | 7.777578e-01 | 0.109 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.800305e-01 | 0.108 |
| R-HSA-9909396 | Circadian clock | 7.800305e-01 | 0.108 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.800305e-01 | 0.108 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.822800e-01 | 0.107 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.852388e-01 | 0.105 |
| R-HSA-163685 | Integration of energy metabolism | 7.910518e-01 | 0.102 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.910518e-01 | 0.102 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.910518e-01 | 0.102 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.933529e-01 | 0.101 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.055654e-01 | 0.094 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.075553e-01 | 0.093 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.134043e-01 | 0.090 |
| R-HSA-418594 | G alpha (i) signalling events | 8.137688e-01 | 0.089 |
| R-HSA-69242 | S Phase | 8.172052e-01 | 0.088 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.227626e-01 | 0.085 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.245776e-01 | 0.084 |
| R-HSA-9609507 | Protein localization | 8.263740e-01 | 0.083 |
| R-HSA-69306 | DNA Replication | 8.263740e-01 | 0.083 |
| R-HSA-9610379 | HCMV Late Events | 8.333787e-01 | 0.079 |
| R-HSA-195721 | Signaling by WNT | 8.365971e-01 | 0.077 |
| R-HSA-5619102 | SLC transporter disorders | 8.496858e-01 | 0.071 |
| R-HSA-72306 | tRNA processing | 8.557553e-01 | 0.068 |
| R-HSA-1280218 | Adaptive Immune System | 8.568801e-01 | 0.067 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.572342e-01 | 0.067 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.586980e-01 | 0.066 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.601469e-01 | 0.065 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.601469e-01 | 0.065 |
| R-HSA-611105 | Respiratory electron transport | 8.671730e-01 | 0.062 |
| R-HSA-2559583 | Cellular Senescence | 8.698842e-01 | 0.061 |
| R-HSA-74160 | Gene expression (Transcription) | 8.732574e-01 | 0.059 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.738481e-01 | 0.059 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.844422e-01 | 0.053 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.896837e-01 | 0.051 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.934988e-01 | 0.049 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.941463e-01 | 0.049 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.941463e-01 | 0.049 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.973751e-01 | 0.047 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.973751e-01 | 0.047 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.083986e-01 | 0.042 |
| R-HSA-388396 | GPCR downstream signalling | 9.113283e-01 | 0.040 |
| R-HSA-418990 | Adherens junctions interactions | 9.130122e-01 | 0.040 |
| R-HSA-392499 | Metabolism of proteins | 9.175984e-01 | 0.037 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.285325e-01 | 0.032 |
| R-HSA-597592 | Post-translational protein modification | 9.302248e-01 | 0.031 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.355613e-01 | 0.029 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.412975e-01 | 0.026 |
| R-HSA-382551 | Transport of small molecules | 9.458075e-01 | 0.024 |
| R-HSA-372790 | Signaling by GPCR | 9.477389e-01 | 0.023 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.551713e-01 | 0.020 |
| R-HSA-212436 | Generic Transcription Pathway | 9.643075e-01 | 0.016 |
| R-HSA-109582 | Hemostasis | 9.662198e-01 | 0.015 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.680440e-01 | 0.014 |
| R-HSA-1474244 | Extracellular matrix organization | 9.730635e-01 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 9.746575e-01 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.809027e-01 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.845014e-01 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.855945e-01 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.927073e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.967052e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999594e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.871 | 0.189 | 2 | 0.869 |
CLK3 |
0.858 | 0.194 | 1 | 0.836 |
IKKB |
0.854 | 0.065 | -2 | 0.794 |
NDR2 |
0.854 | 0.088 | -3 | 0.803 |
TBK1 |
0.852 | 0.081 | 1 | 0.799 |
RAF1 |
0.852 | 0.051 | 1 | 0.879 |
PIM3 |
0.851 | 0.070 | -3 | 0.801 |
CDC7 |
0.850 | -0.015 | 1 | 0.830 |
ULK2 |
0.850 | 0.002 | 2 | 0.785 |
RSK2 |
0.850 | 0.128 | -3 | 0.746 |
IKKE |
0.850 | 0.073 | 1 | 0.804 |
DSTYK |
0.850 | 0.058 | 2 | 0.861 |
GCN2 |
0.849 | -0.067 | 2 | 0.803 |
NLK |
0.849 | 0.053 | 1 | 0.825 |
CAMK1B |
0.849 | 0.061 | -3 | 0.828 |
NDR1 |
0.848 | 0.089 | -3 | 0.798 |
WNK1 |
0.848 | 0.101 | -2 | 0.881 |
PRPK |
0.848 | -0.114 | -1 | 0.805 |
MOS |
0.848 | 0.027 | 1 | 0.856 |
PKCD |
0.847 | 0.162 | 2 | 0.793 |
NEK7 |
0.847 | 0.032 | -3 | 0.794 |
CAMK2G |
0.847 | 0.038 | 2 | 0.812 |
IKKA |
0.846 | 0.147 | -2 | 0.776 |
ATR |
0.845 | 0.044 | 1 | 0.859 |
AMPKA1 |
0.845 | 0.119 | -3 | 0.808 |
MARK4 |
0.845 | 0.079 | 4 | 0.903 |
SKMLCK |
0.845 | 0.095 | -2 | 0.880 |
MST4 |
0.844 | 0.076 | 2 | 0.828 |
CDKL1 |
0.844 | 0.036 | -3 | 0.769 |
PKN3 |
0.844 | 0.036 | -3 | 0.789 |
MTOR |
0.844 | -0.084 | 1 | 0.786 |
GRK6 |
0.844 | 0.132 | 1 | 0.847 |
NEK6 |
0.844 | 0.033 | -2 | 0.894 |
GRK1 |
0.843 | 0.114 | -2 | 0.784 |
P90RSK |
0.843 | 0.069 | -3 | 0.749 |
RIPK3 |
0.843 | -0.009 | 3 | 0.729 |
NUAK2 |
0.843 | 0.052 | -3 | 0.805 |
LATS2 |
0.843 | 0.081 | -5 | 0.748 |
TSSK1 |
0.842 | 0.135 | -3 | 0.827 |
PKACG |
0.842 | 0.124 | -2 | 0.793 |
CAMLCK |
0.842 | 0.093 | -2 | 0.890 |
MLK1 |
0.842 | 0.004 | 2 | 0.819 |
PDHK4 |
0.842 | -0.216 | 1 | 0.872 |
BMPR2 |
0.842 | -0.098 | -2 | 0.897 |
PDHK1 |
0.842 | -0.070 | 1 | 0.892 |
TSSK2 |
0.841 | 0.106 | -5 | 0.792 |
NIK |
0.841 | 0.042 | -3 | 0.841 |
TGFBR2 |
0.841 | 0.012 | -2 | 0.814 |
WNK3 |
0.841 | -0.014 | 1 | 0.850 |
PIM1 |
0.840 | 0.094 | -3 | 0.749 |
ULK1 |
0.839 | -0.060 | -3 | 0.784 |
SRPK1 |
0.839 | 0.057 | -3 | 0.720 |
RSK3 |
0.839 | 0.061 | -3 | 0.741 |
HUNK |
0.839 | -0.049 | 2 | 0.814 |
AMPKA2 |
0.838 | 0.094 | -3 | 0.781 |
GRK5 |
0.838 | -0.056 | -3 | 0.815 |
PKN2 |
0.838 | 0.035 | -3 | 0.791 |
P70S6KB |
0.838 | 0.073 | -3 | 0.763 |
AURC |
0.838 | 0.146 | -2 | 0.718 |
DAPK2 |
0.838 | 0.059 | -3 | 0.825 |
ERK5 |
0.838 | -0.018 | 1 | 0.760 |
PRKD2 |
0.838 | 0.066 | -3 | 0.735 |
RSK4 |
0.837 | 0.130 | -3 | 0.723 |
CDKL5 |
0.836 | 0.019 | -3 | 0.757 |
NIM1 |
0.836 | 0.002 | 3 | 0.755 |
SRPK2 |
0.836 | 0.065 | -3 | 0.649 |
CHAK2 |
0.835 | -0.015 | -1 | 0.832 |
MNK2 |
0.835 | 0.109 | -2 | 0.839 |
PAK1 |
0.835 | 0.099 | -2 | 0.816 |
FAM20C |
0.835 | 0.044 | 2 | 0.543 |
PLK1 |
0.834 | 0.091 | -2 | 0.857 |
MAPKAPK3 |
0.834 | 0.021 | -3 | 0.725 |
AURB |
0.834 | 0.151 | -2 | 0.720 |
HIPK4 |
0.834 | 0.012 | 1 | 0.795 |
LATS1 |
0.834 | 0.113 | -3 | 0.821 |
NEK9 |
0.834 | -0.044 | 2 | 0.830 |
ICK |
0.833 | 0.032 | -3 | 0.797 |
IRE1 |
0.833 | -0.026 | 1 | 0.826 |
ANKRD3 |
0.833 | -0.011 | 1 | 0.881 |
GRK4 |
0.833 | -0.024 | -2 | 0.829 |
PRKD1 |
0.832 | -0.024 | -3 | 0.772 |
PKACB |
0.832 | 0.149 | -2 | 0.736 |
ATM |
0.832 | 0.047 | 1 | 0.803 |
CLK4 |
0.832 | 0.116 | -3 | 0.742 |
GRK7 |
0.832 | 0.167 | 1 | 0.752 |
QSK |
0.832 | 0.076 | 4 | 0.881 |
MSK2 |
0.832 | 0.053 | -3 | 0.696 |
PKR |
0.832 | 0.095 | 1 | 0.880 |
PAK6 |
0.832 | 0.141 | -2 | 0.768 |
MAPKAPK2 |
0.831 | 0.048 | -3 | 0.697 |
CAMK2D |
0.831 | -0.013 | -3 | 0.782 |
KIS |
0.831 | -0.011 | 1 | 0.683 |
DLK |
0.831 | -0.065 | 1 | 0.860 |
TTBK2 |
0.831 | -0.084 | 2 | 0.704 |
PAK3 |
0.830 | 0.052 | -2 | 0.818 |
PRKX |
0.830 | 0.171 | -3 | 0.659 |
CLK1 |
0.830 | 0.117 | -3 | 0.722 |
NUAK1 |
0.830 | 0.029 | -3 | 0.760 |
CAMK2B |
0.830 | 0.074 | 2 | 0.771 |
PKCB |
0.830 | 0.066 | 2 | 0.749 |
PKCG |
0.830 | 0.057 | 2 | 0.749 |
SIK |
0.830 | 0.058 | -3 | 0.727 |
QIK |
0.830 | 0.012 | -3 | 0.781 |
BMPR1B |
0.830 | 0.105 | 1 | 0.773 |
MARK3 |
0.830 | 0.088 | 4 | 0.859 |
MARK2 |
0.829 | 0.090 | 4 | 0.828 |
MSK1 |
0.829 | 0.103 | -3 | 0.703 |
BCKDK |
0.829 | -0.145 | -1 | 0.733 |
IRE2 |
0.829 | 0.010 | 2 | 0.766 |
MLK3 |
0.829 | 0.008 | 2 | 0.749 |
PKG2 |
0.829 | 0.121 | -2 | 0.733 |
MNK1 |
0.829 | 0.098 | -2 | 0.843 |
SGK3 |
0.828 | 0.117 | -3 | 0.715 |
ALK4 |
0.828 | 0.034 | -2 | 0.828 |
MELK |
0.828 | 0.026 | -3 | 0.761 |
MYLK4 |
0.828 | 0.079 | -2 | 0.817 |
RIPK1 |
0.828 | -0.134 | 1 | 0.837 |
PKCA |
0.827 | 0.063 | 2 | 0.735 |
CAMK4 |
0.827 | -0.026 | -3 | 0.778 |
PLK3 |
0.827 | 0.083 | 2 | 0.758 |
TGFBR1 |
0.826 | 0.061 | -2 | 0.796 |
PAK2 |
0.826 | 0.069 | -2 | 0.806 |
SRPK3 |
0.826 | 0.022 | -3 | 0.694 |
PKCH |
0.826 | 0.048 | 2 | 0.741 |
TLK2 |
0.826 | 0.055 | 1 | 0.853 |
DYRK2 |
0.825 | 0.038 | 1 | 0.682 |
MLK2 |
0.825 | -0.106 | 2 | 0.805 |
MLK4 |
0.825 | 0.013 | 2 | 0.734 |
PRKD3 |
0.825 | 0.029 | -3 | 0.709 |
CDK8 |
0.824 | -0.021 | 1 | 0.651 |
MASTL |
0.824 | -0.274 | -2 | 0.835 |
PLK4 |
0.824 | 0.001 | 2 | 0.659 |
ACVR2A |
0.824 | 0.063 | -2 | 0.805 |
CAMK2A |
0.824 | 0.049 | 2 | 0.796 |
BRSK1 |
0.824 | 0.015 | -3 | 0.749 |
NEK2 |
0.824 | -0.008 | 2 | 0.802 |
MEK1 |
0.824 | -0.057 | 2 | 0.829 |
AURA |
0.824 | 0.114 | -2 | 0.699 |
PKCZ |
0.824 | 0.026 | 2 | 0.777 |
MARK1 |
0.823 | 0.054 | 4 | 0.875 |
AKT2 |
0.822 | 0.084 | -3 | 0.663 |
YSK4 |
0.822 | -0.037 | 1 | 0.819 |
SSTK |
0.822 | 0.107 | 4 | 0.875 |
ACVR2B |
0.822 | 0.055 | -2 | 0.816 |
VRK2 |
0.821 | -0.111 | 1 | 0.889 |
BRSK2 |
0.821 | -0.012 | -3 | 0.763 |
DNAPK |
0.821 | 0.068 | 1 | 0.756 |
WNK4 |
0.820 | 0.027 | -2 | 0.872 |
ALK2 |
0.820 | 0.053 | -2 | 0.810 |
CAMK1G |
0.820 | 0.019 | -3 | 0.725 |
CHAK1 |
0.820 | -0.069 | 2 | 0.736 |
BRAF |
0.820 | 0.043 | -4 | 0.753 |
JNK2 |
0.820 | 0.047 | 1 | 0.594 |
AKT1 |
0.819 | 0.126 | -3 | 0.674 |
CLK2 |
0.819 | 0.113 | -3 | 0.728 |
JNK3 |
0.819 | 0.035 | 1 | 0.625 |
PKACA |
0.819 | 0.126 | -2 | 0.688 |
PHKG1 |
0.818 | -0.055 | -3 | 0.779 |
CHK1 |
0.818 | -0.014 | -3 | 0.796 |
SMG1 |
0.818 | -0.024 | 1 | 0.816 |
BMPR1A |
0.817 | 0.103 | 1 | 0.760 |
PIM2 |
0.817 | 0.050 | -3 | 0.716 |
HIPK1 |
0.817 | 0.059 | 1 | 0.700 |
MEKK3 |
0.817 | -0.062 | 1 | 0.838 |
IRAK4 |
0.816 | -0.013 | 1 | 0.837 |
MEKK1 |
0.816 | -0.006 | 1 | 0.870 |
SMMLCK |
0.816 | 0.068 | -3 | 0.776 |
CDK5 |
0.816 | 0.005 | 1 | 0.663 |
MEKK2 |
0.816 | 0.012 | 2 | 0.802 |
DCAMKL1 |
0.816 | 0.020 | -3 | 0.754 |
CDK19 |
0.815 | -0.036 | 1 | 0.608 |
CDK7 |
0.815 | -0.051 | 1 | 0.649 |
ERK2 |
0.815 | -0.005 | 1 | 0.637 |
CDK1 |
0.815 | 0.010 | 1 | 0.601 |
PERK |
0.815 | -0.067 | -2 | 0.855 |
PKCT |
0.815 | 0.047 | 2 | 0.745 |
P38A |
0.815 | -0.001 | 1 | 0.667 |
PHKG2 |
0.814 | 0.010 | -3 | 0.767 |
DRAK1 |
0.814 | -0.066 | 1 | 0.728 |
ZAK |
0.814 | -0.034 | 1 | 0.841 |
GRK2 |
0.814 | -0.040 | -2 | 0.730 |
CDK2 |
0.814 | -0.006 | 1 | 0.686 |
PAK5 |
0.814 | 0.102 | -2 | 0.695 |
SNRK |
0.813 | -0.132 | 2 | 0.694 |
HIPK2 |
0.813 | 0.041 | 1 | 0.588 |
MEK5 |
0.812 | -0.138 | 2 | 0.814 |
ERK1 |
0.812 | -0.000 | 1 | 0.584 |
DYRK1A |
0.812 | 0.019 | 1 | 0.724 |
PAK4 |
0.812 | 0.107 | -2 | 0.703 |
TLK1 |
0.812 | -0.048 | -2 | 0.837 |
DYRK3 |
0.811 | 0.079 | 1 | 0.711 |
P38G |
0.811 | 0.016 | 1 | 0.512 |
NEK5 |
0.811 | -0.039 | 1 | 0.850 |
MST3 |
0.811 | 0.011 | 2 | 0.820 |
P38B |
0.811 | 0.008 | 1 | 0.596 |
TAO3 |
0.810 | 0.017 | 1 | 0.831 |
CDK18 |
0.810 | -0.017 | 1 | 0.569 |
HRI |
0.810 | -0.145 | -2 | 0.867 |
P70S6K |
0.810 | 0.012 | -3 | 0.670 |
PRP4 |
0.809 | -0.005 | -3 | 0.737 |
CK2A2 |
0.809 | 0.200 | 1 | 0.674 |
DAPK3 |
0.809 | 0.106 | -3 | 0.765 |
MAPKAPK5 |
0.809 | -0.109 | -3 | 0.659 |
TTBK1 |
0.809 | -0.093 | 2 | 0.629 |
CDK13 |
0.809 | -0.060 | 1 | 0.619 |
PINK1 |
0.809 | -0.119 | 1 | 0.831 |
CAMK1D |
0.808 | 0.052 | -3 | 0.646 |
MRCKA |
0.808 | 0.145 | -3 | 0.718 |
MRCKB |
0.808 | 0.142 | -3 | 0.703 |
PKCI |
0.808 | 0.029 | 2 | 0.752 |
DCAMKL2 |
0.808 | -0.035 | -3 | 0.780 |
DYRK1B |
0.807 | 0.034 | 1 | 0.629 |
ROCK2 |
0.807 | 0.165 | -3 | 0.746 |
NEK8 |
0.807 | -0.045 | 2 | 0.815 |
CDK17 |
0.807 | -0.021 | 1 | 0.518 |
PKCE |
0.806 | 0.071 | 2 | 0.732 |
DYRK4 |
0.806 | 0.027 | 1 | 0.599 |
CDK3 |
0.806 | 0.039 | 1 | 0.533 |
PLK2 |
0.805 | 0.122 | -3 | 0.851 |
HIPK3 |
0.805 | 0.005 | 1 | 0.700 |
CK1G1 |
0.805 | -0.060 | -3 | 0.513 |
PASK |
0.804 | -0.031 | -3 | 0.810 |
CK1E |
0.804 | -0.085 | -3 | 0.508 |
GAK |
0.804 | -0.001 | 1 | 0.810 |
AKT3 |
0.804 | 0.095 | -3 | 0.598 |
SGK1 |
0.804 | 0.096 | -3 | 0.583 |
CDK12 |
0.803 | -0.052 | 1 | 0.594 |
MST2 |
0.803 | 0.033 | 1 | 0.857 |
DAPK1 |
0.803 | 0.082 | -3 | 0.745 |
GRK3 |
0.802 | -0.031 | -2 | 0.681 |
TAO2 |
0.802 | -0.037 | 2 | 0.836 |
CAMKK1 |
0.802 | -0.080 | -2 | 0.807 |
IRAK1 |
0.802 | -0.167 | -1 | 0.736 |
CDK14 |
0.802 | -0.016 | 1 | 0.620 |
GSK3A |
0.801 | 0.009 | 4 | 0.451 |
CDK9 |
0.800 | -0.080 | 1 | 0.625 |
NEK4 |
0.800 | -0.035 | 1 | 0.850 |
MPSK1 |
0.800 | -0.061 | 1 | 0.776 |
CAMK1A |
0.799 | 0.048 | -3 | 0.631 |
CK2A1 |
0.799 | 0.165 | 1 | 0.653 |
CAMKK2 |
0.799 | -0.062 | -2 | 0.804 |
PDK1 |
0.799 | -0.074 | 1 | 0.800 |
P38D |
0.799 | 0.013 | 1 | 0.534 |
DMPK1 |
0.799 | 0.159 | -3 | 0.734 |
EEF2K |
0.799 | -0.024 | 3 | 0.791 |
CDK16 |
0.798 | -0.003 | 1 | 0.534 |
NEK11 |
0.798 | -0.147 | 1 | 0.834 |
PKN1 |
0.797 | -0.002 | -3 | 0.682 |
GSK3B |
0.797 | -0.044 | 4 | 0.441 |
JNK1 |
0.797 | 0.007 | 1 | 0.571 |
TAK1 |
0.797 | -0.008 | 1 | 0.862 |
TNIK |
0.796 | 0.021 | 3 | 0.791 |
GCK |
0.796 | -0.017 | 1 | 0.843 |
CK1A2 |
0.796 | -0.069 | -3 | 0.450 |
LOK |
0.796 | 0.009 | -2 | 0.814 |
MINK |
0.796 | -0.005 | 1 | 0.853 |
CDK10 |
0.795 | -0.003 | 1 | 0.602 |
HGK |
0.795 | -0.024 | 3 | 0.785 |
CHK2 |
0.795 | 0.013 | -3 | 0.610 |
MST1 |
0.795 | 0.010 | 1 | 0.850 |
VRK1 |
0.795 | -0.068 | 2 | 0.848 |
LKB1 |
0.795 | -0.105 | -3 | 0.767 |
ROCK1 |
0.794 | 0.141 | -3 | 0.716 |
LRRK2 |
0.794 | -0.085 | 2 | 0.834 |
CK1D |
0.793 | -0.089 | -3 | 0.450 |
MAP3K15 |
0.793 | -0.080 | 1 | 0.810 |
NEK1 |
0.793 | -0.041 | 1 | 0.837 |
ERK7 |
0.793 | -0.006 | 2 | 0.556 |
PKG1 |
0.792 | 0.075 | -2 | 0.654 |
MAK |
0.791 | 0.055 | -2 | 0.723 |
SLK |
0.791 | -0.028 | -2 | 0.750 |
STK33 |
0.791 | -0.115 | 2 | 0.612 |
MEKK6 |
0.790 | -0.130 | 1 | 0.828 |
MOK |
0.790 | 0.064 | 1 | 0.698 |
HPK1 |
0.790 | -0.030 | 1 | 0.838 |
TTK |
0.790 | 0.083 | -2 | 0.848 |
KHS2 |
0.789 | 0.036 | 1 | 0.853 |
KHS1 |
0.788 | 0.013 | 1 | 0.845 |
RIPK2 |
0.788 | -0.166 | 1 | 0.801 |
MEK2 |
0.788 | -0.136 | 2 | 0.804 |
BUB1 |
0.788 | 0.023 | -5 | 0.732 |
PDHK3_TYR |
0.787 | 0.178 | 4 | 0.901 |
YSK1 |
0.787 | -0.042 | 2 | 0.798 |
CDK4 |
0.787 | -0.023 | 1 | 0.584 |
CDK6 |
0.786 | -0.032 | 1 | 0.594 |
SBK |
0.786 | 0.031 | -3 | 0.551 |
CRIK |
0.784 | 0.073 | -3 | 0.672 |
HASPIN |
0.784 | 0.050 | -1 | 0.715 |
OSR1 |
0.780 | -0.012 | 2 | 0.787 |
PBK |
0.777 | -0.078 | 1 | 0.726 |
PDHK4_TYR |
0.777 | 0.058 | 2 | 0.844 |
NEK3 |
0.776 | -0.137 | 1 | 0.802 |
MAP2K7_TYR |
0.775 | -0.095 | 2 | 0.839 |
TESK1_TYR |
0.775 | -0.095 | 3 | 0.837 |
BMPR2_TYR |
0.774 | 0.001 | -1 | 0.818 |
MYO3B |
0.773 | -0.031 | 2 | 0.803 |
ALPHAK3 |
0.773 | -0.022 | -1 | 0.719 |
MYO3A |
0.773 | -0.034 | 1 | 0.859 |
MAP2K6_TYR |
0.772 | -0.066 | -1 | 0.828 |
PKMYT1_TYR |
0.772 | -0.121 | 3 | 0.813 |
PINK1_TYR |
0.771 | -0.115 | 1 | 0.836 |
MAP2K4_TYR |
0.771 | -0.156 | -1 | 0.820 |
TAO1 |
0.771 | -0.059 | 1 | 0.783 |
PDHK1_TYR |
0.769 | -0.077 | -1 | 0.829 |
LIMK2_TYR |
0.769 | -0.031 | -3 | 0.840 |
ASK1 |
0.769 | -0.125 | 1 | 0.799 |
BIKE |
0.768 | -0.053 | 1 | 0.670 |
RET |
0.768 | -0.038 | 1 | 0.837 |
YANK3 |
0.768 | -0.083 | 2 | 0.389 |
TYK2 |
0.767 | -0.073 | 1 | 0.841 |
EPHA6 |
0.766 | -0.017 | -1 | 0.788 |
LIMK1_TYR |
0.765 | -0.151 | 2 | 0.834 |
JAK2 |
0.764 | -0.071 | 1 | 0.838 |
STLK3 |
0.763 | -0.080 | 1 | 0.820 |
MST1R |
0.763 | -0.106 | 3 | 0.769 |
TYRO3 |
0.763 | -0.100 | 3 | 0.759 |
ROS1 |
0.763 | -0.088 | 3 | 0.744 |
CSF1R |
0.762 | -0.056 | 3 | 0.747 |
YES1 |
0.761 | -0.036 | -1 | 0.790 |
DDR1 |
0.761 | -0.126 | 4 | 0.846 |
EPHB4 |
0.760 | -0.070 | -1 | 0.759 |
TXK |
0.760 | 0.035 | 1 | 0.810 |
TNNI3K_TYR |
0.758 | 0.019 | 1 | 0.877 |
CK1A |
0.758 | -0.113 | -3 | 0.367 |
SRMS |
0.757 | -0.045 | 1 | 0.846 |
PDGFRB |
0.757 | -0.069 | 3 | 0.766 |
ABL2 |
0.757 | -0.078 | -1 | 0.752 |
FER |
0.757 | -0.124 | 1 | 0.851 |
INSRR |
0.756 | -0.091 | 3 | 0.725 |
TNK2 |
0.756 | -0.072 | 3 | 0.723 |
TNK1 |
0.756 | -0.045 | 3 | 0.734 |
EPHB1 |
0.755 | -0.055 | 1 | 0.855 |
ITK |
0.755 | -0.047 | -1 | 0.754 |
KDR |
0.755 | -0.074 | 3 | 0.726 |
FLT3 |
0.755 | -0.086 | 3 | 0.743 |
JAK3 |
0.755 | -0.124 | 1 | 0.796 |
FGR |
0.754 | -0.159 | 1 | 0.827 |
HCK |
0.753 | -0.108 | -1 | 0.779 |
EPHA4 |
0.752 | -0.077 | 2 | 0.745 |
FGFR2 |
0.752 | -0.122 | 3 | 0.762 |
LCK |
0.752 | -0.043 | -1 | 0.779 |
BLK |
0.752 | -0.011 | -1 | 0.782 |
ABL1 |
0.751 | -0.121 | -1 | 0.746 |
KIT |
0.751 | -0.118 | 3 | 0.745 |
JAK1 |
0.751 | -0.059 | 1 | 0.791 |
EPHB2 |
0.751 | -0.055 | -1 | 0.736 |
NEK10_TYR |
0.751 | -0.097 | 1 | 0.697 |
TEC |
0.751 | -0.059 | -1 | 0.689 |
FGFR1 |
0.750 | -0.122 | 3 | 0.748 |
BTK |
0.750 | -0.123 | -1 | 0.718 |
AXL |
0.749 | -0.115 | 3 | 0.740 |
FYN |
0.749 | 0.004 | -1 | 0.755 |
LTK |
0.749 | -0.076 | 3 | 0.734 |
TEK |
0.749 | -0.141 | 3 | 0.705 |
ALK |
0.749 | -0.083 | 3 | 0.715 |
MERTK |
0.749 | -0.089 | 3 | 0.737 |
BMX |
0.749 | -0.063 | -1 | 0.672 |
AAK1 |
0.749 | -0.029 | 1 | 0.556 |
DDR2 |
0.749 | -0.004 | 3 | 0.730 |
EPHB3 |
0.748 | -0.128 | -1 | 0.736 |
PDGFRA |
0.747 | -0.178 | 3 | 0.765 |
CK1G3 |
0.747 | -0.079 | -3 | 0.322 |
MET |
0.746 | -0.116 | 3 | 0.740 |
WEE1_TYR |
0.746 | -0.116 | -1 | 0.686 |
FRK |
0.745 | -0.075 | -1 | 0.777 |
EPHA7 |
0.744 | -0.080 | 2 | 0.752 |
PTK6 |
0.743 | -0.160 | -1 | 0.666 |
FLT1 |
0.743 | -0.119 | -1 | 0.760 |
NTRK1 |
0.743 | -0.175 | -1 | 0.740 |
FGFR3 |
0.741 | -0.143 | 3 | 0.738 |
FLT4 |
0.741 | -0.155 | 3 | 0.724 |
EPHA1 |
0.741 | -0.120 | 3 | 0.714 |
LYN |
0.741 | -0.089 | 3 | 0.693 |
ERBB2 |
0.740 | -0.171 | 1 | 0.777 |
NTRK2 |
0.740 | -0.174 | 3 | 0.727 |
EPHA3 |
0.739 | -0.154 | 2 | 0.727 |
INSR |
0.738 | -0.169 | 3 | 0.699 |
PTK2B |
0.737 | -0.103 | -1 | 0.725 |
PTK2 |
0.735 | -0.011 | -1 | 0.746 |
EGFR |
0.735 | -0.075 | 1 | 0.684 |
SRC |
0.735 | -0.095 | -1 | 0.744 |
MATK |
0.735 | -0.138 | -1 | 0.664 |
EPHA5 |
0.735 | -0.097 | 2 | 0.734 |
CSK |
0.734 | -0.129 | 2 | 0.760 |
EPHA8 |
0.733 | -0.095 | -1 | 0.714 |
YANK2 |
0.733 | -0.118 | 2 | 0.405 |
NTRK3 |
0.731 | -0.183 | -1 | 0.680 |
FGFR4 |
0.730 | -0.107 | -1 | 0.688 |
SYK |
0.730 | -0.040 | -1 | 0.703 |
IGF1R |
0.725 | -0.148 | 3 | 0.650 |
EPHA2 |
0.725 | -0.092 | -1 | 0.689 |
ERBB4 |
0.720 | -0.095 | 1 | 0.700 |
CK1G2 |
0.719 | -0.115 | -3 | 0.422 |
MUSK |
0.717 | -0.200 | 1 | 0.661 |
FES |
0.711 | -0.170 | -1 | 0.637 |
ZAP70 |
0.699 | -0.132 | -1 | 0.644 |